Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Chromatin Architecture and Chromosome Organization (2018X5)
Chromatin and Epigenetics (2016C2)
Chromatin Mechanisms and Cell Physiology (2014C5)
Chromatin Dynamics (2012J4)

Web Desc
Histone Code: Fact or Fiction? Organizer(s): Karolin Luger, James Davie and Joanna Wysocka Date: January 10 - 15, 2011 Location: Zermatt Resort & Spa - Utah, Midway, Utah, USA Sponsored by Pfizer Inc. For important information on the coronavirus, please click here Summary of Meeting: It has become customary to refer to posttranslational histone modifications in all contexts as “epigenetic”, and to refer to a histone ‘code’. In certain contexts, histone modifications contribute to the epigenetic maintenance, whereas in others, they don’t. Similarly, some of the phenomena attributed to the posttranslational modification of histones do not fall into the strict definition of a ‘histone code’. This meeting strives to bring together scientists from different ‘camps’, to illuminate the effects of posttranslational modifications from many viewpoints. The emphasis here is on the effect of PTMs on the structure and readout of the genome, and less on the enzymatic activities and their regulation. Speakers will be encouraged to engage in rigorous discussion, as is obvious in the format for the opening and closing session which will be held in discussion format. In particular, we plan to • Investigate how histone modifications participate in the maintenance of epigenetic information • Elaborate on recent findings that epigenetic states are likely conveyed as a dynamic equilibrium of opposing modifying activities that involves feedback loops, and talk about ‘epigenetic memory’ • How do histone modifications affect nucleosome / chromatin structure and stability / interaction with chromatin architectural proteins? • Discuss the responsiveness of the epigenetic process, and the 3-D interplay in the nuclear environment that ultimately decides which gene will be fired up. • Have a workshop highlighting newest approaches / technologies to study histone modification states. • Have a final round table discussion to perhaps re-define and tighten up terminology, and to consolidate viewpoints where possible. Scholarship Deadline: September 16 2010 Discounted Abstract Deadline: September 16 2010 Abstract Deadline: October 13 2010 Discounted Registration Deadline: November 10 2010 We gratefully acknowledge additional support for this conference from: Yamini Dalal We gratefully acknowledge the generous grant for this conference provided by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Grant No. 5R13DK084688-02 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Histone Code: Fact or Fiction?

Organizer(s): Karolin Luger, James Davie and Joanna Wysocka

Date: January 10 - 15, 2011
Location: Zermatt Resort & Spa - Utah, Midway, Utah, USA

Program


Monday, January 10 \| 3:00PM - 7:30PM Registration Room: Matterhorn Foyer
Monday, January 10 \| 6:15PM - 7:15PM Refreshments Room: Matterhorn Foyer/Mtn Rosa
Monday, January 10 \| 7:15PM - 9:30PM Welcome and Keynote Session Room: Matterhorn Ballroom Discuss ‘histone code’ and give a historic perspective. Speaker 1 of 2 Bryan M. Turner, University of Birmingham, UK Evolution of the Histone Code “Historical Perspective”
Monday, January 10 \| 7:15PM - 9:30PM Welcome and Keynote Session Room: Matterhorn Ballroom Discuss ‘histone code’ and give a historic perspective. Speaker 2 of 2 C. David Allis, Rockefeller University, USA A Historical Journey towards and beyond the “Histone Code” hypothesis
Tuesday, January 11 \| 6:30AM - 8:00AM Breakfast Room: Bernese Event Center
Tuesday, January 11 \| 8:00AM - 11:15AM Relationship between Epigenetics and Histone Modifications Room: Matterhorn Ballroom Highlight the most recent evidence that histone modifications participate in the maintenance of epigenetic information: (i) Discuss how histone modifications contribute to the maintenance of gene expression patterns (ii) Show recent evidence on how epigenetic states can be reversed (e.g. during reprogramming) (iii) Highlight progress that has been made on the mechanisms of transmission of histone modifications during replication Speaker 1 of 7 * Siavash K. Kurdistani, University of California, Los Angeles, USA
Tuesday, January 11 \| 8:00AM - 11:15AM Relationship between Epigenetics and Histone Modifications Room: Matterhorn Ballroom Highlight the most recent evidence that histone modifications participate in the maintenance of epigenetic information: (i) Discuss how histone modifications contribute to the maintenance of gene expression patterns (ii) Show recent evidence on how epigenetic states can be reversed (e.g. during reprogramming) (iii) Highlight progress that has been made on the mechanisms of transmission of histone modifications during replication Speaker 2 of 7 Danesh Moazed, Harvard Medical School, USA Histone Modifications in Heterochromatin Assembly and Propagation
Tuesday, January 11 \| 8:00AM - 11:15AM Relationship between Epigenetics and Histone Modifications Room: Matterhorn Ballroom Highlight the most recent evidence that histone modifications participate in the maintenance of epigenetic information: (i) Discuss how histone modifications contribute to the maintenance of gene expression patterns (ii) Show recent evidence on how epigenetic states can be reversed (e.g. during reprogramming) (iii) Highlight progress that has been made on the mechanisms of transmission of histone modifications during replication Speaker 3 of 7 Nicole J. Francis, Institut de Recherches Cliniques de Montreal, Canada Investigating the Mechanism and Maintenance of Polycomb Group proteins proteins on Chromatin through DNA Replication
