Web Desc
NK and NKT Cell Biology: Specificity and Redundancy of Innate Responses
Organizer(s): James P. Di Santo, Eleanor M. Riley and Mitchell Kronenberg
Date: January 09 - 14, 2011
Location: Beaver Run Resort, Breckenridge, CO, USA
Supported by the Directors' Fund
Summary of Meeting:
Our knowledge base in innate immunity has exploded over the past decade, and our understanding of innate immune mechanisms will soon impact in the clinics. Nevertheless, we still have much to learn about how NK cells and NKT cells shape innate and adaptive immune responses. This meeting will address issues related to the biological roles of these two specialized innate lymphocyte populations by bringing together NK and NKT cell experts to discuss their latest cutting-edge results on topics including NK/NKT development, NK/NKT cell ligand recognition, NK/NKT activation and “crosstalk”, and roles for NK/NKT cells as both effectors and regulators of the immune response in inflammatory disease, infection and cancer. This ‘confrontation’ between NK cell and NKT cell biologists should promote a lively forum for discussion and debate about the specificity and redundancy of NK/NKT cell responses, and can hopefully lead to new collaborations to help advance our understanding of the biological roles of these important innate mediators.
Scholarship Deadline: September 15 2010
Discounted Abstract Deadline: September 15 2010
Abstract Deadline: October 12 2010
Discounted Registration Deadline: November 9 2010
We gratefully acknowledge additional support for this conference from:
STEMCELL Technologies, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI091292-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 09 | 3:00PM - 7:30PM
Registration
Room: Foyer


Sunday, January 09 | 6:15PM - 7:15PM
Refreshments
Room: Foyer


Sunday, January 09 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Peaks 4-5

Speaker 1 of 1
Jürg Tschopp, University of Lausanne, Switzerland
The Inflammasome in Health and Disease

Monday, January 10 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Monday, January 10 | 8:00AM - 11:15AM
Development of NK and NKT Cells
Room: Peaks 4-5

Speaker 1 of 6
Hugh J.M. Brady, Imperial College London, UK
E4bp4 in NK Cell development

Monday, January 10 | 8:00AM - 11:15AM
Development of NK and NKT Cells
Room: Peaks 4-5

Speaker 2 of 6
Molly Thomas, University of California, San Francisco, USA
Short Talk: Eri1 Modulates Small RNAs in Lymphocytes and is Required for Natural Killer Cell Homeostasis

Monday, January 10 | 8:00AM - 11:15AM
Development of NK and NKT Cells
Room: Peaks 4-5

Speaker 3 of 6
Cheong-Hee Chang, University of Michigan, USA
Unique Properties of Innate CD4 T Cells Selected by Thymocytes

Monday, January 10 | 8:00AM - 11:15AM
Development of NK and NKT Cells
Room: Peaks 4-5

Speaker 4 of 6
* Derek B. Sant'Angelo, Robert Wood Johnson Medical School, USA
The Transcription Factor PLZF Controls the Development of Mouse and Human Innate T Cells

Monday, January 10 | 8:00AM - 11:15AM
Development of NK and NKT Cells
Room: Peaks 4-5

Speaker 5 of 6
Louise M. D'Cruz, University of Pittsburgh, USA
Short Talk: E and Id Proteins in Development and Homeostasis of iNKT Cells

Monday, January 10 | 8:00AM - 11:15AM
Development of NK and NKT Cells
Room: Peaks 4-5

Speaker 6 of 6
Maria do Carmo Leite-de-Moraes, CNRS, University Paris 5, France
iNKT17

Monday, January 10 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Monday, January 10 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Monday, January 10 | 11:15AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Monday, January 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Monday, January 10 | 2:30PM - 4:30PM
Workshop 1: Recognition by NK/NKT Receptors
Room: Peaks 4-5

Speaker 1 of 7
* Mitchell Kronenberg, La Jolla Institute for Allergy and Immunology, USA

Monday, January 10 | 2:30PM - 4:30PM
Workshop 1: Recognition by NK/NKT Receptors
Room: Peaks 4-5

Speaker 2 of 7
* Laurent Gapin, University of Colorado and National Jewish Medical and Research Center, USA
The Crystal Structure of the Invariant NK TCR: A Molecular Basis for iNKT Cell Autoreactivity and Recognition of CD1d-self antigen

