Web Desc
Antibiotics and Resistance: Challenges and Solutions
Organizer(s): Gerry Wright, Deborah Hung and Stewart L. Fisher
Date: February 14 - 19, 2010
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation
For important information on the coronavirus, please click here
Summary of Meeting:
In the face of a growing crisis in antibiotic resistance and the emergence of new bacterial pathogens, there is a pressing clinical need for new antibiotics. Paradoxically, this call for new drugs comes at a time when investment in antibiotic development in the pharmaceutical industry is at historically low levels. Despite the promise of the genomic revolution to inform drug development and innovations in drug discovery and the fundamental biology that underpins it, modern control of infectious disease with antibiotics is perilously fragile. This meeting brings together researchers from medicine, academe and industry and from across scientific disciplines to discuss the challenges of antibiotic development in the 21st Century. What is the scope of the problem? What are possible solutions? What are the imperatives for the short and long term and is the traditional antibiotic paradigm in need of an overhaul? These questions will be the focus of the meeting that will help to define the problems and solutions in antibiotic development.
Global Health Travel Award Deadline: September 8 2009
Scholarship Deadline: October 14 2009
Discounted Abstract Deadline: October 14 2009
Abstract Deadline: November 13 2009
Discounted Registration Deadline: December 14 2009
We gratefully acknowledge additional support for this conference from:
Bill & Melinda Gates Foundation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

AstraZeneca R&D

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

Novartis Institutes for BioMedical Research
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI085733-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 14 | 3:00PM - 7:30PM
Registration
Room: Promenade


Sunday, February 14 | 6:30PM - 7:30PM
Refreshments
Room: Promenade


Sunday, February 14 | 7:30PM - 8:30PM
Keynote Address
Room: Mesa A-B

Speaker 1 of 2
* Gerry D. Wright, McMaster University, Canada

Sunday, February 14 | 7:30PM - 8:30PM
Keynote Address
Room: Mesa A-B

Speaker 2 of 2
Patrice Courvalin, Institut Pasteur, France
Evolution and Dissemination of Antibiotic Resistance: The Glycopeptide Model the Van Saga

Monday, February 15 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Monday, February 15 | 8:00AM - 11:00AM
The Problem of Antibiotic Resistance and the Need for New Dr
ugs

Room: Mesa A-B

Speaker 1 of 5
* Julian E. Davies, University of British Columbia, Canada

Monday, February 15 | 8:00AM - 11:00AM
The Problem of Antibiotic Resistance and the Need for New Dr
ugs

Room: Mesa A-B

Speaker 2 of 5
Donald E. Low, Mount Sinai Hospital, Canada
Bacterial Pathogens in the Hospital and Community: The need for New Antibiotics

Monday, February 15 | 8:00AM - 11:00AM
The Problem of Antibiotic Resistance and the Need for New Dr
ugs

Room: Mesa A-B

Speaker 3 of 5
Valerie Mizrahi, University of Cape Town, South Africa
New Tools for Tuberculosis Drug Discovery: Development of Novel Screening Strains of Mycobacterium tuberculosis and Application in Target-Based Approaches

Monday, February 15 | 8:00AM - 11:00AM
The Problem of Antibiotic Resistance and the Need for New Dr
ugs

Room: Mesa A-B

Speaker 4 of 5
Michael G. Surette, University of Calgary, Canada
The Clinical Challenge and Opportunities of Microbial Communities

Monday, February 15 | 8:00AM - 11:00AM
The Problem of Antibiotic Resistance and the Need for New Dr
ugs

Room: Mesa A-B

Speaker 5 of 5
Gerry D. Wright, McMaster University, Canada
Antibiotic Resistance: Where Does it Come from and What Can We Do About it?

Monday, February 15 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Monday, February 15 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Monday, February 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C/Chamisa


Monday, February 15 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Monday, February 15 | 5:00PM - 7:00PM
Success and Barriers in Modern Antibacterial Drug Discovery
Room: Mesa A-B

Speaker 1 of 4
* Stewart L. Fisher, C4 Therapeutics, Inc, USA

Monday, February 15 | 5:00PM - 7:00PM
Success and Barriers in Modern Antibacterial Drug Discovery
Room: Mesa A-B

Speaker 2 of 4
Julian E. Davies, University of British Columbia, Canada
Where will New Antibiotics Come From?

