Web Desc
Genomic Instability and DNA Repair
Organizer(s): Junjie Chen, Karlene A. Cimprich and Michael B. Yaffe
Date: January 30 - February 04, 2011
Location: Keystone Resort, Keystone, CO, USA
Supported by the Directors' Fund
Summary of Meeting:
The maintenance of genomic integrity following DNA damage depends on the coordination of DNA repair, cell cycle progression, transcriptional and post-transcriptional regulation and apoptosis. The integrity of the DNA damage response pathways plays a critical role in human health. This meeting will present the most recent advances in the field and reveal how a complex network of signaling transduction pathways are involved in DNA damage response. The topics include early detection of DNA lesions, DNA damage checkpoint control, DNA repair, genotoxic damage in cancer stem cells, modulation of DNA damage signaling by microRNAs, systems biology approaches to DNA damage and the use of cutting edge technologies in the study of DNA damage responses.
Scholarship Deadline: September 30 2010
Discounted Abstract Deadline: September 30 2010
Abstract Deadline: November 2 2010
Discounted Registration Deadline: November 30 2010
We gratefully acknowledge additional support for this conference from:
BioMarin Pharmaceutical Inc.Integrated DNA TechnologiesLandes BioscienceThe Ellison Medical Foundation
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA153403-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 30 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Sunday, January 30 | 6:15PM - 7:15PM
Refreshments
Room: Longs Peak Foyer


Sunday, January 30 | 7:15PM - 9:30PM
Welcome and Keynote Session
Room: Longs/Grays Peak

Speaker 1 of 3
* Junjie Chen, University of Texas MD Anderson Cancer Center, USA

Sunday, January 30 | 7:15PM - 9:30PM
Welcome and Keynote Session
Room: Longs/Grays Peak

Speaker 2 of 3
David M. Livingston, Dana-Farber Cancer Institute, USA
Genomic Instability and Breast Cancer

Sunday, January 30 | 7:15PM - 9:30PM
Welcome and Keynote Session
Room: Longs/Grays Peak

Speaker 3 of 3
Stephen J. Elledge, Harvard Medical School, USA
The DNA Damage Response: Making it Safe to Play with Knives

Monday, January 31 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Monday, January 31 | 8:00AM - 11:15AM
DNA Damage Signaling: Networks and Systems Approaches
Room: Longs/Grays Peak

Speaker 1 of 7
* Stephen J. Elledge, Harvard Medical School, USA

Monday, January 31 | 8:00AM - 11:15AM
DNA Damage Signaling: Networks and Systems Approaches
Room: Longs/Grays Peak

Speaker 2 of 7
Stephen P. Jackson, University of Cambridge, UK
Early Events in DNA Damage Signaling and DNA Repair

Monday, January 31 | 8:00AM - 11:15AM
DNA Damage Signaling: Networks and Systems Approaches
Room: Longs/Grays Peak

Speaker 3 of 7
Yosef Shiloh, Tel Aviv University, Israel
The ATM-Mediated DNA Damage Response: The System and the Pathways

Monday, January 31 | 8:00AM - 11:15AM
DNA Damage Signaling: Networks and Systems Approaches
Room: Longs/Grays Peak

Speaker 4 of 7
Galit Lahav, Harvard Medical School, USA
Temporal Dynamics of Biological Signals

Monday, January 31 | 8:00AM - 11:15AM
DNA Damage Signaling: Networks and Systems Approaches
Room: Longs/Grays Peak

Speaker 5 of 7
Trey Ideker, University of California, San Diego, USA
Widespread Induction of Genetic Networks in Response to DNA Damage

Monday, January 31 | 8:00AM - 11:15AM
DNA Damage Signaling: Networks and Systems Approaches
Room: Longs/Grays Peak

Speaker 6 of 7
Claus Storgaard Sørensen, University of Copenhagen, Denmark
Short Talk: Generation of ssDNA at Stalled DNA Replication Forks is Mediated by hFBH1 Helicase