Monday, January 10 | 2:30PM - 4:30PM
Workshop 1: Recognition by NK/NKT Receptors
Room: Peaks 4-5

Speaker 3 of 7
Sandeep K. Tripathy, Washington University School of Medicine, USA
Activation Receptor-Mediated Modulation of Natural Killer Cell Tolerance in vivo

Monday, January 10 | 2:30PM - 4:30PM
Workshop 1: Recognition by NK/NKT Receptors
Room: Peaks 4-5

Speaker 4 of 7
Carsten Watzl, IfADo, Germany
2B4-Mediated Co-Activation of NK Cells Induces Rapid LFA-1-Dependent Adhesion to Tumor Cells as Measured by Single Cell Force Spectroscopy

Monday, January 10 | 2:30PM - 4:30PM
Workshop 1: Recognition by NK/NKT Receptors
Room: Peaks 4-5

Speaker 5 of 7
Erin J. Adams, University of Chicago, USA
Molecular Studies of NKT Cell Recognition of CD1d Presenting the Self Lipid, Lysophosphatidylcholine

Monday, January 10 | 2:30PM - 4:30PM
Workshop 1: Recognition by NK/NKT Receptors
Room: Peaks 4-5

Speaker 6 of 7
Susanna Cardell, Göteborg University, Sweden
A Search for Endogenous Glycolipid Ligands Activating Autoreactive Type II NKT Cells

Monday, January 10 | 2:30PM - 4:30PM
Workshop 1: Recognition by NK/NKT Receptors
Room: Peaks 4-5

Speaker 7 of 7
Peter van den Elzen, University of British Columbia, Canada
Autoimmune Recognition of Sulfatide bz Human Invariant NKT Cells

Monday, January 10 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, January 10 | 5:00PM - 7:00PM
NK and NKT Cell Activation
Room: Peaks 4-5

Speaker 1 of 5
André Veillette, Institut de Recherches Cliniques de Montreal, Canada
NK Cell Regulation by the SLAM and SAP Families

Monday, January 10 | 5:00PM - 7:00PM
NK and NKT Cell Activation
Room: Peaks 4-5

Speaker 2 of 5
Subramaniam Malarkannan, Blood Center of Wisconsin, USA
Short Talk: Rap1b Facilitates NK Cell Functions via IQGAP1-Mediated Signalosomes

Monday, January 10 | 5:00PM - 7:00PM
NK and NKT Cell Activation
Room: Peaks 4-5

Speaker 3 of 5
Jamie Rossjohn, Monash University, Australia
Recent Insights into NKT TCR Recognition

Monday, January 10 | 5:00PM - 7:00PM
NK and NKT Cell Activation
Room: Peaks 4-5

Speaker 4 of 5
Taishan Hu, Oklahoma Medical Research Foundation, USA
Short Talk: The RAS/MAPK Signaling Cascade is Critically Required for iNKT Cell Development

Monday, January 10 | 5:00PM - 7:00PM
NK and NKT Cell Activation
Room: Peaks 4-5

Speaker 5 of 5
* Lewis L. Lanier, University of California, San Francisco, USA
How do NK Cells Sense their Environment and Respond?

Monday, January 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3


Monday, January 10 | 7:30PM - 10:00PM
Poster Session 1
Room: Peaks 1-3


Tuesday, January 11 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Tuesday, January 11 | 8:00AM - 11:15AM
Dissecting NK and NKT
Room: Peaks 4-5

Speaker 1 of 6
Christian Münz, University of Zurich, Switzerland
Human NK Cell Compartments and Their Activation by Dendritic Cells

Tuesday, January 11 | 8:00AM - 11:15AM
Dissecting NK and NKT
Room: Peaks 4-5

Speaker 2 of 6
Peggy Riese, Helmholtz Center for Infection Research, Germany
Immune Intervention against HCV Infection Utilizing a Pegylated Derivative of the NKT Aganoist alphaGalCer

Tuesday, January 11 | 8:00AM - 11:15AM
Dissecting NK and NKT
Room: Peaks 4-5

Speaker 3 of 6
Pooja Arora, Albert Einstein College of Medicine, USA
Short talk: Tuning of iNKT Cell Responses: How Ligand Structure Directs Cytokine Secretion

Tuesday, January 11 | 8:00AM - 11:15AM
Dissecting NK and NKT
Room: Peaks 4-5

Speaker 4 of 6
Daniel M. Davis, Imperial College London, UK
Imaging NK Cell Interactions

