Web Desc
Molecular and Cellular Biology of Immune Escape in Cancer
joint with Role of Inflammation in Oncogenesis
Organizer(s): George C. Prendergast and Dmitry I. Gabrilovich
Date: February 07 - 12, 2010
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Astellas Pharma Inc. and Genentech BioOncology
Summary of Meeting:
It is now widely recognized that the immune microenvironment of a tumor provides critical support in determining its progression versus dormancy or destruction. To gain immune benefits the tumor must evolve mechanisms of immune escape. Study of this crucial process requires cross-fertilization between molecular cell biologists and tumor immunologists who do not tend to interact. This problem is also integrated with the problem of cancer inflammation that has captured the attention of tumor biologists focused on transgenic mouse models and clinical settings. Thus, we propose a unique conference – the first of its kind – to integrate perspectives from a diverse set of researchers in cancer, immunology, and molecular therapeutics and to focus specifically on immune escape and tumor-induced immune suppression as a multidisciplinary problem. Cancer is initiated by the accumulation of genetic and epigenetic changes in a normal cell, but its progression depends on the stromal and immune microenvironment of the initiated cell. While intrinsic signals within the initiated cell drive neoplastic transformation and genomic plasticity, extrinsic signals delivered by immune cells are critical in dictating whether progression versus dormancy or destruction of an initiated lesion takes place, and also whether metastasis may occur. The high degree of genomic plasticity in cancer cells permits them to develop sophisticated ways to prevent the immune system from recognizing and eliminating tumor cells. It has become increasingly clear in recent years that abnormalities in the immune system that are induced by tumors not only hamper natural anti-tumor immune surveillance but also limit the efficacy of immunotherapy and even traditional chemotherapy and radiotherapy. Thus, tumor-induced immune abnormalities may not only impact the clinical course of disease but also the prospects for its therapeutic management. Recent results indicate that we are on the verge of a real breakthrough in our understanding of how tumors thwart the immune system and how correcting immune escape could vastly improve cancer therapy. However, at present the available mechanistic information presents a somewhat convoluted picture that includes some seemingly contradictory elements. While this situation is a natural stage of development in the field, there is nevertheless a pressing need to define key questions and organize their development in coherent ways that can speed improvements in cancer therapy.
Scholarship Deadline: October 7 2009
Discounted Abstract Deadline: October 7 2009
Abstract Deadline: November 6 2009
Discounted Registration Deadline: December 7 2009
We gratefully acknowledge additional support for this conference from:
Astellas Pharma Inc.CytoAnalyticsGenentech BioOncologyRoyal Society of Chemistry


George Prendergast
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA144231-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 07 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Sunday, February 07 | 6:30PM - 7:30PM
Refreshments
Room: Longs Peak Foyer


Sunday, February 07 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Grays/Longs Peak

Speaker 1 of 6
* Nina Bhardwaj, Icahn School of Medicine at Mount Sinai, USA

Sunday, February 07 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Grays/Longs Peak

Speaker 2 of 6
* Dmitry I. Gabrilovich, AstraZeneca, USA

Sunday, February 07 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Grays/Longs Peak

Speaker 3 of 6
* George C. Prendergast, Lankenau Institute for Medical Research, USA

Sunday, February 07 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Grays/Longs Peak

Speaker 4 of 6
* Giorgio Trinchieri, NCI, National Institutes of Health, USA

Sunday, February 07 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Grays/Longs Peak

Speaker 5 of 6
Robert D. Schreiber, Washington University School of Medicine, USA
Co-Evolution of Immunoediting on Oncogenesis during Tumor Formation

Sunday, February 07 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Grays/Longs Peak

Speaker 6 of 6
Frances R. Balkwill, Barts Cancer Institute, Queen Mary University of London, UK
Inflammatory Cytokines and Autocrine Tumor-Promoting Networks

Monday, February 08 | 7:00AM - 8:00AM
Breakfast
Room: Quandary


Monday, February 08 | 8:00AM - 11:15AM
Tumor Microenvironment and Immune Escape (Joint)
Room: Grays/Longs Peak
This session will be focused on how stromal cells, inflammation, and angiogenesis support malignant progression, highlighting crucial roles for immune cells in contributing to these processes.
Speaker 1 of 7
* Robert D. Schreiber, Washington University School of Medicine, USA

Monday, February 08 | 8:00AM - 11:15AM
Tumor Microenvironment and Immune Escape (Joint)
Room: Grays/Longs Peak
This session will be focused on how stromal cells, inflammation, and angiogenesis support malignant progression, highlighting crucial roles for immune cells in contributing to these processes.
Speaker 2 of 7
Lisa M. Coussens, Oregon Health & Science University, USA
Role of Inflammation in Tumor Progression

Monday, February 08 | 8:00AM - 11:15AM
Tumor Microenvironment and Immune Escape (Joint)
Room: Grays/Longs Peak
This session will be focused on how stromal cells, inflammation, and angiogenesis support malignant progression, highlighting crucial roles for immune cells in contributing to these processes.
Speaker 3 of 7
Claire E. Lewis, University of Sheffield Medical School, UK
Role of Macrophages in Tumor Progression and Response to Therapy

Monday, February 08 | 8:00AM - 11:15AM
Tumor Microenvironment and Immune Escape (Joint)
Room: Grays/Longs Peak
This session will be focused on how stromal cells, inflammation, and angiogenesis support malignant progression, highlighting crucial roles for immune cells in contributing to these processes.
Speaker 4 of 7
Arya Biragyn, NIA, National Institutes of Health, USA
Short Talk: Primary Breast Cancer Actively Generates Regulatory T and B Cells (Tregs and Bregs) to Facilitate Lung Metastasis

Monday, February 08 | 8:00AM - 11:15AM
Tumor Microenvironment and Immune Escape (Joint)
Room: Grays/Longs Peak
This session will be focused on how stromal cells, inflammation, and angiogenesis support malignant progression, highlighting crucial roles for immune cells in contributing to these processes.
Speaker 5 of 7
Gerard I. Evan, University of Cambridge, UK
Immune Function and Angiogenesis in Myc-mediated Tumor Formation

Monday, February 08 | 8:00AM - 11:15AM
Tumor Microenvironment and Immune Escape (Joint)
Room: Grays/Longs Peak
This session will be focused on how stromal cells, inflammation, and angiogenesis support malignant progression, highlighting crucial roles for immune cells in contributing to these processes.
Speaker 6 of 7
Hans Schreiber, University of Chicago, USA
The Role of Tumor Stroma in Immune Escape of Cancer

Monday, February 08 | 8:00AM - 11:15AM
Tumor Microenvironment and Immune Escape (Joint)
Room: Grays/Longs Peak
This session will be focused on how stromal cells, inflammation, and angiogenesis support malignant progression, highlighting crucial roles for immune cells in contributing to these processes.
Speaker 7 of 7
Esteban Celis, Moffitt Cancer Center, USA
Short Talk: Interferon-gamma Induced T Cell Epitope Purging: Another Mode of Tumor Immune Escape?

