Web Desc
Integration of Developmental Signaling Pathways
joint with New Paradigms in Cancer Therapeutics
Organizer(s): Jim Woodgett and Joseph Kelleher
Date: March 23 - 28, 2010
Location: Fairmont Empress Victoria / Victoria Conference Centre, Victoria, BC, Canada
Supported by The Directors' Fund
Summary of Meeting:
While the importance of developmental signaling pathways such as Wnt, Notch, TGFb, Hedgehog, Hippo, etc., in controlling cell fate determination, tissue organization/homeostasis, and their frequent abrogation in disease has been realized over the past few years, the molecular processes by which these pathways conspire combinatorially and temporally to build sophisticated cellular outcomes is only now becoming apparent. Moreover, simplistic approaches that selectively interfere with one pathway in isolation have resulted in unpredicted outcomes and revealed the presence of interdependencies that require consideration of contextual interactions. Therefore, effective therapeutic manipulation of these systems will require understanding of the mechanisms and interdependencies that determine complex physiology. This is emerging from diverse areas of biology and so requires a meeting of different minds to assimilate the findings. This symposium will bring together experts addressing the interactive mechanisms of developmental signaling with the aim of promoting better models of networks and the design of more effective therapeutic strategies.
Scholarship Deadline: November 24 2009
Discounted Abstract Deadline: November 24 2009
Abstract Deadline: December 29 2009
Discounted Registration Deadline: January 25 2010
We gratefully acknowledge the generous grant for this conference provided by:

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Grant No. 1R13HD063246-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, March 23 | 3:00PM - 7:30PM
Registration
Room: Prefunction 2


Tuesday, March 23 | 6:30PM - 7:30PM
Refreshments
Room: Prefunction 2


Tuesday, March 23 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: Salon B-C

Speaker 1 of 1
Hans C. Clevers, Hubrecht Institute, Netherlands
Wnt, Lgr5 Stem Cells and Cancer

Wednesday, March 24 | 7:00AM - 8:00AM
Breakfast
Room: Palm Court


Wednesday, March 24 | 8:00AM - 11:15AM
Integrating Signal Gradients in Development
Room: Salon C
Hh vs. Wnt or TGFbeta, Notch, etc. in developing Neural Tube, Fly Wing Imaginal Disc., A/P or D/V Polarity etc.
Speaker 1 of 6
* Elaine V. Fuchs, Rockefeller University, USA

Wednesday, March 24 | 8:00AM - 11:15AM
Integrating Signal Gradients in Development
Room: Salon C
Hh vs. Wnt or TGFbeta, Notch, etc. in developing Neural Tube, Fly Wing Imaginal Disc., A/P or D/V Polarity etc.
Speaker 2 of 6
Jean-Denis Benazet, University of Southern California, USA
Interlinked Signaling Feedback Loops and Self-Regulation during Mouse Limb Development

Wednesday, March 24 | 8:00AM - 11:15AM
Integrating Signal Gradients in Development
Room: Salon C
Hh vs. Wnt or TGFbeta, Notch, etc. in developing Neural Tube, Fly Wing Imaginal Disc., A/P or D/V Polarity etc.
Speaker 3 of 6
Xi He, Harvard Medical School, USA
Mechanisms of Wnt Signaling and Regulation

Wednesday, March 24 | 8:00AM - 11:15AM
Integrating Signal Gradients in Development
Room: Salon C
Hh vs. Wnt or TGFbeta, Notch, etc. in developing Neural Tube, Fly Wing Imaginal Disc., A/P or D/V Polarity etc.
Speaker 4 of 6
Chi-chung Hui, Hospital for Sick Children, Canada
Regulators of Gli Transcription Factors in Development and Cancer

Wednesday, March 24 | 8:00AM - 11:15AM
Integrating Signal Gradients in Development
Room: Salon C
Hh vs. Wnt or TGFbeta, Notch, etc. in developing Neural Tube, Fly Wing Imaginal Disc., A/P or D/V Polarity etc.
Speaker 5 of 6
Brandon J. Wainwright, University of Queensland, Australia
The Intersection between Hedgehog and Notch Signaling in Development and Cancer

