Web Desc
Cilia, Signaling and Human Disease
Organizer(s): Peter Jackson and Tim Stearns
Date: February 21 - 26, 2010
Location: Portola Hotel & Spa, Monterey, CA, USA
Supported by The Directors' Fund
Summary of Meeting:
Proteins mediating a host of signaling pathways are organized within primary cilia. Human genetic studies have identified many developmental and degenerative diseases linked to ciliary function. These “ciliopathies” include retinal degeneration, sensory and neurological deficiencies, polycystic kidney disease, and obesity. Molecular genetic studies have connected ciliary transport and assembly mechanisms to developmental pathways, including the Hedgehog pathway, and signaling pathways, including GPCR regulators, but much remains unclear. This meeting will focus on how signaling is organized within cilia. Presentations will span signaling, the cell biology of cilia, human and molecular genetics of ciliopathies, and the biology of ciliated tissues, including morphogen pathways, tissue repair, and links to cell cycle or tumor suppressor control. Drawing on broad expertise and multiple systems, we hope to discuss both well-validated and candidate ciliary genes. The goal is to better define pathways coordinating morphogenesis of ciliated tissue with ciliary assembly and signaling.
Scholarship Deadline: October 21 2009
Discounted Abstract Deadline: October 21 2009
Abstract Deadline: November 20 2009
Discounted Registration Deadline: December 21 2009
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Pubget Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 21 | 3:00PM - 7:30PM
Registration
Room: De Anza Foyer


Sunday, February 21 | 6:30PM - 7:30PM
Refreshments
Room: De Anza I-II


Monday, February 22 | 7:00AM - 8:00AM
Breakfast
Room: De Anza I-II


Monday, February 22 | 8:00AM - 11:00AM
Cell Biology of Cilia and Intraflagellar Transport
Room: De Anza III

Speaker 1 of 6
* Tim Stearns, Stanford University, USA

Monday, February 22 | 8:00AM - 11:00AM
Cell Biology of Cilia and Intraflagellar Transport
Room: De Anza III

Speaker 2 of 6
Joel Rosenbaum, Yale University, USA
Role of IFT in trafficking of polypeptides to and from the ciliary membrane and axoneme

Monday, February 22 | 8:00AM - 11:00AM
Cell Biology of Cilia and Intraflagellar Transport
Room: De Anza III

Speaker 3 of 6
Jonathan Scholey, University of California, Davis, USA
Intraflagellar Transport Motors in C. elegans Neurons

Monday, February 22 | 8:00AM - 11:00AM
Cell Biology of Cilia and Intraflagellar Transport
Room: De Anza III

Speaker 4 of 6
George B. Witman, University of Massachusetts Medical School, USA
Chlamydomonas as a Model for Human Ciliopathies

Monday, February 22 | 8:00AM - 11:00AM
Cell Biology of Cilia and Intraflagellar Transport
Room: De Anza III

Speaker 5 of 6
Gregory J. Pazour, University of Massachusetts Medical School, USA
Trafficking Proteins to the Ciliary Membrane

Monday, February 22 | 8:00AM - 11:00AM
Cell Biology of Cilia and Intraflagellar Transport
Room: De Anza III

Speaker 6 of 6
Christopher J. Westlake, NCI-Frederick, USA
Short Talk: Building the Primary Cilium Membrane: Regulation of GEF Trafficking and Activity and a Rab11-Rab8 Cascade

Monday, February 22 | 9:20AM - 9:40AM
Coffee Break
Room: De Anza Foyer


Monday, February 22 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Monday, February 22 | 11:00AM - 1:00PM
Poster Setup
Room: De Anza I-II


Monday, February 22 | 1:00PM - 10:00PM
Poster Viewing
Room: De Anza I-II


Monday, February 22 | 4:30PM - 5:00PM
Coffee Available
Room: De Anza Foyer


Monday, February 22 | 5:00PM - 7:00PM
Bardet-Biedl Syndrome, Alstrom Syndrome, Obesity Syndromes
Room: De Anza III

