Web Desc
Overcoming the Crisis of TB and AIDS
Organizer(s): Anne E. Goldfeld and Stefan H.E. Kaufmann
Date: October 20 - 25, 2009
Location: Arusha International Conference Centre (meeting only), Arusha, United Rep of Tanzania
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
Tuberculosis (TB) is the largest cause of death in the AIDS setting, having caused approximately 50% of all AIDS deaths globally. Each infection on its own manipulates the host immune response to enhance the other infection’s pathogenicity, and the treatment of each involves long or lifelong therapy of complicated drug regimens. The focus of this Keystone Symposia meeting is to gain deeper insights into the immune pathology and deadly synergism between HIV and TB and its global toll in order to identify new ways to solve this global catastrophe by way of basic scientific discovery, and the development and delivery of vaccines, drugs and care. Mycobacterium tuberculosis survives in the vast majority of infected individuals without causing disease. However, as HIV compromises the immune system it fuels clinical emergence of TB and, as a result, has become the driving force for the current TB epidemics in Subsaharan Africa and Asia. TB in turn drives HIV-1 replication and causes HIV-1 disease progression. In order to effectively tackle this twin epidemic, integrated approaches encompassing basic immunological research, drug discovery, drug and vaccine design and delivery and novel approaches to delivering care in remote and impoverished areas must be integrated. This includes the following: virologic and bacteriologic research on the pathogens themselves; immunologic, molecular and cellular research on the host response; design, development and delivery of drugs and vaccines; development of different technologies for biomarkers of disease and cure; and novel drug and vaccine delivery systems. Moreover, basic discovery must be synergized with novel approaches to the delivery of TB and AIDS care in endemic areas. The overarching goal of the symposium is to gain a broad perspective on the problem of TB/AIDS – from its impact on life on earth to the basic biology of the organisms, the immune response – and to develop new paradigms of thinking and responses to deal with the humanitarian catastrophe of TB and AIDS co-infection.
Global Health Travel Award Deadline: May 19 2009
Scholarship Deadline: June 22 2009
Discounted Abstract Deadline: June 22 2009
Abstract Deadline: July 22 2009
Discounted Registration Deadline: August 20 2009
We gratefully acknowledge additional support for this conference from:
Bill & Melinda Gates Foundation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

AstraZeneca India Pvt Ltd
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI084377-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, October 20 | 3:00PM - 7:00PM
Registration
Room: Naura Springs Hotel Lobby


Wednesday, October 21 | 6:30AM - 8:00AM
Breakfast at Hotel
Room: Individual Hotels


Wednesday, October 21 | 8:30AM - 11:00AM
Registration
Room: AICC Karafu Lobby


Wednesday, October 21 | 10:00AM - 11:00AM
Coffee Available
Room: AICC Lower Lot


Wednesday, October 21 | 11:00AM - 1:00PM
The TB and AIDS Crisis: Why Are We Not Further Along? (Sess
ion with Grand Challenges in Global Health)

Room: AICC Simba Hall

Speaker 1 of 4
* Elias Zerhouni, Sanofi, France
Session Chair

Wednesday, October 21 | 11:00AM - 1:00PM
The TB and AIDS Crisis: Why Are We Not Further Along? (Sess
ion with Grand Challenges in Global Health)

Room: AICC Simba Hall

Speaker 2 of 4
Anne E. Goldfeld, Children's Hospital Boston, Harvard Medical School, USA
Welcome Remarks

Wednesday, October 21 | 11:00AM - 1:00PM
The TB and AIDS Crisis: Why Are We Not Further Along? (Sess
ion with Grand Challenges in Global Health)

Room: AICC Simba Hall

Speaker 3 of 4
David Baltimore, California Institute of Technology, USA
Engineering Immunity to Infectious Diseases

Wednesday, October 21 | 11:00AM - 1:00PM
The TB and AIDS Crisis: Why Are We Not Further Along? (Sess
ion with Grand Challenges in Global Health)

