Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Cancer Immunotherapy: Immunity and Immunosuppression Meet Targeted Therapies (2016J6)

Web Desc
New Paradigms in Cancer Therapeutics joint with Integration of Developmental Signaling Pathways Organizer(s): Arul M. Chinnaiyan and William R. Sellers Date: March 23 - 28, 2010 Location: Fairmont Empress Victoria / Victoria Conference Centre, Victoria, BC, Canada Sponsored by Abbott Laboratories, Genentech BioOncology and sanofi-aventis Summary of Meeting: The advent of genome-scale profiling technologies has opened up the possibility of comprehensively monitoring multiple layers of molecular aberrations in cancer. Alterations in the epigenome, genome, transcriptome, proteome and metabolome have all been observed in tumor development. A number of key molecular pathways have been found to be altered during cancer progression. Pivotal questions in the field include: Can these novel pathways alone or in combination be effectively targeted in cancer? Can we identify molecular signatures that will facilitate personalized medicine? What are the innovative therapeutic modalities that can be employed to target these pathways? The goal of this meeting is to tackle promising new targets for cancer therapy. These include targets such as recurrent gene fusions, epigenetic pathways, and metabolic networks. We will also explore the use of molecular marker panels to select patients for treatment. A number of approaches to therapeutic targeting will be discussed including novel biologics and RNA interference. Scholarship Deadline: November 24 2009 Discounted Abstract Deadline: November 24 2009 Abstract Deadline: December 29 2009 Discounted Registration Deadline: January 25 2010 We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Micromet, Inc. Novartis Institutes for BioMedical Research Tekmira We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: We gratefully acknowledge the generous grant for this conference provided by: National Cancer Institute (NCI) Grant No. 1R13CA144367-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

New Paradigms in Cancer Therapeutics

joint with Integration of Developmental Signaling Pathways

Organizer(s): Arul M. Chinnaiyan and William R. Sellers

Date: March 23 - 28, 2010
Location: Fairmont Empress Victoria / Victoria Conference Centre, Victoria, BC, Canada

Sponsored by Abbott Laboratories, Genentech BioOncology and sanofi-aventis

Summary of Meeting:

The advent of genome-scale profiling technologies has opened up the possibility of comprehensively monitoring multiple layers of molecular aberrations in cancer. Alterations in the epigenome, genome, transcriptome, proteome and metabolome have all been observed in tumor development. A number of key molecular pathways have been found to be altered during cancer progression. Pivotal questions in the field include: Can these novel pathways alone or in combination be effectively targeted in cancer? Can we identify molecular signatures that will facilitate personalized medicine? What are the innovative therapeutic modalities that can be employed to target these pathways? The goal of this meeting is to tackle promising new targets for cancer therapy. These include targets such as recurrent gene fusions, epigenetic pathways, and metabolic networks. We will also explore the use of molecular marker panels to select patients for treatment. A number of approaches to therapeutic targeting will be discussed including novel biologics and RNA interference.

Scholarship Deadline: November 24 2009

Discounted Abstract Deadline: November 24 2009

Abstract Deadline: December 29 2009

Discounted Registration Deadline: January 25 2010

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Micromet, Inc.

