Web Desc
New Paradigms in Cancer Therapeutics
joint with Integration of Developmental Signaling Pathways
Organizer(s): Arul M. Chinnaiyan and William R. Sellers
Date: March 23 - 28, 2010
Location: Fairmont Empress Victoria / Victoria Conference Centre, Victoria, BC, Canada
Sponsored by Abbott Laboratories, Genentech BioOncology and sanofi-aventis
Summary of Meeting:
The advent of genome-scale profiling technologies has opened up the possibility of comprehensively monitoring multiple layers of molecular aberrations in cancer. Alterations in the epigenome, genome, transcriptome, proteome and metabolome have all been observed in tumor development. A number of key molecular pathways have been found to be altered during cancer progression. Pivotal questions in the field include: Can these novel pathways alone or in combination be effectively targeted in cancer? Can we identify molecular signatures that will facilitate personalized medicine? What are the innovative therapeutic modalities that can be employed to target these pathways? The goal of this meeting is to tackle promising new targets for cancer therapy. These include targets such as recurrent gene fusions, epigenetic pathways, and metabolic networks. We will also explore the use of molecular marker panels to select patients for treatment. A number of approaches to therapeutic targeting will be discussed including novel biologics and RNA interference.
Scholarship Deadline: November 24 2009
Discounted Abstract Deadline: November 24 2009
Abstract Deadline: December 29 2009
Discounted Registration Deadline: January 25 2010
We gratefully acknowledge additional support for this conference from:
Abbott LaboratoriesCell Signaling Technology, Inc.Exelixis, Inc.Genentech BioOncologySanofi US
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Micromet, Inc.

Novartis Institutes for BioMedical Research

Tekmira
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
ACS Publications
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA144367-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, March 23 | 3:00PM - 7:30PM
Registration
Room: Prefunction 2


Tuesday, March 23 | 6:30PM - 7:30PM
Refreshments
Room: Prefunction 2


Tuesday, March 23 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: Salon B-C

Speaker 1 of 1
Hans C. Clevers, Hubrecht Institute, Netherlands
Wnt, Lgr5 Stem Cells and Cancer

Wednesday, March 24 | 7:00AM - 8:00AM
Breakfast
Room: Palm Court


Wednesday, March 24 | 8:00AM - 11:15AM
Epigenetic Targets in Cancer
Room: Salon B

Speaker 1 of 7
* Arul M. Chinnaiyan, University of Michigan, USA

Wednesday, March 24 | 8:00AM - 11:15AM
Epigenetic Targets in Cancer
Room: Salon B

Speaker 2 of 7
Patrick Trojer, Constellation Pharmaceuticals, USA
Targeting the Dynamics of Histone Lysine Methylation

Wednesday, March 24 | 8:00AM - 11:15AM
Epigenetic Targets in Cancer
Room: Salon B

Speaker 3 of 7
Thea D. Tlsty, University of California, San Francisco, USA
Reprogramming the Epigenome during Cancer Progression

Wednesday, March 24 | 8:00AM - 11:15AM
Epigenetic Targets in Cancer
Room: Salon B

Speaker 4 of 7
Peter A. Jones, Van Andel Research Institute, USA
Cancer Epigenomics

Wednesday, March 24 | 8:00AM - 11:15AM
Epigenetic Targets in Cancer
Room: Salon B

Speaker 5 of 7
Jean-Pierre Issa, Temple University School of Medicine, USA
Combinations Targeting Multiple Epigenetic Pathways

Wednesday, March 24 | 8:00AM - 11:15AM
Epigenetic Targets in Cancer
Room: Salon B

Speaker 6 of 7
Akihide Yoshimi, Graduate School of Medicine, University of Tokyo, Japan
Short Talk: EVI1 Induces a Novel Epigenetic Regulation of PTEN/AKT/mTOR Signaling through Interaction with Polycomb Complexes in Leukemia

Wednesday, March 24 | 8:00AM - 11:15AM
Epigenetic Targets in Cancer
Room: Salon B