Tuesday, January 11 | 8:00AM - 11:15AM
Dissecting NK and NKT
Room: Peaks 4-5

Speaker 5 of 6
Ling-Pei Ho, Weatherall Institute of Molecular Medicine, UK
Short Talk: Inflammatory Monocytes are the Major Cell Infiltrate to the Lungs during Lethal Influenza A Virus Infection, and can be Controlled by iNKT Cells

Tuesday, January 11 | 8:00AM - 11:15AM
Dissecting NK and NKT
Room: Peaks 4-5

Speaker 6 of 6
* Michael B. Brenner, Harvard Medical School, USA
Mechanisms that Drive NKT Activation

Tuesday, January 11 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, January 11 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Tuesday, January 11 | 11:15AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Tuesday, January 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Tuesday, January 11 | 2:30PM - 4:30PM
Workshop 2: Studying NK and NKT Cells in situ
Room: Peaks 4-5

Speaker 1 of 9
* Eleanor M. Riley, Roslin Institute, UK

Tuesday, January 11 | 2:30PM - 4:30PM
Workshop 2: Studying NK and NKT Cells in situ
Room: Peaks 4-5

Speaker 2 of 9
* James P. Di Santo, Institut Pasteur, France

Tuesday, January 11 | 2:30PM - 4:30PM
Workshop 2: Studying NK and NKT Cells in situ
Room: Peaks 4-5

Speaker 3 of 9
† Zacarias Garcia, Pasteur Institute, France
Dynamics of NK Cell Activation Following Administration of an MVA-Based HIV Vaccine

Tuesday, January 11 | 2:30PM - 4:30PM
Workshop 2: Studying NK and NKT Cells in situ
Room: Peaks 4-5

Speaker 4 of 9
Morgan Huse, Memorial Sloan Kettering Cancer Center, USA
Inhibitory Receptor Signaling Dynamics in NK Cells

Tuesday, January 11 | 2:30PM - 4:30PM
Workshop 2: Studying NK and NKT Cells in situ
Room: Peaks 4-5

Speaker 5 of 9
James C. Whisstock, Monash University, Australia
The Structure of Lymphocyte Perforin and Pore Formation by Perforin

Tuesday, January 11 | 2:30PM - 4:30PM
Workshop 2: Studying NK and NKT Cells in situ
Room: Peaks 4-5

Speaker 6 of 9
Klaas P.J.M. Van Gisbergen, Sanquin Research, Netherlands
Hobit is an NKT Cell Specific Transcription Factor that Regulates Cytotoxicity

Tuesday, January 11 | 2:30PM - 4:30PM
Workshop 2: Studying NK and NKT Cells in situ
Room: Peaks 4-5

Speaker 7 of 9
Ernesto Merino Plaza, Memorial Sloan-Kettering Cancer Center, USA
PKC-theta Regulatory Domain is Necessary for Protein Cluster Formation in Response to ITAM-Mediated NK Cell Activation

Tuesday, January 11 | 2:30PM - 4:30PM
Workshop 2: Studying NK and NKT Cells in situ
Room: Peaks 4-5

Speaker 8 of 9
Rupali Das, Children's Hospital of Philadelphia, USA
Dichotomous Roles for SAP in Mature NKT Cell Functions

Tuesday, January 11 | 2:30PM - 4:30PM
Workshop 2: Studying NK and NKT Cells in situ
Room: Peaks 4-5

Speaker 9 of 9
Patricia Barral, Cancer Research UK. London Research Institute, UK
CD169+ Macrophages Present Lipid Antigens to Mediate Early Activation of Invariant NKT Cells in Lymph Nodes

Tuesday, January 11 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, January 11 | 5:00PM - 7:00PM
Mucosal NK and NKT Cells
Room: Peaks 4-5

Speaker 1 of 5
* Marco Colonna, Washington University School of Medicine, USA
Human NK22 Cells un Mucosal Immunity

Tuesday, January 11 | 5:00PM - 7:00PM
Mucosal NK and NKT Cells
Room: Peaks 4-5

Speaker 2 of 5
Olivier Lantz, Institut Curie, France
Anti-Microbial Activity of MAIT Cells

