Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Frontiers of NMR in Life Sciences (2017C5)
Frontiers of NMR in Biology (2013A3)

Web Desc
Frontiers of NMR in Biology Organizer(s): Michael F. Summers, Dorothee Kern and David E. Wemmer Date: January 08 - 13, 2011 Location: Big Sky Resort, Big Sky, MT, USA Supported by the Directors' Fund Summary of Meeting: Nuclear magnetic resonance (NMR) spectroscopy is now a well-established tool for determining structures of small to moderate size biomacromolecules. The horizon is expanding, however, through recent methodological advances, including the evolution of approaches that combine NMR with computational, X-ray crystallographic, cryo-electron microscopic, and single molecule methodologies. These have led to unprecedented insights into structure, dynamics, and mechanisms, even in large systems, making NMR a premier tool for studying macromolecular function. This symposium will highlight the latest technological advances in NMR spectroscopy, as well as recent bio-functional discoveries made using these approaches. Emphasis will be placed on systems that challenge the current technology, including high-molecular weights, membrane proteins, folding and dynamics, transient states, and drug discovery. In addition, the symposium will provide a forum for discussions on the needs and efforts to consolidate the best approaches, and on the latest advances and new trends in biological NMR. Scholarship Deadline: September 15 2010 Discounted Abstract Deadline: September 15 2010 Abstract Deadline: October 12 2010 Discounted Registration Deadline: November 9 2010 We gratefully acknowledge additional support for this conference from: We gratefully acknowledge the generous grant for this conference provided by: National Institute of General Medical Sciences (NIGMS) Grant No. 1R13GM095021-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Frontiers of NMR in Biology

Organizer(s): Michael F. Summers, Dorothee Kern and David E. Wemmer

Date: January 08 - 13, 2011
Location: Big Sky Resort, Big Sky, MT, USA

Supported by the Directors' Fund

Summary of Meeting:

Nuclear magnetic resonance (NMR) spectroscopy is now a well-established tool for determining structures of small to moderate size biomacromolecules. The horizon is expanding, however, through recent methodological advances, including the evolution of approaches that combine NMR with computational, X-ray crystallographic, cryo-electron microscopic, and single molecule methodologies. These have led to unprecedented insights into structure, dynamics, and mechanisms, even in large systems, making NMR a premier tool for studying macromolecular function. This symposium will highlight the latest technological advances in NMR spectroscopy, as well as recent bio-functional discoveries made using these approaches. Emphasis will be placed on systems that challenge the current technology, including high-molecular weights, membrane proteins, folding and dynamics, transient states, and drug discovery. In addition, the symposium will provide a forum for discussions on the needs and efforts to consolidate the best approaches, and on the latest advances and new trends in biological NMR.

