Web Desc
New Insights into Healthspan and Diseases of Aging: From Molecular to Functional Senescence
Organizer(s): Sean M. Oldham, David A. Sinclair, Jan Vijg and Heidi Scrable
Date: January 31 - February 05, 2010
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Supported by The Directors' Fund
Summary of Meeting:
Aging can be defined as the gradual loss of the ability of the organism to maintain homeostasis. Our aim will be to focus on the molecular and cellular mechanisms by which tissue and organ function deteriorate and homeostasis fails rather than on longevity itself, which has been the theme of previous Keystone Symposia meetings on aging. Work from a variety of models is recognizing that organisms, especially humans, are complicated systems in which interventions that extend lifespan might not necessarily block the aging and loss of function in specific organs or tissues and vice versa. Continuing this approach will help us gain an understanding and appreciation of the complexity that underlies aging in humans. The aim of this meeting is to reveal the integration and communication between pathways and systems during functional aging and their relationship with longevity. This meeting will highlight important questions to address in future research. Most importantly, what are the common and disparate causes underlying the cellular and physiological mechanisms responsible for human senescent phenotypes?
Scholarship Deadline: September 24 2009
Discounted Abstract Deadline: September 24 2009
Abstract Deadline: October 30 2009
Discounted Registration Deadline: November 30 2009
We gratefully acknowledge additional support for this conference from:
The Ellison Medical Foundation
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Gerontological Society of America
We gratefully acknowledge the generous grant for this conference provided by:

National Institute on Aging (NIA)
Grant No. 1R13AG034755-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 31 | 3:00PM - 7:30PM
Registration
Room: Pre Function


Sunday, January 31 | 7:30PM - 8:30PM
Keynote Address
Room: Mountain/Lake

Speaker 1 of 1
Andrzej Bartke, Southern Illinois University School of Medicine, USA
Growth Hormone: Elixir of Youth or Dangerous Snake Oil?

Monday, February 01 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, February 01 | 8:00AM - 11:15AM
Aging Pathways I
Room: Mountain/Lake

Speaker 1 of 7
* Marc Tatar, Brown University, USA

Monday, February 01 | 8:00AM - 11:15AM
Aging Pathways I
Room: Mountain/Lake

Speaker 2 of 7
Cynthia Kenyon, Calico, USA
Insulin and Aging

Monday, February 01 | 8:00AM - 11:15AM
Aging Pathways I
Room: Mountain/Lake

Speaker 3 of 7
Leonard P. Guarente, Massachusetts Institute of Technology, USA
Sirtuins Aging and Disease

Monday, February 01 | 8:00AM - 11:15AM
Aging Pathways I
Room: Mountain/Lake

Speaker 4 of 7
Daniel E.L. Promislow, University of Washington, USA
Networks and the Evolution of Aging

Monday, February 01 | 8:00AM - 11:15AM
Aging Pathways I
Room: Mountain/Lake

Speaker 5 of 7
Anne Brunet, Stanford University, USA
The Plasticity of Aging Describing the Role of FoxO3 in Maintaining Neuronal Stem Cell Pool

Monday, February 01 | 8:00AM - 11:15AM
Aging Pathways I
Room: Mountain/Lake

Speaker 6 of 7
William B. Mair, Harvard School of Public Health, USA
Short Talk: AMPK and Calcineurin extend lifespan via the CREB Regulated Transcription Co-activator (CRTC-1)

Monday, February 01 | 8:00AM - 11:15AM
Aging Pathways I
Room: Mountain/Lake

Speaker 7 of 7
Maaike van den Berg, University of Bristol, UK
Short Talk: Regulation of FOXO4 through ROS Regulated Ral-JIP1-JNK Complex Assembly

Monday, February 01 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Monday, February 01 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, February 01 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Monday, February 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Monday, February 01 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Monday, February 01 | 5:00PM - 7:00PM
Aging Pathways II
Room: Mountain/Lake

Speaker 1 of 5
* Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA

Monday, February 01 | 5:00PM - 7:00PM
Aging Pathways II
Room: Mountain/Lake

Speaker 2 of 5
Jennifer Cermak, Sirtris, a GSK Company, USA
Targeting Sirtuins: Drug Development for Diseases of Aging

Monday, February 01 | 5:00PM - 7:00PM
Aging Pathways II
Room: Mountain/Lake

Speaker 3 of 5
Robert S. Garofalo, USA
Insulin Resistane: Insights from high resolution transcriptional profiling

Monday, February 01 | 5:00PM - 7:00PM
Aging Pathways II
Room: Mountain/Lake

Speaker 4 of 5
Sean M. Oldham, Takeda Pharmaceuticals International Co., USA
Role of Nutrient Sensing TOR Pathway in Obesity and Aging