Monday, February 08 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, February 08 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, February 08 | 11:15AM - 1:00PM
Poster Setup
Room: Quandary


Monday, February 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary


Monday, February 08 | 2:30PM - 4:30PM
Workshop 1: Regulation of Immune Escape by Microenvironment
Room: Longs Peak
This session will deepen understanding of the critical role of the tumor microenvironment in driving malignant progression.
Speaker 1 of 7
* Dmitry I. Gabrilovich, AstraZeneca, USA

Monday, February 08 | 2:30PM - 4:30PM
Workshop 1: Regulation of Immune Escape by Microenvironment
Room: Longs Peak
This session will deepen understanding of the critical role of the tumor microenvironment in driving malignant progression.
Speaker 2 of 7
Srinivas Nagaraj, University of South Florida, College of Medicine, USA
Regulation of Myeloid-Derived Suppressor Cell Activity in Cancer by CD4+ T Cells

Monday, February 08 | 2:30PM - 4:30PM
Workshop 1: Regulation of Immune Escape by Microenvironment
Room: Longs Peak
This session will deepen understanding of the critical role of the tumor microenvironment in driving malignant progression.
Speaker 3 of 7
Cassie K. Chou, University of Washington, USA
Abrogation of TGFbeta Signaling Leads to Increased Persistence of Prostate Self/Tumor Antigen Specific CD8 T Cells but does not Completely Prevent Tolerization

Monday, February 08 | 2:30PM - 4:30PM
Workshop 1: Regulation of Immune Escape by Microenvironment
Room: Longs Peak
This session will deepen understanding of the critical role of the tumor microenvironment in driving malignant progression.
Speaker 4 of 7
Luca Vago, IRCCS H San Raffaele, Italy
Loss of Mismatched HLA as a Mechanism of Leukemia Immune Escape in Family Haploidentical and Unrelated HSCT

Monday, February 08 | 2:30PM - 4:30PM
Workshop 1: Regulation of Immune Escape by Microenvironment
Room: Longs Peak
This session will deepen understanding of the critical role of the tumor microenvironment in driving malignant progression.
Speaker 5 of 7
Philippe Foubert, Genomics Institute of the Novartis Research Foundation, USA
Blockade of Myeloid Cell Trafficking by Inhibiting a PI3-Kinase gamma-alpha4 Integrin Activation Pathway Stimulates Anti-Tumor Immunity

Monday, February 08 | 2:30PM - 4:30PM
Workshop 1: Regulation of Immune Escape by Microenvironment
Room: Longs Peak
This session will deepen understanding of the critical role of the tumor microenvironment in driving malignant progression.
Speaker 6 of 7
Sheng Wei, Moffitt Cancer Center, USA
Myeloid-Derived Suppressor Cells (MDSC) are Effectors of Bone Marrow Suppression in Lower Risk Myelodysplastic Syndromes (MDS)

Monday, February 08 | 2:30PM - 4:30PM
Workshop 1: Regulation of Immune Escape by Microenvironment
Room: Longs Peak
This session will deepen understanding of the critical role of the tumor microenvironment in driving malignant progression.
Speaker 7 of 7
Michael S. Leibowitz, University of Pittsburgh, USA
TAP1/2 Downregulation and CTL Evasion is Independent of STAT3 Activation in Head and Neck Cancer Cells

Monday, February 08 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, February 08 | 5:00PM - 7:00PM
Antigen-Specific Mechanisms of Tumor Escape
Room: Longs Peak
This session will be focused on molecular and cellular mechanisms associated with role of antigens in tumor escape. Topics include tumor antigen diversity, molecular mechanisms of defective antigen presentation by tumor cells, dendritic cells and T cell tolerance.
Speaker 1 of 5
* Hans Schreiber, University of Chicago, USA

Monday, February 08 | 5:00PM - 7:00PM
Antigen-Specific Mechanisms of Tumor Escape
Room: Longs Peak
This session will be focused on molecular and cellular mechanisms associated with role of antigens in tumor escape. Topics include tumor antigen diversity, molecular mechanisms of defective antigen presentation by tumor cells, dendritic cells and T cell tolerance.
Speaker 2 of 5
Thomas Blankenstein, Max Delbruck Center for Molecular Medicine, Germany
No Escape

Monday, February 08 | 5:00PM - 7:00PM
Antigen-Specific Mechanisms of Tumor Escape
Room: Longs Peak
This session will be focused on molecular and cellular mechanisms associated with role of antigens in tumor escape. Topics include tumor antigen diversity, molecular mechanisms of defective antigen presentation by tumor cells, dendritic cells and T cell tolerance.
Speaker 3 of 5
Michael R. Shurin, University of Pittsburgh, USA
Dendritic Cells in Immune Escape in Cancer

Monday, February 08 | 5:00PM - 7:00PM
Antigen-Specific Mechanisms of Tumor Escape
Room: Longs Peak
This session will be focused on molecular and cellular mechanisms associated with role of antigens in tumor escape. Topics include tumor antigen diversity, molecular mechanisms of defective antigen presentation by tumor cells, dendritic cells and T cell tolerance.
Speaker 4 of 5
Richard A. Flavell, HHMI/Yale University School of Medicine, USA
TGF-beta Signaling in Tumoral Immune Suppression