Wednesday, March 24 | 8:00AM - 11:15AM
Integrating Signal Gradients in Development
Room: Salon C
Hh vs. Wnt or TGFbeta, Notch, etc. in developing Neural Tube, Fly Wing Imaginal Disc., A/P or D/V Polarity etc.
Speaker 6 of 6
Elizabeth Ann Grove, University of Chicago, USA
Signaling Gradients in Patterning the Mammalian Cerebral Cortex

Wednesday, March 24 | 8:00AM - 11:15AM
Epigenetic Targets in Cancer
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 1 of 7
* Arul M. Chinnaiyan, University of Michigan, USA


Wednesday, March 24 | 8:00AM - 11:15AM
Epigenetic Targets in Cancer
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 2 of 7
Patrick Trojer, Constellation Pharmaceuticals, USA
Targeting the Dynamics of Histone Lysine Methylation


Wednesday, March 24 | 8:00AM - 11:15AM
Epigenetic Targets in Cancer
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 3 of 7
Thea D. Tlsty, University of California, San Francisco, USA
Reprogramming the Epigenome during Cancer Progression


Wednesday, March 24 | 8:00AM - 11:15AM
Epigenetic Targets in Cancer
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 4 of 7
Peter A. Jones, Van Andel Research Institute, USA
Cancer Epigenomics


Wednesday, March 24 | 8:00AM - 11:15AM
Epigenetic Targets in Cancer
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 5 of 7
Jean-Pierre Issa, Temple University School of Medicine, USA
Combinations Targeting Multiple Epigenetic Pathways


Wednesday, March 24 | 8:00AM - 11:15AM
Epigenetic Targets in Cancer
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 6 of 7
Akihide Yoshimi, Graduate School of Medicine, University of Tokyo, Japan
Short Talk: EVI1 Induces a Novel Epigenetic Regulation of PTEN/AKT/mTOR Signaling through Interaction with Polycomb Complexes in Leukemia


Wednesday, March 24 | 8:00AM - 11:15AM
Epigenetic Targets in Cancer
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 7 of 7
Aliaksei Holik, Cardiff University, UK
Short Talk: Chromatin Remodelling ATPase Brg-1 is an Essential Factor for the Maintenance of the Intestinal Crypt Stem Cell and Wnt Driven Adenoma Formation


Wednesday, March 24 | 9:20AM - 9:40AM
Coffee Break
Room: Prefunction 2


Wednesday, March 24 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Wednesday, March 24 | 11:00AM - 1:00PM
Poster Setup
Room: Salon A


Wednesday, March 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Salon A


Wednesday, March 24 | 4:30PM - 5:00PM
Coffee Available
Room: Prefunction 2


Wednesday, March 24 | 5:00PM - 7:00PM
Mechanisms of Signal Integration I - Hippo Pathway and Cilia
Room: Salon C

Speaker 1 of 5
* Ken M. Cadigan, University of Michigan, USA

Wednesday, March 24 | 5:00PM - 7:00PM
Mechanisms of Signal Integration I - Hippo Pathway and Cilia
Room: Salon C

Speaker 2 of 5
Jeremy F. Reiter, University of California, San Francisco, USA
Primary Cilia Transduce Hedgehog Signals in Both Development and Cancer

Wednesday, March 24 | 5:00PM - 7:00PM
Mechanisms of Signal Integration I - Hippo Pathway and Cilia
Room: Salon C

Speaker 3 of 5
Elaine V. Fuchs, Rockefeller University, USA
Developmental Signaling Pathways in the Skin

Wednesday, March 24 | 5:00PM - 7:00PM
Mechanisms of Signal Integration I - Hippo Pathway and Cilia
Room: Salon C

Speaker 4 of 5
Helen McNeill, Lunenfeld-Tanenbaum Research Institute, Canada
Fat Cadherins in the Regulation of Growth and Planar Cell Polarity

Wednesday, March 24 | 5:00PM - 7:00PM
Mechanisms of Signal Integration I - Hippo Pathway and Cilia
Room: Salon C

Speaker 5 of 5
Rhonda Hui Ping Kan, Institute for Molecular Bioscience, Australia
Short Talk: N-myc and C-myc are Functionally Redundant in Mediating the Effects of Ptch1 Mutation in Epidermis

