Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Frontiers of Structural Biology (2014Z2)
High-Throughput Structural Biology (2012J5)

Web Desc
Structural Genomics: Expanding the Horizons of Structural Biology joint with Structural Biology Organizer(s): Ian A. Wilson, Kurt Wüthrich, Soichi Wakatsuki and Christine A. Orengo Date: January 08 - 13, 2010 Location: Beaver Run Resort, Breckenridge, CO, USA Supported by The Directors' Fund For important information on the coronavirus, please click here Summary of Meeting: Structural Biology continues to be one of the most prolific and informative ways to make biological and biomedical discoveries at the turn of the millennium, and provides fundamental molecular level insights into the underlying biological and biochemical functions. Structural genomics has been at the forefront of these developments as a major contributor to the advances of high throughput (HT) technologies and methodologies that span the gene to structure process by both crystallography and NMR. In parallel, the rapid expansion of the genome sequencing projects is substantially increasing the complexity and size of the known protein universe, and providing structural biologists with a wealth of new opportunities and challenges to explore, the diversity of biological macromolecules and their relationships to, function, evolution and disease. The goal of this Keystone Symposia meeting is to explore how we can best harness the current approaches from high throughput structural genomics to tackle present and future challenges in structural biology and how we can directly apply these methods to topical and important problems in structural, molecular, cellular and chemical biology. We will focus on approaches that are applicable not only for large consortia, but also for single investigator laboratories and smaller scale projects. Using such methodologies and technologies, we can then keep pace with the genome sequencing efforts and continue to make significant contributions to the constantly increasing discoveries on the intricacies and vagaries of complex biological processes – such as mammalian proteomes, microbial pathogens and cellular and signaling networks / systems. In this way, structural biology will continue to lead the way in making innovative discoveries in biological, chemical, and biomedical research. Scholarship Deadline: September 14 2009 Discounted Abstract Deadline: September 14 2009 Abstract Deadline: October 12 2009 Discounted Registration Deadline: November 9 2009 We gratefully acknowledge additional support for this conference from: Suraj Manrao, Student Travel Fund Corrado Spadafora We gratefully acknowledge the generous grant for this conference provided by: National Institute of General Medical Sciences (NIGMS) Grant No. 1R13GM088949-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Structural Genomics: Expanding the Horizons of Structural Biology

joint with Structural Biology

Organizer(s): Ian A. Wilson, Kurt Wüthrich, Soichi Wakatsuki and Christine A. Orengo

Date: January 08 - 13, 2010
Location: Beaver Run Resort, Breckenridge, CO, USA

Supported by The Directors' Fund

For important information on the coronavirus, please click here

Summary of Meeting:

Structural Biology continues to be one of the most prolific and informative ways to make biological and biomedical discoveries at the turn of the millennium, and provides fundamental molecular level insights into the underlying biological and biochemical functions. Structural genomics has been at the forefront of these developments as a major contributor to the advances of high throughput (HT) technologies and methodologies that span the gene to structure process by both crystallography and NMR. In parallel, the rapid expansion of the genome sequencing projects is substantially increasing the complexity and size of the known protein universe, and providing structural biologists with a wealth of new opportunities and challenges to explore, the diversity of biological macromolecules and their relationships to, function, evolution and disease. The goal of this Keystone Symposia meeting is to explore how we can best harness the current approaches from high throughput structural genomics to tackle present and future challenges in structural biology and how we can directly apply these methods to topical and important problems in structural, molecular, cellular and chemical biology. We will focus on approaches that are applicable not only for large consortia, but also for single investigator laboratories and smaller scale projects. Using such methodologies and technologies, we can then keep pace with the genome sequencing efforts and continue to make significant contributions to the constantly increasing discoveries on the intricacies and vagaries of complex biological processes – such as mammalian proteomes, microbial pathogens and cellular and signaling networks / systems. In this way, structural biology will continue to lead the way in making innovative discoveries in biological, chemical, and biomedical research.

Scholarship Deadline: September 14 2009

Discounted Abstract Deadline: September 14 2009

Abstract Deadline: October 12 2009

Discounted Registration Deadline: November 9 2009

We gratefully acknowledge additional support for this conference from:

