Web Desc
Biomolecular Interaction Networks: Function and Disease
Organizer(s): Anna Panchenko, Teresa Przytycka and Andrea Califano
Date: March 07 - 12, 2010
Location: Fairmont Le Château Frontenac, Québec, QC, Canada
Supported by The Directors' Fund
Summary of Meeting:
The aim of this symposium is to bring together researchers from different fields of computational and experimental biology, to discuss the use of biomolecular interaction networks to study cell function in both physiological and pathological contexts. These interaction maps, also known as interactomes, model protein-protein, protein-DNA and protein-small molecule interaction networks either within an organism or within specific cellular contexts. The function of proteins, nucleic acids, and other biomolecules can only be defined through their interactions in vivo. Such biochemical interactions – including those involved in signal transduction, transcriptional and translational regulation, as well as in the assembly of large molecular complexes – are astonishing in their magnitude and diversity. For instance, it has been shown that most proteins interact with multiple partners, forming intricate interaction networks. Similarly, individual transcription factor can bind to tens of thousands of genomic sites and regulate the expression of thousands of genes, both in isolation and in combinatorial fashion. Regulatory interactions play a key role in determining cellular differentiation, in maintaining cellular and organism homeostasis, and in triggering abnormal differentiation events leading to human disease including cancer. Not surprisingly, even slight genetic and epigenetic perturbations of these regulatory pathways can trigger macroscopic changes in normal cell physiology and lead to disease. Due to the abundance of experimental data, researchers are starting to uncover some general rules and principles underlying molecular interaction networks: their topological properties, the relationships between their components, evolutionary conservation and divergence, and their role in maintaining specific cellular functions and processes. Despite significant advances, however, knowledge about the distinct functional roles of many proteins is still elusive. Thus, interaction networks have emerged as exceedingly useful tools in predicting context-specific molecular function based on knowledge of upstream regulators, cognate binding partners, and downstream regulated targets. Furthermore, molecular interaction networks are starting to provide a unique integrative context to study additional disease-related genetic and epigenetic data, including single nucleotide mutations and polymorphisms, gene copy number alterations and complex, polygenic diseases.
Scholarship Deadline: November 9 2009
Discounted Abstract Deadline: November 9 2009
Abstract Deadline: December 7 2009
Discounted Registration Deadline: January 7 2010
We gratefully acknowledge additional support for this conference from:
BioMarin Pharmaceutical Inc.


William A. McLaughlin
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Pubget Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA144363-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 07 | 3:00PM - 7:30PM
Registration
Room: Vercheres


Sunday, March 07 | 3:00PM - 7:30PM
Refreshments
Room: Vercheres


Monday, March 08 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac


Monday, March 08 | 8:00AM - 11:15AM
Experimental Identification, Characterization and Verificati
on of Interaction Data

Room: Salle de Bal
This session will describe different experimental techniques of biomolecular interaction identification, will discuss the main promises and pitfalls of different methods and present several approaches to verify and validate the diverse experimental data.
Speaker 1 of 7
* Ruth Nussinov, National Cancer Institute and Tel Aviv University, USA

Monday, March 08 | 8:00AM - 11:15AM
Experimental Identification, Characterization and Verificati
on of Interaction Data

Room: Salle de Bal
This session will describe different experimental techniques of biomolecular interaction identification, will discuss the main promises and pitfalls of different methods and present several approaches to verify and validate the diverse experimental data.
Speaker 2 of 7
Anne-Claude Gavin, European Molecular Biology Laboratory, Germany
Biomolecular Networks from Proteins to Small Molecules

Monday, March 08 | 8:00AM - 11:15AM
Experimental Identification, Characterization and Verificati
on of Interaction Data

Room: Salle de Bal
This session will describe different experimental techniques of biomolecular interaction identification, will discuss the main promises and pitfalls of different methods and present several approaches to verify and validate the diverse experimental data.
Speaker 3 of 7
Nevan J. Krogan, University of California, San Francisco, USA
Functional Insights from Protein-Protein and Genetic Interaction Maps

