Web Desc
Diabetes
joint with Islet Biology
Organizer(s): Juleen R. Zierath, Philippe Froguel, Nancy A. Thornberry and Michael P. Czech
Date: April 12 - 17, 2010
Location: Whistler Conference Centre, Whistler, BC, Canada
Sponsored by Eli Lilly and Company and Hoffmann-La Roche, Inc.
Summary of Meeting:
The increased incidence of Type 2 diabetes mellitus is a growing threat to global health. This chronic and progressive metabolic disease is characterized by insulin resistance and beta cell defects, arising from environmental and genetic factors. Multi-disciplinary approaches that capitalize on genetic, genomic and physiological disciplines are required to gain insight into Type 2 diabetes pathogenesis through an increased understanding of the complicated biology that contributes to the development of insulin resistance and beta cell failure. The meeting will focus on latest advancements in our understanding of the molecular pathogenesis of Type 2 diabetes to accelerate the translation of experimental and clinical discoveries to link phenotype to genotype. Particular emphasis will be placed on 1) epigenetics, genetics and pharmacogenomics of metabolic responses, 2) links between pathways linking obesity, inflammation, and insulin resistance and 3) Type 2 diabetes in children and adolescents. A key goal for the meeting will be to facilitate collaborative interactions between basic and clinical scientists focused on prediction, prevention, and treatment of insulin resistance and diabetes.
Scholarship Deadline: December 14 2009
Discounted Abstract Deadline: December 14 2009
Abstract Deadline: January 15 2010
Discounted Registration Deadline: February 12 2010
We gratefully acknowledge additional support for this conference from:
AdipoGen InternationalALPCO DiagnosticsCEDARLANECovX Research LLC (Pfizer)Educational grant from Lilly USA, LLCHoffmann-La Roche, Inc.Landes BioscienceRigel Pharmaceuticals, Inc.Seahorse Bioscience, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Merck & Co., Inc.

Merck Research Laboratories
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13DK084688-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, April 12 | 3:00PM - 7:30PM
Registration
Room: Foyer


Monday, April 12 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Monday, April 12 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 1 of 4
* Juleen R. Zierath, Karolinska Institutet, Sweden

Monday, April 12 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 2 of 4
Victor R. Ambros, University of Massachusetts, USA
MicroRNAs in Model Systems and Human Disease

Monday, April 12 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 3 of 4
* Markus Stoffel, ETH Zürich, Switzerland

Monday, April 12 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 4 of 4
Jennifer A. Lippincott-Schwartz, Howard Hughes Medical Institute - Janelia Farm, USA
Mitochondrial Role in Cell Cycle Control and Autophagy

Tuesday, April 13 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky Ballroom A, Lower Level


Tuesday, April 13 | 8:00AM - 11:15AM
Genetics of Diabetes
Room: Sea to Sky Ballroom C

Speaker 1 of 7
* Simeon Taylor, University of Maryland School of Medicine, USA

Tuesday, April 13 | 8:00AM - 11:15AM
Genetics of Diabetes
Room: Sea to Sky Ballroom C

Speaker 2 of 7
Philippe Froguel, Imperial College of London, UK
Genome Structure and Point DNA Variation: The Power of the Extreme in Diabesity

Tuesday, April 13 | 8:00AM - 11:15AM
Genetics of Diabetes
Room: Sea to Sky Ballroom C

Speaker 3 of 7
Mark I. McCarthy, University of Oxford, UK
Type 2 Diabetes: Susceptibility Variants across the Allele Frequency Spectrum

Tuesday, April 13 | 8:00AM - 11:15AM
Genetics of Diabetes
Room: Sea to Sky Ballroom C

Speaker 4 of 7
Jose C. Florez, Massachusetts General Hospital, USA
Genetic Epidemiology of Type 2 Diabetes and Related Traits in General Populations

Tuesday, April 13 | 8:00AM - 11:15AM
Genetics of Diabetes
Room: Sea to Sky Ballroom C

Speaker 5 of 7
Eric Schadt, Mount Sinai School of Medicine, USA
Multi-Tissue Networks Elucidate Type 2 Diabetes Circuits

Tuesday, April 13 | 8:00AM - 11:15AM
Genetics of Diabetes
Room: Sea to Sky Ballroom C

Speaker 6 of 7
Jussi A. Pihlajamäki, Kuopio University Hospital, Finland
Short Talk: Alternative Splicing is Regulated by Weight Loss and Differs between Fat Depots in Humans

