Web Desc
Bioactive Lipids: Biochemistry and Diseases
Organizer(s): Shuh Narumiya, Takao Shimizu and Garret A. FitzGerald
Date: June 06 - 11, 2010
Location: Westin Miyako Kyoto, Kyoto, Japan
Sponsored by Astellas Pharma Inc. and Takeda Pharmaceutical Company Limited. Also supported by the Japan Society for the Promotion of Science in cooperation with Kyoto University.
Summary of Meeting:
The world of lipid mediators is expanding. New and unexpected biological functions, biosynthetic pathways and receptors are being revealed for lipids as appreciation grows for their complex interactions with protein and the genome. New actions are still being added to classic mediators such as prostaglandins and leukotrienes. Lipid mediators are now recognized to influence a broad swath of biology from inflammation to allergy, immunity, cardiovascular diseases, cancer and behavior. Advances in lipidomics enable us to monitor dynamics of a variety of lipid mediators simultaneously. In this symposium we invite distinguished scientists to share their progress in this expanding field and to present a comprehensive view on what lipid mediators do in our body. We also invite scientists interested in the translation of such basic science from model systems to an understanding of the role of lipids in human physiology, disease and drug action. Expansion of our understanding of the role of lipid mediators affords the opportunity for novel therapeutic opportunities, examples of which will be discussed in the symposium.
Scholarship Deadline: February 23 2010
Discounted Abstract Deadline: February 23 2010
Abstract Deadline: March 9 2010
Discounted Registration Deadline: April 6 2010
We gratefully acknowledge additional support for this conference from:
Astellas Pharma Inc.
Asubio Pharma Co., Ltd.
Avanti Polar Lipids, Inc.Daiichi Sankyo Co., Ltd.Dainippon Sumitomo Pharma Co., Ltd.Japan Society for the Promotion of Science
Journal of Lipid Research
Kyowa Hakko Kirin Co., Ltd.Mitsubishi Tanabe Pharma CorporationNacalai Tesque, Inc.Novartis Pharma KK Japan
Ono Pharmaceutical Co. Ltd.
Takeda Pharmaceutical Company LimitedThe Uehara Memorial Foundation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Merck Research Laboratories

Minase Research Institute, Ono Pharmaceutical Co. Ltd.

Ono Pharmaceutical Co.Ltd.


Kuniyuki Kano

Keiko Yokota
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Pubget Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI088818-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, June 06 | 3:00PM - 7:30PM
Registration
Room: Mizuho Foyer


Sunday, June 06 | 6:30PM - 7:30PM
Refreshments
Room: Mizuho Foyer


Sunday, June 06 | 7:30PM - 8:30PM
Keynote Address
Room: Mizuho Ballroom

Speaker 1 of 2
* Shuh Narumiya, Kyoto University, Japan

Sunday, June 06 | 7:30PM - 8:30PM
Keynote Address
Room: Mizuho Ballroom

Speaker 2 of 2
Osamu Hayaishi, Osaka Bioscience Institute, Japan
Prostaglandins and Sleep

Monday, June 07 | 7:30AM - 8:30AM
Breakfast
Room: Mizuho Ballroom


Monday, June 07 | 7:30AM - 8:30AM
Poster Setup
Room: Mizuho Ballroom


Monday, June 07 | 8:30AM - 7:00PM
Poster Viewing
Room: Mizuho Ballroom


Monday, June 07 | 8:30AM - 12:00PM
Biochemistry of Lipid Metabolism I
Room: Mizuho Ballroom

Speaker 1 of 8
* Edward A. Dennis, University of California, San Diego, USA

Monday, June 07 | 8:30AM - 12:00PM
Biochemistry of Lipid Metabolism I
Room: Mizuho Ballroom

Speaker 2 of 8
* Jesper Z. Haeggström, Karolinska Institute, Sweden

Monday, June 07 | 8:30AM - 12:00PM
Biochemistry of Lipid Metabolism I
Room: Mizuho Ballroom

Speaker 3 of 8
Takao Shimizu, University of Tokyo, Japan
Turnover of Glycerophospholipids by Deacylation-Reacylation Cycle

