Web Desc
Lymphocyte Activation and Gene Expression
Organizer(s): Leslie J. Berg, Lawrence E. Samelson and Facundo D. Batista
Date: February 27 - March 04, 2010
Location: Beaver Run Resort, Breckenridge, CO, USA
Sponsored by Amgen Inc., Genzyme Corporation and Novo Nordisk A/S
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Summary of Meeting:
Lymphocytes mediate the adaptive immune responses to antigens derived from infectious agents, transformed cells, transplanted organs and, in the setting of autoimmunity, ones own cells. The study of lymphocyte activation and gene expression is central to understanding the complex biology of these cells and offers hope for regulating these cells in different clinical settings. Much has been learned in the past several decades in this field. Receptors, enzymes and adapter molecules have been identified, signaling cascades and networks have been defined, and the complex regulation of gene expression has been explored. Nonetheless many basic questions remain to be elucidated. Among several contentious areas of research that will be presented by experts at this meeting are the actual means by which antigen receptors initiate the activation process, how activation induces changes in signaling pathways, intracellular organelles and the cytoskeleton, and how changes in chromatin and transcriptional factors determine gene expression.
Scholarship Deadline: October 27 2009
Discounted Abstract Deadline: October 27 2009
Abstract Deadline: November 30 2009
Discounted Registration Deadline: December 28 2009
We gratefully acknowledge additional support for this conference from:
Educational donation provided by AmgenGenzyme CorporationInvitrogen CorporationJDRFNovo Nordisk A/SRigel Pharmaceuticals, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI085592-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, February 27 | 6:30AM - 7:30AM
Refreshments
Room: Foyer


Saturday, February 27 | 3:00PM - 7:30PM
Registration
Room: Foyer


Saturday, February 27 | 7:30PM - 8:30PM
Keynote Address: The TCR
Room: Peak 5

Speaker 1 of 2
* Lawrence E. Samelson, National Institutes of Health, USA

Saturday, February 27 | 7:30PM - 8:30PM
Keynote Address: The TCR
Room: Peak 5

Speaker 2 of 2
Mark M. Davis, Stanford University School of Medicine, USA
T-Cell Receptor Signaling

Sunday, February 28 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Sunday, February 28 | 8:00AM - 11:15AM
Initiation of Antigen Receptor Signaling
Room: Peak 5

Speaker 1 of 6
* Susan K. Pierce, NIAID, National Institutes of Health, USA
The Molecular Mechanisms Underlying the Initiation of BCR Signaling

Sunday, February 28 | 8:00AM - 11:15AM
Initiation of Antigen Receptor Signaling
Room: Peak 5

Speaker 2 of 6
Phillip Anton van der Merwe, University of Oxford, UK
Molecular Mechanism of TCR Triggering

Sunday, February 28 | 8:00AM - 11:15AM
Initiation of Antigen Receptor Signaling
Room: Peak 5

Speaker 3 of 6
Balbino Alarcón, CSIC-Universidad Autonoma de Madrid, Spain
Intramolecular Mechanism for Transmission of the Conformational Change in the TCR

Sunday, February 28 | 8:00AM - 11:15AM
Initiation of Antigen Receptor Signaling
Room: Peak 5

Speaker 4 of 6
Arup K. Chakraborty, Massachusetts Institute of Technology, USA
How T Cells “See” Antigen

Sunday, February 28 | 8:00AM - 11:15AM
Initiation of Antigen Receptor Signaling
Room: Peak 5

Speaker 5 of 6
Nina G. Caculitan, Genentech, Inc., USA
Short Talk: The Regulation of Protein Spatial Sorting and its Effect on T Cell Signaling in the Immunological Synapse

Sunday, February 28 | 8:00AM - 11:15AM
Initiation of Antigen Receptor Signaling
Room: Peak 5

