Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Inflammation-Driven Cancer: Mechanisms to Therapy (2017J7)
Cell Plasticity within the Tumor Microenvironment (2017A1)
Inflammation, Infection and Cancer (2014X1)
The Role of Inflammation during Carcinogenesis (2012E2)

Web Desc
Role of Inflammation in Oncogenesis joint with Molecular and Cellular Biology of Immune Escape in Cancer Organizer(s): Nina Bhardwaj and Giorgio Trinchieri Date: February 07 - 12, 2010 Location: Keystone Resort, Keystone, CO, USA Sponsored by Celgene Corporation, Hoffmann-La Roche, Inc. and Pfizer Global Research & Development For important information on the coronavirus, please click here Summary of Meeting: Cancer is characterized by accelerated and uncontrolled growth, dysregulation of apoptosis, invasion and metastasis. While genetic and epigenetic mechanisms may underlie transformation, the tumor microenvironment promotes the neoplastic process. Chronic inflammation and infection, in particular, are linked to the development of cancer. Examples include the association between inflammatory bowel disease and colon cancer, Helicobacter pylori infection with gastric cancer and HPV with cervical cancer. Recent studies have linked the innate immune system, through production of inflammatory cytokines, with cancer progression. Factors such as TNF alpha, IL-6, and TGF beta, produced by macrophages and dendritic cells amongst other cells, enhance tumor growth, invasion, metastasis, and angiogenesis, while simultaneously impairing anti-tumor immune mechanisms. There have been several advances in our understanding of the influences of inflammation on tumorigenesis. However, critical elements of the involved inflammatory pathways that modulate tumor progression still remain to be identified. The complex interrelationship between inflammatory vs. immune suppressive cytokines and their effects on the neoplastic process remain to be defined. The association between DNA damage and inflammation and the link between pathogen associated molecular patterns (PAMPs) and novel pattern recognition molecules (TLRs and NOD like receptors) in driving tumor development require further characterization. How cancer associated inflammation might actively dysregulate the innate immune system, in particular of dendritic cell, NK and NKT cell anti-tumor function, is also an area of interest and intense speculation. This meeting will focus specifically on mechanisms of inflammation-induced carcinogenesis, and will bring together investigators with diverse interests and expertise - immunology, signal transduction, cancer biology and therapeutics. It is anticipated that the pairing with the concurrent Keystone Symposia meeting on Immune Escape in Cancer will attract a large body of scientists who share a common interest in cancer pathogenesis, inflammation and mechanisms underlying immune evasion. The goal of the meeting is to enhance discussion, foster collaborations, report on new paradigms, and ultimately to develop approaches that will modulate inflammation-associated tumor progression. Scholarship Deadline: October 7 2009 Discounted Abstract Deadline: October 7 2009 Abstract Deadline: November 6 2009 Discounted Registration Deadline: December 7 2009 We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Genentech, Inc. We gratefully acknowledge the generous grant for this conference provided by: National Cancer Institute (NCI) Grant No. 1R13CA144225-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Role of Inflammation in Oncogenesis

joint with Molecular and Cellular Biology of Immune Escape in Cancer

Organizer(s): Nina Bhardwaj and Giorgio Trinchieri

Date: February 07 - 12, 2010
Location: Keystone Resort, Keystone, CO, USA

Sponsored by Celgene Corporation, Hoffmann-La Roche, Inc. and Pfizer Global Research & Development

For important information on the coronavirus, please click here

Summary of Meeting:

Cancer is characterized by accelerated and uncontrolled growth, dysregulation of apoptosis, invasion and metastasis. While genetic and epigenetic mechanisms may underlie transformation, the tumor microenvironment promotes the neoplastic process. Chronic inflammation and infection, in particular, are linked to the development of cancer. Examples include the association between inflammatory bowel disease and colon cancer, Helicobacter pylori infection with gastric cancer and HPV with cervical cancer. Recent studies have linked the innate immune system, through production of inflammatory cytokines, with cancer progression. Factors such as TNF alpha, IL-6, and TGF beta, produced by macrophages and dendritic cells amongst other cells, enhance tumor growth, invasion, metastasis, and angiogenesis, while simultaneously impairing anti-tumor immune mechanisms. There have been several advances in our understanding of the influences of inflammation on tumorigenesis. However, critical elements of the involved inflammatory pathways that modulate tumor progression still remain to be identified. The complex interrelationship between inflammatory vs. immune suppressive cytokines and their effects on the neoplastic process remain to be defined. The association between DNA damage and inflammation and the link between pathogen associated molecular patterns (PAMPs) and novel pattern recognition molecules (TLRs and NOD like receptors) in driving tumor development require further characterization. How cancer associated inflammation might actively dysregulate the innate immune system, in particular of dendritic cell, NK and NKT cell anti-tumor function, is also an area of interest and intense speculation. This meeting will focus specifically on mechanisms of inflammation-induced carcinogenesis, and will bring together investigators with diverse interests and expertise - immunology, signal transduction, cancer biology and therapeutics. It is anticipated that the pairing with the concurrent Keystone Symposia meeting on Immune Escape in Cancer will attract a large body of scientists who share a common interest in cancer pathogenesis, inflammation and mechanisms underlying immune evasion. The goal of the meeting is to enhance discussion, foster collaborations, report on new paradigms, and ultimately to develop approaches that will modulate inflammation-associated tumor progression.

Scholarship Deadline: October 7 2009

Discounted Abstract Deadline: October 7 2009

Abstract Deadline: November 6 2009

Discounted Registration Deadline: December 7 2009

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.

