Web Desc
Genetics, Immunology and Repair in Multiple Sclerosis
Organizer(s): Wendy B. Macklin, Gavin Giovannoni and Stephen L. Hauser
Date: February 15 - 20, 2011
Location: Sagebrush Inn & Suites, Taos, NM, USA
Sponsored by National Multiple Sclerosis Society and Teva Pharmaceuticals
Summary of Meeting:
Although the specific etiology of Multiple Sclerosis (MS) remains unknown, important insights into the genetics and environmental triggers underlying the disease have been made. This conference will discuss advances in MS genetics, epigenetics and the interaction of genetics with the environment, particularly with vitamin D metabolism and Epstein Barr Virus. There will be a focus on the immunopathogenesis of MS, including pre-active MS lesions, mechanisms of lymphocyte activation, the B cell and trafficking of cells across the blood brain barrier. The application of new imaging methods and therapeutic strategies that target the immune system and promote remyelination will be discussed. The challenge of integrating emerging insights in the basic mechanisms of myelination, autoimmune demyelination, and neurodegeneration with translational science will he discussed. The goal of this meeting is to provide a broad spectrum of MS researchers with a forum to discuss recent advances, and to foster cross-disciplinary interactions and collaborations.
Scholarship Deadline: October 18 2010
Discounted Abstract Deadline: October 18 2010
Abstract Deadline: November 19 2010
Discounted Registration Deadline: December 15 2010
We gratefully acknowledge additional support for this conference from:
Biogen IdecBoehringer Ingelheim Pharmaceuticals, Inc.National Multiple Sclerosis SocietyTeva Pharmaceuticals
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Biogen Idec


Zdenek Hostomsky, Zuzana Hostomsky, with matching gift from Pfizer

Dusanka Skundric
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS073227-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 15 | 3:00PM - 7:30PM
Registration
Room: Chamisa Lobby


Tuesday, February 15 | 6:15PM - 7:15PM
Refreshments
Room: Chamisa Ballroom 2


Tuesday, February 15 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Chamisa Ballroom 1

Speaker 1 of 1
Stephen Sawcer, University of Cambridge, UK
Whole Genome Studies in MS: Past, Present and Future

Wednesday, February 16 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Wednesday, February 16 | 8:00AM - 11:00AM
Genetic Susceptibility in MS
Room: Chamisa Ballroom 1

Speaker 6 of 6
Pierre-Antoine Gourraud, University of California, San Francisco, USA
Aggregation of Genetic Risk Variants in Multiple Sclerosis

Wednesday, February 16 | 8:00AM - 11:00AM
Genetic Susceptibility in MS
Room: Chamisa Ballroom 1

Speaker 5 of 6
Justin Spanier, University of Minnesota, USA
Short Talk: 1,25-Dihydroxyvitamin D3 Suppresses Fatal Progressive Experimental Autoimmune Encephalomyelitis in Interferon-gamma-Null Mice

Wednesday, February 16 | 8:00AM - 11:00AM
Genetic Susceptibility in MS
Room: Chamisa Ballroom 1

Speaker 4 of 6
Linda Ottoboni, Harvard University, USA
Short Talk: Pathways Convergence of Transcriptomic Signatures from Multiple Sclerosis Susceptibility Alleles

Wednesday, February 16 | 8:00AM - 11:00AM
Genetic Susceptibility in MS
Room: Chamisa Ballroom 1

Speaker 3 of 6
Lars Fugger, University of Oxford, UK
Humanized Animal Models for Mutiple Sclerosis

Wednesday, February 16 | 8:00AM - 11:00AM
Genetic Susceptibility in MS
Room: Chamisa Ballroom 1

Speaker 2 of 6
Trevor J. Kilpatrick, University of Melbourne, Australia
Approaches to Identifying and Studying Genes Relevant to Multiple Sclerosis

Wednesday, February 16 | 8:00AM - 11:00AM
Genetic Susceptibility in MS
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Stephen L. Hauser, University of California, San Francisco, USA