Suraj Manrao, Student Travel Fund

Corrado Spadafora

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM088949-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Friday, January 08 \| 3:00PM - 7:30PM Registration Room: Foyer
Friday, January 08 \| 6:15PM - 7:15PM Refreshments Room: Foyer
Friday, January 08 \| 7:15PM - 7:30PM Orientation for New Attendees and New Investigators Room: Peaks 1-5 Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a 'What to Expect during your Attendance' for interested delegates.
Friday, January 08 \| 7:30PM - 8:30PM Keynote Session (Joint) Room: Peaks 1-5 Speaker 1 of 3 * Alasdair C. Steven, NIAMS, National Institutes of Health, USA
Friday, January 08 \| 7:30PM - 8:30PM Keynote Session (Joint) Room: Peaks 1-5 Speaker 2 of 3 * Ian A. Wilson, The Scripps Research Institute, USA
Friday, January 08 \| 7:30PM - 8:30PM Keynote Session (Joint) Room: Peaks 1-5 Speaker 3 of 3 William E. Moerner, Stanford University, USA Single-Molecule Approaches to Biomolecular Dynamics and Imaging of Cellular Superstructures
Saturday, January 09 \| 7:00AM - 8:00AM Breakfast Room: Summit Gallery
Saturday, January 09 \| 8:00AM - 11:15AM Pushing the Limits of Structural Biology I: New and Innovati ve Methods (Joint) Room: Peaks 1-5 Speaker 1 of 7 * Kurt Wüthrich, ETH Zürich, Switzerland
Saturday, January 09 \| 8:00AM - 11:15AM Pushing the Limits of Structural Biology I: New and Innovati ve Methods (Joint) Room: Peaks 1-5 Speaker 2 of 7 Andrej Sali, University of California, San Francisco, USA Integrative Determination of Macromolecular Structures
Saturday, January 09 \| 8:00AM - 11:15AM Pushing the Limits of Structural Biology I: New and Innovati ve Methods (Joint) Room: Peaks 1-5 Speaker 3 of 7 John A. Tainer, The Scripps Research Institute, USA Short Talk: Proteomics Scale X-ray Solution Scattering (SAXS) to Shape Interactomes
Saturday, January 09 \| 8:00AM - 11:15AM Pushing the Limits of Structural Biology I: New and Innovati ve Methods (Joint) Room: Peaks 1-5 Speaker 4 of 7 Ad Bax, NIDDK, National Institutes of Health, USA Combining Novel Solution NMR Approaches with SAXS
Saturday, January 09 \| 8:00AM - 11:15AM Pushing the Limits of Structural Biology I: New and Innovati ve Methods (Joint) Room: Peaks 1-5 Speaker 5 of 7 Wah Chiu, Baylor College of Medicine, USA Seeing Protein Backbone and Side-Chains in Molecular Machines by Cryo-EM
Saturday, January 09 \| 8:00AM - 11:15AM Pushing the Limits of Structural Biology I: New and Innovati ve Methods (Joint) Room: Peaks 1-5 Speaker 6 of 7 Daniel J. Müller, ETH Zurich, Switzerland Force Probing How Membrane Proteins Regulate Molecular Mechanics of Cell Rounding
Saturday, January 09 \| 8:00AM - 11:15AM Pushing the Limits of Structural Biology I: New and Innovati ve Methods (Joint) Room: Peaks 1-5 Speaker 7 of 7 Graham T. Johnson, University of California, San Francisco, USA Short Talk: Automated Visualization of Subcellular Environments
Saturday, January 09 \| 9:20AM - 9:40AM Coffee Break Room: Foyer
Saturday, January 09 \| 11:15AM - 1:00PM Poster Setup Room: Breckenridge Ballroom
Saturday, January 09 \| 11:15AM - 11:15AM On Own for Lunch and Recreation
Saturday, January 09 \| 1:00PM - 10:00PM Poster Viewing Room: Breckenridge Ballroom
Saturday, January 09 \| 2:30PM - 4:30PM Workshop 1: Advances in Methodologies and Tools for Structur al Biology Room: Peak 5 This workshop will focus on new methodologies, technologies, instrumentation, devices, software and innovations for production, characterization, structure determination and analysis of biological macromolecules, including servers, databases and repositories. Speaker 1 of 10 * Andrew May, Sana Biotechnology, Inc., USA
Saturday, January 09 \| 2:30PM - 4:30PM Workshop 1: Advances in Methodologies and Tools for Structur al Biology Room: Peak 5 This workshop will focus on new methodologies, technologies, instrumentation, devices, software and innovations for production, characterization, structure determination and analysis of biological macromolecules, including servers, databases and repositories. Speaker 2 of 10 * Helen M. Berman, Rutgers University, Center for Proteomics Research, USA
Saturday, January 09 \| 2:30PM - 4:30PM Workshop 1: Advances in Methodologies and Tools for Structur al Biology Room: Peak 5 This workshop will focus on new methodologies, technologies, instrumentation, devices, software and innovations for production, characterization, structure determination and analysis of biological macromolecules, including servers, databases and repositories. Speaker 3 of 10 George N. Phillips, Jr., University of Wisconsin, CESG, USA Use of a Cell-Free Protein Production Platform for X-Ray Crystallography
Saturday, January 09 \| 2:30PM - 4:30PM Workshop 1: Advances in Methodologies and Tools for Structur al Biology Room: Peak 5 This workshop will focus on new methodologies, technologies, instrumentation, devices, software and innovations for production, characterization, structure determination and analysis of biological macromolecules, including servers, databases and repositories. Speaker 4 of 10 Cory J. Gerdts, Protein BioSolutions, USA Nanovolume Optimization of Protein Crystal Growth Using the Microcapillary Protein Crystallization System
Saturday, January 09 \| 2:30PM - 4:30PM Workshop 1: Advances in Methodologies and Tools for Structur al Biology Room: Peak 5 This workshop will focus on new methodologies, technologies, instrumentation, devices, software and innovations for production, characterization, structure determination and analysis of biological macromolecules, including servers, databases and repositories. Speaker 5 of 10 Andrei Kouranov, Monsanto, USA PepcDB (Protein Expression Purification Crystallization DataBase): A Tool for Experimental Design