Speaker 1 of 5
* Jonathan Scholey, University of California, Davis, USA

Monday, February 22 | 5:00PM - 7:00PM
Bardet-Biedl Syndrome, Alstrom Syndrome, Obesity Syndromes
Room: De Anza III

Speaker 2 of 5
Val C. Sheffield, University of Iowa, USA
Human Genetics, Function, and Physiology in Bardet-Biedl Syndrome

Monday, February 22 | 5:00PM - 7:00PM
Bardet-Biedl Syndrome, Alstrom Syndrome, Obesity Syndromes
Room: De Anza III

Speaker 3 of 5
Maxence V. Nachury, University of California, San Francisco, USA
The BBSome is a coat complex for trafficking to the cilium / Discovery and characterization of tubulin acetyl-transferase

Monday, February 22 | 5:00PM - 7:00PM
Bardet-Biedl Syndrome, Alstrom Syndrome, Obesity Syndromes
Room: De Anza III

Speaker 4 of 5
Juergen K. Naggert, The Jackson Laboratory, USA
Alstrom Syndrome, a Ciliopathy

Monday, February 22 | 5:00PM - 7:00PM
Bardet-Biedl Syndrome, Alstrom Syndrome, Obesity Syndromes
Room: De Anza III

Speaker 5 of 5
Wallace Marshall, University of California, San Francisco, USA
Short Talk: The Flagellar Length Control System

Monday, February 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: De Anza Foyer


Monday, February 22 | 7:30PM - 10:00PM
Poster Session 1
Room: De Anza I-II


Tuesday, February 23 | 7:00AM - 8:00AM
Breakfast
Room: De Anza I-II


Tuesday, February 23 | 8:00AM - 11:15AM
Morphogen Pathways and Cilia
Room: De Anza III

Speaker 1 of 7
* John Wallingford, University of Texas at Austin, USA

Tuesday, February 23 | 8:00AM - 11:15AM
Morphogen Pathways and Cilia
Room: De Anza III

Speaker 2 of 7
Matthew P. Scott, Stanford University, USA
Hedgehog Signaling: Tracking Down Smo

Tuesday, February 23 | 8:00AM - 11:15AM
Morphogen Pathways and Cilia
Room: De Anza III

Speaker 3 of 7
Andrew P. McMahon, Harvard University, USA
Defective Hedgehog Signaling

Tuesday, February 23 | 8:00AM - 11:15AM
Morphogen Pathways and Cilia
Room: De Anza III

Speaker 4 of 7
H. Joseph Joseph Yost, University of Utah, USA
FGF Signaling Pathways and Heparan Sulfate Proteoglycan Fine Structures Converge at Cilia in the Development of Diverse Epithelia

Tuesday, February 23 | 8:00AM - 11:15AM
Morphogen Pathways and Cilia
Room: De Anza III

Speaker 5 of 7
Martin Blum, University of Hohenheim, Germany
Short Talk: The Nodal Inhibitor Coco Represents the Critical Target of Leftward Flow in Xenopus

Tuesday, February 23 | 8:00AM - 11:15AM
Morphogen Pathways and Cilia
Room: De Anza III

Speaker 6 of 7
Ivan P. Moskowitz, University of Chicago, USA
Short Talk: An Allelic Series of Intraflagellar Transport Protein 172 Implicates a Quantitative Loss of Hedgehog Signaling in VACTERL with Hydrocephalus

Tuesday, February 23 | 8:00AM - 11:15AM
Morphogen Pathways and Cilia
Room: De Anza III

Speaker 7 of 7
Jeremy F. Reiter, University of California, San Francisco, USA
Ofd1, a Ciliopathy Gene, Regulates the Length and Distal Structure of Centrioles

Tuesday, February 23 | 9:20AM - 9:40AM
Coffee Break
Room: De Anza Foyer


Tuesday, February 23 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, February 23 | 11:15AM - 1:00PM
Poster Setup
Room: De Anza I-II