Scholarship Deadline: September 15 2010

Discounted Abstract Deadline: September 15 2010

Abstract Deadline: October 12 2010

Discounted Registration Deadline: November 9 2010

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM095021-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Saturday, January 08 \| 3:00PM - 7:30PM Registration Room: Lower Atrium
Saturday, January 08 \| 6:15PM - 7:15PM Refreshments Room: Lower Atrium
Saturday, January 08 \| 7:15PM - 9:30PM Welcome and Keynote Session Room: Gallatin Speaker 1 of 3 * Robert Kaptein, University of Utrecht, Netherlands
Saturday, January 08 \| 7:15PM - 9:30PM Welcome and Keynote Session Room: Gallatin Speaker 2 of 3 Juli Feigon, University of California, Los Angeles, USA Structure and Dynamics of Telomerase and Riboswitch RNAs
Saturday, January 08 \| 7:15PM - 9:30PM Welcome and Keynote Session Room: Gallatin Speaker 3 of 3 Gerhard Wagner, Harvard Medical School, USA NMR for Elucidating Molecular Mechanism
Sunday, January 09 \| 7:00AM - 8:00AM Breakfast Room: Jefferson/Madison
Sunday, January 09 \| 8:00AM - 11:00AM New Methods for Studying Structure and Dynamics I Room: Gallatin Speaker 1 of 6 * Erik R. P. Zuiderweg, University of Michigan, USA
Sunday, January 09 \| 8:00AM - 11:00AM New Methods for Studying Structure and Dynamics I Room: Gallatin Speaker 2 of 6 Robert G. Griffin, Massachusetts Institute of Technology, USA Development and Applications of DNP in Solid State NMR
Sunday, January 09 \| 8:00AM - 11:00AM New Methods for Studying Structure and Dynamics I Room: Gallatin Speaker 3 of 6 Christopher P. Jaroniec, Ohio State University, USA Magic Angle Spinning Solid State NMR Structural Studies of Proteins Modified with Paramagnetic Tags
Sunday, January 09 \| 8:00AM - 11:00AM New Methods for Studying Structure and Dynamics I Room: Gallatin Speaker 4 of 6 Lewis E. Kay, University of Toronto, Canada Seeing the Invisible by Solution NMR Spectroscopy
Sunday, January 09 \| 8:00AM - 11:00AM New Methods for Studying Structure and Dynamics I Room: Gallatin Speaker 5 of 6 Marcellus Ubbink, Leiden University, Netherlands Paramagnetic Probes for Studying Macromolecular Structure and Interactions
Sunday, January 09 \| 8:00AM - 11:00AM New Methods for Studying Structure and Dynamics I Room: Gallatin Speaker 6 of 6 Kaushik Dutta, New York Structural Biology Center, USA Short Talk: Molecular Basis for FGF Receptor Autoinhibition by Alternative Splicing of Acid Box Region
Sunday, January 09 \| 9:20AM - 9:40AM Coffee Break Room: Lower Atrium
Sunday, January 09 \| 10:00AM - 10:00AM On Own for Lunch and Recreation
Sunday, January 09 \| 11:00AM - 1:00PM Poster Setup Room: Jefferson/Madison
Sunday, January 09 \| 1:00PM - 10:00PM Poster Viewing Room: Jefferson/Madison
Sunday, January 09 \| 4:30PM - 5:00PM Coffee Available Room: Lower Atrium
Sunday, January 09 \| 5:00PM - 7:00PM Exciting New Results Room: Gallatin Speaker 1 of 7 * Arthur G. Palmer, III, Columbia University, USA
Sunday, January 09 \| 5:00PM - 7:00PM Exciting New Results Room: Gallatin Speaker 2 of 7 Sharon L. Campbell, University of North Carolina at Chapel Hill, USA Alternative Model of Vinculin/Actin Interactions and Regulation by Phosphorylation
Sunday, January 09 \| 5:00PM - 7:00PM Exciting New Results Room: Gallatin Speaker 3 of 7 Gabriele L. Varani, University of Washington, USA RNA Dynamics in Real Time and Assembly of Ribonucleoproteins
Sunday, January 09 \| 5:00PM - 7:00PM Exciting New Results Room: Gallatin Speaker 4 of 7 A. Joshua Wand, University of Pennsylvania, USA The Dark Energy of Proteins Comes to Light