Monday, January 31 | 8:00AM - 11:15AM
DNA Damage Signaling: Networks and Systems Approaches
Room: Longs/Grays Peak

Speaker 7 of 7
Shunichi Takeda, Kyoto University, Japan
Short Talk: SLX4 Links Fanconi anemia Pathway to Structure Specific Endonucleases, MUS81, SLX1 and XPF in Interstrand Crosslink Repair

Monday, January 31 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, January 31 | 11:15AM - 1:00PM
Poster Setup
Room: Quandary Peak


Monday, January 31 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, January 31 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary Peak


Monday, January 31 | 2:30PM - 4:30PM
Workshop 1: Checkpoint Controls
Room: Longs/Grays Peak

Speaker 1 of 8
* Karlene A. Cimprich, Stanford University, USA

Monday, January 31 | 2:30PM - 4:30PM
Workshop 1: Checkpoint Controls
Room: Longs/Grays Peak

Speaker 2 of 8
James A. Borowiec, New York University School of Medicine, USA
Single Molecule Analysis Demonstrates that RPA Phosphorylation is Necessary for Efficient Fork Movement during Replication Stress

Monday, January 31 | 2:30PM - 4:30PM
Workshop 1: Checkpoint Controls
Room: Longs/Grays Peak

Speaker 3 of 8
Samuel Sidi, Mount Sinai School of Medicine, USA
Chk1 Regulates PIDDosome Assembly and Function after DNA Damage

Monday, January 31 | 2:30PM - 4:30PM
Workshop 1: Checkpoint Controls
Room: Longs/Grays Peak

Speaker 4 of 8
Nathan A. Ellis, University of Illinois, Chicago, USA
BLM SUMOylation Regulates ssDNA Accumulation at Stalled Forks

Monday, January 31 | 2:30PM - 4:30PM
Workshop 1: Checkpoint Controls
Room: Longs/Grays Peak

Speaker 5 of 8
Jen-Wei Huang, Fred Hutchinson Cancer Research Center, USA
The microRNAs, miR-103 and miR-107, Target RAD51D and Regulate Homologous Recombination and Sensitivity to DNA Damaging Agents

Monday, January 31 | 2:30PM - 4:30PM
Workshop 1: Checkpoint Controls
Room: Longs/Grays Peak

Speaker 6 of 8
Susana Gonzalo, Saint Louis University School of Medicine, USA
Nurturing the Genome: Roles for A-type Lamins in Telomere Maintenance and Regulation of Mechanisms of DNA DSBs Repair

Monday, January 31 | 2:30PM - 4:30PM
Workshop 1: Checkpoint Controls
Room: Longs/Grays Peak

Speaker 7 of 8
Sandy Giuliano, INSERM U895 Equipe 1, France
MITF Controls the DNA Damage Response Signaling Pathway and Cellular Senescence

Monday, January 31 | 2:30PM - 4:30PM
Workshop 1: Checkpoint Controls
Room: Longs/Grays Peak

Speaker 8 of 8
Kareem N. Mohni, University of Connecticut Health Center, USA
Herpes Simplex Virus Type 1 Infection Disables ATR Signaling

Monday, January 31 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, January 31 | 5:00PM - 7:00PM
Mechanism of DNA Damage Signaling and DNA Repair
Room: Longs/Grays Peak

Speaker 1 of 5
* Yosef Shiloh, Tel Aviv University, Israel

Monday, January 31 | 5:00PM - 7:00PM
Mechanism of DNA Damage Signaling and DNA Repair
Room: Longs/Grays Peak

Speaker 2 of 5
Simon J. Boulton, Francis Crick Institute, UK
Regulating Recombination at Telomeres

Monday, January 31 | 5:00PM - 7:00PM
Mechanism of DNA Damage Signaling and DNA Repair
Room: Longs/Grays Peak

Speaker 3 of 5
Daniel Durocher, Lunenfeld-Tanenbaum Research Institute, Canada
The Ubiquitous Role of Ubiquitin in DNA Double-Strand Break Signaling and Repair

