Web Desc
Frontiers of NMR in Biology
Organizer(s): Michael F. Summers, Dorothee Kern and David E. Wemmer
Date: January 08 - 13, 2011
Location: Big Sky Resort, Big Sky, MT, USA
Supported by the Directors' Fund
Summary of Meeting:
Nuclear magnetic resonance (NMR) spectroscopy is now a well-established tool for determining structures of small to moderate size biomacromolecules. The horizon is expanding, however, through recent methodological advances, including the evolution of approaches that combine NMR with computational, X-ray crystallographic, cryo-electron microscopic, and single molecule methodologies. These have led to unprecedented insights into structure, dynamics, and mechanisms, even in large systems, making NMR a premier tool for studying macromolecular function. This symposium will highlight the latest technological advances in NMR spectroscopy, as well as recent bio-functional discoveries made using these approaches. Emphasis will be placed on systems that challenge the current technology, including high-molecular weights, membrane proteins, folding and dynamics, transient states, and drug discovery. In addition, the symposium will provide a forum for discussions on the needs and efforts to consolidate the best approaches, and on the latest advances and new trends in biological NMR.
Scholarship Deadline: September 15 2010
Discounted Abstract Deadline: September 15 2010
Abstract Deadline: October 12 2010
Discounted Registration Deadline: November 9 2010
We gratefully acknowledge additional support for this conference from:
Agilent TechnologiesBruker BioSpin Corp.Cambridge Isotope LaboratoriesCEDARLANEISOTEC, a member of the Sigma-Aldrich GroupNew Era Enterprises, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM095021-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, January 08 | 3:00PM - 7:30PM
Registration
Room: Lower Atrium


Saturday, January 08 | 6:15PM - 7:15PM
Refreshments
Room: Lower Atrium


Saturday, January 08 | 7:15PM - 9:30PM
Welcome and Keynote Session
Room: Gallatin

Speaker 1 of 3
* Robert Kaptein, University of Utrecht, Netherlands

Saturday, January 08 | 7:15PM - 9:30PM
Welcome and Keynote Session
Room: Gallatin

Speaker 2 of 3
Juli Feigon, University of California, Los Angeles, USA
Structure and Dynamics of Telomerase and Riboswitch RNAs

Saturday, January 08 | 7:15PM - 9:30PM
Welcome and Keynote Session
Room: Gallatin

Speaker 3 of 3
Gerhard Wagner, Harvard Medical School, USA
NMR for Elucidating Molecular Mechanism

Sunday, January 09 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson/Madison


Sunday, January 09 | 8:00AM - 11:00AM
New Methods for Studying Structure and Dynamics I
Room: Gallatin

Speaker 1 of 6
* Erik R. P. Zuiderweg, University of Michigan, USA

Sunday, January 09 | 8:00AM - 11:00AM
New Methods for Studying Structure and Dynamics I
Room: Gallatin

Speaker 2 of 6
Robert G. Griffin, Massachusetts Institute of Technology, USA
Development and Applications of DNP in Solid State NMR

Sunday, January 09 | 8:00AM - 11:00AM
New Methods for Studying Structure and Dynamics I
Room: Gallatin

Speaker 3 of 6
Christopher P. Jaroniec, Ohio State University, USA
Magic Angle Spinning Solid State NMR Structural Studies of Proteins Modified with Paramagnetic Tags

Sunday, January 09 | 8:00AM - 11:00AM
New Methods for Studying Structure and Dynamics I
Room: Gallatin

Speaker 4 of 6
Lewis E. Kay, University of Toronto, Canada
Seeing the Invisible by Solution NMR Spectroscopy

Sunday, January 09 | 8:00AM - 11:00AM
New Methods for Studying Structure and Dynamics I
Room: Gallatin

Speaker 5 of 6
Marcellus Ubbink, Leiden University, Netherlands
Paramagnetic Probes for Studying Macromolecular Structure and Interactions

Sunday, January 09 | 8:00AM - 11:00AM
New Methods for Studying Structure and Dynamics I
Room: Gallatin

Speaker 6 of 6
Kaushik Dutta, New York Structural Biology Center, USA
Short Talk: Molecular Basis for FGF Receptor Autoinhibition by Alternative Splicing of Acid Box Region

Sunday, January 09 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Sunday, January 09 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Sunday, January 09 | 11:00AM - 1:00PM
Poster Setup
Room: Jefferson/Madison