Tuesday, February 23 | 1:00PM - 10:00PM
Poster Viewing
Room: De Anza I-II


Tuesday, February 23 | 4:30PM - 5:00PM
Coffee Available
Room: De Anza Foyer


Tuesday, February 23 | 5:00PM - 7:00PM
Neural Development
Room: De Anza III

Speaker 1 of 5
* Matthew P. Scott, Stanford University, USA

Tuesday, February 23 | 5:00PM - 7:00PM
Neural Development
Room: De Anza III

Speaker 2 of 5
Kathryn V. Anderson, Memorial Sloan-Kettering Cancer Center, USA
Trafficking in Primary Cilia and Hedgehog Signaling

Tuesday, February 23 | 5:00PM - 7:00PM
Neural Development
Room: De Anza III

Speaker 3 of 5
Joseph G. Gleeson, HHMI/The Rockefeller University, USA
Uncovering New Signaling Mechanisms in the Ciliopathy Disorders

Tuesday, February 23 | 5:00PM - 7:00PM
Neural Development
Room: De Anza III

Speaker 4 of 5
Jonathan T. Eggenschwiler, Princeton University, USA
Short Talk: Broad-Minded Links Ciliary Assembly, Cell Cycle-Related Kinase Function, and Mammalian Hedgehog Signaling

Tuesday, February 23 | 5:00PM - 7:00PM
Neural Development
Room: De Anza III

Speaker 5 of 5
Chris R. Kintner, The Salk Institute, USA
Developmental Mechanisms Specifying Different Cilia Subtypes

Tuesday, February 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: De Anza Foyer


Tuesday, February 23 | 7:30PM - 10:00PM
Poster Session 2
Room: De Anza I-II


Wednesday, February 24 | 7:00AM - 8:00AM
Breakfast
Room: De Anza I-II


Wednesday, February 24 | 8:00AM - 11:15AM
Sensory Events and Cilia
Room: De Anza III

Speaker 1 of 7
* Jeremy F. Reiter, University of California, San Francisco, USA

Wednesday, February 24 | 8:00AM - 11:15AM
Sensory Events and Cilia
Room: De Anza III

Speaker 2 of 7
Piali Sengupta, Brandeis University, USA
Generation and Maintenance of Specialized Sensory Cilia in C. elegans

Wednesday, February 24 | 8:00AM - 11:15AM
Sensory Events and Cilia
Room: De Anza III

Speaker 3 of 7
Abigail Tadenev, Johns Hopkins School of Medicine, USA
Short Talk: Olfactory Phenotypes of BBS8-Null Mice

Wednesday, February 24 | 8:00AM - 11:15AM
Sensory Events and Cilia
Room: De Anza III

Speaker 4 of 7
Jagesh V. Shah, Harvard Medical School, USA
Short Talk: Identification of Signaling Pathways Regulating Primary Cilium Length and Flow-Mediated Adaptation

Wednesday, February 24 | 8:00AM - 11:15AM
Sensory Events and Cilia
Room: De Anza III

Speaker 5 of 7
Tomer Avidor-Reiss, Harvard Medical School, USA
Centriole and Cilia - Formation and Inheritance

Wednesday, February 24 | 8:00AM - 11:15AM
Sensory Events and Cilia
Room: De Anza III

Speaker 6 of 7
Brian D. Dynlacht, New York University School of Medicine, USA
CP110 and Control of the Centriole and Cilia Biogenesis

Wednesday, February 24 | 8:00AM - 11:15AM
Sensory Events and Cilia
Room: De Anza III

Speaker 7 of 7
John Wallingford, University of Texas at Austin, USA
Planar Cell Polarity and Ciliogenesis

Wednesday, February 24 | 9:20AM - 9:40AM
Coffee Break
Room: De Anza Foyer


Wednesday, February 24 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, February 24 | 4:30PM - 5:00PM
Coffee Available
Room: De Anza Foyer


Wednesday, February 24 | 5:00PM - 7:15PM
Kidneys, Cysts, and Cystic Diseases
Room: De Anza III

