Web Desc
Nuclear Receptors: Signaling, Gene Regulation and Cancer
joint with Nuclear Receptors: Development, Physiology and Disease
Organizer(s): W. Lee Kraus, Myles Brown and Karen Elizabeth Knudsen
Date: March 21 - 26, 2010
Location: Keystone Resort, Keystone, CO, USA
Supported by The Directors' Fund
Summary of Meeting:
Nuclear receptors (NRs) comprise a large family of ligand-regulated transcription factors that play critical roles in physiology and disease. Much of the focus has been on the nuclear actions of NRs, including interactions with coregulators, modulation of chromatin structure, and regulation of gene expression. Recent studies, however, have also suggested a role for membrane- or cytoplasmic-initiated actions of NRs and crosstalk with other cellular signaling pathways. Current studies are aimed at understanding how the ligand-dependent molecular actions of NRs, including their subcellular localization, binding across the genome, and interaction with the proteome, connect to their roles in physiological and pathophysiological processes, including hormone-regulated cancers. In addition, NRs are being explored as targets for drug development, with many compounds on the market or in ongoing clinical trials. This meeting will highlight recent breakthroughs in NR research, promote interactions between scientists from industry and academia, and provide opportunities for senior scientists to interact with younger researchers and trainees.
Scholarship Deadline: November 23 2009
Discounted Abstract Deadline: November 23 2009
Abstract Deadline: December 28 2009
Discounted Registration Deadline: January 22 2010
We gratefully acknowledge additional support for this conference from:
Cayman Chemical Company, Inc.GTx, Inc.Integrated DNA Technologies
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Educational donation provided by Amgen


Geoffrey Greene
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13DK084688-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 21 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Sunday, March 21 | 6:30PM - 7:30PM
Refreshments
Room: Longs Peak Foyer


Sunday, March 21 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: Grays/Longs Peaks

Speaker 1 of 1
Gideon Dreyfuss, HHMI/University of Pennsylvania School of Medicine, USA
RNA-Protein Complexes (RNPs): The Instruments of Post-Transcriptional Gene Regulation

Monday, March 22 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Monday, March 22 | 8:00AM - 11:00AM
Signaling and Physiology
Room: Grays Peak

Speaker 1 of 7
* Kathryn B. Horwitz, University of Colorado Health Sciences Center, USA

Monday, March 22 | 8:00AM - 11:00AM
Signaling and Physiology
Room: Grays Peak

Speaker 2 of 7
Carole R. Mendelson, University of Texas Southwestern Medical Center, USA
Mechanisms in Progesterone Receptor Regulation of Inflammatory Signaling in Pregnancy and Labor

Monday, March 22 | 8:00AM - 11:00AM
Signaling and Physiology
Room: Grays Peak

Speaker 3 of 7
Sheue-Yann Cheng, NCI, National Institutes of Health, USA
Novel Signaling of Mutant Thyroid Hormone Receptors in Carcinogenesis

Monday, March 22 | 8:00AM - 11:00AM
Signaling and Physiology
Room: Grays Peak

Speaker 4 of 7
John A. Cidlowski, NIEHS, National Institutes of Health, USA
Talk Title to be Determined

Monday, March 22 | 8:00AM - 11:00AM
Signaling and Physiology
Room: Grays Peak

Speaker 5 of 7
Iris Z. Jaffe, Tufts-New England Medical Center, USA
Mineralocorticoid Receptor Regulation of Vascular Gene Expression: Role in Vascular Function and Disease

Monday, March 22 | 8:00AM - 11:00AM
Signaling and Physiology
Room: Grays Peak

Speaker 6 of 7
Jennifer K. Richer, University of Colorado Anschutz Medical Campus, USA
Short Talk: MicroRNAs Differentially Expressed in Luminal versus Triple Negative Breast Cancer Control Estrogen Receptor alpha and Growth Factor Receptor Expression and Aspects of Tumor Metabolism

Monday, March 22 | 8:00AM - 11:00AM
Signaling and Physiology
Room: Grays Peak

Speaker 7 of 7
Mark G. Obukowicz, Pfizer Inc., USA
Short Talk: Dissociated Agonist of the Glucocorticoid Receptor (DAGR): 60 Years in the Making (and of Waiting)

Monday, March 22 | 8:00AM - 11:15AM
Nuclear Receptors in Development and Disease
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 1 of 7
* Carl S. Thummel, University of Utah School of Medicine, USA


