Web Desc
Telomere Biology and DNA Repair
Organizer(s): Roger R. Reddel, Michael B. Kastan and Titia de Lange
Date: October 09 - 14, 2009
Location: RACV Royal Pines Resort, Ashmore, Queensland, Australia
Supported by The Directors' Fund
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Summary of Meeting:
There is emerging evidence that telomere dysfunction has ramifications in a wide range of pathologies including cancer, bone marrow failure, pulmonary fibrosis and diseases of aging. Telomeric DNA poses special problems for the DNA repair machinery. The ends of telomeres need to avoid being recognized as DNA breaks and thereby avoid being subjected to DNA repair events that may lead to chromosome end-to-end fusions and result in chromosomal instability. The proteins that bind to telomeres and the higher order telomeric structures that protect the ends from repair events are of particular interest. Another special biological problem is posed by the gradual shortening of telomeres that occurs in somatic cells. Excessively short telomeres may trigger DNA damage checkpoints and be substrates for DNA repair reactions, and the similarities and differences between these processes at telomeres and elsewhere in the genome require examination. The role of DNA repair proteins that are present at normally functioning telomeres, and the possible role of telomere binding proteins elsewhere in the genome is of particular interest. This meeting will explore these and other exciting areas of convergence in the fields of telomere biology and DNA repair.
Scholarship Deadline: June 10 2009
Discounted Abstract Deadline: June 10 2009
Abstract Deadline: July 13 2009
Discounted Registration Deadline: August 10 2009
Late Abstracts


We gratefully acknowledge additional support for this conference from:
CSIROThe Queensland Government, through the Department of Employment, Economic Development and Innovation
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
AusBiotechAustralian and New Zealand Society for Cell and Developmental BiologyAustralian Society for Biochemistry & Molecular BiologyGold Coast Convention Bureau
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Environmental Health Sciences (NIEHS)
Grant No. 1R13ES017583-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, October 09 | 3:00PM - 7:00PM
Registration
Room: Marquis Foyer


Saturday, October 10 | 7:30AM - 8:30AM
Breakfast
Room: Kalinda Restaurant


Saturday, October 10 | 8:30AM - 9:30AM
Keynote Address
Room: Marquis Room

Speaker 1 of 2
* Michael B. Kastan, St. Jude Children's Research Hospital, USA

Saturday, October 10 | 8:30AM - 9:30AM
Keynote Address
Room: Marquis Room

Speaker 2 of 2
Stephen C. West, Francis Crick Institute, UK
Defects in DNA Strand Break Repair and Links to Inheritable Disease

Saturday, October 10 | 9:30AM - 12:30PM
DNA Damage Sensing and Signaling 1
Room: Marquis Room

Speaker 1 of 5
* Alan D. D'Andrea, Dana-Farber Cancer Institute, USA

Saturday, October 10 | 9:30AM - 12:30PM
DNA Damage Sensing and Signaling 1
Room: Marquis Room

Speaker 2 of 5
Martin F. Lavin, Queensland Institute for Medical Research, Australia
DNA Damage Signaling through the MRN Complex

Saturday, October 10 | 9:30AM - 12:30PM
DNA Damage Sensing and Signaling 1
Room: Marquis Room

Speaker 3 of 5
Roger Greenberg, University of Pennsylvania, USA
Ubiquitin Recognition and Remodeling at DNA Double Strand Breaks

Saturday, October 10 | 9:30AM - 12:30PM
DNA Damage Sensing and Signaling 1
Room: Marquis Room

Speaker 4 of 5
David Faucher, Universite de Sherbrooke, Canada
Short Talk: Methylated H3K4, a Transcription Associated Histone Modification, is Involved in the DNA Damage Response Pathway

Saturday, October 10 | 9:30AM - 12:30PM
DNA Damage Sensing and Signaling 1
Room: Marquis Room

Speaker 5 of 5
Jiri Lukas, Novo Nordisk Foundation Center for Protein Research, Denmark
Dynamic Organization of the DNA Damage Response in Space and Time

Saturday, October 10 | 9:50AM - 10:10AM
Coffee Break
Room: Marquis Foyer


Saturday, October 10 | 12:30PM - 1:30PM
Poster Setup
Room: Monarch Room


Saturday, October 10 | 1:30PM - 10:00PM
Poster Viewing
Room: Monarch Room


Saturday, October 10 | 4:30PM - 5:00PM
Coffee Available
Room: Marquis Foyer


Saturday, October 10 | 5:00PM - 7:00PM
Telomeres and DNA Damage Response
Room: Marquis Room

Speaker 1 of 6
* Roger R. Reddel, Children’s Medical Research Institute, Sydney, Australia