Wednesday, March 24 | 5:00PM - 7:00PM
Predictive Signatures for Cancer
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 1 of 4
Levi A. Garraway, Genentech, Inc, USA
High-Throughput Oncogene Mutation Profiling in Human Cancer


Wednesday, March 24 | 5:00PM - 7:00PM
Predictive Signatures for Cancer
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 2 of 4
Joe W. Gray, Oregon Health and Science University, USA
Omics Based Approaches to Predict Cancer Therapy


Wednesday, March 24 | 5:00PM - 7:00PM
Predictive Signatures for Cancer
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 3 of 4
William R. Sellers, Broad Institute of MIT and Harvard, USA
Connecting Patients to Therapy: Functional and Comparative Approaches to Translational Oncology


Wednesday, March 24 | 5:00PM - 7:00PM
Predictive Signatures for Cancer
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 4 of 4
Daniel R. Rhodes, University of Michigan, USA
Short Talk: Somatic Mutations in Human Cancer Cell Lines Predict Sorafenib Response


Wednesday, March 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Salon A


Wednesday, March 24 | 7:30PM - 10:00PM
Poster Session 1
Room: Salon A


Thursday, March 25 | 7:00AM - 8:00AM
Breakfast
Room: Palm Court


Thursday, March 25 | 8:00AM - 11:15AM
Targeting Developmental Pathways in Cancer (Joint)
Room: Salon B-C

Speaker 1 of 5
* Marion Dorsch, Blueprint Medicines Corporation, USA
Hedgehog Inhibitors

Thursday, March 25 | 8:00AM - 11:15AM
Targeting Developmental Pathways in Cancer (Joint)
Room: Salon B-C

Speaker 2 of 5
Thomas Thomas Look, Dana-Farber Cancer Institute, USA
Activating Mutations in the ALK Tyrosine Kinase Provide a Therapeutic Target in Neuroblastoma

Thursday, March 25 | 8:00AM - 11:15AM
Targeting Developmental Pathways in Cancer (Joint)
Room: Salon B-C

Speaker 3 of 5
Luisa Iruela-Arispe, University of California, Los Angeles, USA
Angiogenesis, Developmental Pathways and Cancer

Thursday, March 25 | 8:00AM - 11:15AM
Targeting Developmental Pathways in Cancer (Joint)
Room: Salon B-C

Speaker 4 of 5
James F. Amatruda, University of Texas Southwestern Medical Center, USA
Short Talk: BMP Signaling in Germ Cell Differentiation and Germ Cell Tumors

Thursday, March 25 | 8:00AM - 11:15AM
Targeting Developmental Pathways in Cancer (Joint)
Room: Salon B-C

Speaker 5 of 5
Leni S. Jacob, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: Assignment of Aberrant Hedgehog and Wnt Pathway Activity to Disease by Genome-Wide RNAi in Cultured Cells

Thursday, March 25 | 9:20AM - 9:40AM
Coffee Break
Room: Prefunction 2


Thursday, March 25 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Thursday, March 25 | 11:15AM - 1:00PM
Poster Setup
Room: Salon A


Thursday, March 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Salon A


Thursday, March 25 | 4:30PM - 5:00PM
Coffee Available
Room: Prefunction 2


Thursday, March 25 | 5:00PM - 7:00PM
Mechanisms of Signal Integration II - Coordinated Proteolysi
s

Room: Salon C

Speaker 1 of 5
* Xi He, Harvard Medical School, USA

Thursday, March 25 | 5:00PM - 7:00PM
Mechanisms of Signal Integration II - Coordinated Proteolysi
s

Room: Salon C

Speaker 2 of 5
Randall T. Moon, University of Washington School of Medicine, USA
Elucidating Wnt/beta-Catenin Signaling Networks by Integrated siRNA, Proteomic, and Small Molecule Screens

Thursday, March 25 | 5:00PM - 7:00PM
Mechanisms of Signal Integration II - Coordinated Proteolysi
s

Room: Salon C

Speaker 3 of 5
Jin Jiang, University of Texas Southwestern Medical Center, USA
Kinase Regulation of Hedgehog Signaling

Thursday, March 25 | 5:00PM - 7:00PM
Mechanisms of Signal Integration II - Coordinated Proteolysi
s