Tuesday, January 11 | 5:00PM - 7:00PM
Mucosal NK and NKT Cells
Room: Peaks 4-5

Speaker 3 of 5
Magdalena Sips, Ragon Institute of MGH, MIT, and Harvard, USA
Short Talk: Significant Alterations in Natural Killer Cells in the Gastrointestinal Tract Following HIV Infection

Tuesday, January 11 | 5:00PM - 7:00PM
Mucosal NK and NKT Cells
Room: Peaks 4-5

Speaker 4 of 5
Andreas Diefenbach, Charité – Universitätsmedizin Berlin, Germany
Development and Function of Innate Lymphocytes at Mucosal Surfaces

Tuesday, January 11 | 5:00PM - 7:00PM
Mucosal NK and NKT Cells
Room: Peaks 4-5

Speaker 5 of 5
Laurent Brossay, Brown University, USA
Short Talk: Salivary Gland NK Cells are Phenotypically and Functionally Unique

Tuesday, January 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3


Tuesday, January 11 | 7:30PM - 10:00PM
Poster Session 2
Room: Peaks 1-3


Wednesday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Wednesday, January 12 | 8:00AM - 11:00AM
NK and NKT Cells in Inflammation
Room: Peaks 4-5

Speaker 1 of 5
* Bana Jabri, University of Chicago, USA
NKG2D and Stress-Specific Killing of Tissue Target Cells: Role in Autoimmunity

Wednesday, January 12 | 8:00AM - 11:00AM
NK and NKT Cells in Inflammation
Room: Peaks 4-5

Speaker 2 of 5
Masaru Taniguchi, RIKEN RCAI, Japan
iPS-Derived NKT Cells and their Adjuvant Effects

Wednesday, January 12 | 8:00AM - 11:00AM
NK and NKT Cells in Inflammation
Room: Peaks 4-5

Speaker 3 of 5
Ling-Pei Ho, Weatherall Institute of Molecular Medicine, UK
Short talk: iNKT Cells Improve Outcome in EAE Mice by Promoting the Differetiation of Inflammatory CD11b+Gr1mid Monocytes into Anti-Inflammatory Alternatively Activated Macrophages in the CNS

Wednesday, January 12 | 8:00AM - 11:00AM
NK and NKT Cells in Inflammation
Room: Peaks 4-5

Speaker 4 of 5
Joel Linden, La Jolla Institute for Allergy and Immunology, USA
Induction of Anti-Inflammatory Adenosine A2A and A2B Receptor Transcripts, CD39 and CD73 on NKT, NK and T Cells in Response to alpha-GalCer or Ischemia-Reperfusion Injury

Wednesday, January 12 | 8:00AM - 11:00AM
NK and NKT Cells in Inflammation
Room: Peaks 4-5

Speaker 5 of 5
Ofer Mandelboim, Hebrew University, Israel
Cellular and Viral mircoRNAs Controlling the Immune Response to Stress

Wednesday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, January 12 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Wednesday, January 12 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Wednesday, January 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Wednesday, January 12 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, January 12 | 5:00PM - 7:00PM
NK and NKT Cells in Bacterial and Parasitic Infection
Room: Peaks 4-5

Speaker 1 of 5
* Eleanor M. Riley, Roslin Institute, UK
Natural Killer Cells as Effectors of Vaccine-Induced Immunity?

Wednesday, January 12 | 5:00PM - 7:00PM
NK and NKT Cells in Bacterial and Parasitic Infection
Room: Peaks 4-5

Speaker 2 of 5
Daniela S. Herzig, University of Texas Medical Branch, USA
Short Talk: Regulation of NK Cell Function during Acute Bacterial Peritonitis by CXCR3

Wednesday, January 12 | 5:00PM - 7:00PM
NK and NKT Cells in Bacterial and Parasitic Infection
Room: Peaks 4-5

Speaker 3 of 5
* Mitchell Kronenberg, La Jolla Institute for Allergy and Immunology, USA
NKT Antigens from the Elements: Earth, Water, and Air

Wednesday, January 12 | 5:00PM - 7:00PM
NK and NKT Cells in Bacterial and Parasitic Infection
Room: Peaks 4-5

Speaker 4 of 5
Nadia Cohen, Harvard University, USA
Short talk: The Anti-Fungal NKT Cell Response

Wednesday, January 12 | 5:00PM - 7:00PM
NK and NKT Cells in Bacterial and Parasitic Infection
Room: Peaks 4-5

