Web Desc
Lung Development and Repair
Organizer(s): Brigid L.M. Hogan, Ross Metzger and Edward E. Morrisey
Date: February 06 - 11, 2011
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA
Sponsored by Celgene Corporation
Summary of Meeting:
The lung is a complex three-dimensional organ. Its vital functions depend upon the initial establishment and maintenance of dynamic interactions between multiple tissue types. These include the highly branched system of airway tubes and terminal alveolar sacs, blood and lymphatic vessels, nerves, smooth muscle and fibroblasts, and cells of the immune system. Defects in these interactions underlie many serious respiratory disorders, both in the neonate and adult. This meeting will highlight recent advances in our understanding of the molecular and cellular processes driving the development of the lung and how its organization is maintained over the long term in the adult, as well as how these mechanisms are perturbed in disease. New ideas and approaches will be catalyzed by examples from other organ systems. The meeting will also address a major goal in lung biology - to identify the progenitor cells that mediate tissue regeneration and repair after damage by environmental factors or disease.
Scholarship Deadline: October 6 2010
Discounted Abstract Deadline: October 6 2010
Abstract Deadline: November 8 2010
Discounted Registration Deadline: December 3 2010
We gratefully acknowledge additional support for this conference from:
Celgene CorporationCell Signaling Technology, Inc.March of Dimes Foundation
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL106827-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 06 | 3:00PM - 8:00PM
Registration
Room: Promenade


Sunday, February 06 | 5:00PM - 5:00PM
SuperBowl shown on the big screen.
Room: Mesa A-B


Sunday, February 06 | 6:15PM - 7:15PM
Refreshments
Room: Promenade


Sunday, February 06 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Mesa A-B

Speaker 2 of 2
Mark A. Krasnow, Stanford University School of Medicine, USA
Clonal Analysis of Lung Development, Maintenance and Cancer

Sunday, February 06 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Mesa A-B

Speaker 1 of 2
* Brigid L. M. Hogan, Duke University Medical Center, USA

Monday, February 07 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Monday, February 07 | 8:00AM - 11:00AM
How It All Begins
Room: Mesa A-B

Speaker 5 of 5
* Lee A. Niswander, University of Colorado Boulder, USA
Lung Branching Morphogenesis Visualized and Coupled with Functional Genomics

Monday, February 07 | 8:00AM - 11:00AM
How It All Begins
Room: Mesa A-B

Speaker 4 of 5
Jörg Heierhorst, St. Vincent's Institute of Medical Research, Australia
Short Talk: The Zn2+-Finger Protein ASCIZ is an Essential Transcriptional Regulator of Pulmonary Organogenesis

Monday, February 07 | 8:00AM - 11:00AM
How It All Begins
Room: Mesa A-B

Speaker 3 of 5
Edward E. Morrisey, University of Pennsylvania, USA
Epigentic Regulation of Lung Development and Regeneration

Monday, February 07 | 8:00AM - 11:00AM
How It All Begins
Room: Mesa A-B

Speaker 2 of 5
Ross J. Metzger, University of California, San Francisco, USA
Genetic Control of Airway Morphogenesis

Monday, February 07 | 8:00AM - 11:00AM
How It All Begins
Room: Mesa A-B

Speaker 1 of 5
Kenneth S. Zaret, University of Pennsylvania, USA
Signaling to Chromatin during Induction of Foregut Organs

Monday, February 07 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Monday, February 07 | 11:00AM - 1:00PM
Poster Setup
Room: Mesa C


Monday, February 07 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Monday, February 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Monday, February 07 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Monday, February 07 | 5:00PM - 7:00PM
Tissue Interactions in Lung and Organ Development
Room: Mesa A-B

Speaker 1 of 5
* Ross J. Metzger, University of California, San Francisco, USA

Monday, February 07 | 5:00PM - 7:00PM
Tissue Interactions in Lung and Organ Development
Room: Mesa A-B

Speaker 2 of 5
Frank Costantini, Columbia University, USA
Control of Branching Morphogenesis during Kidney Development

Monday, February 07 | 5:00PM - 7:00PM
Tissue Interactions in Lung and Organ Development
Room: Mesa A-B

Speaker 3 of 5
Nikolce Gjorevski, Princeton University, USA
Branching Programs in Engineered Tissues

Monday, February 07 | 5:00PM - 7:00PM
Tissue Interactions in Lung and Organ Development
Room: Mesa A-B