Sunday, January 09 \| 5:00PM - 7:00PM Exciting New Results Room: Gallatin Speaker 5 of 7 Daniel A. Fox, University of Virginia, USA Poster Preview: NMR Backbone Assignment of Opa I: A Mediator of Host: Neisseria Interactions
Sunday, January 09 \| 5:00PM - 7:00PM Exciting New Results Room: Gallatin Speaker 6 of 7 Thomas C. Edrington, University of Virginia, USA Poster Preview: Solution Structure of the Outer Membrane Protein OprH from Pseudomonas Aeruginosa in Lipid Micelles and Bicelles
Sunday, January 09 \| 5:00PM - 7:00PM Exciting New Results Room: Gallatin Speaker 7 of 7 Ranabir Das, National Institutes of Health, USA Poster Preview: Studies on the Molecular Mechanism of Allosteric Activation in Ubiquitin Conjugating Enzyme Ube2g2
Sunday, January 09 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Jefferson/Madison
Sunday, January 09 \| 7:30PM - 10:00PM Poster Session 1 Room: Jefferson/Madison Poster Rounds with Distinguished Scientists (by sign-up at check-in)
Monday, January 10 \| 7:00AM - 8:00AM Breakfast Room: Jefferson/Madison
Monday, January 10 \| 8:00AM - 11:00AM New Insights into RNA Structure and Dynamics Room: Gallatin Speaker 1 of 9 * Mark P. Foster, Ohio State University, USA
Monday, January 10 \| 8:00AM - 11:00AM New Insights into RNA Structure and Dynamics Room: Gallatin Speaker 2 of 9 Frédéric H.T. Allain, ETH Zurich, Switzerland Insight into RNA Splicing and Editing Mechanisms from the NMR Structures of Protein-RNA Complexes
Monday, January 10 \| 8:00AM - 11:00AM New Insights into RNA Structure and Dynamics Room: Gallatin Speaker 3 of 9 Victoria Manuel D'Souza, Harvard University, USA Genetic Recoding in Retroviruses: Structure and Function of a Readthrough Pseudoknot
Monday, January 10 \| 8:00AM - 11:00AM New Insights into RNA Structure and Dynamics Room: Gallatin Speaker 4 of 9 Arthur G. Palmer, III, Columbia University, USA Protein Dynamics from Experiment and Simulation and pulse Sequence
Monday, January 10 \| 8:00AM - 11:00AM New Insights into RNA Structure and Dynamics Room: Gallatin Speaker 5 of 9 Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA Structure of the 156 Nucleotide HIV-1 RNA Packaging Signal
Monday, January 10 \| 8:00AM - 11:00AM New Insights into RNA Structure and Dynamics Room: Gallatin Speaker 6 of 9 Lili Mao, Center for Advanced Biotechnology and Medicine (CABM), USA Poster Preview: Specific Amino Acid Labeling of Proteins with High Molecular Weight in E. coli for NMR Studies
Monday, January 10 \| 8:00AM - 11:00AM New Insights into RNA Structure and Dynamics Room: Gallatin Speaker 7 of 9 Pétur O. Heidarsson, University of Copenhagen, Denmark Poster Preview: Insights into the CRISPR Viral Defense System from the Solution Structure and DNA Binding Properties of a Crenarchaeal CRISPR Binding Protein
Monday, January 10 \| 8:00AM - 11:00AM New Insights into RNA Structure and Dynamics Room: Gallatin Speaker 8 of 9 Helene M. M. Launay, University of Lille 1, UMR 8576, France Poster Preview: NMR Studies of the Co-Translational Folding of an Immunoglobulin Domain
Monday, January 10 \| 8:00AM - 11:00AM New Insights into RNA Structure and Dynamics Room: Gallatin Speaker 9 of 9 Gaya K. Amarasinghe, Washington University in St. Louis, USA Poster Preview: Mechanisms of Innate Immune Evasion by the Multifunctional Ebolavirus VP35: Implications for Target Identification and Validation of Panfiloviral Inhibitors
Monday, January 10 \| 9:20AM - 9:40AM Coffee Break Room: Lower Atrium