Speaker 7 of 7
Aliaksei Holik, Cardiff University, UK
Short Talk: Chromatin Remodelling ATPase Brg-1 is an Essential Factor for the Maintenance of the Intestinal Crypt Stem Cell and Wnt Driven Adenoma Formation

Wednesday, March 24 | 8:00AM - 11:15AM
Integrating Signal Gradients in Development
This session is from Signaling Pathways
Room: Salon C
Hh vs. Wnt or TGFbeta, Notch, etc. in developing Neural Tube, Fly Wing Imaginal Disc., A/P or D/V Polarity etc.
Speaker 1 of 6
* Elaine V. Fuchs, Rockefeller University, USA


Wednesday, March 24 | 8:00AM - 11:15AM
Integrating Signal Gradients in Development
This session is from Signaling Pathways
Room: Salon C
Hh vs. Wnt or TGFbeta, Notch, etc. in developing Neural Tube, Fly Wing Imaginal Disc., A/P or D/V Polarity etc.
Speaker 2 of 6
Jean-Denis Benazet, University of Southern California, USA
Interlinked Signaling Feedback Loops and Self-Regulation during Mouse Limb Development


Wednesday, March 24 | 8:00AM - 11:15AM
Integrating Signal Gradients in Development
This session is from Signaling Pathways
Room: Salon C
Hh vs. Wnt or TGFbeta, Notch, etc. in developing Neural Tube, Fly Wing Imaginal Disc., A/P or D/V Polarity etc.
Speaker 3 of 6
Xi He, Harvard Medical School, USA
Mechanisms of Wnt Signaling and Regulation


Wednesday, March 24 | 8:00AM - 11:15AM
Integrating Signal Gradients in Development
This session is from Signaling Pathways
Room: Salon C
Hh vs. Wnt or TGFbeta, Notch, etc. in developing Neural Tube, Fly Wing Imaginal Disc., A/P or D/V Polarity etc.
Speaker 4 of 6
Chi-chung Hui, Hospital for Sick Children, Canada
Regulators of Gli Transcription Factors in Development and Cancer


Wednesday, March 24 | 8:00AM - 11:15AM
Integrating Signal Gradients in Development
This session is from Signaling Pathways
Room: Salon C
Hh vs. Wnt or TGFbeta, Notch, etc. in developing Neural Tube, Fly Wing Imaginal Disc., A/P or D/V Polarity etc.
Speaker 5 of 6
Brandon J. Wainwright, University of Queensland, Australia
The Intersection between Hedgehog and Notch Signaling in Development and Cancer


Wednesday, March 24 | 8:00AM - 11:15AM
Integrating Signal Gradients in Development
This session is from Signaling Pathways
Room: Salon C
Hh vs. Wnt or TGFbeta, Notch, etc. in developing Neural Tube, Fly Wing Imaginal Disc., A/P or D/V Polarity etc.
Speaker 6 of 6
Elizabeth Ann Grove, University of Chicago, USA
Signaling Gradients in Patterning the Mammalian Cerebral Cortex


Wednesday, March 24 | 9:20AM - 9:40AM
Coffee Break
Room: Prefunction 2


Wednesday, March 24 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, March 24 | 11:15AM - 1:00PM
Poster Setup
Room: Salon A


Wednesday, March 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Salon A


Wednesday, March 24 | 4:30PM - 5:00PM
Coffee Available
Room: Prefunction 2


Wednesday, March 24 | 5:00PM - 7:00PM
Predictive Signatures for Cancer
Room: Salon B

Speaker 1 of 4
Levi A. Garraway, Genentech, Inc, USA
High-Throughput Oncogene Mutation Profiling in Human Cancer

Wednesday, March 24 | 5:00PM - 7:00PM
Predictive Signatures for Cancer
Room: Salon B

Speaker 2 of 4
Joe W. Gray, Oregon Health and Science University, USA
Omics Based Approaches to Predict Cancer Therapy

Wednesday, March 24 | 5:00PM - 7:00PM
Predictive Signatures for Cancer
Room: Salon B