We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA144225-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, February 07 \| 3:00PM - 7:30PM Registration Room: Longs Peak Foyer
Sunday, February 07 \| 6:30PM - 7:30PM Refreshments Room: Longs Peak Foyer
Sunday, February 07 \| 7:30PM - 9:30PM Keynote Session (Joint) Room: Grays/Longs Peak Speaker 1 of 6 * Nina Bhardwaj, Icahn School of Medicine at Mount Sinai, USA
Sunday, February 07 \| 7:30PM - 9:30PM Keynote Session (Joint) Room: Grays/Longs Peak Speaker 2 of 6 * Dmitry I. Gabrilovich, Wistar Institute, USA
Sunday, February 07 \| 7:30PM - 9:30PM Keynote Session (Joint) Room: Grays/Longs Peak Speaker 3 of 6 * George C. Prendergast, Lankenau Institute for Medical Research, USA
Sunday, February 07 \| 7:30PM - 9:30PM Keynote Session (Joint) Room: Grays/Longs Peak Speaker 4 of 6 * Giorgio Trinchieri, NCI, National Institutes of Health, USA
Sunday, February 07 \| 7:30PM - 9:30PM Keynote Session (Joint) Room: Grays/Longs Peak Speaker 5 of 6 Robert D. Schreiber, Washington University School of Medicine, USA Co-Evolution of Immunoediting on Oncogenesis during Tumor Formation
Sunday, February 07 \| 7:30PM - 9:30PM Keynote Session (Joint) Room: Grays/Longs Peak Speaker 6 of 6 Frances R. Balkwill, Barts Cancer Institute, Queen Mary University of London, UK Inflammatory Cytokines and Autocrine Tumor-Promoting Networks
Monday, February 08 \| 7:00AM - 8:00AM Breakfast Room: Rockies Ballroom
Monday, February 08 \| 8:00AM - 11:15AM Tumor Microenvironment and Immune Escape (Joint) Room: Grays/Longs Peak Speaker 1 of 7 * Robert D. Schreiber, Washington University School of Medicine, USA
Monday, February 08 \| 8:00AM - 11:15AM Tumor Microenvironment and Immune Escape (Joint) Room: Grays/Longs Peak Speaker 2 of 7 Lisa M. Coussens, Oregon Health & Science University, USA Role of Inflammation in Tumor Progression
Monday, February 08 \| 8:00AM - 11:15AM Tumor Microenvironment and Immune Escape (Joint) Room: Grays/Longs Peak Speaker 3 of 7 Claire E. Lewis, University of Sheffield Medical School, UK Role of Macrophages in Tumor Progression and Response to Therapy
Monday, February 08 \| 8:00AM - 11:15AM Tumor Microenvironment and Immune Escape (Joint) Room: Grays/Longs Peak Speaker 4 of 7 Arya Biragyn, NIA, National Institutes of Health, USA Short Talk: Primary Breast Cancer Actively Generates Regulatory T and B Cells (Tregs and Bregs) to Facilitate Lung Metastasis
Monday, February 08 \| 8:00AM - 11:15AM Tumor Microenvironment and Immune Escape (Joint) Room: Grays/Longs Peak Speaker 5 of 7 Gerard I. Evan, University of Cambridge, UK Immune Function and Angiogenesis in Myc-Mediated Tumor Formation
Monday, February 08 \| 8:00AM - 11:15AM Tumor Microenvironment and Immune Escape (Joint) Room: Grays/Longs Peak Speaker 6 of 7 Hans Schreiber, University of Chicago, USA The Role of Tumor Stroma in Immune Escape of Cancer
Monday, February 08 \| 8:00AM - 11:15AM Tumor Microenvironment and Immune Escape (Joint) Room: Grays/Longs Peak Speaker 7 of 7 Esteban Celis, Moffitt Cancer Center, USA Short Talk: Interferon-gamma Induced T Cell Epitope Purging: Another Mode of Tumor Immune Escape?
Monday, February 08 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Monday, February 08 \| 11:15AM - 11:15AM On Own for Lunch and Recreation
Monday, February 08 \| 11:15AM - 1:00PM Poster Setup Room: Rockies Ballroom
Monday, February 08 \| 1:00PM - 10:00PM Poster Viewing Room: Rockies Ballroom
Monday, February 08 \| 2:30PM - 4:30PM Workshop 1: Regulation of Immune Escape by Microenvironment This session is from Immune Escape in Cancer Room: Longs Peak This session will deepen understanding of the critical role of the tumor microenvironment in driving malignant progression. Speaker 1 of 7 * Dmitry I. Gabrilovich, Wistar Institute, USA
Monday, February 08 \| 2:30PM - 4:30PM Workshop 1: Regulation of Immune Escape by Microenvironment This session is from Immune Escape in Cancer Room: Longs Peak This session will deepen understanding of the critical role of the tumor microenvironment in driving malignant progression. Speaker 2 of 7 Srinivas Nagaraj, University of South Florida, College of Medicine, USA Regulation of Myeloid-Derived Suppressor Cell Activity in Cancer by CD4+ T Cells
Monday, February 08 \| 2:30PM - 4:30PM Workshop 1: Regulation of Immune Escape by Microenvironment This session is from Immune Escape in Cancer Room: Longs Peak This session will deepen understanding of the critical role of the tumor microenvironment in driving malignant progression. Speaker 3 of 7 Cassie K. Chou, University of Washington, USA Abrogation of TGFbeta Signaling Leads to Increased Persistence of Prostate Self/Tumor Antigen Specific CD8 T Cells but does not Completely Prevent Tolerization
Monday, February 08 \| 2:30PM - 4:30PM Workshop 1: Regulation of Immune Escape by Microenvironment This session is from Immune Escape in Cancer Room: Longs Peak This session will deepen understanding of the critical role of the tumor microenvironment in driving malignant progression. Speaker 4 of 7 Luca Vago, IRCCS H San Raffaele, Italy Loss of Mismatched HLA as a Mechanism of Leukemia Immune Escape in Family Haploidentical and Unrelated HSCT
Monday, February 08 \| 2:30PM - 4:30PM Workshop 1: Regulation of Immune Escape by Microenvironment This session is from Immune Escape in Cancer Room: Longs Peak This session will deepen understanding of the critical role of the tumor microenvironment in driving malignant progression. Speaker 5 of 7 Philippe Foubert, Genomics Institute of the Novartis Research Foundation, USA Blockade of Myeloid Cell Trafficking by Inhibiting a PI3-Kinase gamma-alpha4 Integrin Activation Pathway Stimulates Anti-Tumor Immunity
Monday, February 08 \| 2:30PM - 4:30PM Workshop 1: Regulation of Immune Escape by Microenvironment This session is from Immune Escape in Cancer Room: Longs Peak This session will deepen understanding of the critical role of the tumor microenvironment in driving malignant progression. Speaker 6 of 7 Sheng Wei, Moffitt Cancer Center, USA Myeloid-Derived Suppressor Cells (MDSC) are Effectors of Bone Marrow Suppression in Lower Risk Myelodysplastic Syndromes (MDS)
