Web Desc
Metabolism and Cancer Progression
joint with Cell Death Pathways: Apoptosis, Autophagy and Necrosis
Organizer(s): Eileen P. White, Craig B. Thompson and Chi Van Dang
Date: March 12 - 17, 2010
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Sponsored by Celgene Corporation
Summary of Meeting:
Otto Warburg initially drew attention to the distinct metabolic state of tumors compared to normal tissues over 75 years ago, where tumor cells commonly favor glycolysis over oxidative phosphorylation even in the presence of oxygen (Warburg effect or aerobic glycolysis). Insight into the role and mechanism of this metabolic switch in tumorigenesis, and the utility of and means to therapeutically exploit altered metabolism in cancer was not clear, other than for utilization for FDG-PET imaging. Recently the metabolic requirements of tumor cells and the links to common pathway alterations in human cancers have been gradually emerging. It is now apparent that metabolic demand in tumor cells is high due to deregulation of cell growth, and that this constitutive activation of growth signaling pathways can disconnect cellular metabolism from nutrient and growth factor availability. Subversion of cellular metabolism for biosynthetic purposes is required to sustain deregulated tumor cell growth but can also restrict energy production that can limit tumor cell adaptation to metabolic stress. Hypoxic and acidic conditions in the tumor microenvironment are byproducts of these events and are common features of the tumor microenvironment that can activate stress responses, influence tumor growth, and impair treatment. Many of the oncogenic pathways altered in tumor cells modulate cell metabolism while enabling growth in these adverse conditions. Adaptation of tumor cells to stress through activation of the catabolic pathway of autophagy and its role in damage mitigation and promoting tumor cell survival to metabolic stress is also now emerging. The vision for this meeting is to bring together leaders in the fields of cancer, signaling and metabolism to discuss emerging discoveries and their application to improving cancer therapy.
Scholarship Deadline: November 12 2009
Discounted Abstract Deadline: November 12 2009
Abstract Deadline: December 10 2009
Discounted Registration Deadline: January 12 2010
We gratefully acknowledge additional support for this conference from:
Celgene CorporationCell Signaling Technology, Inc.Seahorse Bioscience, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Pfizer Biopharmaceuticals
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA144429-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, March 12 | 3:00PM - 7:30PM
Registration
Room: BC Foyer


Friday, March 12 | 6:30PM - 7:30PM
Refreshments
Room: BC Foyer


Friday, March 12 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: British/Columbia Ballroom

Speaker 1 of 3
* Eileen P. White, Rutgers Cancer Institute of New Jersey, USA

Friday, March 12 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: British/Columbia Ballroom

Speaker 2 of 3
Joan S. Brugge, Harvard Medical School, USA
Diversity of Cell Death Pathways in Organogenesis and Oncogenesis

Friday, March 12 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: British/Columbia Ballroom

Speaker 3 of 3
Lewis C. Cantley, Weill Cornell Medicine, USA
PI 3-Kinase and Cancer Cell Metabolism

Saturday, March 13 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Saturday, March 13 | 8:00AM - 11:15AM
Metabolism Regulation in Model Organisms
Room: Columbia Ballroom

Speaker 1 of 7
* Joan S. Brugge, Harvard Medical School, USA

Saturday, March 13 | 8:00AM - 11:15AM
Metabolism Regulation in Model Organisms
Room: Columbia Ballroom

Speaker 2 of 7
Steven L. McKnight, University of Texas Southwestern Medical Center, USA
Lessons from Metabolic Regulation in Yeast

Saturday, March 13 | 8:00AM - 11:15AM
Metabolism Regulation in Model Organisms
Room: Columbia Ballroom

Speaker 3 of 7
Nika N. Danial, Dana-Farber Cancer Institute, USA
Energy Metabolism in Genetically Defined Subtypes of Diffuse Large B Cell Lymphoma

Saturday, March 13 | 8:00AM - 11:15AM
Metabolism Regulation in Model Organisms
Room: Columbia Ballroom

Speaker 4 of 7
Yue Xiong, University of North Carolina at Chapel Hill, USA
Acetylation Regulation of Metabolism

Saturday, March 13 | 8:00AM - 11:15AM
Metabolism Regulation in Model Organisms
Room: Columbia Ballroom

Speaker 5 of 7
Chi Van Dang, University of Pennsylvania, USA
Regulation of Cancer Metabolism by Myc

Saturday, March 13 | 8:00AM - 11:15AM
Metabolism Regulation in Model Organisms
Room: Columbia Ballroom

Speaker 6 of 7
Jing Chen, Winship Cancer Institute, Emory University, USA
Short Talk: Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