Speaker 3 of 4
William R. Sellers, Broad Institute of MIT and Harvard, USA
Connecting Patients to Therapy: Functional and Comparative Approaches to Translational Oncology

Wednesday, March 24 | 5:00PM - 7:00PM
Predictive Signatures for Cancer
Room: Salon B

Speaker 4 of 4
Daniel R. Rhodes, University of Michigan, USA
Short Talk: Somatic Mutations in Human Cancer Cell Lines Predict Sorafenib Response

Wednesday, March 24 | 5:00PM - 7:00PM
Mechanisms of Signal Integration I - Hippo Pathway and Cilia
This session is from Signaling Pathways
Room: Salon C

Speaker 1 of 5
* Ken M. Cadigan, University of Michigan, USA


Wednesday, March 24 | 5:00PM - 7:00PM
Mechanisms of Signal Integration I - Hippo Pathway and Cilia
This session is from Signaling Pathways
Room: Salon C

Speaker 2 of 5
Jeremy F. Reiter, University of California, San Francisco, USA
Primary Cilia Transduce Hedgehog Signals in Both Development and Cancer


Wednesday, March 24 | 5:00PM - 7:00PM
Mechanisms of Signal Integration I - Hippo Pathway and Cilia
This session is from Signaling Pathways
Room: Salon C

Speaker 3 of 5
Elaine V. Fuchs, Rockefeller University, USA
Developmental Signaling Pathways in the Skin


Wednesday, March 24 | 5:00PM - 7:00PM
Mechanisms of Signal Integration I - Hippo Pathway and Cilia
This session is from Signaling Pathways
Room: Salon C

Speaker 4 of 5
Helen McNeill, Lunenfeld-Tanenbaum Research Institute, Canada
Fat Cadherins in the Regulation of Growth and Planar Cell Polarity


Wednesday, March 24 | 5:00PM - 7:00PM
Mechanisms of Signal Integration I - Hippo Pathway and Cilia
This session is from Signaling Pathways
Room: Salon C

Speaker 5 of 5
Rhonda Hui Ping Kan, Institute for Molecular Bioscience, Australia
Short Talk: N-myc and C-myc are Functionally Redundant in Mediating the Effects of Ptch1 Mutation in Epidermis


Wednesday, March 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Salon A


Wednesday, March 24 | 7:30PM - 10:00PM
Poster Session 1
Room: Salon A


Thursday, March 25 | 7:00AM - 8:00AM
Breakfast
Room: Palm Court


Thursday, March 25 | 8:00AM - 11:15AM
Targeting Developmental Pathways in Cancer (Joint)
Room: Salon B-C

Speaker 1 of 5
* Marion Dorsch, Blueprint Medicines Corporation, USA
Hedgehog Inhibitors

Thursday, March 25 | 8:00AM - 11:15AM
Targeting Developmental Pathways in Cancer (Joint)
Room: Salon B-C

Speaker 2 of 5
Thomas Thomas Look, Dana-Farber Cancer Institute, USA
Activating Mutations in the ALK Tyrosine Kinase Provide a Therapeutic Target in Neuroblastoma

Thursday, March 25 | 8:00AM - 11:15AM
Targeting Developmental Pathways in Cancer (Joint)
Room: Salon B-C

Speaker 3 of 5
Luisa Iruela-Arispe, University of California, Los Angeles, USA
Angiogenesis, Developmental Pathways and Cancer

Thursday, March 25 | 8:00AM - 11:15AM
Targeting Developmental Pathways in Cancer (Joint)
Room: Salon B-C

Speaker 4 of 5
James F. Amatruda, University of Texas Southwestern Medical Center, USA
Short Talk: BMP Signaling in Germ Cell Differentiation and Germ Cell Tumors

Thursday, March 25 | 8:00AM - 11:15AM
Targeting Developmental Pathways in Cancer (Joint)
Room: Salon B-C

