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Web Desc
Transmembrane Signaling by GPCRs and Channels
Organizer(s): Oliver P. Ernst and U. Benjamin Kaupp
Date: January 23 - 28, 2011
Location: Sagebrush Inn & Suites, Taos, NM, USA
Sponsored by Takeda Pharmaceutical Company Limited
Summary of Meeting:
Cellular membranes present natural borders for signal transduction between cells and their environment. Nature developed different strategies to enable signals to cross the membrane barrier. The goal of this meeting is to discuss the molecular mechanisms of transmembrane signaling on the basis of three protein classes, i.e. G protein-coupled receptors, ion channels and transporters. Available protein structures together with biophysical and functional approaches will provide guidance to explore similarities and differences of the underlying mechanisms. Exemplified will be receptors and channels as well as proteins with dual or modified functions, such as channelrhodopsin. A comparative view is thought to bring researchers from diverse fields together and to stimulate further development of transmembrane signaling proteins in drug discovery and fighting disease.
Scholarship Deadline: September 23 2010
Discounted Abstract Deadline: September 23 2010
Abstract Deadline: October 25 2010
Discounted Registration Deadline: November 23 2010
We gratefully acknowledge additional support for this conference from:
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:
Heptares Therapeutics Ltd
We gratefully acknowledge the generous grant for this conference provided by:
National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM094985-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
Click here to view more of these organizations
Program
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Sunday, January 23
| 3:00PM - 7:30PM
Registration
Room: Chamisa Lobby
Sunday, January 23
| 6:15PM - 7:15PM
Refreshments
Room: Chamisa Ballroom 2
Sunday, January 23
| 7:15PM - 9:30PM
Welcome and Keynote Session
Room: Chamisa Ballroom 1
Speaker 2 of 2
Francisco Bezanilla
, University of Chicago, USA
From Conductance to Structure
Sunday, January 23
| 7:15PM - 9:30PM
Welcome and Keynote Session
Room: Chamisa Ballroom 1
Speaker 1 of 2
Brian K. Kobilka
, Stanford University School of Medicine, USA
Structure and Dynamics of G Protein Coupled Receptors: Insights From the Human Beta 2 Adrenoceptor
Monday, January 24
| 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros
Monday, January 24
| 8:00AM - 11:15AM
GPCR Structure and Intramolecular Signal Transduction
Room: Chamisa Ballroom 1
Speaker 7 of 7
William P. Clarke
, University of Texas Health Science Center, USA
Short Talk: Functional Selectivity of Ligands at 7-TMs Receptors:
Evidence for Multiple Active Receptor Conformations
Monday, January 24
| 8:00AM - 11:15AM
GPCR Structure and Intramolecular Signal Transduction
Room: Chamisa Ballroom 1
Speaker 6 of 7
Philippe Rondard
, Institut de Génomique Fonctionnelle, France
Short Talk: Intramolecular Signal Transduction in Metabotropic Glutamate Receptors
Monday, January 24
| 8:00AM - 11:15AM
GPCR Structure and Intramolecular Signal Transduction
Room: Chamisa Ballroom 1
Speaker 5 of 7
Fiona H. Marshall
, Heptares Therapeutics Ltd., UK
Stabilization of GPCRs for Structural Studies
Monday, January 24
| 8:00AM - 11:15AM
GPCR Structure and Intramolecular Signal Transduction
Room: Chamisa Ballroom 1
Speaker 4 of 7
Jörg Standfuss
, Paul Scherrer Institut, Switzerland
Short Talk: Crystal Structure of Constitutively Active Rhodopsins: How an Agonist can Activate its GPCR
Monday, January 24
| 8:00AM - 11:15AM
GPCR Structure and Intramolecular Signal Transduction
Room: Chamisa Ballroom 1
Speaker 3 of 7
Steven O. Smith
, Stony Brook University, USA
Activation of Rhodopsin: Insights from Solid-State NMR Spectroscopy
Monday, January 24
| 8:00AM - 11:15AM
GPCR Structure and Intramolecular Signal Transduction
Room: Chamisa Ballroom 1