Novartis Institutes for BioMedical Research

Tekmira

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA144367-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Tuesday, March 23 \| 3:00PM - 7:30PM Registration Room: Prefunction 2
Tuesday, March 23 \| 6:30PM - 7:30PM Refreshments Room: Prefunction 2
Tuesday, March 23 \| 7:30PM - 8:30PM Keynote Address (Joint) Room: Salon B-C Speaker 1 of 1 Hans C. Clevers, Hubrecht Institute, Netherlands Wnt, Lgr5 Stem Cells and Cancer
Wednesday, March 24 \| 7:00AM - 8:00AM Breakfast Room: Palm Court
Wednesday, March 24 \| 8:00AM - 11:15AM Epigenetic Targets in Cancer Room: Salon B Speaker 1 of 7 * Arul M. Chinnaiyan, University of Michigan, USA
Wednesday, March 24 \| 8:00AM - 11:15AM Epigenetic Targets in Cancer Room: Salon B Speaker 2 of 7 Patrick Trojer, Constellation Pharmaceuticals, USA Targeting the Dynamics of Histone Lysine Methylation
Wednesday, March 24 \| 8:00AM - 11:15AM Epigenetic Targets in Cancer Room: Salon B Speaker 3 of 7 Thea D. Tlsty, University of California, San Francisco, USA Reprogramming the Epigenome during Cancer Progression
Wednesday, March 24 \| 8:00AM - 11:15AM Epigenetic Targets in Cancer Room: Salon B Speaker 4 of 7 Peter A. Jones, Van Andel Research Institute, USA Cancer Epigenomics
Wednesday, March 24 \| 8:00AM - 11:15AM Epigenetic Targets in Cancer Room: Salon B Speaker 5 of 7 Jean-Pierre Issa, Temple University School of Medicine, USA Combinations Targeting Multiple Epigenetic Pathways
Wednesday, March 24 \| 8:00AM - 11:15AM Epigenetic Targets in Cancer Room: Salon B Speaker 6 of 7 Akihide Yoshimi, Graduate School of Medicine, University of Tokyo, Japan Short Talk: EVI1 Induces a Novel Epigenetic Regulation of PTEN/AKT/mTOR Signaling through Interaction with Polycomb Complexes in Leukemia
Wednesday, March 24 \| 8:00AM - 11:15AM Epigenetic Targets in Cancer Room: Salon B Speaker 7 of 7 Aliaksei Holik, Cardiff University, UK Short Talk: Chromatin Remodelling ATPase Brg-1 is an Essential Factor for the Maintenance of the Intestinal Crypt Stem Cell and Wnt Driven Adenoma Formation
Wednesday, March 24 \| 8:00AM - 11:15AM Integrating Signal Gradients in Development This session is from Signaling Pathways Room: Salon C Hh vs. Wnt or TGFbeta, Notch, etc. in developing Neural Tube, Fly Wing Imaginal Disc., A/P or D/V Polarity etc. Speaker 1 of 6 * Elaine V. Fuchs, Rockefeller University, USA
Wednesday, March 24 \| 8:00AM - 11:15AM Integrating Signal Gradients in Development This session is from Signaling Pathways Room: Salon C Hh vs. Wnt or TGFbeta, Notch, etc. in developing Neural Tube, Fly Wing Imaginal Disc., A/P or D/V Polarity etc. Speaker 2 of 6 Jean-Denis Benazet, University of Southern California, USA Interlinked Signaling Feedback Loops and Self-Regulation during Mouse Limb Development
Wednesday, March 24 \| 8:00AM - 11:15AM Integrating Signal Gradients in Development This session is from Signaling Pathways Room: Salon C Hh vs. Wnt or TGFbeta, Notch, etc. in developing Neural Tube, Fly Wing Imaginal Disc., A/P or D/V Polarity etc. Speaker 3 of 6 Xi He, Harvard Medical School, USA Mechanisms of Wnt Signaling and Regulation
Wednesday, March 24 \| 8:00AM - 11:15AM Integrating Signal Gradients in Development This session is from Signaling Pathways Room: Salon C Hh vs. Wnt or TGFbeta, Notch, etc. in developing Neural Tube, Fly Wing Imaginal Disc., A/P or D/V Polarity etc. Speaker 4 of 6 Chi-chung Hui, Hospital for Sick Children, Canada Regulators of Gli Transcription Factors in Development and Cancer