Saturday, March 13 | 8:00AM - 11:15AM
Metabolism Regulation in Model Organisms
Room: Columbia Ballroom

Speaker 7 of 7
William C. Comb, University of North Carolina, Chapel Hill, USA
Short Talk: IKK-Dependent Phosphorylation and Feedback Inhibition of PI3K Promotes Nutrient Deprivation-Induced Autophagy

Saturday, March 13 | 8:00AM - 11:15AM
Apoptosis Pathways
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 1 of 7
* Anthony G. Letai, Dana-Farber Cancer Institute, USA


Saturday, March 13 | 8:00AM - 11:15AM
Apoptosis Pathways
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 2 of 7
Suzanne Cory-Adams, Walter & Eliza Hall Institute of Medical Research, Australia
The Bcl-2 Family in Cancer Development and Cancer Treatment


Saturday, March 13 | 8:00AM - 11:15AM
Apoptosis Pathways
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 3 of 7
Loren D. Walensky, Dana-Farber Cancer Institute, USA
Dissecting the Activation Pathway of Pro-Apoptotic BAX: Mechanistic Insights and Pharmacologic Opportunities


Saturday, March 13 | 8:00AM - 11:15AM
Apoptosis Pathways
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 4 of 7
Xin Niu, McMaster University, Canada
Short Talk: Identification and Mechanistic Characterization of Novel Bax Inihibitors


Saturday, March 13 | 8:00AM - 11:15AM
Apoptosis Pathways
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 5 of 7
Vishva M. Dixit, Genentech, Inc., USA
Identification of a Stabilizing Deubiquitinase for Mcl-1 that is Over-Expressed in Tumors


Saturday, March 13 | 8:00AM - 11:15AM
Apoptosis Pathways
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 6 of 7
David W. Andrews, Sunnybrook Research Institute, Canada
Mechanisms of Mitochondrial Membrane Permeabilization by Pro-Apoptotic Bcl-2 Family Proteins


Saturday, March 13 | 8:00AM - 11:15AM
Apoptosis Pathways
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 7 of 7
Ingrid E. Wertz, Genentech, Inc., USA
Short Talk: Resistance to Anti-tubulin Chemotherapeutics is Regulated by Mcl–1 and FBW7


Saturday, March 13 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Saturday, March 13 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Saturday, March 13 | 11:15AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Saturday, March 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Saturday, March 13 | 2:30PM - 4:30PM
Workshop 1: PI3 Kinase Regulation and Cancer
Room: Columbia Ballroom

Speaker 1 of 9
* Lewis C. Cantley, Weill Cornell Medicine, USA

Saturday, March 13 | 2:30PM - 4:30PM
Workshop 1: PI3 Kinase Regulation and Cancer
Room: Columbia Ballroom

Speaker 2 of 9
Brian Grabiner, Biogen, USA
Identification and Clinical Assessment of Genes that Regulate the Response of Cancers to Rapamycin through Pooled RNAi Screens

Saturday, March 13 | 2:30PM - 4:30PM
Workshop 1: PI3 Kinase Regulation and Cancer
Room: Columbia Ballroom

Speaker 3 of 9
Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Alternative Metabolic Strategies for Growth in Glioblastoma: Glucose vs. Glutamine for Support of Cell Proliferation and Tumorigenesis

Saturday, March 13 | 2:30PM - 4:30PM
Workshop 1: PI3 Kinase Regulation and Cancer
Room: Columbia Ballroom

Speaker 4 of 9
Barry Bochner, Biolog, Inc., USA
Metabolic Analysis of Isogenic Cells with Altered Cancer-Related Genes

Saturday, March 13 | 2:30PM - 4:30PM
Workshop 1: PI3 Kinase Regulation and Cancer
Room: Columbia Ballroom

Speaker 5 of 9
Jonathan L. Coloff, University of Illinois at Chicago, USA
A Metabolic Checkpoint Controls Puma Transcription and Protein Stability For Survival of Activated and Leukemic T Cells

Saturday, March 13 | 2:30PM - 4:30PM
Workshop 1: PI3 Kinase Regulation and Cancer
Room: Columbia Ballroom

Speaker 6 of 9
Kurt Fisher, Transplant Center at the Nebraska Medical Center, USA
The Molecular Scaffold, Kinase Suppressor of Ras 1 (KSR1), Potentiates H-RasV12 Induced Transformation and Expands Cellular Capacity for Glycolysis and Oxidative Phosphorylation

Saturday, March 13 | 2:30PM - 4:30PM
Workshop 1: PI3 Kinase Regulation and Cancer
Room: Columbia Ballroom

Speaker 7 of 9
Ching-yi Chang, Duke University Medical Center, USA
The Metabolic Regulator ERRalpha, a Downstream Target of HER2/IGF1, as a Therapeutic Target in Breast Cancer