Monday, June 07 | 8:30AM - 12:00PM
Biochemistry of Lipid Metabolism I
Room: Mizuho Ballroom

Speaker 4 of 8
Makoto Murakami, Tokyo Metropolitan Institute of Medical Science, Japan
Biological Functions of sPLA2s

Monday, June 07 | 8:30AM - 12:00PM
Biochemistry of Lipid Metabolism I
Room: Mizuho Ballroom

Speaker 5 of 8
Sasanka Ramanadham, UAB Comprehensive Diabetes Center, USA
Involvement of Novel iPLA2beta-Dependent Mechanisms in beta-Cell Apoptosis

Monday, June 07 | 8:30AM - 12:00PM
Biochemistry of Lipid Metabolism I
Room: Mizuho Ballroom

Speaker 6 of 8
William L. Smith, University of Michigan, USA
Cyclooxygenase Homodimers Function as Conformational Heterodimers with Allosteric and Catalytic Subunits

Monday, June 07 | 8:30AM - 12:00PM
Biochemistry of Lipid Metabolism I
Room: Mizuho Ballroom

Speaker 7 of 8
Michael H. Gelb, University of Washington, USA
Short Talk: Phospholipase A2 Mediated Eicosanoid Generation During Inflammation

Monday, June 07 | 8:30AM - 12:00PM
Biochemistry of Lipid Metabolism I
Room: Mizuho Ballroom

Speaker 8 of 8
Claude Wolf, Faculté de Médecine St Antoine, France
Short Talk: Profiling of Liver Triglycerides Reveals Specific Molecular Species Associated with Fatty Liver in Mice

Monday, June 07 | 9:40AM - 10:00AM
Coffee Break
Room: Mizuho Foyer


Monday, June 07 | 12:00PM - 1:00PM
Lunch
Room: Mizuho Ballroom


Monday, June 07 | 12:30PM - 3:00PM
Poster Session 1
Room: Mizuho Ballroom


Monday, June 07 | 2:45PM - 3:00PM
Coffee Available
Room: Mizuho Foyer


Monday, June 07 | 3:00PM - 5:30PM
Biochemistry of Lipid Metabolism II
Room: Mizuho Ballroom

Speaker 1 of 8
* Takao Shimizu, University of Tokyo, Japan

Monday, June 07 | 3:00PM - 5:30PM
Biochemistry of Lipid Metabolism II
Room: Mizuho Ballroom

Speaker 2 of 8
* William L. Smith, University of Michigan, USA

Monday, June 07 | 3:00PM - 5:30PM
Biochemistry of Lipid Metabolism II
Room: Mizuho Ballroom

Speaker 3 of 8
Kikuko Watanabe, Koshien University, Japan
A Novel Type of PGF Synthase belonging to the Thioredoxin-Like Superfamily

Monday, June 07 | 3:00PM - 5:30PM
Biochemistry of Lipid Metabolism II
Room: Mizuho Ballroom

Speaker 4 of 8
Jesper Z. Haeggström, Karolinska Institute, Sweden
Structure and function of LTA4 hydrolase, LTC4 synthase, and related enzymes

Monday, June 07 | 3:00PM - 5:30PM
Biochemistry of Lipid Metabolism II
Room: Mizuho Ballroom

Speaker 5 of 8
B. Therese Kinsella, University College Dublin, Ireland
Biochemistry of the Human Prostacyclin Receptor

Monday, June 07 | 3:00PM - 5:30PM
Biochemistry of Lipid Metabolism II
Room: Mizuho Ballroom

Speaker 6 of 8
Edward A. Dennis, University of California, San Diego, USA
Short Talk: Lipidomics of Eicosanoids in Cell Signaling and Inflammation

Monday, June 07 | 3:00PM - 5:30PM
Biochemistry of Lipid Metabolism II
Room: Mizuho Ballroom

Speaker 7 of 8
Toshiko Suzuki-Yamamoto, Okayama Prefectural University, Japan
Short Talk: Localization of Prostaglandin F2alpha Synthase and Receptor FP in the Rat Cerebellum