Monday, March 22 | 8:00AM - 11:15AM
Nuclear Receptors in Development and Disease
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 2 of 7
Peter Tontonoz, University of California, Los Angeles, USA
Liver X Receptors in Metabolism, Inflammation and Disease


Monday, March 22 | 8:00AM - 11:15AM
Nuclear Receptors in Development and Disease
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 3 of 7
Carlie J. M. de Vries, University of Amsterdam, Netherlands
NR4A Orphan Nuclear Receptors in Vascular Disease


Monday, March 22 | 8:00AM - 11:15AM
Nuclear Receptors in Development and Disease
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 4 of 7
Joe Thornton, University of Chicago, USA
Evolution of Nuclear Receptors


Monday, March 22 | 8:00AM - 11:15AM
Nuclear Receptors in Development and Disease
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 5 of 7
Henry M. Krause, University of Toronto, Canada
Coordination of Developmental Check Points and Metabolism


Monday, March 22 | 8:00AM - 11:15AM
Nuclear Receptors in Development and Disease
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 6 of 7
Jason M. Tennessen, Indiana University, USA
Short Talk: The Drosophila Estrogen-Related Receptor Coordinates Carbohydrate Metabolism with Cell Growth


Monday, March 22 | 8:00AM - 11:15AM
Nuclear Receptors in Development and Disease
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 7 of 7
Marc R. Van Gilst, Fred Hutchinson Cancer Research Center, USA
Short Talk: From the Nematode Nuclear Receptor Milieu, C. elegans NHR-49 Emerges as a Casanova


Monday, March 22 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, March 22 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Monday, March 22 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Monday, March 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Monday, March 22 | 2:30PM - 4:30PM
Workshop 1: Hot Topics: Physiology
Room: Grays Peak

Speaker 1 of 6
* Carolyn L. Smith, Baylor College of Medicine, USA

Monday, March 22 | 2:30PM - 4:30PM
Workshop 1: Hot Topics: Physiology
Room: Grays Peak

Speaker 2 of 6
Michihisa Umetani, University of Houston, USA
LXRbeta Promotes Vascular Reendothelialization via a Novel Mechanism Involving non-Nuclear Signaling in Endothelium

Monday, March 22 | 2:30PM - 4:30PM
Workshop 1: Hot Topics: Physiology
Room: Grays Peak

Speaker 3 of 6
Terry D. Hinds, University of Toledo, USA
Discovery of Glucocorticoid Receptor beta in Mice and its Role in Insulin Signaling and Metabolism

Monday, March 22 | 2:30PM - 4:30PM
Workshop 1: Hot Topics: Physiology
Room: Grays Peak

Speaker 4 of 6
Ronni Nielsen, University of Southern Denmark, Denmark

Monday, March 22 | 2:30PM - 4:30PM
Workshop 1: Hot Topics: Physiology
Room: Grays Peak

Speaker 5 of 6
Brian Sandri, University of Minnesota, USA
Evidence for a Global Role of the Estrogen- Regulated ZEB1 Transcription Factor in Modulating Adiposity through Regulation of FGF-21

Monday, March 22 | 2:30PM - 4:30PM
Workshop 1: Hot Topics: Physiology
Room: Grays Peak

Speaker 6 of 6
Jens Tiefenbach, University of Toronto, Canada
A live Zebrafish-based Screening System for Human Nuclear Receptors Allows for Tissue Selective Drug Discovery

Monday, March 22 | 2:30PM - 4:30PM
Workshop 1: Hot Topics: Nuclear Receptors in Development and
Disease
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 1 of 5
Lilach Gilboa, Weizmann Institute of Science, Israel
Hormonal Coordination of Niche Formation and Germ Line Stem Cell Establishment


Monday, March 22 | 2:30PM - 4:30PM
Workshop 1: Hot Topics: Nuclear Receptors in Development and
Disease
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 2 of 5
Chris R. Gissendanner, University of Louisiana at Monroe, USA
The C. elegans NR4A Nuclear Receptor: Conserved Functions in Cell Proliferation and Cell Differentiation during Organ Morphogenesis


Monday, March 22 | 2:30PM - 4:30PM
Workshop 1: Hot Topics: Nuclear Receptors in Development and
Disease
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 3 of 5
Wen Xie, University of Pittsburgh, USA
Unexpected Hepatotoxicity and Inflammatory Gene Activation in FXR Transgenic Mice


Monday, March 22 | 2:30PM - 4:30PM
Workshop 1: Hot Topics: Nuclear Receptors in Development and
Disease
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 4 of 5
Wendong Huang, Beckman Research Institute of City of Hope, USA
FXR, Liver Repair and Aging


