Web Desc
Tolerance and Autoimmunity
Organizer(s): Betty Diamond and Diane J. Mathis
Date: February 21 - 26, 2010
Location: Taos Convention Center (meeting only), Taos, NM, USA
Sponsored by Novo Nordisk A/S
Summary of Meeting:
Elegant studies of central T and B cell tolerance have been performed, leading to the identification of multiple mechanisms that remove or silence autoreactive cells during their maturation, but also reminding us that some autoreactive cells do mature to immunocompetence in all individuals. Furthermore, studies of the B cell response to antigen have clearly demonstrated that autoreactivity can arise de novo in antigen-activated cells, which also requires silencing. Finally, it has now been established in studies of multiple autoimmune diseases that a critical checkpoint exists between autoreactivity and tissue injury, one of the issues about which we remain most ignorant. Understanding peripheral mechanisms for maintaining self-tolerance offers promise for better therapies for autoimmune disease. The proper implementation of this new knowledge requires an understanding of similarities and differences between animal models and human disease. Specific Issues: • Translating results from studies of animal models to human studies • Peripheral and central tolerance • T cells and B cells • The relationship between autoimmunity and immunodeficiency • The role of dendritic cells in autoimmunity • What dictates generation of autoreactive antibody in one individual and not in another? • How much autoreactivity must occur in order to progress to disease and what governs this? • What exactly is 'pathogenic autoreactivity', i.e, are all investigators talking about the same thing? • How much of pathogenesis is due to autoreacting antibodies per se versus the tissue's response to antibody? • What role is innate immunity playing in all of this?
Scholarship Deadline: October 21 2009
Discounted Abstract Deadline: October 21 2009
Abstract Deadline: November 20 2009
Discounted Registration Deadline: December 21 2009
We gratefully acknowledge additional support for this conference from:
JDRFNovo Nordisk A/S
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.


Kimberly Payne
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI085738-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 21 | 3:00PM - 7:30PM
Registration
Room: Rio Grande A


Sunday, February 21 | 6:30PM - 7:30PM
Refreshments
Room: Rio Grande A


Sunday, February 21 | 7:30PM - 8:30PM
Keynote Address
Room: Bataan

Speaker 1 of 1
Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
T cells in the framework of immunological tolerance

Monday, February 22 | 7:00AM - 8:00AM
Breakfast
Room: Rio Grande B,C,D


Monday, February 22 | 8:00AM - 11:00AM
Signaling Negative Selection of Autoreactive Lymphocytes
Room: Bataan

Speaker 1 of 5
Chang-Zheng Chen, Stanford University, USA
Immune Modulation: Lessons and Puzzles from the miR81 Family of Genes

Monday, February 22 | 8:00AM - 11:00AM
Signaling Negative Selection of Autoreactive Lymphocytes
Room: Bataan

Speaker 2 of 5
* Eric M. Verdin, Buck Institute for Research on Aging, USA
HDAC7 and Autoimmunity

Monday, February 22 | 8:00AM - 11:00AM
Signaling Negative Selection of Autoreactive Lymphocytes
Room: Bataan

Speaker 3 of 5
Philippe Bouillet, Walter and Eliza Hall Institute of Medical Research, Australia
Bim Kills Cells Mostly by Inhibiting the Bcl-2 Pro-Survival Proteins

Monday, February 22 | 8:00AM - 11:00AM
Signaling Negative Selection of Autoreactive Lymphocytes
Room: Bataan

Speaker 4 of 5
Jane H. Buckner, Benaroya Research Institute at Virginia Mason, USA
Blunted BCR Signaling, a Source of Lost Tolerance in Autoimmunity

Monday, February 22 | 8:00AM - 11:00AM
Signaling Negative Selection of Autoreactive Lymphocytes
Room: Bataan

Speaker 5 of 5
Maria A. Gutierrez, University of Texas Southwestern Medical Center, USA
Short Talk: Separate Checkpoints Regulate Plasma Cell Accumulation and IgG Autoantibody Production in Lyn-/- Mice

Monday, February 22 | 9:20AM - 9:40AM
Coffee Break
Room: Rio Grande B,C


Monday, February 22 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Monday, February 22 | 11:00AM - 1:00PM
Poster Setup
Room: Rio Grande A,B,C


Monday, February 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Rio Grande A,B,C