Tuesday, January 11 \| 8:00AM - 11:15AM Relationship between Epigenetics and Histone Modifications Room: Matterhorn Ballroom Highlight the most recent evidence that histone modifications participate in the maintenance of epigenetic information: (i) Discuss how histone modifications contribute to the maintenance of gene expression patterns (ii) Show recent evidence on how epigenetic states can be reversed (e.g. during reprogramming) (iii) Highlight progress that has been made on the mechanisms of transmission of histone modifications during replication Speaker 4 of 7 Barbara Panning, University of California, San Francisco, USA Epigenetic Regulation of Embryonic Stem Cell Self-Renewal
Tuesday, January 11 \| 8:00AM - 11:15AM Relationship between Epigenetics and Histone Modifications Room: Matterhorn Ballroom Highlight the most recent evidence that histone modifications participate in the maintenance of epigenetic information: (i) Discuss how histone modifications contribute to the maintenance of gene expression patterns (ii) Show recent evidence on how epigenetic states can be reversed (e.g. during reprogramming) (iii) Highlight progress that has been made on the mechanisms of transmission of histone modifications during replication Speaker 5 of 7 Stavros Lomvardas, Columbia University, USA Short Talk: The Histone Thingy as a Postal Code
Tuesday, January 11 \| 8:00AM - 11:15AM Relationship between Epigenetics and Histone Modifications Room: Matterhorn Ballroom Highlight the most recent evidence that histone modifications participate in the maintenance of epigenetic information: (i) Discuss how histone modifications contribute to the maintenance of gene expression patterns (ii) Show recent evidence on how epigenetic states can be reversed (e.g. during reprogramming) (iii) Highlight progress that has been made on the mechanisms of transmission of histone modifications during replication Speaker 6 of 7 Bharat D. Reddy, bluebird bio, USA Short Talk: DeMYSTifying Heterochromatin
Tuesday, January 11 \| 8:00AM - 11:15AM Relationship between Epigenetics and Histone Modifications Room: Matterhorn Ballroom Highlight the most recent evidence that histone modifications participate in the maintenance of epigenetic information: (i) Discuss how histone modifications contribute to the maintenance of gene expression patterns (ii) Show recent evidence on how epigenetic states can be reversed (e.g. during reprogramming) (iii) Highlight progress that has been made on the mechanisms of transmission of histone modifications during replication Speaker 7 of 7 Joanna Wysocka, Stanford University, USA A Unique Chromatin Signature Identifies Early Developmental Enhancers in Humans
Tuesday, January 11 \| 9:20AM - 9:40AM Coffee Break Room: Matterhorn Foyer
Tuesday, January 11 \| 11:15AM - 1:00PM Poster Setup Room: Bernese Event Center
Tuesday, January 11 \| 1:00PM - 10:00PM Poster Viewing Room: Bernese Event Center
Tuesday, January 11 \| 1:00PM - 1:00PM On Own for Lunch and Recreation
Tuesday, January 11 \| 4:30PM - 5:00PM Coffee Available Room: Matterhorn Foyer
Tuesday, January 11 \| 5:00PM - 7:00PM Re-Programming Epigenetic States Room: Matterhorn Ballroom Speaker 1 of 6 * Joanna Wysocka, Stanford University, USA
Tuesday, January 11 \| 5:00PM - 7:00PM Re-Programming Epigenetic States Room: Matterhorn Ballroom Speaker 2 of 6 Azim Surani, University of Cambridge, UK Role of Epigenetic Mechanisms in the Establishment and Regulation of Mouse Germ Cells
Tuesday, January 11 \| 5:00PM - 7:00PM Re-Programming Epigenetic States Room: Matterhorn Ballroom Speaker 3 of 6 Siavash K. Kurdistani, University of California, Los Angeles, USA Regulating Global Levels of Histone Modifications
Tuesday, January 11 \| 5:00PM - 7:00PM Re-Programming Epigenetic States Room: Matterhorn Ballroom Speaker 4 of 6 Yehudit Bergman, Hebrew University Medical School, Israel Short Talk: Epigenetic Control of Immunoglobulin Allelic Exclusion
Tuesday, January 11 \| 5:00PM - 7:00PM Re-Programming Epigenetic States Room: Matterhorn Ballroom Speaker 5 of 6 Cheng-Ran Xu, Peking University, China Short Talk: Chromatin Modifiers in Embryonic Endoderm Cells Promote Differential Induction of Liver or Pancreas
Tuesday, January 11 \| 5:00PM - 7:00PM Re-Programming Epigenetic States Room: Matterhorn Ballroom Speaker 6 of 6 Emily Bernstein, Mount Sinai School of Medicine, USA Short Talk: The Histone Variant macroH2A Suppresses Progression of Malignant Melanoma
Tuesday, January 11 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Bernese Event Center
Tuesday, January 11 \| 7:30PM - 10:00PM Poster Session 1 Room: Bernese Event Center
Wednesday, January 12 \| 6:30AM - 8:00AM Breakfast Room: Bernese Event Center
Wednesday, January 12 \| 8:00AM - 11:15AM Mechanistic Nature of Epigenetic Memory Room: Matterhorn Ballroom Understood as propagation of gene expression patterns over many cell generations. A static model of epigenetic memory that relies on the stability of modification mark on a given nucleosome is dead. Instead, it becomes increasingly clear that epigenetic states are likely conveyed as a dynamic equilibrium of opposing modifying activities such as methyltransferases and demethylases that involves feedback loops. Note that to some extent the preceding session has covered some of these topics. There is recent theoretical work (e.g. Dodd et al., Cell 2007) that propose a dynamic model of epigenetic memory based on bistability. This model has some fascinating predictions. Unfortunately, it seems it received less attention from the field than it should (as someone put it, “biologists are a fearful bunch”). Topics to be covered: (i) To have a theoretical biology component, hopefully presented in a way that is accessible to biologists (ii) To discuss existing evidence on feedback loops involving histone modifications and their integration with transcriptional networks; also discussion what is the role of transcription factors in epigenetic memory (iii) Experimental models of epigenetic memory (iv) Role of chromatin in dampening transcriptional noise Speaker 1 of 8 * Laurie A. Boyer, Massachusetts Institute of Technology, USA