Monday, March 08 | 8:00AM - 11:15AM
Experimental Identification, Characterization and Verificati
on of Interaction Data

Room: Salle de Bal
This session will describe different experimental techniques of biomolecular interaction identification, will discuss the main promises and pitfalls of different methods and present several approaches to verify and validate the diverse experimental data.
Speaker 4 of 7
Douglas A. Lauffenburger, Massachusetts Institute of Technology, USA
Integrated Experimental and Computational Approaches to Dissect Cell Response to Stimuli

Monday, March 08 | 8:00AM - 11:15AM
Experimental Identification, Characterization and Verificati
on of Interaction Data

Room: Salle de Bal
This session will describe different experimental techniques of biomolecular interaction identification, will discuss the main promises and pitfalls of different methods and present several approaches to verify and validate the diverse experimental data.
Speaker 5 of 7
Aimee Dudley, Institute for Systems Biology, USA
Systems Genetics Approaches to Complex Traits and Non-linear Interactions

Monday, March 08 | 8:00AM - 11:15AM
Experimental Identification, Characterization and Verificati
on of Interaction Data

Room: Salle de Bal
This session will describe different experimental techniques of biomolecular interaction identification, will discuss the main promises and pitfalls of different methods and present several approaches to verify and validate the diverse experimental data.
Speaker 6 of 7
Sebastian Kühner, European Molecular Biology Laboratory - EMBL, Germany
Short Talk: Proteome Organization in a Genome-Reduced Bacterium

Monday, March 08 | 8:00AM - 11:15AM
Experimental Identification, Characterization and Verificati
on of Interaction Data

Room: Salle de Bal
This session will describe different experimental techniques of biomolecular interaction identification, will discuss the main promises and pitfalls of different methods and present several approaches to verify and validate the diverse experimental data.
Speaker 7 of 7
Curtis Huttenhower, Harvard School of Public Health, USA
Short Talk: Computational Methodology for Microbial and Metagenomic Characterization using Large Scale Functional Genomic Data Integration

Monday, March 08 | 9:20AM - 9:40AM
Coffee Break
Room: Salle de Bal Foyer


Monday, March 08 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, March 08 | 11:15AM - 1:00PM
Poster Setup
Room: Salle de Bal


Monday, March 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Salle de Bal


Monday, March 08 | 4:30PM - 5:00PM
Coffee Available
Room: Vercheres


Monday, March 08 | 5:00PM - 7:00PM
Biomolecular Network Architecture and Biological Function of
the Cell

Room: Salle de Bal
This session will focus on the characterization of dynamic and functional properties of regulatory and signaling networks. In particular, speakers will discuss genomic and genetic components of transcriptional networks in yeast and human, with a particular emphasis on the perturbations of regulatory networks leading to disease phenotypes.
Speaker 1 of 5
* Ivan Ovcharenko, National Institutes of Health, USA

Monday, March 08 | 5:00PM - 7:00PM
Biomolecular Network Architecture and Biological Function of
the Cell

Room: Salle de Bal
This session will focus on the characterization of dynamic and functional properties of regulatory and signaling networks. In particular, speakers will discuss genomic and genetic components of transcriptional networks in yeast and human, with a particular emphasis on the perturbations of regulatory networks leading to disease phenotypes.
Speaker 2 of 5
Edward M. Marcotte, University of Texas at Austin, USA
Linking Genes to Traits Using Network-Guided Genetics


Monday, March 08 | 5:00PM - 7:00PM
Biomolecular Network Architecture and Biological Function of
the Cell

Room: Salle de Bal
This session will focus on the characterization of dynamic and functional properties of regulatory and signaling networks. In particular, speakers will discuss genomic and genetic components of transcriptional networks in yeast and human, with a particular emphasis on the perturbations of regulatory networks leading to disease phenotypes.
Speaker 3 of 5
Shoshana Wodak, Hospital for Sick Children, Research Institute, Canada
Modularity of the Transcriptional Regulation of Protein Complexes in Yeast

Monday, March 08 | 5:00PM - 7:00PM
Biomolecular Network Architecture and Biological Function of
the Cell