Tuesday, April 13 | 8:00AM - 11:15AM
Genetics of Diabetes
Room: Sea to Sky Ballroom C

Speaker 7 of 7
Jeremy B.M. Jowett, Baker IDI Heart and Diabetes Institute, Australia
Short Talk: Expression Profiling Identifies Biomarkers for Progression to Type 2 Diabetes

Tuesday, April 13 | 8:00AM - 11:00AM
From Stem Cell Development to Transplantation
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 1 of 6
* Catherine Lee May, University of Pennsylvania, USA


Tuesday, April 13 | 8:00AM - 11:00AM
From Stem Cell Development to Transplantation
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 2 of 6
Bernhard J. Hering, University of Minnesota, USA
Islet Transplantation: Today and Tomorrow


Tuesday, April 13 | 8:00AM - 11:00AM
From Stem Cell Development to Transplantation
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 3 of 6
Anne Grapin-Botton, University of Copenhagen, Denmark
Role of Pancreas 3D Architecture in Endocrine Cell Development


Tuesday, April 13 | 8:00AM - 11:00AM
From Stem Cell Development to Transplantation
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 4 of 6
Lori Sussel, University of Colorado Anschutz Medical Campus, USA
Regulation of Pancreatic Islet Cell Fates


Tuesday, April 13 | 8:00AM - 11:00AM
From Stem Cell Development to Transplantation
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 5 of 6
Maike Sander, University of California, San Diego, USA
Control of Cell Fate Choice in the Pancreas


Tuesday, April 13 | 8:00AM - 11:00AM
From Stem Cell Development to Transplantation
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 6 of 6
Dina Fomina-Yadlin, Harvard University, USA
Short Talk: Altering Pancreatic Cell State with Small Molecules


Tuesday, April 13 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, April 13 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, April 13 | 11:15AM - 1:00PM
Poster Setup
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Tuesday, April 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Tuesday, April 13 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, April 13 | 5:00PM - 7:00PM
Cell and Tissue Signaling Mechanisms in Diabetes
Room: Sea to Sky Ballroom C

Speaker 1 of 5
* Adria Giacca, University of Toronto, Canada

Tuesday, April 13 | 5:00PM - 7:00PM
Cell and Tissue Signaling Mechanisms in Diabetes
Room: Sea to Sky Ballroom C

Speaker 2 of 5
Claire C. Bastie, Albert Einstein College of Medicine, USA
Fyn Kinase and LKB1: A Novel Pathway Regulating Lipid Utilization and Energy Expenditure

Tuesday, April 13 | 5:00PM - 7:00PM
Cell and Tissue Signaling Mechanisms in Diabetes
Room: Sea to Sky Ballroom C

Speaker 3 of 5
Robert E. Lewis, University of Nebraska Medical Center, USA
Molecular Scaffolds as Energy Sensors

Tuesday, April 13 | 5:00PM - 7:00PM
Cell and Tissue Signaling Mechanisms in Diabetes
Room: Sea to Sky Ballroom C

Speaker 4 of 5
Bei B. Zhang, Pfizer Inc., USA
Modulation of Glucose, Amino Acid and Lipid Metabolism Pathways with Pharmacological Agents

Tuesday, April 13 | 5:00PM - 7:00PM
Cell and Tissue Signaling Mechanisms in Diabetes
Room: Sea to Sky Ballroom C

Speaker 5 of 5
Philipp Gut, Nestlé Institute of Health Sciences, Switzerland
Short Talk: In vivo Drug Discovery of New Regulators of Glucose Metabolism using Transgenic “Gluconeogenesis Reporter” Zebrafish

Tuesday, April 13 | 5:00PM - 7:00PM
Signaling in Pancreatic B-Cells
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 1 of 5
* Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA


Tuesday, April 13 | 5:00PM - 7:00PM
Signaling in Pancreatic B-Cells
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 2 of 5
Eckhard Lammert, Heinrich-Heine-University / German Diabetes Center, Germany
Role of Blood Vessels in Pancreatic Islet Development and Function


Tuesday, April 13 | 5:00PM - 7:00PM
Signaling in Pancreatic B-Cells
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 3 of 5
Marc Prentki, Montreal Diabetes Research Center, Canada
Beta Cell Metabolic Signaling and Dysfunction in Type 2 Diabetes


Tuesday, April 13 | 5:00PM - 7:00PM
Signaling in Pancreatic B-Cells
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 4 of 5
Ingo B. Leibiger, Karolinska Institutet, Sweden
Insulin Signaling in the Pancreatic Beta Cell