Monday, February 08 | 5:00PM - 7:00PM
Antigen-Specific Mechanisms of Tumor Escape
Room: Longs Peak
This session will be focused on molecular and cellular mechanisms associated with role of antigens in tumor escape. Topics include tumor antigen diversity, molecular mechanisms of defective antigen presentation by tumor cells, dendritic cells and T cell tolerance.
Speaker 5 of 5
Andrew D.M. Kaiser, Netherlands Cancer Institute, Netherlands
Short Talk: Low Tumor-Antigen Density Leads to PD-L1/PD-1 Mediated Suppression of Partially Exhausted CD8+ T Cells

Monday, February 08 | 5:00PM - 7:00PM
Inflammation in the Tumor Microenvironment
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 1 of 4
* Frances R. Balkwill, Barts Cancer Institute, Queen Mary University of London, UK


Monday, February 08 | 5:00PM - 7:00PM
Inflammation in the Tumor Microenvironment
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 2 of 4
Alberto Mantovani, Humanitas University, Italy
Tumor Microenvironment: Sculpting the Inflammatory Response during Tumor Formation


Monday, February 08 | 5:00PM - 7:00PM
Inflammation in the Tumor Microenvironment
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 3 of 4
Susan E. Erdman, Massachusetts Institute of Technology, USA
Unifying Roles for Regulatory T Cells and Inflammation in Cancer


Monday, February 08 | 5:00PM - 7:00PM
Inflammation in the Tumor Microenvironment
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 4 of 4
Michele W. Teng, QIMR Berghofer Medical Research Institute, Australia
IL-23 Suppresses Innate Immune Response during Carcinogenesis and Metastasis


Monday, February 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary


Monday, February 08 | 7:30PM - 10:00PM
Poster Session 1
Room: Quandary


Tuesday, February 09 | 7:00AM - 8:00AM
Breakfast
Room: Quandary


Tuesday, February 09 | 8:00AM - 11:15AM
Myeloid Cells in Immune Suppression and Tumor Progression
Room: Longs Peak
This session will focus on the molecular and cellular mechanisms of immunosuppression by different types of myeloid cells.
Speaker 1 of 9
* Mario P. Colombo, Fondazione IRCCS Istituto Nazionale Tumori, Italy

Tuesday, February 09 | 8:00AM - 11:15AM
Myeloid Cells in Immune Suppression and Tumor Progression
Room: Longs Peak
This session will focus on the molecular and cellular mechanisms of immunosuppression by different types of myeloid cells.
Speaker 2 of 9
Dmitry I. Gabrilovich, AstraZeneca, USA
Regulation of Myeloid-Derived Suppressor Cells in Cancer

Tuesday, February 09 | 8:00AM - 11:15AM
Myeloid Cells in Immune Suppression and Tumor Progression
Room: Longs Peak
This session will focus on the molecular and cellular mechanisms of immunosuppression by different types of myeloid cells.
Speaker 3 of 9
David H. Munn, Georgia Regents University, USA
Indoleamine 2,3-Dioxygenase in Tumor Immune Escape

Tuesday, February 09 | 8:00AM - 11:15AM
Myeloid Cells in Immune Suppression and Tumor Progression
Room: Longs Peak
This session will focus on the molecular and cellular mechanisms of immunosuppression by different types of myeloid cells.
Speaker 4 of 9
David R. Gibb, Virginia Commonwealth University, USA
and

Tuesday, February 09 | 8:00AM - 11:15AM
Myeloid Cells in Immune Suppression and Tumor Progression
Room: Longs Peak
This session will focus on the molecular and cellular mechanisms of immunosuppression by different types of myeloid cells.
Speaker 5 of 9
Sheinei Jamal Saleem, Virginia Commonwealth University, USA
Short Talk: A Novel Model of Myeloid-Derived Suppression of the Anti-Tumor Response: Overexpression of ADAM10 Promotes Myeloid-Derived Suppressor Cell Expansion in a Tumor-Free Environment

Tuesday, February 09 | 8:00AM - 11:15AM
Myeloid Cells in Immune Suppression and Tumor Progression
Room: Longs Peak
This session will focus on the molecular and cellular mechanisms of immunosuppression by different types of myeloid cells.
Speaker 6 of 9
Vincenzo Bronte, University of Verona, Italy
Forced Myelopoiesis and Immune Deviation in Cancer

Tuesday, February 09 | 8:00AM - 11:15AM
Myeloid Cells in Immune Suppression and Tumor Progression
Room: Longs Peak
This session will focus on the molecular and cellular mechanisms of immunosuppression by different types of myeloid cells.
Speaker 7 of 9
Ling Qi, Cornell University, USA
Short Talk: The Metabolic Function of Myeloid-Derived Suppressor Cells in Obesity

Tuesday, February 09 | 8:00AM - 11:15AM
Myeloid Cells in Immune Suppression and Tumor Progression
Room: Longs Peak
This session will focus on the molecular and cellular mechanisms of immunosuppression by different types of myeloid cells.
Speaker 8 of 9
Cong Yan, Indiana University School of Medicine, USA
Short Talk: Apoptotic Inhibition of Myeloid Cells Causes MDSC Expansion and Lung Tumorigenesis

Tuesday, February 09 | 8:00AM - 11:15AM
Myeloid Cells in Immune Suppression and Tumor Progression
Room: Longs Peak
This session will focus on the molecular and cellular mechanisms of immunosuppression by different types of myeloid cells.
Speaker 9 of 9
Anna Wasiuk, Oregon Health & Science University, USA
Short Talk: Mast Cells as Regulators of Adaptive Immunity to Tumors

Tuesday, February 09 | 8:00AM - 11:15AM
Inflammation and Carcinogenesis
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 1 of 7
* Alberto Mantovani, Humanitas University, Italy


Tuesday, February 09 | 8:00AM - 11:15AM
Inflammation and Carcinogenesis
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 2 of 7
Eva M. Hernando, New York University Cancer Center, USA
miRNAs that Contribute to Melanoma Metastasis by Modulating Immune Evasion


Tuesday, February 09 | 8:00AM - 11:15AM
Inflammation and Carcinogenesis
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 3 of 7
Yinling Hu, NCI, National Institutes of Health, USA
Role of IKKalpha in Skin Cancer


Tuesday, February 09 | 8:00AM - 11:15AM
Inflammation and Carcinogenesis
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 4 of 7
Pauline M. Andreu, University of California San Francisco, USA
Short Talk: FcRgamma Activation Regulates Inflammation-Associated Squamous Carcinogenesis