Wednesday, February 16 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Wednesday, February 16 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Wednesday, February 16 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, February 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Wednesday, February 16 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Wednesday, February 16 | 5:00PM - 7:00PM
Epidemiology of MS
Room: Chamisa Ballroom 1

Speaker 2 of 5
Francesca Aloisi, Instituto Superior de Sanita, Italy
Epstein Barr Virus Infection in MS Pathogenesis

Wednesday, February 16 | 5:00PM - 7:00PM
Epidemiology of MS
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Gavin Giovannoni, Barts and The London School of Medicine and Dentistry, UK

Wednesday, February 16 | 5:00PM - 7:00PM
Epidemiology of MS
Room: Chamisa Ballroom 1

Speaker 3 of 5
Ute C. Meier, ICMS London, UK
Short Talk: Innate Immune Responses is Innate Immune Activation as a Hallmark of the Active Multiple Sclerosis Lesion

Wednesday, February 16 | 5:00PM - 7:00PM
Epidemiology of MS
Room: Chamisa Ballroom 1

Speaker 4 of 5
Anne-Louise Ponsonby, Murdoch Children's Research Institute, Australia
The Hygiene Hypothesis and the Development of Multiple Sclerosis

Wednesday, February 16 | 5:00PM - 7:00PM
Epidemiology of MS
Room: Chamisa Ballroom 1

Speaker 5 of 5
Bruce Hollis, Medical University of South Carolina, USA
Achieving Adequate Vitamin D Status and its Role in Multiple Sclerosis

Wednesday, February 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Wednesday, February 16 | 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa Ballroom 2


Thursday, February 17 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Thursday, February 17 | 8:00AM - 11:15AM
Updates on Current Therapeutics
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Bibi Bielekova, NIAID, National Institutes of Health, USA

Thursday, February 17 | 8:00AM - 11:15AM
Updates on Current Therapeutics
Room: Chamisa Ballroom 1

Speaker 2 of 6
Gavin Giovannoni, Barts and The London School of Medicine and Dentistry, UK
Emerging Therapies for Multiple Sclerosis

Thursday, February 17 | 8:00AM - 11:15AM
Updates on Current Therapeutics
Room: Chamisa Ballroom 1

Speaker 3 of 6
Alasdair Coles, University of Cambridge, UK
Autoimmunity - Good and Bad - After Alemtuzumab Treatment of Muliple Sclerosis

Thursday, February 17 | 8:00AM - 11:15AM
Updates on Current Therapeutics
Room: Chamisa Ballroom 1

Speaker 4 of 6
Kenneth L. Tyler, University of Colorado School of Medicine, USA
Association of PML with Immunomodulatory MS Therapeutics

Thursday, February 17 | 8:00AM - 11:15AM
Updates on Current Therapeutics
Room: Chamisa Ballroom 1

Speaker 5 of 6
Susan Goelz, USA
JC Virus Pathobiology and PML in Multiple Sclerosis Patients

Thursday, February 17 | 8:00AM - 11:15AM
Updates on Current Therapeutics
Room: Chamisa Ballroom 1

Speaker 6 of 6
Sybil Rose Stacpoole, University of Cambridge, UK
Short Talk: Human Oligodendrocytes from Embyronic Stem Cells – A Valuable Tool and Potential Therapy for Multiple Sclerosis

Thursday, February 17 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Thursday, February 17 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Thursday, February 17 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Thursday, February 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Thursday, February 17 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Thursday, February 17 | 5:00PM - 7:30PM
Role of B Cells in MS
Room: Chamisa Ballroom 1

Speaker 3 of 6
Peter K. Gregersen, Feinstein Institute for Medical Research, USA
Linking Genotype to Phenotype: Examples from Human Autoimmunity

Thursday, February 17 | 5:00PM - 7:30PM
Role of B Cells in MS
Room: Chamisa Ballroom 1