Monday, March 22 | 2:30PM - 4:30PM
Workshop 1: Hot Topics: Nuclear Receptors in Development and
Disease
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 5 of 5
* Li Wang, University of Connecticut, USA
Nuclear Receptor SHP-dependent Mitochondrial Targeting in Apoptosis Signaling and Tumor Growth


Monday, March 22 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, March 22 | 5:00PM - 7:00PM
Mechanisms of Nuclear Receptor Signaling (Joint)
Room: Grays/Longs Peaks

Speaker 1 of 5
* Donald P. McDonnell, Duke University School of Medicine, USA

Monday, March 22 | 5:00PM - 7:00PM
Mechanisms of Nuclear Receptor Signaling (Joint)
Room: Grays/Longs Peaks

Speaker 2 of 5
Christopher K. Glass, University of California, San Diego, USA
Lineage-Determining Transcription Factors Prime Cis-regulatory Elements Required for Ligand-dependent Gene Expression

Monday, March 22 | 5:00PM - 7:00PM
Mechanisms of Nuclear Receptor Signaling (Joint)
Room: Grays/Longs Peaks

Speaker 3 of 5
Keith R. Yamamoto, University of California, San Francisco, USA
Cell and Gene Selectivity of Glucocorticoid Action: DNA Sequences as Specific GR Ligands

Monday, March 22 | 5:00PM - 7:00PM
Mechanisms of Nuclear Receptor Signaling (Joint)
Room: Grays/Longs Peaks

Speaker 4 of 5
Gordon L. Hager, NCI, National Institutes of Health, USA
Global Regulation of Chromatin Structure and Gene Expression by Glucocorticoid Receptors

Monday, March 22 | 5:00PM - 7:00PM
Mechanisms of Nuclear Receptor Signaling (Joint)
Room: Grays/Longs Peaks

Speaker 5 of 5
Jason S. Carroll, Cancer Research UK, University of Cambridge, UK
Short Talk: FoxA1 is the Critical Determinant of ER Binding and Activity in Breast Cancer Cells

Monday, March 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Monday, March 22 | 7:30PM - 10:00PM
Poster Session 1
Room: Shavano/Torreys


Tuesday, March 23 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Tuesday, March 23 | 8:00AM - 11:15AM
Ligands, Cofactors, and Gene Regulation
Room: Grays Peak

Speaker 1 of 7
* Kenneth S. Korach, NIEHS, National Institutes of Health, USA

Tuesday, March 23 | 8:00AM - 11:15AM
Ligands, Cofactors, and Gene Regulation
Room: Grays Peak

Speaker 2 of 7
Donald P. McDonnell, Duke University School of Medicine, USA
The ERRalpha/PGC-1 Complex Links HER2/IGF1 Initiated Signaling Events to the Expression of Target Genes that Impact Breast Cancer Pathogenesis

Tuesday, March 23 | 8:00AM - 11:15AM
Ligands, Cofactors, and Gene Regulation
Room: Grays Peak

Speaker 3 of 7
Michael G. Rosenfeld, University of California, San Diego, USA
Epigenetics: Life, Death, and Tumor Translocations

Tuesday, March 23 | 8:00AM - 11:15AM
Ligands, Cofactors, and Gene Regulation
Room: Grays Peak

Speaker 4 of 7
Carol A. Lange, University of Minnesota, USA
Mechanisms of PR Coupling to MAP Kinases

Tuesday, March 23 | 8:00AM - 11:15AM
Ligands, Cofactors, and Gene Regulation
Room: Grays Peak

Speaker 5 of 7
Geoffrey L. Greene, University of Chicago, USA
Structural Basis of ER Ligand Selectivity

Tuesday, March 23 | 8:00AM - 11:15AM
Ligands, Cofactors, and Gene Regulation
Room: Grays Peak

Speaker 6 of 7
Kendall W. Nettles, The Scripps Research Institute, USA
Short Talk: Coupling of Estrogen Receptor Conformation and Ligand Orientation Determine Graded Signaling Activity

Tuesday, March 23 | 8:00AM - 11:15AM
Ligands, Cofactors, and Gene Regulation
Room: Grays Peak

Speaker 7 of 7
Wei Xu, University of Wisconsin-Madison, USA
Short Talk: “Yin-Yang” Principle for Estrogen Receptor Heterodimers in Breast Cancer: A Targeted Molecular Approach for Therapeutic Development

Tuesday, March 23 | 8:00AM - 11:15AM
Metabolic Control and Circadian Rhythms
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 1 of 7
* Susanne Mandrup, University of Southern Denmark, Denmark