Tuesday, April 13 | 5:00PM - 7:00PM
Signaling in Pancreatic B-Cells
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 5 of 5
Jocelyn E. Manning Fox, University of Alberta, Canada
Short Talk: Small Ubiquitin-Like Modifier 1 (SUMO1) Directly and Acutely Regulates Insulin Exocytosis from Human beta-Cells


Tuesday, April 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Tuesday, April 13 | 7:30PM - 10:00PM
Poster Session 1
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Wednesday, April 14 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky Ballroom A, Lower Level


Wednesday, April 14 | 8:00AM - 11:15AM
Intertissue Communication
Room: Sea to Sky Ballroom C

Speaker 1 of 7
* Jeffrey S. Elmendorf, Indiana University School of Medicine, USA

Wednesday, April 14 | 8:00AM - 11:15AM
Intertissue Communication
Room: Sea to Sky Ballroom C

Speaker 2 of 7
Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
A Novel Pathway in Adipose Tissue and Liver that Regulates Adiposity

Wednesday, April 14 | 8:00AM - 11:15AM
Intertissue Communication
Room: Sea to Sky Ballroom C

Speaker 3 of 7
Kenneth Walsh, University of Virginia School of Medicine, USA
Discovery of Novel Myokines

Wednesday, April 14 | 8:00AM - 11:15AM
Intertissue Communication
Room: Sea to Sky Ballroom C

Speaker 4 of 7
Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Discovery of Novel Adipokines

Wednesday, April 14 | 8:00AM - 11:15AM
Intertissue Communication
Room: Sea to Sky Ballroom C

Speaker 5 of 7
Fatima Bosch, Universitat Autonoma Barcelona, Spain
Gene Therapy and Diabetes

Wednesday, April 14 | 8:00AM - 11:15AM
Intertissue Communication
Room: Sea to Sky Ballroom C

Speaker 6 of 7
Tsu-Shuen Tsao, University of Arizona, USA
Short Talk: Inhibition of Adiponectin Oligomerization under Oxidizing Conditions and Induction of an Oxidizing Redox Environment in Endoplasmic Reticulum of 3T3-L1 Adipocytes Exposed to High Concentrations of Palmitate

Wednesday, April 14 | 8:00AM - 11:15AM
Intertissue Communication
Room: Sea to Sky Ballroom C

Speaker 7 of 7
Marianna Sadagurski, Wayne State University, USA
Short Talk: Inactivation of Foxo1 in Leptin Receptor (LepRb)-Expressing Neurons Reverses Obesity and Diabetes, Caused by Deletion of Insulin Receptor Substrate 2 (Irs2)

Wednesday, April 14 | 8:00AM - 11:00AM
Transcriptional Networks Signaling
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 1 of 6
* Maike Sander, University of California, San Diego, USA


Wednesday, April 14 | 8:00AM - 11:00AM
Transcriptional Networks Signaling
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 2 of 6
Catherine Lee May, University of Pennsylvania, USA
Islet-1 and its Cofactor Ldb1 in the Endocrine Pancreas


Wednesday, April 14 | 8:00AM - 11:00AM
Transcriptional Networks Signaling
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 3 of 6
Markus Stoffel, ETH Zürich, Switzerland
MicroRNA Networks


Wednesday, April 14 | 8:00AM - 11:00AM
Transcriptional Networks Signaling
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 4 of 6
Roland W. Stein, Vanderbilt University Medical Center, USA


Wednesday, April 14 | 8:00AM - 11:00AM
Transcriptional Networks Signaling
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 5 of 6
Alan D. Attie, University of Wisconsin-Madison, USA
Networks of QTLs, mRNAs, and microRNAs in Beta Cell Growth and Function


Wednesday, April 14 | 8:00AM - 11:00AM
Transcriptional Networks Signaling
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 6 of 6
Melissa K. Thomas, Massachusetts General Hospital, USA
Short Talk: TCF7L2 Deficiency Alters Mouse Metabolic and Islet
Cell Functions with Aging


Wednesday, April 14 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, April 14 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, April 14 | 11:15AM - 1:00PM
Poster Setup
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Wednesday, April 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Wednesday, April 14 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, April 14 | 5:00PM - 7:15PM
Molecular Mechanisms in Insulin Secretion and Action (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 1 of 6
* Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA

Wednesday, April 14 | 5:00PM - 7:15PM
Molecular Mechanisms in Insulin Secretion and Action (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 2 of 6
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Insulin Signaling and Insulin Resistance: The Ultimate Systems Biology Problem