Monday, February 22 | 2:30PM - 4:30PM
Workshop 1
Room: Bataan

Speaker 1 of 8
* Kristin V. Tarbell, Amgen, USA

Monday, February 22 | 2:30PM - 4:30PM
Workshop 1
Room: Bataan

Speaker 2 of 8
* Zhibin Chen, University of Miami, USA

Monday, February 22 | 2:30PM - 4:30PM
Workshop 1
Room: Bataan

Speaker 3 of 8
Hsin-Jung Joyce Wu, University of Arizona, USA
Gut-Residing Segmented Filamentous Bacteria can Trigger Autoimmune Arthritis via T Helper 17 Cells

Monday, February 22 | 2:30PM - 4:30PM
Workshop 1
Room: Bataan

Speaker 4 of 8
Yong Fan, University of Pittsburgh, Children's Hospital of Pittsburgh, USA
Autoimmune Diabetes Induced by Thymic Medullary Epithelium-Specific Deletion of Insulin

Monday, February 22 | 2:30PM - 4:30PM
Workshop 1
Room: Bataan

Speaker 5 of 8
Brandy Lynn Houser, Harvard University, USA
Two Distinct Subsets of Macrophages at the Human Maternal-Fetal Interface: Neither Proinflammatory nor Immunosuppressive

Monday, February 22 | 2:30PM - 4:30PM
Workshop 1
Room: Bataan

Speaker 6 of 8
Siamak Jabbarzadeh Tabrizi, Kyushu University, Japan
BCR Signaling Regulates the Expression of IRAK Proteins in Human B Cell Subsets

Monday, February 22 | 2:30PM - 4:30PM
Workshop 1
Room: Bataan

Speaker 7 of 8
Scott M. Lieberman, Children's Hospital of Philadelphia, USA
Characterizing Natural CD4+Foxp3+ Regulatory T Cells by Anatomical Location

Monday, February 22 | 2:30PM - 4:30PM
Workshop 1
Room: Bataan

Speaker 8 of 8
Heather Niederer, University of Cambridge, UK
Copy Number, Linkage Disequilibrium and Disease Association in the FCGR Locus

Monday, February 22 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, February 22 | 5:00PM - 7:00PM
Early Moments in Autoimmunity
Room: Bataan

Speaker 1 of 4
Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Tolerogenic and Immunogenic DCs

Monday, February 22 | 5:00PM - 7:00PM
Early Moments in Autoimmunity
Room: Bataan

Speaker 2 of 4
* Teresa P. DiLorenzo, Albert Einstein College of Medicine, USA
Autoimmunity and Tolerance in Type 1 Diabetes

Monday, February 22 | 5:00PM - 7:00PM
Early Moments in Autoimmunity
Room: Bataan

Speaker 3 of 4
Partha S. Biswas, University of Pittsburgh, USA
Short Talk: ROCK2 and IRF4: A Novel Interaction Regulating IL-17 and IL-21 Production and the Development of Autoimmunity

Monday, February 22 | 5:00PM - 7:00PM
Early Moments in Autoimmunity
Room: Bataan

Speaker 4 of 4
Lars Rönnblom, Uppsala Universitet, Sweden
Controls of the Unfolding of Lupus

Monday, February 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Rio Grande A,B,C


Monday, February 22 | 7:30PM - 10:00PM
Poster Session 1
Room: Rio Grande A,B,C


Tuesday, February 23 | 7:00AM - 8:00AM
Breakfast
Room: Rio Grande B,C,D


Tuesday, February 23 | 8:00AM - 11:00AM
B Cell Effectors and Regulators
Room: Bataan

Speaker 1 of 5
Robert Brink, Garvan Institute of Medical Research, Australia
Early B cell differentiation and the germinal centre response

Tuesday, February 23 | 8:00AM - 11:00AM
B Cell Effectors and Regulators
Room: Bataan

Speaker 2 of 5
* Betty Diamond, Feinstein Institute for Medical Research, USA
Regulation of GC-matured B cells

Tuesday, February 23 | 8:00AM - 11:00AM
B Cell Effectors and Regulators
Room: Bataan

Speaker 3 of 5
Claudia Mauri, University College London, UK
Regulatory B Cells in Health and in Patients with SLE

Tuesday, February 23 | 8:00AM - 11:00AM
B Cell Effectors and Regulators
Room: Bataan

Speaker 4 of 5
Gregg J. Silverman, New York University Langone Medical Center, USA
Regulatory Natural Antibodies Control Inflammatory Responses and Protect From Autoimmune Disease

Tuesday, February 23 | 8:00AM - 11:00AM
B Cell Effectors and Regulators
Room: Bataan

Speaker 5 of 5
Tomabu G. Adjobimey, Institute for Medical Immunology Microbiology and Parasitology, Germany
Short Talk: Regulatory T Cells Induce IgG4 Production by B Cells through GITR/GITR-L Interaction, IL-10 and TGF-beta