Wednesday, March 24 \| 8:00AM - 11:15AM Integrating Signal Gradients in Development This session is from Signaling Pathways Room: Salon C Hh vs. Wnt or TGFbeta, Notch, etc. in developing Neural Tube, Fly Wing Imaginal Disc., A/P or D/V Polarity etc. Speaker 5 of 6 Brandon J. Wainwright, University of Queensland, Australia The Intersection between Hedgehog and Notch Signaling in Development and Cancer
Wednesday, March 24 \| 8:00AM - 11:15AM Integrating Signal Gradients in Development This session is from Signaling Pathways Room: Salon C Hh vs. Wnt or TGFbeta, Notch, etc. in developing Neural Tube, Fly Wing Imaginal Disc., A/P or D/V Polarity etc. Speaker 6 of 6 Elizabeth Ann Grove, University of Chicago, USA Signaling Gradients in Patterning the Mammalian Cerebral Cortex
Wednesday, March 24 \| 9:20AM - 9:40AM Coffee Break Room: Prefunction 2
Wednesday, March 24 \| 11:15AM - 11:15AM On Own for Lunch and Recreation
Wednesday, March 24 \| 11:15AM - 1:00PM Poster Setup Room: Salon A
Wednesday, March 24 \| 1:00PM - 10:00PM Poster Viewing Room: Salon A
Wednesday, March 24 \| 4:30PM - 5:00PM Coffee Available Room: Prefunction 2
Wednesday, March 24 \| 5:00PM - 7:00PM Predictive Signatures for Cancer Room: Salon B Speaker 1 of 4 Levi A. Garraway, Genentech, Inc, USA High-Throughput Oncogene Mutation Profiling in Human Cancer
Wednesday, March 24 \| 5:00PM - 7:00PM Predictive Signatures for Cancer Room: Salon B Speaker 2 of 4 Joe W. Gray, Oregon Health and Science University, USA Omics Based Approaches to Predict Cancer Therapy
Wednesday, March 24 \| 5:00PM - 7:00PM Predictive Signatures for Cancer Room: Salon B Speaker 3 of 4 William R. Sellers, Broad Institute of MIT and Harvard, USA Connecting Patients to Therapy: Functional and Comparative Approaches to Translational Oncology
Wednesday, March 24 \| 5:00PM - 7:00PM Predictive Signatures for Cancer Room: Salon B Speaker 4 of 4 Daniel R. Rhodes, University of Michigan, USA Short Talk: Somatic Mutations in Human Cancer Cell Lines Predict Sorafenib Response
Wednesday, March 24 \| 5:00PM - 7:00PM Mechanisms of Signal Integration I - Hippo Pathway and Cilia This session is from Signaling Pathways Room: Salon C Speaker 1 of 5 * Ken M. Cadigan, University of Michigan, USA
Wednesday, March 24 \| 5:00PM - 7:00PM Mechanisms of Signal Integration I - Hippo Pathway and Cilia This session is from Signaling Pathways Room: Salon C Speaker 2 of 5 Jeremy F. Reiter, University of California, San Francisco, USA Primary Cilia Transduce Hedgehog Signals in Both Development and Cancer
Wednesday, March 24 \| 5:00PM - 7:00PM Mechanisms of Signal Integration I - Hippo Pathway and Cilia This session is from Signaling Pathways Room: Salon C Speaker 3 of 5 Elaine V. Fuchs, Rockefeller University, USA Developmental Signaling Pathways in the Skin
Wednesday, March 24 \| 5:00PM - 7:00PM Mechanisms of Signal Integration I - Hippo Pathway and Cilia This session is from Signaling Pathways Room: Salon C Speaker 4 of 5 Helen McNeill, Lunenfeld-Tanenbaum Research Institute, Canada Fat Cadherins in the Regulation of Growth and Planar Cell Polarity
Wednesday, March 24 \| 5:00PM - 7:00PM Mechanisms of Signal Integration I - Hippo Pathway and Cilia This session is from Signaling Pathways Room: Salon C Speaker 5 of 5 Rhonda Hui Ping Kan, Institute for Molecular Bioscience, Australia Short Talk: N-myc and C-myc are Functionally Redundant in Mediating the Effects of Ptch1 Mutation in Epidermis
Wednesday, March 24 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Salon A