Speaker 5 of 5
James P. Di Santo, Institut Pasteur, France
An Emerging Family of Immune Effectors

Wednesday, January 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3


Wednesday, January 12 | 7:30PM - 10:00PM
Poster Session 3
Room: Peaks 1-3


Thursday, January 13 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Thursday, January 13 | 8:00AM - 11:15AM
NK and NKT Cells in the Anti-Tumor Response
Room: Peaks 4-5

Speaker 1 of 6
* David H. Raulet, University of California, Berkeley, USA
NK Cells and NKG2D in Tumor Surveillance

Thursday, January 13 | 8:00AM - 11:15AM
NK and NKT Cells in the Anti-Tumor Response
Room: Peaks 4-5

Speaker 2 of 6
Jay A. Berzofsky, NCI, National Institutes of Health, USA
Short Talk: Novel Agonist of Mouse and Human iNKT Cells Reveals a New Mechanism of Tumor Immunity

Thursday, January 13 | 8:00AM - 11:15AM
NK and NKT Cells in the Anti-Tumor Response
Room: Peaks 4-5

Speaker 3 of 6
Michael Nowak, University of Bonn, Germany
Short Talk: Defective NKT Cell Activation by CD1d+ TRAMP Prostate Tumor Cells is Corrected by Interleukin-12 with alpha-Galactosylceramide

Thursday, January 13 | 8:00AM - 11:15AM
NK and NKT Cells in the Anti-Tumor Response
Room: Peaks 4-5

Speaker 4 of 6
Philippe Bousso, Institute Pasteur, France
NK Cell Interactions during Activation and Killing: Lessons from in vivo Imaging

Thursday, January 13 | 8:00AM - 11:15AM
NK and NKT Cells in the Anti-Tumor Response
Room: Peaks 4-5

Speaker 5 of 6
Leonid S. Metelitsa, Baylor College of Medicine, USA
Anti-tumor Potential of Type-I NKT Cells Against CD1d-Positive and CD1d-Negative Tumors in Humans

Thursday, January 13 | 8:00AM - 11:15AM
NK and NKT Cells in the Anti-Tumor Response
Room: Peaks 4-5

Speaker 6 of 6
François Romagné, Innate Pharma, France
Pharmacological Aspects of the Development of Anti-KIR Antibodies

Thursday, January 13 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, January 13 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Thursday, January 13 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, January 13 | 5:00PM - 7:00PM
NK and NKT Cells in Viral Infection
Room: Peaks 4-5

Speaker 1 of 5
Mary Carrington, NCI, National Institutes of Health, USA
Immunogenetic Variation Characterizing Exceptional Control of HIV

Thursday, January 13 | 5:00PM - 7:00PM
NK and NKT Cells in Viral Infection
Room: Peaks 4-5

Speaker 2 of 5
* Hans-Gustaf Ljunggren, Karolinska Institutet, Sweden
Short Talk: The Human NK Cell Response to Puumala Hantavirus Infection

Thursday, January 13 | 5:00PM - 7:00PM
NK and NKT Cells in Viral Infection
Room: Peaks 4-5

Speaker 3 of 5
Sandra L. Lopez-Verges, University of California, San Francisco, USA
Short Talk: A New Subset of CD57+NKG2Chi NK Cells is Observed after HCMV Infection

Thursday, January 13 | 5:00PM - 7:00PM
NK and NKT Cells in Viral Infection
Room: Peaks 4-5

Speaker 4 of 5
Agnès C. Lehuen, Institut Cochin, France
Role of iNKT Cells from Infection to Type 1 Diabetes

Thursday, January 13 | 5:00PM - 7:00PM
NK and NKT Cells in Viral Infection
Room: Peaks 4-5

Speaker 5 of 5
Moriya Tsuji, Aaron Diamond AIDS Research Center (ADARC), USA
Clinical Development of 7DW8-5 – A Novel Glycolipid Vaccine Adjuvant

Thursday, January 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breckenridge Ballroom


Thursday, January 13 | 8:00PM - 11:00PM
Entertainment
Room: Breckenridge Ballroom


Thursday, January 13 | 8:00PM - 11:00PM
Cash Bar
Room: Breckenridge Ballroom


Friday, January 14 | 10:25AM - 10:25AM
Departure


*Session Chair.