Monday, February 01 | 5:00PM - 7:00PM
Aging Pathways II
Room: Mountain/Lake

Speaker 5 of 5
Matthew D. McGee, Buck Institute for Research on Aging, USA
Short Talk: 3D Digital Atlas of Aging in C. elegans

Monday, February 01 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Monday, February 01 | 8:00PM - 10:00PM
Poster Session 1
Room: Bay


Monday, February 01 | 8:00PM - 9:00PM
Social Hour
Room: Bay


Tuesday, February 02 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, February 02 | 8:00AM - 11:15AM
Molecules and Aging I
Room: Mountain/Lake

Speaker 1 of 7
* David A. Sinclair, Harvard Medical School, USA

Tuesday, February 02 | 8:00AM - 11:15AM
Molecules and Aging I
Room: Mountain/Lake

Speaker 2 of 7
Jan Vijg, Albert Einstein College of Medicine, USA
Genomic Instability, Transcriptional Deregulation and Aging

Tuesday, February 02 | 8:00AM - 11:15AM
Molecules and Aging I
Room: Mountain/Lake

Speaker 3 of 7
Judith Campisi, Buck Institute for Research on Aging, USA
The Double Edged Sword of Cellular Senescence

Tuesday, February 02 | 8:00AM - 11:15AM
Molecules and Aging I
Room: Mountain/Lake

Speaker 4 of 7
George M. Martin, University of Washington, USA
Human diseases of Ageing and their evolutionary substrates

Tuesday, February 02 | 8:00AM - 11:15AM
Molecules and Aging I
Room: Mountain/Lake

Speaker 5 of 7
Norman E. Sharpless, NCI, National Institutes of Health, USA
Cell Cycle Control and Mammalian Aging

Tuesday, February 02 | 8:00AM - 11:15AM
Molecules and Aging I
Room: Mountain/Lake

Speaker 6 of 7
Raul Mostoslavsky, Harvard Medical School, USA
Short Talk: The Histone Deacetylase SIRT6 Functions as a Master Regulator of Glucose Homeostasis

Tuesday, February 02 | 8:00AM - 11:15AM
Molecules and Aging I
Room: Mountain/Lake

Speaker 7 of 7
Eduardo Nunes Chini, Mayo Clinic, USA
Short Talk: CD38 and DBC1: regulators of the non-oxidative functions of NAD; role of inhibitors of the longevity related enzyme SIRT1

Tuesday, February 02 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Tuesday, February 02 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, February 02 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Tuesday, February 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Tuesday, February 02 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Tuesday, February 02 | 5:00PM - 7:00PM
Molecules and Aging II
Room: Mountain/Lake

Speaker 1 of 5
* Jan Vijg, Albert Einstein College of Medicine, USA

Tuesday, February 02 | 5:00PM - 7:00PM
Molecules and Aging II
Room: Mountain/Lake

Speaker 2 of 5
Heidi Scrable, Mayo Clinic, USA
p53 and Aging

Tuesday, February 02 | 5:00PM - 7:00PM
Molecules and Aging II
Room: Mountain/Lake

Speaker 3 of 5
David A. Sinclair, Harvard Medical School, USA
A tale of two Sirts

Tuesday, February 02 | 5:00PM - 7:00PM
Molecules and Aging II
Room: Mountain/Lake

Speaker 4 of 5
Rafael de Cabo, NIA, National Institutes of Health, USA
From Molecules to Nutritional Interventions for Healthy Aging

Tuesday, February 02 | 5:00PM - 7:00PM
Molecules and Aging II
Room: Mountain/Lake

Speaker 5 of 5
* Philipp Oberdoerffer, NCI, National Institutes of Health, USA
Short Talk: A Mechanistic Link between DNA Damage, Chromatin and Aging

Tuesday, February 02 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Tuesday, February 02 | 8:00PM - 10:00PM
Poster Session 2
Room: Bay


Tuesday, February 02 | 8:00PM - 9:00PM
Social Hour
Room: Bay


Wednesday, February 03 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, February 03 | 8:00AM - 11:15AM
Cells and Organelles Aging
Room: Mountain/Lake

Speaker 1 of 7
* Heidi Scrable, Mayo Clinic, USA

Wednesday, February 03 | 8:00AM - 11:15AM
Cells and Organelles Aging
Room: Mountain/Lake

Speaker 2 of 7
Thomas A. Rando, Stanford University School of Medicine, USA
Stem cell aging, DNA damage and asymmetric cell division

Wednesday, February 03 | 8:00AM - 11:15AM
Cells and Organelles Aging
Room: Mountain/Lake

Speaker 3 of 7
Leanne Jones, University of California, Los Angeles, USA
Stem Cell-Niche Cell Interactions during Aging