Monday, February 08 \| 2:30PM - 4:30PM Workshop 1: Regulation of Immune Escape by Microenvironment This session is from Immune Escape in Cancer Room: Longs Peak This session will deepen understanding of the critical role of the tumor microenvironment in driving malignant progression. Speaker 7 of 7 Michael S. Leibowitz, University of Pittsburgh, USA TAP1/2 Downregulation and CTL Evasion is Independent of STAT3 Activation in Head and Neck Cancer Cells
Monday, February 08 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Monday, February 08 \| 5:00PM - 7:00PM Inflammation in the Tumor Microenvironment Room: Grays Peak Speaker 1 of 4 * Frances R. Balkwill, Barts Cancer Institute, Queen Mary University of London, UK
Monday, February 08 \| 5:00PM - 7:00PM Inflammation in the Tumor Microenvironment Room: Grays Peak Speaker 2 of 4 Alberto Mantovani, Humanitas University, Italy Tumor Microenvironment: Sculpting the Inflammatory Response during Tumor Formation
Monday, February 08 \| 5:00PM - 7:00PM Inflammation in the Tumor Microenvironment Room: Grays Peak Speaker 3 of 4 Susan E. Erdman, Massachusetts Institute of Technology, USA Unifying Roles for Regulatory T Cells and Inflammation in Cancer
Monday, February 08 \| 5:00PM - 7:00PM Inflammation in the Tumor Microenvironment Room: Grays Peak Speaker 4 of 4 Michele W. Teng, QIMR Berghofer Medical Research Institute, Australia IL-23 Suppresses Innate Immune Response during Carcinogenesis and Metastasis
Monday, February 08 \| 5:00PM - 7:00PM Antigen-Specific Mechanisms of Tumor Escape This session is from Immune Escape in Cancer Room: Longs Peak This session will be focused on molecular and cellular mechanisms associated with role of antigens in tumor escape. Topics include tumor antigen diversity, molecular mechanisms of defective antigen presentation by tumor cells, dendritic cells and T cell tolerance. Speaker 1 of 5 * Hans Schreiber, University of Chicago, USA
Monday, February 08 \| 5:00PM - 7:00PM Antigen-Specific Mechanisms of Tumor Escape This session is from Immune Escape in Cancer Room: Longs Peak This session will be focused on molecular and cellular mechanisms associated with role of antigens in tumor escape. Topics include tumor antigen diversity, molecular mechanisms of defective antigen presentation by tumor cells, dendritic cells and T cell tolerance. Speaker 2 of 5 Thomas Blankenstein, Max Delbruck Center for Molecular Medicine, Germany No Escape
Monday, February 08 \| 5:00PM - 7:00PM Antigen-Specific Mechanisms of Tumor Escape This session is from Immune Escape in Cancer Room: Longs Peak This session will be focused on molecular and cellular mechanisms associated with role of antigens in tumor escape. Topics include tumor antigen diversity, molecular mechanisms of defective antigen presentation by tumor cells, dendritic cells and T cell tolerance. Speaker 3 of 5 Michael R. Shurin, University of Pittsburgh, USA Dendritic Cells in Immune Escape in Cancer
Monday, February 08 \| 5:00PM - 7:00PM Antigen-Specific Mechanisms of Tumor Escape This session is from Immune Escape in Cancer Room: Longs Peak This session will be focused on molecular and cellular mechanisms associated with role of antigens in tumor escape. Topics include tumor antigen diversity, molecular mechanisms of defective antigen presentation by tumor cells, dendritic cells and T cell tolerance. Speaker 4 of 5 Richard A. Flavell, HHMI/Yale University School of Medicine, USA TGF-beta Signaling in Tumoral Immune Suppression
Monday, February 08 \| 5:00PM - 7:00PM Antigen-Specific Mechanisms of Tumor Escape This session is from Immune Escape in Cancer Room: Longs Peak This session will be focused on molecular and cellular mechanisms associated with role of antigens in tumor escape. Topics include tumor antigen diversity, molecular mechanisms of defective antigen presentation by tumor cells, dendritic cells and T cell tolerance. Speaker 5 of 5 Andrew D.M. Kaiser, Netherlands Cancer Institute, Netherlands Short Talk: Low Tumor-Antigen Density Leads to PD-L1/PD-1 Mediated Suppression of Partially Exhausted CD8+ T Cells
Monday, February 08 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Rockies Ballroom
Monday, February 08 \| 7:30PM - 10:00PM Poster Session 1 Room: Rockies Ballroom
Tuesday, February 09 \| 7:00AM - 8:00AM Breakfast Room: Rockies Ballroom
Tuesday, February 09 \| 8:00AM - 11:15AM Inflammation and Carcinogenesis Room: Grays Peak Speaker 1 of 7 * Alberto Mantovani, Humanitas University, Italy
Tuesday, February 09 \| 8:00AM - 11:15AM Inflammation and Carcinogenesis Room: Grays Peak Speaker 2 of 7 Eva M. Hernando, New York University Cancer Center, USA miRNAs that Contribute to Melanoma Metastasis by Modulating Immune Evasion
Tuesday, February 09 \| 8:00AM - 11:15AM Inflammation and Carcinogenesis Room: Grays Peak Speaker 3 of 7 Yinling Hu, NCI, National Institutes of Health, USA Role of IKKalpha in Skin Cancer
Tuesday, February 09 \| 8:00AM - 11:15AM Inflammation and Carcinogenesis Room: Grays Peak Speaker 4 of 7 Pauline M. Andreu, University of California San Francisco, USA Short Talk: FcRgamma Activation Regulates Inflammation-Associated Squamous Carcinogenesis
Tuesday, February 09 \| 8:00AM - 11:15AM Inflammation and Carcinogenesis Room: Grays Peak Speaker 5 of 7 Giorgio Trinchieri, NCI, National Institutes of Health, USA Innate Resistance and Cancerogenesis
Tuesday, February 09 \| 8:00AM - 11:15AM Inflammation and Carcinogenesis Room: Grays Peak Speaker 6 of 7 Carlos Bais, Genentech, Inc., USA Stromal Cells and VEGF-Independent Angiogenesis
Tuesday, February 09 \| 8:00AM - 11:15AM Inflammation and Carcinogenesis Room: Grays Peak Speaker 7 of 7 Brendan J. Jenkins, Hudson Institute of Medical Research, Australia Short Talk: Deregulated Cytokine Signaling as a Crucial Bridge Linking Pathogen-Driven Gastric Inflammation and Tumorigenesis
Tuesday, February 09 \| 8:00AM - 11:15AM Myeloid Cells in Immune Suppression and Tumor Progression This session is from Immune Escape in Cancer Room: Longs Peak This session will focus on the molecular and cellular mechanisms of immunosuppression by different types of myeloid cells. Speaker 1 of 9 * Mario P. Colombo, Fondazione IRCCS Istituto Nazionale Tumori, Italy