Wednesday, January 12 \| 8:00AM - 11:15AM Mechanistic Nature of Epigenetic Memory Room: Matterhorn Ballroom Understood as propagation of gene expression patterns over many cell generations. A static model of epigenetic memory that relies on the stability of modification mark on a given nucleosome is dead. Instead, it becomes increasingly clear that epigenetic states are likely conveyed as a dynamic equilibrium of opposing modifying activities such as methyltransferases and demethylases that involves feedback loops. Note that to some extent the preceding session has covered some of these topics. There is recent theoretical work (e.g. Dodd et al., Cell 2007) that propose a dynamic model of epigenetic memory based on bistability. This model has some fascinating predictions. Unfortunately, it seems it received less attention from the field than it should (as someone put it, “biologists are a fearful bunch”). Topics to be covered: (i) To have a theoretical biology component, hopefully presented in a way that is accessible to biologists (ii) To discuss existing evidence on feedback loops involving histone modifications and their integration with transcriptional networks; also discussion what is the role of transcription factors in epigenetic memory (iii) Experimental models of epigenetic memory (iv) Role of chromatin in dampening transcriptional noise Speaker 2 of 8 Ian Dodd, University of Adelaide, Australia Modeling Cell Memory by Nucleosome Modification Containment – Defining Chromatin Regions
Wednesday, January 12 \| 8:00AM - 11:15AM Mechanistic Nature of Epigenetic Memory Room: Matterhorn Ballroom Understood as propagation of gene expression patterns over many cell generations. A static model of epigenetic memory that relies on the stability of modification mark on a given nucleosome is dead. Instead, it becomes increasingly clear that epigenetic states are likely conveyed as a dynamic equilibrium of opposing modifying activities such as methyltransferases and demethylases that involves feedback loops. Note that to some extent the preceding session has covered some of these topics. There is recent theoretical work (e.g. Dodd et al., Cell 2007) that propose a dynamic model of epigenetic memory based on bistability. This model has some fascinating predictions. Unfortunately, it seems it received less attention from the field than it should (as someone put it, “biologists are a fearful bunch”). Topics to be covered: (i) To have a theoretical biology component, hopefully presented in a way that is accessible to biologists (ii) To discuss existing evidence on feedback loops involving histone modifications and their integration with transcriptional networks; also discussion what is the role of transcription factors in epigenetic memory (iii) Experimental models of epigenetic memory (iv) Role of chromatin in dampening transcriptional noise Speaker 3 of 8 Jürg Müller, Max Planck Institute of Biochemistry, Germany Molecular Mechanisms of the Polycomb/Trithorax System
Wednesday, January 12 \| 8:00AM - 11:15AM Mechanistic Nature of Epigenetic Memory Room: Matterhorn Ballroom Understood as propagation of gene expression patterns over many cell generations. A static model of epigenetic memory that relies on the stability of modification mark on a given nucleosome is dead. Instead, it becomes increasingly clear that epigenetic states are likely conveyed as a dynamic equilibrium of opposing modifying activities such as methyltransferases and demethylases that involves feedback loops. Note that to some extent the preceding session has covered some of these topics. There is recent theoretical work (e.g. Dodd et al., Cell 2007) that propose a dynamic model of epigenetic memory based on bistability. This model has some fascinating predictions. Unfortunately, it seems it received less attention from the field than it should (as someone put it, “biologists are a fearful bunch”). Topics to be covered: (i) To have a theoretical biology component, hopefully presented in a way that is accessible to biologists (ii) To discuss existing evidence on feedback loops involving histone modifications and their integration with transcriptional networks; also discussion what is the role of transcription factors in epigenetic memory (iii) Experimental models of epigenetic memory (iv) Role of chromatin in dampening transcriptional noise Speaker 4 of 8 Ziyang Ma, Stanford University, USA Short Talk: Prdm14 is a Sequence-Specific Transcriptional Regulator Promoting ESC Gene Expression Programs
Wednesday, January 12 \| 8:00AM - 11:15AM Mechanistic Nature of Epigenetic Memory Room: Matterhorn Ballroom Understood as propagation of gene expression patterns over many cell generations. A static model of epigenetic memory that relies on the stability of modification mark on a given nucleosome is dead. Instead, it becomes increasingly clear that epigenetic states are likely conveyed as a dynamic equilibrium of opposing modifying activities such as methyltransferases and demethylases that involves feedback loops. Note that to some extent the preceding session has covered some of these topics. There is recent theoretical work (e.g. Dodd et al., Cell 2007) that propose a dynamic model of epigenetic memory based on bistability. This model has some fascinating predictions. Unfortunately, it seems it received less attention from the field than it should (as someone put it, “biologists are a fearful bunch”). Topics to be covered: (i) To have a theoretical biology component, hopefully presented in a way that is accessible to biologists (ii) To discuss existing evidence on feedback loops involving histone modifications and their integration with transcriptional networks; also discussion what is the role of transcription factors in epigenetic memory (iii) Experimental models of epigenetic memory (iv) Role of chromatin in dampening transcriptional noise Speaker 5 of 8 Tasuku Kitada, Massachusetts Institute of Technology, USA Short Talk: Deciphering the 'Epigenetic Switch' for Budding Yeast Telomere Position Effect