Saturday, March 13 | 2:30PM - 4:30PM
Workshop 1: PI3 Kinase Regulation and Cancer
Room: Columbia Ballroom

Speaker 8 of 9
Christina H. Eng, Pfizer, USA
Ammonia Derived from Glutaminolysis is a Diffusible Regulator of Autophagy

Saturday, March 13 | 2:30PM - 4:30PM
Workshop 1: PI3 Kinase Regulation and Cancer
Room: Columbia Ballroom

Speaker 9 of 9
James M. Phang, NCI at Frederick, National Institutes of Health, USA
MiR-23b* Regulates Proline Oxidase, a Mitochondrial Metabolic Tumor Suppressor, in Renal Cancer

Saturday, March 13 | 2:30PM - 4:30PM
Workshop 1: Methods for the Detection of Non-Apoptotic Cell
Death
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 1 of 7
* Douglas R. Green, St. Jude Children's Research Hospital, USA


Saturday, March 13 | 2:30PM - 4:30PM
Workshop 1: Methods for the Detection of Non-Apoptotic Cell
Death
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 2 of 7
Vassiliki Karantza, Cancer Institute of New Jersey, USA
Autophagy Regulates keratin 8 Homeostasis in Mammary Epithelial Cells and in Breast Tumors


Saturday, March 13 | 2:30PM - 4:30PM
Workshop 1: Methods for the Detection of Non-Apoptotic Cell
Death
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 3 of 7
Brandon White, San Jose State University, USA
Flavonoids Kill Breast Cancer Cells While Inhibiting Caspase Activity: Is this Apoptosis?


Saturday, March 13 | 2:30PM - 4:30PM
Workshop 1: Methods for the Detection of Non-Apoptotic Cell
Death
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 4 of 7
Anna Katharina Simon, University of Oxford, UK
Detection of Autophagic Flux in Clinical Samples


Saturday, March 13 | 2:30PM - 4:30PM
Workshop 1: Methods for the Detection of Non-Apoptotic Cell
Death
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 5 of 7
Suzanne Hibbs, Sigma-Aldrich Research Biotech, USA
An Application of Zinc Finger Nuclease Technology to Create Knockout Cancer Lines


Saturday, March 13 | 2:30PM - 4:30PM
Workshop 1: Methods for the Detection of Non-Apoptotic Cell
Death
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 6 of 7
Jayanta Debnath, University of California, San Francisco, USA
ATG12 Conjugation to ATG3 Restricts The Expansion of Mitochondrial Mass and Promotes Cell Death


Saturday, March 13 | 2:30PM - 4:30PM
Workshop 1: Methods for the Detection of Non-Apoptotic Cell
Death
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 7 of 7
Haymanti Bhanot, University of Toledo, College of Medicine, USA
Mechanisms Underlying Methuosis in Human Glioblastoma Cells


Saturday, March 13 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Saturday, March 13 | 5:00PM - 7:00PM
Metabolic Differences between Normal and Cancer Cells
Room: Columbia Ballroom

Speaker 1 of 5
* David M. Sabatini, Whitehead Institute for Biomedical Research, USA

Saturday, March 13 | 5:00PM - 7:00PM
Metabolic Differences between Normal and Cancer Cells
Room: Columbia Ballroom

Speaker 2 of 5
Eyal Gottlieb, Technion - Israel Institute of Technology, Israel
The Roles of Prolyl Hydroxylases in Metabolism and Cancer

Saturday, March 13 | 5:00PM - 7:00PM
Metabolic Differences between Normal and Cancer Cells
Room: Columbia Ballroom

Speaker 3 of 5
Valeria Fantin, ORIC Pharmaceuticals, USA
Metabolic Signaling in Cancer

Saturday, March 13 | 5:00PM - 7:00PM
Metabolic Differences between Normal and Cancer Cells
Room: Columbia Ballroom

Speaker 4 of 5
Sybille Mazurek, Universität Gießen, ScheBo Biotech AG, Germany
Pyruvate Kinase M2 and Cancer

Saturday, March 13 | 5:00PM - 7:00PM
Metabolic Differences between Normal and Cancer Cells
Room: Columbia Ballroom

Speaker 5 of 5
Claudio Santos, London Research Institute, UK
Short Talk: Identification of Metabolic Enzymes Essential for Survival of Prostate Cancer Cells by Functional Studies

Saturday, March 13 | 5:00PM - 7:00PM
Non-Apoptotic Pathways in Model Organisms
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 1 of 5
* Daniel J. Klionsky, University of Michigan, USA