Speaker 1 of 6
* Brian D. Dynlacht, New York University School of Medicine, USA

Wednesday, February 24 | 5:00PM - 7:15PM
Kidneys, Cysts, and Cystic Diseases
Room: De Anza III

Speaker 2 of 6
Peter C. Harris, USA
Role of Cilia in ADPKD and ARPKD

Wednesday, February 24 | 5:00PM - 7:15PM
Kidneys, Cysts, and Cystic Diseases
Room: De Anza III

Speaker 3 of 6
Friedhelm Hildebrandt, Boston Children’s Hospital, Harvard Medical School, USA
Genes and Mechanisms of Nephronophthisis-Like Ciliopathies

Wednesday, February 24 | 5:00PM - 7:15PM
Kidneys, Cysts, and Cystic Diseases
Room: De Anza III

Speaker 4 of 6
Peter K. Jackson, Stanford University, USA
The NPHP-Joubert-Meckel-Gruber Network

Wednesday, February 24 | 5:00PM - 7:15PM
Kidneys, Cysts, and Cystic Diseases
Room: De Anza III

Speaker 5 of 6
Michel R. Leroux, Simon Fraser University, Canada
Short Talk: Ciliary Transition Zone Proteins are Required for Proper Basal Body Positioning, Structural Integrity of the Ciliary Gate, and Proper Formation of the Axoneme

Wednesday, February 24 | 5:00PM - 7:15PM
Kidneys, Cysts, and Cystic Diseases
Room: De Anza III

Speaker 6 of 6
Rebecca D. Burdine, Princeton University, USA
Short Talk: Seahorse and Kurly are Members of a Cytoplasmic Complex that Functions in Cilia Motility and Downstream Phenotypes

Wednesday, February 24 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: De Anza Foyer


Thursday, February 25 | 7:00AM - 8:00AM
Breakfast
Room: De Anza I-II


Thursday, February 25 | 8:00AM - 11:00AM
Cell Cycle, Tumor Suppressors, and Cancer
Room: De Anza III

Speaker 1 of 6
* Peter K. Jackson, Stanford University, USA

Thursday, February 25 | 8:00AM - 11:00AM
Cell Cycle, Tumor Suppressors, and Cancer
Room: De Anza III

Speaker 2 of 6
Elizabeth Petri Henske, Brigham and Women's Hospital, USA
Tuberous Sclerosis, LAM, and the Primary Cilium: Where are the Links?

Thursday, February 25 | 8:00AM - 11:00AM
Cell Cycle, Tumor Suppressors, and Cancer
Room: De Anza III

Speaker 3 of 6
James G. Umen, Donald Danforth Plant Science Center, USA
Short Talk: A Cyclin Dependent Kinase Mutant from Chlamydomonas Reveals a Conserved Role for the Retinoblastoma Tumor Suppressor Pathway in Cilia Biogenesis

Thursday, February 25 | 8:00AM - 11:00AM
Cell Cycle, Tumor Suppressors, and Cancer
Room: De Anza III

Speaker 4 of 6
Wilhelm Krek, Institute of Molecular Health Sciences, ETH Zürich, Switzerland
VHL Tumor Suppression Mechanisms: From Maintenance of the Primary Cilium to Promotion of Error-free Mitosis

Thursday, February 25 | 8:00AM - 11:00AM
Cell Cycle, Tumor Suppressors, and Cancer
Room: De Anza III

Speaker 5 of 6
Benedicte Delaval, USA
The Cilia Protein IFT88 Forms Novel Mitotic Complexes and Functions in Spindle Pole Organization and the Orientation of the Mitotic Spindle and the Plane of Cell Division

Thursday, February 25 | 8:00AM - 11:00AM
Cell Cycle, Tumor Suppressors, and Cancer
Room: De Anza III

Speaker 6 of 6
Tim Stearns, Stanford University, USA
From Microarrays to Cell Biology

Thursday, February 25 | 9:20AM - 9:40AM
Coffee Break
Room: De Anza Foyer


Thursday, February 25 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Thursday, February 25 | 2:30PM - 4:30PM
Workshop: Short Talk Symposium
Room: De Anza III