Speaker 6 of 6
Mira Barda-Saad, Bar Ilan University, Israel
Short Talk: THE NEGATIVE REGULATION MECHANISM OF THE
WISKOTT-ALDRICH SYNDROME PROTEIN


Sunday, February 28 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Sunday, February 28 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Sunday, February 28 | 11:15AM - 1:00PM
Poster Setup
Room: Peaks 1-4


Sunday, February 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-4


Sunday, February 28 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Sunday, February 28 | 5:00PM - 7:00PM
Cell Biology of Lymphocyte Activation
Room: Peak 5

Speaker 1 of 4
Facundo D. Batista, Massachusetts Institute of Technology and Harvard University, USA
Interplay between the BCR and Cytoskeleton: A Mechanism to Regulate Lymphocyte Activation and Tonic Signaling?

Sunday, February 28 | 5:00PM - 7:00PM
Cell Biology of Lymphocyte Activation
Room: Peak 5

Speaker 2 of 4
* Gillian Griffiths, Cambridge Institute for Medical Research, UK
The Immunological Synapse: A Focal Point for Exocytosis and Endocytosis

Sunday, February 28 | 5:00PM - 7:00PM
Cell Biology of Lymphocyte Activation
Room: Peak 5

Speaker 3 of 4
Matthew F. Krummel, University of California, San Francisco, USA
The Interplay of T Motility and Signaling

Sunday, February 28 | 5:00PM - 7:00PM
Cell Biology of Lymphocyte Activation
Room: Peak 5

Speaker 4 of 4
Sarah Russell, Swinburne University of Technology, Australia
Short Talk: Orchestratation of Lymphocyte Fate by the Polarity Network

Sunday, February 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-4


Sunday, February 28 | 7:30PM - 10:00PM
Poster Session 1
Room: Peaks 1-4


Monday, March 01 | 7:00AM - 8:00AM
Poster Setup
Room: Peaks 1-4


Monday, March 01 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Monday, March 01 | 8:00AM - 11:15AM
Transcriptional Regulation and Chromatin Remodeling during L
ymphocyte Activation

Room: Peak 5

Speaker 1 of 6
* Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Ca Signaling and Transcription Regulation in Lymphocytes

Monday, March 01 | 8:00AM - 11:15AM
Transcriptional Regulation and Chromatin Remodeling during L
ymphocyte Activation

Room: Peak 5

Speaker 2 of 6
Steven L. Reiner, Columbia University, USA
Specifying the T Cell Fates Required for Immunity

Monday, March 01 | 8:00AM - 11:15AM
Transcriptional Regulation and Chromatin Remodeling during L
ymphocyte Activation

Room: Peak 5

Speaker 3 of 6
Joonsoo Kang, University of Massachusetts Medical School, USA
Transcriptional Regulation of alpha-beta vs. gamma-delta T Cell Lineage Commitment

Monday, March 01 | 8:00AM - 11:15AM
Transcriptional Regulation and Chromatin Remodeling during L
ymphocyte Activation

Room: Peak 5

Speaker 4 of 6
Casey T. Weaver, University of Alabama at Birmingham, USA
Gene Expression and the TH17 Response

Monday, March 01 | 8:00AM - 11:15AM
Transcriptional Regulation and Chromatin Remodeling during L
ymphocyte Activation

Room: Peak 5

Speaker 5 of 6
Michael J. Pazin, NHGRI, National Institutes of Health, USA
Short Talk: The Chromatin Remodeling Landscape of T Helper Cell Differentiation

Monday, March 01 | 8:00AM - 11:15AM
Transcriptional Regulation and Chromatin Remodeling during L
ymphocyte Activation

Room: Peak 5

Speaker 6 of 6
Robert J. Johnston, Bristol-Myers Squibb, USA
Short Talk: Bcl6 and Blimp-1 are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

Monday, March 01 | 8:00AM - 5:00PM
Poster Viewing
Room: Peaks 1-4


Monday, March 01 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Monday, March 01 | 11:30AM - 12:30PM
Lunch