Saturday, January 09 \| 2:30PM - 4:30PM Workshop 1: Advances in Methodologies and Tools for Structur al Biology Room: Peak 5 This workshop will focus on new methodologies, technologies, instrumentation, devices, software and innovations for production, characterization, structure determination and analysis of biological macromolecules, including servers, databases and repositories. Speaker 6 of 10 Paolo Rossi, Rutgers University, USA Synergies of X-ray, NMR, and Rosetta in Protein Structure Determination
Saturday, January 09 \| 2:30PM - 4:30PM Workshop 1: Advances in Methodologies and Tools for Structur al Biology Room: Peak 5 This workshop will focus on new methodologies, technologies, instrumentation, devices, software and innovations for production, characterization, structure determination and analysis of biological macromolecules, including servers, databases and repositories. Speaker 7 of 10 Peter Minary, Stanford University, USA Conformational Optimization with Natural Degrees of Freedom: A Novel Stochastic Chain Closure Algorithm and its Applications
Saturday, January 09 \| 2:30PM - 4:30PM Workshop 1: Advances in Methodologies and Tools for Structur al Biology Room: Peak 5 This workshop will focus on new methodologies, technologies, instrumentation, devices, software and innovations for production, characterization, structure determination and analysis of biological macromolecules, including servers, databases and repositories. Speaker 8 of 10 Joshua M. Gilmore, Stowers Institute for Medical Research, USA Determining Protein Complex Architecture using a Probabilistic Deletion Network Derived from Quantitative Proteomics
Saturday, January 09 \| 2:30PM - 4:30PM Workshop 1: Advances in Methodologies and Tools for Structur al Biology Room: Peak 5 This workshop will focus on new methodologies, technologies, instrumentation, devices, software and innovations for production, characterization, structure determination and analysis of biological macromolecules, including servers, databases and repositories. Speaker 9 of 10 Gyorgy Babnigg, Argonne National Laboratory, USA Comparison of High-Throughput Techniques for the Expression of Protein Complexes
Saturday, January 09 \| 2:30PM - 4:30PM Workshop 1: Advances in Methodologies and Tools for Structur al Biology Room: Peak 5 This workshop will focus on new methodologies, technologies, instrumentation, devices, software and innovations for production, characterization, structure determination and analysis of biological macromolecules, including servers, databases and repositories. Speaker 10 of 10 Wladek Minor, University of Virginia, USA Application of the Ligand Screening Module in HKL-3000 for High-Throughput Identification of Bound Ligands in Protein Crystal Structures
Saturday, January 09 \| 4:30PM - 5:00PM Coffee Available Room: Foyer
Saturday, January 09 \| 5:00PM - 7:00PM Advances in Protein and Nucleic Acid Production and Crystall ization Room: Peak 5 Speaker 1 of 5 * Andrzej Joachimiak, Argonne National Laboratory, USA
Saturday, January 09 \| 5:00PM - 7:00PM Advances in Protein and Nucleic Acid Production and Crystall ization Room: Peak 5 Speaker 2 of 5 Scott A. Lesley, Genomics Institute of the Novartis Research Foundation, USA Applying Structural Genomics Principles to Biology-Centered Targets
Saturday, January 09 \| 5:00PM - 7:00PM Advances in Protein and Nucleic Acid Production and Crystall ization Room: Peak 5 Speaker 3 of 5 Yaeta Endo, Ehime University, Japan Advances in Cell Free Systems for Expression of Eukaryotic and Parasitic Proteins
Saturday, January 09 \| 5:00PM - 7:00PM Advances in Protein and Nucleic Acid Production and Crystall ization Room: Peak 5 Speaker 4 of 5 Robert T. Batey, University of Colorado, Boulder, USA Advances in Preparation and Crystallization of RNA
Saturday, January 09 \| 5:00PM - 7:00PM Advances in Protein and Nucleic Acid Production and Crystall ization Room: Peak 5 Speaker 5 of 5 Joseph R. Luft, Hauptman-Woodward Medical Research Institute, USA Short Talk: The Use of Empirically Derived Detergent Phase Boundaries to Crystallize Membrane Proteins
Saturday, January 09 \| 5:00PM - 7:00PM Macromolecular Complexes I This session is from Structural Biology Room: Peaks 1-4 Speaker 1 of 5 * Christopher P. Hill, University of Utah, USA
Saturday, January 09 \| 5:00PM - 7:00PM Macromolecular Complexes I This session is from Structural Biology Room: Peaks 1-4 Speaker 2 of 5 Eva Nogales, University of California, Berkeley, USA Microtubule-Kinetochore Interactions
Saturday, January 09 \| 5:00PM - 7:00PM Macromolecular Complexes I This session is from Structural Biology Room: Peaks 1-4 Speaker 3 of 5 Cynthia Wolberger, Johns Hopkins University School of Medicine, USA Insights into the Unusual Chemistry of Sir2 Enzymes
Saturday, January 09 \| 5:00PM - 7:00PM Macromolecular Complexes I This session is from Structural Biology Room: Peaks 1-4 Speaker 4 of 5 Justin L. P. Benesch, University of Oxford, UK Short Talk: A Hybrid Approach for Determining the Structures of Protein Oligomers Comprising Heterogeneous Ensembles
Saturday, January 09 \| 5:00PM - 7:00PM Macromolecular Complexes I This session is from Structural Biology Room: Peaks 1-4 Speaker 5 of 5 Angela M. Gronenborn, University of Pittsburgh, USA Synergy between cryo-EM and NMR - Novel Findings for HIV capsid Function
Saturday, January 09 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Breckenridge Ballroom