Speaker 5 of 5
Leni S. Jacob, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: Assignment of Aberrant Hedgehog and Wnt Pathway Activity to Disease by Genome-Wide RNAi in Cultured Cells

Thursday, March 25 | 9:20AM - 9:40AM
Coffee Break
Room: Prefunction 2


Thursday, March 25 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Thursday, March 25 | 11:15AM - 1:00PM
Poster Setup
Room: Salon A


Thursday, March 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Salon A


Thursday, March 25 | 4:30PM - 5:00PM
Coffee Available
Room: Prefunction 2


Thursday, March 25 | 5:00PM - 7:00PM
Recurrent Gene Fusions as Cancer Therapeutic Targets
Room: Salon B

Speaker 1 of 5
* Levi A. Garraway, Genentech, Inc, USA

Thursday, March 25 | 5:00PM - 7:00PM
Recurrent Gene Fusions as Cancer Therapeutic Targets
Room: Salon B

Speaker 2 of 5
Hiroyuki Mano, University of Tokyo, Japan
Targeting the ALK Fusion Genes in Lung Cancer

Thursday, March 25 | 5:00PM - 7:00PM
Recurrent Gene Fusions as Cancer Therapeutic Targets
Room: Salon B

Speaker 3 of 5
Arul M. Chinnaiyan, University of Michigan, USA
Targeting Gene Fusions in Prostate Cancer

Thursday, March 25 | 5:00PM - 7:00PM
Recurrent Gene Fusions as Cancer Therapeutic Targets
Room: Salon B

Speaker 4 of 5
Yardena Samuels, Weizmann Institute of Science, Israel
Mutational Analysis of the Melanoma Genome

Thursday, March 25 | 5:00PM - 7:00PM
Recurrent Gene Fusions as Cancer Therapeutic Targets
Room: Salon B

Speaker 5 of 5
Yoshihiro Yamashita, University of Tokyo, Japan
Short Talk: Array-based Genomic Resequencing of Acute Myeloid Leukemia

Thursday, March 25 | 5:00PM - 7:00PM
Mechanisms of Signal Integration II - Coordinated Proteolysi
s
This session is from Signaling Pathways

Room: Salon C

Speaker 1 of 5
* Xi He, Harvard Medical School, USA


Thursday, March 25 | 5:00PM - 7:00PM
Mechanisms of Signal Integration II - Coordinated Proteolysi
s
This session is from Signaling Pathways

Room: Salon C

Speaker 2 of 5
Randall T. Moon, University of Washington School of Medicine, USA
Elucidating Wnt/beta-Catenin Signaling Networks by Integrated siRNA, Proteomic, and Small Molecule Screens


Thursday, March 25 | 5:00PM - 7:00PM
Mechanisms of Signal Integration II - Coordinated Proteolysi
s
This session is from Signaling Pathways

Room: Salon C

Speaker 3 of 5
Jin Jiang, University of Texas Southwestern Medical Center, USA
Kinase Regulation of Hedgehog Signaling


Thursday, March 25 | 5:00PM - 7:00PM
Mechanisms of Signal Integration II - Coordinated Proteolysi
s
This session is from Signaling Pathways

Room: Salon C

Speaker 4 of 5
Ying E. Zhang, NCI, National Institutes of Health, USA
Proteolysis in TGF-beta Signaling and Cancer


Thursday, March 25 | 5:00PM - 7:00PM
Mechanisms of Signal Integration II - Coordinated Proteolysi
s
This session is from Signaling Pathways

Room: Salon C

Speaker 5 of 5
Masahiro Narimatsu, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Canada
Short Talk: Smurf Ubiqutin Ligases are Required for Embryo Patterning during Gastrulation


Thursday, March 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Salon A


Thursday, March 25 | 7:30PM - 10:00PM
Poster Session 2
Room: Salon A


Friday, March 26 | 7:00AM - 8:00AM
Breakfast
Room: Palm Court


Friday, March 26 | 8:00AM - 11:00AM
Toward Rational Targeted Combination Therapy
Room: Salon B