Tuesday, February 23 | 9:20AM - 9:40AM
Coffee Break
Room: Rio Grande B,C


Tuesday, February 23 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Tuesday, February 23 | 11:00AM - 1:00PM
Poster Setup
Room: Rio Grande A,B,C


Tuesday, February 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Rio Grande A,B,C


Tuesday, February 23 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, February 23 | 5:00PM - 7:00PM
Braking Autoimmunity
Room: Bataan

Speaker 1 of 4
* Diane Mathis, Harvard Medical School, USA
Molecular Pathways Controlling Autoimmunity

Tuesday, February 23 | 5:00PM - 7:00PM
Braking Autoimmunity
Room: Bataan

Speaker 2 of 4
Shohei Hori, RIKEN Research Center for Allergy and Immunology, Japan
Stability and Plasticity in Regulatory T Cell Differentiation

Tuesday, February 23 | 5:00PM - 7:00PM
Braking Autoimmunity
Room: Bataan

Speaker 3 of 4
Juan J. Lafaille, New York University School of Medicine, USA
Anergy and Tolerance

Tuesday, February 23 | 5:00PM - 7:00PM
Braking Autoimmunity
Room: Bataan

Speaker 4 of 4
Anneleen Bosma, University College London, UK
Short Talk: Lipid Antigen Presentation by B Cells is Important to Trigger iNKT Cell Expansion for Mediation of an Anti-Inflammatory Response

Tuesday, February 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Rio Grande A,B,C


Tuesday, February 23 | 7:30PM - 10:00PM
Poster Session 2
Room: Rio Grande A,B,C


Wednesday, February 24 | 7:00AM - 8:00AM
Breakfast
Room: Rio Grande B,C,D


Wednesday, February 24 | 8:00AM - 11:00AM
Regulating Thresholds for Activation and Tolerance I
Room: Bataan

Speaker 1 of 4
Bruce Compton Richardson, University of Michigan, USA
Chromatin Structure and Immune Activation in Autoimmunity

Wednesday, February 24 | 8:00AM - 11:00AM
Regulating Thresholds for Activation and Tolerance I
Room: Bataan

Speaker 2 of 4
Ian R. Rifkin, Boston University, USA
Toll-like Receptor Signaling Pathways and Lupus Pathogenesis

Wednesday, February 24 | 8:00AM - 11:00AM
Regulating Thresholds for Activation and Tolerance I
Room: Bataan

Speaker 3 of 4
Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
The Adipocyte and the Monocyte

Wednesday, February 24 | 8:00AM - 11:00AM
Regulating Thresholds for Activation and Tolerance I
Room: Bataan

Speaker 4 of 4
* Jeffrey V. Ravetch, Rockefeller University, USA
The Up- and Down-Side of Immune Complexes

Wednesday, February 24 | 9:20AM - 9:40AM
Coffee Break
Room: Rio Grande B,C


Wednesday, February 24 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, February 24 | 11:15AM - 1:00PM
Poster Setup
Room: Rio Grande A,B,C


Wednesday, February 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Rio Grande A,B,C


Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2
Room: Bataan

Speaker 1 of 7
* Alessandra Pernis, Weill Cornell Medicine, USA

Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2
Room: Bataan

Speaker 2 of 7
* William M. Ridgway, University of Cincinnati College of Medicine, USA

Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2
Room: Bataan

Speaker 3 of 7
Donald M. Simons, AbbVie Bioresearch Center, USA
Inflammatory Monocytes from Arthritic Mice Induce Th17 Cell Differentiation

Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2
Room: Bataan

Speaker 4 of 7
Reiko Takahashi, Keio University School of Medicine, Japan
SOCS1 Mediates Stabilization of Foxp3 Expression in Treg Cells

Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2
Room: Bataan

Speaker 5 of 7
Charis E. Teh, John Curtin School of Medical Research, Australia
Combinatorial Defects in Central and Peripheral Tolerance Checkpoints Precipitate Autoimmune Pancreatitis and Sialadenitis

Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2
Room: Bataan

Speaker 6 of 7
Falk Weih, Leibniz-Institute for Age Research, Germany
Role of RelA and RelB in Medullary Thymic Epithelial Cells in the Establishment of Immunological Self-Tolerance

Wednesday, February 24 | 2:30PM - 4:30PM
Workshop 2
Room: Bataan

Speaker 7 of 7
Duane R. Wesemann, Harvard Medical School, USA
Peripheral B Cell Receptor Editing

