Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Gram-Negative Resistance (2015D1)

Web Desc
Antibiotics and Resistance: Challenges and Solutions Organizer(s): Gerry Wright, Deborah Hung and Stewart L. Fisher Date: February 14 - 19, 2010 Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation For important information on the coronavirus, please click here Summary of Meeting: In the face of a growing crisis in antibiotic resistance and the emergence of new bacterial pathogens, there is a pressing clinical need for new antibiotics. Paradoxically, this call for new drugs comes at a time when investment in antibiotic development in the pharmaceutical industry is at historically low levels. Despite the promise of the genomic revolution to inform drug development and innovations in drug discovery and the fundamental biology that underpins it, modern control of infectious disease with antibiotics is perilously fragile. This meeting brings together researchers from medicine, academe and industry and from across scientific disciplines to discuss the challenges of antibiotic development in the 21st Century. What is the scope of the problem? What are possible solutions? What are the imperatives for the short and long term and is the traditional antibiotic paradigm in need of an overhaul? These questions will be the focus of the meeting that will help to define the problems and solutions in antibiotic development. Global Health Travel Award Deadline: September 8 2009 Scholarship Deadline: October 14 2009 Discounted Abstract Deadline: October 14 2009 Abstract Deadline: November 13 2009 Discounted Registration Deadline: December 14 2009 We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: AstraZeneca R&D Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Novartis Institutes for BioMedical Research We gratefully acknowledge the generous grant for this conference provided by: National Institute of Allergy and Infectious Diseases (NIAID) Grant No. 1R13AI085733-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Antibiotics and Resistance: Challenges and Solutions

Organizer(s): Gerry Wright, Deborah Hung and Stewart L. Fisher

Date: February 14 - 19, 2010
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA

Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation

For important information on the coronavirus, please click here

Summary of Meeting:

In the face of a growing crisis in antibiotic resistance and the emergence of new bacterial pathogens, there is a pressing clinical need for new antibiotics. Paradoxically, this call for new drugs comes at a time when investment in antibiotic development in the pharmaceutical industry is at historically low levels. Despite the promise of the genomic revolution to inform drug development and innovations in drug discovery and the fundamental biology that underpins it, modern control of infectious disease with antibiotics is perilously fragile. This meeting brings together researchers from medicine, academe and industry and from across scientific disciplines to discuss the challenges of antibiotic development in the 21st Century. What is the scope of the problem? What are possible solutions? What are the imperatives for the short and long term and is the traditional antibiotic paradigm in need of an overhaul? These questions will be the focus of the meeting that will help to define the problems and solutions in antibiotic development.