Monday, February 15 | 5:00PM - 7:00PM
Success and Barriers in Modern Antibacterial Drug Discovery
Room: Mesa A-B

Speaker 3 of 4
Mike Barbachyn, AstraZeneca Pharmaceuticals LP, USA
The Natural History of the Oxazolidinones

Monday, February 15 | 5:00PM - 7:00PM
Success and Barriers in Modern Antibacterial Drug Discovery
Room: Mesa A-B

Speaker 4 of 4
Patricia Bradford, Novartis Institutes for BioMedical Research, USA
Difficulties and Success in Bringing the 3rd Generation Tetracyclines to Market: The Story of Tigecycline

Monday, February 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa


Monday, February 15 | 7:30PM - 10:00PM
Poster Session 1
Room: Mesa C/Chamisa


Tuesday, February 16 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Tuesday, February 16 | 8:00AM - 11:00AM
Mining Known Pathways as Targets for New Antibiotics
Room: Mesa A-B

Speaker 1 of 6
* Deborah T. Hung, Broad Institute of MIT & Harvard, USA

Tuesday, February 16 | 8:00AM - 11:00AM
Mining Known Pathways as Targets for New Antibiotics
Room: Mesa A-B

Speaker 2 of 6
Stewart L. Fisher, C4 Therapeutics, Inc, USA
DNA Replication: Challenges and Opportunities

Tuesday, February 16 | 8:00AM - 11:00AM
Mining Known Pathways as Targets for New Antibiotics
Room: Mesa A-B

Speaker 3 of 6
Jennifer Campbell, Harvard Medical School, USA
Small Molecule Inhibitors of Wall Tecoic Acid Biosynthesis and their Effects on Staphylococcus aureus

Tuesday, February 16 | 8:00AM - 11:00AM
Mining Known Pathways as Targets for New Antibiotics
Room: Mesa A-B

Speaker 4 of 6
Peter J. Tonge, Stony Brook University, USA
Slow Onset Inhibitors of Bacterial Fatty Acid Biosynthesis:Slow Onset Inhibition, Residence Time and in Vivo Activity

Tuesday, February 16 | 8:00AM - 11:00AM
Mining Known Pathways as Targets for New Antibiotics
Room: Mesa A-B

Speaker 5 of 6
Thomas A. Steitz, Howard Hughes Medical Institute, Yale University, USA
From the Structures of Ribosome-Antibiotic Complexes to New Antibiotics

Tuesday, February 16 | 8:00AM - 11:00AM
Mining Known Pathways as Targets for New Antibiotics
Room: Mesa A-B

Speaker 6 of 6
Ronald W. Woodard, University of Michigan, USA
Short Talk: HTS Assay Developments in the KDO Biosynthesis Pathway

Tuesday, February 16 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Tuesday, February 16 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Tuesday, February 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C/Chamisa


Tuesday, February 16 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Tuesday, February 16 | 5:00PM - 7:00PM
New Molecules for New (and Old) Challenges
Room: Mesa A-B

Speaker 1 of 5
* Eric D. Brown, McMaster University, Canada

Tuesday, February 16 | 5:00PM - 7:00PM
New Molecules for New (and Old) Challenges
Room: Mesa A-B

Speaker 2 of 5
Christopher T. Walsh, Harvard Medical School, USA
Biosynthesis of Thiazolyl Peptide Antibiotics: a Bevi of Posttranslational Maturations

Tuesday, February 16 | 5:00PM - 7:00PM
New Molecules for New (and Old) Challenges
Room: Mesa A-B

Speaker 3 of 5
Mark J. Macielag, Johnson & Johnson Pharmaceutical Research & Development, USA
What Makes a Good Antibiotic? The Chemistry Perspective.

Tuesday, February 16 | 5:00PM - 7:00PM
New Molecules for New (and Old) Challenges
Room: Mesa A-B

Speaker 4 of 5
Chris Abell, University of Cambridge, UK
Application of Fragment-Based Approaches to the Discovery of New Agents Against Mycobacterium tuberculosis

Tuesday, February 16 | 5:00PM - 7:00PM
New Molecules for New (and Old) Challenges
Room: Mesa A-B

Speaker 5 of 5
Mervyn Bibb, John Innes Centre, UK
Short Talk: Actinomycete Lantibiotics: An Untapped Clinical Resource?

