Web Desc
Innate Immunity: Mechanisms Linking with Adaptive Immunity
Organizer(s): Luke A.J. O'Neill, Kate A. Fitzgerald and Averil I. Ma
Date: June 07 - 12, 2010
Location: Trinity College Dublin, Dublin 2, Ireland
Organized in Collaboration with Science Foundation Ireland
For important information on the coronavirus, please click here
Summary of Meeting:
In the past 5 years there have been remarkable advances in our understanding of the molecular basis of innate immunity. We now have considerable detail on the major classes of innate immune receptors that sense pathogens and provoke immune and inflammatory responses. These include the Toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-I-like receptors (RLRs). The role these receptors play in host defense against microbes has been studied, their signaling pathways elucidated, and their roles in infectious and inflammatory diseases examined in detail. As well as stimulating innate immunity via induction of various effector mechanisms, these receptors also participate in the establishment of adaptive immunity. This occurs via the induction of key cytokines to promote T and B cell development and activation, and also via the induction of co-stimulatory molecules on the surface of dendritic cells, notably CD80 and CD86. A final aspect concerns adjuvancy – microbial or synthetic agents that activate these receptors act as powerful adjuvants required for the establishment of memory responses. This conference will bring together scientists working on innate immune mechanisms activated by these receptors, and will have as a key focus the ability of these receptors and the responses they elicit to promote adaptive immunity. The conference will therefore be of interest to many investigators interested in immunity and the role the immune system plays in disease.
Meeting is full. Please contact info@keystonesymposia.org for questions or to be placed on a waitlist.


We gratefully acknowledge additional support for this conference from:
AbD SerotecFáilte IrelandJDRFScience Foundation Ireland
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Opsona Therapeutics Ltd


Lakshmi Bhagat
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Pubget Inc.SAGE Publications
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI088869-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, June 07 | 3:00PM - 7:30PM
Registration
Room: Lower Concourse


Monday, June 07 | 6:30PM - 7:30PM
Refreshments
Room: Lower Concourse


Monday, June 07 | 7:30PM - 8:30PM
Keynote Address
Room: Burke Theatre/Beckett Rooms

Speaker 1 of 2
* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland

Monday, June 07 | 7:30PM - 8:30PM
Keynote Address
Room: Burke Theatre/Beckett Rooms

Speaker 2 of 2
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Innate Control of Adaptive Immunity

Tuesday, June 08 | 7:30AM - 8:30AM
Breakfast
Room: At Lodging Location


Tuesday, June 08 | 7:30AM - 8:30AM
Poster Setup
Room: Beckett Rooms/Lower Concourse


Tuesday, June 08 | 8:30AM - 3:00PM
Poster Viewing
Room: Beckett Rooms/Lower Concourse


Tuesday, June 08 | 8:30AM - 11:45AM
The Modulation of Innate and Adaptive Immune Responses by In
nate Receptors

Room: Burke Theatre/Beckett Rooms

Speaker 1 of 6
Akira Shizuo, Osaka University, Japan
Functional Analysis of TLR Inducible Genes by Gene Targeting

Tuesday, June 08 | 8:30AM - 11:45AM
The Modulation of Innate and Adaptive Immune Responses by In
nate Receptors

Room: Burke Theatre/Beckett Rooms

Speaker 2 of 6
* Alberto Mantovani, Humanitas University, Italy
The Interplay between Cellular and Humoral Innate Immunity: The Long Pentraxin PTX3 as a Paradigm

Tuesday, June 08 | 8:30AM - 11:45AM
The Modulation of Innate and Adaptive Immune Responses by In
nate Receptors

Room: Burke Theatre/Beckett Rooms

Speaker 3 of 6
Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA
Phagosomes and Adaptive Immunity

Tuesday, June 08 | 8:30AM - 11:45AM
The Modulation of Innate and Adaptive Immune Responses by In
nate Receptors

Room: Burke Theatre/Beckett Rooms

Speaker 4 of 6
* Mihai G. Netea, Radboud University, Netherlands
Modulation of Antifungal Immune Responses by Innate Receptors


Tuesday, June 08 | 8:30AM - 11:45AM
The Modulation of Innate and Adaptive Immune Responses by In
nate Receptors

Room: Burke Theatre/Beckett Rooms

Speaker 5 of 6
Michael C. Abt, Sloan Kettering Institute, USA
Short Talk: Signals Derived from Intestinal Microbial Communities
Regulate Anti-Viral Immunity