Tuesday, February 09 \| 8:00AM - 11:15AM Myeloid Cells in Immune Suppression and Tumor Progression This session is from Immune Escape in Cancer Room: Longs Peak This session will focus on the molecular and cellular mechanisms of immunosuppression by different types of myeloid cells. Speaker 2 of 9 Dmitry I. Gabrilovich, Wistar Institute, USA Regulation of Myeloid-Derived Suppressor Cells in Cancer
Tuesday, February 09 \| 8:00AM - 11:15AM Myeloid Cells in Immune Suppression and Tumor Progression This session is from Immune Escape in Cancer Room: Longs Peak This session will focus on the molecular and cellular mechanisms of immunosuppression by different types of myeloid cells. Speaker 3 of 9 David H. Munn, Georgia Regents University, USA Indoleamine 2,3-Dioxygenase in Tumor Immune Escape
Tuesday, February 09 \| 8:00AM - 11:15AM Myeloid Cells in Immune Suppression and Tumor Progression This session is from Immune Escape in Cancer Room: Longs Peak This session will focus on the molecular and cellular mechanisms of immunosuppression by different types of myeloid cells. Speaker 4 of 9 David R. Gibb, Virginia Commonwealth University, USA and
Tuesday, February 09 \| 8:00AM - 11:15AM Myeloid Cells in Immune Suppression and Tumor Progression This session is from Immune Escape in Cancer Room: Longs Peak This session will focus on the molecular and cellular mechanisms of immunosuppression by different types of myeloid cells. Speaker 5 of 9 Sheinei Jamal Saleem, Virginia Commonwealth University, USA Short Talk: A Novel Model of Myeloid-Derived Suppression of the Anti-Tumor Response: Overexpression of ADAM10 Promotes Myeloid-Derived Suppressor Cell Expansion in a Tumor-Free Environment
Tuesday, February 09 \| 8:00AM - 11:15AM Myeloid Cells in Immune Suppression and Tumor Progression This session is from Immune Escape in Cancer Room: Longs Peak This session will focus on the molecular and cellular mechanisms of immunosuppression by different types of myeloid cells. Speaker 6 of 9 Vincenzo Bronte, University of Verona, Italy Forced Myelopoiesis and Immune Deviation in Cancer
Tuesday, February 09 \| 8:00AM - 11:15AM Myeloid Cells in Immune Suppression and Tumor Progression This session is from Immune Escape in Cancer Room: Longs Peak This session will focus on the molecular and cellular mechanisms of immunosuppression by different types of myeloid cells. Speaker 7 of 9 Ling Qi, Cornell University, USA Short Talk: The Metabolic Function of Myeloid-Derived Suppressor Cells in Obesity
Tuesday, February 09 \| 8:00AM - 11:15AM Myeloid Cells in Immune Suppression and Tumor Progression This session is from Immune Escape in Cancer Room: Longs Peak This session will focus on the molecular and cellular mechanisms of immunosuppression by different types of myeloid cells. Speaker 8 of 9 Cong Yan, Indiana University School of Medicine, USA Short Talk: Apoptotic Inhibition of Myeloid Cells Causes MDSC Expansion and Lung Tumorigenesis
Tuesday, February 09 \| 8:00AM - 11:15AM Myeloid Cells in Immune Suppression and Tumor Progression This session is from Immune Escape in Cancer Room: Longs Peak This session will focus on the molecular and cellular mechanisms of immunosuppression by different types of myeloid cells. Speaker 9 of 9 Anna Wasiuk, Oregon Health & Science University, USA Short Talk: Mast Cells as Regulators of Adaptive Immunity to Tumors
Tuesday, February 09 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Tuesday, February 09 \| 11:15AM - 11:15AM On Own for Lunch and Recreation
Tuesday, February 09 \| 11:15AM - 1:00PM Poster Setup Room: Rockies Ballroom
Tuesday, February 09 \| 1:00PM - 10:00PM Poster Viewing Room: Rockies Ballroom
Tuesday, February 09 \| 2:30PM - 4:30PM Workshop: Inflammation and Carcinogenesis Room: Grays Peak This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment. Speaker 1 of 10 * Jacqueline F. Bromberg, Memorial Sloan Kettering Cancer Center, USA
Tuesday, February 09 \| 2:30PM - 4:30PM Workshop: Inflammation and Carcinogenesis Room: Grays Peak This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment. Speaker 2 of 10 * Carlos Bais, Genentech, Inc., USA
Tuesday, February 09 \| 2:30PM - 4:30PM Workshop: Inflammation and Carcinogenesis Room: Grays Peak This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment. Speaker 3 of 10 David G. DeNardo, Washington University Medical School, USA CD4+ T Lymphocytes Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing the Pro-Tumor Properties of Macrophages
Tuesday, February 09 \| 2:30PM - 4:30PM Workshop: Inflammation and Carcinogenesis Room: Grays Peak This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment. Speaker 4 of 10 Mercedes B. Fuertes, University of Chicago, USA Host Type I IFN Signals Mediate Awareness of Tumor and Promote Spontaneous Adaptive Immune Responses Against Tumor-Associated Antigens
Tuesday, February 09 \| 2:30PM - 4:30PM Workshop: Inflammation and Carcinogenesis Room: Grays Peak This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment. Speaker 5 of 10 Esther N. Arwert, Francis Crick Institute, UK Tumor Formation Initiated by Nondividing Epidermal Cells via an Inflammatory Infiltrate
Tuesday, February 09 \| 2:30PM - 4:30PM Workshop: Inflammation and Carcinogenesis Room: Grays Peak This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment. Speaker 6 of 10 Jack D. Bui, University of California, San Diego, USA Evidence for Macrophage-Mediated Cancer Immunoediting
Tuesday, February 09 \| 2:30PM - 4:30PM Workshop: Inflammation and Carcinogenesis Room: Grays Peak This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment. Speaker 7 of 10 Sharon A. Glynn, National University of Ireland Galway, Ireland Joint Expression of NOS2 and COX2 in ER-Negative Breast Cancer – Acquisition of a Poor Prognosis Phenotype
Tuesday, February 09 \| 2:30PM - 4:30PM Workshop: Inflammation and Carcinogenesis Room: Grays Peak This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment. Speaker 8 of 10 Abby L. Geis, Arkansas College of Osteopathic Medicine, USA A Human Commensal Promotes Colorectal Cancer in Min Mice: Role of the Treg / Th17 Balance in the colitis-Induced Carcinogenesis
Tuesday, February 09 \| 2:30PM - 4:30PM Workshop: Inflammation and Carcinogenesis Room: Grays Peak This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment. Speaker 9 of 10 Maria Grazia Ruocco, Skirball, New York University School of Medicine, USA Stress-Induced Signals Facilitate T Cell Arrest and Lead to Tumor Eradication