Speaker 2 of 7
Oliver P. Ernst
, University of Toronto, Canada
Structure and Dynamics of Rhodopsin
Monday, January 24
| 8:00AM - 11:15AM
GPCR Structure and Intramolecular Signal Transduction
Room: Chamisa Ballroom 1
Speaker 1 of 7
* Krzysztof Palczewski
, Case Western Reserve University, USA
Monday, January 24
| 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby
Monday, January 24
| 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2
Monday, January 24
| 11:15AM - 11:15AM
On Own for Lunch and Recreation
Monday, January 24
| 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2
Monday, January 24
| 4:00PM - 4:30PM
Data Blitz Session 1
Room: Chamisa Ballroom 1
Speaker 5 of 5
Ines Claudia Heinrich
, Max Planck Institute of Molecular Physiology, Germany
Signal Transduction in Chemo- and Photoreceptor Arrays
Monday, January 24
| 4:00PM - 4:30PM
Data Blitz Session 1
Room: Chamisa Ballroom 1
Speaker 4 of 5
Moritz Bünemann
, Phillips University Marburg, Germany
Dynamics of Gq Protein Interactions with PLCbeta3 Studied by TIRF Microscopy
Monday, January 24
| 4:00PM - 4:30PM
Data Blitz Session 1
Room: Chamisa Ballroom 1
Speaker 3 of 5
Steve Briddon
, University of Nottingham, UK
Evidence for Pathway-Specific Active Conformations of the Adenosine-A3 Receptor
Monday, January 24
| 4:00PM - 4:30PM
Data Blitz Session 1
Room: Chamisa Ballroom 1
Speaker 2 of 5
Jana Brejchova
, Academy of Sciences of the Czech Republic, Czech Republic
FLIM, TCSPC and Laurdan Generalized Polarization Studies of the Effect of Cholesterol Depletion on Hydrophobic Interior and Polar-Head Group Region of the Cell Membrane
Monday, January 24
| 4:00PM - 4:30PM
Data Blitz Session 1
Room: Chamisa Ballroom 1
Speaker 1 of 5
Sviatoslav N. Bagriantsev
, University of California, San Francisco, USA
Protons, Heat, and Mechanical Force Converge to Gate Two-Pore Potassium Channels
Monday, January 24
| 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby
Monday, January 24
| 5:00PM - 7:00PM
Interaction of GPCRs with Signaling Proteins
Room: Chamisa Ballroom 1
Speaker 2 of 6
Wayne L. Hubbell
, University of California, Los Angeles, USA
Structural and Dynamical Orgins of G Protein Activation as Revealed by Site Directed Spin Labeling
Monday, January 24
| 5:00PM - 7:00PM
Interaction of GPCRs with Signaling Proteins
Room: Chamisa Ballroom 1
Speaker 1 of 6
*
Thomas P. Sakmar
, Rockefeller University, USA
Monday, January 24
| 5:00PM - 7:00PM
Interaction of GPCRs with Signaling Proteins
Room: Chamisa Ballroom 1
Speaker 3 of 6
Vsevolod V. Gurevich
, Vanderbilt University, USA
Structural Determinants of Receptor Binding and the Conformation of Active Receptor-Bound Arrestin
Monday, January 24
| 5:00PM - 7:00PM
Interaction of GPCRs with Signaling Proteins
Room: Chamisa Ballroom 1
Speaker 4 of 6
John J.G. Tesmer
, University of Michigan, USA
Molecular Basis for the Activation of G Protein-Coupled Receptor Kinases by GPCRs
Monday, January 24
| 5:00PM - 7:00PM
Interaction of GPCRs with Signaling Proteins
Room: Chamisa Ballroom 1
Speaker 5 of 6
Oleg G. Kisselev
, St. Louis University, USA
Short Talk: Role of Transducin beta-gamma Complex in Rod Phototransduction Pathway
Monday, January 24
| 5:00PM - 7:00PM
Interaction of GPCRs with Signaling Proteins
Room: Chamisa Ballroom 1
Speaker 6 of 6
Daniel Fourmy
, INSERM U858, France
Short Talk: A Unique Conformation of the CCK2R Recruits beta-Arrestin2
Monday, January 24
| 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2
Monday, January 24
| 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa Ballroom 2
Tuesday, January 25
| 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros
Tuesday, January 25
| 8:00AM - 11:00AM
Signal Transduction by Microbial Rhodopsins
Room: Chamisa Ballroom 1
Speaker 1 of 5
* † Ulrike Alexiev
, Freie Universitaet Berlin, Germany
Tuesday, January 25
| 8:00AM - 11:00AM
Signal Transduction by Microbial Rhodopsins
Room: Chamisa Ballroom 1
Speaker 2 of 5
Martin Engelhard