Wednesday, March 24 \| 7:30PM - 10:00PM Poster Session 1 Room: Salon A
Thursday, March 25 \| 7:00AM - 8:00AM Breakfast Room: Palm Court
Thursday, March 25 \| 8:00AM - 11:15AM Targeting Developmental Pathways in Cancer (Joint) Room: Salon B-C Speaker 1 of 5 * Marion Dorsch, Blueprint Medicines Corporation, USA Hedgehog Inhibitors
Thursday, March 25 \| 8:00AM - 11:15AM Targeting Developmental Pathways in Cancer (Joint) Room: Salon B-C Speaker 2 of 5 Thomas Thomas Look, Dana-Farber Cancer Institute, USA Activating Mutations in the ALK Tyrosine Kinase Provide a Therapeutic Target in Neuroblastoma
Thursday, March 25 \| 8:00AM - 11:15AM Targeting Developmental Pathways in Cancer (Joint) Room: Salon B-C Speaker 3 of 5 Luisa Iruela-Arispe, University of California, Los Angeles, USA Angiogenesis, Developmental Pathways and Cancer
Thursday, March 25 \| 8:00AM - 11:15AM Targeting Developmental Pathways in Cancer (Joint) Room: Salon B-C Speaker 4 of 5 James F. Amatruda, University of Texas Southwestern Medical Center, USA Short Talk: BMP Signaling in Germ Cell Differentiation and Germ Cell Tumors
Thursday, March 25 \| 8:00AM - 11:15AM Targeting Developmental Pathways in Cancer (Joint) Room: Salon B-C Speaker 5 of 5 Leni S. Jacob, Memorial Sloan-Kettering Cancer Center, USA Short Talk: Assignment of Aberrant Hedgehog and Wnt Pathway Activity to Disease by Genome-Wide RNAi in Cultured Cells
Thursday, March 25 \| 9:20AM - 9:40AM Coffee Break Room: Prefunction 2
Thursday, March 25 \| 11:15AM - 11:15AM On Own for Lunch and Recreation
Thursday, March 25 \| 11:15AM - 1:00PM Poster Setup Room: Salon A
Thursday, March 25 \| 1:00PM - 10:00PM Poster Viewing Room: Salon A
Thursday, March 25 \| 4:30PM - 5:00PM Coffee Available Room: Prefunction 2
Thursday, March 25 \| 5:00PM - 7:00PM Recurrent Gene Fusions as Cancer Therapeutic Targets Room: Salon B Speaker 1 of 5 * Levi A. Garraway, Genentech, Inc, USA
Thursday, March 25 \| 5:00PM - 7:00PM Recurrent Gene Fusions as Cancer Therapeutic Targets Room: Salon B Speaker 2 of 5 Hiroyuki Mano, University of Tokyo, Japan Targeting the ALK Fusion Genes in Lung Cancer
Thursday, March 25 \| 5:00PM - 7:00PM Recurrent Gene Fusions as Cancer Therapeutic Targets Room: Salon B Speaker 3 of 5 Arul M. Chinnaiyan, University of Michigan, USA Targeting Gene Fusions in Prostate Cancer
Thursday, March 25 \| 5:00PM - 7:00PM Recurrent Gene Fusions as Cancer Therapeutic Targets Room: Salon B Speaker 4 of 5 Yardena Samuels, Weizmann Institute of Science, Israel Mutational Analysis of the Melanoma Genome
Thursday, March 25 \| 5:00PM - 7:00PM Recurrent Gene Fusions as Cancer Therapeutic Targets Room: Salon B Speaker 5 of 5 Yoshihiro Yamashita, University of Tokyo, Japan Short Talk: Array-based Genomic Resequencing of Acute Myeloid Leukemia
Thursday, March 25 \| 5:00PM - 7:00PM Mechanisms of Signal Integration II - Coordinated Proteolysi s This session is from Signaling Pathways Room: Salon C Speaker 1 of 5 * Xi He, Harvard Medical School, USA
Thursday, March 25 \| 5:00PM - 7:00PM Mechanisms of Signal Integration II - Coordinated Proteolysi s This session is from Signaling Pathways Room: Salon C Speaker 2 of 5 Randall T. Moon, University of Washington School of Medicine, USA Elucidating Wnt/beta-Catenin Signaling Networks by Integrated siRNA, Proteomic, and Small Molecule Screens
Thursday, March 25 \| 5:00PM - 7:00PM Mechanisms of Signal Integration II - Coordinated Proteolysi s This session is from Signaling Pathways Room: Salon C Speaker 3 of 5 Jin Jiang, University of Texas Southwestern Medical Center, USA Kinase Regulation of Hedgehog Signaling