Global Health Travel Award Deadline: September 8 2009

Scholarship Deadline: October 14 2009

Discounted Abstract Deadline: October 14 2009

Abstract Deadline: November 13 2009

Discounted Registration Deadline: December 14 2009

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

AstraZeneca R&D

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

Novartis Institutes for BioMedical Research

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI085733-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, February 14 \| 3:00PM - 7:30PM Registration Room: Promenade
Sunday, February 14 \| 6:30PM - 7:30PM Refreshments Room: Promenade
Sunday, February 14 \| 7:30PM - 8:30PM Keynote Address Room: Mesa A-B Speaker 1 of 2 * Gerry D. Wright, McMaster University, Canada
Sunday, February 14 \| 7:30PM - 8:30PM Keynote Address Room: Mesa A-B Speaker 2 of 2 Patrice Courvalin, Institut Pasteur, France Evolution and Dissemination of Antibiotic Resistance: The Glycopeptide Model the Van Saga
Monday, February 15 \| 7:00AM - 8:00AM Breakfast Room: Chamisa
Monday, February 15 \| 8:00AM - 11:00AM The Problem of Antibiotic Resistance and the Need for New Dr ugs Room: Mesa A-B Speaker 1 of 5 * Julian E. Davies, University of British Columbia, Canada
Monday, February 15 \| 8:00AM - 11:00AM The Problem of Antibiotic Resistance and the Need for New Dr ugs Room: Mesa A-B Speaker 2 of 5 Donald E. Low, Mount Sinai Hospital, Canada Bacterial Pathogens in the Hospital and Community: The need for New Antibiotics
Monday, February 15 \| 8:00AM - 11:00AM The Problem of Antibiotic Resistance and the Need for New Dr ugs Room: Mesa A-B Speaker 3 of 5 Valerie Mizrahi, University of Cape Town, South Africa New Tools for Tuberculosis Drug Discovery: Development of Novel Screening Strains of Mycobacterium tuberculosis and Application in Target-Based Approaches
Monday, February 15 \| 8:00AM - 11:00AM The Problem of Antibiotic Resistance and the Need for New Dr ugs Room: Mesa A-B Speaker 4 of 5 Michael G. Surette, University of Calgary, Canada The Clinical Challenge and Opportunities of Microbial Communities
Monday, February 15 \| 8:00AM - 11:00AM The Problem of Antibiotic Resistance and the Need for New Dr ugs Room: Mesa A-B Speaker 5 of 5 Gerry D. Wright, McMaster University, Canada Antibiotic Resistance: Where Does it Come from and What Can We Do About it?
Monday, February 15 \| 9:20AM - 9:40AM Coffee Break Room: Promenade
Monday, February 15 \| 11:00AM - 11:00AM On Own for Lunch and Recreation
Monday, February 15 \| 1:00PM - 10:00PM Poster Viewing Room: Mesa C/Chamisa
Monday, February 15 \| 4:30PM - 5:00PM Coffee Available Room: Promenade
Monday, February 15 \| 5:00PM - 7:00PM Success and Barriers in Modern Antibacterial Drug Discovery Room: Mesa A-B Speaker 1 of 4 * Stewart L. Fisher, C4 Therapeutics, Inc, USA
Monday, February 15 \| 5:00PM - 7:00PM Success and Barriers in Modern Antibacterial Drug Discovery Room: Mesa A-B Speaker 2 of 4 Julian E. Davies, University of British Columbia, Canada Where will New Antibiotics Come From?
Monday, February 15 \| 5:00PM - 7:00PM Success and Barriers in Modern Antibacterial Drug Discovery Room: Mesa A-B Speaker 3 of 4 Mike Barbachyn, AstraZeneca Pharmaceuticals LP, USA The Natural History of the Oxazolidinones
Monday, February 15 \| 5:00PM - 7:00PM Success and Barriers in Modern Antibacterial Drug Discovery Room: Mesa A-B Speaker 4 of 4 Patricia Bradford, Novartis Institutes for BioMedical Research, USA Difficulties and Success in Bringing the 3rd Generation Tetracyclines to Market: The Story of Tigecycline
Monday, February 15 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Chamisa
Monday, February 15 \| 7:30PM - 10:00PM Poster Session 1 Room: Mesa C/Chamisa
Tuesday, February 16 \| 7:00AM - 8:00AM Breakfast Room: Chamisa
Tuesday, February 16 \| 8:00AM - 11:00AM Mining Known Pathways as Targets for New Antibiotics Room: Mesa A-B Speaker 1 of 6 * Deborah T. Hung, Broad Institute of MIT & Harvard, USA
Tuesday, February 16 \| 8:00AM - 11:00AM Mining Known Pathways as Targets for New Antibiotics Room: Mesa A-B Speaker 2 of 6 Stewart L. Fisher, C4 Therapeutics, Inc, USA DNA Replication: Challenges and Opportunities
Tuesday, February 16 \| 8:00AM - 11:00AM Mining Known Pathways as Targets for New Antibiotics Room: Mesa A-B Speaker 3 of 6 Jennifer Campbell, Harvard Medical School, USA Small Molecule Inhibitors of Wall Tecoic Acid Biosynthesis and their Effects on Staphylococcus aureus