Speaker 1 of 6
* Arul M. Chinnaiyan, University of Michigan, USA

Friday, March 26 | 8:00AM - 11:00AM
Toward Rational Targeted Combination Therapy
Room: Salon B

Speaker 2 of 6
Kenneth P. Nephew, Indiana University, USA
DNA Methylation Inhibitors for Chemotherapy Resensitization of Solid Tumors

Friday, March 26 | 8:00AM - 11:00AM
Toward Rational Targeted Combination Therapy
Room: Salon B

Speaker 3 of 6
Paul G. Polakis, Genentech, Inc., USA
Wnt Antagonists in Cancer

Friday, March 26 | 8:00AM - 11:00AM
Toward Rational Targeted Combination Therapy
Room: Salon B

Speaker 4 of 6
Shaomeng Wang, University of Michigan, USA
Current Targeting of Multiple Key Apoptosis Regulators is Required to Efficiently Kill Tumor Cells

Friday, March 26 | 8:00AM - 11:00AM
Toward Rational Targeted Combination Therapy
Room: Salon B

Speaker 5 of 6
Caroline M. Emery, Dana Farber Cancer Institute, USA
Short Talk: Genetic Studies of Resistance to MEK and BRAF Inhibition

Friday, March 26 | 8:00AM - 11:00AM
Toward Rational Targeted Combination Therapy
Room: Salon B

Speaker 6 of 6
Jinyan Du, Dragonfly Therapeutics, USA
Short Talk: Systematic Characterization of Pathway Interactions with ER Signaling in Human Mammary Carcinomas

Friday, March 26 | 8:00AM - 11:00AM
Mechanisms of Integration III - Transcriptional Regulation a
nd/or Epigenetics/Reversible Histone Methylation
This session is from Signaling Pathways

Room: Salon C

Speaker 1 of 7
* Austin Smith, University of Cambridge, UK


Friday, March 26 | 8:00AM - 11:00AM
Mechanisms of Integration III - Transcriptional Regulation a
nd/or Epigenetics/Reversible Histone Methylation
This session is from Signaling Pathways

Room: Salon C

Speaker 2 of 7
Michael D. Taylor, Hospital for Sick Children, Canada
A Role for Histone Lysine Methylation in the Pathogenesis of Pediatric Brain Tumors?


Friday, March 26 | 8:00AM - 11:00AM
Mechanisms of Integration III - Transcriptional Regulation a
nd/or Epigenetics/Reversible Histone Methylation
This session is from Signaling Pathways

Room: Salon C

Speaker 3 of 7
Marion Dorsch, Blueprint Medicines Corporation, USA
Smoothened Antagonists: Anticipating and Treating Resistance


Friday, March 26 | 8:00AM - 11:00AM
Mechanisms of Integration III - Transcriptional Regulation a
nd/or Epigenetics/Reversible Histone Methylation
This session is from Signaling Pathways

Room: Salon C

Speaker 4 of 7
Ken M. Cadigan, University of Michigan, USA
Selection of Wnt Targets and Subsequent Chromatin Modifications


Friday, March 26 | 8:00AM - 11:00AM
Mechanisms of Integration III - Transcriptional Regulation a
nd/or Epigenetics/Reversible Histone Methylation
This session is from Signaling Pathways

Room: Salon C

Speaker 5 of 7
Feng Cong, Novartis Institutes for BioMedical Research, USA
Short Talk: Targeting Wnt Signaling through TNKS Inhibition and Axin Stabilization


Friday, March 26 | 8:00AM - 11:00AM
Mechanisms of Integration III - Transcriptional Regulation a
nd/or Epigenetics/Reversible Histone Methylation
This session is from Signaling Pathways

Room: Salon C

Speaker 6 of 7
Felix Lohmann, Novartis Institutes for BioMedical Research, Switzerland
Short Talk: KMT1E Mediated H3K9 Methylation is Required for the Maintenance of Embryonic Stem Cells by Repressing Trophectoderm Differentiation