Room: Salle de Bal
This session will focus on the characterization of dynamic and functional properties of regulatory and signaling networks. In particular, speakers will discuss genomic and genetic components of transcriptional networks in yeast and human, with a particular emphasis on the perturbations of regulatory networks leading to disease phenotypes.
Speaker 4 of 5
Hunter B. Fraser, Stanford University, USA
Widespread Adaptive Evolution of Gene Expression

Monday, March 08 | 5:00PM - 7:00PM
Biomolecular Network Architecture and Biological Function of
the Cell

Room: Salle de Bal
This session will focus on the characterization of dynamic and functional properties of regulatory and signaling networks. In particular, speakers will discuss genomic and genetic components of transcriptional networks in yeast and human, with a particular emphasis on the perturbations of regulatory networks leading to disease phenotypes.
Speaker 5 of 5
Raja Jothi, NIEHS, National Institutes of Health, USA
Short Talk: Genomic Analysis Reveals a Tight Link between Transcription Factor Dynamics and Regulatory Network Architecture

Monday, March 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Salle de Bal Foyer


Monday, March 08 | 7:30PM - 10:00PM
Poster Session 1
Room: Salle de Bal


Tuesday, March 09 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac


Tuesday, March 09 | 8:00AM - 11:15AM
General Principles of Molecular Recognition and Binding Spec
ificity

Room: Salle de Bal
This session will highlight the principles of protein recognition, the properties of interaction interfaces in relation to diseases. In particular, it will highlight the recent analyses on specific sequence and structural features of interaction interfaces and discuss the mechanisms of regulation of protein activity and binding selectivity through conformational selection and intrinsic disorder.
Speaker 1 of 7
* Anna Panchenko, NIM, National Institutes of Health, USA

Tuesday, March 09 | 8:00AM - 11:15AM
General Principles of Molecular Recognition and Binding Spec
ificity

Room: Salle de Bal
This session will highlight the principles of protein recognition, the properties of interaction interfaces in relation to diseases. In particular, it will highlight the recent analyses on specific sequence and structural features of interaction interfaces and discuss the mechanisms of regulation of protein activity and binding selectivity through conformational selection and intrinsic disorder.
Speaker 2 of 7
Ruth Nussinov, National Cancer Institute and Tel Aviv University, USA
Protein-Protein Interactions: What is the Preferred Way for Proteins to Interact?

Tuesday, March 09 | 8:00AM - 11:15AM
General Principles of Molecular Recognition and Binding Spec
ificity

Room: Salle de Bal
This session will highlight the principles of protein recognition, the properties of interaction interfaces in relation to diseases. In particular, it will highlight the recent analyses on specific sequence and structural features of interaction interfaces and discuss the mechanisms of regulation of protein activity and binding selectivity through conformational selection and intrinsic disorder.
Speaker 3 of 7
Barry Honig, Columbia University / HHMI, USA
On the Nature of Protein Fold Space: Extracting Functional Information from Apparently Remote Structural Neighbors

Tuesday, March 09 | 8:00AM - 11:15AM
General Principles of Molecular Recognition and Binding Spec
ificity

Room: Salle de Bal
This session will highlight the principles of protein recognition, the properties of interaction interfaces in relation to diseases. In particular, it will highlight the recent analyses on specific sequence and structural features of interaction interfaces and discuss the mechanisms of regulation of protein activity and binding selectivity through conformational selection and intrinsic disorder.
Speaker 4 of 7
Madan Babu Mohan, MRC Laboratory of Molecular Biology, UK
Intrinsically Unstructured Proteins: Regulation and Disease

Tuesday, March 09 | 8:00AM - 11:15AM
General Principles of Molecular Recognition and Binding Spec
ificity

Room: Salle de Bal
This session will highlight the principles of protein recognition, the properties of interaction interfaces in relation to diseases. In particular, it will highlight the recent analyses on specific sequence and structural features of interaction interfaces and discuss the mechanisms of regulation of protein activity and binding selectivity through conformational selection and intrinsic disorder.
Speaker 5 of 7
Anna Tramontano, University of Rome, La Sapienza, Italy
Antibody Structure Prediction: Implications and Applications