Wednesday, April 14 | 5:00PM - 7:15PM
Molecular Mechanisms in Insulin Secretion and Action (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 3 of 6
Per-Olof Berggren, Karolinska Institutet, Sweden
Systems Biology Approach to Study Beta Cell Function and Survival

Wednesday, April 14 | 5:00PM - 7:15PM
Molecular Mechanisms in Insulin Secretion and Action (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 4 of 6
Morris J. Birnbaum, Pfizer Inc., USA
The Role of Akt in the Regulation of Hepatic Metabolism by Insulin

Wednesday, April 14 | 5:00PM - 7:15PM
Molecular Mechanisms in Insulin Secretion and Action (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 5 of 6
Weiping Han, Singapore Bioimaging Consortium, Singapore
Short Talk: Molecular Regulation of Calcium-Dependent Insulin Secretion

Wednesday, April 14 | 5:00PM - 7:15PM
Molecular Mechanisms in Insulin Secretion and Action (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 6 of 6
Jennifer L. Estall, Institut de Recherches Cliniques de Montréal, Canada
Short Talk: PGC-1alpha Negatively Regulates Hepatic FGF21 Expression by Modulating the Heme/Rev-Erbalpha Axis

Wednesday, April 14 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Wednesday, April 14 | 7:30PM - 10:00PM
Poster Session 2
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Thursday, April 15 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky Ballroom A, Lower Level


Thursday, April 15 | 7:00AM - 11:00AM
Poster Setup
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Thursday, April 15 | 8:00AM - 11:15AM
Inflammatory Mechanisms and Insulin Resistance
Room: Sea to Sky Ballroom C

Speaker 1 of 7
* Nancy A. Thornberry, Kallyope, Inc., USA

Thursday, April 15 | 8:00AM - 11:15AM
Inflammatory Mechanisms and Insulin Resistance
Room: Sea to Sky Ballroom C

Speaker 2 of 7
Diane Mathis, Harvard Medical School, USA
Lymphocyte Regulation of Adipose Tissue Inflammation

Thursday, April 15 | 8:00AM - 11:15AM
Inflammatory Mechanisms and Insulin Resistance
Room: Sea to Sky Ballroom C

Speaker 3 of 7
Roger J. Davis, HHMI/University of Massachusetts Medical School, USA
Pathogenesis Mechanisms of the JNK Pathway

Thursday, April 15 | 8:00AM - 11:15AM
Inflammatory Mechanisms and Insulin Resistance
Room: Sea to Sky Ballroom C

Speaker 4 of 7
Rémy G. Burcelin, Institute of Molecular Medicine, France
Intestinal Microflora, Inflammation, and Metabolic Diseases

Thursday, April 15 | 8:00AM - 11:15AM
Inflammatory Mechanisms and Insulin Resistance
Room: Sea to Sky Ballroom C

Speaker 5 of 7
Michael P. Czech, University of Massachusetts Medical School, USA
RNAi-Based Strategies to Address Metabolic Dysfunction

Thursday, April 15 | 8:00AM - 11:15AM
Inflammatory Mechanisms and Insulin Resistance
Room: Sea to Sky Ballroom C

Speaker 6 of 7
Birgitte Lindegaard, Rigshospitalet, Denmark
Short Talk: IL-18 Increases Intramuscular Fat Oxidation by Activating AMPK

Thursday, April 15 | 8:00AM - 11:15AM
Inflammatory Mechanisms and Insulin Resistance
Room: Sea to Sky Ballroom C

Speaker 7 of 7
Heather C. Denroche, University of British Columbia, Canada
Short Talk: Leptin Therapy Reverses Fasting Hyperglycemia and Enhances Insulin Sensitivity in Diabetic Mice, Independent of Hepatic Leptin Signaling

Thursday, April 15 | 8:00AM - 11:15AM
Control of Insulin Secretory Machinery in Diabetes
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 1 of 7
* Per-Olof Berggren, Karolinska Institutet, Sweden


Thursday, April 15 | 8:00AM - 11:15AM
Control of Insulin Secretory Machinery in Diabetes
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 2 of 7
Patrik Rorsman, Oxford Centre for Diabetes, Endocrinology and Metabolism, UK
Calcium Channels and Insulin Exocytosis


Thursday, April 15 | 8:00AM - 11:15AM
Control of Insulin Secretory Machinery in Diabetes
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 3 of 7
Michele Solimena, Dresden University of Technology, Germany
Signaling from the Insulin Granule to the Nucleus