Tuesday, February 16 \| 8:00AM - 11:00AM Mining Known Pathways as Targets for New Antibiotics Room: Mesa A-B Speaker 4 of 6 Peter J. Tonge, Stony Brook University, USA Slow Onset Inhibitors of Bacterial Fatty Acid Biosynthesis:Slow Onset Inhibition, Residence Time and in Vivo Activity
Tuesday, February 16 \| 8:00AM - 11:00AM Mining Known Pathways as Targets for New Antibiotics Room: Mesa A-B Speaker 5 of 6 Thomas A. Steitz, Howard Hughes Medical Institute, Yale University, USA From the Structures of Ribosome-Antibiotic Complexes to New Antibiotics
Tuesday, February 16 \| 8:00AM - 11:00AM Mining Known Pathways as Targets for New Antibiotics Room: Mesa A-B Speaker 6 of 6 Ronald W. Woodard, University of Michigan, USA Short Talk: HTS Assay Developments in the KDO Biosynthesis Pathway
Tuesday, February 16 \| 9:20AM - 9:40AM Coffee Break Room: Promenade
Tuesday, February 16 \| 11:00AM - 11:00AM On Own for Lunch and Recreation
Tuesday, February 16 \| 1:00PM - 10:00PM Poster Viewing Room: Mesa C/Chamisa
Tuesday, February 16 \| 4:30PM - 5:00PM Coffee Available Room: Promenade
Tuesday, February 16 \| 5:00PM - 7:00PM New Molecules for New (and Old) Challenges Room: Mesa A-B Speaker 1 of 5 * Eric D. Brown, McMaster University, Canada
Tuesday, February 16 \| 5:00PM - 7:00PM New Molecules for New (and Old) Challenges Room: Mesa A-B Speaker 2 of 5 Christopher T. Walsh, Harvard Medical School, USA Biosynthesis of Thiazolyl Peptide Antibiotics: a Bevi of Posttranslational Maturations
Tuesday, February 16 \| 5:00PM - 7:00PM New Molecules for New (and Old) Challenges Room: Mesa A-B Speaker 3 of 5 Mark J. Macielag, Johnson & Johnson Pharmaceutical Research & Development, USA What Makes a Good Antibiotic? The Chemistry Perspective.
Tuesday, February 16 \| 5:00PM - 7:00PM New Molecules for New (and Old) Challenges Room: Mesa A-B Speaker 4 of 5 Chris Abell, University of Cambridge, UK Application of Fragment-Based Approaches to the Discovery of New Agents Against Mycobacterium tuberculosis
Tuesday, February 16 \| 5:00PM - 7:00PM New Molecules for New (and Old) Challenges Room: Mesa A-B Speaker 5 of 5 Mervyn Bibb, John Innes Centre, UK Short Talk: Actinomycete Lantibiotics: An Untapped Clinical Resource?
Tuesday, February 16 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Chamisa
Tuesday, February 16 \| 7:30PM - 10:00PM Poster Session 2 Room: Mesa C/Chamisa
Wednesday, February 17 \| 7:00AM - 8:00AM Breakfast Room: Chamisa
Wednesday, February 17 \| 8:00AM - 11:00AM New Antibiotic Targets - Virulence and Quorum Sensing Room: Mesa A-B Speaker 1 of 5 * Michael G. Surette, University of Calgary, Canada
Wednesday, February 17 \| 8:00AM - 11:00AM New Antibiotic Targets - Virulence and Quorum Sensing Room: Mesa A-B Speaker 2 of 5 Robert E.W. Hancock, University of British Columbia, Canada Modulation of Host Immunity as an Anti-Infective Strategy
Wednesday, February 17 \| 8:00AM - 11:00AM New Antibiotic Targets - Virulence and Quorum Sensing Room: Mesa A-B Speaker 3 of 5 Helen E. Blackwell, University of Wisconsin-Madison, USA Expanding the Language of Bacterial Quorum Sensing using Synthetic Ligands
Wednesday, February 17 \| 8:00AM - 11:00AM New Antibiotic Targets - Virulence and Quorum Sensing Room: Mesa A-B Speaker 4 of 5 Vincent T. Lee, University of Maryland, USA Are Type 3 Secretion Systems Good Targets for Antimicrobials?
Wednesday, February 17 \| 8:00AM - 11:00AM New Antibiotic Targets - Virulence and Quorum Sensing Room: Mesa A-B Speaker 5 of 5 Scott Hultgren, Washington University School of Medicine, USA Bacterial Adhesion and Biofilm Formation - A Source of Alternate Antibiotic Targets
Wednesday, February 17 \| 9:20AM - 9:40AM Coffee Break Room: Promenade
Wednesday, February 17 \| 11:00AM - 11:00AM On Own for Lunch and Recreation
Wednesday, February 17 \| 4:30PM - 5:00PM Coffee Available Room: Promenade
Wednesday, February 17 \| 5:00PM - 7:00PM New Technology - Systems and Synthetic Biology Room: Mesa A-B Speaker 1 of 4 * Stewart L. Fisher, C4 Therapeutics, Inc, USA
Wednesday, February 17 \| 5:00PM - 7:00PM New Technology - Systems and Synthetic Biology Room: Mesa A-B Speaker 2 of 4 Eric D. Brown, McMaster University, Canada Chemical Genomics: Charting Chemical-Genetic Interactions in Bacteria
Wednesday, February 17 \| 5:00PM - 7:00PM New Technology - Systems and Synthetic Biology Room: Mesa A-B Speaker 3 of 4 Frederick M. Ausubel, Massachusetts General Hospital, USA Whole Organism Antibiotic Screening in C. elegans