Saturday, January 09 \| 7:30PM - 10:00PM Poster Session 1 Room: Breckenridge Ballroom
Sunday, January 10 \| 7:00AM - 8:00AM Breakfast Room: Summit Gallery
Sunday, January 10 \| 8:00AM - 11:15AM Advances in Crystallography, Magnetic Resonance Spectroscopy and Computation Room: Peak 5 Speaker 1 of 7 * Robert M. Stroud, University of California, San Francisco, USA
Sunday, January 10 \| 8:00AM - 11:15AM Advances in Crystallography, Magnetic Resonance Spectroscopy and Computation Room: Peak 5 Speaker 2 of 7 Soichi Wakatsuki, Stanford University, USA Developments in Synchrotron Protein Crystallography for Targeted Structural Proteomics
Sunday, January 10 \| 8:00AM - 11:15AM Advances in Crystallography, Magnetic Resonance Spectroscopy and Computation Room: Peak 5 Speaker 3 of 7 Kurt Wüthrich, ETH Zürich, Switzerland NMR in Structural Genomics: New Strategic and Technical Challenges
Sunday, January 10 \| 8:00AM - 11:15AM Advances in Crystallography, Magnetic Resonance Spectroscopy and Computation Room: Peak 5 Speaker 4 of 7 John L. Markley, University of Wisconsin-Madison, USA Short Talk: Advances in High-Throughput NMR Spectroscopy of Proteins
Sunday, January 10 \| 8:00AM - 11:15AM Advances in Crystallography, Magnetic Resonance Spectroscopy and Computation Room: Peak 5 Speaker 5 of 7 Wayne A. Hendrickson, Columbia University, USA Structural Genomics of Membrane Proteins by X-ray Crystallography
Sunday, January 10 \| 8:00AM - 11:15AM Advances in Crystallography, Magnetic Resonance Spectroscopy and Computation Room: Peak 5 Speaker 6 of 7 David Baker, University of Washington, USA Rapid Structure Determination from Sparse Experimental Data Sets using Rosetta
Sunday, January 10 \| 8:00AM - 11:15AM Advances in Crystallography, Magnetic Resonance Spectroscopy and Computation Room: Peak 5 Speaker 7 of 7 Michael A. Kennedy, Miami University, USA Short Talk: EPR-Based Long-Range Distance Restraints for Structure Determination of Protein Complexes
Sunday, January 10 \| 8:00AM - 11:00AM Membrane-Associated Phenomena This session is from Structural Biology Room: Peaks 1-4 Speaker 1 of 6 * Hartmut Luecke, University of California, Irvine, USA
Sunday, January 10 \| 8:00AM - 11:00AM Membrane-Associated Phenomena This session is from Structural Biology Room: Peaks 1-4 Speaker 2 of 6 James H. Hurley, University of California, Berkeley, USA The ESCRT Complexes in Membrane Scission and Budding
Sunday, January 10 \| 8:00AM - 11:00AM Membrane-Associated Phenomena This session is from Structural Biology Room: Peaks 1-4 Speaker 3 of 6 Christopher P. Arthur, FEI Co., USA Short Talk: Structure of Botulinum Neurotoxin Serotype B in a Lipid Bilayer at Multiple pH Levels
Sunday, January 10 \| 8:00AM - 11:00AM Membrane-Associated Phenomena This session is from Structural Biology Room: Peaks 1-4 Speaker 4 of 6 Gabriel Waksman, Birkbeck College and University College London, UK Structural Biology of Type IV Secretion Systems
Sunday, January 10 \| 8:00AM - 11:00AM Membrane-Associated Phenomena This session is from Structural Biology Room: Peaks 1-4 Speaker 5 of 6 Mark S.P. Sansom, University of Oxford, UK Multiscale Simulations of Membrane Proteins
Sunday, January 10 \| 8:00AM - 11:00AM Membrane-Associated Phenomena This session is from Structural Biology Room: Peaks 1-4 Speaker 6 of 6 Jay T. Groves, University of California, Berkeley, USA Spatial and Mechanical Regulation of Signal Transduction in Cell Membranes
Sunday, January 10 \| 9:20AM - 9:40AM Coffee Break Room: Foyer
Sunday, January 10 \| 11:15AM - 1:00PM Poster Setup Room: Breckenridge Ballroom
Sunday, January 10 \| 11:15AM - 11:15AM On Own for Lunch and Recreation
Sunday, January 10 \| 1:00PM - 10:00PM Poster Viewing Room: Breckenridge Ballroom
Sunday, January 10 \| 2:30PM - 4:30PM Workshop 2: Structural Genomics and Functional Proteomics of Biological Macromolecules Room: Peak 5 This workshop will focus on novel insights gained from study of the expanding protein universe, protein families, individual organisms, microbiomes, metagenomes, drug targets, pathogens, novel mechanisms, challenging proteins, including RNA, protein-protein complexes, membrane proteins and eukaryotic proteins. Speaker 1 of 10 * Gaetano Thomas Montelione, Rutgers University, USA
Sunday, January 10 \| 2:30PM - 4:30PM Workshop 2: Structural Genomics and Functional Proteomics of Biological Macromolecules Room: Peak 5 This workshop will focus on novel insights gained from study of the expanding protein universe, protein families, individual organisms, microbiomes, metagenomes, drug targets, pathogens, novel mechanisms, challenging proteins, including RNA, protein-protein complexes, membrane proteins and eukaryotic proteins. Speaker 2 of 10 Marek Grabowski, University of Virginia, USA “Drugability” of Structural Genomics
Sunday, January 10 \| 2:30PM - 4:30PM Workshop 2: Structural Genomics and Functional Proteomics of Biological Macromolecules Room: Peak 5 This workshop will focus on novel insights gained from study of the expanding protein universe, protein families, individual organisms, microbiomes, metagenomes, drug targets, pathogens, novel mechanisms, challenging proteins, including RNA, protein-protein complexes, membrane proteins and eukaryotic proteins. Speaker 3 of 10 Parthasarathy Sampathkumar, Eli Lilly, USA Structures of Two PHR Domains from Mus musculus Phr1 (Mycbp2) Reveal a Novel Fold and Provide Insights into a C. elegans RPM-1 Loss of Function Mutation