Wednesday, January 12 \| 8:00AM - 11:15AM Mechanistic Nature of Epigenetic Memory Room: Matterhorn Ballroom Understood as propagation of gene expression patterns over many cell generations. A static model of epigenetic memory that relies on the stability of modification mark on a given nucleosome is dead. Instead, it becomes increasingly clear that epigenetic states are likely conveyed as a dynamic equilibrium of opposing modifying activities such as methyltransferases and demethylases that involves feedback loops. Note that to some extent the preceding session has covered some of these topics. There is recent theoretical work (e.g. Dodd et al., Cell 2007) that propose a dynamic model of epigenetic memory based on bistability. This model has some fascinating predictions. Unfortunately, it seems it received less attention from the field than it should (as someone put it, “biologists are a fearful bunch”). Topics to be covered: (i) To have a theoretical biology component, hopefully presented in a way that is accessible to biologists (ii) To discuss existing evidence on feedback loops involving histone modifications and their integration with transcriptional networks; also discussion what is the role of transcription factors in epigenetic memory (iii) Experimental models of epigenetic memory (iv) Role of chromatin in dampening transcriptional noise Speaker 6 of 8 Yohei Hayashi, Tohoku University, Japan Short Talk: Network-Based Histone “Modification Web” Theory and “DESS” Strategy for Elucidating the Physiological Significance of Histone Modifications
Wednesday, January 12 \| 8:00AM - 11:15AM Mechanistic Nature of Epigenetic Memory Room: Matterhorn Ballroom Understood as propagation of gene expression patterns over many cell generations. A static model of epigenetic memory that relies on the stability of modification mark on a given nucleosome is dead. Instead, it becomes increasingly clear that epigenetic states are likely conveyed as a dynamic equilibrium of opposing modifying activities such as methyltransferases and demethylases that involves feedback loops. Note that to some extent the preceding session has covered some of these topics. There is recent theoretical work (e.g. Dodd et al., Cell 2007) that propose a dynamic model of epigenetic memory based on bistability. This model has some fascinating predictions. Unfortunately, it seems it received less attention from the field than it should (as someone put it, “biologists are a fearful bunch”). Topics to be covered: (i) To have a theoretical biology component, hopefully presented in a way that is accessible to biologists (ii) To discuss existing evidence on feedback loops involving histone modifications and their integration with transcriptional networks; also discussion what is the role of transcription factors in epigenetic memory (iii) Experimental models of epigenetic memory (iv) Role of chromatin in dampening transcriptional noise Speaker 7 of 8 William H. Light, Northwestern University, USA Short Talk: Interaction of a DNA Zip Code with the Nuclear Pore Complex Promotes H2A.Z Incorporation and Transcriptional Memory
Wednesday, January 12 \| 8:00AM - 11:15AM Mechanistic Nature of Epigenetic Memory Room: Matterhorn Ballroom Understood as propagation of gene expression patterns over many cell generations. A static model of epigenetic memory that relies on the stability of modification mark on a given nucleosome is dead. Instead, it becomes increasingly clear that epigenetic states are likely conveyed as a dynamic equilibrium of opposing modifying activities such as methyltransferases and demethylases that involves feedback loops. Note that to some extent the preceding session has covered some of these topics. There is recent theoretical work (e.g. Dodd et al., Cell 2007) that propose a dynamic model of epigenetic memory based on bistability. This model has some fascinating predictions. Unfortunately, it seems it received less attention from the field than it should (as someone put it, “biologists are a fearful bunch”). Topics to be covered: (i) To have a theoretical biology component, hopefully presented in a way that is accessible to biologists (ii) To discuss existing evidence on feedback loops involving histone modifications and their integration with transcriptional networks; also discussion what is the role of transcription factors in epigenetic memory (iii) Experimental models of epigenetic memory (iv) Role of chromatin in dampening transcriptional noise Speaker 8 of 8 Steven Henikoff, Fred Hutchinson Cancer Research Center, USA Histone Variant Dynamics and Epigenetics
Wednesday, January 12 \| 9:20AM - 9:40AM Coffee Break Room: Matterhorn Foyer
Wednesday, January 12 \| 11:15AM - 1:00PM Poster Setup Room: Bernese Event Center
Wednesday, January 12 \| 1:00PM - 10:00PM Poster Viewing Room: Bernese Event Center
Wednesday, January 12 \| 1:00PM - 1:00PM On Own for Lunch and Recreation
Wednesday, January 12 \| 2:30PM - 4:30PM Workshop 1: Hot Topics Room: Matterhorn Ballroom Speaker 1 of 8 * James R. Davie, University of Manitoba, Canada
Wednesday, January 12 \| 2:30PM - 4:30PM Workshop 1: Hot Topics Room: Matterhorn Ballroom Speaker 2 of 8 Samuel G. Cox, University of Southern California, USA A Dominant Variant Histone H3.3 Mutant Reveals a Unique Epigenetic Remodeling Event in the Specification of the Multipotent Cranial Neural Crest
Wednesday, January 12 \| 2:30PM - 4:30PM Workshop 1: Hot Topics Room: Matterhorn Ballroom Speaker 3 of 8 Alexandre M. Erkine, Butler University, USA Activator - Histone Interactions: Fact or Fiction?