Friday, March 26 | 8:00AM - 11:00AM
Mechanisms of Integration III - Transcriptional Regulation a
nd/or Epigenetics/Reversible Histone Methylation
This session is from Signaling Pathways

Room: Salon C

Speaker 7 of 7
Robert Rottapel, Princess Margaret Hospital, Toronto Medical Discovery Tower, Canada
Short Talk: Tankyrase Functions as a Cross-Regulator of Signalling Pathways


Friday, March 26 | 9:20AM - 9:40AM
Coffee Break
Room: Prefunction 2


Friday, March 26 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Friday, March 26 | 4:30PM - 5:00PM
Coffee Available
Room: Prefunction 2


Friday, March 26 | 5:00PM - 7:00PM
Targeting Metabolic Pathways in Cancer
Room: Salon B

Speaker 1 of 5
* Luisa Iruela-Arispe, University of California, Los Angeles, USA

Friday, March 26 | 5:00PM - 7:00PM
Targeting Metabolic Pathways in Cancer
Room: Salon B

Speaker 2 of 5
Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Targeting Cancer Cell Metabolism

Friday, March 26 | 5:00PM - 7:00PM
Targeting Metabolic Pathways in Cancer
Room: Salon B

Speaker 3 of 5
Valeria Fantin, ORIC Pharmaceuticals, USA
Cancer-Associated IDH1 Mutations Produce 2-Hydroyxglutarate

Friday, March 26 | 5:00PM - 7:00PM
Targeting Metabolic Pathways in Cancer
Room: Salon B

Speaker 4 of 5
Patrick S. Ward, Massachusetts General Hospital, USA
Short Talk: The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations is a Neomorphic Enzyme Activity Converting alpha-Ketoglutarate to 2-Hydroxyglutarate

Friday, March 26 | 5:00PM - 7:00PM
Targeting Metabolic Pathways in Cancer
Room: Salon B

Speaker 5 of 5
Amjad Pervez Khan, University of Michigan, USA
Short Talk: Metabolomic Profiling Delineate Polyamines as Biomarkers for Prostate Cancer Progression

Friday, March 26 | 5:00PM - 7:00PM
Stem Cell Fate and Signaling
This session is from Signaling Pathways
Room: Salon C

Speaker 1 of 5
* Morag Park, McGill University, Canada


Friday, March 26 | 5:00PM - 7:00PM
Stem Cell Fate and Signaling
This session is from Signaling Pathways
Room: Salon C

Speaker 2 of 5
Jim Woodgett, Mount Sinai Hospital, Canada
Coordinate Regulation of Multiple Signaling Pathways and Differentiation Processes by Glycogen Synthase Kinase-3


Friday, March 26 | 5:00PM - 7:00PM
Stem Cell Fate and Signaling
This session is from Signaling Pathways
Room: Salon C

Speaker 3 of 5
Austin Smith, University of Cambridge, UK
Intrinsic and Extrinsic Regulation of the Pluripotent Ground State


Friday, March 26 | 5:00PM - 7:00PM
Stem Cell Fate and Signaling
This session is from Signaling Pathways
Room: Salon C

Speaker 4 of 5
Jeffrey L. Wrana, Mount Sinai Hospital, Canada
Cell Fate and Polarity Signals


Friday, March 26 | 5:00PM - 7:00PM
Stem Cell Fate and Signaling
This session is from Signaling Pathways
Room: Salon C

Speaker 5 of 5
Rita Lukacs, Takeda California, USA
Short Talk: Bmi-1 is a Dominant Self-Renewal Gene in the Murine Prostate that Controls both Stem Cell Maintenance and Cancer Initiation


Friday, March 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Salon A


Saturday, March 27 | 7:00AM - 8:00AM
Breakfast
Room: Palm Court


Saturday, March 27 | 8:00AM - 11:00AM
siRNA Therapeutics
Room: Salon B

Speaker 1 of 7
* William R. Sellers, Broad Institute of MIT and Harvard, USA

Saturday, March 27 | 8:00AM - 11:00AM
siRNA Therapeutics
Room: Salon B

Speaker 2 of 7
Daniel G. Anderson, Massachusetts Institute of Technology, USA
Combinatorial Development of Biomaterials and Synthetic siRNA Delivery Systems