Room: AICC Simba Hall

Speaker 4 of 4
Tadataka Yamada, Mountain Field LLC, USA
The Role of Innovation

Wednesday, October 21 | 1:00PM - 2:30PM
Joint Lunch with Grand Challenges in Global Health
Room: AICC Lower Lot


Wednesday, October 21 | 2:30PM - 2:45PM
Keystone Symposia Welcoming Remarks & Orientation
Room: AICC Simba Hall


Wednesday, October 21 | 2:45PM - 5:00PM
Insights from Natural History of Disease
Room: AICC Simba Hall

Speaker 1 of 4
* Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany

Wednesday, October 21 | 2:45PM - 5:00PM
Insights from Natural History of Disease
Room: AICC Simba Hall

Speaker 2 of 4
Beatrice H. Hahn, University of Pennsylvania, USA
Natural SIV Infection of Wild-Living Chimpanzees is Associated with Increased Mortality and AIDS-Like Immunopathology

Wednesday, October 21 | 2:45PM - 5:00PM
Insights from Natural History of Disease
Room: AICC Simba Hall

Speaker 3 of 4
Paul D. van Helden, Stellenbosch University, South Africa
TB Genomics and TB/HIV in Africa

Wednesday, October 21 | 2:45PM - 5:00PM
Insights from Natural History of Disease
Room: AICC Simba Hall

Speaker 4 of 4
George M. Shaw, University of Pennsylvania, USA
Genetic Identity, Biological Phenotype and Evolutionary Pathways of Transmitted/Founder Viruses in Acute and Early HIV-1 and SIV Infection

Wednesday, October 21 | 5:30PM - 6:00PM
Poster Setup
Room: Naura Springs Ballroom


Wednesday, October 21 | 5:30PM - 7:00PM
Social Hour with Lite Bites
Room: Naura Springs Ballroom


Wednesday, October 21 | 6:30PM - 9:00PM
Poster Session 1
Room: Naura Springs Ballroom


Thursday, October 22 | 6:30AM - 8:00AM
Breakfast Included at Hotel
Room: Individual Hotels


Thursday, October 22 | 8:30AM - 12:00PM
TB, AIDS and Implications for Novel Interventions
Room: AICC Simba Hall

Speaker 1 of 7
* Judy Lieberman, Harvard University, USA

Thursday, October 22 | 8:30AM - 12:00PM
TB, AIDS and Implications for Novel Interventions
Room: AICC Simba Hall

Speaker 2 of 7
Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany
Immune Response to TB and Implications for Overcoming TB and AIDS

Thursday, October 22 | 8:30AM - 12:00PM
TB, AIDS and Implications for Novel Interventions
Room: AICC Simba Hall

Speaker 3 of 7
Anne E. Goldfeld, Children's Hospital Boston, Harvard Medical School, USA
The Immune Response to TB/HIV Co-Infection: Insights from the Natural History of Disease

Thursday, October 22 | 8:30AM - 12:00PM
TB, AIDS and Implications for Novel Interventions
Room: AICC Simba Hall

Speaker 4 of 7
David D. Ho, Aaron Diamond AIDS Research Center (ADARC), Columbia University Medical Center, USA
A Novel Approach to HIV-1 Prevention

Thursday, October 22 | 8:30AM - 12:00PM
TB, AIDS and Implications for Novel Interventions
Room: AICC Simba Hall

Speaker 5 of 7
Sébastien Gagneux, Swiss Tropical and Public Health Institute, Switzerland
Short Talk: Human T-Cell Epitopes of M. Tuberculosis are Evolutionarily Hyperconserved

Thursday, October 22 | 8:30AM - 12:00PM
TB, AIDS and Implications for Novel Interventions
Room: AICC Simba Hall

Speaker 6 of 7
Subash S. Babu, National Institutes of Health - ICER, India
Short Talk: Negative Regulation of Th17 Responses in Latent Tuberculosis by Regulatory T Cells

Thursday, October 22 | 8:30AM - 12:00PM
TB, AIDS and Implications for Novel Interventions
Room: AICC Simba Hall