Monday, March 01 | 12:30PM - 2:30PM
Poster Session 2
Room: Peaks 1-4


Monday, March 01 | 2:30PM - 4:30PM
Workshop 1: Early Events in Lymphocyte Activation
Room: Peak 5

Speaker 1 of 9
* Arthur Weiss, University of California, San Francisco, USA

Monday, March 01 | 2:30PM - 4:30PM
Workshop 1: Early Events in Lymphocyte Activation
Room: Peak 5

Speaker 2 of 9
Melania Capasso, Barts Cancer Institute, UK
Control of B Cell Activation and Metabolism by the Voltage-Gated Proton Channel HVCN1

Monday, March 01 | 2:30PM - 4:30PM
Workshop 1: Early Events in Lymphocyte Activation
Room: Peak 5

Speaker 3 of 9
Olga Anna Ksionda, University of California, San Francisco, USA
The Role of the Localization of Vav1 during T Cell Activation

Monday, March 01 | 2:30PM - 4:30PM
Workshop 1: Early Events in Lymphocyte Activation
Room: Peak 5

Speaker 4 of 9
Aaron J. Marshall, University of Manitoba, Canada
The Phosphoinositide 3-Kinase Effector Molecule Bam32/DAPP1 Promotes B Cell Adhesion and Formation of Polarized Conjugates with T Cells

Monday, March 01 | 2:30PM - 4:30PM
Workshop 1: Early Events in Lymphocyte Activation
Room: Peak 5

Speaker 5 of 9
David Oh, Stanford University, USA
Ca2+ Signaling and the Regulation of Thymocyte Mobility during Negative Selection in Thymic Slices

Monday, March 01 | 2:30PM - 4:30PM
Workshop 1: Early Events in Lymphocyte Activation
Room: Peak 5

Speaker 6 of 9
Hanne L. Ostergaard, University of Alberta, Canada
Regulation of the Tyrosine Kinase Pyk2 By Calcium in Cytotoxic T Lymphocytes

Monday, March 01 | 2:30PM - 4:30PM
Workshop 1: Early Events in Lymphocyte Activation
Room: Peak 5

Speaker 7 of 9
Bruno Silva-Santos, University of Lisbon, Portugal
Differential Requirements on TCR/ CD27 versus TLR Signaling for Activation of Discrete Pro-Inflammatory gamma-delta T Cell Subsets

Monday, March 01 | 2:30PM - 4:30PM
Workshop 1: Early Events in Lymphocyte Activation
Room: Peak 5

Speaker 8 of 9
Neetu Gupta, Cleveland Clinic, USA
Regulation of Antigen-Dependent B Cell Activation by Tyrosine and Threonine Phosphorylation of the ERM Family Protein Ezrin

Monday, March 01 | 2:30PM - 4:30PM
Workshop 1: Early Events in Lymphocyte Activation
Room: Peak 5

Speaker 9 of 9
Steve R. Roffler, Academia Sinica, Taiwan
Mechanical Forces Acting on the T Cell Receptor Complex Can Trigger TCR Signaling

Monday, March 01 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, March 01 | 5:00PM - 7:00PM
Downstream Pathways of Antigen Receptor Signaling I
Room: Peak 5

Speaker 1 of 6
* Doreen A. Cantrell, University of Dundee, UK
The Function of Protein Kinase B/Akt in Peripheral T Cells

Monday, March 01 | 5:00PM - 7:00PM
Downstream Pathways of Antigen Receptor Signaling I
Room: Peak 5

Speaker 2 of 6
Pamela L. Schwartzberg, NIAID, NHGRI, National Institutes of Health, USA
Altered T Cell Function in Mice Deficient in SAP, a Model for X-Linked Lymphoproliferative Disease

Monday, March 01 | 5:00PM - 7:00PM
Downstream Pathways of Antigen Receptor Signaling I
Room: Peak 5