Tuesday, March 23 | 8:00AM - 11:15AM
Metabolic Control and Circadian Rhythms
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 2 of 7
Urs Albrecht, University of Fribourg, Switzerland
The Clock Component Per2 Coordinates Circadian Output by Interaction with Nuclear Receptors


Tuesday, March 23 | 8:00AM - 11:15AM
Metabolic Control and Circadian Rhythms
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 3 of 7
Ueli Schibler, University of Geneva, Switzerland
The Regulation of Circadian Gene Expression in Peripheral Cell Types


Tuesday, March 23 | 8:00AM - 11:15AM
Metabolic Control and Circadian Rhythms
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 4 of 7
David D. Moore, Baylor College of Medicine, USA
Gut Feelings


Tuesday, March 23 | 8:00AM - 11:15AM
Metabolic Control and Circadian Rhythms
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 5 of 7
Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland
Integrating Metabolic Control by NAD+ Sensors


Tuesday, March 23 | 8:00AM - 11:15AM
Metabolic Control and Circadian Rhythms
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 6 of 7
Pavlos Pissios, NGM Bio, USA
Short Talk: Regulation of Glucose and Lipid Metabolism by Nicotinamide N-Methyltransferase


Tuesday, March 23 | 8:00AM - 11:15AM
Metabolic Control and Circadian Rhythms
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 7 of 7
Thomas P. Burris, Washington University School of Medicine, USA
Short Talk: Characterization of Synthetic REV-ERB ligands


Tuesday, March 23 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, March 23 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, March 23 | 11:15AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Tuesday, March 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Tuesday, March 23 | 2:30PM - 4:30PM
Workshop 2: Hot Topics: Gene Regulation
Room: Grays Peak

Speaker 1 of 7
* Steven K. Nordeen, University of Colorado Health Sciences Center, USA

Tuesday, March 23 | 2:30PM - 4:30PM
Workshop 2: Hot Topics: Gene Regulation
Room: Grays Peak

Speaker 2 of 7
Katherine Anne Burns, University of Cincinnati College of Medicine, USA
Selective Mutations in the D-domain of Mouse ERalpha Alters Nuclear Translocation and ERalpha’s Non-ERE Gene Regulatory Mechanism

Tuesday, March 23 | 2:30PM - 4:30PM
Workshop 2: Hot Topics: Gene Regulation
Room: Grays Peak

Speaker 3 of 7
Nasun Hah, The Salk Institute for Biological Studies, USA
Exploring the Direct Estrogen-Regulated Transcriptome in Breast Cancer Cells Using GRO-Seq

Tuesday, March 23 | 2:30PM - 4:30PM
Workshop 2: Hot Topics: Gene Regulation
Room: Grays Peak

Speaker 4 of 7
Moray J. Campbell, Roswell Park Cancer Institute, USA
VDR Regulation of Histone Modifications and miRNA Combine to Fine-Tune Transcriptional Cycling of Target Genes

Tuesday, March 23 | 2:30PM - 4:30PM
Workshop 2: Hot Topics: Gene Regulation
Room: Grays Peak

Speaker 5 of 7
Robert H. Oakley, NIEHS, National Institutes of Health, USA
Crosstalk between Glucocorticoid and G Protein-Coupled Receptor Signaling Pathways Mediated by Arrestins

Tuesday, March 23 | 2:30PM - 4:30PM
Workshop 2: Hot Topics: Gene Regulation
Room: Grays Peak

Speaker 6 of 7
Joshua D. Stender, University of California, San Diego, USA
Control of Pro-Inflammatory Gene Programs by Active Histone Methylation and Demethylation

Tuesday, March 23 | 2:30PM - 4:30PM
Workshop 2: Hot Topics: Gene Regulation
Room: Grays Peak

Speaker 7 of 7
Daniel G. Gioeli, University of Virginia, USA
CDK9 Regulates AR Activity and Cell Growth through Serine 81 Phosphorylation

Tuesday, March 23 | 2:30PM - 4:30PM
Workshop 2: Hot Topics: Co-Regulators and Post-Transcription
al Control
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 1 of 6
Inna I. Astapova, Beth Israel Deaconess Medical Center, USA
The Nuclear Corepressor, NCoR, Controls the Set Point of the Thyroid Axis In vivo


Tuesday, March 23 | 2:30PM - 4:30PM
Workshop 2: Hot Topics: Co-Regulators and Post-Transcription
al Control
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 2 of 6
Karine C. Gauthier, Université de Lyon, France
The Thyroid Hormone Receptor TRalpha Protects Against Atherosclerosis Development