Tuesday, February 09 | 8:00AM - 11:15AM
Inflammation and Carcinogenesis
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 5 of 7
Giorgio Trinchieri, NCI, National Institutes of Health, USA
Innate Resistance and Cancerogenesis


Tuesday, February 09 | 8:00AM - 11:15AM
Inflammation and Carcinogenesis
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 6 of 7
Carlos Bais, Genentech, Inc., USA
Stromal Cells and VEGF-Independent Angiogenesis


Tuesday, February 09 | 8:00AM - 11:15AM
Inflammation and Carcinogenesis
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 7 of 7
Brendan J. Jenkins, Hudson Institute of Medical Research, Australia
Short Talk: Deregulated Cytokine Signaling as a Crucial Bridge Linking Pathogen-Driven Gastric Inflammation and Tumorigenesis


Tuesday, February 09 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, February 09 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, February 09 | 11:15AM - 1:00PM
Poster Setup
Room: Quandary


Tuesday, February 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary


Tuesday, February 09 | 2:30PM - 4:30PM
Workshop: Inflammation and Carcinogenesis
This session is from Cancer and Inflammation
Room: Grays Peak
This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment.
Speaker 1 of 10
* Jacqueline F. Bromberg, Memorial Sloan Kettering Cancer Center, USA


Tuesday, February 09 | 2:30PM - 4:30PM
Workshop: Inflammation and Carcinogenesis
This session is from Cancer and Inflammation
Room: Grays Peak
This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment.
Speaker 2 of 10
* Carlos Bais, Genentech, Inc., USA


Tuesday, February 09 | 2:30PM - 4:30PM
Workshop: Inflammation and Carcinogenesis
This session is from Cancer and Inflammation
Room: Grays Peak
This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment.
Speaker 3 of 10
David G. DeNardo, Washington University Medical School, USA
CD4+ T Lymphocytes Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing the Pro-Tumor Properties of Macrophages


Tuesday, February 09 | 2:30PM - 4:30PM
Workshop: Inflammation and Carcinogenesis
This session is from Cancer and Inflammation
Room: Grays Peak
This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment.
Speaker 4 of 10
Mercedes B. Fuertes, University of Chicago, USA
Host Type I IFN Signals Mediate Awareness of Tumor and Promote Spontaneous Adaptive Immune Responses Against Tumor-Associated Antigens


Tuesday, February 09 | 2:30PM - 4:30PM
Workshop: Inflammation and Carcinogenesis
This session is from Cancer and Inflammation
Room: Grays Peak
This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment.
Speaker 5 of 10
Esther N. Arwert, Francis Crick Institute, UK
Tumor Formation Initiated by Nondividing Epidermal Cells via an Inflammatory Infiltrate


Tuesday, February 09 | 2:30PM - 4:30PM
Workshop: Inflammation and Carcinogenesis
This session is from Cancer and Inflammation
Room: Grays Peak
This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment.
Speaker 6 of 10
Jack D. Bui, University of California, San Diego, USA
Evidence for Macrophage-Mediated Cancer Immunoediting


Tuesday, February 09 | 2:30PM - 4:30PM
Workshop: Inflammation and Carcinogenesis
This session is from Cancer and Inflammation
Room: Grays Peak
This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment.
Speaker 7 of 10
Sharon A. Glynn, National University of Ireland Galway, Ireland
Joint Expression of NOS2 and COX2 in ER-Negative Breast Cancer – Acquisition of a Poor Prognosis Phenotype


Tuesday, February 09 | 2:30PM - 4:30PM
Workshop: Inflammation and Carcinogenesis
This session is from Cancer and Inflammation
Room: Grays Peak
This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment.
Speaker 8 of 10
Abby L. Geis, Arkansas College of Osteopathic Medicine, USA
A Human Commensal Promotes Colorectal Cancer in Min Mice: Role of the Treg / Th17 Balance in the colitis-Induced Carcinogenesis


Tuesday, February 09 | 2:30PM - 4:30PM
Workshop: Inflammation and Carcinogenesis
This session is from Cancer and Inflammation
Room: Grays Peak
This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment.
Speaker 9 of 10
Maria Grazia Ruocco, Skirball, New York University School of Medicine, USA
Stress-Induced Signals Facilitate T Cell Arrest and Lead to Tumor Eradication


Tuesday, February 09 | 2:30PM - 4:30PM
Workshop: Inflammation and Carcinogenesis
This session is from Cancer and Inflammation
Room: Grays Peak
This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment.
Speaker 10 of 10
Li Yang, NCI, National Institutes of Health, USA
Short Talk: TGFbeta, an Inflammation and Immune Suppressor in Tumor Progression


Tuesday, February 09 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, February 09 | 5:00PM - 7:00PM
Regulatory T and NKT Cells in Immune Escape
Room: Longs Peak
This session is focused on molecular and cellular mechanisms of regulatory T cell function in cancers. Specific topics can include novel findings on the role of classical Treg in cancer, different types of Tregs, and role of NKT.
Speaker 1 of 5
* Vincenzo Bronte, University of Verona, Italy

Tuesday, February 09 | 5:00PM - 7:00PM
Regulatory T and NKT Cells in Immune Escape
Room: Longs Peak
This session is focused on molecular and cellular mechanisms of regulatory T cell function in cancers. Specific topics can include novel findings on the role of classical Treg in cancer, different types of Tregs, and role of NKT.
Speaker 2 of 5
Harald von Boehmer, Harvard Medical School, USA
In vivo Induction of Antigen-Specific Regulatory T Cells to Prevent Unwanted Immunity

Tuesday, February 09 | 5:00PM - 7:00PM
Regulatory T and NKT Cells in Immune Escape
Room: Longs Peak
This session is focused on molecular and cellular mechanisms of regulatory T cell function in cancers. Specific topics can include novel findings on the role of classical Treg in cancer, different types of Tregs, and role of NKT.
Speaker 3 of 5
Rong-Fu Wang, Baylor College of Medicine, USA
Immunosuppressive gammadelta Treg and other Immune Cells and their Functional Regulation through Innate Immune Signaling