Tuesday, February 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa


Tuesday, February 16 | 7:30PM - 10:00PM
Poster Session 2
Room: Mesa C/Chamisa


Wednesday, February 17 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Wednesday, February 17 | 8:00AM - 11:00AM
New Antibiotic Targets - Virulence and Quorum Sensing
Room: Mesa A-B

Speaker 1 of 5
* Michael G. Surette, University of Calgary, Canada

Wednesday, February 17 | 8:00AM - 11:00AM
New Antibiotic Targets - Virulence and Quorum Sensing
Room: Mesa A-B

Speaker 2 of 5
Robert E.W. Hancock, University of British Columbia, Canada
Modulation of Host Immunity as an Anti-Infective Strategy

Wednesday, February 17 | 8:00AM - 11:00AM
New Antibiotic Targets - Virulence and Quorum Sensing
Room: Mesa A-B

Speaker 3 of 5
Helen E. Blackwell, University of Wisconsin-Madison, USA
Expanding the Language of Bacterial Quorum Sensing using Synthetic Ligands

Wednesday, February 17 | 8:00AM - 11:00AM
New Antibiotic Targets - Virulence and Quorum Sensing
Room: Mesa A-B

Speaker 4 of 5
Vincent T. Lee, University of Maryland, USA
Are Type 3 Secretion Systems Good Targets for Antimicrobials?

Wednesday, February 17 | 8:00AM - 11:00AM
New Antibiotic Targets - Virulence and Quorum Sensing
Room: Mesa A-B

Speaker 5 of 5
Scott Hultgren, Washington University School of Medicine, USA
Bacterial Adhesion and Biofilm Formation - A Source of Alternate Antibiotic Targets

Wednesday, February 17 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Wednesday, February 17 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Wednesday, February 17 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Wednesday, February 17 | 5:00PM - 7:00PM
New Technology - Systems and Synthetic Biology
Room: Mesa A-B

Speaker 1 of 4
* Stewart L. Fisher, C4 Therapeutics, Inc, USA

Wednesday, February 17 | 5:00PM - 7:00PM
New Technology - Systems and Synthetic Biology
Room: Mesa A-B

Speaker 2 of 4
Eric D. Brown, McMaster University, Canada
Chemical Genomics: Charting Chemical-Genetic Interactions in Bacteria

Wednesday, February 17 | 5:00PM - 7:00PM
New Technology - Systems and Synthetic Biology
Room: Mesa A-B

Speaker 3 of 4
Frederick M. Ausubel, Massachusetts General Hospital, USA
Whole Organism Antibiotic Screening in C. elegans

Wednesday, February 17 | 5:00PM - 7:00PM
New Technology - Systems and Synthetic Biology
Room: Mesa A-B

Speaker 4 of 4
* Deborah T. Hung, Broad Institute of MIT & Harvard, USA
Antivirulence Therapy

Wednesday, February 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa


Thursday, February 18 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Thursday, February 18 | 8:00AM - 11:00AM
New Technology - Real Time Diagnostics and Narrow vs. Broad
Spectrum Agents

Room: Mesa A-B

Speaker 1 of 5
* Gerry D. Wright, McMaster University, Canada

Thursday, February 18 | 8:00AM - 11:00AM
New Technology - Real Time Diagnostics and Narrow vs. Broad
Spectrum Agents

Room: Mesa A-B

Speaker 2 of 5
Sylvie Garneau-Tsodikova, University of Michigan, USA
Turning an Aminoglycoside Resistance Problem into a Solution: New Approaches to Chemoenzymatic Synthesis of Antibiotics

Thursday, February 18 | 8:00AM - 11:00AM
New Technology - Real Time Diagnostics and Narrow vs. Broad
Spectrum Agents

Room: Mesa A-B

Speaker 3 of 5
Roy Kishony, Technion – Israel Institute of Technology, Israel
Inverting the Selective Advantage of Antibiotic Resistance