Monday, January 10 \| 10:00AM - 10:00AM On Own for Lunch and Recreation
Monday, January 10 \| 11:00AM - 1:00PM Poster Setup Room: Jefferson/Madison
Monday, January 10 \| 1:00PM - 10:00PM Poster Viewing Room: Jefferson/Madison
Monday, January 10 \| 2:30PM - 4:30PM Workshop 1: Advances in Protein and RNA Labeling Room: Gallatin Speaker 1 of 5 * Blanton S. Tolbert, Case Western Reserve University, USA
Monday, January 10 \| 2:30PM - 4:30PM Workshop 1: Advances in Protein and RNA Labeling Room: Gallatin Speaker 2 of 5 Jonathan M. Brown, ProSpect Pharma, Inc., USA Methods and Materials for Specific Isotope Labeling of Biomolecules
Monday, January 10 \| 2:30PM - 4:30PM Workshop 1: Advances in Protein and RNA Labeling Room: Gallatin Speaker 3 of 5 Kwaku Dayie, University of Maryland, USA Chemo-Enzymatic Selective Labeling Methods to Study RNAs
Monday, January 10 \| 2:30PM - 4:30PM Workshop 1: Advances in Protein and RNA Labeling Room: Gallatin Speaker 4 of 5 James R. Williamson, The Scripps Research Institute, USA Methods for Selective Isotope Labeling of RNA
Monday, January 10 \| 2:30PM - 4:30PM Workshop 1: Advances in Protein and RNA Labeling Room: Gallatin Speaker 5 of 5 Bernhard H. Geierstanger, Genomics Institute of the Novartis Research Foundation, USA Site-Specific Protein Labeling with Unnatural Amino Acids
Monday, January 10 \| 4:30PM - 5:00PM Coffee Available Room: Lower Atrium
Monday, January 10 \| 5:00PM - 7:00PM Protein Folding and Function Room: Gallatin Speaker 1 of 7 * Jane Dyson, The Scripps Research Institute, USA
Monday, January 10 \| 5:00PM - 7:00PM Protein Folding and Function Room: Gallatin Speaker 2 of 7 Peter E. Wright, The Scripps Research Institute, USA Promiscuous Liaisons: Functional Interactions of Intrinsically Disordered Proteins in Biological Signaling
Monday, January 10 \| 5:00PM - 7:00PM Protein Folding and Function Room: Gallatin Speaker 3 of 7 Roberto Nguyen De Guzman, University of Kansas, USA Structure and Assembly of Bacterial Needles
Monday, January 10 \| 5:00PM - 7:00PM Protein Folding and Function Room: Gallatin Speaker 4 of 7 David E. Wemmer, University of California, Berkeley, USA Conformations of Abeta Peptides/EGFR
Monday, January 10 \| 5:00PM - 7:00PM Protein Folding and Function Room: Gallatin Speaker 5 of 7 Peter J. Lukavsky, Central European institute of Technology, Czech Republic Poster Preview: NMR Structures of RNA Transport Signals Reveal Unexpected A’-Form RNA Helices Required for mRNA Transport in Drosophila
Monday, January 10 \| 5:00PM - 7:00PM Protein Folding and Function Room: Gallatin Speaker 6 of 7 Michael A. Massiah, George Washington University, USA Poster Preview: Human MID1 is a TRIM Protein that Targets PP2A for Ubiquitination: Probing the Structure and Function of MID1 Three Consecutive E3 Ligase Domains
Monday, January 10 \| 5:00PM - 7:00PM Protein Folding and Function Room: Gallatin Speaker 7 of 7 Brett M. Kroncke, University of Virginia, USA Poster Preview: Investigations Toward Improving Solution NMR Paramagnetic Relaxation Enhancement Distance Restraints for MTSSL Labeled alpha-helical Membrane Proteins
Monday, January 10 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Jefferson/Madison
Monday, January 10 \| 7:30PM - 10:00PM Poster Session 2 Room: Jefferson/Madison Poster Rounds with Distinguished Scientists (by sign-up at check-in)
Tuesday, January 11 \| 7:00AM - 8:00AM Breakfast Room: Jefferson/Madison
Tuesday, January 11 \| 8:00AM - 11:00AM Interactions at Membranes Room: Gallatin Speaker 1 of 9 * Linda Columbus, University of Virginia, USA