Tuesday, February 09 | 5:00PM - 7:00PM
Regulatory T and NKT Cells in Immune Escape
Room: Longs Peak
This session is focused on molecular and cellular mechanisms of regulatory T cell function in cancers. Specific topics can include novel findings on the role of classical Treg in cancer, different types of Tregs, and role of NKT.
Speaker 4 of 5
Mario P. Colombo, Fondazione IRCCS Istituto Nazionale Tumori, Italy
OX40 Costimulation in Treg Functions

Tuesday, February 09 | 5:00PM - 7:00PM
Regulatory T and NKT Cells in Immune Escape
Room: Longs Peak
This session is focused on molecular and cellular mechanisms of regulatory T cell function in cancers. Specific topics can include novel findings on the role of classical Treg in cancer, different types of Tregs, and role of NKT.
Speaker 5 of 5
Jay A. Berzofsky, NCI, National Institutes of Health, USA
Short Talk: Tipping the Balance in the NKT Cell Regulation of Tumor Immunity

Tuesday, February 09 | 5:00PM - 7:00PM
Innate Resistance and Tumor Escape
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 1 of 4
* Nina Bhardwaj, Icahn School of Medicine at Mount Sinai, USA


Tuesday, February 09 | 5:00PM - 7:00PM
Innate Resistance and Tumor Escape
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 2 of 4
David H. Raulet, University of California, Berkeley, USA
NKG2D, NKG2D Ligands and Spontaneous Malignancy


Tuesday, February 09 | 5:00PM - 7:00PM
Innate Resistance and Tumor Escape
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 3 of 4
Laurence Zitvogel, Institut Gustave Roussy, France
NKp30/NCR3 Isoforms and Prognosis of Human Malignancies: Revisiting the DC/NK Cross Talk


Tuesday, February 09 | 5:00PM - 7:00PM
Innate Resistance and Tumor Escape
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 4 of 4
Mark J. Smyth, QIMR Berghofer Medical Research Institute, Australia
Suppression and Innate Immune Surveillance


Tuesday, February 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary


Tuesday, February 09 | 7:30PM - 10:00PM
Poster Session 2
Room: Quandary


Wednesday, February 10 | 7:00AM - 8:00AM
Breakfast
Room: Quandary


Wednesday, February 10 | 8:00AM - 11:15AM
Transcriptional Regulation of Immune Escape (Joint)
Room: Grays/Longs Peak
Session will discuss regulation of gene expression implicated in tumor progression and immune escape, including possible modifier effects and relationship to metastastic efficiency.
Speaker 1 of 7
* George C. Prendergast, Lankenau Institute for Medical Research, USA

Wednesday, February 10 | 8:00AM - 11:15AM
Transcriptional Regulation of Immune Escape (Joint)
Room: Grays/Longs Peak
Session will discuss regulation of gene expression implicated in tumor progression and immune escape, including possible modifier effects and relationship to metastastic efficiency.
Speaker 2 of 7
Hua E. Yu, Beckman Research Institute, City of Hope, USA
STAT3 in Cancer Inflammation and Immune Escape

Wednesday, February 10 | 8:00AM - 11:15AM
Transcriptional Regulation of Immune Escape (Joint)
Room: Grays/Longs Peak
Session will discuss regulation of gene expression implicated in tumor progression and immune escape, including possible modifier effects and relationship to metastastic efficiency.
Speaker 3 of 7
Erwin F. Wagner, Spanish National Cancer Research Centre, Spain
Stress-responsive and context dependent transcription factor complex

Wednesday, February 10 | 8:00AM - 11:15AM
Transcriptional Regulation of Immune Escape (Joint)
Room: Grays/Longs Peak
Session will discuss regulation of gene expression implicated in tumor progression and immune escape, including possible modifier effects and relationship to metastastic efficiency.
Speaker 4 of 7
Mitsugu Fujita, University of Pittsburgh Cancer Institute, USA
A Pivotal Role of Type-1 Interferons in Anti-glioma Immunosurveillance

Wednesday, February 10 | 8:00AM - 11:15AM
Transcriptional Regulation of Immune Escape (Joint)
Room: Grays/Longs Peak
Session will discuss regulation of gene expression implicated in tumor progression and immune escape, including possible modifier effects and relationship to metastastic efficiency.
Speaker 5 of 7
Thomas Gajewski, University of Chicago, USA
Transcriptional regulation of T cell anergy: Implications for cancer immunotherapy

Wednesday, February 10 | 8:00AM - 11:15AM
Transcriptional Regulation of Immune Escape (Joint)
Room: Grays/Longs Peak
Session will discuss regulation of gene expression implicated in tumor progression and immune escape, including possible modifier effects and relationship to metastastic efficiency.
Speaker 6 of 7
Michael Karin, University of California, San Diego, USA
Tumor elicited inflammation and lymphocyte infiltrates in metastatic progression

Wednesday, February 10 | 8:00AM - 11:15AM
Transcriptional Regulation of Immune Escape (Joint)
Room: Grays/Longs Peak
Session will discuss regulation of gene expression implicated in tumor progression and immune escape, including possible modifier effects and relationship to metastastic efficiency.
Speaker 7 of 7
Jahan Khalili, MD Anderson Cancer Center, USA
Short Talk: The Role of B-raf V600E Mutation on PD-1 Ligand Expression in Melanocytic nevi

Wednesday, February 10 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 10 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, February 10 | 11:15AM - 1:00PM
Poster Setup
Room: Quandary


Wednesday, February 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary


Wednesday, February 10 | 2:30PM - 4:30PM
Workshop 2: Tumor Recruitment of Immune Cells: Roles in Tumo
r Progression and Immune Escape
Room: Longs Peak
Consider roles for MDSCs, B cells, mast cells, microvesicle transfer, etc.
Speaker 1 of 7
* Michael R. Shurin, University of Pittsburgh, USA

Wednesday, February 10 | 2:30PM - 4:30PM
Workshop 2: Tumor Recruitment of Immune Cells: Roles in Tumo
r Progression and Immune Escape
Room: Longs Peak
Consider roles for MDSCs, B cells, mast cells, microvesicle transfer, etc.
Speaker 2 of 7
Courtney Smith, Lankenau Institute for Medical Research, USA
Indoleamine 2,3-Dioxygenase (IDO) Supports Metastatic Outgrowth of the 4T1 Breast Cancer Mouse Model