Saturday, March 27 | 8:00AM - 11:00AM
siRNA Therapeutics
Room: Salon B

Speaker 3 of 7
Ian MacLachlan, Tekmira Pharmaceuticals Corp., Canada
Therapeutic Silencing of Polo-Like Kinase 1 and Kinesin Spindle Protein via the Confirmed Mechanism of RNA Interference

Saturday, March 27 | 8:00AM - 11:00AM
siRNA Therapeutics
Room: Salon B

Speaker 4 of 7
John J. Rossi, Beckman Research Institute of the City of Hope, USA
Strategies for RNA Interference (RNAi) Applications in Cancer Therapy

Saturday, March 27 | 8:00AM - 11:00AM
siRNA Therapeutics
Room: Salon B

Speaker 5 of 7
Eric Marcusson, Providence Therapeutics, USA
Short Talk: microRNA Mimics as Cancer Therapeutics

Saturday, March 27 | 8:00AM - 11:00AM
siRNA Therapeutics
Room: Salon B

Speaker 6 of 7
Steven Blake, University of North Carolina at Chapel Hill, USA
Short Talk: Targeted Delivery of siRNA using PRINT® Particles

Saturday, March 27 | 8:00AM - 11:00AM
siRNA Therapeutics
Room: Salon B

Speaker 7 of 7
Kathy L. Fosnaugh, Aminex Therapeutics, Inc., USA
Short Talk: Development of siRNA Therapeutics for Treatment of Bladder Cancer and Hepatocellular Carcinoma

Saturday, March 27 | 8:00AM - 11:00AM
Integrated Signaling in Tumor/Stromal Interaction
This session is from Signaling Pathways
Room: Salon C
Emerging stories around tumors and stroma feeding each other signals and each changing to reinforce cancer.
Speaker 1 of 6
* Jeffrey L. Wrana, Mount Sinai Hospital, Canada


Saturday, March 27 | 8:00AM - 11:00AM
Integrated Signaling in Tumor/Stromal Interaction
This session is from Signaling Pathways
Room: Salon C
Emerging stories around tumors and stroma feeding each other signals and each changing to reinforce cancer.
Speaker 2 of 6
Morag Park, McGill University, Canada
Breast Tumor Microenvironment: Impact on Tumor Heterogeneity and Outcome


Saturday, March 27 | 8:00AM - 11:00AM
Integrated Signaling in Tumor/Stromal Interaction
This session is from Signaling Pathways
Room: Salon C
Emerging stories around tumors and stroma feeding each other signals and each changing to reinforce cancer.
Speaker 3 of 6
John Condeelis, Albert Einstein College of Medicine, USA
The Tumor Microenvironment Invasion Signature: Effects on Tumor Cell Plasticity in vivo


Saturday, March 27 | 8:00AM - 11:00AM
Integrated Signaling in Tumor/Stromal Interaction
This session is from Signaling Pathways
Room: Salon C
Emerging stories around tumors and stroma feeding each other signals and each changing to reinforce cancer.
Speaker 4 of 6
Christine Dierks-Ventling, Friedrich Miescher Institut, Switzerland
Hedgehog Signaling in Hematologic Malignancies


Saturday, March 27 | 8:00AM - 11:00AM
Integrated Signaling in Tumor/Stromal Interaction
This session is from Signaling Pathways
Room: Salon C
Emerging stories around tumors and stroma feeding each other signals and each changing to reinforce cancer.
Speaker 5 of 6
Minoti Apte, University of New South Wales, Australia
Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells


Saturday, March 27 | 8:00AM - 11:00AM
Integrated Signaling in Tumor/Stromal Interaction
This session is from Signaling Pathways
Room: Salon C
Emerging stories around tumors and stroma feeding each other signals and each changing to reinforce cancer.
Speaker 6 of 6
Gabri Van der Pluijm, Leiden University Medical Center, Netherlands
Short Talk: TGFbeta-BMP7 Interactions in Bone Metastasis; Potential Therapeutic Implications