Saturday, March 13 | 5:00PM - 7:00PM
Non-Apoptotic Pathways in Model Organisms
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 2 of 5
Frank Madeo, University of Graz, Austria
Programmed Cell Death in Yeast: Subroutines, Mechanisms and Purposes


Saturday, March 13 | 5:00PM - 7:00PM
Non-Apoptotic Pathways in Model Organisms
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 3 of 5
Vladimir I. Titorenko, Concordia University, Canada
Short Talk: Novel Anti-Aging Compounds Greatly Extend Yeast Life Span by Targeting a Programmed Necrotic Cell Death Pathway Triggered by the Age-Related Buildup of Free Fatty Acids


Saturday, March 13 | 5:00PM - 7:00PM
Non-Apoptotic Pathways in Model Organisms
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 4 of 5
Thomas P. Neufeld, University of Minnesota, USA
Autophagic Pathways in Drosophila: Good or Evil?


Saturday, March 13 | 5:00PM - 7:00PM
Non-Apoptotic Pathways in Model Organisms
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 5 of 5
John M. Abrams, University of Texas Southwestern Medical Center, USA
Cell Death Regulatory Networks in Drosophila


Saturday, March 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Saturday, March 13 | 7:30PM - 10:00PM
Poster Session 1
Room: Pacific Ballroom


Sunday, March 14 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Sunday, March 14 | 8:00AM - 11:00AM
Metabolic Adaptation in Cancer (Joint)
Room: British/Columbia Ballroom

Speaker 1 of 6
* Marja Jäättelä, Danish Cancer Society Research Center, Denmark

Sunday, March 14 | 8:00AM - 11:00AM
Metabolic Adaptation in Cancer (Joint)
Room: British/Columbia Ballroom

Speaker 2 of 6
Eileen P. White, Rutgers Cancer Institute of New Jersey, USA
Role of Autophagy in Cancer and Therapy

Sunday, March 14 | 8:00AM - 11:00AM
Metabolic Adaptation in Cancer (Joint)
Room: British/Columbia Ballroom

Speaker 3 of 6
Guido Kroemer, Cordeliers Research Center, France
Autophagy in Stress Adaptation, Avoidance of Cell Death and Longevity

Sunday, March 14 | 8:00AM - 11:00AM
Metabolic Adaptation in Cancer (Joint)
Room: British/Columbia Ballroom

Speaker 4 of 6
Karen H. Vousden, Francis Crick Institute, UK
Control of Metabolism by p53

Sunday, March 14 | 8:00AM - 11:00AM
Metabolic Adaptation in Cancer (Joint)
Room: British/Columbia Ballroom

Speaker 5 of 6
Rob Cairns, University Health Network, Canada
Short Talk: Cancer-Associated Metabolite 2-Hydroxyglutarate Accumulates in AML with IDH1/2 Mutations

Sunday, March 14 | 8:00AM - 11:00AM
Metabolic Adaptation in Cancer (Joint)
Room: British/Columbia Ballroom

Speaker 6 of 6
Josh Lyon Andersen, Brigham Young University, USA
Short Talk: Metabolic Regulation of Caspase-2

Sunday, March 14 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Sunday, March 14 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Sunday, March 14 | 11:15AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Sunday, March 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Sunday, March 14 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Sunday, March 14 | 5:00PM - 7:00PM
Therapeutic Modulation of Metabolism
Room: Columbia Ballroom

Speaker 1 of 5
* Robert T. Abraham, Vividion Therapeutics, USA

Sunday, March 14 | 5:00PM - 7:00PM
Therapeutic Modulation of Metabolism
Room: Columbia Ballroom

Speaker 2 of 5
Peter F. Carmeliet, University of Leuven, VIB, Belgium
Oxygen, Metabolism and Angiogenesis

Sunday, March 14 | 5:00PM - 7:00PM
Therapeutic Modulation of Metabolism
Room: Columbia Ballroom

Speaker 3 of 5
John L. Cleveland, The Scripps Research Institute, USA
Therapeutic Modulation of Autophagy in Cancer

Sunday, March 14 | 5:00PM - 7:00PM
Therapeutic Modulation of Metabolism
Room: Columbia Ballroom

Speaker 4 of 5
Uwe Haberkorn, University Hospital Heidelberg, Germany
Imaging Metabolism in Cancer

Sunday, March 14 | 5:00PM - 7:00PM
Therapeutic Modulation of Metabolism
Room: Columbia Ballroom

Speaker 5 of 5
Paul C. McDonald, British Columbia Cancer Research Center, Canada
Short Talk: Therapeutic Targeting of Carbonic Anhydrase IX Results in Inhibition of Growth and Metastasis of Breast Tumors