Wednesday, January 12 \| 2:30PM - 4:30PM Workshop 1: Hot Topics Room: Matterhorn Ballroom Speaker 4 of 8 Alea A. Mills, Cold Spring Harbor Laboratory, USA PHD-mediated H3K4me0 Binding is Essential for the Tumor Suppressive Function of CHD5
Wednesday, January 12 \| 2:30PM - 4:30PM Workshop 1: Hot Topics Room: Matterhorn Ballroom Speaker 5 of 8 Mekonnen Lemma Dechassa, Colorado State University, USA Structure and Scm3 Mediated Assembly of Budding Yeast Centromeric Nucleosomes
Wednesday, January 12 \| 2:30PM - 4:30PM Workshop 1: Hot Topics Room: Matterhorn Ballroom Speaker 6 of 8 Yamini Dalal, NCI, National Institutes of Health, USA Centromeric Histone H3 Dynamics in Human Disease, Differentiation and Repair
Wednesday, January 12 \| 2:30PM - 4:30PM Workshop 1: Hot Topics Room: Matterhorn Ballroom Speaker 7 of 8 Jun Liu, Indiana University Bloomington, USA Is there a Histone Code for Origins of DNA Replication?
Wednesday, January 12 \| 2:30PM - 4:30PM Workshop 1: Hot Topics Room: Matterhorn Ballroom Speaker 8 of 8 Vamsi Gangaraju, Medical University of South Carolina, USA Drosophila Piwi Functions in Hsp90-Mediated Suppression of Phenotypic Variation
Wednesday, January 12 \| 4:30PM - 5:00PM Coffee Available Room: Matterhorn Foyer
Wednesday, January 12 \| 5:00PM - 7:00PM Epigenomics and Roadmaps Room: Matterhorn Ballroom Speaker 1 of 5 * Yang Shi, Children's Hospital Boston, Harvard Medical School, USA
Wednesday, January 12 \| 5:00PM - 7:00PM Epigenomics and Roadmaps Room: Matterhorn Ballroom Speaker 2 of 5 Laurie A. Boyer, Massachusetts Institute of Technology, USA Chromatin States and Cell Fate: A Role for H2A.Z
Wednesday, January 12 \| 5:00PM - 7:00PM Epigenomics and Roadmaps Room: Matterhorn Ballroom Speaker 3 of 5 James R. Davie, University of Manitoba, Canada Nucleosomal Response and Immediate-Early Gene Expression
Wednesday, January 12 \| 5:00PM - 7:00PM Epigenomics and Roadmaps Room: Matterhorn Ballroom Speaker 4 of 5 B. Franklin Pugh, Pennsylvania State University, USA Nucleosome Organization, Modifications States, and Gene Regulation during a Yeast Developmental Pathway
Wednesday, January 12 \| 5:00PM - 7:00PM Epigenomics and Roadmaps Room: Matterhorn Ballroom Speaker 5 of 5 Zhanxin Wang, Beijing Normal University, China Short Talk: Structural Insights into a PHD-Bromo Double “Reader” Domain in Recognizing Histone Modifications
Wednesday, January 12 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Bernese Event Center
Wednesday, January 12 \| 7:30PM - 10:00PM Poster Session 2 Room: Bernese Event Center
Thursday, January 13 \| 6:30AM - 8:00AM Breakfast Room: Bernese Event Center
Thursday, January 13 \| 8:00AM - 11:15AM Histone Modifications and Chromatin Structural Impact Room: Matterhorn Ballroom Up to now we have heard about epigenetic processes, their reversibility, epigenetic mechanisms and epigenomic roadmaps, now it is time to see how this information plays out. (i) What do histone modifications really do to nucleosome / chromatin structure and stability / interaction with chromatin architectural proteins? (ii) Code readers, emphasis on recognition and perhaps its combinatorial aspects Speaker 1 of 7 * Danesh Moazed, Harvard Medical School, USA
Thursday, January 13 \| 8:00AM - 11:15AM Histone Modifications and Chromatin Structural Impact Room: Matterhorn Ballroom Up to now we have heard about epigenetic processes, their reversibility, epigenetic mechanisms and epigenomic roadmaps, now it is time to see how this information plays out. (i) What do histone modifications really do to nucleosome / chromatin structure and stability / interaction with chromatin architectural proteins? (ii) Code readers, emphasis on recognition and perhaps its combinatorial aspects Speaker 2 of 7 Michael Guy Poirier, Ohio State University, USA Unlocking Nucleosome Dynamics and Remodeling with Histone Post-Translational Modifications
Thursday, January 13 \| 8:00AM - 11:15AM Histone Modifications and Chromatin Structural Impact Room: Matterhorn Ballroom Up to now we have heard about epigenetic processes, their reversibility, epigenetic mechanisms and epigenomic roadmaps, now it is time to see how this information plays out. (i) What do histone modifications really do to nucleosome / chromatin structure and stability / interaction with chromatin architectural proteins? (ii) Code readers, emphasis on recognition and perhaps its combinatorial aspects Speaker 3 of 7 David John Tremethick, Australian National University, Australia The Nucleosome Surface Regulates Chromatin Compaction and Couples it with Unique Functions