, Max Planck Institute for Molecular Physiology, Germany
Sensory Rhodopsins: Transmembrane Signal Transfer
Tuesday, January 25
| 8:00AM - 11:00AM
Signal Transduction by Microbial Rhodopsins
Room: Chamisa Ballroom 1
Speaker 3 of 5
Hideki Kandori
, Nagoya Institute of Technology, Japan
Active Internal Waters in Visual and Microbial Rhodopsins
Tuesday, January 25
| 8:00AM - 11:00AM
Signal Transduction by Microbial Rhodopsins
Room: Chamisa Ballroom 1
Speaker 4 of 5
Peter Hegemann
, Humboldt-Universität zu Berlin, Germany
Channelrhodopsin: The Light-Gating Problem
Tuesday, January 25
| 8:00AM - 11:00AM
Signal Transduction by Microbial Rhodopsins
Room: Chamisa Ballroom 1
Speaker 5 of 5
Karl Deisseroth
, Stanford University, USA
Retinal Proteins as Neural State Switches
Tuesday, January 25
| 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby
Tuesday, January 25
| 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2
Tuesday, January 25
| 11:00AM - 11:00AM
On Own for Lunch and Recreation
Tuesday, January 25
| 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2
Tuesday, January 25
| 4:00PM - 4:30PM
Data Blitz Session 2
Room: Chamisa Ballroom 1
Speaker 1 of 5
Gerd Krause
, Leibniz-Institut für Molekulare Pharmakologie, Germany
From Transmembrane Interactions in the Thyroptropin Receptor to General Aspects of Intramolecular Signal Transduction in GPCRs
Tuesday, January 25
| 4:00PM - 4:30PM
Data Blitz Session 2
Room: Chamisa Ballroom 1
Speaker 2 of 5
Christophe J.W. Moreau
, Structural Biology Institute, France
Engineering of GPCR-Ion Channel Fusion Proteins for Direct Characterization of Ligand Binding and Gating Regulation
Tuesday, January 25
| 4:00PM - 4:30PM
Data Blitz Session 2
Room: Chamisa Ballroom 1
Speaker 3 of 5
Sven Schünke
, Institute of Complex Systems, Research Centre Jülich, Germany
Structural Insights into Conformational Changes of a Cyclic Nucleotide-Binding Domain in Solution from a Bacterial CNG Channel (MloK1)
Tuesday, January 25
| 4:00PM - 4:30PM
Data Blitz Session 2
Room: Chamisa Ballroom 1
Speaker 4 of 5
Peter Nollert
, Bio Data Bridges, USA
Expanded Sampling of Membrane Protein Crystallization Experiments with Plugs and Lipid Matrices
Tuesday, January 25
| 4:00PM - 4:30PM
Data Blitz Session 2
Room: Chamisa Ballroom 1
Speaker 5 of 5
Gregory M. Pask
, Vanderbilt University, USA
A Novel Characterization of an Insect Odorant Receptor as an Ion Channel
Tuesday, January 25
| 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby
Tuesday, January 25
| 5:00PM - 7:00PM
Role of Lipids in Transmembrane Signaling
Room: Chamisa Ballroom 1
Speaker 1 of 5
*
Brian K. Kobilka
, Stanford University School of Medicine, USA
Tuesday, January 25
| 5:00PM - 7:00PM
Role of Lipids in Transmembrane Signaling
Room: Chamisa Ballroom 1
Speaker 2 of 5
Roger K. Sunahara
, University of California, San Diego, USA
Structure and Function of the G-Protein Coupled Receptor Cascade
Tuesday, January 25
| 5:00PM - 7:00PM
Role of Lipids in Transmembrane Signaling
Room: Chamisa Ballroom 1
Speaker 3 of 5
Marc Baldus
, Utrecht University, Netherlands
Membrane Protein Structure in a Cellular(-Like) environment
Tuesday, January 25
| 5:00PM - 7:00PM
Role of Lipids in Transmembrane Signaling
Room: Chamisa Ballroom 1
Speaker 4 of 5
Pontus Gourdon
, Aarhus University, Denmark
Crystal Structure of the Copper Pump
Tuesday, January 25
| 5:00PM - 7:00PM
Role of Lipids in Transmembrane Signaling
Room: Chamisa Ballroom 1
Speaker 5 of 5
Vladimir Ladizhansky
, University of Guelph, Canada
Short Talk: Conformation of a Seven-Helical Transmembrane Photosensor in the Lipid Environment
Tuesday, January 25
| 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2
Tuesday, January 25
| 7:30PM - 10:00PM
Poster Session 2
Room: Chamisa Ballroom 2
Wednesday, January 26
| 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros
Wednesday, January 26
| 8:00AM - 11:00AM
Novel Approaches
Room: Chamisa Ballroom 1
Speaker 1 of 7
* Steven O. Smith