Speaker 3 of 6
Bernard Malissen, Centre d'Immunologie de Marseille-Luminy, France
Th2 Lymphoproliferative Disorders Resulting from Defective LAT Signalosomes

Monday, March 01 | 5:00PM - 7:00PM
Downstream Pathways of Antigen Receptor Signaling I
Room: Peak 5

Speaker 4 of 6
Debbie A. Yablonski, Technion - Israel Institute of Technology, Israel
Short Talk: Regulatory Interactions within the SLP-76-Nucleated Complex

Monday, March 01 | 5:00PM - 7:00PM
Downstream Pathways of Antigen Receptor Signaling I
Room: Peak 5

Speaker 5 of 6
Michelle Krogsgaard, New York University School of Medicine, USA
Short Talk:

Monday, March 01 | 5:00PM - 7:00PM
Downstream Pathways of Antigen Receptor Signaling I
Room: Peak 5

Speaker 6 of 6
Morgan Huse, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Probing Inhibitory Signaling Dynamics in NK Cells by Photostimulation

Monday, March 01 | 7:00PM - 7:00PM
On Own for Dinner
Room: Peaks 1-4


Tuesday, March 02 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Tuesday, March 02 | 8:00AM - 11:15AM
Downstream Pathways of Antigen Receptor Signaling II
Room: Peak 5

Speaker 1 of 6
Arthur Weiss, University of California, San Francisco, USA
Turning T Cells Off and On with Small Molecule Inhibitors of Tyrosine Kinases

Tuesday, March 02 | 8:00AM - 11:15AM
Downstream Pathways of Antigen Receptor Signaling II
Room: Peak 5

Speaker 2 of 6
Andrey S. Shaw, Genentech, Inc., USA
Imaging T Cell Activation

Tuesday, March 02 | 8:00AM - 11:15AM
Downstream Pathways of Antigen Receptor Signaling II
Room: Peak 5

Speaker 3 of 6
Jürgen Wienands, Georg August University of Goettingen, Germany
Short Talk: Composition and Dynamic Assembly of B Cell Signalosomes as Revealed by Functional Proteomics

Tuesday, March 02 | 8:00AM - 11:15AM
Downstream Pathways of Antigen Receptor Signaling II
Room: Peak 5

Speaker 4 of 6
* Gary A. Koretzky, University of Pennsylvania School of Medicine, USA
Role of SLP-76 in Immune Cell Development and Function

Tuesday, March 02 | 8:00AM - 11:15AM
Downstream Pathways of Antigen Receptor Signaling II
Room: Peak 5

Speaker 5 of 6
Bridget S. Wilson, University of New Mexico Health Science Center, USA
High Resolution Imaging of Fc[epislon]RI Organization and Receptor Dynamics: Immobilization is not a Requirement for Signal Initiation

Tuesday, March 02 | 8:00AM - 11:15AM
Downstream Pathways of Antigen Receptor Signaling II
Room: Peak 5

Speaker 6 of 6
Stephen C. Bunnell, Tufts University School of Medicine, USA
Short Talk: VLA-4 Inhibits the Centralization of SLP-76 Microclusters by Resisting the Contraction of Myosin IIA Filaments

Tuesday, March 02 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, March 02 | 11:15AM - 1:00PM
Poster Setup
Room: Peaks 1-4


Tuesday, March 02 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, March 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-4


Tuesday, March 02 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, March 02 | 5:00PM - 7:00PM
Downstream Pathways of Antigen Receptor Signaling III
Room: Peak 5

Speaker 1 of 4
* Leslie J. Berg, University of Massachusetts Medical Center, USA
Tec Kinases in T Cell Differentiation

Tuesday, March 02 | 5:00PM - 7:00PM
Downstream Pathways of Antigen Receptor Signaling III
Room: Peak 5