Sunday, January 10 \| 2:30PM - 4:30PM Workshop 2: Structural Genomics and Functional Proteomics of Biological Macromolecules Room: Peak 5 This workshop will focus on novel insights gained from study of the expanding protein universe, protein families, individual organisms, microbiomes, metagenomes, drug targets, pathogens, novel mechanisms, challenging proteins, including RNA, protein-protein complexes, membrane proteins and eukaryotic proteins. Speaker 4 of 10 Werner Braun, University of Texas Medical Branch,, USA Allergen Structures in a Genomic Age
Sunday, January 10 \| 2:30PM - 4:30PM Workshop 2: Structural Genomics and Functional Proteomics of Biological Macromolecules Room: Peak 5 This workshop will focus on novel insights gained from study of the expanding protein universe, protein families, individual organisms, microbiomes, metagenomes, drug targets, pathogens, novel mechanisms, challenging proteins, including RNA, protein-protein complexes, membrane proteins and eukaryotic proteins. Speaker 5 of 10 Ashley M. Deacon, Stanford Synchrotron Radiation Laboratory, USA Structural and Functional Studies of the Bacterial Ancestors of Common Eukaryotic Protein Modules
Sunday, January 10 \| 2:30PM - 4:30PM Workshop 2: Structural Genomics and Functional Proteomics of Biological Macromolecules Room: Peak 5 This workshop will focus on novel insights gained from study of the expanding protein universe, protein families, individual organisms, microbiomes, metagenomes, drug targets, pathogens, novel mechanisms, challenging proteins, including RNA, protein-protein complexes, membrane proteins and eukaryotic proteins. Speaker 6 of 10 Liskin Swint-Kruse, University of Kansas Medical School, USA Comparing the Functional Roles of Nonconserved Sequence Positions in Homologous Transcription Repressors: Implications for Sequence/Function Analyses
Sunday, January 10 \| 2:30PM - 4:30PM Workshop 2: Structural Genomics and Functional Proteomics of Biological Macromolecules Room: Peak 5 This workshop will focus on novel insights gained from study of the expanding protein universe, protein families, individual organisms, microbiomes, metagenomes, drug targets, pathogens, novel mechanisms, challenging proteins, including RNA, protein-protein complexes, membrane proteins and eukaryotic proteins. Speaker 7 of 10 András Fiser, Albert Einstein College of Medicine, USA Structural Characteristics of Novel Protein Folds
Sunday, January 10 \| 2:30PM - 4:30PM Workshop 2: Structural Genomics and Functional Proteomics of Biological Macromolecules Room: Peak 5 This workshop will focus on novel insights gained from study of the expanding protein universe, protein families, individual organisms, microbiomes, metagenomes, drug targets, pathogens, novel mechanisms, challenging proteins, including RNA, protein-protein complexes, membrane proteins and eukaryotic proteins. Speaker 8 of 10 Markus Fischer, Columbia University, USA MarkUs: A Server to Navigate Sequence-Structure-Function Space
Sunday, January 10 \| 2:30PM - 4:30PM Workshop 2: Structural Genomics and Functional Proteomics of Biological Macromolecules Room: Peak 5 This workshop will focus on novel insights gained from study of the expanding protein universe, protein families, individual organisms, microbiomes, metagenomes, drug targets, pathogens, novel mechanisms, challenging proteins, including RNA, protein-protein complexes, membrane proteins and eukaryotic proteins. Speaker 9 of 10 Margaret J. Gabanyi, PSI Structural Biology Knowledgebase - Rutgers University, USA The PSI Structural Genomics Knowledgebase Technology Portal - an Online Resource for all Structural Biologists
Sunday, January 10 \| 2:30PM - 4:30PM Workshop 2: Structural Genomics and Functional Proteomics of Biological Macromolecules Room: Peak 5 This workshop will focus on novel insights gained from study of the expanding protein universe, protein families, individual organisms, microbiomes, metagenomes, drug targets, pathogens, novel mechanisms, challenging proteins, including RNA, protein-protein complexes, membrane proteins and eukaryotic proteins. Speaker 10 of 10 Andrew B. Ward, The Scripps Research Institute, USA Structural Basis of Drug Binding and Transport in P-glycoprotein
Sunday, January 10 \| 2:30PM - 4:30PM Special Session This session is from Structural Biology Room: Peaks 1-4 Speaker 1 of 6 * Alasdair C. Steven, NIAMS, National Institutes of Health, USA
Sunday, January 10 \| 2:30PM - 4:30PM Special Session This session is from Structural Biology Room: Peaks 1-4 Speaker 2 of 6 Vitold E. Galkin, University of Virginia, USA Short Talk: High Resolution Structures of F-actin Yield New Insights into the Dynamics of Actin Filament
Sunday, January 10 \| 2:30PM - 4:30PM Special Session This session is from Structural Biology Room: Peaks 1-4 Speaker 3 of 6 Christian Biertuempfel, Max Planck Institute of Biochemistry, Germany Short Talk: Crystal Structure of T4 Endonuclease VII Resolving a Holliday Junction
Sunday, January 10 \| 2:30PM - 4:30PM Special Session This session is from Structural Biology Room: Peaks 1-4 Speaker 4 of 6 Pingwei Li, Texas A&M University, USA Short Talk: The Structural Basis of Viral RNA Recognition by RIG-I
Sunday, January 10 \| 2:30PM - 4:30PM Special Session This session is from Structural Biology Room: Peaks 1-4 Speaker 5 of 6 Mei-ting Wu, University of Washington, USA Short Talk: Nanobodies were Crucial for Solving Crystal Structures from a Key Protein of an RNA-Editing Complex from the Sleeping Sickness Parasite Trypanosoma brucei
Sunday, January 10 \| 2:30PM - 4:30PM Special Session This session is from Structural Biology Room: Peaks 1-4 Speaker 6 of 6 Donald L.D. Caspar, Florida State University, USA Special Lecture: Origins of Structural Biology and Trials and Errors in its History