, Stony Brook University, USA
Wednesday, January 26
| 8:00AM - 11:00AM
Novel Approaches
Room: Chamisa Ballroom 1
Speaker 2 of 7
Thomas P. Sakmar
, Rockefeller University, USA
Using Genetically Encoded Non-Natural Amino Acids to Examine the GPCR Signalosome
Wednesday, January 26
| 8:00AM - 11:00AM
Novel Approaches
Room: Chamisa Ballroom 1
Speaker 3 of 7
Krzysztof Palczewski
, Case Western Reserve University, USA
Role of Integral Waters in GPCR Activation
Wednesday, January 26
| 8:00AM - 11:00AM
Novel Approaches
Room: Chamisa Ballroom 1
Speaker 4 of 7
Helmut Grubmüller
, Max Planck Institute for Biophysical Chemistry, Germany
Forces and Non-Equilibrium-Dynamics in Biological Macromolecules
Wednesday, January 26
| 8:00AM - 11:00AM
Novel Approaches
Room: Chamisa Ballroom 1
Speaker 5 of 7
Kenneth E. Carlson
, Ironwood Pharmaceuticals, USA
Short Talk: GPCR Ligand Binding Prediction Assessment for CXCR4 and D3 and Implications for Structure based Drug Discovery
Wednesday, January 26
| 8:00AM - 11:00AM
Novel Approaches
Room: Chamisa Ballroom 1
Speaker 6 of 7
Klaus Gawrisch
, NIAAA, National Institutes of Health, USA
Short Talk: Global Fold of Human Peripheral Cannabinoid Receptor CB2 probed by Solid-State 13C,15N-MAS NMR and Molecular Dynamics Simulations
Wednesday, January 26
| 8:00AM - 11:00AM
Novel Approaches
Room: Chamisa Ballroom 1
Speaker 7 of 7
Irina Kufareva
, University of California, San Diego, USA
Short Talk: GPCR Ligand Binding Prediction Assessment for CXCR4 and D3 and Implications for Structure Based Drug Discovery
Wednesday, January 26
| 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby
Wednesday, January 26
| 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2
Wednesday, January 26
| 11:00AM - 11:00AM
On Own for Lunch and Recreation
Wednesday, January 26
| 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2
Wednesday, January 26
| 4:00PM - 4:30PM
Data Blitz Session 3
Room: Chamisa Ballroom 1
Speaker 1 of 5
Steffen Wolf
, Partner Institute for Computational Biology, China
Directional Proton-Transfer in Membrane Proteins Via Protein-Bound Internal Water Molecules: A Proton-Diode
Wednesday, January 26
| 4:00PM - 4:30PM
Data Blitz Session 3
Room: Chamisa Ballroom 1
Speaker 2 of 5
David M. Thal
, Monash Institute of Pharmaceutical Sciences, Australia
Molecular Mechanism of Selectivity Among G Protein-Coupled Receptor Kinase 2 Inhibitors
Wednesday, January 26
| 4:00PM - 4:30PM
Data Blitz Session 3
Room: Chamisa Ballroom 1
Speaker 3 of 5
Kalyan C. Tirupula
, University of Pittsburgh, USA
Role of Conserved Transmembrane Domain Cysteines in Activation of Metabotropic Glutamate Receptor Type 6
Wednesday, January 26
| 4:00PM - 4:30PM
Data Blitz Session 3
Room: Chamisa Ballroom 1
Speaker 4 of 5
Friederike Winkhaus
, Center of Advanced European Studies and Research (CAESAR), Germany
HCN2 Channels: Cyclic Nucleotide Binding and Oligomerization
Wednesday, January 26
| 4:00PM - 4:30PM
Data Blitz Session 3
Room: Chamisa Ballroom 1
Speaker 5 of 5
Elsa Yan
, Yale University, USA
Purification of G-Protein Coupled Receptor Using Nanodiscs
Wednesday, January 26
| 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby
Wednesday, January 26
| 5:00PM - 7:15PM
Late-Breaking News
Room: Chamisa Ballroom 1
Speaker 1 of 6
*
Francisco Bezanilla
, University of Chicago, USA
Wednesday, January 26
| 5:00PM - 7:15PM
Late-Breaking News
Room: Chamisa Ballroom 1
Speaker 2 of 6
Luis G. Cuello
, Texas Tech University Health Science Center, USA
Structural Mechanism of C-Type Inactivation in Potassium Channels
Wednesday, January 26
| 5:00PM - 7:15PM
Late-Breaking News
Room: Chamisa Ballroom 1
Speaker 3 of 6
Vadim Cherezov
, The Scripps Research Institute, USA
New GPCR Structures
Wednesday, January 26
| 5:00PM - 7:15PM
Late-Breaking News
Room: Chamisa Ballroom 1
Speaker 4 of 6
Wayne A. Hendrickson
, Columbia University, USA
Structural Analysis of SLAC1-Family Anion Channel Activity
Wednesday, January 26