Thursday, January 13 \| 8:00AM - 11:15AM Histone Modifications and Chromatin Structural Impact Room: Matterhorn Ballroom Up to now we have heard about epigenetic processes, their reversibility, epigenetic mechanisms and epigenomic roadmaps, now it is time to see how this information plays out. (i) What do histone modifications really do to nucleosome / chromatin structure and stability / interaction with chromatin architectural proteins? (ii) Code readers, emphasis on recognition and perhaps its combinatorial aspects Speaker 4 of 7 Job Dekker, University of Massachusetts Medical School, USA Three-Dimensional Organization of Chromosomes
Thursday, January 13 \| 8:00AM - 11:15AM Histone Modifications and Chromatin Structural Impact Room: Matterhorn Ballroom Up to now we have heard about epigenetic processes, their reversibility, epigenetic mechanisms and epigenomic roadmaps, now it is time to see how this information plays out. (i) What do histone modifications really do to nucleosome / chromatin structure and stability / interaction with chromatin architectural proteins? (ii) Code readers, emphasis on recognition and perhaps its combinatorial aspects Speaker 5 of 7 Judith B. Zaugg, EMBL-EBI, UK Short Talk: A Four State Model of Promoter-Nucleosome Architecture
Thursday, January 13 \| 8:00AM - 11:15AM Histone Modifications and Chromatin Structural Impact Room: Matterhorn Ballroom Up to now we have heard about epigenetic processes, their reversibility, epigenetic mechanisms and epigenomic roadmaps, now it is time to see how this information plays out. (i) What do histone modifications really do to nucleosome / chromatin structure and stability / interaction with chromatin architectural proteins? (ii) Code readers, emphasis on recognition and perhaps its combinatorial aspects Speaker 6 of 7 Steven M. Johnson, Brigham Young University, USA Short Talk: Nucleosome Organization in Primary Human Cells
Thursday, January 13 \| 8:00AM - 11:15AM Histone Modifications and Chromatin Structural Impact Room: Matterhorn Ballroom Up to now we have heard about epigenetic processes, their reversibility, epigenetic mechanisms and epigenomic roadmaps, now it is time to see how this information plays out. (i) What do histone modifications really do to nucleosome / chromatin structure and stability / interaction with chromatin architectural proteins? (ii) Code readers, emphasis on recognition and perhaps its combinatorial aspects Speaker 7 of 7 Karolin Luger, University of Colorado Boulder, USA Intrinsic and Extrinsic Modulators of Chromatin Structure
Thursday, January 13 \| 9:20AM - 9:40AM Coffee Break Room: Matterhorn Foyer
Thursday, January 13 \| 11:15AM - 1:00PM Poster Setup Room: Bernese Event Center
Thursday, January 13 \| 1:00PM - 10:00PM Poster Viewing Room: Bernese Event Center
Thursday, January 13 \| 1:00PM - 1:00PM On Own for Lunch and Recreation
Thursday, January 13 \| 4:30PM - 5:00PM Coffee Available Room: Matterhorn Foyer
Thursday, January 13 \| 5:00PM - 7:00PM Combinatorial Readout of Histone PTMs Room: Matterhorn Ballroom Speaker 1 of 5 * Karolin Luger, University of Colorado Boulder, USA
Thursday, January 13 \| 5:00PM - 7:00PM Combinatorial Readout of Histone PTMs Room: Matterhorn Ballroom Speaker 2 of 5 Michael A. Shogren-Knaak, Iowa State University, USA Writing and Reading SAGA Autoacetylation in the Context of Nucleosome Acetylation
Thursday, January 13 \| 5:00PM - 7:00PM Combinatorial Readout of Histone PTMs Room: Matterhorn Ballroom Speaker 3 of 5 Or P. Gozani, Stanford University, USA Role of NSD2/MMSET in Chromatin Regulation and Oncogenic Programming
Thursday, January 13 \| 5:00PM - 7:00PM Combinatorial Readout of Histone PTMs Room: Matterhorn Ballroom Speaker 4 of 5 Tatiana G. Kutateladze, University of Colorado School of Medicine, USA Structural Insights into Histone Code Recognition by PHD Fingers
Thursday, January 13 \| 5:00PM - 7:00PM Combinatorial Readout of Histone PTMs Room: Matterhorn Ballroom Speaker 5 of 5 Brian D. Strahl, University of North Carolina at Chapel Hill, USA Short Talk: Targeting the Histone Code Hypothesis via Peptide Arrays
Thursday, January 13 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Bernese Event Center
Thursday, January 13 \| 7:30PM - 10:00PM Poster Session 3 Room: Bernese Event Center
Friday, January 14 \| 6:30AM - 8:00AM Breakfast Room: Bernese Event Center