Tuesday, March 09 | 8:00AM - 11:15AM
General Principles of Molecular Recognition and Binding Spec
ificity

Room: Salle de Bal
This session will highlight the principles of protein recognition, the properties of interaction interfaces in relation to diseases. In particular, it will highlight the recent analyses on specific sequence and structural features of interaction interfaces and discuss the mechanisms of regulation of protein activity and binding selectivity through conformational selection and intrinsic disorder.
Speaker 6 of 7
Brian Joughin, Massachusetts Institute of Technology, USA
Short Talk: Examination of the Interpositional Dependence of Kinase Specificity on Substrate Sequence

Tuesday, March 09 | 8:00AM - 11:15AM
General Principles of Molecular Recognition and Binding Spec
ificity

Room: Salle de Bal
This session will highlight the principles of protein recognition, the properties of interaction interfaces in relation to diseases. In particular, it will highlight the recent analyses on specific sequence and structural features of interaction interfaces and discuss the mechanisms of regulation of protein activity and binding selectivity through conformational selection and intrinsic disorder.
Speaker 7 of 7
Maricel G. Kann, University of Maryland Baltimore County, USA
Short Talk: Using Correlated Evolution of Interacting Protein Domains to Predict their Interactions

Tuesday, March 09 | 9:20AM - 9:40AM
Coffee Break
Room: Vercheres


Tuesday, March 09 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, March 09 | 11:15AM - 1:00PM
Poster Setup
Room: Salle de Bal


Tuesday, March 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Salle de Bal


Tuesday, March 09 | 4:30PM - 5:00PM
Coffee Available
Room: Vercheres


Tuesday, March 09 | 5:00PM - 7:00PM
From Molecular Interaction Networks to Function Prediction
Room: Salle de Bal
This session will focus on inferring and characterizing cellular functions and functional moonlighting within the context of different types of interactions, and will underline computational methods to predict protein interactions and protein function.
Speaker 1 of 5
* Edward M. Marcotte, University of Texas at Austin, USA

Tuesday, March 09 | 5:00PM - 7:00PM
From Molecular Interaction Networks to Function Prediction
Room: Salle de Bal
This session will focus on inferring and characterizing cellular functions and functional moonlighting within the context of different types of interactions, and will underline computational methods to predict protein interactions and protein function.
Speaker 2 of 5
Mona Singh, Princeton University, USA
Analyzing and Interrogating Protein Interaction Maps via Network Schemas


Tuesday, March 09 | 5:00PM - 7:00PM
From Molecular Interaction Networks to Function Prediction
Room: Salle de Bal
This session will focus on inferring and characterizing cellular functions and functional moonlighting within the context of different types of interactions, and will underline computational methods to predict protein interactions and protein function.
Speaker 3 of 5
Alfonso Valencia, Spanish National Cancer Research Centre, Spain
Coevolutionary Information in the Prediction of Global Interactomes and Interaction Regions

Tuesday, March 09 | 5:00PM - 7:00PM
From Molecular Interaction Networks to Function Prediction
Room: Salle de Bal
This session will focus on inferring and characterizing cellular functions and functional moonlighting within the context of different types of interactions, and will underline computational methods to predict protein interactions and protein function.
Speaker 4 of 5
Michael Cusick, Dana-Farber Cancer Institute, USA
Interactome Networks: The Next Decade

Tuesday, March 09 | 5:00PM - 7:00PM
From Molecular Interaction Networks to Function Prediction
Room: Salle de Bal
This session will focus on inferring and characterizing cellular functions and functional moonlighting within the context of different types of interactions, and will underline computational methods to predict protein interactions and protein function.
Speaker 5 of 5
Saikat Chakrabarti, Indian Institute of Chemical Biology, India
Short Talk: Connecting the Functional Dots in Coevolutionary Networks

Tuesday, March 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Salle de Bal Foyer


Tuesday, March 09 | 7:30PM - 10:00PM
Poster Session 2
Room: Salle de Bal


Wednesday, March 10 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac


Wednesday, March 10 | 8:00AM - 11:15AM
Disease Interactome: Disease-Associated Genes, Disease Mutat
ions and Protein Interactions