Monday, June 07 | 3:00PM - 5:30PM
Biochemistry of Lipid Metabolism II
Room: Mizuho Ballroom

Speaker 8 of 8
Marcia E. Newcomer, Louisiana State University, USA
Short Talk: The Crystal Structure of Human 5-Lipoxygenase

Monday, June 07 | 5:30PM - 5:30PM
On Own for Dinner


Tuesday, June 08 | 7:30AM - 8:30AM
Breakfast
Room: Mizuho Ballroom


Tuesday, June 08 | 8:30AM - 12:00PM
Biochemistry of Lipid Metabolism III
Room: Mizuho Ballroom

Speaker 1 of 8
* Jerold J. Chun, The Scripps Research Institute, USA

Tuesday, June 08 | 8:30AM - 12:00PM
Biochemistry of Lipid Metabolism III
Room: Mizuho Ballroom

Speaker 2 of 8
* Kikuko Watanabe, Koshien University, Japan

Tuesday, June 08 | 8:30AM - 12:00PM
Biochemistry of Lipid Metabolism III
Room: Mizuho Ballroom

Speaker 3 of 8
Robert C. Murphy, University of Colorado Denver, USA
Transcellular Biosynthesis of Leukotrienes in vivo

Tuesday, June 08 | 8:30AM - 12:00PM
Biochemistry of Lipid Metabolism III
Room: Mizuho Ballroom

Speaker 4 of 8
Alan R. Brash, Vanderbilt University Medical Center, USA
Lipoxygenases, Essential Fatty Acids, and the Epidermis

Tuesday, June 08 | 8:30AM - 12:00PM
Biochemistry of Lipid Metabolism III
Room: Mizuho Ballroom

Speaker 5 of 8
Helena Idborg, Karolinska Institute, Sweden
Short Talk: Evaluation of Urinary Prostaglandin E2 Metabolite as a Biomarker of Inflammation

Tuesday, June 08 | 8:30AM - 12:00PM
Biochemistry of Lipid Metabolism III
Room: Mizuho Ballroom

Speaker 6 of 8
Michal L. Schwartzman, New York Medical College, USA
Cytochrome P450-Derived EETs and HETEs in Vascular Biology

Tuesday, June 08 | 8:30AM - 12:00PM
Biochemistry of Lipid Metabolism III
Room: Mizuho Ballroom

Speaker 7 of 8
Junken Aoki, Tohoku University, Japan
Autotaxin and LPA Signaling in Cardiovascular Development

Tuesday, June 08 | 8:30AM - 12:00PM
Biochemistry of Lipid Metabolism III
Room: Mizuho Ballroom

Speaker 8 of 8
Yutaka Yatomi, Graduate School of Medicine, The University of Tokyo, Japan
Short Talk: Clinical Introduction of Plasma Lysophosphatidic Acid and Serum Autotaxin Assays

Tuesday, June 08 | 9:40AM - 10:00AM
Coffee Break
Room: Mizuho Foyer


Tuesday, June 08 | 12:00PM - 12:00PM
On Own for Lunch and Recreation


Tuesday, June 08 | 12:00PM - 1:00PM
Poster Setup
Room: Mizuho Ballroom


Tuesday, June 08 | 1:00PM - 9:30PM
Poster Viewing
Room: Mizuho Ballroom


Tuesday, June 08 | 3:45PM - 4:00PM
Coffee Available
Room: Mizuho Foyer


Tuesday, June 08 | 4:00PM - 6:30PM
Immunoregulation
Room: Mizuho Ballroom

Speaker 1 of 8
* Andrew D. Luster, Massachusetts General Hospital, USA

Tuesday, June 08 | 4:00PM - 6:30PM
Immunoregulation
Room: Mizuho Ballroom

Speaker 2 of 8
* Sarah Spiegel, Virginia Commonwealth University, USA

Tuesday, June 08 | 4:00PM - 6:30PM
Immunoregulation
Room: Mizuho Ballroom

Speaker 3 of 8
Suzanne Ostrand-Rosenberg, University of Maryland, USA
Prostaglandin E2 Drives Immune Suppression in the Tumor Microenvironment