Tuesday, June 08 | 8:30AM - 11:45AM
The Modulation of Innate and Adaptive Immune Responses by In
nate Receptors

Room: Burke Theatre/Beckett Rooms

Speaker 6 of 6
Anna M. Hansen, Medimmune, USA
Short Talk: An Innate, Non-NK T Cell with Memory-Like Phenotype Produces Large Amounts of IL-17 Independently of IL-6 and IL-21

Tuesday, June 08 | 9:40AM - 10:00AM
Coffee Break
Room: Lower Concourse


Tuesday, June 08 | 11:45AM - 12:45PM
Lunch
Room: Dining Hall/Atrium/Java Vaults


Tuesday, June 08 | 12:00PM - 2:30PM
Poster Session 1
Room: Beckett Rooms/Lower Concourse


Tuesday, June 08 | 2:30PM - 3:00PM
Coffee Available
Room: Lower Concourse


Tuesday, June 08 | 3:00PM - 5:00PM
Autoimmunity as a Consequence of Innate Immunity Defects
Room: Burke Theatre/Beckett Rooms

Speaker 1 of 4
Robert L. Coffman, Dynavax Technologies, USA
Targeting TLR7 and TLR9 in Autoimmune Disease

Tuesday, June 08 | 3:00PM - 5:00PM
Autoimmunity as a Consequence of Innate Immunity Defects
Room: Burke Theatre/Beckett Rooms

Speaker 2 of 4
* Jos van der Meer, Nijmegen Institute for Infection, Netherlands
The auto-inflammatory syndromes

Tuesday, June 08 | 3:00PM - 5:00PM
Autoimmunity as a Consequence of Innate Immunity Defects
Room: Burke Theatre/Beckett Rooms

Speaker 3 of 4
* Averil I. Ma, University of California, San Francisco, USA
Ubiquitination and Innate Immunity

Tuesday, June 08 | 3:00PM - 5:00PM
Autoimmunity as a Consequence of Innate Immunity Defects
Room: Burke Theatre/Beckett Rooms

Speaker 4 of 4
Dominik Schenten, Yale University, USA
Short Talk: The Role of TLR-Induced IL-6 and IL-1 in the Control of Adaptive Immunity

Tuesday, June 08 | 5:00PM - 5:00PM
On Own for Dinner


Wednesday, June 09 | 7:30AM - 8:30AM
Breakfast
Room: At Lodging Location


Wednesday, June 09 | 8:30AM - 11:45AM
Evolution of Innate and Adaptive Immunity
Room: Burke Theatre/Beckett Rooms

Speaker 1 of 6
* Max D. Cooper, Emory University, USA
Evolution of the Adaptive Immune System

Wednesday, June 09 | 8:30AM - 11:45AM
Evolution of Innate and Adaptive Immunity
Room: Burke Theatre/Beckett Rooms

Speaker 2 of 6
* Gary W. Litman, University of South Florida, USA
The Evolution of Immune Receptor Diversity

Wednesday, June 09 | 8:30AM - 11:45AM
Evolution of Innate and Adaptive Immunity
Room: Burke Theatre/Beckett Rooms

Speaker 3 of 6
Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
NLR Proteins: From Plants to Animals

Wednesday, June 09 | 8:30AM - 11:45AM
Evolution of Innate and Adaptive Immunity
Room: Burke Theatre/Beckett Rooms

Speaker 4 of 6
Neal Silverman, University of Massachusetts Medical School, USA
What the Fly has Taught us about Innate Immunity: New Lessons for NF-kappaB Signaling?

Wednesday, June 09 | 8:30AM - 11:45AM
Evolution of Innate and Adaptive Immunity
Room: Burke Theatre/Beckett Rooms

Speaker 5 of 6
A. Neil Barclay, University of Oxford, UK
Short Talk: The Evolution and Ligands of Macrophage Paired Receptors

Wednesday, June 09 | 8:30AM - 11:45AM
Evolution of Innate and Adaptive Immunity
Room: Burke Theatre/Beckett Rooms

Speaker 6 of 6
Gregory Ian Vladimer, Allcyte GmbH, Austria
Short Talk: NLRP12 and Other Inflammasome Components Participate in the Resistance to Yersinia pestis Producing a Potent LPS

Wednesday, June 09 | 9:40AM - 10:00AM
Coffee Break
Room: Lower Concourse


Wednesday, June 09 | 11:45AM - 12:45PM
Lunch
Room: Dining Hall/Atrium/Java Vaults