Speaker 2 of 6
Stephen L. Hauser, University of California, San Francisco, USA
Multiple Sclerosis: Current B Cell Therapies in MS

Thursday, February 17 | 5:00PM - 7:30PM
Role of B Cells in MS
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Colleen E. Hayes, University of Wisconsin-Madison, USA

Thursday, February 17 | 5:00PM - 7:30PM
Role of B Cells in MS
Room: Chamisa Ballroom 1

Speaker 4 of 6
Kevin C. O'Connor, Yale School of Medicine, USA
B Cells and Antibodies in the MS CNS

Thursday, February 17 | 5:00PM - 7:30PM
Role of B Cells in MS
Room: Chamisa Ballroom 1

Speaker 5 of 6
Jeffrey Bennett, University of Colorado Denver, USA
The Targets of Cerebrospinal Fluid Oligoclonal Bands in Multiple Sclerosis

Thursday, February 17 | 5:00PM - 7:30PM
Role of B Cells in MS
Room: Chamisa Ballroom 1

Speaker 6 of 6
Emily Pierson, University of Washington, USA
Short Talk: B Cells are Important for the Expansion of T Cells in the CNS during the Induction of EAE

Thursday, February 17 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Thursday, February 17 | 7:30PM - 10:00PM
Poster Session 2
Room: Chamisa Ballroom 2


Friday, February 18 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Friday, February 18 | 8:00AM - 11:15AM
Events at the Blood-Brain Barrier
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Raymond A. Sobel, Stanford University School of Medicine, USA

Friday, February 18 | 8:00AM - 11:15AM
Events at the Blood-Brain Barrier
Room: Chamisa Ballroom 1

Speaker 2 of 7
Richard Daneman, University of California, San Diego, USA
Cellular and Molecular Regulation of Blood-Brain Barrier Regulation during Health and Disease

Friday, February 18 | 8:00AM - 11:15AM
Events at the Blood-Brain Barrier
Room: Chamisa Ballroom 1

Speaker 3 of 7
Britta Engelhardt, Theodor Kocher Institute/Universitat Bern, Switzerland
T Cell Migration into the CNS during Health and Disease: Different Molecular Keys Allow Access to Different CNS Compartments

Friday, February 18 | 8:00AM - 11:15AM
Events at the Blood-Brain Barrier
Room: Chamisa Ballroom 1

Speaker 4 of 7
Piet Stinissen, Hasselt University, Belgium
Short Talk: CX3CR1 Drives CD4+CD28null Cytotoxic T Cells into the Central Nervous System of Patients with MS

Friday, February 18 | 8:00AM - 11:15AM
Events at the Blood-Brain Barrier
Room: Chamisa Ballroom 1

Speaker 5 of 7
Ann M. Ranger, Biogen Idec, USA
Short Talk: The Level of CXCL13 Correlates with a B Cell and Plasma Cell Transcriptionl Signature in the Cerebrospinal Fluid of Secondary Progressive Multiple Sclerosis Patients

Friday, February 18 | 8:00AM - 11:15AM
Events at the Blood-Brain Barrier
Room: Chamisa Ballroom 1

Speaker 6 of 7
Stephen McQuaid, Queen's University Belfast, UK
Tight Junction Abnormalities at Blood Brain Barrier in Multiple Sclerosis

Friday, February 18 | 8:00AM - 11:15AM
Events at the Blood-Brain Barrier
Room: Chamisa Ballroom 1

Speaker 7 of 7
Paula Dore-Duffy, Wayne State University, USA
Microvascular Pericytes: A Source of Adult Stem Cells

Friday, February 18 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Friday, February 18 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Friday, February 18 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Friday, February 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Friday, February 18 | 2:30PM - 4:30PM
Workshop: MS Research: Prospects for Funding and Training

Speaker 1 of 3
Stephen L. Hauser, University of California, San Francisco, USA

Friday, February 18 | 2:30PM - 4:30PM
Workshop: MS Research: Prospects for Funding and Training