Tuesday, January 11 \| 8:00AM - 11:00AM Interactions at Membranes Room: Gallatin Speaker 2 of 9 Tatiana G. Kutateladze, University of Colorado School of Medicine, USA Structural Insights into Histone Code Recognition by PHD Fingers
Tuesday, January 11 \| 8:00AM - 11:00AM Interactions at Membranes Room: Gallatin Speaker 3 of 9 Katherine A. Henzler-Wildman, University of Wisconsin-Madison, USA Mechanistic Studies of Drug Transporter Systems
Tuesday, January 11 \| 8:00AM - 11:00AM Interactions at Membranes Room: Gallatin Speaker 4 of 9 Charles R. Sanders, Vanderbilt University School of Medicine, USA Debutante Ball for Peripheral Myelin Protein 22
Tuesday, January 11 \| 8:00AM - 11:00AM Interactions at Membranes Room: Gallatin Speaker 5 of 9 Francesca M. Marassi, Sanford-Burnham Medical Research Institute, USA Structural Studies of Bacterial Cell Envelope Proteins
Tuesday, January 11 \| 8:00AM - 11:00AM Interactions at Membranes Room: Gallatin Speaker 6 of 9 Andreas Schlundt, Goethe University Frankfurt, Germany Poster Preview: Bidirectional Binding of a Self-Antigen to an MHC Class II Molecule
Tuesday, January 11 \| 8:00AM - 11:00AM Interactions at Membranes Room: Gallatin Speaker 7 of 9 Thomas Spirig, University of California, Los Angeles, USA Poster Preview: Visualizing Transient Protein-Protein Complexes that Transfer Heme Across the Cell Wall of Staphylococcus aureus
Tuesday, January 11 \| 8:00AM - 11:00AM Interactions at Membranes Room: Gallatin Speaker 8 of 9 Blanton S. Tolbert, Case Western Reserve University, USA Poster Preview: Probing the Molecular Determinants of HIV Alternative Splicing Regulation: NMR and Thermodynamic Studies of UP1/ESS3
Tuesday, January 11 \| 8:00AM - 11:00AM Interactions at Membranes Room: Gallatin Speaker 9 of 9 Jonathan W. Werner-Allen, Duke University Medical Center, USA Poster Preview: Application of Sparse Sampling and FFT-CLEAN to 4-D NOESY for Global Fold Calculations of Large Proteins
Tuesday, January 11 \| 9:20AM - 9:40AM Coffee Break Room: Lower Atrium
Tuesday, January 11 \| 10:00AM - 10:00AM On Own for Lunch and Recreation
Tuesday, January 11 \| 11:00AM - 1:00PM Poster Setup Room: Jefferson/Madison
Tuesday, January 11 \| 1:00PM - 10:00PM Poster Viewing Room: Jefferson/Madison
Tuesday, January 11 \| 4:30PM - 5:00PM Coffee Available Room: Lower Atrium
Tuesday, January 11 \| 5:00PM - 7:00PM Drug Targets Room: Gallatin Speaker 1 of 7 * Melissa A. Starovasnik, Genentech, Inc., USA
Tuesday, January 11 \| 5:00PM - 7:00PM Drug Targets Room: Gallatin Speaker 2 of 7 David J. Weber, University of Maryland, USA S100 Protein Dynamics and Implications for Drug Design
Tuesday, January 11 \| 5:00PM - 7:00PM Drug Targets Room: Gallatin Speaker 3 of 7 Wolfgang Peti, University of Arizona, USA Structural Biology of Large Intracellular Signaling Complexes
Tuesday, January 11 \| 5:00PM - 7:00PM Drug Targets Room: Gallatin Speaker 4 of 7 Alessio Ciulli, University of Dundee, School of Life Sciences, UK Fragment-based Approaches to Chemically Interrogate Drug Targets: NMR and Other Methods
Tuesday, January 11 \| 5:00PM - 7:00PM Drug Targets Room: Gallatin Speaker 5 of 7 Casey O'Connor, Medical College of Wisconsin, USA Poster Preview: Dynamics and Ligand Binding in Ras
Tuesday, January 11 \| 5:00PM - 7:00PM Drug Targets Room: Gallatin Speaker 6 of 7 Gabriela C. Pérez-Alvarado, Iowa State University, USA Poster Preview: Structural Determinants of Molecular Recognition by the Adaptor Protein LMO7