Sunday, January 10 \| 4:30PM - 5:00PM Coffee Available Room: Foyer
Sunday, January 10 \| 5:00PM - 7:00PM Challenging Proteins Room: Peak 5 Speaker 1 of 4 Robert M. Stroud, University of California, San Francisco, USA Ratiocinative Screen of Eukaryotic Integral Membrane Protein Expression and Solubilization for Structure Determination
Sunday, January 10 \| 5:00PM - 7:00PM Challenging Proteins Room: Peak 5 Speaker 2 of 4 Raymond Stevens, ShanghaiTech University and University of Southern California, USA Structure-Function of the Human G-Protein Coupled Receptor Family
Sunday, January 10 \| 5:00PM - 7:00PM Challenging Proteins Room: Peak 5 Speaker 3 of 4 Aled M. Edwards, University of Toronto, Canada Advances in Structural Proteomics of Human Proteins
Sunday, January 10 \| 5:00PM - 7:00PM Challenging Proteins Room: Peak 5 Speaker 4 of 4 Boguslaw Nocek, Argonne National Laboratory, USA Short Talk: Structure of the HK97-like Bacteriophage DNA Packaging Portal
Sunday, January 10 \| 5:00PM - 7:10PM Unfolded, Alternatively Folded, and Deliberately Folded Prot eins This session is from Structural Biology Room: Peaks 1-4 Speaker 1 of 5 * Mark R. Walter, University of Alabama, Birmingham, USA
Sunday, January 10 \| 5:00PM - 7:10PM Unfolded, Alternatively Folded, and Deliberately Folded Prot eins This session is from Structural Biology Room: Peaks 1-4 Speaker 2 of 5 Joel L. Sussman, Weizmann Institute of Science, Israel Intrinsically Disordered Proteins (IDPs): A Role in Nervous System Development
Sunday, January 10 \| 5:00PM - 7:10PM Unfolded, Alternatively Folded, and Deliberately Folded Prot eins This session is from Structural Biology Room: Peaks 1-4 Speaker 3 of 5 Alasdair C. Steven, NIAMS, National Institutes of Health, USA Amyloid Polymorphisms from Cryo-Electron Microscopy
Sunday, January 10 \| 5:00PM - 7:10PM Unfolded, Alternatively Folded, and Deliberately Folded Prot eins This session is from Structural Biology Room: Peaks 1-4 Speaker 4 of 5 Beat H. Meier, ETH Zürich, Switzerland Amyloid and Prion Structure by Solid-State NMR: What Can We Learn?
Sunday, January 10 \| 5:00PM - 7:10PM Unfolded, Alternatively Folded, and Deliberately Folded Prot eins This session is from Structural Biology Room: Peaks 1-4 Speaker 5 of 5 Dorothee Kern, Brandeis University, HHMI, USA Panorama of a Signaling Protein: Excursions in silico and in proteo
Sunday, January 10 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Breckenridge Ballroom
Sunday, January 10 \| 7:30PM - 10:00PM Poster Session 2 Room: Breckenridge Ballroom
Monday, January 11 \| 7:00AM - 8:00AM Breakfast Room: Summit Gallery
Monday, January 11 \| 8:00AM - 11:15AM Pushing the Limits of Structural Biology II: Advances in Cha llenging Systems (Joint) Room: Peaks 1-5 Speaker 1 of 7 * Pamela J. Bjorkman, California Institute of Technology, USA
Monday, January 11 \| 8:00AM - 11:15AM Pushing the Limits of Structural Biology II: Advances in Cha llenging Systems (Joint) Room: Peaks 1-5 Speaker 2 of 7 Steven C. Almo, Albert Einstein College of Medicine, USA Sequence, Structure, Function, Immunity
Monday, January 11 \| 8:00AM - 11:15AM Pushing the Limits of Structural Biology II: Advances in Cha llenging Systems (Joint) Room: Peaks 1-5 Speaker 3 of 7 Roger W. Hendrix, University of Pittsburgh, USA The Virome and Evolutionary Relationships
Monday, January 11 \| 8:00AM - 11:15AM Pushing the Limits of Structural Biology II: Advances in Cha llenging Systems (Joint) Room: Peaks 1-5 Speaker 4 of 7 Andrew B. Ward, The Scripps Research Institute, USA
Monday, January 11 \| 8:00AM - 11:15AM Pushing the Limits of Structural Biology II: Advances in Cha llenging Systems (Joint) Room: Peaks 1-5 Speaker 5 of 7 Thomas Güttler, Max Planck Institute for Biophysical Chemistry, Germany Short Talk: Cargo Recognition by the Nuclear Export Receptor CRM1/Exportin1
Monday, January 11 \| 8:00AM - 11:15AM Pushing the Limits of Structural Biology II: Advances in Cha llenging Systems (Joint) Room: Peaks 1-5 Speaker 6 of 7 Erik W. Debler, Rockefeller University, USA Short Talk: Characterization of the Nup84 Complex - Paradigm for the Nuclear Pore Complex Structure
Monday, January 11 \| 8:00AM - 11:15AM Pushing the Limits of Structural Biology II: Advances in Cha llenging Systems (Joint) Room: Peaks 1-5 Speaker 7 of 7 Jamie H.D. Cate, University of California, Berkeley, USA Structures of the Bacterial Ribosome and the Mechanism of Translocation
Monday, January 11 \| 9:20AM - 9:40AM Coffee Break Room: Foyer
Monday, January 11 \| 11:15AM - 1:00PM Poster Setup Room: Breckenridge Ballroom
Monday, January 11 \| 11:15AM - 11:15AM On Own for Lunch and Recreation
Monday, January 11 \| 1:00PM - 10:00PM Poster Viewing Room: Breckenridge Ballroom
Monday, January 11 \| 4:30PM - 5:00PM Coffee Available Room: Foyer
Monday, January 11 \| 5:00PM - 6:30PM Evolution of Structure and Function Room: Peak 5 Speaker 1 of 4 * Christine A. Orengo, University College London, UK
Monday, January 11 \| 5:00PM - 6:30PM Evolution of Structure and Function Room: Peak 5 Speaker 2 of 4 Ian A. Wilson, The Scripps Research Institute, USA What have we Learned from Structural Genomics of Proteins of Unknown Function?
Monday, January 11 \| 5:00PM - 6:30PM Evolution of Structure and Function Room: Peak 5 Speaker 3 of 4 Michael Levitt, Stanford University, USA The Protein Universe: A Current Snapshot
Monday, January 11 \| 5:00PM - 6:30PM Evolution of Structure and Function Room: Peak 5 Speaker 4 of 4 Barry Honig, Columbia University / HHMI, USA Structural and Functional Relationships between Proteins with Different Global Topologies: Implications for Function Annotation Strategies