Saturday, October 10 | 5:00PM - 7:00PM
Telomeres and DNA Damage Response
Room: Marquis Room

Speaker 2 of 6
Michael B. Kastan, St. Jude Children's Research Hospital, USA
ATM-Dependent DNA Damage Signaling

Saturday, October 10 | 5:00PM - 7:00PM
Telomeres and DNA Damage Response
Room: Marquis Room

Speaker 3 of 6
Titia de Lange, Rockefeller University, USA
Persistent Telomere Damage Induces By-Pass of Mitosis and Tetraploidy

Saturday, October 10 | 5:00PM - 7:00PM
Telomeres and DNA Damage Response
Room: Marquis Room

Speaker 4 of 6
Fuyuki Ishikawa, Kyoto University, Japan
RPA-like Mammalian Ctc1-Stn1-Ten1 Complex Binds to Single-Stranded DNA and Protects Telomeres Independently of the Pot1 Pathway

Saturday, October 10 | 5:00PM - 7:00PM
Telomeres and DNA Damage Response
Room: Marquis Room

Speaker 5 of 6
Eric Gilson, Université de Lyon, France
TRF2 and Apollo Protect the Inner Part of Human Telomeres
from Replicative Damages


Saturday, October 10 | 5:00PM - 7:00PM
Telomeres and DNA Damage Response
Room: Marquis Room

Speaker 6 of 6
Amy D. Gelinas, University of Colorado at Boulder, USA
Short Talk: Telomere Capping Proteins are Structurally Related to RPA

Saturday, October 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Monarch Room


Saturday, October 10 | 7:30PM - 10:00PM
Poster Session 1
Room: Monarch Room


Sunday, October 11 | 7:30AM - 8:30AM
Breakfast
Room: Kalinda Restaurant


Sunday, October 11 | 7:30AM - 8:30AM
Poster Setup
Room: Monarch Room


Sunday, October 11 | 8:00AM - 5:30PM
Poster Viewing
Room: Monarch Room


Sunday, October 11 | 8:30AM - 11:30AM
DNA Repair 1
Room: Marquis Room

Speaker 1 of 6
* Jan Karlseder, The Salk Institute for Biological Studies, USA

Sunday, October 11 | 8:30AM - 11:30AM
DNA Repair 1
Room: Marquis Room

Speaker 2 of 6
Alan D. D'Andrea, Dana-Farber Cancer Institute, USA
The Fanconi Anemia Pathway and the DNA Damage Response

Sunday, October 11 | 8:30AM - 11:30AM
DNA Repair 1
Room: Marquis Room

Speaker 3 of 6
Camilla Sjögren, Karolinska Institutet, Sweden
The SMC5/6 Complex – More than Repair?

Sunday, October 11 | 8:30AM - 11:30AM
DNA Repair 1
Room: Marquis Room

Speaker 4 of 6
Judith L. Campbell, California Institute of Technology, USA
Short Talk: The Roles of Yeast and Human Dna2 in Nuclear DNA DSB Repair and Telomere

Sunday, October 11 | 8:30AM - 11:30AM
DNA Repair 1
Room: Marquis Room

Speaker 5 of 6
Maria Jasin, Memorial Sloan Kettering Cancer Center, USA
Double Strand Break Repair Pathways

Sunday, October 11 | 8:30AM - 11:30AM
DNA Repair 1
Room: Marquis Room

Speaker 6 of 6
Jörg Heierhorst, St. Vincent's Institute of Medical Research, Australia
Short Talk: Role of the Rad53 SQ/TQ Cluster Domain as a Phospho-Counting Switch in the DNA Damage Response

Sunday, October 11 | 9:50AM - 10:10AM
Coffee Break
Room: Marquis Foyer


Sunday, October 11 | 11:30AM - 12:30PM
Lunch
Room: Monarch Room


Sunday, October 11 | 12:30PM - 3:00PM
Poster Session 2
Room: Monarch Room


Sunday, October 11 | 3:00PM - 3:30PM
Coffee Available
Room: Marquis Foyer


Sunday, October 11 | 3:30PM - 5:30PM
BIR and ALT
Room: Marquis Room

Speaker 1 of 5
* Maria Jasin, Memorial Sloan Kettering Cancer Center, USA

Sunday, October 11 | 3:30PM - 5:30PM
BIR and ALT
Room: Marquis Room

Speaker 2 of 5
Peter M. Burgers, Washington University School of Medicine, USA
A Tale of Two Tails: Activation of the Mec1/ATR Checkpoint Kinase by 9-1-1 and by Dpb11/TopBp1