Wednesday, June 09 | 11:45AM - 12:45PM
Poster Setup
Room: Beckett Rooms/Lower Concourse


Wednesday, June 09 | 12:45PM - 2:45PM
Workshop
Room: Burke Theatre/Beckett Rooms

Speaker 1 of 7
* Averil I. Ma, University of California, San Francisco, USA

Wednesday, June 09 | 12:45PM - 2:45PM
Workshop
Room: Burke Theatre/Beckett Rooms

Speaker 2 of 7
Amy Grace Hise, Case Western Reserve University, USA
Innate Immune Host Defense to Fungal Pathogens

Wednesday, June 09 | 12:45PM - 2:45PM
Workshop
Room: Burke Theatre/Beckett Rooms

Speaker 3 of 7
Clare E. Bryant, University of Cambridge, UK
Allergen Lipid Binding Proteins (Alps) Sensitise Ligand Induced Activation of TLR4: A Common Mechanism of Allergen Recognition?

Wednesday, June 09 | 12:45PM - 2:45PM
Workshop
Room: Burke Theatre/Beckett Rooms

Speaker 4 of 7
Paul J. Hertzog, Hudson Institute of Medical Research, Australia
Regulation of Mucosal Immunity by a New Interferon (IFNepsilon) with Unusual Properties Evolved to Protect Reproductive Tract from Bacterial and Viral Infection

Wednesday, June 09 | 12:45PM - 2:45PM
Workshop
Room: Burke Theatre/Beckett Rooms

Speaker 5 of 7
Mirjam Kool, Erasmus MC, Netherlands
An Unexpected Role for Uric Acid as an Inflammatory Mediator of Allergic Asthma

Wednesday, June 09 | 12:45PM - 2:45PM
Workshop
Room: Burke Theatre/Beckett Rooms

Speaker 6 of 7
Susan B. Carpenter, University of California, Santa Cruz, USA
TRIL: A Novel Modulator of TLR4 Signaling is also Required for TLR3 Mediated Immune Responses

Wednesday, June 09 | 12:45PM - 2:45PM
Workshop
Room: Burke Theatre/Beckett Rooms

Speaker 7 of 7
Shruti Sharma, University of Massachusetts Medical School, USA
Innate Immune Recognition of a Novel AT-rich DNA Motif in the P. falciparum Genome.

Wednesday, June 09 | 2:45PM - 3:00PM
Coffee Available
Room: Lower Concourse


Wednesday, June 09 | 3:00PM - 5:00PM
The Role of Innate Receptors in Adjuvancy
Room: Burke Theatre/Beckett Rooms

Speaker 1 of 4
* Kingston H.G. Mills, Trinity College Dublin, Ireland
Activation and Manipulation of TLR and NLR Signalling Pathways in Dendritic Cells for Selective Induction of T Cell Responses

Wednesday, June 09 | 3:00PM - 5:00PM
The Role of Innate Receptors in Adjuvancy
Room: Burke Theatre/Beckett Rooms

Speaker 2 of 4
Alan Sher, NIAID, National Institutes of Health, USA
Critical Role for IL-1R Signaling and the Inflammasome in the Th1/Th17 cell Adjuvant Activity of Mycobacteria

Wednesday, June 09 | 3:00PM - 5:00PM
The Role of Innate Receptors in Adjuvancy
Room: Burke Theatre/Beckett Rooms

Speaker 3 of 4
* Bart N. Lambrecht, VIB, Ghent University, Belgium
Molecular Basis for Alum Adjuvancy

Wednesday, June 09 | 3:00PM - 5:00PM
The Role of Innate Receptors in Adjuvancy
Room: Burke Theatre/Beckett Rooms

Speaker 4 of 4
Sheri Dubey, Merck & Co., Inc., USA
Short Talk: Novel TLR9 Agonists Combined with Alum for Use as Vaccine Adjuvants

Wednesday, June 09 | 5:00PM - 6:00PM
Social Hour with Lite Bites
Room: Lower Concourse


Wednesday, June 09 | 5:30PM - 8:00PM
Poster Session 2
Room: Beckett Rooms/Lower Concourse


Thursday, June 10 | 7:30AM - 8:30AM
Breakfast
Room: At Lodging Location


Thursday, June 10 | 7:30AM - 8:30AM
Poster Setup
Room: Beckett Rooms/Lower Concourse