Sunday, January 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Jefferson/Madison


Sunday, January 09 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Sunday, January 09 | 5:00PM - 7:00PM
Exciting New Results
Room: Gallatin

Speaker 1 of 7
* Arthur G. Palmer, III, Columbia University, USA

Sunday, January 09 | 5:00PM - 7:00PM
Exciting New Results
Room: Gallatin

Speaker 2 of 7
Sharon L. Campbell, University of North Carolina at Chapel Hill, USA
Alternative Model of Vinculin/Actin Interactions and Regulation by Phosphorylation

Sunday, January 09 | 5:00PM - 7:00PM
Exciting New Results
Room: Gallatin

Speaker 3 of 7
Gabriele L. Varani, University of Washington, USA
RNA Dynamics in Real Time and Assembly of Ribonucleoproteins

Sunday, January 09 | 5:00PM - 7:00PM
Exciting New Results
Room: Gallatin

Speaker 4 of 7
A. Joshua Wand, University of Pennsylvania, USA
The Dark Energy of Proteins Comes to Light

Sunday, January 09 | 5:00PM - 7:00PM
Exciting New Results
Room: Gallatin

Speaker 5 of 7
Daniel A. Fox, University of Virginia, USA
Poster Preview: NMR Backbone Assignment of Opa I: A Mediator of Host: Neisseria Interactions

Sunday, January 09 | 5:00PM - 7:00PM
Exciting New Results
Room: Gallatin

Speaker 6 of 7
Thomas C. Edrington, University of Virginia, USA
Poster Preview: Solution Structure of the Outer Membrane Protein OprH from Pseudomonas Aeruginosa in Lipid Micelles and Bicelles

Sunday, January 09 | 5:00PM - 7:00PM
Exciting New Results
Room: Gallatin

Speaker 7 of 7
Ranabir Das, National Institutes of Health, USA
Poster Preview: Studies on the Molecular Mechanism of Allosteric Activation in Ubiquitin Conjugating Enzyme Ube2g2

Sunday, January 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson/Madison


Sunday, January 09 | 7:30PM - 10:00PM
Poster Session 1
Room: Jefferson/Madison
Poster Rounds with Distinguished Scientists (by sign-up at check-in)

Monday, January 10 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson/Madison


Monday, January 10 | 8:00AM - 11:00AM
New Insights into RNA Structure and Dynamics
Room: Gallatin

Speaker 1 of 9
* Mark P. Foster, Ohio State University, USA

Monday, January 10 | 8:00AM - 11:00AM
New Insights into RNA Structure and Dynamics
Room: Gallatin

Speaker 2 of 9
Frédéric H.T. Allain, ETH Zurich, Switzerland
Insight into RNA Splicing and Editing Mechanisms from the NMR Structures of Protein-RNA Complexes

Monday, January 10 | 8:00AM - 11:00AM
New Insights into RNA Structure and Dynamics
Room: Gallatin

Speaker 3 of 9
Victoria Manuel D'Souza, Harvard University, USA
Genetic Recoding in Retroviruses: Structure and Function of a Readthrough Pseudoknot

Monday, January 10 | 8:00AM - 11:00AM
New Insights into RNA Structure and Dynamics
Room: Gallatin

Speaker 4 of 9
Arthur G. Palmer, III, Columbia University, USA
Protein Dynamics from Experiment and Simulation and pulse Sequence

Monday, January 10 | 8:00AM - 11:00AM
New Insights into RNA Structure and Dynamics
Room: Gallatin

Speaker 5 of 9
Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA
Structure of the 156 Nucleotide HIV-1 RNA Packaging Signal

Monday, January 10 | 8:00AM - 11:00AM
New Insights into RNA Structure and Dynamics
Room: Gallatin

Speaker 6 of 9
Lili Mao, Center for Advanced Biotechnology and Medicine (CABM), USA
Poster Preview: Specific Amino Acid Labeling of Proteins with High Molecular Weight in E. coli for NMR Studies

Monday, January 10 | 8:00AM - 11:00AM
New Insights into RNA Structure and Dynamics
Room: Gallatin

Speaker 7 of 9
Pétur O. Heidarsson, University of Copenhagen, Denmark
Poster Preview: Insights into the CRISPR Viral Defense System from the Solution Structure and DNA Binding Properties of a Crenarchaeal CRISPR Binding Protein