Monday, January 31 | 5:00PM - 7:00PM
Mechanism of DNA Damage Signaling and DNA Repair
Room: Longs/Grays Peak

Speaker 4 of 5
Junjie Chen, University of Texas MD Anderson Cancer Center, USA
DNA Damage Signaling and DNA Repair

Monday, January 31 | 5:00PM - 7:00PM
Mechanism of DNA Damage Signaling and DNA Repair
Room: Longs/Grays Peak

Speaker 5 of 5
† Xiaohua Wu, The Scripps Research Institute, USA
Short Talk: MRN and CtIP are Important for Processing DNA Ends with Secondary Structures in Mammalian Cells

Monday, January 31 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary Peak


Monday, January 31 | 7:30PM - 10:00PM
Poster Session 1
Room: Quandary Peak


Tuesday, February 01 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Tuesday, February 01 | 8:00AM - 11:15AM
Advance in DNA Damage Response
Room: Longs/Grays Peak

Speaker 1 of 7
* Stephen P. Jackson, University of Cambridge, UK

Tuesday, February 01 | 8:00AM - 11:15AM
Advance in DNA Damage Response
Room: Longs/Grays Peak

Speaker 2 of 7
Alan D. D'Andrea, Dana-Farber Cancer Institute, USA
Regulation of the Fanconi Anemia Pathway by Ubiquitin and SUMO


Tuesday, February 01 | 8:00AM - 11:15AM
Advance in DNA Damage Response
Room: Longs/Grays Peak

Speaker 3 of 7
Ivan Dikic, Goethe University Medical School, Germany
Ubiquitin Signaling in DNA Repair Pathways


Tuesday, February 01 | 8:00AM - 11:15AM
Advance in DNA Damage Response
Room: Longs/Grays Peak

Speaker 4 of 7
Karlene A. Cimprich, Stanford University, USA
Mechanisms for Maintaining Genome Stability at the Replication Fork

Tuesday, February 01 | 8:00AM - 11:15AM
Advance in DNA Damage Response
Room: Longs/Grays Peak

Speaker 5 of 7
John A. Tainer, The Scripps Research Institute, USA
Extreme Allostery, Mre11-Rad50-Nbs1 Conformations, and the Control of Sensing, Signaling, and Effector Responses at DNA Double-Strand Breaks

Tuesday, February 01 | 8:00AM - 11:15AM
Advance in DNA Damage Response
Room: Longs/Grays Peak

Speaker 6 of 7
Zhenkun Lou, Mayo Clinic, USA
Short Talk: Histone Methyltransferase MMSET Regulates Histone H4 Lysine 20 Methylation and 53BP1 Accumulation at DNA Damage Sites

Tuesday, February 01 | 8:00AM - 11:15AM
Advance in DNA Damage Response
Room: Longs/Grays Peak

Speaker 7 of 7
Shaun E. Peterson, Columbia University, USA
Short Talk: Regulation of Chromosomal DSB Resection in Vertebrate S- and M-Phases

Tuesday, February 01 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, February 01 | 11:15AM - 1:00PM
Poster Setup
Room: Quandary Peak


Tuesday, February 01 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, February 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary Peak


Tuesday, February 01 | 2:30PM - 4:30PM
Workshop 2: DNA Repair
Room: Longs/Grays Peak

Speaker 1 of 9
* Junjie Chen, University of Texas MD Anderson Cancer Center, USA

Tuesday, February 01 | 2:30PM - 4:30PM
Workshop 2: DNA Repair
Room: Longs/Grays Peak

Speaker 2 of 9
Sharon B. Cantor, University of Massachusetts Medical School, USA
An Acetylation Switch Modulates BACH1/FANCJ Function in DNA Damage Repair

Tuesday, February 01 | 2:30PM - 4:30PM
Workshop 2: DNA Repair
Room: Longs/Grays Peak

Speaker 3 of 9
Jeremy M. Stark, Beckman Research Institute of the City of Hope, USA
The DNA Damage Response is Important for Faithful End Utilization during NHEJ of Multiple Chromosome Breaks