Thursday, March 25 \| 5:00PM - 7:00PM Mechanisms of Signal Integration II - Coordinated Proteolysi s This session is from Signaling Pathways Room: Salon C Speaker 4 of 5 Ying E. Zhang, NCI, National Institutes of Health, USA Proteolysis in TGF-beta Signaling and Cancer
Thursday, March 25 \| 5:00PM - 7:00PM Mechanisms of Signal Integration II - Coordinated Proteolysi s This session is from Signaling Pathways Room: Salon C Speaker 5 of 5 Masahiro Narimatsu, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Canada Short Talk: Smurf Ubiqutin Ligases are Required for Embryo Patterning during Gastrulation
Thursday, March 25 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Salon A
Thursday, March 25 \| 7:30PM - 10:00PM Poster Session 2 Room: Salon A
Friday, March 26 \| 7:00AM - 8:00AM Breakfast Room: Palm Court
Friday, March 26 \| 8:00AM - 11:00AM Toward Rational Targeted Combination Therapy Room: Salon B Speaker 1 of 6 * Arul M. Chinnaiyan, University of Michigan, USA
Friday, March 26 \| 8:00AM - 11:00AM Toward Rational Targeted Combination Therapy Room: Salon B Speaker 2 of 6 Kenneth P. Nephew, Indiana University, USA DNA Methylation Inhibitors for Chemotherapy Resensitization of Solid Tumors
Friday, March 26 \| 8:00AM - 11:00AM Toward Rational Targeted Combination Therapy Room: Salon B Speaker 3 of 6 Paul G. Polakis, Genentech, Inc., USA Wnt Antagonists in Cancer
Friday, March 26 \| 8:00AM - 11:00AM Toward Rational Targeted Combination Therapy Room: Salon B Speaker 4 of 6 Shaomeng Wang, University of Michigan, USA Current Targeting of Multiple Key Apoptosis Regulators is Required to Efficiently Kill Tumor Cells
Friday, March 26 \| 8:00AM - 11:00AM Toward Rational Targeted Combination Therapy Room: Salon B Speaker 5 of 6 Caroline M. Emery, Dana Farber Cancer Institute, USA Short Talk: Genetic Studies of Resistance to MEK and BRAF Inhibition
Friday, March 26 \| 8:00AM - 11:00AM Toward Rational Targeted Combination Therapy Room: Salon B Speaker 6 of 6 Jinyan Du, Dragonfly Therapeutics, USA Short Talk: Systematic Characterization of Pathway Interactions with ER Signaling in Human Mammary Carcinomas
Friday, March 26 \| 8:00AM - 11:00AM Mechanisms of Integration III - Transcriptional Regulation a nd/or Epigenetics/Reversible Histone Methylation This session is from Signaling Pathways Room: Salon C Speaker 1 of 7 * Austin Smith, University of Cambridge, UK
Friday, March 26 \| 8:00AM - 11:00AM Mechanisms of Integration III - Transcriptional Regulation a nd/or Epigenetics/Reversible Histone Methylation This session is from Signaling Pathways Room: Salon C Speaker 2 of 7 Michael D. Taylor, Hospital for Sick Children, Canada A Role for Histone Lysine Methylation in the Pathogenesis of Pediatric Brain Tumors?
Friday, March 26 \| 8:00AM - 11:00AM Mechanisms of Integration III - Transcriptional Regulation a nd/or Epigenetics/Reversible Histone Methylation This session is from Signaling Pathways Room: Salon C Speaker 3 of 7 Marion Dorsch, Blueprint Medicines Corporation, USA Smoothened Antagonists: Anticipating and Treating Resistance
Friday, March 26 \| 8:00AM - 11:00AM Mechanisms of Integration III - Transcriptional Regulation a nd/or Epigenetics/Reversible Histone Methylation This session is from Signaling Pathways Room: Salon C Speaker 4 of 7 Ken M. Cadigan, University of Michigan, USA Selection of Wnt Targets and Subsequent Chromatin Modifications