Sunday, March 14 | 5:00PM - 7:00PM
Autophagic Pathways
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 1 of 5
* Noboru Mizushima, University of Tokyo, Japan


Sunday, March 14 | 5:00PM - 7:00PM
Autophagic Pathways
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 2 of 5
Daniel J. Klionsky, University of Michigan, USA
The Regulation of Macroautophagy


Sunday, March 14 | 5:00PM - 7:00PM
Autophagic Pathways
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 3 of 5
Francesco Cecconi, University of Rome Tor Vergata, Italy
Short Talk: Ambra1 Regulates Autophagosome Formation and Plays a Role in Controlling Cell Proliferation


Sunday, March 14 | 5:00PM - 7:00PM
Autophagic Pathways
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 4 of 5
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Chaperone-Mediated Autophagy in Organismal Aging


Sunday, March 14 | 5:00PM - 7:00PM
Autophagic Pathways
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 5 of 5
Vojo Deretic, University of New Mexico Health Sciences Center, USA
Autophagy in Immunity: Microbes, Mitochondria and Cell Survival vs Cell Death


Sunday, March 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Sunday, March 14 | 7:30PM - 10:00PM
Poster Session 2
Room: Pacific Ballroom


Monday, March 15 | 7:00AM - 11:00AM
Poster Setup
Room: Pacific Ballroom


Monday, March 15 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Monday, March 15 | 8:00AM - 11:15AM
Survival and Death in Development and Disease (Joint)
Room: British/Columbia Ballroom

Speaker 1 of 7
* Karen H. Vousden, Francis Crick Institute, UK

Monday, March 15 | 8:00AM - 11:15AM
Survival and Death in Development and Disease (Joint)
Room: British/Columbia Ballroom

Speaker 2 of 7
Noboru Mizushima, University of Tokyo, Japan
Lessons from Autophagy Deficient Mouse Models

Monday, March 15 | 8:00AM - 11:15AM
Survival and Death in Development and Disease (Joint)
Room: British/Columbia Ballroom

Speaker 3 of 7
Marja Jäättelä, Danish Cancer Society Research Center, Denmark
Lysosomal Sphingolipid Metabolism as a Target for Cancer Therapy

Monday, March 15 | 8:00AM - 11:15AM
Survival and Death in Development and Disease (Joint)
Room: British/Columbia Ballroom

Speaker 4 of 7
Douglas R. Green, St. Jude Children's Research Hospital, USA
The Mitochondrion: The Weapon Employed in Apoptopic Suicide

Monday, March 15 | 8:00AM - 11:15AM
Survival and Death in Development and Disease (Joint)
Room: British/Columbia Ballroom

Speaker 5 of 7
Gerard I. Evan, University of Cambridge, UK
Inhibiting Oncogenes for Cancer Therapy

Monday, March 15 | 8:00AM - 11:15AM
Survival and Death in Development and Disease (Joint)
Room: British/Columbia Ballroom

Speaker 6 of 7
Joan Boren, Cambridge Research Institute, CRUK, UK
Short Talk: Changes in Cell Lipid Content during Induction of Apoptosis

Monday, March 15 | 8:00AM - 11:15AM
Survival and Death in Development and Disease (Joint)
Room: British/Columbia Ballroom

Speaker 7 of 7
Rebecca Lock, University of California, San Francisco, USA
Short Talk: Autophagy Inhibition Alters Glucose Metabolism and Promotes Epithelial Differentiation During Ras-Mediated Oncogenic Transformation

Monday, March 15 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Monday, March 15 | 11:30AM - 12:30PM
Lunch
Room: Pacific Ballroom


Monday, March 15 | 12:30PM - 2:30PM
Poster Session 3
Room: Pacific Ballroom


Monday, March 15 | 2:30PM - 4:30PM
Workshop 2: Metabolic Assessment and Regulation
Room: Columbia Ballroom

Speaker 1 of 9
* Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA

Monday, March 15 | 2:30PM - 4:30PM
Workshop 2: Metabolic Assessment and Regulation
Room: Columbia Ballroom

Speaker 2 of 9
Michelle F. Clasquin, Pfizer, Inc., USA
High-Resolution Full-Scan Mass Spectrometry for Discovery and Characterization of Unknown Metabolites

Monday, March 15 | 2:30PM - 4:30PM
Workshop 2: Metabolic Assessment and Regulation
Room: Columbia Ballroom

Speaker 3 of 9
Andrew N. Lane, University of Louisville, USA
Translational Metabolomics in Human Lung Cancer

Monday, March 15 | 2:30PM - 4:30PM
Workshop 2: Metabolic Assessment and Regulation
Room: Columbia Ballroom