Wednesday, February 24 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, February 24 | 5:00PM - 7:00PM
Tissue Response: Turning the Other Cheek (Or Not)
Room: Bataan

Speaker 1 of 4
Bryce A. Binstadt, University of Minnesota, USA
Effector Pathways in Multi-Organ Autoimmunity

Wednesday, February 24 | 5:00PM - 7:00PM
Tissue Response: Turning the Other Cheek (Or Not)
Room: Bataan

Speaker 2 of 4
Matthias Kretzler, University of Michigan, USA
A Systems View of Regulatory Networks in Lupus Nephritis

Wednesday, February 24 | 5:00PM - 7:00PM
Tissue Response: Turning the Other Cheek (Or Not)
Room: Bataan

Speaker 3 of 4
* William M. Ridgway, University of Cincinnati College of Medicine, USA
Why Some Tissues are Targeted for Damage

Wednesday, February 24 | 5:00PM - 7:00PM
Tissue Response: Turning the Other Cheek (Or Not)
Room: Bataan

Speaker 4 of 4
Javier Ochoa-Repáraz, Eastern Washington University, USA
Short Talk: Oral Treatment with Purified Polysaccharide A (PSA) of Human Commensal Bacteroides Fragilis Protects Against Experimental CNS Demyelinating Disease

Wednesday, February 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Rio Grande A,B,C


Wednesday, February 24 | 7:30PM - 10:00PM
Poster Session 3
Room: Rio Grande A,B,C


Thursday, February 25 | 7:00AM - 8:00AM
Breakfast
Room: Rio Grande B,C,D


Thursday, February 25 | 8:00AM - 11:00AM
Regulating Thresholds for Activation and Tolerance II
Room: Bataan

Speaker 1 of 5
Charlotte Cunningham-Rundles, Mount Sinai Medical Center, USA
Immunodeficiency and Autoimmunity in Man

Thursday, February 25 | 8:00AM - 11:00AM
Regulating Thresholds for Activation and Tolerance II
Room: Bataan

Speaker 2 of 5
Roberta Pelanda, University of Colorado Denver, USA
Antigen and BAFF Receptors Guide the Selection and Differentiation of Immature B Cells

Thursday, February 25 | 8:00AM - 11:00AM
Regulating Thresholds for Activation and Tolerance II
Room: Bataan

Speaker 3 of 5
* Carola G. Vinuesa, Australian National University, Australia
T Follicular Helper Cells in the Control of Autoimmune Disease

Thursday, February 25 | 8:00AM - 11:00AM
Regulating Thresholds for Activation and Tolerance II
Room: Bataan

Speaker 4 of 5
Jarish N. Cohen, University of Virginia Health Systems, USA
Short Talk: Lymphatic Endothelial Cells Mediate CD8+ T Cell Peripheral Tolerance by Direct Antigen Presentation that is Independent of Aire

Thursday, February 25 | 8:00AM - 11:00AM
Regulating Thresholds for Activation and Tolerance II
Room: Bataan

Speaker 5 of 5
Norihito Kawasaki, The Scripps Research Institute, USA
Short Talk: CD22 is a Potent Negative Regulator of TLRs in B Cells

Thursday, February 25 | 9:20AM - 9:40AM
Coffee Break
Room: Rio Grande B,C


Thursday, February 25 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Thursday, February 25 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, February 25 | 5:00PM - 7:00PM
Novel Insights and Novel Therapeutics
Room: Bataan

Speaker 1 of 3
Antonio Uccelli, Azienda Ospedaliera Universitaria San Martino di Genova, Italy
Mesenchymal Stem Cells: A New Cell Therapy for Autoimmune Diseases

Thursday, February 25 | 5:00PM - 7:00PM
Novel Insights and Novel Therapeutics
Room: Bataan

Speaker 2 of 3
* Kevin J. Tracey, Feinstein Institute for Medical Research, USA
Reflexive Control of Autoinflammation and Immunity

Thursday, February 25 | 5:00PM - 7:00PM
Novel Insights and Novel Therapeutics
Room: Bataan

Speaker 3 of 3
Marijke Niens, The Jackson Laboratory, USA
Short Talk: Prevention of Type 1 Diabetes in “HLA Humanized” NOD Mice by a Multi-Peptide Coupled-Cell Approach

Thursday, February 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Rio Grande A,B,C


Thursday, February 25 | 8:00PM - 11:00PM
Entertainment
Room: Rio Grande


Thursday, February 25 | 8:00PM - 11:00PM
Cash Bar
Room: Rio Grande


Friday, February 26 | 10:25AM - 10:25AM
Departure


*Session Chair.