Speaker 2 of 4
Lawrence E. Samelson, National Institutes of Health, USA
Signaling at the TCR

Tuesday, March 02 | 5:00PM - 7:00PM
Downstream Pathways of Antigen Receptor Signaling III
Room: Peak 5

Speaker 3 of 4
Richard S. Lewis, Stanford University School of Medicine, USA
Molecular Mechanisms for Activation and Inactivation of Calcium Channels in T Cells

Tuesday, March 02 | 5:00PM - 7:00PM
Downstream Pathways of Antigen Receptor Signaling III
Room: Peak 5

Speaker 4 of 4
Patrick G. Hogan, La Jolla Institute of Allergy and Immunology, USA
Short Talk: Minimal Requirement for Store-Operated Calcium Entry: STIM1 Gates ORAI1 Channels in vitro

Tuesday, March 02 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-4


Tuesday, March 02 | 7:30PM - 10:00PM
Poster Session 3
Room: Peaks 1-4


Wednesday, March 03 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Wednesday, March 03 | 8:00AM - 11:15AM
Visualization of Lymphocyte Activation
Room: Peak 5

Speaker 1 of 6
* Ellen A. Robey, University of California, Berkeley, USA
Visualizing Thymic Selection in situ

Wednesday, March 03 | 8:00AM - 11:15AM
Visualization of Lymphocyte Activation
Room: Peak 5

Speaker 2 of 6
Michael L. Dustin, University of Oxford, UK
Immunological Synapse Formation in Normal and Pathological Immune Responses

Wednesday, March 03 | 8:00AM - 11:15AM
Visualization of Lymphocyte Activation
Room: Peak 5

Speaker 3 of 6
Ronald N. Germain, NIAID, National Institutes of Health, USA
Cell Dynamics during the Initiation and Effector Phases of Adaptive Immune Responses

Wednesday, March 03 | 8:00AM - 11:15AM
Visualization of Lymphocyte Activation
Room: Peak 5

Speaker 4 of 6
Takashi Saito, RIKEN Center for Allergy and Immunology, Japan
Molecular Dynamics for T-Cell Activation and Co-stimulation

Wednesday, March 03 | 8:00AM - 11:15AM
Visualization of Lymphocyte Activation
Room: Peak 5

Speaker 5 of 6
Daniel M. Davis, Imperial College London, UK
Short Talk: Membrane Nanotubes Support Sub-Micron Scale Immune Synapses and Aid Cytolysis of Distant Target Cells

Wednesday, March 03 | 8:00AM - 11:15AM
Visualization of Lymphocyte Activation
Room: Peak 5

Speaker 6 of 6
Philippe Bousso, Institute Pasteur, France
Short Talk: Intravital Imaging Reveals Distinct Dynamics of NK Cells and CD8+ T Cells during Effector Function in Solid Tumors

Wednesday, March 03 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, March 03 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, March 03 | 2:30PM - 4:30PM
Workshop 2: Late Events in Lymphocyte Activation
Room: Peak 5

Speaker 1 of 9
* Pamela L. Schwartzberg, NIAID, NHGRI, National Institutes of Health, USA

Wednesday, March 03 | 2:30PM - 4:30PM
Workshop 2: Late Events in Lymphocyte Activation
Room: Peak 5

Speaker 2 of 9
Mark R. Boothby, Vanderbilt University Medical Center, USA
Stage-Specific Essential Roles of Rictor, a Mammalian Target of Rapamycin Complex 2 (mTORC2) Subunit, in T Cell Differentiation Define a Bifurcation in the Signal Relay

Wednesday, March 03 | 2:30PM - 4:30PM
Workshop 2: Late Events in Lymphocyte Activation
Room: Peak 5

Speaker 3 of 9
Jennifer L. Cannons, National Institutes of Health, USA
A Multi-Stage T:B Lymphocyte Adhesion Process is Required for Germinal Centre Responses