Speaker 4 of 9
Kenjiro Kami, Human Metabolome Technologies, Inc., Japan
CE-MS-based Metabolomics Identified a Novel Anaerobic Energy Metabolism of Cancer Cells

Monday, March 15 | 2:30PM - 4:30PM
Workshop 2: Metabolic Assessment and Regulation
Room: Columbia Ballroom

Speaker 5 of 9
Fionnuala M. Morrish, Fred Hutchinson Cancer Research Center, USA
The Metabolism of Tumor Progression and Regression in the pInsMycERTam/Bcl-xL Mouse Model of Pancreatic Beta Cell Neoplasia

Monday, March 15 | 2:30PM - 4:30PM
Workshop 2: Metabolic Assessment and Regulation
Room: Columbia Ballroom

Speaker 6 of 9
Min Wu, Massachusetts General Hospital and Broad Institute, USA
Metabolic Dependency on Fatty Acid Oxidation of Glioblastoma SF188

Monday, March 15 | 2:30PM - 4:30PM
Workshop 2: Metabolic Assessment and Regulation
Room: Columbia Ballroom

Speaker 7 of 9
Ameeta Kelekar, University of Minnesota, USA
Post-Translational Regulation of Human Noxa; its Role in Glucose Deprivation Induced Death

Monday, March 15 | 2:30PM - 4:30PM
Workshop 2: Metabolic Assessment and Regulation
Room: Columbia Ballroom

Speaker 8 of 9
Kathryn E. Wellen, University of Pennsylvania, USA
The Hexosamine Biosynthetic Pathway Links Glutamine Metabolism and Signaling to Regulate Cell Growth

Monday, March 15 | 2:30PM - 4:30PM
Workshop 2: Metabolic Assessment and Regulation
Room: Columbia Ballroom

Speaker 9 of 9
Linda Z. Penn, Princess Margaret Cancer Centre, Canada
Connecting the Dots between Tumor Cell Metabolism and the Mevalonate Pathway

Monday, March 15 | 2:30PM - 4:30PM
Workshop 2: Pathological Implications of Non-Apoptotic Cell
Death
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 1 of 7
* Junying Yuan, Harvard Medical School, USA


Monday, March 15 | 2:30PM - 4:30PM
Workshop 2: Pathological Implications of Non-Apoptotic Cell
Death
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 2 of 7
Nelson Cesar Di Paolo, Emory University, USA
Necrosis and Autophagy, but not Apoptosis, are Induced in Macrophages in vivo upon Interaction with Adenovirus


Monday, March 15 | 2:30PM - 4:30PM
Workshop 2: Pathological Implications of Non-Apoptotic Cell
Death
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 3 of 7
Sam McNeal, Rhode Island Hospital, USA
Divergent Roles of RIP1 in Septic Liver Injury


Monday, March 15 | 2:30PM - 4:30PM
Workshop 2: Pathological Implications of Non-Apoptotic Cell
Death
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 4 of 7
Cristina Muñoz-Pinedo, Institut d'Investigacio Biomedica de Bellvitge, Spain
Glucose Deprivation Induces an Atypical Form of Apoptosis Mediated by Caspase-8 in Bax, Bak Deficient Cells


Monday, March 15 | 2:30PM - 4:30PM
Workshop 2: Pathological Implications of Non-Apoptotic Cell
Death
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 5 of 7
Andrey A. Parkhitko, Brigham and Women's Hospital Harvard Medical School, USA
Role of Autophagy in the Pathogenesis of Tuberous Sclerosis Complex


Monday, March 15 | 2:30PM - 4:30PM
Workshop 2: Pathological Implications of Non-Apoptotic Cell
Death
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 6 of 7
Poonam Sansanwal, Stanford University, USA
Mitochondrial Autophagy: A Novel Mechanism for Cellular Injury in Nephropathic Cystinosis


Monday, March 15 | 2:30PM - 4:30PM
Workshop 2: Pathological Implications of Non-Apoptotic Cell
Death
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 7 of 7
Andrew M. Leidal, University of California, San Francisco, USA
Autophagy Contributes to KSHV v-cyclin-induced Senescence


Monday, March 15 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Monday, March 15 | 5:00PM - 7:00PM
Cancer and Predisposition Genes
Room: Columbia Ballroom

Speaker 1 of 5
* William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA

Monday, March 15 | 5:00PM - 7:00PM
Cancer and Predisposition Genes
Room: Columbia Ballroom

Speaker 2 of 5
Cheryl L. Walker, Baylor College of Medicine, USA
Participation of TSC2 in a Cytoplasmic ATM Signaling Pathway that Regulates mTORC1 in Response to ROS

Monday, March 15 | 5:00PM - 7:00PM
Cancer and Predisposition Genes
Room: Columbia Ballroom