Tuesday, February 01 | 2:30PM - 4:30PM
Workshop 2: DNA Repair
Room: Longs/Grays Peak

Speaker 4 of 9
Jianyuan Jack Luo, University of Maryland Baltimore, USA
SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA

Tuesday, February 01 | 2:30PM - 4:30PM
Workshop 2: DNA Repair
Room: Longs/Grays Peak

Speaker 5 of 9
Ali Nowrouzi, NCT, Deutsches Krebsforschungszentrum Heidelberg, Germany
Genome–Wide Detection of DNA Double Strand Breaks (DSB)
at Single Nucleotide Resolution


Tuesday, February 01 | 2:30PM - 4:30PM
Workshop 2: DNA Repair
Room: Longs/Grays Peak

Speaker 6 of 9
Lisa Postow, Rockefeller University, USA
Ubiquitylation of DNA-Bound Ku80 by the SCF Complex

Tuesday, February 01 | 2:30PM - 4:30PM
Workshop 2: DNA Repair
Room: Longs/Grays Peak

Speaker 7 of 9
Ralph Scully, Beth Israel Deaconess Medical Center, USA
Real Time Imaging of the Mammalian Double Strand Break Response

Tuesday, February 01 | 2:30PM - 4:30PM
Workshop 2: DNA Repair
Room: Longs/Grays Peak

Speaker 8 of 9
Wojciech Piwko, Swiss Federal Institute of Technology, ETH Zurich, Switzerland
Identification of the Mms22L – Nfkbil2 Complex as a Novel Regulator of DNA Replication in Human Cells

Tuesday, February 01 | 2:30PM - 4:30PM
Workshop 2: DNA Repair
Room: Longs/Grays Peak

Speaker 9 of 9
Junran Zhang, Ohio State University, USA
A Dual Role of BRCA1 in Two Distinct Homologous Recombination Mediated Repairs in Response to Replication Arrest

Tuesday, February 01 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, February 01 | 5:00PM - 7:00PM
DNA Repair, Stem Cells, Senescence and Aging. Session Spons
ored by The Ellison Medical Foundation.

Room: Longs/Grays Peak

Speaker 1 of 5
* Laura J. Niedernhofer, The Scripps Research Institute, USA

Tuesday, February 01 | 5:00PM - 7:00PM
DNA Repair, Stem Cells, Senescence and Aging. Session Spons
ored by The Ellison Medical Foundation.

Room: Longs/Grays Peak

Speaker 2 of 5
Michael F. Clarke, Stanford University, USA
Effects of Genomic Instability on the Epigenetic and Transcriptional Programs of Breast Cancer Cells

Tuesday, February 01 | 5:00PM - 7:00PM
DNA Repair, Stem Cells, Senescence and Aging. Session Spons
ored by The Ellison Medical Foundation.

Room: Longs/Grays Peak

Speaker 3 of 5
David A. Sinclair, Harvard Medical School, USA
DNA Damage as a Trigger for the Relocalization of Chromatin Factors during Aging and the Role of Fluctuating NAD+

Tuesday, February 01 | 5:00PM - 7:00PM
DNA Repair, Stem Cells, Senescence and Aging. Session Spons
ored by The Ellison Medical Foundation.

Room: Longs/Grays Peak

Speaker 4 of 5
Judith Campisi, Buck Institute for Research on Aging, USA
Genome Maintenance, Aging and Cancer

Tuesday, February 01 | 5:00PM - 7:00PM
DNA Repair, Stem Cells, Senescence and Aging. Session Spons
ored by The Ellison Medical Foundation.