Wednesday, February 17 \| 5:00PM - 7:00PM New Technology - Systems and Synthetic Biology Room: Mesa A-B Speaker 4 of 4 * Deborah T. Hung, Broad Institute of MIT & Harvard, USA Antivirulence Therapy
Wednesday, February 17 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Chamisa
Thursday, February 18 \| 7:00AM - 8:00AM Breakfast Room: Chamisa
Thursday, February 18 \| 8:00AM - 11:00AM New Technology - Real Time Diagnostics and Narrow vs. Broad Spectrum Agents Room: Mesa A-B Speaker 1 of 5 * Gerry D. Wright, McMaster University, Canada
Thursday, February 18 \| 8:00AM - 11:00AM New Technology - Real Time Diagnostics and Narrow vs. Broad Spectrum Agents Room: Mesa A-B Speaker 2 of 5 Sylvie Garneau-Tsodikova, University of Michigan, USA Turning an Aminoglycoside Resistance Problem into a Solution: New Approaches to Chemoenzymatic Synthesis of Antibiotics
Thursday, February 18 \| 8:00AM - 11:00AM New Technology - Real Time Diagnostics and Narrow vs. Broad Spectrum Agents Room: Mesa A-B Speaker 3 of 5 Roy Kishony, Technion – Israel Institute of Technology, Israel Inverting the Selective Advantage of Antibiotic Resistance
Thursday, February 18 \| 8:00AM - 11:00AM New Technology - Real Time Diagnostics and Narrow vs. Broad Spectrum Agents Room: Mesa A-B Speaker 4 of 5 Jose Miguel Trevejo, Draper Laboratory/Beth Isreal Deaconess Boston, USA Novel Sensors and Diagnostics for Rapid Identification of Microbial Resistance
Thursday, February 18 \| 8:00AM - 11:00AM New Technology - Real Time Diagnostics and Narrow vs. Broad Spectrum Agents Room: Mesa A-B Speaker 5 of 5 Vincent A. Fischetti, Rockefeller University, USA Using What Phage Have Learned to Kill Gram-Positive Bacteria
Thursday, February 18 \| 9:20AM - 9:40AM Coffee Break Room: Promenade
Thursday, February 18 \| 11:00AM - 11:00AM On Own for Lunch and Recreation
Thursday, February 18 \| 2:30PM - 4:30PM Workshop: Submitted Papers Room: Mesa A-B Speaker 1 of 7 * Stewart L. Fisher, C4 Therapeutics, Inc, USA
Thursday, February 18 \| 2:30PM - 4:30PM Workshop: Submitted Papers Room: Mesa A-B Speaker 2 of 7 Bart Staker, Center for Infectious Disease Research, USA Ligand Screening at the Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Thursday, February 18 \| 2:30PM - 4:30PM Workshop: Submitted Papers Room: Mesa A-B Speaker 3 of 7 Aileen Rubio, Spero Therapeutics, USA Frequency and Distribution of Mutations in mprF in Daptomycin Nonsusceptible Staphylococcus aureus Clinical Isolates
Thursday, February 18 \| 2:30PM - 4:30PM Workshop: Submitted Papers Room: Mesa A-B Speaker 4 of 7 Adriana Renzoni, University Hospital and Medical School of Geneva, Switzerland Total Genome Sequencing and Complete Genetic Analysis of all SNP-Linked Phenotypes Reveals Novel Clues to the Emergence of Low Level Glycopeptide Intermediate Resistance in Staphylococcus aureus
Thursday, February 18 \| 2:30PM - 4:30PM Workshop: Submitted Papers Room: Mesa A-B Speaker 5 of 7 Terence I. Moy, Cubist Pharmaceuticals, USA High Rates of Resistance to Three Classes of RNA Polymerase Inhibitors in Staphylococcus aureus
Thursday, February 18 \| 2:30PM - 4:30PM Workshop: Submitted Papers Room: Mesa A-B Speaker 6 of 7 Donald T. Moir, Microbiotix, Inc., USA Characterization of a Stereo-Specific Class of Inhibitors of Type-Three Secretion
Thursday, February 18 \| 2:30PM - 4:30PM Workshop: Submitted Papers Room: Mesa A-B Speaker 7 of 7 Dickon Alley, Anacor Pharmaceuticals, Inc., USA Structure-Guided Discovery of ABX a 3-Aminomethyl Benzoxaborole: A First in Class Antibacterial for Gram-Negative Bacterial Infections
Thursday, February 18 \| 4:30PM - 5:00PM Coffee Available Room: Promenade
Thursday, February 18 \| 5:00PM - 7:00PM What about the Host? Room: Mesa A-B Speaker 1 of 3 * Deborah T. Hung, Broad Institute of MIT & Harvard, USA
Thursday, February 18 \| 5:00PM - 7:00PM What about the Host? Room: Mesa A-B Speaker 2 of 3 David A. Relman, Stanford University, USA The Human Microbiome: Antibiotic Perturbation, Response, and Human Health
Thursday, February 18 \| 5:00PM - 7:00PM What about the Host? Room: Mesa A-B Speaker 3 of 3 Dana Philpott, University of Toronto, Canada Nod-like Receptors in Immunity, Inflamation and Disease
Thursday, February 18 \| 8:00PM - 9:00PM Social Hour with Lite Bites Room: Mesa Ballroom
Thursday, February 18 \| 8:00PM - 11:00PM Entertainment Room: Mesa Ballroom
Thursday, February 18 \| 9:00PM - 11:00PM Cash Bar Room: Mesa Ballroom
Friday, February 19 \| 10:22AM - 10:22AM Departure *Session Chair †Invited, not yet responded.