Wednesday, February 03 | 8:00AM - 11:15AM
Cells and Organelles Aging
Room: Mountain/Lake

Speaker 4 of 7
Amy J. Wagers, Harvard University, USA
Reversing Dysfunction of Aged Tissue Stem Cells

Wednesday, February 03 | 8:00AM - 11:15AM
Cells and Organelles Aging
Room: Mountain/Lake

Speaker 5 of 7
* Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Stem Cell Renewal and changes in stem cell function during aging

Wednesday, February 03 | 8:00AM - 11:15AM
Cells and Organelles Aging
Room: Mountain/Lake

Speaker 6 of 7
Pier Lorenzo Puri, Sanford-Burnham Medical Research Institute, USA
Short Talk: DNA Damage Signaling to MyoD and the Control of the Genomic Stability of Skeletal Muscles during Development and Aging

Wednesday, February 03 | 8:00AM - 11:15AM
Cells and Organelles Aging
Room: Mountain/Lake

Speaker 7 of 7
Giana Angelo, Fred Hutchinson Cancer Research Center, USA
Short Talk: Adult Worms Protect Germline Stem Cells and Extend their Reproductive Span in Response to Starvation

Wednesday, February 03 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Wednesday, February 03 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, February 03 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Wednesday, February 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Wednesday, February 03 | 2:30PM - 4:30PM
Workshop: Stress, Mitochondria, and Aging
Room: Mountain/Lake

Speaker 1 of 7
Nicholas Day, Buck Institute for Research on Aging, USA
A Novel Inducible Mouse Model of Endogenous Mitochondrial Oxidative Stress Causes Heart Disease

Wednesday, February 03 | 2:30PM - 4:30PM
Workshop: Stress, Mitochondria, and Aging
Room: Mountain/Lake

Speaker 2 of 7
Hadise Kabil, University of Michigan, USA
Activity of the Transsulfuration Pathway Determines Lifespan Extension in Response to Dietary Restriction in Drosophila

Wednesday, February 03 | 2:30PM - 4:30PM
Workshop: Stress, Mitochondria, and Aging
Room: Mountain/Lake

Speaker 3 of 7
* Pankaj Kapahi, Buck Institute for Research on Aging, USA
4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

Wednesday, February 03 | 2:30PM - 4:30PM
Workshop: Stress, Mitochondria, and Aging
Room: Mountain/Lake

Speaker 4 of 7
David B. Lombard, University of Michigan, USA
Mitochondrial Protein Acetylation in Calorie Restriction and Aging

Wednesday, February 03 | 2:30PM - 4:30PM
Workshop: Stress, Mitochondria, and Aging
Room: Mountain/Lake

Speaker 5 of 7
Iain Scott, University of Pittsburgh, USA
The Functional Characterization of SIRT3 Modulation of Complex V of the Electron Transfer Chain

Wednesday, February 03 | 2:30PM - 4:30PM
Workshop: Stress, Mitochondria, and Aging
Room: Mountain/Lake

Speaker 6 of 7
Cristiano Simone, Consorzio Mario Negri Sud, Italy
FoxO3A Localizes to Mitochondria and Regulates the Expression of the Mitochondrial Genome in Response to Nutrient Deprivation

Wednesday, February 03 | 2:30PM - 4:30PM
Workshop: Stress, Mitochondria, and Aging
Room: Mountain/Lake

Speaker 7 of 7
Michael C. Velarde, Institute of Biology, Philippines
Superoxide Dismutase 2 Deficiency Promotes Cellular Senescence and Excessive Differentiation in Mouse Epidermis

Wednesday, February 03 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Wednesday, February 03 | 5:00PM - 7:00PM
Cells and Organelles Aging II
Room: Mountain/Lake

Speaker 1 of 5
* Sean M. Oldham, Takeda Pharmaceuticals International Co., USA

Wednesday, February 03 | 5:00PM - 7:00PM
Cells and Organelles Aging II
Room: Mountain/Lake

Speaker 2 of 5
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Autophagy and Aging

Wednesday, February 03 | 5:00PM - 7:00PM
Cells and Organelles Aging II
Room: Mountain/Lake

Speaker 3 of 5
Andrew G. Dillin, University of California, Berkeley, USA
Aging as an Event of Proteostasis Decline

Wednesday, February 03 | 5:00PM - 7:00PM
Cells and Organelles Aging II
Room: Mountain/Lake

Speaker 4 of 5
Michael S. Grotewiel, Virginia Commonwealth University, USA
Age-Related Locomotor Impairment in Drosophila

Wednesday, February 03 | 5:00PM - 7:00PM
Cells and Organelles Aging II
Room: Mountain/Lake

Speaker 5 of 5
Theodore W. Peters, Buck Institute for Research on Aging, USA
Short Talk: Age-Dependent Accumulation of Insoluble Proteins is Conserved Across Taxa