Room: Longs/Grays Peak

Speaker 5 of 5
Joris Pothof, Erasmus MC, Netherlands
Short Talk: MicroRNAs and the DNA Damage Response

Tuesday, February 01 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary Peak


Tuesday, February 01 | 7:30PM - 10:00PM
Poster Session 2
Room: Quandary Peak


Wednesday, February 02 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Wednesday, February 02 | 8:00AM - 11:15AM
Models of DNA Damage Repair and Therapy
Room: Longs/Grays Peak

Speaker 1 of 7
* Michael B. Kastan, St. Jude Children's Research Hospital, USA

Wednesday, February 02 | 8:00AM - 11:15AM
Models of DNA Damage Repair and Therapy
Room: Longs/Grays Peak

Speaker 2 of 7
André Nussenzweig, NCI, National Institutes of Health, USA
Mechanisms of DNA Damage Detection and Repair in Lymphocytes

Wednesday, February 02 | 8:00AM - 11:15AM
Models of DNA Damage Repair and Therapy
Room: Longs/Grays Peak

Speaker 3 of 7
Michael T. Hemann, Massachusetts Institute of Technology, USA
A Role for the DNA Damage Response in Tumor Cell Survival and Acquired Chemoresistance

Wednesday, February 02 | 8:00AM - 11:15AM
Models of DNA Damage Repair and Therapy
Room: Longs/Grays Peak

Speaker 4 of 7
Maria Jasin, Memorial Sloan Kettering Cancer Center, USA
Homologous Recombination and Chromosomal Translocation

Wednesday, February 02 | 8:00AM - 11:15AM
Models of DNA Damage Repair and Therapy
Room: Longs/Grays Peak

Speaker 5 of 7
Helen Piwnica-Worms, Washington University School of Medicine, USA
Exploiting Cell Cycle Checkpoint Control in Cancer Therapy

Wednesday, February 02 | 8:00AM - 11:15AM
Models of DNA Damage Repair and Therapy
Room: Longs/Grays Peak

Speaker 6 of 7
Anindya Dutta, University of Virginia, USA
Short Talk: CRL4-Cdt2 Ubiquitin Ligase Pathway in the Response to DNA Damage and as a Target for Chemotherapy

Wednesday, February 02 | 8:00AM - 11:15AM
Models of DNA Damage Repair and Therapy
Room: Longs/Grays Peak

Speaker 7 of 7
JoAnn M. Sekiguchi, University of Michigan, USA
Short Talk: Mechanisms Underlying Genome Instability and Aberrant Chromosomal Rearrangements Due to Defective Artemis DNA Nuclease Activity

Wednesday, February 02 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 02 | 11:15AM - 1:00PM
Poster Setup
Room: Quandary Peak


Wednesday, February 02 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, February 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary Peak


Wednesday, February 02 | 2:30PM - 4:30PM
Workshop 3: Study of DNA Damage Response at Organism Level
Room: Longs/Grays Peak

Speaker 1 of 8
* André Nussenzweig, NCI, National Institutes of Health, USA

Wednesday, February 02 | 2:30PM - 4:30PM
Workshop 3: Study of DNA Damage Response at Organism Level
Room: Longs/Grays Peak

Speaker 2 of 8
Olivier J. Becherel, University of Queensland, Australia
The First Setx-/- Mouse Model for Ataxia Oculomotor Apraxia Type 2 (AOA2) Uncovers a Novel Role for Senataxin in Meiotic DNA Repair, Recombination and Germ Cell Maturation

Wednesday, February 02 | 2:30PM - 4:30PM
Workshop 3: Study of DNA Damage Response at Organism Level
Room: Longs/Grays Peak

Speaker 3 of 8
Michael Huen, University of Hong Kong, Hong Kong
Limiting Histone Ubiquitylation Selectively Promotes Homologous Recombination DNA Repair

Wednesday, February 02 | 2:30PM - 4:30PM
Workshop 3: Study of DNA Damage Response at Organism Level
Room: Longs/Grays Peak

Speaker 4 of 8
Janneke E. Jaspers, Netherlands Cancer Institute, Netherlands
Loss of 53BP1 Causes Resistance to PARP Inhibition in BRCA1-Mutated Mouse Mammary Tumors

Wednesday, February 02 | 2:30PM - 4:30PM
Workshop 3: Study of DNA Damage Response at Organism Level
Room: Longs/Grays Peak