Tuesday, February 09 \| 2:30PM - 4:30PM Workshop: Inflammation and Carcinogenesis Room: Grays Peak This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment. Speaker 10 of 10 Li Yang, NCI, National Institutes of Health, USA Short Talk: TGFbeta, an Inflammation and Immune Suppressor in Tumor Progression
Tuesday, February 09 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Tuesday, February 09 \| 5:00PM - 7:00PM Innate Resistance and Tumor Escape Room: Grays Peak Speaker 1 of 4 * Nina Bhardwaj, Icahn School of Medicine at Mount Sinai, USA
Tuesday, February 09 \| 5:00PM - 7:00PM Innate Resistance and Tumor Escape Room: Grays Peak Speaker 2 of 4 David H. Raulet, University of California, Berkeley, USA NKG2D, NKG2D Ligands and Spontaneous Malignancy
Tuesday, February 09 \| 5:00PM - 7:00PM Innate Resistance and Tumor Escape Room: Grays Peak Speaker 3 of 4 Laurence Zitvogel, Institut Gustave Roussy, France NKp30/NCR3 Isoforms and Prognosis of Human Malignancies: Revisiting the DC/NK Cross Talk
Tuesday, February 09 \| 5:00PM - 7:00PM Innate Resistance and Tumor Escape Room: Grays Peak Speaker 4 of 4 Mark J. Smyth, QIMR Berghofer Medical Research Institute, Australia Suppression and Innate Immune Surveillance
Tuesday, February 09 \| 5:00PM - 7:00PM Regulatory T and NKT Cells in Immune Escape This session is from Immune Escape in Cancer Room: Longs Peak This session is focused on molecular and cellular mechanisms of regulatory T cell function in cancers. Specific topics can include novel findings on the role of classical Treg in cancer, different types of Tregs, and role of NKT. Speaker 1 of 5 * Vincenzo Bronte, University of Verona, Italy
Tuesday, February 09 \| 5:00PM - 7:00PM Regulatory T and NKT Cells in Immune Escape This session is from Immune Escape in Cancer Room: Longs Peak This session is focused on molecular and cellular mechanisms of regulatory T cell function in cancers. Specific topics can include novel findings on the role of classical Treg in cancer, different types of Tregs, and role of NKT. Speaker 2 of 5 Harald von Boehmer, Harvard Medical School, USA In vivo Induction of Antigen-Specific Regulatory T Cells to Prevent Unwanted Immunity
Tuesday, February 09 \| 5:00PM - 7:00PM Regulatory T and NKT Cells in Immune Escape This session is from Immune Escape in Cancer Room: Longs Peak This session is focused on molecular and cellular mechanisms of regulatory T cell function in cancers. Specific topics can include novel findings on the role of classical Treg in cancer, different types of Tregs, and role of NKT. Speaker 3 of 5 Rong-Fu Wang, Baylor College of Medicine, USA Immunosuppressive gammadelta Treg and other Immune Cells and their Functional Regulation through Innate Immune Signaling
Tuesday, February 09 \| 5:00PM - 7:00PM Regulatory T and NKT Cells in Immune Escape This session is from Immune Escape in Cancer Room: Longs Peak This session is focused on molecular and cellular mechanisms of regulatory T cell function in cancers. Specific topics can include novel findings on the role of classical Treg in cancer, different types of Tregs, and role of NKT. Speaker 4 of 5 Mario P. Colombo, Fondazione IRCCS Istituto Nazionale Tumori, Italy OX40 Costimulation in Treg Functions
Tuesday, February 09 \| 5:00PM - 7:00PM Regulatory T and NKT Cells in Immune Escape This session is from Immune Escape in Cancer Room: Longs Peak This session is focused on molecular and cellular mechanisms of regulatory T cell function in cancers. Specific topics can include novel findings on the role of classical Treg in cancer, different types of Tregs, and role of NKT. Speaker 5 of 5 Jay A. Berzofsky, NCI, National Institutes of Health, USA Short Talk: Tipping the Balance in the NKT Cell Regulation of Tumor Immunity
Tuesday, February 09 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Rockies Ballroom
Tuesday, February 09 \| 7:30PM - 10:00PM Poster Session 2 Room: Rockies Ballroom
Wednesday, February 10 \| 7:00AM - 8:00AM Breakfast Room: Rockies Ballroom
Wednesday, February 10 \| 8:00AM - 11:15AM Transcriptional Regulation of Immune Escape (Joint) Room: Grays/Longs Peak Speaker 1 of 7 * George C. Prendergast, Lankenau Institute for Medical Research, USA
Wednesday, February 10 \| 8:00AM - 11:15AM Transcriptional Regulation of Immune Escape (Joint) Room: Grays/Longs Peak Speaker 2 of 7 Hua E. Yu, Beckman Research Institute, City of Hope, USA STAT3 in Cancer Inflammation and Immune Escape
Wednesday, February 10 \| 8:00AM - 11:15AM Transcriptional Regulation of Immune Escape (Joint) Room: Grays/Longs Peak Speaker 3 of 7 Erwin F. Wagner, Spanish National Cancer Research Centre, Spain Stress-responsive and context dependent transcription factor complex
Wednesday, February 10 \| 8:00AM - 11:15AM Transcriptional Regulation of Immune Escape (Joint) Room: Grays/Longs Peak Speaker 4 of 7 Mitsugu Fujita, University of Pittsburgh Cancer Institute, USA A Pivotal Role of Type-1 Interferons in Anti-glioma Immunosurveillance
Wednesday, February 10 \| 8:00AM - 11:15AM Transcriptional Regulation of Immune Escape (Joint) Room: Grays/Longs Peak Speaker 5 of 7 Thomas Gajewski, University of Chicago, USA Transcriptional regulation of T cell anergy: Implications for cancer immunotherapy
Wednesday, February 10 \| 8:00AM - 11:15AM Transcriptional Regulation of Immune Escape (Joint) Room: Grays/Longs Peak Speaker 6 of 7 Michael Karin, University of California, San Diego, USA Tumor elicited inflammation and lymphocyte infiltrates in metastatic progression
Wednesday, February 10 \| 8:00AM - 11:15AM Transcriptional Regulation of Immune Escape (Joint) Room: Grays/Longs Peak Speaker 7 of 7 Jahan Khalili, MD Anderson Cancer Center, USA Short Talk: The Role of B-raf V600E Mutation on PD-1 Ligand Expression in Melanocytic nevi
Wednesday, February 10 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Wednesday, February 10 \| 11:15AM - 11:15AM On Own for Lunch and Recreation
Wednesday, February 10 \| 11:15AM - 1:00PM Poster Setup Room: Rockies Ballroom
Wednesday, February 10 \| 1:00PM - 10:00PM Poster Viewing Room: Rockies Ballroom