| 5:00PM - 7:15PM
Late-Breaking News
Room: Chamisa Ballroom 1
Speaker 5 of 6
Polina V. Lishko
, University of California, San Francisco, USA
Short Talk: Female Sex Hormone Progesterone and Sperm Specific Calcium Channel CatSper: An Intimate Relationship
Wednesday, January 26
| 5:00PM - 7:15PM
Late-Breaking News
Room: Chamisa Ballroom 1
Speaker 6 of 6
Normann Goodwin
, Center of Advanced European Studies and Research (CAESAR), Germany
Short Talk: The Chemoattractant Progesterone Activates CatSper Channels in Human Sperm
Wednesday, January 26
| 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2
Wednesday, January 26
| 7:30PM - 10:00PM
Poster Session 3
Room: Chamisa Ballroom 2
Thursday, January 27
| 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros
Thursday, January 27
| 8:00AM - 11:00AM
Ion Channel Structure and Function
Room: Chamisa Ballroom 1
Speaker 1 of 6
* Wayne A. Hendrickson
, Columbia University, USA
Thursday, January 27
| 8:00AM - 11:00AM
Ion Channel Structure and Function
Room: Chamisa Ballroom 1
Speaker 2 of 6
Leslie B. Vosshall
, Rockefeller University, USA
Structure-Function Analysis of the Insect Odorant Receptors: Odor-Gated Ion Channels Modulated by Insect Repellents
Thursday, January 27
| 8:00AM - 11:00AM
Ion Channel Structure and Function
Room: Chamisa Ballroom 1
Speaker 3 of 6
Uhtaek Oh
, Seoul National University, South Korea
Anoctamin 1, A Cloned Calcium-Activated Chloride Channel and its Physiological Implications
Thursday, January 27
| 8:00AM - 11:00AM
Ion Channel Structure and Function
Room: Chamisa Ballroom 1
Speaker 4 of 6
U. Benjamin Kaupp
, Center of Advanced European Studies and Research (CAESAR), Germany
Novel Cyclic Nucleotide-Gated Channels
Thursday, January 27
| 8:00AM - 11:00AM
Ion Channel Structure and Function
Room: Chamisa Ballroom 1
Speaker 5 of 6
Crina M. Nimigean
, Weill Cornell Medical College, USA
Mechanism of Proton Sensing in KcsA Potassium Channels
Thursday, January 27
| 8:00AM - 11:00AM
Ion Channel Structure and Function
Room: Chamisa Ballroom 1
Speaker 6 of 6
Elena O. Gracheva
, Yale University School of Medicine, USA
Short Talk: Molecular Basis of Infrared Sensation by Snakes
Thursday, January 27
| 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby
Thursday, January 27
| 11:00AM - 11:00AM
On Own for Lunch and Recreation
Thursday, January 27
| 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby
Thursday, January 27
| 5:00PM - 7:00PM
Mechanisms of Channels and Transporters
Room: Chamisa Ballroom 1
Speaker 1 of 5
* Crina M. Nimigean
, Weill Cornell Medical College, USA
Thursday, January 27
| 5:00PM - 7:00PM
Mechanisms of Channels and Transporters
Room: Chamisa Ballroom 1
Speaker 2 of 5
Pierre-Jean Corringer
, Institut Pasteur - CNRS, France
Allosteric Transition and Regulation of Bacterial Pentameric Channel- Receptors
Thursday, January 27
| 5:00PM - 7:00PM
Mechanisms of Channels and Transporters
Room: Chamisa Ballroom 1
Speaker 3 of 5
Hassane S. Mchaourab
, Vanderbilt University, USA
Structural Dynamics of the Leucine Transporter: Spin Labeling and EPR Spectroscopy
Thursday, January 27
| 5:00PM - 7:00PM
Mechanisms of Channels and Transporters
Room: Chamisa Ballroom 1
Speaker 4 of 5
Olga Boudker
, Weill Cornell Medical College, USA
Conformational Ensemble and Molecular Mechanism of Glutamate Transporters
Thursday, January 27
| 5:00PM - 7:00PM
Mechanisms of Channels and Transporters
Room: Chamisa Ballroom 1
Speaker 5 of 5
Eitan Reuveny
, Weizmann Institute of Science, Israel
Short Talk: Nonenzymatic Rapid Control of GIRK Channel Function by a G Protein-Coupled Receptor Kinase
Thursday, January 27
| 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2
Thursday, January 27
| 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom 2
Thursday, January 27
| 8:00PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom 2
Friday, January 28
| 10:25AM - 10:25AM
Departure
*Session Chair.
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