Monday, January 10 | 8:00AM - 11:00AM
New Insights into RNA Structure and Dynamics
Room: Gallatin

Speaker 8 of 9
Helene M. M. Launay, University of Lille 1, UMR 8576, France
Poster Preview: NMR Studies of the Co-Translational Folding of an Immunoglobulin Domain

Monday, January 10 | 8:00AM - 11:00AM
New Insights into RNA Structure and Dynamics
Room: Gallatin

Speaker 9 of 9
Gaya K. Amarasinghe, Washington University in St. Louis, USA
Poster Preview: Mechanisms of Innate Immune Evasion by the Multifunctional Ebolavirus VP35: Implications for Target Identification and Validation of Panfiloviral Inhibitors

Monday, January 10 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Monday, January 10 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Monday, January 10 | 11:00AM - 1:00PM
Poster Setup
Room: Jefferson/Madison


Monday, January 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Jefferson/Madison


Monday, January 10 | 2:30PM - 4:30PM
Workshop 1: Advances in Protein and RNA Labeling
Room: Gallatin

Speaker 1 of 5
* Blanton S. Tolbert, Case Western Reserve University, USA

Monday, January 10 | 2:30PM - 4:30PM
Workshop 1: Advances in Protein and RNA Labeling
Room: Gallatin

Speaker 2 of 5
Jonathan M. Brown, ProSpect Pharma, Inc., USA
Methods and Materials for Specific Isotope Labeling of Biomolecules

Monday, January 10 | 2:30PM - 4:30PM
Workshop 1: Advances in Protein and RNA Labeling
Room: Gallatin

Speaker 3 of 5
Kwaku Dayie, University of Maryland, USA
Chemo-Enzymatic Selective Labeling Methods to Study RNAs

Monday, January 10 | 2:30PM - 4:30PM
Workshop 1: Advances in Protein and RNA Labeling
Room: Gallatin

Speaker 4 of 5
James R. Williamson, The Scripps Research Institute, USA
Methods for Selective Isotope Labeling of RNA

Monday, January 10 | 2:30PM - 4:30PM
Workshop 1: Advances in Protein and RNA Labeling
Room: Gallatin

Speaker 5 of 5
Bernhard H. Geierstanger, Genomics Institute of the Novartis Research Foundation, USA
Site-Specific Protein Labeling with Unnatural Amino Acids

Monday, January 10 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Monday, January 10 | 5:00PM - 7:00PM
Protein Folding and Function
Room: Gallatin

Speaker 1 of 7
* Jane Dyson, The Scripps Research Institute, USA

Monday, January 10 | 5:00PM - 7:00PM
Protein Folding and Function
Room: Gallatin

Speaker 2 of 7
Peter E. Wright, The Scripps Research Institute, USA
Promiscuous Liaisons: Functional Interactions of Intrinsically Disordered Proteins in Biological Signaling

Monday, January 10 | 5:00PM - 7:00PM
Protein Folding and Function
Room: Gallatin

Speaker 3 of 7
Roberto Nguyen De Guzman, University of Kansas, USA
Structure and Assembly of Bacterial Needles

Monday, January 10 | 5:00PM - 7:00PM
Protein Folding and Function
Room: Gallatin

Speaker 4 of 7
David E. Wemmer, University of California, Berkeley, USA
Conformations of Abeta Peptides/EGFR

Monday, January 10 | 5:00PM - 7:00PM
Protein Folding and Function
Room: Gallatin

Speaker 5 of 7
Peter J. Lukavsky, Central European institute of Technology, Czech Republic
Poster Preview: NMR Structures of RNA Transport Signals Reveal Unexpected A’-Form RNA Helices Required for mRNA Transport in Drosophila

Monday, January 10 | 5:00PM - 7:00PM
Protein Folding and Function
Room: Gallatin

Speaker 6 of 7
Michael A. Massiah, George Washington University, USA
Poster Preview: Human MID1 is a TRIM Protein that Targets PP2A for Ubiquitination: Probing the Structure and Function of MID1 Three Consecutive E3 Ligase Domains

Monday, January 10 | 5:00PM - 7:00PM
Protein Folding and Function
Room: Gallatin

Speaker 7 of 7
Brett M. Kroncke, University of Virginia, USA
Poster Preview: Investigations Toward Improving Solution NMR Paramagnetic Relaxation Enhancement Distance Restraints for MTSSL Labeled alpha-helical Membrane Proteins