Room: Salon C

Speaker 4 of 5
Ying E. Zhang, NCI, National Institutes of Health, USA
Proteolysis in TGF-beta Signaling and Cancer

Thursday, March 25 | 5:00PM - 7:00PM
Mechanisms of Signal Integration II - Coordinated Proteolysi
s

Room: Salon C

Speaker 5 of 5
Masahiro Narimatsu, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Canada
Short Talk: Smurf Ubiqutin Ligases are Required for Embryo Patterning during Gastrulation

Thursday, March 25 | 5:00PM - 7:00PM
Recurrent Gene Fusions as Cancer Therapeutic Targets
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 1 of 5
* Levi A. Garraway, Genentech, Inc, USA


Thursday, March 25 | 5:00PM - 7:00PM
Recurrent Gene Fusions as Cancer Therapeutic Targets
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 2 of 5
Hiroyuki Mano, University of Tokyo, Japan
Targeting the ALK Fusion Genes in Lung Cancer


Thursday, March 25 | 5:00PM - 7:00PM
Recurrent Gene Fusions as Cancer Therapeutic Targets
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 3 of 5
Arul M. Chinnaiyan, University of Michigan, USA
Targeting Gene Fusions in Prostate Cancer


Thursday, March 25 | 5:00PM - 7:00PM
Recurrent Gene Fusions as Cancer Therapeutic Targets
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 4 of 5
Yardena Samuels, Weizmann Institute of Science, Israel
Mutational Analysis of the Melanoma Genome


Thursday, March 25 | 5:00PM - 7:00PM
Recurrent Gene Fusions as Cancer Therapeutic Targets
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 5 of 5
Yoshihiro Yamashita, University of Tokyo, Japan
Short Talk: Array-based Genomic Resequencing of Acute Myeloid Leukemia


Thursday, March 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Salon A


Thursday, March 25 | 7:30PM - 10:00PM
Poster Session 2
Room: Salon A


Friday, March 26 | 7:00AM - 8:00AM
Breakfast
Room: Palm Court


Friday, March 26 | 8:00AM - 11:00AM
Mechanisms of Integration III - Transcriptional Regulation a
nd/or Epigenetics/Reversible Histone Methylation

Room: Salon C

Speaker 1 of 7
* Austin Smith, University of Cambridge, UK

Friday, March 26 | 8:00AM - 11:00AM
Mechanisms of Integration III - Transcriptional Regulation a
nd/or Epigenetics/Reversible Histone Methylation

Room: Salon C

Speaker 2 of 7
Michael D. Taylor, Hospital for Sick Children, Canada
A Role for Histone Lysine Methylation in the Pathogenesis of Pediatric Brain Tumors?

Friday, March 26 | 8:00AM - 11:00AM
Mechanisms of Integration III - Transcriptional Regulation a
nd/or Epigenetics/Reversible Histone Methylation

Room: Salon C

Speaker 3 of 7
Marion Dorsch, Blueprint Medicines Corporation, USA
Smoothened Antagonists: Anticipating and Treating Resistance

Friday, March 26 | 8:00AM - 11:00AM
Mechanisms of Integration III - Transcriptional Regulation a
nd/or Epigenetics/Reversible Histone Methylation

Room: Salon C

Speaker 4 of 7
Ken M. Cadigan, University of Michigan, USA
Selection of Wnt Targets and Subsequent Chromatin Modifications

Friday, March 26 | 8:00AM - 11:00AM
Mechanisms of Integration III - Transcriptional Regulation a
nd/or Epigenetics/Reversible Histone Methylation

Room: Salon C

Speaker 5 of 7
Feng Cong, Novartis Institutes for BioMedical Research, USA
Short Talk: Targeting Wnt Signaling through TNKS Inhibition and Axin Stabilization

Friday, March 26 | 8:00AM - 11:00AM
Mechanisms of Integration III - Transcriptional Regulation a
nd/or Epigenetics/Reversible Histone Methylation

Room: Salon C

Speaker 6 of 7
Felix Lohmann, Novartis Institutes for BioMedical Research, Switzerland
Short Talk: KMT1E Mediated H3K9 Methylation is Required for the Maintenance of Embryonic Stem Cells by Repressing Trophectoderm Differentiation