Thursday, June 10 | 8:30AM - 3:00PM
Poster Viewing
Room: Beckett Rooms/Lower Concourse


Thursday, June 10 | 8:30AM - 11:45AM
Control of T Cell Subsets by Innate Immune Signals
Room: Burke Theatre/Beckett Rooms

Speaker 1 of 7
* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland

Thursday, June 10 | 8:30AM - 11:45AM
Control of T Cell Subsets by Innate Immune Signals
Room: Burke Theatre/Beckett Rooms

Speaker 2 of 7
* Laurence A. Turka, Rheos Medicines, USA
Regulation of T Lymphocytes by 'Innate Immune Pathways'

Thursday, June 10 | 8:30AM - 11:45AM
Control of T Cell Subsets by Innate Immune Signals
Room: Burke Theatre/Beckett Rooms

Speaker 3 of 7
Shimon Sakaguchi, Osaka University, Japan
Regulatory T Cells in Innate and Adaptive Immunity

Thursday, June 10 | 8:30AM - 11:45AM
Control of T Cell Subsets by Innate Immune Signals
Room: Burke Theatre/Beckett Rooms

Speaker 4 of 7
Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA
Omitting Felony by Switching Fate: TGF-beta and Retinoic Acid Mediate Lineage Conversion of CD4 Th Cells to CD8 CTLs

Thursday, June 10 | 8:30AM - 11:45AM
Control of T Cell Subsets by Innate Immune Signals
Room: Burke Theatre/Beckett Rooms

Speaker 5 of 7
Ed C. Lavelle, Trinity College Dublin, Ireland

Thursday, June 10 | 8:30AM - 11:45AM
Control of T Cell Subsets by Innate Immune Signals
Room: Burke Theatre/Beckett Rooms

Speaker 6 of 7
Aisling Dunne, Trinity College Dublin, Ireland
Short Talk: Inflammasome Activation by Adenylate Cyclase Toxin Directs TH17 Responses and Protection Against Bordetella Pertussis

Thursday, June 10 | 8:30AM - 11:45AM
Control of T Cell Subsets by Innate Immune Signals
Room: Burke Theatre/Beckett Rooms

Speaker 7 of 7
Mattias Enoksson, Mabtech AB, Sweden
Short Talk: Mast Cells as Novel Sensors of Cell Injury through Interleukin-33 Recognition

Thursday, June 10 | 9:40AM - 10:00AM
Coffee Break
Room: Lower Concourse


Thursday, June 10 | 11:45AM - 12:45PM
Lunch
Room: Dining Hall/Atrium/Java Vaults


Thursday, June 10 | 12:00PM - 2:30PM
Poster Session 3
Room: Beckett Rooms/Lower Concourse


Thursday, June 10 | 2:30PM - 3:00PM
Coffee Available
Room: Lower Concourse


Thursday, June 10 | 3:00PM - 5:00PM
Innate Immune Mechanisms: Molecular and Structural Aspects
Room: Burke Theatre/Beckett Rooms

Speaker 1 of 4
* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Novel Components in Innate Immune Signaling

Thursday, June 10 | 3:00PM - 5:00PM
Innate Immune Mechanisms: Molecular and Structural Aspects
Room: Burke Theatre/Beckett Rooms

Speaker 2 of 4
* Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Inflammasomes and Anti-Viral Responses

Thursday, June 10 | 3:00PM - 5:00PM
Innate Immune Mechanisms: Molecular and Structural Aspects
Room: Burke Theatre/Beckett Rooms

Speaker 3 of 4
Eicke Latz, University of Bonn, Germany
Regulation of NLRP3 and AIM2 Inflammasome Signaling

Thursday, June 10 | 3:00PM - 5:00PM
Innate Immune Mechanisms: Molecular and Structural Aspects
Room: Burke Theatre/Beckett Rooms

Speaker 4 of 4
Tilmann Bürckstümmer, Haplogen Genomics, Austria
Short Talk: Functional Dissection of the TBK1 Molecular Machine

Thursday, June 10 | 5:00PM - 5:00PM
On Own for Dinner


Friday, June 11 | 7:30AM - 8:30AM
Breakfast
Room: At Lodging Location


Friday, June 11 | 7:30AM - 8:30PM
Poster Setup
Room: Beckett Rooms/Lower Concourse


Friday, June 11 | 8:30AM - 3:00PM
Poster Viewing
Room: Beckett Rooms/Lower Concourse