Monday, January 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson/Madison


Monday, January 10 | 7:30PM - 10:00PM
Poster Session 2
Room: Jefferson/Madison
Poster Rounds with Distinguished Scientists (by sign-up at check-in)

Tuesday, January 11 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson/Madison


Tuesday, January 11 | 8:00AM - 11:00AM
Interactions at Membranes
Room: Gallatin

Speaker 1 of 9
* Linda Columbus, University of Virginia, USA

Tuesday, January 11 | 8:00AM - 11:00AM
Interactions at Membranes
Room: Gallatin

Speaker 2 of 9
Tatiana G. Kutateladze, University of Colorado School of Medicine, USA
Structural Insights into Histone Code Recognition by PHD Fingers

Tuesday, January 11 | 8:00AM - 11:00AM
Interactions at Membranes
Room: Gallatin

Speaker 3 of 9
Katherine A. Henzler-Wildman, University of Wisconsin-Madison, USA
Mechanistic Studies of Drug Transporter Systems

Tuesday, January 11 | 8:00AM - 11:00AM
Interactions at Membranes
Room: Gallatin

Speaker 4 of 9
Charles R. Sanders, Vanderbilt University School of Medicine, USA
Debutante Ball for Peripheral Myelin Protein 22

Tuesday, January 11 | 8:00AM - 11:00AM
Interactions at Membranes
Room: Gallatin

Speaker 5 of 9
Francesca M. Marassi, Sanford-Burnham Medical Research Institute, USA
Structural Studies of Bacterial Cell Envelope Proteins

Tuesday, January 11 | 8:00AM - 11:00AM
Interactions at Membranes
Room: Gallatin

Speaker 6 of 9
Andreas Schlundt, Goethe University Frankfurt, Germany
Poster Preview: Bidirectional Binding of a Self-Antigen to an MHC Class II Molecule

Tuesday, January 11 | 8:00AM - 11:00AM
Interactions at Membranes
Room: Gallatin

Speaker 7 of 9
Thomas Spirig, University of California, Los Angeles, USA
Poster Preview: Visualizing Transient Protein-Protein Complexes that Transfer Heme Across the Cell Wall of Staphylococcus aureus

Tuesday, January 11 | 8:00AM - 11:00AM
Interactions at Membranes
Room: Gallatin

Speaker 8 of 9
Blanton S. Tolbert, Case Western Reserve University, USA
Poster Preview: Probing the Molecular Determinants of HIV Alternative Splicing Regulation: NMR and Thermodynamic Studies of UP1/ESS3

Tuesday, January 11 | 8:00AM - 11:00AM
Interactions at Membranes
Room: Gallatin

Speaker 9 of 9
Jonathan W. Werner-Allen, Duke University Medical Center, USA
Poster Preview: Application of Sparse Sampling and FFT-CLEAN to 4-D NOESY for Global Fold Calculations of Large Proteins

Tuesday, January 11 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Tuesday, January 11 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Tuesday, January 11 | 11:00AM - 1:00PM
Poster Setup
Room: Jefferson/Madison


Tuesday, January 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Jefferson/Madison


Tuesday, January 11 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Tuesday, January 11 | 5:00PM - 7:00PM
Drug Targets
Room: Gallatin

Speaker 1 of 7
* Melissa A. Starovasnik, Genentech, Inc., USA

Tuesday, January 11 | 5:00PM - 7:00PM
Drug Targets
Room: Gallatin

Speaker 2 of 7
David J. Weber, University of Maryland, USA
S100 Protein Dynamics and Implications for Drug Design

Tuesday, January 11 | 5:00PM - 7:00PM
Drug Targets
Room: Gallatin

Speaker 3 of 7
Wolfgang Peti, University of Arizona, USA
Structural Biology of Large Intracellular Signaling Complexes

Tuesday, January 11 | 5:00PM - 7:00PM
Drug Targets
Room: Gallatin

Speaker 4 of 7
Alessio Ciulli, University of Dundee, School of Life Sciences, UK
Fragment-based Approaches to Chemically Interrogate Drug Targets: NMR and Other Methods

Tuesday, January 11 | 5:00PM - 7:00PM
Drug Targets
Room: Gallatin

Speaker 5 of 7
Casey O'Connor, Medical College of Wisconsin, USA
Poster Preview: Dynamics and Ligand Binding in Ras