Wednesday, February 03 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Wednesday, February 03 | 8:00PM - 10:00PM
Poster Session 3
Room: Bay


Wednesday, February 03 | 8:00PM - 9:00PM
Social Hour
Room: Bay


Thursday, February 04 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Thursday, February 04 | 8:00AM - 11:15AM
Physiological Systems, Aging and Disease I
Room: Mountain/Lake
Session is Sponsored by The Ellison Medical Foundation
Speaker 1 of 7
* Amy J. Wagers, Harvard University, USA

Thursday, February 04 | 8:00AM - 11:15AM
Physiological Systems, Aging and Disease I
Room: Mountain/Lake
Session is Sponsored by The Ellison Medical Foundation
Speaker 2 of 7
Paul Joseph Shaw, Washington University, USA
Sleep Aging

Thursday, February 04 | 8:00AM - 11:15AM
Physiological Systems, Aging and Disease I
Room: Mountain/Lake
Session is Sponsored by The Ellison Medical Foundation
Speaker 3 of 7
Michael O. Thorner, University of Virginia, USA
Potential Role of Ghrelin Mimetics in Preventing Frailty and Partially Reversing Sarcopenia of Aging

Thursday, February 04 | 8:00AM - 11:15AM
Physiological Systems, Aging and Disease I
Room: Mountain/Lake
Session is Sponsored by The Ellison Medical Foundation
Speaker 4 of 7
Marc Tatar, Brown University, USA
Drosophila as a Model for Analysis of Innate Immune Aging

Thursday, February 04 | 8:00AM - 11:15AM
Physiological Systems, Aging and Disease I
Room: Mountain/Lake
Session is Sponsored by The Ellison Medical Foundation
Speaker 5 of 7
Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Cardiac Aging

Thursday, February 04 | 8:00AM - 11:15AM
Physiological Systems, Aging and Disease I
Room: Mountain/Lake
Session is Sponsored by The Ellison Medical Foundation
Speaker 6 of 7
Matthew Gill, Buck Institute for Research on Aging, USA
Short Talk: Endocannabinoid signaling and aging in C. elegans

Thursday, February 04 | 8:00AM - 11:15AM
Physiological Systems, Aging and Disease I
Room: Mountain/Lake
Session is Sponsored by The Ellison Medical Foundation
Speaker 7 of 7
Richard A. Kerber, University of Louisville, USA
Short Talk: Association of Gene Expression Patterns in Lymphoblastoid Cell Lines with Familial Longevity and Survival

Thursday, February 04 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Thursday, February 04 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Thursday, February 04 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Thursday, February 04 | 5:00PM - 7:00PM
Physiological Systems, Aging and Disease II
Room: Mountain/Lake
Session is Sponsored by The Ellison Medical Foundation
Speaker 1 of 5
* Anne Brunet, Stanford University, USA

Thursday, February 04 | 5:00PM - 7:00PM
Physiological Systems, Aging and Disease II
Room: Mountain/Lake
Session is Sponsored by The Ellison Medical Foundation
Speaker 2 of 5
Monica Driscoll, Rutgers University, USA
Genetic and Pharmacological Extension of Healthspan in a Simple Animal Model

Thursday, February 04 | 5:00PM - 7:00PM
Physiological Systems, Aging and Disease II
Room: Mountain/Lake
Session is Sponsored by The Ellison Medical Foundation
Speaker 3 of 5
Richard A. Miller, University of Michigan, USA
Cell Stress and Aging

Thursday, February 04 | 5:00PM - 7:00PM
Physiological Systems, Aging and Disease II
Room: Mountain/Lake
Session is Sponsored by The Ellison Medical Foundation
Speaker 4 of 5
Bradley J. Willcox, Pacific Health Research Institute, USA
Pathophysiological and Sociopsychological Evidence for Active and Resilient Centenarian

Thursday, February 04 | 5:00PM - 7:00PM
Physiological Systems, Aging and Disease II
Room: Mountain/Lake
Session is Sponsored by The Ellison Medical Foundation
Speaker 5 of 5
Floyd (Ski) Chilton, University of Arizona, USA
Short Talk: Impact of the Varying Frequencies at Common Genetic Variants in the FADS Gene Cluster on Circulating Levels of Inflammatory Fatty Acids in African Americans and Caucasians

Thursday, February 04 | 7:00PM - 8:00PM
Social Hour
Room: Alumni


Thursday, February 04 | 8:00PM - 9:00PM
Dinner
Room: Granhall


Thursday, February 04 | 8:00PM - 11:00PM
Entertainment
Room: Granhall


Friday, February 05 | 10:25AM - 10:25AM
Departure


*Session Chair.