Friday, March 26 \| 8:00AM - 11:00AM Mechanisms of Integration III - Transcriptional Regulation a nd/or Epigenetics/Reversible Histone Methylation This session is from Signaling Pathways Room: Salon C Speaker 5 of 7 Feng Cong, Novartis Institutes for BioMedical Research, USA Short Talk: Targeting Wnt Signaling through TNKS Inhibition and Axin Stabilization
Friday, March 26 \| 8:00AM - 11:00AM Mechanisms of Integration III - Transcriptional Regulation a nd/or Epigenetics/Reversible Histone Methylation This session is from Signaling Pathways Room: Salon C Speaker 6 of 7 Felix Lohmann, Novartis Institutes for BioMedical Research, Switzerland Short Talk: KMT1E Mediated H3K9 Methylation is Required for the Maintenance of Embryonic Stem Cells by Repressing Trophectoderm Differentiation
Friday, March 26 \| 8:00AM - 11:00AM Mechanisms of Integration III - Transcriptional Regulation a nd/or Epigenetics/Reversible Histone Methylation This session is from Signaling Pathways Room: Salon C Speaker 7 of 7 Robert Rottapel, Princess Margaret Hospital, Toronto Medical Discovery Tower, Canada Short Talk: Tankyrase Functions as a Cross-Regulator of Signalling Pathways
Friday, March 26 \| 9:20AM - 9:40AM Coffee Break Room: Prefunction 2
Friday, March 26 \| 11:15AM - 11:15AM On Own for Lunch and Recreation
Friday, March 26 \| 4:30PM - 5:00PM Coffee Available Room: Prefunction 2
Friday, March 26 \| 5:00PM - 7:00PM Targeting Metabolic Pathways in Cancer Room: Salon B Speaker 1 of 5 * Luisa Iruela-Arispe, University of California, Los Angeles, USA
Friday, March 26 \| 5:00PM - 7:00PM Targeting Metabolic Pathways in Cancer Room: Salon B Speaker 2 of 5 Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA Targeting Cancer Cell Metabolism
Friday, March 26 \| 5:00PM - 7:00PM Targeting Metabolic Pathways in Cancer Room: Salon B Speaker 3 of 5 Valeria Fantin, ORIC Pharmaceuticals, USA Cancer-Associated IDH1 Mutations Produce 2-Hydroyxglutarate
Friday, March 26 \| 5:00PM - 7:00PM Targeting Metabolic Pathways in Cancer Room: Salon B Speaker 4 of 5 Patrick S. Ward, Massachusetts General Hospital, USA Short Talk: The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations is a Neomorphic Enzyme Activity Converting alpha-Ketoglutarate to 2-Hydroxyglutarate
Friday, March 26 \| 5:00PM - 7:00PM Targeting Metabolic Pathways in Cancer Room: Salon B Speaker 5 of 5 Amjad Pervez Khan, University of Michigan, USA Short Talk: Metabolomic Profiling Delineate Polyamines as Biomarkers for Prostate Cancer Progression
Friday, March 26 \| 5:00PM - 7:00PM Stem Cell Fate and Signaling This session is from Signaling Pathways Room: Salon C Speaker 1 of 5 * Morag Park, McGill University, Canada
Friday, March 26 \| 5:00PM - 7:00PM Stem Cell Fate and Signaling This session is from Signaling Pathways Room: Salon C Speaker 2 of 5 Jim Woodgett, Mount Sinai Hospital, Canada Coordinate Regulation of Multiple Signaling Pathways and Differentiation Processes by Glycogen Synthase Kinase-3
Friday, March 26 \| 5:00PM - 7:00PM Stem Cell Fate and Signaling This session is from Signaling Pathways Room: Salon C Speaker 3 of 5 Austin Smith, University of Cambridge, UK Intrinsic and Extrinsic Regulation of the Pluripotent Ground State
Friday, March 26 \| 5:00PM - 7:00PM Stem Cell Fate and Signaling This session is from Signaling Pathways Room: Salon C Speaker 4 of 5 Jeffrey L. Wrana, Mount Sinai Hospital, Canada Cell Fate and Polarity Signals
Friday, March 26 \| 5:00PM - 7:00PM Stem Cell Fate and Signaling This session is from Signaling Pathways Room: Salon C Speaker 5 of 5 Rita Lukacs, Takeda California, USA Short Talk: Bmi-1 is a Dominant Self-Renewal Gene in the Murine Prostate that Controls both Stem Cell Maintenance and Cancer Initiation