Tuesday, January 11 | 5:00PM - 7:00PM
Drug Targets
Room: Gallatin

Speaker 6 of 7
Gabriela C. Pérez-Alvarado, Iowa State University, USA
Poster Preview: Structural Determinants of Molecular Recognition by the Adaptor Protein LMO7

Tuesday, January 11 | 5:00PM - 7:00PM
Drug Targets
Room: Gallatin

Speaker 7 of 7
Yonggang Chang, University of California, Merced, USA
Poster Preview: Timekeeping Mechanism of a Circadian Oscillator

Tuesday, January 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson/Madison


Tuesday, January 11 | 7:30PM - 10:00PM
Poster Session 3
Room: Jefferson/Madison
Poster Rounds with Distinguished Scientists (by sign-up at check-in)

Wednesday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson/Madison


Wednesday, January 12 | 8:00AM - 11:00AM
Macromolecular Interactions
Room: Gallatin

Speaker 1 of 6
* Valerie Copié, Montana State University, USA

Wednesday, January 12 | 8:00AM - 11:00AM
Macromolecular Interactions
Room: Gallatin

Speaker 2 of 6
Kurt Wüthrich, ETH Zürich, Switzerland
Conformational Polymorphism in Cellular Prion Proteins and Transmissible Spongiform Encephalopathies

Wednesday, January 12 | 8:00AM - 11:00AM
Macromolecular Interactions
Room: Gallatin

Speaker 3 of 6
Kylie J. Walters, NCI, National Institutes of Health, USA
Mechanistic Insights into Ubiquitin-Dependent Proteolysis

Wednesday, January 12 | 8:00AM - 11:00AM
Macromolecular Interactions
Room: Gallatin

Speaker 4 of 6
Tatyana I. Igumenova, Texas A&M University, USA
Structure and Dynamics of Lipid-Binding Modules of PKCalpha by NMR

Wednesday, January 12 | 8:00AM - 11:00AM
Macromolecular Interactions
Room: Gallatin

Speaker 5 of 6
Mitsu Ikura, University of Toronto, Canada
Probing Cancer Cell Signaling by NMR: Structure, Interaction, and Kinetics of the Small GTPase Cycle

Wednesday, January 12 | 8:00AM - 11:00AM
Macromolecular Interactions
Room: Gallatin

Speaker 6 of 6
G. Marius Clore, NIDDK, National Institutes of Health, USA
Short Talk: Solution Structure of the 128 kDa Enzyme I Dimer from Escherichia coli and its 146 kDa Complex With HPr Using Residual Dipolar Couplings and Small and Wide Angle X-Ray Scattering

Wednesday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Wednesday, January 12 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Wednesday, January 12 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Wednesday, January 12 | 5:00PM - 7:00PM
New Methods for Studying Structure and Dynamics II
Room: Gallatin

Speaker 1 of 5
* R. Andrew Byrd, NCI, National Institutes of Health, USA

Wednesday, January 12 | 5:00PM - 7:00PM
New Methods for Studying Structure and Dynamics II
Room: Gallatin

Speaker 2 of 5
Marc Baldus, Utrecht University, Netherlands
Solid-State NMR on Complex Biomolecules

Wednesday, January 12 | 5:00PM - 7:00PM
New Methods for Studying Structure and Dynamics II
Room: Gallatin

Speaker 3 of 5
Dorothee Kern, Brandeis University, HHMI, USA
View at the Summit – Transition States in a Kinase

Wednesday, January 12 | 5:00PM - 7:00PM
New Methods for Studying Structure and Dynamics II
Room: Gallatin

Speaker 4 of 5
Yun-Xing Wang, NCI, National Institutes of Health, USA
Short Talk: A New Approach to Structure Determination of RNAs in Solution

Wednesday, January 12 | 5:00PM - 7:00PM
New Methods for Studying Structure and Dynamics II
Room: Gallatin

Speaker 5 of 5
Ad Bax, NIDDK, National Institutes of Health, USA
Chemical Shifts, Dipolar Couplings and SAXS: How Can They Help?

Wednesday, January 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson/Madison


Wednesday, January 12 | 8:00PM - 11:00PM
Entertainment
Room: Jefferson/Madison


Wednesday, January 12 | 8:00PM - 11:00PM
Cash Bar
Room: Jefferson/Madison


Thursday, January 13 | 10:25AM - 10:25AM
Departure


*Session Chair.