Monday, January 11 \| 5:00PM - 7:00PM Structural Biology of Prokaryotic Cells This session is from Structural Biology Room: Peaks 1-4 Speaker 1 of 5 * Elizabeth J. Goldsmith, University of Texas Southwestern Medical Center Dallas, USA
Monday, January 11 \| 5:00PM - 7:00PM Structural Biology of Prokaryotic Cells This session is from Structural Biology Room: Peaks 1-4 Speaker 2 of 5 Natalie Strynadka, University of British Columbia, Canada Piecing Together the Type III Secretion System of Pathogenic Bacteria
Monday, January 11 \| 5:00PM - 7:00PM Structural Biology of Prokaryotic Cells This session is from Structural Biology Room: Peaks 1-4 Speaker 3 of 5 Grant J. Jensen, California Institute of Technology, USA Bacterial Cryotomography
Monday, January 11 \| 5:00PM - 7:00PM Structural Biology of Prokaryotic Cells This session is from Structural Biology Room: Peaks 1-4 Speaker 4 of 5 Clara L. Kielkopf, University of Rochester Center for RNA Biology, USA Short Talk: Structural Mechanism of Prokaryotic NADH/NAD+ Redox Sensing
Monday, January 11 \| 5:00PM - 7:00PM Structural Biology of Prokaryotic Cells This session is from Structural Biology Room: Peaks 1-4 Speaker 5 of 5 Ohad Medalia, Zurich University, Switzerland Structural Insight into the Nuclear Pore Complex by Cryo-Electron Tomography
Monday, January 11 \| 6:30PM - 7:15PM Debate 1: Protein Folds: Fact or Fiction?? Speaker 1 of 8 * Ian A. Wilson, The Scripps Research Institute, USA
Monday, January 11 \| 6:30PM - 7:15PM Debate 1: Protein Folds: Fact or Fiction?? Speaker 2 of 8 Barry Honig, Columbia University / HHMI, USA
Monday, January 11 \| 6:30PM - 7:15PM Debate 1: Protein Folds: Fact or Fiction?? Speaker 3 of 8 Joel L. Sussman, Weizmann Institute of Science, Israel
Monday, January 11 \| 6:30PM - 7:15PM Debate 1: Protein Folds: Fact or Fiction?? Speaker 4 of 8 Andrej Sali, University of California, San Francisco, USA
Monday, January 11 \| 6:30PM - 7:15PM Debate 1: Protein Folds: Fact or Fiction?? Speaker 5 of 8 Michael Levitt, Stanford University, USA
Monday, January 11 \| 6:30PM - 7:15PM Debate 1: Protein Folds: Fact or Fiction?? Speaker 6 of 8 Adam Godzik, Sanford-Burnham Medical Research Institute, USA
Monday, January 11 \| 6:30PM - 7:15PM Debate 1: Protein Folds: Fact or Fiction?? Speaker 7 of 8 David Baker, University of Washington, USA
Monday, January 11 \| 6:30PM - 7:15PM Debate 1: Protein Folds: Fact or Fiction?? Speaker 8 of 8 Christine A. Orengo, University College London, UK
Monday, January 11 \| 7:15PM - 8:00PM Social Hour with Lite Bites Room: Breckenridge Ballroom
Monday, January 11 \| 7:30PM - 10:00PM Large-Scale Poster Session: World-Wide Structural Genomics a nd Structural Proteomics Centers Room: Breckenridge Ballroom Structural genomic, structural proteomic and protein production centers and consortia highlight the platforms they have developed on new methods, technologies, databases, and computational tools that have spearheaded advances in protein production and structure determination for all classes of targets from bacterial to pathogens to human and on challenging macromolecules, such as membrane proteins, eukaryotic proteins and protein-protein complexes. Emphasis will be placed on what is applicable to the entire community, including single investigator laboratories to increase success and throughput in the study of biological macromolecules. An additional focus of this session will be on contributions of structural genomics to the structure and function of biological macromolecules. Megaposters are encouraged for general overviews from large and medium-sized centers. Normal sized posters are encouraged on specific aspects of structural genomics and structural proteomics, including structural and functional contributions to the study of biological macromolecules.
Tuesday, January 12 \| 7:00AM - 8:00AM Breakfast Room: Summit Gallery
Tuesday, January 12 \| 8:00AM - 11:00AM Proteomics and Protein Assemblies/Networks Room: Peak 5 Speaker 1 of 6 * Soichi Wakatsuki, Stanford University, USA
Tuesday, January 12 \| 8:00AM - 11:00AM Proteomics and Protein Assemblies/Networks Room: Peak 5 Speaker 2 of 6 Christine A. Orengo, University College London, UK Identifying Novel Genes Implicated in Function Networks of Biological and Medical Significance
Tuesday, January 12 \| 8:00AM - 11:00AM Proteomics and Protein Assemblies/Networks Room: Peak 5 Speaker 3 of 6 Adam Godzik, Sanford-Burnham Medical Research Institute, USA Structural View of the Gut Microbial Surface Proteome: Implications for Host Immunity and Health
Tuesday, January 12 \| 8:00AM - 11:00AM Proteomics and Protein Assemblies/Networks Room: Peak 5 Speaker 4 of 6 Michael Washburn, Stowers Institute for Medical Research, USA Quantitative and Probabilistic Assembly of Human Protein Interaction Networks
Tuesday, January 12 \| 8:00AM - 11:00AM Proteomics and Protein Assemblies/Networks Room: Peak 5 Speaker 5 of 6 Janet Y. Huang, Rutgers University and Northeast Structural Genomics Consortium, USA Short Talk: Human Cancer Protein Interaction Network
Tuesday, January 12 \| 8:00AM - 11:00AM Proteomics and Protein Assemblies/Networks Room: Peak 5 Speaker 6 of 6 Hannes Braberg, University of California, San Francisco, USA Functional Insights from Protein-Protein and Genetic Interaction Maps
Tuesday, January 12 \| 8:00AM - 11:15AM Macromolecular Interactions This session is from Structural Biology Room: Peaks 1-4 Speaker 1 of 7 * Andrej Sali, University of California, San Francisco, USA