Speaker 4 of 5
Gail R. Martin, University of California, San Francisco, USA
A Surprising Role for FGF/Erk1/2 Signaling in Regulating Meiotic Spindle Orientation

Monday, February 07 | 5:00PM - 7:00PM
Tissue Interactions in Lung and Organ Development
Room: Mesa A-B

Speaker 5 of 5
David M. Ornitz, Washington University School of Medicine, USA
Short Talk: Growth Factor Signaling Pathways in Lung Mesenchyme Development

Monday, February 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa/Ortiz


Monday, February 07 | 7:30PM - 10:00PM
Poster Session 1
Room: Mesa C


Tuesday, February 08 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Tuesday, February 08 | 8:00AM - 11:00AM
Progenitor Cells in Lung Development I
Room: Mesa A-B

Speaker 1 of 6
* Gail R. Martin, University of California, San Francisco, USA

Tuesday, February 08 | 8:00AM - 11:00AM
Progenitor Cells in Lung Development I
Room: Mesa A-B

Speaker 2 of 6
Xin Sun, University of California, San Diego, USA
Elucidating the Genetic Network that Controls
the Initiation of the Mammalian Respiratory Lineage


Tuesday, February 08 | 8:00AM - 11:00AM
Progenitor Cells in Lung Development I
Room: Mesa A-B

Speaker 3 of 6
Maya Kumar, Stanford University, USA
Clonal Analysis of Mesenchymal Progenitors in Mouse Lung Development

Tuesday, February 08 | 8:00AM - 11:00AM
Progenitor Cells in Lung Development I
Room: Mesa A-B

Speaker 4 of 6
John M. Shannon, Cincinnati Children's Hospital Medical Center, USA
Short Talk: Specification of Foregut Endodermal Cells to a Lung Fate Occurs Early in Development

Tuesday, February 08 | 8:00AM - 11:00AM
Progenitor Cells in Lung Development I
Room: Mesa A-B

Speaker 5 of 6
Raphael Kopan, University of Cincinnati College of Medicine, USA
Notch Signaling and Lung Progenitors

Tuesday, February 08 | 8:00AM - 11:00AM
Progenitor Cells in Lung Development I
Room: Mesa A-B

Speaker 6 of 6
Christos Samakovlis, Wenner-Gren Institute Stockholm University, Sweden
A Genome-Wide Analysis of Airway Maturation in Drosophila

Tuesday, February 08 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Tuesday, February 08 | 11:00AM - 1:00PM
Poster Setup
Room: Mesa C


Tuesday, February 08 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Tuesday, February 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Tuesday, February 08 | 2:30PM - 4:30PM
Workshop
Room: Mesa A-B

Speaker 1 of 7
* Kenneth S. Zaret, University of Pennsylvania, USA

Tuesday, February 08 | 2:30PM - 4:30PM
Workshop
Room: Mesa A-B

Speaker 2 of 7
* Jeffrey A. Whitsett, Cincinnati Children's Hospital Medical Center, USA

Tuesday, February 08 | 2:30PM - 4:30PM
Workshop
Room: Mesa A-B

Speaker 3 of 7
Mélanie Bilodeau, Hospital for Sick Children, Canada
Tracking Lung Development

Tuesday, February 08 | 2:30PM - 4:30PM
Workshop
Room: Mesa A-B

Speaker 4 of 7
Amy P. Wong, Hospital for Sick Children, Canada
Establishment of CFTR-Expressing Epithelia from Pluripotent Stem Cells

Tuesday, February 08 | 2:30PM - 4:30PM
Workshop
Room: Mesa A-B

Speaker 5 of 7
Michael D. Green, Mount Sinai School of Medicine, USA
Generation of Anterior Foregut Endoderm From Human Embryonic and Induced Pluripotent Stem Cells

Tuesday, February 08 | 2:30PM - 4:30PM
Workshop
Room: Mesa A-B

Speaker 6 of 7
Ulrich Martin, Hannover Medical School, Germany
Differentiation of Murine Embryonic (mESCs) and Induced Pluripotent Stem Cells (miPSCs) into Definitive Endoderm and Airway Epithelial Cells

Tuesday, February 08 | 2:30PM - 4:30PM
Workshop
Room: Mesa A-B

Speaker 7 of 7
Olga G. Chernaya, University of Illinois, Chicago, USA
Isolation and Characterization of Candidate Mouse Lung Epithelial Progenitor Cells