Speaker 7 of 7
Christian G. Meyer, Bernhard Nocht Institute for Tropical Medicine, Germany
Short Talk: Human Genetic Factors in Tuberculosis: Candidate Genes and a Genome-Wide Association Study

Thursday, October 22 | 9:50AM - 10:20AM
Coffee Break
Room: AICC Upper Lawn


Thursday, October 22 | 12:00PM - 1:00PM
Lunch
Room: AICC Upper Lawn


Thursday, October 22 | 1:00PM - 2:45PM
TB, AIDS and Implications for Novel Interventions (continued
)

Room: AICC Simba Hall

Speaker 1 of 3
Abdallah S. Daar, University of Toronto, Canada
Building Capacity for Life Sciences Innovation and Health Product Development in Sub- Saharan Africa

Thursday, October 22 | 1:00PM - 2:45PM
TB, AIDS and Implications for Novel Interventions (continued
)

Room: AICC Simba Hall

Speaker 2 of 3
Robert J. Wilkinson, University of Cape Town, South Africa
Learning about Immunity to Tuberculosis from HIV Infected People

Thursday, October 22 | 1:00PM - 2:45PM
TB, AIDS and Implications for Novel Interventions (continued
)

Room: AICC Simba Hall

Speaker 3 of 3
Samuel Matoya Nyamweya, Medical Research Council, Gambia
Short Talk: A Study of Three Biomarkers of Immune Activation and Disease Progression: A Comparison between HIV-1 and HIV-2 Infections

Thursday, October 22 | 2:45PM - 3:15PM
Coffee Break
Room: AICC Upper Lawn


Thursday, October 22 | 3:15PM - 5:00PM
TB, AIDS and Implications for Novel Interventions (continued
)

Room: AICC Simba Hall

Speaker 1 of 5
* Paul D. van Helden, Stellenbosch University, South Africa

Thursday, October 22 | 3:15PM - 5:00PM
TB, AIDS and Implications for Novel Interventions (continued
)

Room: AICC Simba Hall

Speaker 2 of 5
Elizabeth L. Corbett, London School of Hygiene & Tropical Med / MLW Trust Clinical Research Programme, Malawi
Impact of Providing Periodic Access to Community-Level Diagnosis of Smear-Positive Disease on Community Control of Infectious Tuberculosis (DETECTB)

Thursday, October 22 | 3:15PM - 5:00PM
TB, AIDS and Implications for Novel Interventions (continued
)

Room: AICC Simba Hall

Speaker 3 of 5
Jeffery S. Cox, University of California, Berkeley, USA
Short Talk: Dual Regulatory Mechanisms Control ESX-1 Secretion in M. tuberculosis

Thursday, October 22 | 3:15PM - 5:00PM
TB, AIDS and Implications for Novel Interventions (continued
)

Room: AICC Simba Hall

Speaker 4 of 5
Anna Helena van't Hoog, Amsterdam Institute for Global Helath and Devleopment, Netherlands
Short Talk: Factors Associated with Prevalent Pulmonary Tuberculosis in Rural Western Kenya

Thursday, October 22 | 3:15PM - 5:00PM
TB, AIDS and Implications for Novel Interventions (continued
)

Room: AICC Simba Hall

Speaker 5 of 5
Bouke C. de Jong, Institute of Tropical Medicine, Antwerp, Belgium
Short Talk: Genome Sequence of M. africanum, a West African Cause of Human TB More Common in HIV Infected People

Thursday, October 22 | 5:30PM - 6:00PM
Poster Setup
Room: Naura Springs Ballroom


Thursday, October 22 | 5:30PM - 7:00PM
Social Hour with Lite Bites
Room: Naura Springs Ballroom


Thursday, October 22 | 6:30PM - 9:00PM
Poster Session 2
Room: Naura Springs Ballroom


Friday, October 23 | 6:30AM - 8:00AM
Breakfast Included at Hotel
Room: Individual Hotels


Friday, October 23 | 8:30AM - 12:00PM
Novel Drug Approaches to TB and AIDS
Room: AICC Simba Hall