Thursday, April 15 | 8:00AM - 11:15AM
Control of Insulin Secretory Machinery in Diabetes
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 4 of 7
Gerard Karsenty, Columbia University Medical Center, USA
Regulation of Glucose Homeostasis by Osteocalcin


Thursday, April 15 | 8:00AM - 11:15AM
Control of Insulin Secretory Machinery in Diabetes
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 5 of 7
Herbert Y. Gaisano, University of Toronto, Canada
Molecular Mechanism of Insulin Granule-Granule Fusion Contributing to Biphasic Insulin Secretion


Thursday, April 15 | 8:00AM - 11:15AM
Control of Insulin Secretory Machinery in Diabetes
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 6 of 7
Ja Young Kim-Muller, Pfizer Inc, USA
Short Talk: Abnormal Regulation of Basal Insulin Secretion in Mice Homozygous
for a Constitutively Deacetylated FoxO1 Allele


Thursday, April 15 | 8:00AM - 11:15AM
Control of Insulin Secretory Machinery in Diabetes
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 7 of 7
Hail Kim, Korea Advanced Institute of Science and Technology, South Korea
Short Talk: Serotonin Regulates Pancreatic beta-Cell Mass during Pregnancy


Thursday, April 15 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, April 15 | 11:00AM - 5:00PM
Poster Viewing
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Thursday, April 15 | 11:30AM - 12:30PM
Lunch
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Thursday, April 15 | 12:30PM - 2:30PM
Poster Session 3
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Thursday, April 15 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, April 15 | 5:00PM - 7:15PM
Emerging Targets for Improving Insulin Action and Secretion
(Joint)

Room: Sea to Sky Ballroom B,C

Speaker 1 of 6
* C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA

Thursday, April 15 | 5:00PM - 7:15PM
Emerging Targets for Improving Insulin Action and Secretion
(Joint)

Room: Sea to Sky Ballroom B,C

Speaker 2 of 6
Richard D. DiMarchi, Indiana University and Novo Nordisk, USA
Novel Glucagon-Like Chimera Peptides – Virtues of Combinatorial Pharmacology

Thursday, April 15 | 5:00PM - 7:15PM
Emerging Targets for Improving Insulin Action and Secretion
(Joint)

Room: Sea to Sky Ballroom B,C

Speaker 3 of 6
David E. Moller, Eli Lilly and Company, USA
Challenges and Opportunities for Diabetes Drug Discovery

Thursday, April 15 | 5:00PM - 7:15PM
Emerging Targets for Improving Insulin Action and Secretion
(Joint)

Room: Sea to Sky Ballroom B,C

Speaker 4 of 6
Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland
Integrating Metabolic Control by NAD+ Sensors

Thursday, April 15 | 5:00PM - 7:15PM
Emerging Targets for Improving Insulin Action and Secretion
(Joint)

Room: Sea to Sky Ballroom B,C

Speaker 5 of 6
Tian-Qiang Sun, Rigel Pharmaceuticals, Inc., USA
Short Talk: Small Molecule Adiponectin Mimetics Improve Hepatic Steatosis and Insulin Sensitivity in Diabetic Mouse Models

Thursday, April 15 | 5:00PM - 7:15PM
Emerging Targets for Improving Insulin Action and Secretion
(Joint)

Room: Sea to Sky Ballroom B,C

Speaker 6 of 6
Christine Esau, Arcturus Therapeutics, USA
Short Talk: Inhibition of Let-7 with Anti-miR Oligonucleotides Improves Insulin Resistance in DIO Mice

Thursday, April 15 | 7:15PM - 7:15PM
On Own for Dinner


Friday, April 16 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky Ballroom A, Lower Level


Friday, April 16 | 8:00AM - 11:15AM
Insulin Secretion and Action in Humans (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 1 of 7
* Michael P. Czech, University of Massachusetts Medical School, USA

Friday, April 16 | 8:00AM - 11:15AM
Insulin Secretion and Action in Humans (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 2 of 7
Andrew Hattersley, University of Exeter Medical School, UK
Learning from Genetic Beta Cell Defects in Man

Friday, April 16 | 8:00AM - 11:15AM
Insulin Secretion and Action in Humans (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 3 of 7
Anna Moore, Michigan State University, USA
Imaging Pancreatic Islets in vivo: Current Status