Wednesday, March 03 | 2:30PM - 4:30PM
Workshop 2: Late Events in Lymphocyte Activation
Room: Peak 5

Speaker 4 of 9
Greg M. Delgoffe, University of Pittsburgh, USA
The mTOR Signaling Complexes TORC1 and TORC2 Selectively Regulate CD4+ T Cell Differentiation

Wednesday, March 03 | 2:30PM - 4:30PM
Workshop 2: Late Events in Lymphocyte Activation
Room: Peak 5

Speaker 5 of 9
Guo Fu, Xiamen University, China
Themis Regulates Thymocyte Signaling

Wednesday, March 03 | 2:30PM - 4:30PM
Workshop 2: Late Events in Lymphocyte Activation
Room: Peak 5

Speaker 6 of 9
Katrina L. Randall, Canberra Hospital, Australia
DOCK8 Mutations Cripple B Cell Immune Synapse Formation, Germinal Centers and Long-Lived Antibody Production

Wednesday, March 03 | 2:30PM - 4:30PM
Workshop 2: Late Events in Lymphocyte Activation
Room: Peak 5

Speaker 7 of 9
Yuri K. Sykulev, Thomas Jefferson University, USA
Kinetics of Early TCR Signaling Influences the Path of Granule Delivery by CTL

Wednesday, March 03 | 2:30PM - 4:30PM
Workshop 2: Late Events in Lymphocyte Activation
Room: Peak 5

Speaker 8 of 9
Bazarragchaa Damdinsuren, National Institute on Aging, National Institutes of Health, USA
Single-Round of Antigen Receptor Signaling Programs Naive B Cells to Receive T Cell Help

Wednesday, March 03 | 2:30PM - 4:30PM
Workshop 2: Late Events in Lymphocyte Activation
Room: Peak 5

Speaker 9 of 9
Vanessa Marie Hubbard-Lucey, New York University School of Medicine, USA
Macroautophagy Regulates CD4+ T Cell Function

Wednesday, March 03 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, March 03 | 5:00PM - 7:00PM
Regulation of the Immune Response by microRNA
Room: Peak 5
Session supported in part by the Juvenile Diabetes Research Foundation
Speaker 1 of 4
* Matthias Merkenschlager, Imperial College London, UK
Cohesins and Gene Expression: From Proof-of-Principle Towards Cell Lineage- and Developmental Stage-Specific Regulation

Wednesday, March 03 | 5:00PM - 7:00PM
Regulation of the Immune Response by microRNA
Room: Peak 5
Session supported in part by the Juvenile Diabetes Research Foundation
Speaker 2 of 4
Carola G. Vinuesa, Australian National University, Australia
Role of Bcl-6 in Specializing the Function of T Follicular Helper Cells

Wednesday, March 03 | 5:00PM - 7:00PM
Regulation of the Immune Response by microRNA
Room: Peak 5
Session supported in part by the Juvenile Diabetes Research Foundation
Speaker 3 of 4
Li-Fan Lu, University of California, San Diego, USA
Short Talk: Function of miR-146a in Controlling Treg Cell-Mediated Regulation of TH1 Responses

Wednesday, March 03 | 5:00PM - 7:00PM
Regulation of the Immune Response by microRNA
Room: Peak 5
Session supported in part by the Juvenile Diabetes Research Foundation
Speaker 4 of 4
Anna Barbara Stittrich, German Arthritis Research Center, Germany
Short Talk: MicroRNA-182 Promotes Clonal Expansion of Activated T Helper Cells

Wednesday, March 03 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-4


Wednesday, March 03 | 8:00PM - 11:00PM
Entertainment
Room: Peaks 1-4


Wednesday, March 03 | 8:00PM - 11:00PM
Cash Bar
Room: Peaks 1-4


Thursday, March 04 | 10:22AM - 10:22AM
Departure


*Session Chair
†Invited, not yet responded.