Tuesday, January 12 \| 8:00AM - 11:15AM Macromolecular Interactions This session is from Structural Biology Room: Peaks 1-4 Speaker 2 of 7 James A. Wells, University of California, San Francisco, USA Trapping Allosteric Transitions in Enzymes
Tuesday, January 12 \| 8:00AM - 11:15AM Macromolecular Interactions This session is from Structural Biology Room: Peaks 1-4 Speaker 3 of 7 Pamela J. Bjorkman, California Institute of Technology, USA Fc Receptors: From Molecules to Cells
Tuesday, January 12 \| 8:00AM - 11:15AM Macromolecular Interactions This session is from Structural Biology Room: Peaks 1-4 Speaker 4 of 7 Tanja Kortemme, University of California, San Francisco, USA Prediction, Design and Engineering of Protein Interactions and Networks
Tuesday, January 12 \| 8:00AM - 11:15AM Macromolecular Interactions This session is from Structural Biology Room: Peaks 1-4 Speaker 5 of 7 Peter K. Kasson, University of Virginia, USA Short Talk: Simulations Yield New Insight into the Mechanism of Viral Membrane Fusion
Tuesday, January 12 \| 8:00AM - 11:15AM Macromolecular Interactions This session is from Structural Biology Room: Peaks 1-4 Speaker 6 of 7 Gideon Schreiber, Weizmann Institute, Israel Building a Forcefield for Protein Interface Design
Tuesday, January 12 \| 8:00AM - 11:15AM Macromolecular Interactions This session is from Structural Biology Room: Peaks 1-4 Speaker 7 of 7 Steffen Lindert, University of California, San Diego, USA Short Talk: BCL::EM-Fold: Protein Folding Tool for Medium Resolution Density Maps
Tuesday, January 12 \| 9:20AM - 9:40AM Coffee Break Room: Foyer
Tuesday, January 12 \| 11:00AM - 11:00AM On Own for Lunch and Recreation
Tuesday, January 12 \| 4:30PM - 5:00PM Coffee Available Room: Foyer
Tuesday, January 12 \| 5:00PM - 6:30PM Exploiting Structure for Function Room: Peak 5 Speaker 1 of 4 * Wayne A. Hendrickson, Columbia University, USA
Tuesday, January 12 \| 5:00PM - 6:30PM Exploiting Structure for Function Room: Peak 5 Speaker 2 of 4 Nobutaka Hirokawa, University of Tokyo, Japan Kinesin Superfamily Molecular Motors, KIFs and Intracellular Transport: Mechanism of Motility
Tuesday, January 12 \| 5:00PM - 6:30PM Exploiting Structure for Function Room: Peak 5 Speaker 3 of 4 Susan S. Taylor, University of California, San Diego, USA Conserved Architecture and Assembly of an Active Protein Kinase
Tuesday, January 12 \| 5:00PM - 6:30PM Exploiting Structure for Function Room: Peak 5 Speaker 4 of 4 Peter J. Myler, Seattle Biomedical Research Institute, USA Structural Genomics of Infectious Disease
Tuesday, January 12 \| 5:00PM - 7:00PM Macromolecular Complexes II This session is from Structural Biology Room: Peaks 1-4 Speaker 1 of 5 * R. Andrew Byrd, NCI, National Institutes of Health, USA
Tuesday, January 12 \| 5:00PM - 7:00PM Macromolecular Complexes II This session is from Structural Biology Room: Peaks 1-4 Speaker 2 of 5 Albert J.R. Heck, Utrecht University, Netherlands Native Mass Spectrometry Applied to Virus Structure and Assembly
Tuesday, January 12 \| 5:00PM - 7:00PM Macromolecular Complexes II This session is from Structural Biology Room: Peaks 1-4 Speaker 3 of 5 John (Jack) E. Johnson, The Scripps Research Institute, USA Biophysical Studies of Virus Particles and their Maturation: Insights into Elegantly Programmed Nano-Machines
Tuesday, January 12 \| 5:00PM - 7:00PM Macromolecular Complexes II This session is from Structural Biology Room: Peaks 1-4 Speaker 4 of 5 G. Marius Clore, NIDDK, National Institutes of Health, USA Short Talk: Detecting and Visualizing Sparsely Populated Protein States
Tuesday, January 12 \| 5:00PM - 7:00PM Macromolecular Complexes II This session is from Structural Biology Room: Peaks 1-4 Speaker 5 of 5 Richard W. Kriwacki, St. Jude Children's Research Hospital, USA Short Talk: PUMA-Induced Dimerization of BCL-xL Releases Cytoplasmic p53 and Promotes p53-Dependent Apoptosis
Tuesday, January 12 \| 6:30PM - 7:15PM Debate 2: Can We Really Determine Function from Structure? Speaker 1 of 8 * Ian A. Wilson, The Scripps Research Institute, USA
Tuesday, January 12 \| 6:30PM - 7:15PM Debate 2: Can We Really Determine Function from Structure? Speaker 2 of 8 Steven C. Almo, Albert Einstein College of Medicine, USA
Tuesday, January 12 \| 6:30PM - 7:15PM Debate 2: Can We Really Determine Function from Structure? Speaker 3 of 8 * Stephen K. Burley, Rutgers University, USA
Tuesday, January 12 \| 6:30PM - 7:15PM Debate 2: Can We Really Determine Function from Structure? Speaker 4 of 8 Aled M. Edwards, University of Toronto, Canada
Tuesday, January 12 \| 6:30PM - 7:15PM Debate 2: Can We Really Determine Function from Structure? Speaker 5 of 8 Andrzej Joachimiak, Argonne National Laboratory, USA
Tuesday, January 12 \| 6:30PM - 7:15PM Debate 2: Can We Really Determine Function from Structure? Speaker 6 of 8 Christine A. Orengo, University College London, UK
Tuesday, January 12 \| 6:30PM - 7:15PM Debate 2: Can We Really Determine Function from Structure? Speaker 7 of 8 Gaetano Thomas Montelione, Rutgers University, USA
Tuesday, January 12 \| 6:30PM - 7:15PM Debate 2: Can We Really Determine Function from Structure? Speaker 8 of 8 Susan S. Taylor, University of California, San Diego, USA
Tuesday, January 12 \| 7:15PM - 8:00PM Social Hour with Lite Bites Room: Breckenridge Ballroom
Tuesday, January 12 \| 8:00PM - 11:00PM Entertainment Room: Breckenridge Ballroom
Tuesday, January 12 \| 8:00PM - 11:00PM Cash Bar Room: Breckenridge Ballroom
Wednesday, January 13 \| 10:22AM - 10:22AM Departure *Session Chair †Invited, not yet responded.