Tuesday, February 08 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Tuesday, February 08 | 5:00PM - 7:00PM
Building Alveoli and the Lung Blood Supply
Room: Mesa A-B

Speaker 1 of 5
* Mark A. Krasnow, Stanford University School of Medicine, USA

Tuesday, February 08 | 5:00PM - 7:00PM
Building Alveoli and the Lung Blood Supply
Room: Mesa A-B

Speaker 2 of 5
M. Celeste Simon, University of Pennsylvania, USA
HIF-2alpha Deletion Promotes Kras-Driven Lung Tumor Development

Tuesday, February 08 | 5:00PM - 7:00PM
Building Alveoli and the Lung Blood Supply
Room: Mesa A-B

Speaker 3 of 5
Holger Gerhardt, Max Delbrück Center for Molecular Medicine, Germany
Mechanisms in Vascular Patterning

Tuesday, February 08 | 5:00PM - 7:00PM
Building Alveoli and the Lung Blood Supply
Room: Mesa A-B

Speaker 4 of 5
William T. Pu, Children's Hospital, Harvard Medical School, USA
More than a Cover: Mesothelium Function in Organ Development and Disease

Tuesday, February 08 | 5:00PM - 7:00PM
Building Alveoli and the Lung Blood Supply
Room: Mesa A-B

Speaker 5 of 5
Ashley N. Hipps, Vanderbilt University Medical Center, USA
Short Talk: NF-kappaB Activation in Fetal Lung Macrophages Disrupts Saccular Airway Formation

Tuesday, February 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa/Ortiz


Tuesday, February 08 | 7:30PM - 10:00PM
Poster Session 2
Room: Mesa C


Wednesday, February 09 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Wednesday, February 09 | 8:00AM - 11:00AM
Establishing and Differentiating Epithelial Lineages
Room: Mesa A-B

Speaker 1 of 6
* Brigid L. M. Hogan, Duke University Medical Center, USA

Wednesday, February 09 | 8:00AM - 11:00AM
Establishing and Differentiating Epithelial Lineages
Room: Mesa A-B

Speaker 2 of 6
John Wallingford, University of Texas at Austin, USA
Planar Cell Polarity in Development and Function of Mucociliary Epithelia

Wednesday, February 09 | 8:00AM - 11:00AM
Establishing and Differentiating Epithelial Lineages
Room: Mesa A-B

Speaker 3 of 6
Wellington V. Cardoso, Columbia University Medical Center, USA
Notch Regulation of Airway Progenitors Cell Fate in Development and Regeneration

Wednesday, February 09 | 8:00AM - 11:00AM
Establishing and Differentiating Epithelial Lineages
Room: Mesa A-B

Speaker 4 of 6
Jeffrey A. Whitsett, Cincinnati Children's Hospital Medical Center, USA
Ttf-1, Spdef and FoxA2 Interact in a Network Regulating Mucus Metaplasia and Innate Immunity

Wednesday, February 09 | 8:00AM - 11:00AM
Establishing and Differentiating Epithelial Lineages
Room: Mesa A-B

Speaker 5 of 6
Liming Pei, Children's Hospital of Philadelphia/University of Pennsylvania, USA
Short Talk: TR Repression Prevents Type I Pneumocyte Associated Respiratory Distress Syndrome

Wednesday, February 09 | 8:00AM - 11:00AM
Establishing and Differentiating Epithelial Lineages
Room: Mesa A-B

Speaker 6 of 6
Timothy J. Cole, Monash University, Australia
Short Talk: Glucocorticoid and Retinoic Acid Signaling during Late Gestation in the Mouse Lung

Wednesday, February 09 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Wednesday, February 09 | 11:15AM - 1:00PM
Poster Setup
Room: Mesa C


Wednesday, February 09 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, February 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Wednesday, February 09 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Wednesday, February 09 | 5:00PM - 7:00PM
Progenitor Cells in Lung Development II
Room: Mesa A-B

Speaker 1 of 5
* Edward E. Morrisey, University of Pennsylvania, USA

Wednesday, February 09 | 5:00PM - 7:00PM
Progenitor Cells in Lung Development II
Room: Mesa A-B

Speaker 2 of 5
Adam Giangreco, University College London, UK
Lung Stem Cells and Lineage Selection in Mammalian Conducting Airways

Wednesday, February 09 | 5:00PM - 7:00PM
Progenitor Cells in Lung Development II
Room: Mesa A-B

Speaker 3 of 5
Barry R. Stripp, Duke University, USA
Defining Epithelial Progenitor Cells for Lung Maintenance and Repair