Speaker 5 of 8
Stephen Meyn, Hospital for Sick Children, Canada
The Fanconi anemia Pathway Regulates BLM-Dependent Telomeric Recombination and Telomere DNA Synthesis in ALT Human Cells

Wednesday, February 02 | 2:30PM - 4:30PM
Workshop 3: Study of DNA Damage Response at Organism Level
Room: Longs/Grays Peak

Speaker 6 of 8
Tomasz Skorski, Temple University, School of Medicine, USA
Targeting Phosphotyrosine-315 in RAD51 Recombinase to Prevent BCR-ABL1 Oncogenic Kinase –Mediated Unfaithful Homeologous Recombination Repair

Wednesday, February 02 | 2:30PM - 4:30PM
Workshop 3: Study of DNA Damage Response at Organism Level
Room: Longs/Grays Peak

Speaker 7 of 8
Shan Zha, Columbia University Medical Center, USA
XLF Has Functional Redundancy with ATM and H2AX in V(D)J Recombination and Non-homologous DNA End-joining

Wednesday, February 02 | 2:30PM - 4:30PM
Workshop 3: Study of DNA Damage Response at Organism Level
Room: Longs/Grays Peak

Speaker 8 of 8
Chengming (Ben) Zhu, University of Texas MD Anderson Cancer Center, USA
Interplay of DNA Repair Pathway and Tumor Suppressor p53 and its Role in Preventing Tumorigenesis and Aging

Wednesday, February 02 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 02 | 5:00PM - 7:00PM
Expanding Dimensions of Genomic Instability and Cancer Thera
py

Room: Longs/Grays Peak

Speaker 1 of 5
* Michael B. Yaffe, Massachusetts Institute of Technology, USA

Wednesday, February 02 | 5:00PM - 7:00PM
Expanding Dimensions of Genomic Instability and Cancer Thera
py

Room: Longs/Grays Peak

Speaker 2 of 5
Judy Lieberman, Harvard University, USA
miR-34a Mediates the p53 Response

Wednesday, February 02 | 5:00PM - 7:00PM
Expanding Dimensions of Genomic Instability and Cancer Thera
py

Room: Longs/Grays Peak

Speaker 3 of 5
Andrei Thomas-Tikhonenko, Children's Hospital of Philadelphia and University of Pennsylvania, USA
A MicroRNA Component of the Myc-p53 Axis

Wednesday, February 02 | 5:00PM - 7:00PM
Expanding Dimensions of Genomic Instability and Cancer Thera
py

Room: Longs/Grays Peak

Speaker 4 of 5
Laura J. Niedernhofer, The Scripps Research Institute, USA
DNA Repair Protects Against Numerous Age-Related Degenerative Diseases

Wednesday, February 02 | 5:00PM - 7:00PM
Expanding Dimensions of Genomic Instability and Cancer Thera
py

Room: Longs/Grays Peak

Speaker 5 of 5
Xiaochun Yu, University of Michigan, USA
Short Talk: Protein Neddylation Regulates DNA Damage Response

Wednesday, February 02 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary Peak


Wednesday, February 02 | 7:30PM - 10:00PM
Poster Session 3
Room: Quandary Peak


Thursday, February 03 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Thursday, February 03 | 8:00AM - 11:15AM
Posttranslational Regulation and Modifications Involved in D
NA Damage Response

Room: Longs/Grays Peak

Speaker 1 of 7
* Alan D. D'Andrea, Dana-Farber Cancer Institute, USA

Thursday, February 03 | 8:00AM - 11:15AM
Posttranslational Regulation and Modifications Involved in D
NA Damage Response

Room: Longs/Grays Peak

Speaker 2 of 7
Michele Pagano, New York University School of Medicine, USA
Role of SCF Ubiquitin Ligases in the Maintenance of Genomic Stability

Thursday, February 03 | 8:00AM - 11:15AM
Posttranslational Regulation and Modifications Involved in D
NA Damage Response