Wednesday, February 10 \| 2:30PM - 4:30PM Workshop 2: Tumor Recruitment of Immune Cells: Roles in Tumo r Progression and Immune Escape This session is from Immune Escape in Cancer Room: Longs Peak Consider roles for MDSCs, B cells, mast cells, microvesicle transfer, etc. Speaker 1 of 7 * Michael R. Shurin, University of Pittsburgh, USA
Wednesday, February 10 \| 2:30PM - 4:30PM Workshop 2: Tumor Recruitment of Immune Cells: Roles in Tumo r Progression and Immune Escape This session is from Immune Escape in Cancer Room: Longs Peak Consider roles for MDSCs, B cells, mast cells, microvesicle transfer, etc. Speaker 2 of 7 Courtney Smith, Lankenau Institute for Medical Research, USA Indoleamine 2,3-Dioxygenase (IDO) Supports Metastatic Outgrowth of the 4T1 Breast Cancer Mouse Model
Wednesday, February 10 \| 2:30PM - 4:30PM Workshop 2: Tumor Recruitment of Immune Cells: Roles in Tumo r Progression and Immune Escape This session is from Immune Escape in Cancer Room: Longs Peak Consider roles for MDSCs, B cells, mast cells, microvesicle transfer, etc. Speaker 3 of 7 Melody A. Swartz, University of Chicago, USA Lymph Node Mimicry by Tumors Promotes Immunological Tolerance
Wednesday, February 10 \| 2:30PM - 4:30PM Workshop 2: Tumor Recruitment of Immune Cells: Roles in Tumo r Progression and Immune Escape This session is from Immune Escape in Cancer Room: Longs Peak Consider roles for MDSCs, B cells, mast cells, microvesicle transfer, etc. Speaker 4 of 7 Stephanie Watkins, National Cancer Institute, National Institutes of Health, USA Prostate Tumor-Associated Dendritic Cell Induction of Tolerance and Suppressor Activity in Tumor-Infiltrating CTLs is Associated with FOXO3a Expression
Wednesday, February 10 \| 2:30PM - 4:30PM Workshop 2: Tumor Recruitment of Immune Cells: Roles in Tumo r Progression and Immune Escape This session is from Immune Escape in Cancer Room: Longs Peak Consider roles for MDSCs, B cells, mast cells, microvesicle transfer, etc. Speaker 5 of 7 Rongcun Yang, Nankai University, China Suppressor of Cytokine Signaling-3 (SOCS3) Downregulates the Ability of Pyruvate Kinase Type M2 to Cause Dendritic Cell Dysfunction
Wednesday, February 10 \| 2:30PM - 4:30PM Workshop 2: Tumor Recruitment of Immune Cells: Roles in Tumo r Progression and Immune Escape This session is from Immune Escape in Cancer Room: Longs Peak Consider roles for MDSCs, B cells, mast cells, microvesicle transfer, etc. Speaker 6 of 7 Kyle C. McKenna, University of Pittsburgh, USA Short Talk: Inhibited Function of Intratumoral F4/80+ Macrophages Contributes to the Failure of CD8+ CTL to Control Ocular Tumor Development
Wednesday, February 10 \| 2:30PM - 4:30PM Workshop 2: Tumor Recruitment of Immune Cells: Roles in Tumo r Progression and Immune Escape This session is from Immune Escape in Cancer Room: Longs Peak Consider roles for MDSCs, B cells, mast cells, microvesicle transfer, etc. Speaker 7 of 7 Andreas Herrmann, Beckman Research Institute, USA Short Talk: Stat3 is a Molecular Target for Improving Adoptive T cell Therapy
Wednesday, February 10 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Wednesday, February 10 \| 5:00PM - 7:00PM Innate Receptors, Cancer and Inflammation Room: Grays Peak Speaker 1 of 5 * Mark J. Smyth, QIMR Berghofer Medical Research Institute, Australia
Wednesday, February 10 \| 5:00PM - 7:00PM Innate Receptors, Cancer and Inflammation Room: Grays Peak Speaker 2 of 5 Xiaoxia Li, Cleveland Clinic Foundation, USA SIGIRR-Mediated Tumor Suppression
Wednesday, February 10 \| 5:00PM - 7:00PM Innate Receptors, Cancer and Inflammation Room: Grays Peak Speaker 3 of 5 Felix Yarovinsky, University of Rochester Medical Center, USA Short Talk: A Novel Transgenic Mouse Model for Chronic Inflammation: Linking Toll-like Receptor (TLR) Responses with Carcinogenesis
Wednesday, February 10 \| 5:00PM - 7:00PM Innate Receptors, Cancer and Inflammation Room: Grays Peak Speaker 4 of 5 Nina Linde, German Cancer Research Center (DKFZ), Germany Inflammation in Epithelial Skin Tumors
Wednesday, February 10 \| 5:00PM - 7:00PM Innate Receptors, Cancer and Inflammation Room: Grays Peak Speaker 5 of 5 Irving C. Allen, Virginia Tech, USA Short Talk: NLRP3 is an Essential Regulator of Interleukin-1beta and Interleukin-18 during Inflammation Driven Colon Tumorigenesis
Wednesday, February 10 \| 5:00PM - 7:00PM Immune Inhibitory Receptors in Cancer This session is from Immune Escape in Cancer Room: Longs Peak Speaker 1 of 6 * Augusto C. Ochoa, Louisiana State University Health Sciences Center, USA
Wednesday, February 10 \| 5:00PM - 7:00PM Immune Inhibitory Receptors in Cancer This session is from Immune Escape in Cancer Room: Longs Peak Speaker 2 of 6 Drew M. Pardoll, Johns Hopkins University School of Medicine, USA Mechanism of T-Cell Tolerance in Cancer Mediated by Inhibitory Receptors
Wednesday, February 10 \| 5:00PM - 7:00PM Immune Inhibitory Receptors in Cancer This session is from Immune Escape in Cancer Room: Longs Peak Speaker 3 of 6 Hyam I. Levitsky, Century Therapeutics, USA Mechanism of T-Cell Tolerance in Cancer
Wednesday, February 10 \| 5:00PM - 7:00PM Immune Inhibitory Receptors in Cancer This session is from Immune Escape in Cancer Room: Longs Peak Speaker 4 of 6 Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA Short Talk: Official title unknown. Topic was IL-35 and its role in regulation of T cell function
Wednesday, February 10 \| 5:00PM - 7:00PM Immune Inhibitory Receptors in Cancer This session is from Immune Escape in Cancer Room: Longs Peak Speaker 5 of 6 George Coukos, University Hospital of Lausanne - CHUV, Switzerland Hypoxia Recruits Regulatory T Cells via the CCL28 Chemokine to Promote Tolerance and Angiogenesis in Cancer
Wednesday, February 10 \| 5:00PM - 7:00PM Immune Inhibitory Receptors in Cancer This session is from Immune Escape in Cancer Room: Longs Peak Speaker 6 of 6 Daniel Hirschhorn-Cymerman, Memorial Sloan-Kettering Cancer Center, USA Short Talk: OX40 Engagement and Chemotherapy Combination Provides Potent Anti-Tumor Immunity with Concomitant Regulatory T Cell Apoptosis
Wednesday, February 10 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Rockies Ballroom
Wednesday, February 10 \| 7:30PM - 10:00PM Poster Session 3 Room: Rockies Ballroom
Thursday, February 11 \| 7:00AM - 8:00AM Breakfast Room: Rockies Ballroom