Sunday, October 11 | 3:30PM - 5:30PM
BIR and ALT
Room: Marquis Room

Speaker 3 of 5
Michael J. McEachern, University of Georgia, USA
Studies of Telomere Maintenance in the ALT-like stn1-M1 Mutant of Kluyveromyces lactis

Sunday, October 11 | 3:30PM - 5:30PM
BIR and ALT
Room: Marquis Room

Speaker 4 of 5
Roger R. Reddel, Children’s Medical Research Institute, Sydney, Australia
ALT-like Activity in Normal Mammalian Somatic Cells In Vivo

Sunday, October 11 | 3:30PM - 5:30PM
BIR and ALT
Room: Marquis Room

Speaker 5 of 5
Hyunsook Lee, Seoul National University, South Korea
Short Talk: BRCA2 is Involved in Telomere End Protection through Suppression of ALT-like Telomeric Recombination

Sunday, October 11 | 5:30PM - 5:30PM
On Own for Dinner


Monday, October 12 | 7:30AM - 8:30AM
Breakfast
Room: Kalinda Restaurant


Monday, October 12 | 8:30AM - 11:30AM
Telomerase/Control of Telomerase
Room: Marquis Room

Speaker 1 of 7
* Titia de Lange, Rockefeller University, USA

Monday, October 12 | 8:30AM - 11:30AM
Telomerase/Control of Telomerase
Room: Marquis Room

Speaker 2 of 7
Steven E. Artandi, Stanford University, USA
Telomerase Assembly, Telomere Synthesis and Wnt Signaling

Monday, October 12 | 8:30AM - 11:30AM
Telomerase/Control of Telomerase
Room: Marquis Room

Speaker 3 of 7
Raymund J. Wellinger, University of Sherbrooke, Canada
Adaptation to Telomere Uncapping in Yeast

Monday, October 12 | 8:30AM - 11:30AM
Telomerase/Control of Telomerase
Room: Marquis Room

Speaker 4 of 7
Prabhat Khadka, NIH, USA
Short Talk: KIP Modulates Telomerase Activity through Interaction with TRF2

Monday, October 12 | 8:30AM - 11:30AM
Telomerase/Control of Telomerase
Room: Marquis Room

Speaker 5 of 7
Virginia A. Zakian, Princeton University, USA
The Role of the Pif1 DNA Helicase in Maintaining Telomere Length

Monday, October 12 | 8:30AM - 11:30AM
Telomerase/Control of Telomerase
Room: Marquis Room

Speaker 6 of 7
Martina M. Stagno d'Alcontres, Centro Nacional de Investigaciones Oncologicas, Spain
Short Talk: TPP1 Recruits TERT to Chromatin and Positively Regulates Telomere Length, Maintains Telomere Integrity and Prevents Premature Development of Degenerative Pathologies in Mice

Monday, October 12 | 8:30AM - 11:30AM
Telomerase/Control of Telomerase
Room: Marquis Room

Speaker 7 of 7
Ken Masutomi, National Cancer Center, Japan
Short Talk: A Mammalian RNA Dependent RNA Polymerase Formed by hTERT and the RNA Component of RNase MRP

Monday, October 12 | 9:50AM - 10:10AM
Coffee Break
Room: Marquis Foyer


Monday, October 12 | 11:30AM - 1:00PM
Poster Setup
Room: Monarch Room


Monday, October 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Monarch Room


Monday, October 12 | 4:30PM - 5:00PM
Coffee Available
Room: Marquis Foyer


Monday, October 12 | 5:00PM - 7:15PM
DNA Damage Sensing and Signaling 2
Room: Marquis Room

Speaker 1 of 6
* Virginia A. Zakian, Princeton University, USA

Monday, October 12 | 5:00PM - 7:15PM
DNA Damage Sensing and Signaling 2
Room: Marquis Room

Speaker 2 of 6
Junjie Chen, University of Texas MD Anderson Cancer Center, USA
DNA Damage Signaling and DNA Repair

Monday, October 12 | 5:00PM - 7:15PM
DNA Damage Sensing and Signaling 2
Room: Marquis Room

Speaker 3 of 6
Amanda Wraith Kijas, Queensland Institute of Medical Research, Australia
Short Talk: Autophosphorylation and ATM Activation: Additional Sites Add to the Complexity

Monday, October 12 | 5:00PM - 7:15PM
DNA Damage Sensing and Signaling 2
Room: Marquis Room

Speaker 4 of 6
Jan Karlseder, The Salk Institute for Biological Studies, USA
Telomere Driven Epigenetic Reprogramming during Cellular Aging

Monday, October 12 | 5:00PM - 7:15PM
DNA Damage Sensing and Signaling 2
Room: Marquis Room