Room: Longs/Grays Peak

Speaker 3 of 7
Michael B. Yaffe, Massachusetts Institute of Technology, USA
Modular Domains Mediate the Assembly and Function of DNA Damage Signaling Complexes

Thursday, February 03 | 8:00AM - 11:15AM
Posttranslational Regulation and Modifications Involved in D
NA Damage Response

Room: Longs/Grays Peak

Speaker 4 of 7
J. Wade Harper, Harvard Medical School, USA
Genetic and Proteomic Analysis of Damage-Signaling Systems

Thursday, February 03 | 8:00AM - 11:15AM
Posttranslational Regulation and Modifications Involved in D
NA Damage Response

Room: Longs/Grays Peak

Speaker 5 of 7
René H. Medema, Netherlands Cancer Institute, Netherlands
A Phosphoproteomic-Based siRNA Screens Uncovers Novel Regulators of Plk1 and p53 that Control Recovery from a DNA Damage-Induced Arrest

Thursday, February 03 | 8:00AM - 11:15AM
Posttranslational Regulation and Modifications Involved in D
NA Damage Response

Room: Longs/Grays Peak

Speaker 6 of 7
Dipanjan Chowdhury, Dana-Farber Cancer Institute, Harvard Medical School, USA
Short Talk: New Approaches to Study Role of Phosphatases in the DNA Damage Response

Thursday, February 03 | 8:00AM - 11:15AM
Posttranslational Regulation and Modifications Involved in D
NA Damage Response

Room: Longs/Grays Peak

Speaker 7 of 7
Lee Zou, Harvard Medical School, USA
Short Talk: Cell Cycle-Regulated and DNA Damage-Induced Chromatin Alterations by CRL4Cdt2-Mediated Destruction of the Histone Methyltransferase Set8

Thursday, February 03 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, February 03 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Thursday, February 03 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, February 03 | 5:00PM - 7:00PM
Genomic Instability, Cancer and Therapy
Room: Longs/Grays Peak

Speaker 1 of 6
* Michael T. Hemann, Massachusetts Institute of Technology, USA

Thursday, February 03 | 5:00PM - 7:00PM
Genomic Instability, Cancer and Therapy
Room: Longs/Grays Peak

Speaker 2 of 6
Thomas Helleday, Karolinska Institutet, Sweden
Novel Players and Pathways for Restarting Stalled Replication Forks

Thursday, February 03 | 5:00PM - 7:00PM
Genomic Instability, Cancer and Therapy
Room: Longs/Grays Peak

Speaker 3 of 6
Michael B. Kastan, St. Jude Children's Research Hospital, USA
Modulation of ATM and p53 for Clinical Benefit

Thursday, February 03 | 5:00PM - 7:00PM
Genomic Instability, Cancer and Therapy
Room: Longs/Grays Peak

Speaker 4 of 6
Massimo Squatrito, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: 53bp1 is a Haploinsufficient Tumor Suppressor that Protects Glioma Cells from Response to Therapy

Thursday, February 03 | 5:00PM - 7:00PM
Genomic Instability, Cancer and Therapy
Room: Longs/Grays Peak

Speaker 5 of 6
Jac A. Nickoloff, Colorado State University, USA
Short Talk: Neoamphimedine, a Novel Topoisomerase IIalpha Inhibitor, Blocks Metnase-Potentiated DNA Decatenation

Thursday, February 03 | 5:00PM - 7:00PM
Genomic Instability, Cancer and Therapy
Room: Longs/Grays Peak

Speaker 6 of 6
Katharina Schlacher, MD Anderson Cancer Center, USA
Short Talk: BRCA2 Protects Stalled Replication Forks from Nucleolytic Degradation Independent of Homologous Recombination

Thursday, February 03 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary Peak


Thursday, February 03 | 8:00PM - 11:00PM
Entertainment
Room: Quandary Peak


Thursday, February 03 | 8:00PM - 11:00PM
Cash Bar
Room: Quandary Peak


Friday, February 04 | 10:25AM - 10:25AM
Departure


*Session Chair.