Friday, January 14 \| 8:00AM - 11:15AM Dynamics of Histone Modifications and Chromosomal Organizati on Room: Matterhorn Ballroom Discuss how responsive the epigenetic process is and how we need to think in three dimensional terms when considering the interplay in the nuclear environment that ultimately decides which gene will be fired up. This will be important to consider as ChIP, ChIP-seq or any other high powered ChIP protocol is dealing with averaging information from multiple alleles (in the case of cancer cells) and lots of cells. This illustrates the limitation of our current approaches and how we are missing the richness and diversity of how each cell configures both or single alleles. Speaker 1 of 7 * Nicole J. Francis, Institut de Recherches Cliniques de Montreal, Canada
Friday, January 14 \| 8:00AM - 11:15AM Dynamics of Histone Modifications and Chromosomal Organizati on Room: Matterhorn Ballroom Discuss how responsive the epigenetic process is and how we need to think in three dimensional terms when considering the interplay in the nuclear environment that ultimately decides which gene will be fired up. This will be important to consider as ChIP, ChIP-seq or any other high powered ChIP protocol is dealing with averaging information from multiple alleles (in the case of cancer cells) and lots of cells. This illustrates the limitation of our current approaches and how we are missing the richness and diversity of how each cell configures both or single alleles. Speaker 2 of 7 Yang Shi, Children's Hospital Boston, Harvard Medical School, USA Histone Demethylation
Friday, January 14 \| 8:00AM - 11:15AM Dynamics of Histone Modifications and Chromosomal Organizati on Room: Matterhorn Ballroom Discuss how responsive the epigenetic process is and how we need to think in three dimensional terms when considering the interplay in the nuclear environment that ultimately decides which gene will be fired up. This will be important to consider as ChIP, ChIP-seq or any other high powered ChIP protocol is dealing with averaging information from multiple alleles (in the case of cancer cells) and lots of cells. This illustrates the limitation of our current approaches and how we are missing the richness and diversity of how each cell configures both or single alleles. Speaker 3 of 7 Dimitris Thanos, BIOMEDICAL RESEARCH FOUNDATION ACADEMY OF ATHENS, Greece Mechanisms of Stochastic Gene Expression
Friday, January 14 \| 8:00AM - 11:15AM Dynamics of Histone Modifications and Chromosomal Organizati on Room: Matterhorn Ballroom Discuss how responsive the epigenetic process is and how we need to think in three dimensional terms when considering the interplay in the nuclear environment that ultimately decides which gene will be fired up. This will be important to consider as ChIP, ChIP-seq or any other high powered ChIP protocol is dealing with averaging information from multiple alleles (in the case of cancer cells) and lots of cells. This illustrates the limitation of our current approaches and how we are missing the richness and diversity of how each cell configures both or single alleles. Speaker 4 of 7 Scott D. Briggs, Purdue University, USA Small Protein Motifs Required for Histone Methylation
Friday, January 14 \| 8:00AM - 11:15AM Dynamics of Histone Modifications and Chromosomal Organizati on Room: Matterhorn Ballroom Discuss how responsive the epigenetic process is and how we need to think in three dimensional terms when considering the interplay in the nuclear environment that ultimately decides which gene will be fired up. This will be important to consider as ChIP, ChIP-seq or any other high powered ChIP protocol is dealing with averaging information from multiple alleles (in the case of cancer cells) and lots of cells. This illustrates the limitation of our current approaches and how we are missing the richness and diversity of how each cell configures both or single alleles. Speaker 5 of 7 Paolo Sassone-Corsi, University of California, Irvine, USA Joining the Dots: Epigenetics, Metabolism and the Circadian Clock
Friday, January 14 \| 8:00AM - 11:15AM Dynamics of Histone Modifications and Chromosomal Organizati on Room: Matterhorn Ballroom Discuss how responsive the epigenetic process is and how we need to think in three dimensional terms when considering the interplay in the nuclear environment that ultimately decides which gene will be fired up. This will be important to consider as ChIP, ChIP-seq or any other high powered ChIP protocol is dealing with averaging information from multiple alleles (in the case of cancer cells) and lots of cells. This illustrates the limitation of our current approaches and how we are missing the richness and diversity of how each cell configures both or single alleles. Speaker 6 of 7 William J. Belden, Rutgers, State University of New Jersey, USA Short Talk: Examining the Role of Histone Crosstalk in Circadian Regulated Gene Expression