Tuesday, June 08 | 4:00PM - 6:30PM
Immunoregulation
Room: Mizuho Ballroom

Speaker 4 of 8
Shuh Narumiya, Kyoto University, Japan
Prostanoids and Immune Inflammation

Tuesday, June 08 | 4:00PM - 6:30PM
Immunoregulation
Room: Mizuho Ballroom

Speaker 5 of 8
Kenji Chiba, Mitsubishi Tanabe Pharma Corporation, Japan
Immunoregulation by the Sphingosine 1-Phosphate Receptor Modulator, FTY720

Tuesday, June 08 | 4:00PM - 6:30PM
Immunoregulation
Room: Mizuho Ballroom

Speaker 6 of 8
Andreas Zimmer, University of Bonn, Germany
Endocannabinoids and Immunoregulation

Tuesday, June 08 | 4:00PM - 6:30PM
Immunoregulation
Room: Mizuho Ballroom

Speaker 7 of 8
Doina Ganea, Temple University School of Medicine, USA
Short Talk: Dendritic Cells – A Crucial Target for the Anti-Inflammatory Effects of Docosahexaenoic Acid (DHA)

Tuesday, June 08 | 4:00PM - 6:30PM
Immunoregulation
Room: Mizuho Ballroom

Speaker 8 of 8
Marc Stephan Lamphier, Eisai Research Institute, USA
Short Talk: A Novel Antagonist of the Prostaglandin E2 Receptor EP4 Inhibits Th1 Differentiation and Th17 Expansion and is Orally Active in Arthritis Models

Tuesday, June 08 | 6:30PM - 7:30PM
Social Hour with Lite Bites
Room: Mizuho Ballroom


Tuesday, June 08 | 7:00PM - 9:30PM
Poster Session 2
Room: Mizuho Ballroom


Wednesday, June 09 | 7:30AM - 8:30AM
Breakfast
Room: Mizuho Ballroom


Wednesday, June 09 | 8:30AM - 12:00PM
Allergy and Inflammation
Room: Mizuho Ballroom

Speaker 1 of 8
* Shuh Narumiya, Kyoto University, Japan

Wednesday, June 09 | 8:30AM - 12:00PM
Allergy and Inflammation
Room: Mizuho Ballroom

Speaker 2 of 8
* Colin D. Funk, Queen's University, Canada

Wednesday, June 09 | 8:30AM - 12:00PM
Allergy and Inflammation
Room: Mizuho Ballroom

Speaker 3 of 8
K. Frank Austen, Harvard Medical School, USA
The Integrated Biology of the Cysteinyl Leukotrienes and their Receptors

Wednesday, June 09 | 8:30AM - 12:00PM
Allergy and Inflammation
Room: Mizuho Ballroom

Speaker 4 of 8
Andrew D. Luster, Massachusetts General Hospital, USA
Lipid-Cytokine-Chemokine Cascades Control Leukocyte Trafficking in Disease

Wednesday, June 09 | 8:30AM - 12:00PM
Allergy and Inflammation
Room: Mizuho Ballroom

Speaker 5 of 8
Jilly F. Evans, PharmAkea Therapeutics, USA
Development of FLAP Inhibitors

Wednesday, June 09 | 8:30AM - 12:00PM
Allergy and Inflammation
Room: Mizuho Ballroom

Speaker 6 of 8
Sarah Spiegel, Virginia Commonwealth University, USA
Novel Intracellular Targets of Sphingosine-1-Phosphate

Wednesday, June 09 | 8:30AM - 12:00PM
Allergy and Inflammation
Room: Mizuho Ballroom

Speaker 7 of 8
Yumiko Imai, National Institute of Biomedical Innovation, Japan
Short Talk: Hyper-Response of Innate Immune System Triggered by Oxidative Stress and Oxidized Phospholipids Controls the Severity of Acute Lung Injury