Tuesday, March 23 | 2:30PM - 4:30PM
Workshop 2: Hot Topics: Co-Regulators and Post-Transcription
al Control
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 3 of 6
Atul Chopra, Case Western Reserve University, USA
Hepatic SRC-2 Regulates Energy Balance by Coordinating Bile Secretion and Dietary Fat Absorption


Tuesday, March 23 | 2:30PM - 4:30PM
Workshop 2: Hot Topics: Co-Regulators and Post-Transcription
al Control
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 4 of 6
Nan Wu, University of Pennsylvania, USA
Arf-bp1 and Pam are Novel Regulators of Circadian Rhythm that Target Rev-erbalpha for Degradation


Tuesday, March 23 | 2:30PM - 4:30PM
Workshop 2: Hot Topics: Co-Regulators and Post-Transcription
al Control
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 5 of 6
William Bourguet, Centre de Biochimie Structurale, France
A Unique Secondary Structure Switch Controls Constitutive Gene Silencing by Retinoic Acid Receptor


Tuesday, March 23 | 2:30PM - 4:30PM
Workshop 2: Hot Topics: Co-Regulators and Post-Transcription
al Control
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 6 of 6
* Patrick R. Griffin, The Scripps Research Institute, USA
HDX of Intact VDR/RXR Heterodimer Reveals Agonist and DNA-Induced Conformational Changes Important for Coactivator Interaction


Tuesday, March 23 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, March 23 | 5:00PM - 7:00PM
Physiology and Metabolism (Joint)
Room: Grays/Longs Peaks

Speaker 1 of 5
* David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA

Tuesday, March 23 | 5:00PM - 7:00PM
Physiology and Metabolism (Joint)
Room: Grays/Longs Peaks

Speaker 2 of 5
Bruce M. Spiegelman, Harvard Medical School, USA
Transcriptional Regulation of Adipogenesis and Energy Homeostasis

Tuesday, March 23 | 5:00PM - 7:00PM
Physiology and Metabolism (Joint)
Room: Grays/Longs Peaks

Speaker 3 of 5
Deborah Clegg, Cedars-Sinai Medical Center, USA
Estrogen, Adipose Tissue, and The Metabolic Syndrome

Tuesday, March 23 | 5:00PM - 7:00PM
Physiology and Metabolism (Joint)
Room: Grays/Longs Peaks

Speaker 4 of 5
Ronald M. Evans, HHMI/The Salk Institute, USA
PPARs in Metabolism and Disease

Tuesday, March 23 | 5:00PM - 7:00PM
Physiology and Metabolism (Joint)
Room: Grays/Longs Peaks

Speaker 5 of 5
Austin J. Cooney, Baylor College of Medicine, USA
Short Talk: Regulation of ES Cells and iPS by Nuclear Receptors

Tuesday, March 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Tuesday, March 23 | 7:30PM - 10:00PM
Poster Session 2
Room: Shavano/Torreys


Wednesday, March 24 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Wednesday, March 24 | 8:00AM - 11:15AM
Chromatin and Transcription
Room: Grays Peak

Speaker 1 of 7
* Dean P. Edwards, Baylor College of Medicine, USA

Wednesday, March 24 | 8:00AM - 11:15AM
Chromatin and Transcription
Room: Grays Peak

Speaker 2 of 7
Roland Schüle, Universitaetsklinikum Freiburg, Germany
Androgen Receptor Function is Regulated by Histone Demethylases: Implication for Prostate Cancer

Wednesday, March 24 | 8:00AM - 11:15AM
Chromatin and Transcription
Room: Grays Peak

Speaker 3 of 7
W. Lee Kraus, University of Texas Southwestern Medical Center, USA
Genomic Analyses of Estrogen-Regulated Transcription Reveal New Facets of the Estrogen Signaling Pathway

Wednesday, March 24 | 8:00AM - 11:15AM
Chromatin and Transcription
Room: Grays Peak

Speaker 4 of 7
Raphael Metivier, Université de Rennes I, France
Estrogen Receptor Transcriptional Activity: A Dynamic Integration of Multi-Leveled Information

Wednesday, March 24 | 8:00AM - 11:15AM
Chromatin and Transcription
Room: Grays Peak

Speaker 5 of 7
Shigeaki Kato, University of Tokyo, Japan
Epigenetic Regulators Supporting Nuclear Receptor Function

Wednesday, March 24 | 8:00AM - 11:15AM
Chromatin and Transcription
Room: Grays Peak