Friday, March 26 | 8:00AM - 11:00AM
Mechanisms of Integration III - Transcriptional Regulation a
nd/or Epigenetics/Reversible Histone Methylation

Room: Salon C

Speaker 7 of 7
Robert Rottapel, Princess Margaret Hospital, Toronto Medical Discovery Tower, Canada
Short Talk: Tankyrase Functions as a Cross-Regulator of Signalling Pathways

Friday, March 26 | 8:00AM - 11:00AM
Toward Rational Targeted Combination Therapy
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 1 of 6
* Arul M. Chinnaiyan, University of Michigan, USA


Friday, March 26 | 8:00AM - 11:00AM
Toward Rational Targeted Combination Therapy
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 2 of 6
Kenneth P. Nephew, Indiana University, USA
DNA Methylation Inhibitors for Chemotherapy Resensitization of Solid Tumors


Friday, March 26 | 8:00AM - 11:00AM
Toward Rational Targeted Combination Therapy
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 3 of 6
Paul G. Polakis, Genentech, Inc., USA
Wnt Antagonists in Cancer


Friday, March 26 | 8:00AM - 11:00AM
Toward Rational Targeted Combination Therapy
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 4 of 6
Shaomeng Wang, University of Michigan, USA
Current Targeting of Multiple Key Apoptosis Regulators is Required to Efficiently Kill Tumor Cells


Friday, March 26 | 8:00AM - 11:00AM
Toward Rational Targeted Combination Therapy
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 5 of 6
Caroline M. Emery, Dana Farber Cancer Institute, USA
Short Talk: Genetic Studies of Resistance to MEK and BRAF Inhibition


Friday, March 26 | 8:00AM - 11:00AM
Toward Rational Targeted Combination Therapy
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 6 of 6
Jinyan Du, Dragonfly Therapeutics, USA
Short Talk: Systematic Characterization of Pathway Interactions with ER Signaling in Human Mammary Carcinomas


Friday, March 26 | 9:20AM - 9:40AM
Coffee Break
Room: Prefunction 2


Friday, March 26 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Friday, March 26 | 4:30PM - 5:00PM
Coffee Available
Room: Prefunction 2


Friday, March 26 | 5:00PM - 7:00PM
Stem Cell Fate and Signaling
Room: Salon C

Speaker 1 of 5
* Morag Park, McGill University, Canada

Friday, March 26 | 5:00PM - 7:00PM
Stem Cell Fate and Signaling
Room: Salon C

Speaker 2 of 5
Jim Woodgett, Mount Sinai Hospital, Canada
Coordinate Regulation of Multiple Signaling Pathways and Differentiation Processes by Glycogen Synthase Kinase-3

Friday, March 26 | 5:00PM - 7:00PM
Stem Cell Fate and Signaling
Room: Salon C

Speaker 3 of 5
Austin Smith, University of Cambridge, UK
Intrinsic and Extrinsic Regulation of the Pluripotent Ground State

Friday, March 26 | 5:00PM - 7:00PM
Stem Cell Fate and Signaling
Room: Salon C

Speaker 4 of 5
Jeffrey L. Wrana, Mount Sinai Hospital, Canada
Cell Fate and Polarity Signals

Friday, March 26 | 5:00PM - 7:00PM
Stem Cell Fate and Signaling
Room: Salon C

Speaker 5 of 5
Rita Lukacs, Takeda California, USA
Short Talk: Bmi-1 is a Dominant Self-Renewal Gene in the Murine Prostate that Controls both Stem Cell Maintenance and Cancer Initiation

Friday, March 26 | 5:00PM - 7:00PM
Targeting Metabolic Pathways in Cancer
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 1 of 5
* Luisa Iruela-Arispe, University of California, Los Angeles, USA


Friday, March 26 | 5:00PM - 7:00PM
Targeting Metabolic Pathways in Cancer
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 2 of 5
Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Targeting Cancer Cell Metabolism


Friday, March 26 | 5:00PM - 7:00PM
Targeting Metabolic Pathways in Cancer
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 3 of 5
Valeria Fantin, ORIC Pharmaceuticals, USA
Cancer-Associated IDH1 Mutations Produce 2-Hydroyxglutarate