Speaker 1 of 6
* Gail H. Cassell, Infectious Disease Research Institute, USA

Friday, October 23 | 8:30AM - 12:00PM
Novel Drug Approaches to TB and AIDS
Room: AICC Simba Hall

Speaker 2 of 6
Ronald S. Veazey, Tulane National Primate Research Center, USA
The Current State of Microbicides

Friday, October 23 | 8:30AM - 12:00PM
Novel Drug Approaches to TB and AIDS
Room: AICC Simba Hall

Speaker 3 of 6
Frank Kirchhoff, University of Ulm, Germany
Semen-Mediated Enhancement of HIV Infection

Friday, October 23 | 8:30AM - 12:00PM
Novel Drug Approaches to TB and AIDS
Room: AICC Simba Hall

Speaker 4 of 6
James C. Sacchettini, Texas A & M University, USA
Structure-Based Design of New TB Drugs

Friday, October 23 | 8:30AM - 12:00PM
Novel Drug Approaches to TB and AIDS
Room: AICC Simba Hall

Speaker 5 of 6
Wafaie W. Fawzi, Harvard School of Public Health, USA
Short Talk: The Role of Nutrition on Immune Response and Clinical Outcomes in TB and HIV Infection

Friday, October 23 | 8:30AM - 12:00PM
Novel Drug Approaches to TB and AIDS
Room: AICC Simba Hall

Speaker 6 of 6
Judy Lieberman, Harvard University, USA
Silencing Sexual Transmission of HSV-2 and HIV

Friday, October 23 | 9:50AM - 10:20AM
Coffee Break
Room: AICC Upper Lawn


Friday, October 23 | 12:00PM - 1:00PM
Lunch
Room: AICC Upper Lawn


Friday, October 23 | 1:00PM - 3:00PM
Delivery of Care: How Are We Going to Achieve Universal Acce
ss?

Room: AICC Simba Hall

Speaker 1 of 5
* Anne E. Goldfeld, Children's Hospital Boston, Harvard Medical School, USA

Friday, October 23 | 1:00PM - 3:00PM
Delivery of Care: How Are We Going to Achieve Universal Acce
ss?

Room: AICC Simba Hall

Speaker 2 of 5
Mario C. Raviglione, World Health Organization, Switzerland
Stop TB: The State of Treatment for XDR-, MDR- and Drug-Sensitive TB Thinking out of the Box to Treat TB and Interrupt New Infections on a Global Scale

Friday, October 23 | 1:00PM - 3:00PM
Delivery of Care: How Are We Going to Achieve Universal Acce
ss?

Room: AICC Simba Hall

Speaker 3 of 5
Yohannes Teshale, Gondar Medical School, Ethiopia
Short Talk: Doctor/Patient Perspective of MDR

Friday, October 23 | 1:00PM - 3:00PM
Delivery of Care: How Are We Going to Achieve Universal Acce
ss?

Room: AICC Simba Hall

Speaker 4 of 5
Yiming Shao, National Center for AIDS Prevention and Control, China
Evolution of AIDS Control Strategy and Scale Up of AIDS Care Program in China


Friday, October 23 | 1:00PM - 3:00PM
Delivery of Care: How Are We Going to Achieve Universal Acce
ss?

Room: AICC Simba Hall

Speaker 5 of 5
Gail H. Cassell, Infectious Disease Research Institute, USA
The MDR and XDR Catastrophe: How Are We Going to Overcome It?