Speaker 3 of 5
Kwok-Kin Wong, Dana-Farber Cancer Institute, USA
Integrative Genomic and Proteomic Analyses Identify Novel Targets for Lkb1 Deficient Metastatic Lung Tumors


Monday, March 15 | 5:00PM - 7:00PM
Cancer and Predisposition Genes
Room: Columbia Ballroom

Speaker 4 of 5
Jason A. Chesney, University of Louisville, USA
Coupling Glycolysis With Cell Cycle Progression

Monday, March 15 | 5:00PM - 7:00PM
Cancer and Predisposition Genes
Room: Columbia Ballroom

Speaker 5 of 5
Sang-Min Jeon, Ajou University, South Korea
Short Talk: The LKB1-AMPK Pathway is Essential for Cell Survival during Glucose Starvation through Redox Regulation

Monday, March 15 | 5:00PM - 7:00PM
Cell Death Induction for Cancer Therapy
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 1 of 5
* John A. Hickman, Agon, France


Monday, March 15 | 5:00PM - 7:00PM
Cell Death Induction for Cancer Therapy
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 2 of 5
Anthony G. Letai, Dana-Farber Cancer Institute, USA
Why Chemotherapy Works – Chemosensitive Cancer Cells are more Primed for Apoptosis


Monday, March 15 | 5:00PM - 7:00PM
Cell Death Induction for Cancer Therapy
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 3 of 5
Jerry M. Adams, Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: Puma-Mediated Leukocyte Apoptosis is Critical for gamma-Irradiation-Induced Thymic Lymphoma Development


Monday, March 15 | 5:00PM - 7:00PM
Cell Death Induction for Cancer Therapy
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 4 of 5
Saul H. Rosenberg, Abbott Laboratories, USA
Bcl-2 Family Inhibitors for the Treatment of Cancer


Monday, March 15 | 5:00PM - 7:00PM
Cell Death Induction for Cancer Therapy
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 5 of 5
Leigh Zawel, Cullinan Oncology, USA
Therapeutic Targeting of Inhibitor of Apoptosis Proteins


Monday, March 15 | 7:00PM - 7:00PM
On Own for Dinner


Tuesday, March 16 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Tuesday, March 16 | 8:00AM - 11:15AM
mTOR and Nutrient Sensing
Room: Columbia Ballroom

Speaker 1 of 7
* Gerard I. Evan, University of Cambridge, UK

Tuesday, March 16 | 8:00AM - 11:15AM
mTOR and Nutrient Sensing
Room: Columbia Ballroom

Speaker 2 of 7
David M. Sabatini, Whitehead Institute for Biomedical Research, USA
mTOR and the Control of Growth

Tuesday, March 16 | 8:00AM - 11:15AM
mTOR and Nutrient Sensing
Room: Columbia Ballroom

Speaker 3 of 7
Reuben J. Shaw, The Salk Institute for Biological Studies, USA
The LKB1/ AMPK Pathway Controls Metabolism and Cell Growth

Tuesday, March 16 | 8:00AM - 11:15AM
mTOR and Nutrient Sensing
Room: Columbia Ballroom

Speaker 4 of 7
Michael N. Hall, University of Basel, Switzerland
TOR Signaling and the Control of Cell and Animal Growth

Tuesday, March 16 | 8:00AM - 11:15AM
mTOR and Nutrient Sensing
Room: Columbia Ballroom

Speaker 5 of 7
Robert T. Abraham, Vividion Therapeutics, USA
Interplay between Glutamine Metabolism and mTOR Signaling during Autophagy

Tuesday, March 16 | 8:00AM - 11:15AM
mTOR and Nutrient Sensing
Room: Columbia Ballroom

Speaker 6 of 7
Bin Zheng, Harvard Medical School, USA
Short Talk: Cross-Talk between the LKB1-AMPK and BRAF-MEK-ERK Signaling Pathways

Tuesday, March 16 | 8:00AM - 11:15AM
mTOR and Nutrient Sensing
Room: Columbia Ballroom

Speaker 7 of 7
Matthew J. Martin, AstraZeneca, UK
Short Talk: AMP-Activated Protein Kinase in Melanoma: Biology and Therapeutic Opportunities

Tuesday, March 16 | 8:00AM - 11:15AM
Non-Conventional Cell Death Pathways
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 1 of 7
* Frank Madeo, University of Graz, Austria


Tuesday, March 16 | 8:00AM - 11:15AM
Non-Conventional Cell Death Pathways
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 2 of 7
Junying Yuan, Harvard Medical School, USA
Mechanisms of Programmed Cell Death: From Apoptosis to Necroptosis