Friday, March 26 | 5:00PM - 7:00PM
Targeting Metabolic Pathways in Cancer
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 4 of 5
Patrick S. Ward, Massachusetts General Hospital, USA
Short Talk: The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations is a Neomorphic Enzyme Activity Converting alpha-Ketoglutarate to 2-Hydroxyglutarate


Friday, March 26 | 5:00PM - 7:00PM
Targeting Metabolic Pathways in Cancer
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 5 of 5
Amjad Pervez Khan, University of Michigan, USA
Short Talk: Metabolomic Profiling Delineate Polyamines as Biomarkers for Prostate Cancer Progression


Friday, March 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Salon A


Saturday, March 27 | 7:00AM - 8:00AM
Breakfast
Room: Palm Court


Saturday, March 27 | 8:00AM - 11:00AM
Integrated Signaling in Tumor/Stromal Interaction
Room: Salon C
Emerging stories around tumors and stroma feeding each other signals and each changing to reinforce cancer.
Speaker 1 of 6
* Jeffrey L. Wrana, Mount Sinai Hospital, Canada

Saturday, March 27 | 8:00AM - 11:00AM
Integrated Signaling in Tumor/Stromal Interaction
Room: Salon C
Emerging stories around tumors and stroma feeding each other signals and each changing to reinforce cancer.
Speaker 2 of 6
Morag Park, McGill University, Canada
Breast Tumor Microenvironment: Impact on Tumor Heterogeneity and Outcome

Saturday, March 27 | 8:00AM - 11:00AM
Integrated Signaling in Tumor/Stromal Interaction
Room: Salon C
Emerging stories around tumors and stroma feeding each other signals and each changing to reinforce cancer.
Speaker 3 of 6
John Condeelis, Albert Einstein College of Medicine, USA
The Tumor Microenvironment Invasion Signature: Effects on Tumor Cell Plasticity in vivo

Saturday, March 27 | 8:00AM - 11:00AM
Integrated Signaling in Tumor/Stromal Interaction
Room: Salon C
Emerging stories around tumors and stroma feeding each other signals and each changing to reinforce cancer.
Speaker 4 of 6
Christine Dierks-Ventling, Friedrich Miescher Institut, Switzerland
Hedgehog Signaling in Hematologic Malignancies

Saturday, March 27 | 8:00AM - 11:00AM
Integrated Signaling in Tumor/Stromal Interaction
Room: Salon C
Emerging stories around tumors and stroma feeding each other signals and each changing to reinforce cancer.
Speaker 5 of 6
Minoti Apte, University of New South Wales, Australia
Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells

Saturday, March 27 | 8:00AM - 11:00AM
Integrated Signaling in Tumor/Stromal Interaction
Room: Salon C
Emerging stories around tumors and stroma feeding each other signals and each changing to reinforce cancer.
Speaker 6 of 6
Gabri Van der Pluijm, Leiden University Medical Center, Netherlands
Short Talk: TGFbeta-BMP7 Interactions in Bone Metastasis; Potential Therapeutic Implications

Saturday, March 27 | 8:00AM - 11:00AM
siRNA Therapeutics
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 1 of 7
* William R. Sellers, Broad Institute of MIT and Harvard, USA


Saturday, March 27 | 8:00AM - 11:00AM
siRNA Therapeutics
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 2 of 7
Daniel G. Anderson, Massachusetts Institute of Technology, USA
Combinatorial Development of Biomaterials and Synthetic siRNA Delivery Systems


Saturday, March 27 | 8:00AM - 11:00AM
siRNA Therapeutics
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 3 of 7
Ian MacLachlan, Tekmira Pharmaceuticals Corp., Canada
Therapeutic Silencing of Polo-Like Kinase 1 and Kinesin Spindle Protein via the Confirmed Mechanism of RNA Interference


Saturday, March 27 | 8:00AM - 11:00AM
siRNA Therapeutics
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 4 of 7
John J. Rossi, Beckman Research Institute of the City of Hope, USA
Strategies for RNA Interference (RNAi) Applications in Cancer Therapy