Wednesday, June 09 | 8:30AM - 12:00PM
Allergy and Inflammation
Room: Mizuho Ballroom

Speaker 8 of 8
Susanna Louise Lundström, Karolinska Institutet, Sweden
Short Talk: Allergic Asthmatics Exhibit Altered Responses in Oxylipin Profile Compared to Healthy and Asthmatic Controls following Allergen Provocation

Wednesday, June 09 | 9:40AM - 10:00AM
Coffee Break
Room: Mizuho Foyer


Wednesday, June 09 | 12:00PM - 12:00PM
On Own for Lunch and Recreation


Wednesday, June 09 | 12:00PM - 1:00PM
Poster Setup
Room: Mizuho Ballroom


Wednesday, June 09 | 1:00PM - 9:30PM
Poster Viewing
Room: Mizuho Ballroom


Wednesday, June 09 | 3:45PM - 4:00PM
Coffee Available
Room: Mizuho Foyer


Wednesday, June 09 | 4:00PM - 5:50PM
Nervous System
Room: Mizuho Ballroom

Speaker 1 of 6
* Garret A. FitzGerald, University of Pennsylvania, USA

Wednesday, June 09 | 4:00PM - 5:50PM
Nervous System
Room: Mizuho Ballroom

Speaker 2 of 6
* Yoshihiro Urade, Osaka Bioscience Institute, Japan

Wednesday, June 09 | 4:00PM - 5:50PM
Nervous System
Room: Mizuho Ballroom

Speaker 3 of 6
Jerold J. Chun, The Scripps Research Institute, USA
Lysophospholipid Signaling in Disease

Wednesday, June 09 | 4:00PM - 5:50PM
Nervous System
Room: Mizuho Ballroom

Speaker 4 of 6
Daniele Piomelli, University of California, Irvine, USA
Endocannabinoids and the Brain

Wednesday, June 09 | 4:00PM - 5:50PM
Nervous System
Room: Mizuho Ballroom

Speaker 5 of 6
Shuntaro Hara, Showa University, Japan
Short Talk: Involvement of Microsomal Prostaglandin E Synthase-1 (mPGES-1) in Alzheimer’s Disease

Wednesday, June 09 | 4:00PM - 5:50PM
Nervous System
Room: Mizuho Ballroom

Speaker 6 of 6
Fumiaki Kojima, Asahikawa Medical College, Japan
Short Talk: Prostaglandin E2 Exacerbates Ischemic Brain Injury via the EP4 Receptor Subtype in Mice Subjected to a Middle Cerebral Artery Occlusion

Wednesday, June 09 | 5:50PM - 6:30PM
Cardiovascular Diseases I
Room: Mizuho Ballroom

Speaker 1 of 1
Shaun R. Coughlin, University of California, San Francisco, USA
Sphingosine-1-Phosphate in the Plasma Compartment Regulates Basal and Stimulated Vascular Leak in Mouse

Wednesday, June 09 | 6:30PM - 7:30PM
Social Hour with Lite Bites
Room: Mizuho Ballroom


Wednesday, June 09 | 7:00PM - 9:30PM
Poster Session 3
Room: Mizuho Ballroom


Thursday, June 10 | 7:30AM - 8:30AM
Breakfast
Room: Mizuho Ballroom


Thursday, June 10 | 8:30AM - 12:00PM
Cardiovascular Diseases II
Room: Mizuho Ballroom

Speaker 1 of 8
* Shaun R. Coughlin, University of California, San Francisco, USA

Thursday, June 10 | 8:30AM - 12:00PM
Cardiovascular Diseases II
Room: Mizuho Ballroom

Speaker 2 of 8
* Michal L. Schwartzman, New York Medical College, USA

Thursday, June 10 | 8:30AM - 12:00PM
Cardiovascular Diseases II
Room: Mizuho Ballroom

Speaker 3 of 8
Garret A. FitzGerald, University of Pennsylvania, USA
Cardiovascular Biology of the Prostanoids

Thursday, June 10 | 8:30AM - 12:00PM
Cardiovascular Diseases II
Room: Mizuho Ballroom