Speaker 5 of 6
Zeenia Kaul, Children's Medical Research Institute, Australia
Short Talk: Five Dysfunctional Telomeres Precede Cellular Senescence in Normal Human Diploid Fibroblasts

Monday, October 12 | 5:00PM - 7:15PM
DNA Damage Sensing and Signaling 2
Room: Marquis Room

Speaker 6 of 6
Woodring E. Wright, University of Texas Southwestern Medical Center, USA
The Comparative Biology Of Replicative Senescence

Monday, October 12 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Monarch Room


Monday, October 12 | 7:30PM - 10:00PM
Poster Session 3
Room: Monarch Room


Tuesday, October 13 | 7:30AM - 8:30AM
Breakfast
Room: Kalinda Restaurant


Tuesday, October 13 | 8:30AM - 11:30AM
DNA Repair 2
Room: Marquis Room

Speaker 1 of 6
* Camilla Sjögren, Karolinska Institutet, Sweden

Tuesday, October 13 | 8:30AM - 11:30AM
DNA Repair 2
Room: Marquis Room

Speaker 2 of 6
Frederick W. Alt, Boston Children's Hospital, USA
DNA Double Strand Breaks, Translocations and B Cell Lymphoma

Tuesday, October 13 | 8:30AM - 11:30AM
DNA Repair 2
Room: Marquis Room

Speaker 3 of 6
David O. Ferguson, University of Michigan Medical School, USA
Multiple Roles of MRN in Double Strand Break Repair Pathways

Tuesday, October 13 | 8:30AM - 11:30AM
DNA Repair 2
Room: Marquis Room

Speaker 4 of 6
Marco F. Foiani, Instituto FIRC di Oncologia Molecolare, Italy
The DNA Damage Response during DNA Replication

Tuesday, October 13 | 8:30AM - 11:30AM
DNA Repair 2
Room: Marquis Room

Speaker 5 of 6
Huiling Xu, Peter MacCallum Cancer Centre, Australia
Short Talk: Cohesin-Mediated Modulation of Radiation-Induced DNA Damage Response

Tuesday, October 13 | 8:30AM - 11:30AM
DNA Repair 2
Room: Marquis Room

Speaker 6 of 6
Claudia Lukas, Novo Nordisk Foundation Center for Protein Research, Denmark
Short Talk: 53BP1 Nuclear Bodies: A Dynamic, Cell-Cycle-Regulated Surrogate of Replication, Proteotoxic, and Transcription-Coupled Genomic Stress

Tuesday, October 13 | 9:50AM - 10:10AM
Coffee Break
Room: Marquis Foyer


Tuesday, October 13 | 4:30PM - 5:00PM
Coffee Available
Room: Marquis Foyer


Tuesday, October 13 | 5:00PM - 7:00PM
Telomeres, DNA Repair and Human Disease
Room: Marquis Room

Speaker 1 of 5
* Steven E. Artandi, Stanford University, USA

Tuesday, October 13 | 5:00PM - 7:00PM
Telomeres, DNA Repair and Human Disease
Room: Marquis Room

Speaker 2 of 5
Monica Bessler, Children's Hospital of Philadelphia, USA
Dyskeratosis Congenita

Tuesday, October 13 | 5:00PM - 7:00PM
Telomeres, DNA Repair and Human Disease
Room: Marquis Room

Speaker 3 of 5
Katharina Schlacher, MD Anderson Cancer Center, USA
Short Talk: BRCA2 (FANCD1) Protects Stalled Replication Forks from Degradation, a Novel Pathway Shared with BRCA1 and Fanconi Anemia

Tuesday, October 13 | 5:00PM - 7:00PM
Telomeres, DNA Repair and Human Disease
Room: Marquis Room

Speaker 4 of 5
Peter J. McKinnon, St. Jude Children's Research Hospital, USA
Differential ATM Signaling from DNA Strand Breaks and Dysfunctional Telomeres

Tuesday, October 13 | 5:00PM - 7:00PM
Telomeres, DNA Repair and Human Disease
Room: Marquis Room

Speaker 5 of 5
Jerry W. Shay, University of Texas Southwestern Medical Center, USA
Will Telomerase Inhibitors Target Cancer Stem Cells?

Tuesday, October 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Monarch Room


Tuesday, October 13 | 8:00PM - 11:00PM
Entertainment
Room: Monarch Room


Tuesday, October 13 | 8:00PM - 11:00PM
Cash Bar
Room: Monarch Room


Wednesday, October 14 | 10:22AM - 10:22AM
Departure


*Session Chair
†Invited, not yet responded.