Wednesday, February 09 | 5:00PM - 7:00PM
Progenitor Cells in Lung Development II
Room: Mesa A-B

Speaker 4 of 5
Saverio Bellusci, University of Southern California, USA
Fibroblast Growth Factor 10 Signaling in Lung Mesenchymal Lineage Formation

Wednesday, February 09 | 5:00PM - 7:00PM
Progenitor Cells in Lung Development II
Room: Mesa A-B

Speaker 5 of 5
Jonathan L. McQualter, University of Melbourne, Australia
Short Talk: Organisation of Epithelial Stem/Progenitor Cells in the Adult Mouse Lung

Wednesday, February 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa/Ortiz


Wednesday, February 09 | 7:30PM - 10:00PM
Poster Session 3
Room: Mesa C


Thursday, February 10 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Thursday, February 10 | 8:00AM - 11:15AM
Lung Injury and Repair
Room: Mesa A-B

Speaker 1 of 7
* Xin Sun, University of California, San Diego, USA

Thursday, February 10 | 8:00AM - 11:15AM
Lung Injury and Repair
Room: Mesa A-B

Speaker 2 of 7
Harold A. Chapman, University of California, San Francisco, USA
Integrin alpha6beta4 Identifies an Adult Distal Lung Epithelial Population with Progenitor Potential in vivo


Thursday, February 10 | 8:00AM - 11:15AM
Lung Injury and Repair
Room: Mesa A-B

Speaker 3 of 7
Dean Sheppard, University of California, San Francisco, USA
Contributions of Integrins to Lung Inflammation, Injury and Repair

Thursday, February 10 | 8:00AM - 11:15AM
Lung Injury and Repair
Room: Mesa A-B

Speaker 4 of 7
Carla F. Kim, Boston Children's Hospital, USA
Stem Cell Approaches to Understand Lung and Injury Repair and Lung Cancers

Thursday, February 10 | 8:00AM - 11:15AM
Lung Injury and Repair
Room: Mesa A-B

Speaker 5 of 7
Brigid L. M. Hogan, Duke University Medical Center, USA
Epithelial Stem Cells in Lung Development, Maintenance and Repair

Thursday, February 10 | 8:00AM - 11:15AM
Lung Injury and Repair
Room: Mesa A-B

Speaker 6 of 7
Marie-Liesse Asselin-Labat, Walter and Eliza Hall Institute, Australia
Short Talk: Paracrine Signals Regulating Stem Cell Function

Thursday, February 10 | 8:00AM - 11:15AM
Lung Injury and Repair
Room: Mesa A-B

Speaker 7 of 7
Catriona Y. Logan, Stanford University, USA
Short Talk: A Cis-Enhancer Region that Functions to Sense Lung Injury and Regulates Wnt Expression

Thursday, February 10 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Thursday, February 10 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Thursday, February 10 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Thursday, February 10 | 5:00PM - 7:00PM
Potential Cellular Therapies: Problems and Prospects?
Room: Mesa A-B

Speaker 1 of 4
* Harold A. Chapman, University of California, San Francisco, USA

Thursday, February 10 | 5:00PM - 7:00PM
Potential Cellular Therapies: Problems and Prospects?
Room: Mesa A-B

Speaker 2 of 4
Michael J. Welsh, University of Iowa, USA
Airway Abnormalities in Pigs with Targeted Disruption of the Gene Encoding CFTR

Thursday, February 10 | 5:00PM - 7:00PM
Potential Cellular Therapies: Problems and Prospects?
Room: Mesa A-B

Speaker 3 of 4
Jayaraj Rajagopal, Massachusetts General Hospital, USA
Airways from Endogenous Stem Cells

Thursday, February 10 | 5:00PM - 7:00PM
Potential Cellular Therapies: Problems and Prospects?
Room: Mesa A-B

Speaker 4 of 4
Darrell N. Kotton, Boston University, USA
Directed Differentiation of Pluripotent Stem Cells into Endodermal Lung Progenitors

Thursday, February 10 | 8:00PM - 9:00PM
Social Hour with Lite Bites
Room: Promenade/Mesa Ballroom


Thursday, February 10 | 8:00PM - 11:00PM
Entertainment
Room: Mesa Ballroom


Thursday, February 10 | 9:00PM - 11:00PM
Cash Bar
Room: Mesa Ballroom


Friday, February 11 | 10:25AM - 10:25AM
Departure


*Session Chair.