Speaker 1 of 8
* Peter K. Jackson, Stanford University, USA

Thursday, February 25 | 2:30PM - 4:30PM
Workshop: Short Talk Symposium
Room: De Anza III

Speaker 2 of 8
* Tim Stearns, Stanford University, USA

Thursday, February 25 | 2:30PM - 4:30PM
Workshop: Short Talk Symposium
Room: De Anza III

Speaker 3 of 8
Cosima T. Baldari, University of Siena, Italy
Intraflagellar Transport is Required for Polarized Recycling of the TCR/CD3 Complex to the Immune Synapse

Thursday, February 25 | 2:30PM - 4:30PM
Workshop: Short Talk Symposium
Room: De Anza III

Speaker 4 of 8
Saikat Mukhopadhyay, University of Texas Southwestern Medical Center, USA
'A Short Story of a Known Complex and an Unkown Cargo'

Thursday, February 25 | 2:30PM - 4:30PM
Workshop: Short Talk Symposium
Room: De Anza III

Speaker 5 of 8
Heather H. Ward, University of Washington- Seattle, USA
A Multimeric GTPase Complex is Required for Trafficking Membrane Cystoproteins to Primary Cilia

Thursday, February 25 | 2:30PM - 4:30PM
Workshop: Short Talk Symposium
Room: De Anza III

Speaker 6 of 8
Marina Bershteyn, University of California, San Francisco, USA
MIM and Cortactin Antagonism Regulates Ciliogenesis and Hedgehog Signaling

Thursday, February 25 | 2:30PM - 4:30PM
Workshop: Short Talk Symposium
Room: De Anza III

Speaker 7 of 8
Sander Basten, University Medical Center Utrecht, Netherlands
Ciliary Gene LRRC50 and Tumorigenesis

Thursday, February 25 | 2:30PM - 4:30PM
Workshop: Short Talk Symposium
Room: De Anza III

Speaker 8 of 8
Peter G. Czarnecki, Beth Israel Deconess Medical Center, USA
Meckel-Gruber Syndrome Proteins MKS1 and MKS3 in Ciliary Homeostasis and Wnt Signaling

Thursday, February 25 | 4:30PM - 5:00PM
Coffee Available
Room: De Anza Foyer


Thursday, February 25 | 5:00PM - 7:00PM
Cilia, Evolution, and Human Disease
Room: De Anza III

Speaker 1 of 5
* Anthony Oro, Stanford University, USA

Thursday, February 25 | 5:00PM - 7:00PM
Cilia, Evolution, and Human Disease
Room: De Anza III

Speaker 2 of 5
Arturo Alvarez-Buylla, University of California, San Francisco, USA
Primary Cilia in Neural Stem Cells and Cancer

Thursday, February 25 | 5:00PM - 7:00PM
Cilia, Evolution, and Human Disease
Room: De Anza III

Speaker 3 of 5
Mónica Bettencourt Dias, Instituto Gulbenkian de Ciência, Portugal
Centriole Biogenesis and Evolution

Thursday, February 25 | 5:00PM - 7:00PM
Cilia, Evolution, and Human Disease
Room: De Anza III

Speaker 4 of 5
Bill Wickstead, University of Nottingham, UK
Short Talk: Reconstructing the Evolutionary History of the Centriole from Protein Components

Thursday, February 25 | 5:00PM - 7:00PM
Cilia, Evolution, and Human Disease
Room: De Anza III

Speaker 5 of 5
Nicholas Katsanis, Northwestern University Feinberg School of Medicine, USA
Total Mutational Load and Ciliary Disease

Thursday, February 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: De Anza Foyer


Thursday, February 25 | 8:00PM - 11:00PM
Entertainment
Room: De Anza I-II


Thursday, February 25 | 8:00PM - 11:00PM
Cash Bar
Room: De Anza I-II


Friday, February 26 | 10:25AM - 10:25AM
Departure


*Session Chair.