Speaker 4 of 8
Colin D. Funk, Queen's University, Canada
Eicosanoids in Cardiovascular Disease

Thursday, June 10 | 8:30AM - 12:00PM
Cardiovascular Diseases II
Room: Mizuho Ballroom

Speaker 5 of 8
Paola Patrignani, G. D'Annunzio University, Italy
Role of Prostanoids in Endothelial Biology

Thursday, June 10 | 8:30AM - 12:00PM
Cardiovascular Diseases II
Room: Mizuho Ballroom

Speaker 6 of 8
Alison M. Strack, Merck & Co., USA
Niacin and DP1 Antagonists: Studies in Mouse Models of Atherosclerosis

Thursday, June 10 | 8:30AM - 12:00PM
Cardiovascular Diseases II
Room: Mizuho Ballroom

Speaker 7 of 8
Barry Rubin, Toronto General Hospital, Canada
Short Talk: Lack of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) in Bone Marrow Derived Leucocytes Impairs Left Ventricular Remodelling and Increases Mortality After Myocardial Infarction

Thursday, June 10 | 8:30AM - 12:00PM
Cardiovascular Diseases II
Room: Mizuho Ballroom

Speaker 8 of 8
Yoshinori Katsumata, Keio University, Japan
Short Talk: Prostaglandin D2 Transduces Signals into Cardiomyocytes Independently of Canonical PGD2 Receptor

Thursday, June 10 | 9:40AM - 10:00AM
Coffee Break
Room: Mizuho Foyer


Thursday, June 10 | 12:00PM - 12:00PM
On Own for Lunch and Recreation


Thursday, June 10 | 3:45PM - 4:00PM
Coffee Available
Room: Mizuho Foyer


Thursday, June 10 | 4:00PM - 6:30PM
Immunomodulation by Lipid Mediators and Related Drugs
Room: Mizuho Ballroom

Speaker 1 of 6
* Jilly F. Evans, PharmAkea Therapeutics, USA

Thursday, June 10 | 4:00PM - 6:30PM
Immunomodulation by Lipid Mediators and Related Drugs
Room: Mizuho Ballroom

Speaker 2 of 6
* Alison M. Strack, Merck & Co., USA

Thursday, June 10 | 4:00PM - 6:30PM
Immunomodulation by Lipid Mediators and Related Drugs
Room: Mizuho Ballroom

Speaker 3 of 6
Yoshihiro Urade, Osaka Bioscience Institute, Japan
PGD2 in Neuroinflammation and Muscular Dystrophy

Thursday, June 10 | 4:00PM - 6:30PM
Immunomodulation by Lipid Mediators and Related Drugs
Room: Mizuho Ballroom

Speaker 4 of 6
Takayuki Maruyama, Ono Pharmaceutical Co.Ltd., Japan
Possibilities of EP Agonists and Antagonists for Novel Therapies

Thursday, June 10 | 4:00PM - 6:30PM
Immunomodulation by Lipid Mediators and Related Drugs
Room: Mizuho Ballroom

Speaker 5 of 6
David F. Woodward, Allergan, Inc., USA
Short Talk: Design of Antagonists for PGF2alpha-Ethanolamide and PGE2-Glyceryl Ester by Using a Single Oxabicycloheptane Scaffold

Thursday, June 10 | 4:00PM - 6:30PM
Immunomodulation by Lipid Mediators and Related Drugs
Room: Mizuho Ballroom

Speaker 6 of 6
Masataka Majima, Kitasato University School of Medicine, Japan
Short Talk: Recruitment of Mast Cells to the Tumor Microenvironment via the High Affinity Leukotriene B4 Receptor Regulates Tumor Stromal Profiles and Tumor-Associated Angiogenesis

Thursday, June 10 | 6:30PM - 7:30PM
Social Hour with Lite Bites
Room: Mizuho Ballroom


Thursday, June 10 | 6:30PM - 8:30PM
Entertainment
Room: Mizuho Ballroom


Friday, June 11 | 10:25AM - 10:25AM
Departure


*Session Chair.