Friday, October 23 | 3:00PM - 3:30PM
Coffee Break
Room: AICC Upper Lawn


Friday, October 23 | 3:30PM - 5:15PM
Delivery of Care: Thinking Outside the Box: Developing Need
Based Solutions

Room: AICC Simba Hall

Speaker 1 of 4
* Christian Lienhardt, World Health Organisation, Switzerland

Friday, October 23 | 3:30PM - 5:15PM
Delivery of Care: Thinking Outside the Box: Developing Need
Based Solutions

Room: AICC Simba Hall

Speaker 2 of 4
Anthony Moll, Church of Scotland Hospital, South Africa
Responding to MDR/XDR TB and AIDS in a Rural Resource Poor Environment

Friday, October 23 | 3:30PM - 5:15PM
Delivery of Care: Thinking Outside the Box: Developing Need
Based Solutions

Room: AICC Simba Hall

Speaker 3 of 4
Sok Thim, Cambodian Health Committee, Cambodia
Grassroots Solutions to Deliver and Scale up TB and AIDS Care

Friday, October 23 | 3:30PM - 5:15PM
Delivery of Care: Thinking Outside the Box: Developing Need
Based Solutions

Room: AICC Simba Hall

Speaker 4 of 4
Peter A. Singer, Grand Challenges Canada, Canada
From Lab to Village

Friday, October 23 | 5:30PM - 6:00PM
Poster Setup
Room: Naura Springs Ballroom


Friday, October 23 | 5:30PM - 7:00PM
Social Hour with Lite Bites
Room: Naura Springs Ballroom


Friday, October 23 | 6:30PM - 9:00PM
Poster Session 3
Room: Naura Springs Ballroom


Saturday, October 24 | 6:30AM - 8:00AM
Breakfast Included at Hotel
Room: Individual Hotels


Saturday, October 24 | 8:30AM - 10:30PM
Developing TB and AIDS Discovery Infrastructure
Room: AICC Simba Hall

Speaker 1 of 6
* Robert J. Wilkinson, University of Cape Town, South Africa

Saturday, October 24 | 8:30AM - 10:30PM
Developing TB and AIDS Discovery Infrastructure
Room: AICC Simba Hall

Speaker 2 of 6
Myron E. Essex, Harvard School of Public Health, USA
Establishing Scientific Infrastructure in an African Field Site: What has the Botswana AIDS Experience Taught us Going Forward

Saturday, October 24 | 8:30AM - 10:30PM
Developing TB and AIDS Discovery Infrastructure
Room: AICC Simba Hall

Speaker 3 of 6
Odile Ouwe Missi Oukem-Boyer, Chantal Biya International Reference Centre for Research on HIV/AIDS, Cameroon
Short Talk: The Central Africa Network on Tuberculosis, HIV/AIDS and Malaria (CANTAM) Project: Creation of a Network of Excellence to Improve Clinical Research in Central Africa

Saturday, October 24 | 8:30AM - 10:30PM
Developing TB and AIDS Discovery Infrastructure
Room: AICC Simba Hall

Speaker 4 of 6
Elopy N. Sibanda, University of Zimbabwe, Zimbabwe
Short Talk: Diagnosing HIV Infection and TB Drug Resistance in Africa, the Starting Point

Saturday, October 24 | 8:30AM - 10:30PM
Developing TB and AIDS Discovery Infrastructure
Room: AICC Simba Hall

Speaker 5 of 6
Edward A. Nardell, Brigham and Woman's Hospital, USA

Saturday, October 24 | 8:30AM - 10:30PM
Developing TB and AIDS Discovery Infrastructure
Room: AICC Simba Hall

Speaker 6 of 6
Shreemanta K. Parida, Sweden
Short Talk:

Saturday, October 24 | 10:30AM - 11:00AM
Coffee Break
Room: AICC Upper Lawn


Saturday, October 24 | 11:00AM - 12:35PM
Overcoming Major Challenges in TB and AIDS Drug and Vaccine
Development

Room: AICC Simba Hall

Speaker 1 of 4
* Myron E. Essex, Harvard School of Public Health, USA

Saturday, October 24 | 11:00AM - 12:35PM
Overcoming Major Challenges in TB and AIDS Drug and Vaccine
Development

Room: AICC Simba Hall

Speaker 2 of 4
Jerald C. Sadoff, Crucell Vaccine Institute, Janssen Pharmaceutical Companies of Johnson & Johnson, Netherlands
Aeras TB Vaccine Development

Saturday, October 24 | 11:00AM - 12:35PM
Overcoming Major Challenges in TB and AIDS Drug and Vaccine
Development