Tuesday, March 16 | 8:00AM - 11:15AM
Non-Conventional Cell Death Pathways
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 3 of 7
Michael B. Yaffe, Massachusetts Institute of Technology, USA
Mitotic Catastrophe: Mechanisms and Therapeutic Induction for Cancer Treatment


Tuesday, March 16 | 8:00AM - 11:15AM
Non-Conventional Cell Death Pathways
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 4 of 7
Paul R. Clarke, University of Dundee, UK
Short Talk: Controlling Apoptosis in Mitosis and during Mitotic Arrest


Tuesday, March 16 | 8:00AM - 11:15AM
Non-Conventional Cell Death Pathways
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 5 of 7
Peter Vandenabeele, VIB, Ghent University, Belgium
TNF-Induced Necrosis, Multiple Regulation of RIP1 Kinase Activity


Tuesday, March 16 | 8:00AM - 11:15AM
Non-Conventional Cell Death Pathways
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 6 of 7
Oliver Florey, Babraham Institute, UK
Short Talk: A Case for Murder: Entosis is a Cell Killing Mechanism Requiring Autophagy Proteins


Tuesday, March 16 | 8:00AM - 11:15AM
Non-Conventional Cell Death Pathways
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 7 of 7
Dale E. Bredesen, Buck Institute for Research on Aging, USA
Role of Cell Death Signaling in Alzheimer's Disease


Tuesday, March 16 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Tuesday, March 16 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, March 16 | 3:30PM - 4:30PM
Special Lecture (Joint)
Room: British/Columbia Ballroom

Speaker 1 of 1
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Therapeutic Exploitation of Metabolic Differences between Normal and Cancer Cells

Tuesday, March 16 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Tuesday, March 16 | 5:00PM - 7:00PM
Hypoxia and Metabolic Stress
Room: Columbia Ballroom

Speaker 1 of 5
* Peter F. Carmeliet, University of Leuven, VIB, Belgium

Tuesday, March 16 | 5:00PM - 7:00PM
Hypoxia and Metabolic Stress
Room: Columbia Ballroom

Speaker 2 of 5
Pierre Sonveaux, University of Louvain, Belgium
Short Talk: Targeting Lactate-Fueled Respiration Selectively Kills Hypoxic Tumor Cells

Tuesday, March 16 | 5:00PM - 7:00PM
Hypoxia and Metabolic Stress
Room: Columbia Ballroom

Speaker 3 of 5
Adrian L. Harris, University of Oxford, Weatherall Institute of Molecular Medicine, UK
Role of Carbonic Anhydrase 9 in Regulation of Tumour pH and Response to Antiangiogenic Therapy

Tuesday, March 16 | 5:00PM - 7:00PM
Hypoxia and Metabolic Stress
Room: Columbia Ballroom

Speaker 4 of 5
Sally A. Kornbluth, Duke University Medical Center, USA
Metabolic Control of Caspases

Tuesday, March 16 | 5:00PM - 7:00PM
Hypoxia and Metabolic Stress
Room: Columbia Ballroom

Speaker 5 of 5
William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
Dioxygenases as Therapeutic Targets in Cancer

Tuesday, March 16 | 5:00PM - 7:00PM
Immunologic Cell Death
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 1 of 5
* Guido Kroemer, Cordeliers Research Center, France


Tuesday, March 16 | 5:00PM - 7:00PM
Immunologic Cell Death
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 2 of 5
Polly Matzinger, NIAID, National Institutes of Health, USA
Conversations between Tissues and T Cells


Tuesday, March 16 | 5:00PM - 7:00PM
Immunologic Cell Death
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 3 of 5
Matthew L. Albert, Genentech, Inc., USA
The Immunogenicity of Distinct Cell Death Modalities


Tuesday, March 16 | 5:00PM - 7:00PM
Immunologic Cell Death
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 4 of 5
Seung Hyun Han, Seoul National University, South Korea
Short Talk: Functional and Phenotypic Changes in Dendritic Cells Loaded with Irradiation-Induced Apoptotic Cancer Cells


Tuesday, March 16 | 5:00PM - 7:00PM
Immunologic Cell Death
This session is from Cell Death Pathways
Room: British Ballroom

Speaker 5 of 5
Michel Gilliet, University Hospital of Lausanne, Switzerland
Breaking Innate Immune Tolerance to Self-Nucleic Acids Released by Dying Cells


Tuesday, March 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Tuesday, March 16 | 8:00PM - 11:00PM
Entertainment
Room: Pacific Ballroom


Tuesday, March 16 | 8:00PM - 11:00PM
Cash Bar
Room: Pacific Ballroom


Wednesday, March 17 | 10:25AM - 10:25AM
Departure


*Session Chair.