Room: Salle de Bal
This session will highlight the approach to link disease networks with the experimental biomolecular interaction networks, predict disease associated genes, and elucidate the role of polymorphisms in the manifestation of different diseases.
Speaker 1 of 7
* Dana Pe'er, Memorial Sloan Kettering Cancer Center, USA

Wednesday, March 10 | 8:00AM - 11:15AM
Disease Interactome: Disease-Associated Genes, Disease Mutat
ions and Protein Interactions

Room: Salle de Bal
This session will highlight the approach to link disease networks with the experimental biomolecular interaction networks, predict disease associated genes, and elucidate the role of polymorphisms in the manifestation of different diseases.
Speaker 2 of 7
Andrea Califano, Columbia University, USA
A Molecular Interaction Networks Elucidates Master Regulators of the Mesenchymal Transformation of High-Grade Glioma

Wednesday, March 10 | 8:00AM - 11:15AM
Disease Interactome: Disease-Associated Genes, Disease Mutat
ions and Protein Interactions

Room: Salle de Bal
This session will highlight the approach to link disease networks with the experimental biomolecular interaction networks, predict disease associated genes, and elucidate the role of polymorphisms in the manifestation of different diseases.
Speaker 3 of 7
Aviv Bergman, Albert Einstein College of Medicine, USA
Evolutionary Capacitance as a General Feature of Complex Gene Networks


Wednesday, March 10 | 8:00AM - 11:15AM
Disease Interactome: Disease-Associated Genes, Disease Mutat
ions and Protein Interactions

Room: Salle de Bal
This session will highlight the approach to link disease networks with the experimental biomolecular interaction networks, predict disease associated genes, and elucidate the role of polymorphisms in the manifestation of different diseases.
Speaker 4 of 7
Teresa M. Przytycka, NCBI, NLM, National Institutes of Health, USA
Gene Regulation in the Context of Variations in DNA Sequence and Structure; Relation to Diseases

Wednesday, March 10 | 8:00AM - 11:15AM
Disease Interactome: Disease-Associated Genes, Disease Mutat
ions and Protein Interactions

Room: Salle de Bal
This session will highlight the approach to link disease networks with the experimental biomolecular interaction networks, predict disease associated genes, and elucidate the role of polymorphisms in the manifestation of different diseases.
Speaker 5 of 7
Olga G. Troyanskaya, Princeton University, USA
From Integrated Functional Networks to Understanding Disease

Wednesday, March 10 | 8:00AM - 11:15AM
Disease Interactome: Disease-Associated Genes, Disease Mutat
ions and Protein Interactions

Room: Salle de Bal
This session will highlight the approach to link disease networks with the experimental biomolecular interaction networks, predict disease associated genes, and elucidate the role of polymorphisms in the manifestation of different diseases.
Speaker 6 of 7
Christina S. Leslie, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: Inferring Transcriptional and microRNA-mediated Regulatory Programs in Glioblastoma

Wednesday, March 10 | 8:00AM - 11:15AM
Disease Interactome: Disease-Associated Genes, Disease Mutat
ions and Protein Interactions

Room: Salle de Bal
This session will highlight the approach to link disease networks with the experimental biomolecular interaction networks, predict disease associated genes, and elucidate the role of polymorphisms in the manifestation of different diseases.
Speaker 7 of 7
Richard Notebaart, Radboud University Nijmegen Medical Centre, Netherlands
Short Talk: Function and Evolution of Asymmetric Protein Associations

Wednesday, March 10 | 9:20AM - 9:40AM
Coffee Break
Room: Vercheres


Wednesday, March 10 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, March 10 | 4:30PM - 5:00PM
Coffee Available
Room: Vercheres


Wednesday, March 10 | 5:00PM - 7:00PM
Evolution of Biomolecular Networks
Room: Salle de Bal
This session will give an overview of recent achievements in comparative analysis of protein-protein and protein-DNA interactions in different organisms, their evolutionary conservation (protein-protein interologs and protein-DNA regulogs), evolution of protein binding patterns.
Speaker 1 of 5
* Shoshana Wodak, Hospital for Sick Children, Research Institute, Canada