Saturday, March 27 | 9:20AM - 9:40AM
Coffee Break
Room: Prefunction 2


Saturday, March 27 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Saturday, March 27 | 4:30PM - 5:00PM
Coffee Available
Room: Prefunction 2


Saturday, March 27 | 5:00PM - 7:00PM
Novel Biologic and Virus Based Cancer Therapeutics
Room: Salon B

Speaker 1 of 6
* William R. Sellers, Broad Institute of MIT and Harvard, USA

Saturday, March 27 | 5:00PM - 7:00PM
Novel Biologic and Virus Based Cancer Therapeutics
Room: Salon B

Speaker 2 of 6
Serge Muyldermans, Vrije Universiteit Brussel, Belgium
Camelid Nanobodies for Cancer and Diagnostic Assay Development

Saturday, March 27 | 5:00PM - 7:00PM
Novel Biologic and Virus Based Cancer Therapeutics
Room: Salon B

Speaker 3 of 6
Patrick A. Baeuerle, Amgen Research (Munich) GmbH, Germany
Engaging T Cells for Cancer Therapy by Bispecific Antibodies

Saturday, March 27 | 5:00PM - 7:00PM
Novel Biologic and Virus Based Cancer Therapeutics
Room: Salon B

Speaker 4 of 6
Sunjoo Jeong, Dankook University, South Korea
Short Talk: RNA Aptamers for the Modulation of Wnt/beta-catenin Signaling

Saturday, March 27 | 5:00PM - 7:00PM
Novel Biologic and Virus Based Cancer Therapeutics
Room: Salon B

Speaker 5 of 6
Mohammad Qadir, BC Cancer Agency, Canada
Short Talk:

Saturday, March 27 | 5:00PM - 7:00PM
Novel Biologic and Virus Based Cancer Therapeutics
Room: Salon B

Speaker 6 of 6
Sandra E. Dunn, University of British Columbia, Canada
Short Talk:

Saturday, March 27 | 5:00PM - 7:00PM
Aberrant Signal Interactions and Disease
This session is from Signaling Pathways
Room: Salon C

Speaker 1 of 5
* Jim Woodgett, Mount Sinai Hospital, Canada


Saturday, March 27 | 5:00PM - 7:00PM
Aberrant Signal Interactions and Disease
This session is from Signaling Pathways
Room: Salon C

Speaker 2 of 5
Geraldine Weinmaster, David Geffen School of Medicine at UCLA, USA
Ligand Endocytosis and Force Generation in Activation of Notch Signaling


Saturday, March 27 | 5:00PM - 7:00PM
Aberrant Signal Interactions and Disease
This session is from Signaling Pathways
Room: Salon C

Speaker 3 of 5
Bruce A. Edgar, German Cancer Research Center, Germany
Signaling and Stem Cell Control in the Drosophila Intestine


Saturday, March 27 | 5:00PM - 7:00PM
Aberrant Signal Interactions and Disease
This session is from Signaling Pathways
Room: Salon C

Speaker 4 of 5
Adolfo Ferrando, Columbia University, USA
NOTCH1 Transcriptional Networks in Human Leukemia


Saturday, March 27 | 5:00PM - 7:00PM
Aberrant Signal Interactions and Disease
This session is from Signaling Pathways
Room: Salon C

Speaker 5 of 5
Daniela F. Quail, McGill University, Canada
Short Talk: Nodal Promotes Metastasis and Stem Cell Phenotypes in Breast Cancer


Saturday, March 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Palm Court


Saturday, March 27 | 8:00PM - 11:00PM
Entertainment
Room: Palm Court


Saturday, March 27 | 8:00PM - 11:00PM
Cash Bar
Room: Palm Court


Sunday, March 28 | 10:25AM - 10:25AM
Departure


*Session Chair.