Wednesday, February 10 | 2:30PM - 4:30PM
Workshop 2: Tumor Recruitment of Immune Cells: Roles in Tumo
r Progression and Immune Escape
Room: Longs Peak
Consider roles for MDSCs, B cells, mast cells, microvesicle transfer, etc.
Speaker 3 of 7
Melody A. Swartz, University of Chicago, USA
Lymph Node Mimicry by Tumors Promotes Immunological Tolerance

Wednesday, February 10 | 2:30PM - 4:30PM
Workshop 2: Tumor Recruitment of Immune Cells: Roles in Tumo
r Progression and Immune Escape
Room: Longs Peak
Consider roles for MDSCs, B cells, mast cells, microvesicle transfer, etc.
Speaker 4 of 7
Stephanie Watkins, National Cancer Institute, National Institutes of Health, USA
Prostate Tumor-Associated Dendritic Cell Induction of Tolerance and Suppressor Activity in Tumor-Infiltrating CTLs is Associated with FOXO3a Expression

Wednesday, February 10 | 2:30PM - 4:30PM
Workshop 2: Tumor Recruitment of Immune Cells: Roles in Tumo
r Progression and Immune Escape
Room: Longs Peak
Consider roles for MDSCs, B cells, mast cells, microvesicle transfer, etc.
Speaker 5 of 7
Rongcun Yang, Nankai University, China
Suppressor of Cytokine Signaling-3 (SOCS3) Downregulates the Ability of Pyruvate Kinase Type M2 to Cause Dendritic Cell Dysfunction

Wednesday, February 10 | 2:30PM - 4:30PM
Workshop 2: Tumor Recruitment of Immune Cells: Roles in Tumo
r Progression and Immune Escape
Room: Longs Peak
Consider roles for MDSCs, B cells, mast cells, microvesicle transfer, etc.
Speaker 6 of 7
Kyle C. McKenna, University of Pittsburgh, USA
Short Talk: Inhibited Function of Intratumoral F4/80+ Macrophages Contributes to the Failure of CD8+ CTL to Control Ocular Tumor Development

Wednesday, February 10 | 2:30PM - 4:30PM
Workshop 2: Tumor Recruitment of Immune Cells: Roles in Tumo
r Progression and Immune Escape
Room: Longs Peak
Consider roles for MDSCs, B cells, mast cells, microvesicle transfer, etc.
Speaker 7 of 7
Andreas Herrmann, Beckman Research Institute, USA
Short Talk: Stat3 is a Molecular Target for Improving Adoptive T cell Therapy

Wednesday, February 10 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 10 | 5:00PM - 7:00PM
Immune Inhibitory Receptors in Cancer
Room: Longs Peak

Speaker 1 of 6
* Augusto C. Ochoa, Louisiana State University Health Sciences Center, USA

Wednesday, February 10 | 5:00PM - 7:00PM
Immune Inhibitory Receptors in Cancer
Room: Longs Peak

Speaker 2 of 6
Drew M. Pardoll, Johns Hopkins University School of Medicine, USA
Mechanism of T-Cell Tolerance in Cancer Mediated by Inhibitory Receptors

Wednesday, February 10 | 5:00PM - 7:00PM
Immune Inhibitory Receptors in Cancer
Room: Longs Peak

Speaker 3 of 6
Hyam I. Levitsky, Century Therapeutics, USA
Mechanism of T-Cell Tolerance in Cancer

Wednesday, February 10 | 5:00PM - 7:00PM
Immune Inhibitory Receptors in Cancer
Room: Longs Peak

Speaker 4 of 6
Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA
Short Talk: Official title unknown. Topic was IL-35 and its role in regulation of T cell function

Wednesday, February 10 | 5:00PM - 7:00PM
Immune Inhibitory Receptors in Cancer
Room: Longs Peak

Speaker 5 of 6
George Coukos, University Hospital of Lausanne - CHUV, Switzerland
Hypoxia Recruits Regulatory T Cells via the CCL28 Chemokine to Promote Tolerance and Angiogenesis in Cancer

Wednesday, February 10 | 5:00PM - 7:00PM
Immune Inhibitory Receptors in Cancer
Room: Longs Peak

Speaker 6 of 6
Daniel Hirschhorn-Cymerman, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: OX40 Engagement and Chemotherapy Combination Provides Potent Anti-Tumor Immunity with Concomitant Regulatory T Cell Apoptosis

Wednesday, February 10 | 5:00PM - 7:00PM
Innate Receptors, Cancer and Inflammation
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 1 of 5
* Mark J. Smyth, QIMR Berghofer Medical Research Institute, Australia


Wednesday, February 10 | 5:00PM - 7:00PM
Innate Receptors, Cancer and Inflammation
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 2 of 5
Xiaoxia Li, Cleveland Clinic Foundation, USA
SIGIRR-Mediated Tumor Suppression


Wednesday, February 10 | 5:00PM - 7:00PM
Innate Receptors, Cancer and Inflammation
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 3 of 5
Felix Yarovinsky, University of Rochester Medical Center, USA
Short Talk: A Novel Transgenic Mouse Model for Chronic Inflammation: Linking Toll-like Receptor (TLR) Responses with Carcinogenesis


Wednesday, February 10 | 5:00PM - 7:00PM
Innate Receptors, Cancer and Inflammation
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 4 of 5
Nina Linde, German Cancer Research Center (DKFZ), Germany
Inflammation in Epithelial Skin Tumors


Wednesday, February 10 | 5:00PM - 7:00PM
Innate Receptors, Cancer and Inflammation
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 5 of 5
Irving C. Allen, Virginia Tech, USA
Short Talk: NLRP3 is an Essential Regulator of Interleukin-1beta and Interleukin-18 during Inflammation Driven Colon Tumorigenesis


Wednesday, February 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary


Wednesday, February 10 | 7:30PM - 10:00PM
Poster Session 3
Room: Quandary


Thursday, February 11 | 7:00AM - 8:00AM
Breakfast
Room: Quandary


Thursday, February 11 | 8:00AM - 11:15AM
Metabolic Pathways Involved in Immune Escape
Room: Longs Peak
This session will be focused on the role of metabolism of carbohydrates, lipids, arginine, tryptophan, and exosomes in tumor escape.
Speaker 1 of 7
* Drew M. Pardoll, Johns Hopkins University School of Medicine, USA