Speaker 6 of 7
Inez Rogatsky, Weill Medical College of Cornell University, USA
Short Talk: The Role of GRIP1 in Type I Interferon Signaling and Glucocorticoid-Induced Immunosuppression

Wednesday, March 24 | 8:00AM - 11:15AM
Chromatin and Transcription
Room: Grays Peak

Speaker 7 of 7
Catharine L. Smith, University of Arizona, USA
Short Talk: Histone Deacetylases Function as Glucocorticoid Receptor Coactivators

Wednesday, March 24 | 8:00AM - 11:15AM
Cell Fate and Tissue Homeostasis
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 1 of 7
* Joyce J. Repa, University of Texas Southwestern Medical Center, USA


Wednesday, March 24 | 8:00AM - 11:15AM
Cell Fate and Tissue Homeostasis
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 2 of 7
Thomas Perlmann, Karolinska Institutet, Ludwig Institute for Cancer Research, Sweden
NR4A Orphan Nuclear Receptors Trigger a Neuroprotective Pathway Induced by Elevated Cyclic AMP


Wednesday, March 24 | 8:00AM - 11:15AM
Cell Fate and Tissue Homeostasis
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 3 of 7
Gary D. Hammer, University of Michigan, USA
SF-1/DAX: Adrenocortical Stem/Progenitor Cell Fate and Multipotency


Wednesday, March 24 | 8:00AM - 11:15AM
Cell Fate and Tissue Homeostasis
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 4 of 7
Frances M. Sladek, University of California, Riverside, USA
HNF4alpha Function and Regulation -- New Insights into an Old Receptor


Wednesday, March 24 | 8:00AM - 11:15AM
Cell Fate and Tissue Homeostasis
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 5 of 7
Erin G. Schuetz, St. Jude Children's Research Hospital, USA
Cis and Trans Genetic Variation Affecting Hepatic Nuclear Hormone Receptor Expression


Wednesday, March 24 | 8:00AM - 11:15AM
Cell Fate and Tissue Homeostasis
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 6 of 7
Jae W. Lee, Oregon Health and Science University, USA
Short Talk: Histone H3-lysine 4 Methyltransferases Specialized for Nuclear Receptor-Mediated Metabolic Homeostasis


Wednesday, March 24 | 8:00AM - 11:15AM
Cell Fate and Tissue Homeostasis
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 7 of 7
Kai Ge, NIDDK, National Institutes of Health, USA
Short Talk: Epigenetic Regulation of PPARgamma and Adipogenesis


Wednesday, March 24 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, March 24 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, March 24 | 11:15AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Wednesday, March 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Wednesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Hot Topics: Signaling and Cancer
Room: Grays Peak

Speaker 1 of 7
* † Jonna Frasor, University of Illinois, Chicago, USA

Wednesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Hot Topics: Signaling and Cancer
Room: Grays Peak

Speaker 2 of 7
Shannon T. Bailey, WuXi NextCODE, USA
Loss of ER-Regulated microRNAs is Fundamental to Hormone-Independent Breast Cancer Cells

Wednesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Hot Topics: Signaling and Cancer
Room: Grays Peak

Speaker 3 of 7
Ruby Dhar, University of Chicago, USA
Genome Wide RNAi Screen to Identify Novel Targets for Estrogen Signaling in Breast Cancer

Wednesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Hot Topics: Signaling and Cancer
Room: Grays Peak

Speaker 4 of 7
Zeynep Madak-Erdogan, University of Illinois at Urbana-Champaign, USA
Critical Role of ERK2 in Estrogen Receptor alpha (ERalpha)-mediated Regulation of Gene Expression and Proliferation of Breast Cancer Cells

Wednesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Hot Topics: Signaling and Cancer
Room: Grays Peak

Speaker 5 of 7
Lillian J. Eichner, The Salk Institute, USA
miR-378 Induces Metabolic Shift in Breast Cancer Cells via the ERRgamma Transcriptional Pathway

Wednesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Hot Topics: Signaling and Cancer
Room: Grays Peak

Speaker 6 of 7
Jun Qin, Baylor College of Medicine, USA
COUP-TFII Regulates Angiogenesis to Promote Tumor Growth and Metastasis

Wednesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Hot Topics: Signaling and Cancer
Room: Grays Peak

Speaker 7 of 7
Matthew J. Schiewer, Thomas Jefferson University, USA
Impact of PARP1 on AR Signaling and Therapeutic Response in Prostate Cancer

Wednesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Hot Topics: Nuclear Receptors in Metabolism
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 1 of 6
* Carolyn L. Cummins, University of Toronto, Canada


Wednesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Hot Topics: Nuclear Receptors in Metabolism
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 2 of 6
Kari T. Chambers, Washington University School of Medicine, USA
PGC-1beta Regulates Hepatic Energy Metabolism Under ad Libitum Fed Conditions


Wednesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Hot Topics: Nuclear Receptors in Metabolism
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 3 of 6
Philipp M. Kulozik, German Cancer Research Center, Germany
Lack of Hepatic TBL1/TBLR1 Transcriptional Co-Activator Function Promotes Obesity-Related Dyslipidemia


Wednesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Hot Topics: Nuclear Receptors in Metabolism
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 4 of 6
Hong Soon Kang, NIEHS, National Institutes of Health, USA
Retinoid-Related Orphan Receptor alpha (RORalpha) Positively Regulates Obesity, Hepatic Steatosis, and Inflammation


Wednesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Hot Topics: Nuclear Receptors in Metabolism
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 5 of 6
Yanqiao Zhang, Northeastern Ohio Universities College of Medicine, USA
Identification of Novel Pathways that Control FXR-mediated Hypocholesterolemia


Wednesday, March 24 | 2:30PM - 4:30PM
Workshop 3: Hot Topics: Nuclear Receptors in Metabolism
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 6 of 6
Katja A. Lamia, The Scripps Research Institute, USA
AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation


Wednesday, March 24 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, March 24 | 5:00PM - 7:15PM
Coregulators and Gene Expression (Joint)
Room: Grays/Longs Peaks

Speaker 1 of 6
* Carole R. Mendelson, University of Texas Southwestern Medical Center, USA

Wednesday, March 24 | 5:00PM - 7:15PM
Coregulators and Gene Expression (Joint)
Room: Grays/Longs Peaks

Speaker 2 of 6
Bert W. O'Malley, Baylor College of Medicine, USA
NR Coactivators: Physiology and Disease

Wednesday, March 24 | 5:00PM - 7:15PM
Coregulators and Gene Expression (Joint)
Room: Grays/Longs Peaks

Speaker 3 of 6
Catherine C. Thompson, Pfizer, USA
LXR is a Therapeutic Target for Skin Aging and Dermal Inflammatory Indications

Wednesday, March 24 | 5:00PM - 7:15PM
Coregulators and Gene Expression (Joint)
Room: Grays/Longs Peaks

Speaker 4 of 6
Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Epigenetic Regulation of Nuclear Receptor Expression, Cistromes, and Function

Wednesday, March 24 | 5:00PM - 7:15PM
Coregulators and Gene Expression (Joint)
Room: Grays/Longs Peaks

Speaker 5 of 6
Ralf Kittler, University of Texas Southwestern Medical Center, USA
Short Talk: A cis-Regulatory Map for Nuclear Receptors in Breast Cancer

Wednesday, March 24 | 5:00PM - 7:15PM
Coregulators and Gene Expression (Joint)
Room: Grays/Longs Peaks

Speaker 6 of 6
Ronald N. Margolis, NIDDK, National Institutes of Health, USA
Short Talk: dkCOIN: A BIG Solution to Data Integration

Wednesday, March 24 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Wednesday, March 24 | 7:30PM - 10:00PM
Poster Session 3
Room: Shavano/Torreys


Thursday, March 25 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Thursday, March 25 | 8:00AM - 11:15AM
Steroid Receptors, Signaling and Cancer
Room: Grays Peak

Speaker 1 of 7
* John A. Cidlowski, NIEHS, National Institutes of Health, USA

Thursday, March 25 | 8:00AM - 11:15AM
Steroid Receptors, Signaling and Cancer
Room: Grays Peak

Speaker 2 of 7
Kathryn B. Horwitz, University of Colorado Health Sciences Center, USA
Women’s Hormones, Breast Cancer Metastasis and Cancer Stem Cells

Thursday, March 25 | 8:00AM - 11:15AM
Steroid Receptors, Signaling and Cancer
Room: Grays Peak

Speaker 3 of 7
Jan-Åke Gustafsson, University of Houston, USA
Novel Biological Roles of LXRs

Thursday, March 25 | 8:00AM - 11:15AM
Steroid Receptors, Signaling and Cancer
Room: Grays Peak

Speaker 4 of 7
Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA
New Paradigms in Tumor Suppression: The RB-E2F Axis and Nuclear Receptor Regulation in Cancer