Friday, April 16 | 8:00AM - 11:15AM
Insulin Secretion and Action in Humans (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 4 of 7
Juleen R. Zierath, Karolinska Institutet, Sweden
Gene/Environment Influence on Skeletal Muscle Insulin Sensitivity in Type 2 Diabetic Patients

Friday, April 16 | 8:00AM - 11:15AM
Insulin Secretion and Action in Humans (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 5 of 7
Peter Arner, Karolinska Institutet, Sweden
Dysfunction in Human Adipose Tissue and Insulin Resistance



Friday, April 16 | 8:00AM - 11:15AM
Insulin Secretion and Action in Humans (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 6 of 7
Michael Ristow, Swiss Federal Institute of Technology Zurich - ETH, Switzerland
Short Talk: Impaired Insulin Signaling Extends Life Span by Increasing Oxidative Stress

Friday, April 16 | 8:00AM - 11:15AM
Insulin Secretion and Action in Humans (Joint)
Room: Sea to Sky Ballroom B,C

Speaker 7 of 7
Mary Armanios, Johns Hopkins University School of Medicine, USA
Short Talk: Short Telomeres Lead to beta-cell Dysfunction and Impair Glucose Tolerance

Friday, April 16 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, April 16 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Friday, April 16 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Friday, April 16 | 5:00PM - 7:00PM
Type 2 Diabetes in Children and Adolescents
Room: Sea to Sky Ballroom C

Speaker 1 of 5
* Philippe Froguel, Imperial College of London, UK

Friday, April 16 | 5:00PM - 7:00PM
Type 2 Diabetes in Children and Adolescents
Room: Sea to Sky Ballroom C

Speaker 2 of 5
Rebecca Anne Simmons, University of Pennsylvania School of Medicine, USA
Epigenetic Mechanisms in the Development of Type 2 Diabetes

Friday, April 16 | 5:00PM - 7:00PM
Type 2 Diabetes in Children and Adolescents
Room: Sea to Sky Ballroom C

Speaker 3 of 5
Susan Ozanne, University of Cambridge, UK
Early Life Programming of Type 2 Diabetes

Friday, April 16 | 5:00PM - 7:00PM
Type 2 Diabetes in Children and Adolescents
Room: Sea to Sky Ballroom C

Speaker 4 of 5
Phil Zeitler, University of Colorado, Denver, USA
Type 2 Diabetes in Children and Adolescents: Epidemiology, Pathophysiology, and Comorbidities

Friday, April 16 | 5:00PM - 7:00PM
Type 2 Diabetes in Children and Adolescents
Room: Sea to Sky Ballroom C

Speaker 5 of 5
Kasper Rud, University of Copenhagen, Denmark
Short Talk: Effects of Gestational Low Protein Diet Followed by Postnatal High Fat or High Sucrose Diet on the Interplay between Fat and Carbohydrate Metabolism in Rat Mitochondria

Friday, April 16 | 5:00PM - 7:00PM
Beta Cell Stress in Diabetes
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 1 of 5
* Marc Prentki, Montreal Diabetes Research Center, Canada


Friday, April 16 | 5:00PM - 7:00PM
Beta Cell Stress in Diabetes
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 2 of 5
Marc Y. Donath, University Hospital Basel, Switzerland
Islet Inflammation in Type 2 Diabetes: Novel Mechanisms and Treatment


Friday, April 16 | 5:00PM - 7:00PM
Beta Cell Stress in Diabetes
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 3 of 5
Thomas Mandrup-Poulsen, Hagedorn Research Institute, Denmark
Cytokine Signaling in Inflammatory beta-Cell Destruction


Friday, April 16 | 5:00PM - 7:00PM
Beta Cell Stress in Diabetes
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 4 of 5
Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA
Insulin/IGF-I Signaling, Mitochondrial Function and Endoplasmic Stress in Pancreatic beta-Cells


Friday, April 16 | 5:00PM - 7:00PM
Beta Cell Stress in Diabetes
This session is from Islet Biology
Room: Sea to Sky Ballroom B

Speaker 5 of 5
Raghavendra G. Mirmira, Indiana University School of Medicine, USA
Short Talk: The Unique Hypusine Modification of eIF5A Promotes Islet Inflammation and Dysfunction during the Development of Diabetes


Friday, April 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Friday, April 16 | 8:00PM - 11:00PM
Entertainment
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Friday, April 16 | 8:00PM - 11:00PM
Cash Bar
Room: Foyer/Mountain View/Sea to Sky Ballroom A


Saturday, April 17 | 10:25AM - 10:25AM
Departure


*Session Chair.