Friday, June 11 | 8:30AM - 11:30AM
Therapeutic Manipulation of Innate Immunity in Inflammatory
Diseases

Room: Burke Theatre/Beckett Rooms

Speaker 1 of 6
* Anthony J. Coyle, Pfizer, USA
Role of Type I Interferons in Autoimmune Disease

Friday, June 11 | 8:30AM - 11:30AM
Therapeutic Manipulation of Innate Immunity in Inflammatory
Diseases

Room: Burke Theatre/Beckett Rooms

Speaker 2 of 6
Carla V. Rothlin, Yale University, USA
TAMing Inflammation in vivo

Friday, June 11 | 8:30AM - 11:30AM
Therapeutic Manipulation of Innate Immunity in Inflammatory
Diseases

Room: Burke Theatre/Beckett Rooms

Speaker 3 of 6
Nicola La Monica, Janssen Pharmaceutical, USA
Synthetic Agonists and Antagonists of Toll-like Receptor 7, 8, and 9

Friday, June 11 | 8:30AM - 11:30AM
Therapeutic Manipulation of Innate Immunity in Inflammatory
Diseases

Room: Burke Theatre/Beckett Rooms

Speaker 4 of 6
* Andrew Parker, Zealand Pharma A/S, Denmark
Targeting TLR2 in Ischemic Organ Damage

Friday, June 11 | 8:30AM - 11:30AM
Therapeutic Manipulation of Innate Immunity in Inflammatory
Diseases

Room: Burke Theatre/Beckett Rooms

Speaker 5 of 6
Alison A. Humbles, MedImmune, LLC, USA
Short Talk: RAGE Deficiency Protects Mice from RSV Infection

Friday, June 11 | 8:30AM - 11:30AM
Therapeutic Manipulation of Innate Immunity in Inflammatory
Diseases

Room: Burke Theatre/Beckett Rooms

Speaker 6 of 6
Greg CA Elson, NovImmune SA, Switzerland
Short Talk: Mechanistic Studies Reveal the Mode of Action of Highly Potent TLR4 Neutralizing MAbs

Friday, June 11 | 9:40AM - 10:00AM
Coffee Break
Room: Lower Concourse


Friday, June 11 | 11:30AM - 12:30PM
Lunch
Room: Lower Concourse


Friday, June 11 | 12:00PM - 2:30PM
Poster Session 4
Room: Beckett Rooms/Lower Concourse


Friday, June 11 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Concourse


Friday, June 11 | 5:00PM - 7:15PM
Pathogen-Specific Responses
Room: Burke Theatre/Beckett Rooms

Speaker 1 of 4
* Tracy Hussell, University of Manchester, UK
The Role of Innate Immunity in Host Defence against
Respiratory Pathogens


Friday, June 11 | 5:00PM - 7:15PM
Pathogen-Specific Responses
Room: Burke Theatre/Beckett Rooms

Speaker 2 of 4
Lynda M. Stuart, Bill & Melinda Gates Foundation, USA
Sensing Bacterial Virulence

Friday, June 11 | 5:00PM - 7:15PM
Pathogen-Specific Responses
Room: Burke Theatre/Beckett Rooms

Speaker 3 of 4
Stefanie N. Vogel, University of Maryland, USA
Distinct Roles of Alternatively Activated Macrophages in the Host Response to Bacterial and Viral Infection

Friday, June 11 | 5:00PM - 7:15PM
Pathogen-Specific Responses
Room: Burke Theatre/Beckett Rooms

Speaker 4 of 4
* Andrew G. Bowie, Trinity College Dublin, Ireland
Novel Components of Anti-Viral Pattern Recognition Receptor Pathways

Friday, June 11 | 7:15PM - 7:30PM
Closing Remarks
Room: Burke Theatre/Beckett Rooms

Speaker 1 of 1
Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Closing Remarks

Friday, June 11 | 7:30PM - 8:00PM
Social Hour
Room: Grand Dining Hall


Friday, June 11 | 7:30PM - 9:00PM
Entertainment
Room: Grand Dining Hall


Friday, June 11 | 8:00PM - 9:00PM
Cash Bar
Room: Grand Dining Hall


Friday, June 11 | 8:00PM - 9:00PM
Dinner
Room: Grand Dining Hall


Saturday, June 12 | 10:22AM - 10:22AM
Departure


*Session Chair
†Invited, not yet responded.