Friday, January 14 \| 8:00AM - 11:15AM Dynamics of Histone Modifications and Chromosomal Organizati on Room: Matterhorn Ballroom Discuss how responsive the epigenetic process is and how we need to think in three dimensional terms when considering the interplay in the nuclear environment that ultimately decides which gene will be fired up. This will be important to consider as ChIP, ChIP-seq or any other high powered ChIP protocol is dealing with averaging information from multiple alleles (in the case of cancer cells) and lots of cells. This illustrates the limitation of our current approaches and how we are missing the richness and diversity of how each cell configures both or single alleles. Speaker 7 of 7 Ali Shilatifard, Northwestern University, USA Short Talk: Histone H3K79 Methylation as an Epigenetic code for Telomere-Associated Gene Silencing
Friday, January 14 \| 9:20AM - 9:40AM Coffee Break Room: Matterhorn Foyer
Friday, January 14 \| 11:15AM - 11:15AM On Own for Lunch and Recreation
Friday, January 14 \| 2:30PM - 4:30PM Workshop 2: Navigating Epigenetic Landscapes Room: Matterhorn Ballroom Speaker 1 of 8 * Tatiana G. Kutateladze, University of Colorado School of Medicine, USA
Friday, January 14 \| 2:30PM - 4:30PM Workshop 2: Navigating Epigenetic Landscapes Room: Matterhorn Ballroom Speaker 2 of 8 Alf Herzig, Max-Planck Institute for Infection Biology, Germany A Genetic System to Assess Functions of Higher Eukaryote Histones and Histone Modifications in vivo
Friday, January 14 \| 2:30PM - 4:30PM Workshop 2: Navigating Epigenetic Landscapes Room: Matterhorn Ballroom Speaker 3 of 8 Duy P. Nguyen, MRC Laboratory of Molecular Biology, UK Genetically Encoding Post-Translational Modifications in Recombinant Histones
Friday, January 14 \| 2:30PM - 4:30PM Workshop 2: Navigating Epigenetic Landscapes Room: Matterhorn Ballroom Speaker 4 of 8 Shohei Koide, New York University Langone Health, USA Designer Affinity Reagents for Histone Marks
Friday, January 14 \| 2:30PM - 4:30PM Workshop 2: Navigating Epigenetic Landscapes Room: Matterhorn Ballroom Speaker 5 of 8 Peter V. Kharchenko, Harvard Medical School, USA Characterization of D. melanogaster Chromatin Landscape
Friday, January 14 \| 2:30PM - 4:30PM Workshop 2: Navigating Epigenetic Landscapes Room: Matterhorn Ballroom Speaker 6 of 8 Peter J. Brown, University of Toronto, Canada Discovery of Epigenetic Chemical Probes
Friday, January 14 \| 2:30PM - 4:30PM Workshop 2: Navigating Epigenetic Landscapes Room: Matterhorn Ballroom Speaker 7 of 8 Menzies Chen, Illumina, Inc., USA A Systematic Position-Effect Screen for Interrogating Epigenetic-Genetic Interactions
Friday, January 14 \| 2:30PM - 4:30PM Workshop 2: Navigating Epigenetic Landscapes Room: Matterhorn Ballroom Speaker 8 of 8 Paul D. Soloway, Cornell University, USA Single Molecule Chromatin Analysis
Friday, January 14 \| 4:30PM - 5:00PM Coffee Available Room: Matterhorn Foyer
Friday, January 14 \| 5:00PM - 7:00PM Histone Code: Fact or Fiction? - The Debate Room: Matterhorn Ballroom Speaker 1 of 5 * Barbara Panning, University of California, San Francisco, USA
Friday, January 14 \| 5:00PM - 7:00PM Histone Code: Fact or Fiction? - The Debate Room: Matterhorn Ballroom Speaker 2 of 5 * Steven Henikoff, Fred Hutchinson Cancer Research Center, USA
Friday, January 14 \| 5:00PM - 7:00PM Histone Code: Fact or Fiction? - The Debate Room: Matterhorn Ballroom Speaker 3 of 5 * Ali Shilatifard, Northwestern University, USA
Friday, January 14 \| 5:00PM - 7:00PM Histone Code: Fact or Fiction? - The Debate Room: Matterhorn Ballroom Speaker 4 of 5 * Alexander J. Ruthenburg, University of Chicago, USA
Friday, January 14 \| 5:00PM - 7:00PM Histone Code: Fact or Fiction? - The Debate Room: Matterhorn Ballroom Speaker 5 of 5 * Bryan M. Turner, University of Birmingham, UK
Friday, January 14 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Bernese Event Center
Friday, January 14 \| 8:00PM - 11:00PM Entertainment Room: Bernese Event Center
Friday, January 14 \| 8:00PM - 11:00PM Cash Bar Room: Bernese Event Center
Saturday, January 15 \| 10:22AM - 10:22AM Departure *Session Chair †Invited, not yet responded.