Thursday, February 11 \| 8:00AM - 11:00AM Dendritic Cells and Macrophages in Cancer Room: Grays Peak Speaker 1 of 6 * Laurence Zitvogel, Institut Gustave Roussy, France
Thursday, February 11 \| 8:00AM - 11:00AM Dendritic Cells and Macrophages in Cancer Room: Grays Peak Speaker 2 of 6 Nina Bhardwaj, Icahn School of Medicine at Mount Sinai, USA Modulating Inflammatory Dendritic Cell Responses against Cancer
Thursday, February 11 \| 8:00AM - 11:00AM Dendritic Cells and Macrophages in Cancer Room: Grays Peak Speaker 3 of 6 Shannon J. Turley, Genentech, Inc., USA Novel Aspects of Tolerance in the Tumor Microenvironment
Thursday, February 11 \| 8:00AM - 11:00AM Dendritic Cells and Macrophages in Cancer Room: Grays Peak Speaker 4 of 6 Miriam Merad, Mount Sinai School of Medicine, USA Identification of a DC lineage with unique functions in tissues immunity
Thursday, February 11 \| 8:00AM - 11:00AM Dendritic Cells and Macrophages in Cancer Room: Grays Peak Speaker 5 of 6 Ana Carrizosa Anderson, Harvard Medical School, USA New Roles for TIM Family Members in Immune Regulation
Thursday, February 11 \| 8:00AM - 11:00AM Dendritic Cells and Macrophages in Cancer Room: Grays Peak Speaker 6 of 6 Emmanuelle Godefroy, New York University, School of Medicine, USA Short Talk: MMP-2 Conditions Dendritic Cells to Prime Inflammatory TH2 Cells via an IL-12 and OX40L-Dependent Pathway
Thursday, February 11 \| 8:00AM - 11:15AM Metabolic Pathways Involved in Immune Escape This session is from Immune Escape in Cancer Room: Longs Peak This session will be focused on the role of metabolism of carbohydrates, lipids, arginine, tryptophan, and exosomes in tumor escape. Speaker 1 of 7 * Drew M. Pardoll, Johns Hopkins University School of Medicine, USA
Thursday, February 11 \| 8:00AM - 11:15AM Metabolic Pathways Involved in Immune Escape This session is from Immune Escape in Cancer Room: Longs Peak This session will be focused on the role of metabolism of carbohydrates, lipids, arginine, tryptophan, and exosomes in tumor escape. Speaker 2 of 7 Gabriel A. Rabinovich, Instituto de Biologia y Medicina Experimental, Argentina 'Turning Sweet' on Immunity: Galectin-Glycan Interactions in T-Cell and Dendritic Cell Physiology
Thursday, February 11 \| 8:00AM - 11:15AM Metabolic Pathways Involved in Immune Escape This session is from Immune Escape in Cancer Room: Longs Peak This session will be focused on the role of metabolism of carbohydrates, lipids, arginine, tryptophan, and exosomes in tumor escape. Speaker 3 of 7 Suzanne Ostrand-Rosenberg, University of Maryland, USA Myeloid Cells, Inflammation, and Anti-Tumor Immunity: Not an Auspicious Combination
Thursday, February 11 \| 8:00AM - 11:15AM Metabolic Pathways Involved in Immune Escape This session is from Immune Escape in Cancer Room: Longs Peak This session will be focused on the role of metabolism of carbohydrates, lipids, arginine, tryptophan, and exosomes in tumor escape. Speaker 4 of 7 Linglin Yang, University of Maryland, Baltimore County, USA Short Talk: Indoleamine 2,3-Dioxygenase (IDO) Contributes to Myeloid-Derived Suppressor Cell- Mediated Tumor Suppression through Interleukin-6 Signaling Pathway
Thursday, February 11 \| 8:00AM - 11:15AM Metabolic Pathways Involved in Immune Escape This session is from Immune Escape in Cancer Room: Longs Peak This session will be focused on the role of metabolism of carbohydrates, lipids, arginine, tryptophan, and exosomes in tumor escape. Speaker 5 of 7 Augusto C. Ochoa, Louisiana State University Health Sciences Center, USA Arginine Depletion by MDSC in vivo, a Mechanism of Tumor Escape
Thursday, February 11 \| 8:00AM - 11:15AM Metabolic Pathways Involved in Immune Escape This session is from Immune Escape in Cancer Room: Longs Peak This session will be focused on the role of metabolism of carbohydrates, lipids, arginine, tryptophan, and exosomes in tumor escape. Speaker 6 of 7 Licia Rivoltini, Fondazione IRCCS Istituto Nazionale Tumori, Italy Tumor-Derived Microvesicles and Immune Defects in Human Cancer
Thursday, February 11 \| 8:00AM - 11:15AM Metabolic Pathways Involved in Immune Escape This session is from Immune Escape in Cancer Room: Longs Peak This session will be focused on the role of metabolism of carbohydrates, lipids, arginine, tryptophan, and exosomes in tumor escape. Speaker 7 of 7 Jonathan D. Silk, University of Oxford, UK Short Talk: A Novel Amino Acid Transporter Induced by Expression of Indoleamine 2,3 Dioxygenase in Tumors
Thursday, February 11 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Thursday, February 11 \| 11:00AM - 11:00AM On Own for Lunch and Recreation
Thursday, February 11 \| 2:30PM - 4:30PM Workshop 3: Novel Strategies to Reverse Immune Escape in Can cer This session is from Immune Escape in Cancer Room: Longs Peak Will discuss novel approaches to reversal of immune defects in cancer. Topics may include cytokines supporting productive immune response, block of inhibitory cytokines and receptors, regulation of immune responses via toll-like receptors, etc. Speaker 1 of 6 Juan R. Cubillos-Ruiz, Weill Cornell Medical College, USA siRNA Delivery through Novel TLR5-Agonist Polyethylenimine Reprograms Tumor-Associated Regulatory Dendritic Cells to Elicit Therapeutic Immunity
Thursday, February 11 \| 2:30PM - 4:30PM Workshop 3: Novel Strategies to Reverse Immune Escape in Can cer This session is from Immune Escape in Cancer Room: Longs Peak Will discuss novel approaches to reversal of immune defects in cancer. Topics may include cytokines supporting productive immune response, block of inhibitory cytokines and receptors, regulation of immune responses via toll-like receptors, etc. Speaker 2 of 6 Viktor Umansky, German Cancer Research Center, Germany Blocking of Myeloid Derived Suppressor Cell (MDSC) Functions Results in Antitumor Effects in Ret Transgenic Mouse Melanoma Model
Thursday, February 11 \| 2:30PM - 4:30PM Workshop 3: Novel Strategies to Reverse Immune Escape in Can cer This session is from Immune Escape in Cancer Room: Longs Peak Will discuss novel approaches to reversal of immune defects in cancer. Topics may include cytokines supporting productive immune response, block of inhibitory cytokines and receptors, regulation of immune responses via toll-like receptors, etc. Speaker 3 of 6 Xiangdong Liu, Incyte Corporation, USA INCB24360, a Potent and Selective Inhibitor of Indoleamine 2,3-dioxygenase (IDO) for Cancer Immunotherapy