Tuesday, January 11 \| 5:00PM - 7:00PM Drug Targets Room: Gallatin Speaker 7 of 7 Yonggang Chang, University of California, Merced, USA Poster Preview: Timekeeping Mechanism of a Circadian Oscillator
Tuesday, January 11 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Jefferson/Madison
Tuesday, January 11 \| 7:30PM - 10:00PM Poster Session 3 Room: Jefferson/Madison Poster Rounds with Distinguished Scientists (by sign-up at check-in)
Wednesday, January 12 \| 7:00AM - 8:00AM Breakfast Room: Jefferson/Madison
Wednesday, January 12 \| 8:00AM - 11:00AM Macromolecular Interactions Room: Gallatin Speaker 1 of 6 * Valerie Copié, Montana State University, USA
Wednesday, January 12 \| 8:00AM - 11:00AM Macromolecular Interactions Room: Gallatin Speaker 2 of 6 Kurt Wüthrich, ETH Zürich, Switzerland Conformational Polymorphism in Cellular Prion Proteins and Transmissible Spongiform Encephalopathies
Wednesday, January 12 \| 8:00AM - 11:00AM Macromolecular Interactions Room: Gallatin Speaker 3 of 6 Kylie J. Walters, NCI, National Institutes of Health, USA Mechanistic Insights into Ubiquitin-Dependent Proteolysis
Wednesday, January 12 \| 8:00AM - 11:00AM Macromolecular Interactions Room: Gallatin Speaker 4 of 6 Tatyana I. Igumenova, Texas A&M University, USA Structure and Dynamics of Lipid-Binding Modules of PKCalpha by NMR
Wednesday, January 12 \| 8:00AM - 11:00AM Macromolecular Interactions Room: Gallatin Speaker 5 of 6 Mitsu Ikura, University of Toronto, Canada Probing Cancer Cell Signaling by NMR: Structure, Interaction, and Kinetics of the Small GTPase Cycle
Wednesday, January 12 \| 8:00AM - 11:00AM Macromolecular Interactions Room: Gallatin Speaker 6 of 6 G. Marius Clore, NIDDK, National Institutes of Health, USA Short Talk: Solution Structure of the 128 kDa Enzyme I Dimer from Escherichia coli and its 146 kDa Complex With HPr Using Residual Dipolar Couplings and Small and Wide Angle X-Ray Scattering
Wednesday, January 12 \| 9:20AM - 9:40AM Coffee Break Room: Lower Atrium
Wednesday, January 12 \| 10:00AM - 10:00AM On Own for Lunch and Recreation
Wednesday, January 12 \| 4:30PM - 5:00PM Coffee Available Room: Lower Atrium
Wednesday, January 12 \| 5:00PM - 7:00PM New Methods for Studying Structure and Dynamics II Room: Gallatin Speaker 1 of 5 * R. Andrew Byrd, NCI, National Institutes of Health, USA
Wednesday, January 12 \| 5:00PM - 7:00PM New Methods for Studying Structure and Dynamics II Room: Gallatin Speaker 2 of 5 Marc Baldus, Utrecht University, Netherlands Solid-State NMR on Complex Biomolecules
Wednesday, January 12 \| 5:00PM - 7:00PM New Methods for Studying Structure and Dynamics II Room: Gallatin Speaker 3 of 5 Dorothee Kern, Brandeis University, HHMI, USA View at the Summit – Transition States in a Kinase
Wednesday, January 12 \| 5:00PM - 7:00PM New Methods for Studying Structure and Dynamics II Room: Gallatin Speaker 4 of 5 Yun-Xing Wang, NCI, National Institutes of Health, USA Short Talk: A New Approach to Structure Determination of RNAs in Solution
Wednesday, January 12 \| 5:00PM - 7:00PM New Methods for Studying Structure and Dynamics II Room: Gallatin Speaker 5 of 5 Ad Bax, NIDDK, National Institutes of Health, USA Chemical Shifts, Dipolar Couplings and SAXS: How Can They Help?
Wednesday, January 12 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Jefferson/Madison
Wednesday, January 12 \| 8:00PM - 11:00PM Entertainment Room: Jefferson/Madison
Wednesday, January 12 \| 8:00PM - 11:00PM Cash Bar Room: Jefferson/Madison
Thursday, January 13 \| 10:25AM - 10:25AM Departure *Session Chair.