Thursday, February 11 | 8:00AM - 11:15AM
Metabolic Pathways Involved in Immune Escape
Room: Longs Peak
This session will be focused on the role of metabolism of carbohydrates, lipids, arginine, tryptophan, and exosomes in tumor escape.
Speaker 2 of 7
Gabriel A. Rabinovich, Instituto de Biologia y Medicina Experimental, Argentina
'Turning Sweet' on Immunity: Galectin-Glycan Interactions in T-Cell and Dendritic Cell Physiology

Thursday, February 11 | 8:00AM - 11:15AM
Metabolic Pathways Involved in Immune Escape
Room: Longs Peak
This session will be focused on the role of metabolism of carbohydrates, lipids, arginine, tryptophan, and exosomes in tumor escape.
Speaker 3 of 7
Suzanne Ostrand-Rosenberg, University of Maryland, USA
Myeloid Cells, Inflammation, and Anti-Tumor Immunity: Not an Auspicious Combination

Thursday, February 11 | 8:00AM - 11:15AM
Metabolic Pathways Involved in Immune Escape
Room: Longs Peak
This session will be focused on the role of metabolism of carbohydrates, lipids, arginine, tryptophan, and exosomes in tumor escape.
Speaker 4 of 7
Linglin Yang, University of Maryland, Baltimore County, USA
Short Talk: Indoleamine 2,3-Dioxygenase (IDO) Contributes to Myeloid-Derived Suppressor Cell- Mediated Tumor Suppression through Interleukin-6 Signaling Pathway

Thursday, February 11 | 8:00AM - 11:15AM
Metabolic Pathways Involved in Immune Escape
Room: Longs Peak
This session will be focused on the role of metabolism of carbohydrates, lipids, arginine, tryptophan, and exosomes in tumor escape.
Speaker 5 of 7
Augusto C. Ochoa, Louisiana State University Health Sciences Center, USA
Arginine Depletion by MDSC in vivo, a Mechanism of Tumor Escape

Thursday, February 11 | 8:00AM - 11:15AM
Metabolic Pathways Involved in Immune Escape
Room: Longs Peak
This session will be focused on the role of metabolism of carbohydrates, lipids, arginine, tryptophan, and exosomes in tumor escape.
Speaker 6 of 7
Licia Rivoltini, Fondazione IRCCS Istituto Nazionale Tumori, Italy
Tumor-Derived Microvesicles and Immune Defects in Human Cancer

Thursday, February 11 | 8:00AM - 11:15AM
Metabolic Pathways Involved in Immune Escape
Room: Longs Peak
This session will be focused on the role of metabolism of carbohydrates, lipids, arginine, tryptophan, and exosomes in tumor escape.
Speaker 7 of 7
Jonathan D. Silk, University of Oxford, UK
Short Talk: A Novel Amino Acid Transporter Induced by Expression of Indoleamine 2,3 Dioxygenase in Tumors

Thursday, February 11 | 8:00AM - 11:00AM
Dendritic Cells and Macrophages in Cancer
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 1 of 6
* Laurence Zitvogel, Institut Gustave Roussy, France


Thursday, February 11 | 8:00AM - 11:00AM
Dendritic Cells and Macrophages in Cancer
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 2 of 6
Nina Bhardwaj, Icahn School of Medicine at Mount Sinai, USA
Modulating Inflammatory Dendritic Cell Responses against Cancer


Thursday, February 11 | 8:00AM - 11:00AM
Dendritic Cells and Macrophages in Cancer
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 3 of 6
Shannon J. Turley, Genentech, Inc., USA
Novel Aspects of Tolerance in the Tumor Microenvironment


Thursday, February 11 | 8:00AM - 11:00AM
Dendritic Cells and Macrophages in Cancer
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 4 of 6
Miriam Merad, Mount Sinai School of Medicine, USA
Identification of a DC lineage with unique functions in tissues immunity


Thursday, February 11 | 8:00AM - 11:00AM
Dendritic Cells and Macrophages in Cancer
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 5 of 6
Ana Carrizosa Anderson, Harvard Medical School, USA
New Roles for TIM Family Members in Immune Regulation


Thursday, February 11 | 8:00AM - 11:00AM
Dendritic Cells and Macrophages in Cancer
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 6 of 6
Emmanuelle Godefroy, New York University, School of Medicine, USA
Short Talk: MMP-2 Conditions Dendritic Cells to Prime Inflammatory TH2 Cells via an IL-12 and OX40L-Dependent Pathway


Thursday, February 11 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, February 11 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Thursday, February 11 | 2:30PM - 4:30PM
Workshop 3: Novel Strategies to Reverse Immune Escape in Can
cer
Room: Longs Peak
Will discuss novel approaches to reversal of immune defects in cancer. Topics may include cytokines supporting productive immune response, block of inhibitory cytokines and receptors, regulation of immune responses via toll-like receptors, etc.
Speaker 1 of 6
Juan R. Cubillos-Ruiz, Weill Cornell Medical College, USA
siRNA Delivery through Novel TLR5-Agonist Polyethylenimine Reprograms Tumor-Associated Regulatory Dendritic Cells to Elicit Therapeutic Immunity

Thursday, February 11 | 2:30PM - 4:30PM
Workshop 3: Novel Strategies to Reverse Immune Escape in Can
cer
Room: Longs Peak
Will discuss novel approaches to reversal of immune defects in cancer. Topics may include cytokines supporting productive immune response, block of inhibitory cytokines and receptors, regulation of immune responses via toll-like receptors, etc.
Speaker 2 of 6
Viktor Umansky, German Cancer Research Center, Germany
Blocking of Myeloid Derived Suppressor Cell (MDSC) Functions Results in Antitumor Effects in Ret Transgenic Mouse Melanoma Model

Thursday, February 11 | 2:30PM - 4:30PM
Workshop 3: Novel Strategies to Reverse Immune Escape in Can
cer
Room: Longs Peak
Will discuss novel approaches to reversal of immune defects in cancer. Topics may include cytokines supporting productive immune response, block of inhibitory cytokines and receptors, regulation of immune responses via toll-like receptors, etc.
Speaker 3 of 6
Xiangdong Liu, Incyte Corporation, USA
INCB24360, a Potent and Selective Inhibitor of Indoleamine 2,3-dioxygenase (IDO) for Cancer Immunotherapy