Thursday, March 25 | 8:00AM - 11:15AM
Steroid Receptors, Signaling and Cancer
Room: Grays Peak

Speaker 5 of 7
Charles L. Sawyers, Memorial Sloan-Kettering Cancer Center, USA
Overcoming Resistance to Anti-Androgen Therapy in Prostate Cancer

Thursday, March 25 | 8:00AM - 11:15AM
Steroid Receptors, Signaling and Cancer
Room: Grays Peak

Speaker 6 of 7
Yun Qiu, University of Maryland School of Medicine, USA
Short Talk: Androgen Receptor Splicing Variants and Castration Resistance in Prostate Cancer

Thursday, March 25 | 8:00AM - 11:15AM
Steroid Receptors, Signaling and Cancer
Room: Grays Peak

Speaker 7 of 7
Suzanne D. Conzen, University of Chicago, USA
Short Talk: Identification of a Glucocorticoid Receptor Signature in Primary Human Breast Cancers

Thursday, March 25 | 8:00AM - 11:15AM
Nuclear Receptors in Metabolism
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 1 of 6
Joyce J. Repa, University of Texas Southwestern Medical Center, USA
Nuclear Receptors in Pancreatic Beta Cells


Thursday, March 25 | 8:00AM - 11:15AM
Nuclear Receptors in Metabolism
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 2 of 6
Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
Regulation of Metabolism by Nuclear Receptor-FGF Pathways


Thursday, March 25 | 8:00AM - 11:15AM
Nuclear Receptors in Metabolism
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 3 of 6
Anastasia Kralli, Johns Hopkins Medical School, USA
ERR Function in Energy Metabolism and Cancer


Thursday, March 25 | 8:00AM - 11:15AM
Nuclear Receptors in Metabolism
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 4 of 6
* Vincent Giguère, McGill University, Canada
Metabolic Gene Networks in Normal and Cancer Cells: One Nuclear Receptor Subfamily to Rule them All


Thursday, March 25 | 8:00AM - 11:15AM
Nuclear Receptors in Metabolism
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 5 of 6
Carolyn L. Cummins, University of Toronto, Canada
Short Talk: LXRbeta is Required for Glucocorticoid-Induced Hyperglycemia and Hepatosteatosis


Thursday, March 25 | 8:00AM - 11:15AM
Nuclear Receptors in Metabolism
This session is from Nuclear Receptors: Development
Room: Longs Peak

Speaker 6 of 6
Yihong Wan, University of Texas Southwestern Medical Center, USA
Short Talk: PGC1beta Mediates PPARgamma Activation of Osteoclastogenesis and Rosiglitazone-Induced Bone Loss


Thursday, March 25 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, March 25 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Thursday, March 25 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, March 25 | 5:00PM - 7:00PM
Nuclear Receptors, Signaling, and Gene Regulation (Joint)
Room: Grays/Longs Peaks

Speaker 1 of 5
* Ronald M. Evans, HHMI/The Salk Institute, USA

Thursday, March 25 | 5:00PM - 7:00PM
Nuclear Receptors, Signaling, and Gene Regulation (Joint)
Room: Grays/Longs Peaks

Speaker 2 of 5
David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
Nutrient-Sensing and Metabolic Control by Nuclear Receptors

Thursday, March 25 | 5:00PM - 7:00PM
Nuclear Receptors, Signaling, and Gene Regulation (Joint)
Room: Grays/Longs Peaks

Speaker 3 of 5
Benita S. Katzenellenbogen, University of Illinois, USA
Genomics of Estrogen Receptor Signaling in Breast Cancer and Endocrine Resistance

Thursday, March 25 | 5:00PM - 7:00PM
Nuclear Receptors, Signaling, and Gene Regulation (Joint)
Room: Grays/Longs Peaks

Speaker 4 of 5
Myles Brown, Dana-Farber Cancer Institute, USA
Nuclear Receptor Cistromes and Epigenomes

Thursday, March 25 | 5:00PM - 7:00PM
Nuclear Receptors, Signaling, and Gene Regulation (Joint)
Room: Grays/Longs Peaks

Speaker 5 of 5
Edwin Cheung, University of Macau, Macau
Short Talk: Global and Funcational Analyses of ER-Mediated Long-Range Chromatin Interactions

Thursday, March 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Thursday, March 25 | 8:00PM - 11:00PM
Entertainment
Room: Shavano/Torreys


Thursday, March 25 | 8:00PM - 11:00PM
Cash Bar
Room: Shavano/Torreys


Friday, March 26 | 10:25AM - 10:25AM
Departure


*Session Chair.