Thursday, February 11 \| 2:30PM - 4:30PM Workshop 3: Novel Strategies to Reverse Immune Escape in Can cer This session is from Immune Escape in Cancer Room: Longs Peak Will discuss novel approaches to reversal of immune defects in cancer. Topics may include cytokines supporting productive immune response, block of inhibitory cytokines and receptors, regulation of immune responses via toll-like receptors, etc. Speaker 4 of 6 Ge Ma, Mount Sinai School of Medicine, USA Paired Immunoglobin Like Receptor-B (PIRB) Regulates the Suppressive Function and M1 versus M2 Differentiation of MDSC
Thursday, February 11 \| 2:30PM - 4:30PM Workshop 3: Novel Strategies to Reverse Immune Escape in Can cer This session is from Immune Escape in Cancer Room: Longs Peak Will discuss novel approaches to reversal of immune defects in cancer. Topics may include cytokines supporting productive immune response, block of inhibitory cytokines and receptors, regulation of immune responses via toll-like receptors, etc. Speaker 5 of 6 Carl E. Ruby, Rush University Medical Center, USA Characterizing the Effect of Aging in Tumor-Bearing Hosts Treated with OX40 Agonists
Thursday, February 11 \| 2:30PM - 4:30PM Workshop 3: Novel Strategies to Reverse Immune Escape in Can cer This session is from Immune Escape in Cancer Room: Longs Peak Will discuss novel approaches to reversal of immune defects in cancer. Topics may include cytokines supporting productive immune response, block of inhibitory cytokines and receptors, regulation of immune responses via toll-like receptors, etc. Speaker 6 of 6 Thorbald van Hall, Leiden University Medical Center, Netherlands A Novel Category of Tumor Antigens Enable CTL Immunity to Tumor Escape Variants
Thursday, February 11 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Thursday, February 11 \| 5:00PM - 7:00PM Cytokines in the Tumor Microenvironment Room: Grays Peak Speaker 1 of 6 * Giorgio Trinchieri, NCI, National Institutes of Health, USA
Thursday, February 11 \| 5:00PM - 7:00PM Cytokines in the Tumor Microenvironment Room: Grays Peak Speaker 2 of 6 Jacqueline F. Bromberg, Memorial Sloan Kettering Cancer Center, USA The IL-6/Stat3 Signaling Pathway Promotes Mammary Tumorigenesis and Metastases
Thursday, February 11 \| 5:00PM - 7:00PM Cytokines in the Tumor Microenvironment Room: Grays Peak Speaker 3 of 6 Martin Oft, ARMO BioSciences, USA Switching Tumor Promoting Inflammation into Tumor Immune Surveillance
Thursday, February 11 \| 5:00PM - 7:00PM Cytokines in the Tumor Microenvironment Room: Grays Peak Speaker 4 of 6 Charles G. Drake, Columbia University, USA Th17 Cells in Tumors
Thursday, February 11 \| 5:00PM - 7:00PM Cytokines in the Tumor Microenvironment Room: Grays Peak Speaker 5 of 6 Jiyoung Park, Ulsan National Institute of Science and Technology, South Korea Short Talk: Peripheral Leptin Promotes Mammary Tumor Progression and Metastasis through Activation of the Jak2/STAT3 Pathway in vivo
Thursday, February 11 \| 5:00PM - 7:00PM Cytokines in the Tumor Microenvironment Room: Grays Peak Speaker 6 of 6 Alexander J. Muller, Lankenau Institute for Medical Research, USA Short Talk: IDO Contributes to Pathologies Associated with Chronic Inflammation
Thursday, February 11 \| 5:00PM - 7:15PM Therapeutic Development to Correct Immune Escape in Cancer This session is from Immune Escape in Cancer Room: Longs Peak This session will discuss preclinical and clinical development of different approaches to counter immune suppressive mechanisms in cancer. Speaker 1 of 6 * Hyam I. Levitsky, Century Therapeutics, USA
Thursday, February 11 \| 5:00PM - 7:15PM Therapeutic Development to Correct Immune Escape in Cancer This session is from Immune Escape in Cancer Room: Longs Peak This session will discuss preclinical and clinical development of different approaches to counter immune suppressive mechanisms in cancer. Speaker 2 of 6 Alexander J. Muller, Lankenau Institute for Medical Research, USA Short Talk: IDO Contributes to Pathologies Associated with Chronic Inflammation
Thursday, February 11 \| 5:00PM - 7:15PM Therapeutic Development to Correct Immune Escape in Cancer This session is from Immune Escape in Cancer Room: Longs Peak This session will discuss preclinical and clinical development of different approaches to counter immune suppressive mechanisms in cancer. Speaker 3 of 6 George C. Prendergast, Lankenau Institute for Medical Research, USA Regulation and Therapeutic Inhibition of IDO/IDO2 in Cancer
Thursday, February 11 \| 5:00PM - 7:15PM Therapeutic Development to Correct Immune Escape in Cancer This session is from Immune Escape in Cancer Room: Longs Peak This session will discuss preclinical and clinical development of different approaches to counter immune suppressive mechanisms in cancer. Speaker 4 of 6 Jedd D. Wolchok, Memorial Sloan Kettering Cancer Center, USA The Whys and Wherefores of CTLA-4 Blockade
Thursday, February 11 \| 5:00PM - 7:15PM Therapeutic Development to Correct Immune Escape in Cancer This session is from Immune Escape in Cancer Room: Longs Peak This session will discuss preclinical and clinical development of different approaches to counter immune suppressive mechanisms in cancer. Speaker 5 of 6 Suzanne L. Topalian, Johns Hopkins University School of Medicine, USA Modulating Anti-tumor Immunity through Checkpoint Blockade: B7-H1/PD-1 Interactions
Thursday, February 11 \| 5:00PM - 7:15PM Therapeutic Development to Correct Immune Escape in Cancer This session is from Immune Escape in Cancer Room: Longs Peak This session will discuss preclinical and clinical development of different approaches to counter immune suppressive mechanisms in cancer. Speaker 6 of 6 Jeffrey Weber, New York University, USA Regulation of Immune Responses in Cancer via Checkpoint Blockade of Negative Receptors in Melanoma
Thursday, February 11 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Rockies Ballroom
Thursday, February 11 \| 8:00PM - 11:00PM Entertainment Room: Rockies Ballroom
Thursday, February 11 \| 8:00PM - 11:00PM Cash Bar Room: Rockies Ballroom
Friday, February 12 \| 10:22AM - 10:22AM Departure *Session Chair †Invited, not yet responded.