Wednesday, March 10 | 5:00PM - 7:00PM
Evolution of Biomolecular Networks
Room: Salle de Bal
This session will give an overview of recent achievements in comparative analysis of protein-protein and protein-DNA interactions in different organisms, their evolutionary conservation (protein-protein interologs and protein-DNA regulogs), evolution of protein binding patterns.
Speaker 2 of 5
Trey Ideker, University of California, San Diego, USA
Comparative Analysis of Protein Networks

Wednesday, March 10 | 5:00PM - 7:00PM
Evolution of Biomolecular Networks
Room: Salle de Bal
This session will give an overview of recent achievements in comparative analysis of protein-protein and protein-DNA interactions in different organisms, their evolutionary conservation (protein-protein interologs and protein-DNA regulogs), evolution of protein binding patterns.
Speaker 3 of 5
Anna Panchenko, NIM, National Institutes of Health, USA
Protein Complexes: Evolution and Intrinsic Disorder

Wednesday, March 10 | 5:00PM - 7:00PM
Evolution of Biomolecular Networks
Room: Salle de Bal
This session will give an overview of recent achievements in comparative analysis of protein-protein and protein-DNA interactions in different organisms, their evolutionary conservation (protein-protein interologs and protein-DNA regulogs), evolution of protein binding patterns.
Speaker 4 of 5
Sarah Teichmann, Wellcome Sanger Institute, UK
Evolution and Assembly of Homomeric Protein Complexes

Wednesday, March 10 | 5:00PM - 7:00PM
Evolution of Biomolecular Networks
Room: Salle de Bal
This session will give an overview of recent achievements in comparative analysis of protein-protein and protein-DNA interactions in different organisms, their evolutionary conservation (protein-protein interologs and protein-DNA regulogs), evolution of protein binding patterns.
Speaker 5 of 5
Emmanuel D. Levy, Universite de Montreal, Canada
Short Talk: Are all Protein-Protein Interactions Functional?
Lessons from Evolution


Wednesday, March 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Salle de Bal Foyer


Thursday, March 11 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac


Thursday, March 11 | 8:00AM - 11:15AM
Linking Regulatory Networks to Cellular Function
Room: Salle de Bal
This session focuses on systems approaches to indentify, predict and analyze signal transduction networks in general and posttranslational modification networks in particular.
Speaker 1 of 7
* Hunter B. Fraser, Stanford University, USA

Thursday, March 11 | 8:00AM - 11:15AM
Linking Regulatory Networks to Cellular Function
Room: Salle de Bal
This session focuses on systems approaches to indentify, predict and analyze signal transduction networks in general and posttranslational modification networks in particular.
Speaker 2 of 7
Tony Pawson, Samuel Lunenfeld Research Institute, Canada
Proteomic Analysis of Bidirectional Signaling Networks

Thursday, March 11 | 8:00AM - 11:15AM
Linking Regulatory Networks to Cellular Function
Room: Salle de Bal
This session focuses on systems approaches to indentify, predict and analyze signal transduction networks in general and posttranslational modification networks in particular.
Speaker 3 of 7
Gustavo Stolovitzky, IBM, USA
Systems Biology of Small and Large Scale Gene Regulatory Networks

Thursday, March 11 | 8:00AM - 11:15AM
Linking Regulatory Networks to Cellular Function
Room: Salle de Bal
This session focuses on systems approaches to indentify, predict and analyze signal transduction networks in general and posttranslational modification networks in particular.
Speaker 4 of 7
Eric H. Davidson, California Institute of Technology, USA
Evolutionary Plasticity of Developmental Gene Regulatory Network Architecture

Thursday, March 11 | 8:00AM - 11:15AM
Linking Regulatory Networks to Cellular Function
Room: Salle de Bal
This session focuses on systems approaches to indentify, predict and analyze signal transduction networks in general and posttranslational modification networks in particular.
Speaker 5 of 7
Yitzhak Pilpel, Weizmann Institute of Science, Israel
Adaptive Prediction of Environmental Changes by Microorganisms