Thursday, February 18 | 8:00AM - 11:00AM
New Technology - Real Time Diagnostics and Narrow vs. Broad
Spectrum Agents

Room: Mesa A-B

Speaker 4 of 5
Jose Miguel Trevejo, Draper Laboratory/Beth Isreal Deaconess Boston, USA
Novel Sensors and Diagnostics for Rapid Identification of Microbial Resistance

Thursday, February 18 | 8:00AM - 11:00AM
New Technology - Real Time Diagnostics and Narrow vs. Broad
Spectrum Agents

Room: Mesa A-B

Speaker 5 of 5
Vincent A. Fischetti, Rockefeller University, USA
Using What Phage Have Learned to Kill Gram-Positive Bacteria

Thursday, February 18 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Thursday, February 18 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Thursday, February 18 | 2:30PM - 4:30PM
Workshop: Submitted Papers
Room: Mesa A-B

Speaker 1 of 7
* Stewart L. Fisher, C4 Therapeutics, Inc, USA

Thursday, February 18 | 2:30PM - 4:30PM
Workshop: Submitted Papers
Room: Mesa A-B

Speaker 2 of 7
Bart Staker, Center for Infectious Disease Research, USA
Ligand Screening at the Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Thursday, February 18 | 2:30PM - 4:30PM
Workshop: Submitted Papers
Room: Mesa A-B

Speaker 3 of 7
Aileen Rubio, Spero Therapeutics, USA
Frequency and Distribution of Mutations in mprF in Daptomycin Nonsusceptible Staphylococcus aureus Clinical Isolates

Thursday, February 18 | 2:30PM - 4:30PM
Workshop: Submitted Papers
Room: Mesa A-B

Speaker 4 of 7
Adriana Renzoni, University Hospital and Medical School of Geneva, Switzerland
Total Genome Sequencing and Complete Genetic Analysis of all SNP-Linked Phenotypes Reveals Novel Clues to the Emergence of Low Level Glycopeptide Intermediate Resistance in Staphylococcus aureus

Thursday, February 18 | 2:30PM - 4:30PM
Workshop: Submitted Papers
Room: Mesa A-B

Speaker 5 of 7
Terence I. Moy, Cubist Pharmaceuticals, USA
High Rates of Resistance to Three Classes of RNA Polymerase Inhibitors in Staphylococcus aureus

Thursday, February 18 | 2:30PM - 4:30PM
Workshop: Submitted Papers
Room: Mesa A-B

Speaker 6 of 7
Donald T. Moir, Microbiotix, Inc., USA
Characterization of a Stereo-Specific Class of Inhibitors of Type-Three Secretion

Thursday, February 18 | 2:30PM - 4:30PM
Workshop: Submitted Papers
Room: Mesa A-B

Speaker 7 of 7
Dickon Alley, Anacor Pharmaceuticals, Inc., USA
Structure-Guided Discovery of ABX a 3-Aminomethyl Benzoxaborole: A First in Class Antibacterial for Gram-Negative Bacterial Infections

Thursday, February 18 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Thursday, February 18 | 5:00PM - 7:00PM
What about the Host?
Room: Mesa A-B

Speaker 1 of 3
* Deborah T. Hung, Broad Institute of MIT & Harvard, USA

Thursday, February 18 | 5:00PM - 7:00PM
What about the Host?
Room: Mesa A-B

Speaker 2 of 3
David A. Relman, Stanford University, USA
The Human Microbiome: Antibiotic Perturbation, Response, and Human Health

Thursday, February 18 | 5:00PM - 7:00PM
What about the Host?
Room: Mesa A-B

Speaker 3 of 3
Dana Philpott, University of Toronto, Canada
Nod-like Receptors in Immunity, Inflamation and Disease

Thursday, February 18 | 8:00PM - 9:00PM
Social Hour with Lite Bites
Room: Mesa Ballroom


Thursday, February 18 | 8:00PM - 11:00PM
Entertainment
Room: Mesa Ballroom


Thursday, February 18 | 9:00PM - 11:00PM
Cash Bar
Room: Mesa Ballroom


Friday, February 19 | 10:22AM - 10:22AM
Departure


*Session Chair
†Invited, not yet responded.