Friday, March 26 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Salon A
Saturday, March 27 \| 7:00AM - 8:00AM Breakfast Room: Palm Court
Saturday, March 27 \| 8:00AM - 11:00AM siRNA Therapeutics Room: Salon B Speaker 1 of 7 * William R. Sellers, Broad Institute of MIT and Harvard, USA
Saturday, March 27 \| 8:00AM - 11:00AM siRNA Therapeutics Room: Salon B Speaker 2 of 7 Daniel G. Anderson, Massachusetts Institute of Technology, USA Combinatorial Development of Biomaterials and Synthetic siRNA Delivery Systems
Saturday, March 27 \| 8:00AM - 11:00AM siRNA Therapeutics Room: Salon B Speaker 3 of 7 Ian MacLachlan, Tekmira Pharmaceuticals Corp., Canada Therapeutic Silencing of Polo-Like Kinase 1 and Kinesin Spindle Protein via the Confirmed Mechanism of RNA Interference
Saturday, March 27 \| 8:00AM - 11:00AM siRNA Therapeutics Room: Salon B Speaker 4 of 7 John J. Rossi, Beckman Research Institute of the City of Hope, USA Strategies for RNA Interference (RNAi) Applications in Cancer Therapy
Saturday, March 27 \| 8:00AM - 11:00AM siRNA Therapeutics Room: Salon B Speaker 5 of 7 Eric Marcusson, Providence Therapeutics, USA Short Talk: microRNA Mimics as Cancer Therapeutics
Saturday, March 27 \| 8:00AM - 11:00AM siRNA Therapeutics Room: Salon B Speaker 6 of 7 Steven Blake, University of North Carolina at Chapel Hill, USA Short Talk: Targeted Delivery of siRNA using PRINT® Particles
Saturday, March 27 \| 8:00AM - 11:00AM siRNA Therapeutics Room: Salon B Speaker 7 of 7 Kathy L. Fosnaugh, Aminex Therapeutics, Inc., USA Short Talk: Development of siRNA Therapeutics for Treatment of Bladder Cancer and Hepatocellular Carcinoma
Saturday, March 27 \| 8:00AM - 11:00AM Integrated Signaling in Tumor/Stromal Interaction This session is from Signaling Pathways Room: Salon C Emerging stories around tumors and stroma feeding each other signals and each changing to reinforce cancer. Speaker 1 of 6 * Jeffrey L. Wrana, Mount Sinai Hospital, Canada
Saturday, March 27 \| 8:00AM - 11:00AM Integrated Signaling in Tumor/Stromal Interaction This session is from Signaling Pathways Room: Salon C Emerging stories around tumors and stroma feeding each other signals and each changing to reinforce cancer. Speaker 2 of 6 Morag Park, McGill University, Canada Breast Tumor Microenvironment: Impact on Tumor Heterogeneity and Outcome
Saturday, March 27 \| 8:00AM - 11:00AM Integrated Signaling in Tumor/Stromal Interaction This session is from Signaling Pathways Room: Salon C Emerging stories around tumors and stroma feeding each other signals and each changing to reinforce cancer. Speaker 3 of 6 John Condeelis, Albert Einstein College of Medicine, USA The Tumor Microenvironment Invasion Signature: Effects on Tumor Cell Plasticity in vivo
Saturday, March 27 \| 8:00AM - 11:00AM Integrated Signaling in Tumor/Stromal Interaction This session is from Signaling Pathways Room: Salon C Emerging stories around tumors and stroma feeding each other signals and each changing to reinforce cancer. Speaker 4 of 6 Christine Dierks-Ventling, Friedrich Miescher Institut, Switzerland Hedgehog Signaling in Hematologic Malignancies
Saturday, March 27 \| 8:00AM - 11:00AM Integrated Signaling in Tumor/Stromal Interaction This session is from Signaling Pathways Room: Salon C Emerging stories around tumors and stroma feeding each other signals and each changing to reinforce cancer. Speaker 5 of 6 Minoti Apte, University of New South Wales, Australia Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells
Saturday, March 27 \| 8:00AM - 11:00AM Integrated Signaling in Tumor/Stromal Interaction This session is from Signaling Pathways Room: Salon C Emerging stories around tumors and stroma feeding each other signals and each changing to reinforce cancer. Speaker 6 of 6 Gabri Van der Pluijm, Leiden University Medical Center, Netherlands Short Talk: TGFbeta-BMP7 Interactions in Bone Metastasis; Potential Therapeutic Implications
Saturday, March 27 \| 9:20AM - 9:40AM Coffee Break Room: Prefunction 2
Saturday, March 27 \| 11:00AM - 11:00AM On Own for Lunch and Recreation
Saturday, March 27 \| 4:30PM - 5:00PM Coffee Available Room: Prefunction 2
Saturday, March 27 \| 5:00PM - 7:00PM Novel Biologic and Virus Based Cancer Therapeutics Room: Salon B Speaker 1 of 6 * William R. Sellers, Broad Institute of MIT and Harvard, USA
Saturday, March 27 \| 5:00PM - 7:00PM Novel Biologic and Virus Based Cancer Therapeutics Room: Salon B Speaker 2 of 6 Serge Muyldermans, Vrije Universiteit Brussel, Belgium Camelid Nanobodies for Cancer and Diagnostic Assay Development
Saturday, March 27 \| 5:00PM - 7:00PM Novel Biologic and Virus Based Cancer Therapeutics Room: Salon B Speaker 3 of 6 Patrick A. Baeuerle, Amgen Research (Munich) GmbH, Germany Engaging T Cells for Cancer Therapy by Bispecific Antibodies
Saturday, March 27 \| 5:00PM - 7:00PM Novel Biologic and Virus Based Cancer Therapeutics Room: Salon B Speaker 4 of 6 Sunjoo Jeong, Dankook University, South Korea Short Talk: RNA Aptamers for the Modulation of Wnt/beta-catenin Signaling
Saturday, March 27 \| 5:00PM - 7:00PM Novel Biologic and Virus Based Cancer Therapeutics Room: Salon B Speaker 5 of 6 Mohammad Qadir, BC Cancer Agency, Canada Short Talk:
Saturday, March 27 \| 5:00PM - 7:00PM Novel Biologic and Virus Based Cancer Therapeutics Room: Salon B Speaker 6 of 6 Sandra E. Dunn, University of British Columbia, Canada Short Talk:
Saturday, March 27 \| 5:00PM - 7:00PM Aberrant Signal Interactions and Disease This session is from Signaling Pathways Room: Salon C Speaker 1 of 5 * Jim Woodgett, Mount Sinai Hospital, Canada
Saturday, March 27 \| 5:00PM - 7:00PM Aberrant Signal Interactions and Disease This session is from Signaling Pathways Room: Salon C Speaker 2 of 5 Geraldine Weinmaster, David Geffen School of Medicine at UCLA, USA Ligand Endocytosis and Force Generation in Activation of Notch Signaling
Saturday, March 27 \| 5:00PM - 7:00PM Aberrant Signal Interactions and Disease This session is from Signaling Pathways Room: Salon C Speaker 3 of 5 Bruce A. Edgar, German Cancer Research Center, Germany Signaling and Stem Cell Control in the Drosophila Intestine
Saturday, March 27 \| 5:00PM - 7:00PM Aberrant Signal Interactions and Disease This session is from Signaling Pathways Room: Salon C Speaker 4 of 5 Adolfo Ferrando, Columbia University, USA NOTCH1 Transcriptional Networks in Human Leukemia
Saturday, March 27 \| 5:00PM - 7:00PM Aberrant Signal Interactions and Disease This session is from Signaling Pathways Room: Salon C Speaker 5 of 5 Daniela F. Quail, McGill University, Canada Short Talk: Nodal Promotes Metastasis and Stem Cell Phenotypes in Breast Cancer
Saturday, March 27 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Palm Court
Saturday, March 27 \| 8:00PM - 11:00PM Entertainment Room: Palm Court
Saturday, March 27 \| 8:00PM - 11:00PM Cash Bar Room: Palm Court
Sunday, March 28 \| 10:25AM - 10:25AM Departure *Session Chair.