Thursday, March 11 | 8:00AM - 11:15AM
Linking Regulatory Networks to Cellular Function
Room: Salle de Bal
This session focuses on systems approaches to indentify, predict and analyze signal transduction networks in general and posttranslational modification networks in particular.
Speaker 6 of 7
Mark D. Biggin, Lawrence Berkeley National Laboratory, USA
Short Talk: Evidence for Quantitative Transcription Networks

Thursday, March 11 | 8:00AM - 11:15AM
Linking Regulatory Networks to Cellular Function
Room: Salle de Bal
This session focuses on systems approaches to indentify, predict and analyze signal transduction networks in general and posttranslational modification networks in particular.
Speaker 7 of 7
Sarath Chandra Janga, MRC Laboratory of Molecular Biology, UK
Short Talk: Dissecting the Expression Dynamics of RNA-Binding Proteins in Posttranscriptional Regulatory Networks

Thursday, March 11 | 9:20AM - 9:40AM
Coffee Break
Room: Vercheres


Thursday, March 11 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Thursday, March 11 | 4:30PM - 5:00PM
Coffee Available
Room: Vercheres


Thursday, March 11 | 5:00PM - 7:00PM
Regulatory Networks and Genetic Polymorphism
Room: Salle de Bal
This session will focus on the use of transcript abundances as quantitative traits. In particular, the speakers will focus on study of expression polymorphism in combination with other system biology approaches to delineate transcriptional mechanism and elucidate the role of disease genes.
Speaker 1 of 5
* Teresa M. Przytycka, NCBI, NLM, National Institutes of Health, USA

Thursday, March 11 | 5:00PM - 7:00PM
Regulatory Networks and Genetic Polymorphism
Room: Salle de Bal
This session will focus on the use of transcript abundances as quantitative traits. In particular, the speakers will focus on study of expression polymorphism in combination with other system biology approaches to delineate transcriptional mechanism and elucidate the role of disease genes.
Speaker 2 of 5
Ivan Ovcharenko, National Institutes of Health, USA
Genome-Wide Discovery of Human Heart Enhancers

Thursday, March 11 | 5:00PM - 7:00PM
Regulatory Networks and Genetic Polymorphism
Room: Salle de Bal
This session will focus on the use of transcript abundances as quantitative traits. In particular, the speakers will focus on study of expression polymorphism in combination with other system biology approaches to delineate transcriptional mechanism and elucidate the role of disease genes.
Speaker 3 of 5
Dana Pe'er, Memorial Sloan Kettering Cancer Center, USA
Driving Mutations: Lessons from Yeast and Cancer

Thursday, March 11 | 5:00PM - 7:00PM
Regulatory Networks and Genetic Polymorphism
Room: Salle de Bal
This session will focus on the use of transcript abundances as quantitative traits. In particular, the speakers will focus on study of expression polymorphism in combination with other system biology approaches to delineate transcriptional mechanism and elucidate the role of disease genes.
Speaker 4 of 5
Rachel B. Brem, University of California, Berkeley, USA
Models of Speciation and Adaptation in Fungi

Thursday, March 11 | 5:00PM - 7:00PM
Regulatory Networks and Genetic Polymorphism
Room: Salle de Bal
This session will focus on the use of transcript abundances as quantitative traits. In particular, the speakers will focus on study of expression polymorphism in combination with other system biology approaches to delineate transcriptional mechanism and elucidate the role of disease genes.
Speaker 5 of 5
Gregory Hannum, University of California, San Diego, USA
Short Talk: Genome-Wide Association Data Reveal a Global Map of Genetic Interactions Amongst Protein Complexes

Thursday, March 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jacques Cartier


Thursday, March 11 | 8:00PM - 11:00PM
Entertainment
Room: Jacques Cartier


Thursday, March 11 | 8:00PM - 11:00PM
Cash Bar
Room: Jacques Cartier


Friday, March 12 | 10:25AM - 10:25AM
Departure


*Session Chair.