Saturday, March 27 | 8:00AM - 11:00AM
siRNA Therapeutics
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 5 of 7
Eric Marcusson, Providence Therapeutics, USA
Short Talk: microRNA Mimics as Cancer Therapeutics


Saturday, March 27 | 8:00AM - 11:00AM
siRNA Therapeutics
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 6 of 7
Steven Blake, University of North Carolina at Chapel Hill, USA
Short Talk: Targeted Delivery of siRNA using PRINT® Particles


Saturday, March 27 | 8:00AM - 11:00AM
siRNA Therapeutics
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 7 of 7
Kathy L. Fosnaugh, Aminex Therapeutics, Inc., USA
Short Talk: Development of siRNA Therapeutics for Treatment of Bladder Cancer and Hepatocellular Carcinoma


Saturday, March 27 | 9:20AM - 9:40AM
Coffee Break
Room: Prefunction 2


Saturday, March 27 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Saturday, March 27 | 4:30PM - 5:00PM
Coffee Available
Room: Prefunction 2


Saturday, March 27 | 5:00PM - 7:00PM
Aberrant Signal Interactions and Disease
Room: Salon C

Speaker 1 of 5
* Jim Woodgett, Mount Sinai Hospital, Canada

Saturday, March 27 | 5:00PM - 7:00PM
Aberrant Signal Interactions and Disease
Room: Salon C

Speaker 2 of 5
Geraldine Weinmaster, David Geffen School of Medicine at UCLA, USA
Ligand Endocytosis and Force Generation in Activation of Notch Signaling

Saturday, March 27 | 5:00PM - 7:00PM
Aberrant Signal Interactions and Disease
Room: Salon C

Speaker 3 of 5
Bruce A. Edgar, German Cancer Research Center, Germany
Signaling and Stem Cell Control in the Drosophila Intestine

Saturday, March 27 | 5:00PM - 7:00PM
Aberrant Signal Interactions and Disease
Room: Salon C

Speaker 4 of 5
Adolfo Ferrando, Columbia University, USA
NOTCH1 Transcriptional Networks in Human Leukemia

Saturday, March 27 | 5:00PM - 7:00PM
Aberrant Signal Interactions and Disease
Room: Salon C

Speaker 5 of 5
Daniela F. Quail, McGill University, Canada
Short Talk: Nodal Promotes Metastasis and Stem Cell Phenotypes in Breast Cancer

Saturday, March 27 | 5:00PM - 7:00PM
Novel Biologic and Virus Based Cancer Therapeutics
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 1 of 6
* William R. Sellers, Broad Institute of MIT and Harvard, USA


Saturday, March 27 | 5:00PM - 7:00PM
Novel Biologic and Virus Based Cancer Therapeutics
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 2 of 6
Serge Muyldermans, Vrije Universiteit Brussel, Belgium
Camelid Nanobodies for Cancer and Diagnostic Assay Development


Saturday, March 27 | 5:00PM - 7:00PM
Novel Biologic and Virus Based Cancer Therapeutics
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 3 of 6
Patrick A. Baeuerle, Amgen Research (Munich) GmbH, Germany
Engaging T Cells for Cancer Therapy by Bispecific Antibodies


Saturday, March 27 | 5:00PM - 7:00PM
Novel Biologic and Virus Based Cancer Therapeutics
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 4 of 6
Sunjoo Jeong, Dankook University, South Korea
Short Talk: RNA Aptamers for the Modulation of Wnt/beta-catenin Signaling


Saturday, March 27 | 5:00PM - 7:00PM
Novel Biologic and Virus Based Cancer Therapeutics
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 5 of 6
Mohammad Qadir, BC Cancer Agency, Canada
Short Talk:


Saturday, March 27 | 5:00PM - 7:00PM
Novel Biologic and Virus Based Cancer Therapeutics
This session is from Novel Cancer Therapeutics
Room: Salon B

Speaker 6 of 6
Sandra E. Dunn, University of British Columbia, Canada
Short Talk:


Saturday, March 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Palm Court


Saturday, March 27 | 8:00PM - 11:00PM
Entertainment
Room: Palm Court


Saturday, March 27 | 8:00PM - 11:00PM
Cash Bar
Room: Palm Court


Sunday, March 28 | 10:25AM - 10:25AM
Departure


*Session Chair.