Thursday, February 11 | 2:30PM - 4:30PM
Workshop 3: Novel Strategies to Reverse Immune Escape in Can
cer
Room: Longs Peak
Will discuss novel approaches to reversal of immune defects in cancer. Topics may include cytokines supporting productive immune response, block of inhibitory cytokines and receptors, regulation of immune responses via toll-like receptors, etc.
Speaker 4 of 6
Ge Ma, Mount Sinai School of Medicine, USA
Paired Immunoglobin Like Receptor-B (PIRB) Regulates the Suppressive Function and M1 versus M2 Differentiation of MDSC

Thursday, February 11 | 2:30PM - 4:30PM
Workshop 3: Novel Strategies to Reverse Immune Escape in Can
cer
Room: Longs Peak
Will discuss novel approaches to reversal of immune defects in cancer. Topics may include cytokines supporting productive immune response, block of inhibitory cytokines and receptors, regulation of immune responses via toll-like receptors, etc.
Speaker 5 of 6
Carl E. Ruby, Rush University Medical Center, USA
Characterizing the Effect of Aging in Tumor-Bearing Hosts Treated with OX40 Agonists

Thursday, February 11 | 2:30PM - 4:30PM
Workshop 3: Novel Strategies to Reverse Immune Escape in Can
cer
Room: Longs Peak
Will discuss novel approaches to reversal of immune defects in cancer. Topics may include cytokines supporting productive immune response, block of inhibitory cytokines and receptors, regulation of immune responses via toll-like receptors, etc.
Speaker 6 of 6
Thorbald van Hall, Leiden University Medical Center, Netherlands
A Novel Category of Tumor Antigens Enable CTL Immunity to Tumor Escape Variants

Thursday, February 11 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, February 11 | 5:00PM - 7:15PM
Therapeutic Development to Correct Immune Escape in Cancer
Room: Longs Peak
This session will discuss preclinical and clinical development of different approaches to counter immune suppressive mechanisms in cancer.
Speaker 1 of 6
* Hyam I. Levitsky, Century Therapeutics, USA

Thursday, February 11 | 5:00PM - 7:15PM
Therapeutic Development to Correct Immune Escape in Cancer
Room: Longs Peak
This session will discuss preclinical and clinical development of different approaches to counter immune suppressive mechanisms in cancer.
Speaker 2 of 6
Alexander J. Muller, Lankenau Institute for Medical Research, USA
Short Talk: IDO Contributes to Pathologies Associated with Chronic Inflammation

Thursday, February 11 | 5:00PM - 7:15PM
Therapeutic Development to Correct Immune Escape in Cancer
Room: Longs Peak
This session will discuss preclinical and clinical development of different approaches to counter immune suppressive mechanisms in cancer.
Speaker 3 of 6
George C. Prendergast, Lankenau Institute for Medical Research, USA
Regulation and Therapeutic Inhibition of IDO/IDO2 in Cancer

Thursday, February 11 | 5:00PM - 7:15PM
Therapeutic Development to Correct Immune Escape in Cancer
Room: Longs Peak
This session will discuss preclinical and clinical development of different approaches to counter immune suppressive mechanisms in cancer.
Speaker 4 of 6
Jedd D. Wolchok, Memorial Sloan Kettering Cancer Center, USA
The Whys and Wherefores of CTLA-4 Blockade

Thursday, February 11 | 5:00PM - 7:15PM
Therapeutic Development to Correct Immune Escape in Cancer
Room: Longs Peak
This session will discuss preclinical and clinical development of different approaches to counter immune suppressive mechanisms in cancer.
Speaker 5 of 6
Suzanne L. Topalian, Johns Hopkins University School of Medicine, USA
Modulating Anti-tumor Immunity through Checkpoint Blockade: B7-H1/PD-1 Interactions

Thursday, February 11 | 5:00PM - 7:15PM
Therapeutic Development to Correct Immune Escape in Cancer
Room: Longs Peak
This session will discuss preclinical and clinical development of different approaches to counter immune suppressive mechanisms in cancer.
Speaker 6 of 6
Jeffrey Weber, New York University, USA
Regulation of Immune Responses in Cancer via Checkpoint Blockade of Negative Receptors in Melanoma

Thursday, February 11 | 5:00PM - 7:00PM
Cytokines in the Tumor Microenvironment
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 1 of 6
* Giorgio Trinchieri, NCI, National Institutes of Health, USA


Thursday, February 11 | 5:00PM - 7:00PM
Cytokines in the Tumor Microenvironment
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 2 of 6
Jacqueline F. Bromberg, Memorial Sloan Kettering Cancer Center, USA
The IL-6/Stat3 Signaling Pathway Promotes Mammary Tumorigenesis and Metastases


Thursday, February 11 | 5:00PM - 7:00PM
Cytokines in the Tumor Microenvironment
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 3 of 6
Martin Oft, ARMO BioSciences, USA
Switching Tumor Promoting Inflammation into Tumor Immune Surveillance


Thursday, February 11 | 5:00PM - 7:00PM
Cytokines in the Tumor Microenvironment
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 4 of 6
Charles G. Drake, Columbia University, USA
Th17 Cells in Tumors


Thursday, February 11 | 5:00PM - 7:00PM
Cytokines in the Tumor Microenvironment
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 5 of 6
Jiyoung Park, Ulsan National Institute of Science and Technology, South Korea
Short Talk: Peripheral Leptin Promotes Mammary Tumor Progression and Metastasis through Activation of the Jak2/STAT3 Pathway in vivo


Thursday, February 11 | 5:00PM - 7:00PM
Cytokines in the Tumor Microenvironment
This session is from Cancer and Inflammation
Room: Grays Peak

Speaker 6 of 6
Alexander J. Muller, Lankenau Institute for Medical Research, USA
Short Talk: IDO Contributes to Pathologies Associated with Chronic Inflammation


Thursday, February 11 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Quandary


Thursday, February 11 | 8:15PM - 11:00PM
Entertainment
Room: Quandary


Thursday, February 11 | 8:15PM - 11:00PM
Cash Bar
Room: Quandary


Friday, February 12 | 10:25AM - 10:25AM
Departure


*Session Chair.