Room: AICC Simba Hall

Speaker 3 of 4
Helen McShane, Jenner Institute, UK
Short Talk: Results from Clinical Trials with a New TB Vaccine, MVA85A, in HIV-Infected People

Saturday, October 24 | 11:00AM - 12:35PM
Overcoming Major Challenges in TB and AIDS Drug and Vaccine
Development

Room: AICC Simba Hall

Speaker 4 of 4
David M. Lewinsohn, Oregon Health & Science University, USA
Short Talk: MR1-Dependent Presentation of Mycobacterium tuberculosis Antigens to Human CD8+ T Cells

Saturday, October 24 | 12:45PM - 1:45PM
Lunch
Room: AICC Upper Lawn


Saturday, October 24 | 1:45PM - 5:00PM
Overcoming Major Challenges in TB and AIDS Drug and Vaccine
Development

Room: AICC Simba Hall

Speaker 1 of 8
Brigitte Autran, Hôpital Pitié-Salpétrière, UPMC, France
Declined: Investigation of the Immune Response to AIDS and Novel Vaccine Design

Saturday, October 24 | 1:45PM - 5:00PM
Overcoming Major Challenges in TB and AIDS Drug and Vaccine
Development

Room: AICC Simba Hall

Speaker 2 of 8
Mark B. Feinberg, IAVI International AIDS Vaccine Initiative, USA
Declined: The Disappointing Results of the STEP Trial: How do They Advance our Understanding of the Challenges of HIV Vaccine Development and Inform the Next Steps Moving Forward?

Saturday, October 24 | 1:45PM - 5:00PM
Overcoming Major Challenges in TB and AIDS Drug and Vaccine
Development

Room: AICC Simba Hall

Speaker 3 of 8
* Roy Curtiss III, Arizona State University, USA

Saturday, October 24 | 1:45PM - 5:00PM
Overcoming Major Challenges in TB and AIDS Drug and Vaccine
Development

Room: AICC Simba Hall

Speaker 4 of 8
Phyllis J. Kanki, Harvard School of Public Health, USA
HIV Diversity in Africa: What We have Learned for Vaccine and Drug Development and Delivery

Saturday, October 24 | 1:45PM - 5:00PM
Overcoming Major Challenges in TB and AIDS Drug and Vaccine
Development

Room: AICC Simba Hall

Speaker 5 of 8
Jayne S. Sutherland, Medical Research Council, Gambia
Short Talk:

Saturday, October 24 | 1:45PM - 5:00PM
Overcoming Major Challenges in TB and AIDS Drug and Vaccine
Development

Room: AICC Simba Hall

Speaker 6 of 8
Tanjore S. Balganesh, Institute of Genomics and Integrative Biology - CSIR-IGIB, India
Discovery of Anti-Tuberculosis Agents: Building on a Decade of Learning!

Saturday, October 24 | 1:45PM - 5:00PM
Overcoming Major Challenges in TB and AIDS Drug and Vaccine
Development

Room: AICC Simba Hall

Speaker 7 of 8
* Alan Sher, NIAID, National Institutes of Health, USA
Immunologic Determinants of Mycobacterial Associated Immune Reconstitution Inflammatory Syndrome (IRIS) in a Murine Experimental Model

Saturday, October 24 | 1:45PM - 5:00PM
Overcoming Major Challenges in TB and AIDS Drug and Vaccine
Development

Room: AICC Simba Hall

Speaker 8 of 8
* Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany
Closing Remarks

Saturday, October 24 | 2:50PM - 3:20PM
Coffee Break
Room: AICC Upper Lawn


Saturday, October 24 | 5:30PM - 7:00PM
Social Hour with Lite Bites
Room: Naura Springs Ballroom


Saturday, October 24 | 6:00PM - 9:00PM
Entertainment
Room: Naura Springs Ballroom


Sunday, October 25 | 6:30AM - 8:30AM
Breakfast Included at Hotel
Room: Individual Hotels


Sunday, October 25 | 10:25AM - 10:25AM
Departure


*Session Chair.