Speaker 2 of 3
Richard A. Rudick, Cleveland Clinic Foundation, USA

Friday, February 18 | 2:30PM - 4:30PM
Workshop: MS Research: Prospects for Funding and Training

Speaker 3 of 3
Henry McFarland, NINDS, National Institutes of Health, USA

Friday, February 18 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Friday, February 18 | 5:00PM - 7:00PM
Imaging in MS Diagnosis and Therapeutics
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Henry McFarland, NINDS, National Institutes of Health, USA

Friday, February 18 | 5:00PM - 7:00PM
Imaging in MS Diagnosis and Therapeutics
Room: Chamisa Ballroom 1

Speaker 2 of 5
Sergio E. Baranzini, University of California, San Francisco, USA
Linking Voxel-Based Morphometry with Genetic Variation in MS

Friday, February 18 | 5:00PM - 7:00PM
Imaging in MS Diagnosis and Therapeutics
Room: Chamisa Ballroom 1

Speaker 3 of 5
Elizabeth Fisher, Cleveland Clinic, USA
Short Talk: A Four-Year Longitudinal Study of Cortical Thickness in Multiple Sclerosis

Friday, February 18 | 5:00PM - 7:00PM
Imaging in MS Diagnosis and Therapeutics
Room: Chamisa Ballroom 1

Speaker 4 of 5
Douglas Arnold, Montreal Neurological Hospital and Institute, Canada
Magnetization Transfer Ratio as a Marker of Demyelination and Remyelination in MS

Friday, February 18 | 5:00PM - 7:00PM
Imaging in MS Diagnosis and Therapeutics
Room: Chamisa Ballroom 1

Speaker 5 of 5
Laura J. Balcer, University of Pennsylvania, USA
Optical Coherence Tomography as a Measure of Axonal and Neuronal Loss in MS

Friday, February 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Friday, February 18 | 7:30PM - 10:00PM
Poster Session 3
Room: Chamisa Ballroom 2


Saturday, February 19 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Saturday, February 19 | 8:00AM - 11:15AM
Mechanisms of MS Progression
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Richard A. Rudick, Cleveland Clinic Foundation, USA

Saturday, February 19 | 8:00AM - 11:15AM
Mechanisms of MS Progression
Room: Chamisa Ballroom 1

Speaker 2 of 7
Amit Bar-Or, University of Pennsylvania, USA
Pediatric-Onset MS: A Window into the MS Spectrum

Saturday, February 19 | 8:00AM - 11:15AM
Mechanisms of MS Progression
Room: Chamisa Ballroom 1

Speaker 3 of 7
Selva Baltan, University of Washington, USA
Excitotoxicity and Mitochondrial Dysfunction Lead to Axonal Degeneration

Saturday, February 19 | 8:00AM - 11:15AM
Mechanisms of MS Progression
Room: Chamisa Ballroom 1

Speaker 4 of 7
Bruce D. Trapp, Cleveland Clinic Foundation, Lerner Research Institute, USA
Cortical Remyelination in Multiple Sclerosis: Environment, Not Age, Modulates Cell Replacement in Human Brain


Saturday, February 19 | 8:00AM - 11:15AM
Mechanisms of MS Progression
Room: Chamisa Ballroom 1

Speaker 5 of 7
David Baker, Blizard Institute, Queen Mary University of London, UK
Control of Spasticity using Central Nervous System-Excluded Cannabinoid Receptor Agonists

Saturday, February 19 | 8:00AM - 11:15AM
Mechanisms of MS Progression
Room: Chamisa Ballroom 1

Speaker 6 of 7
Nicole Schaeren-Wiemers, University Hospital Basel, Switzerland
Short Talk: Remyelinated Lesions Express a Distinct Pattern of Genes Involved in Oligodendrocyte Proliferation and Differentiation

Saturday, February 19 | 8:00AM - 11:15AM
Mechanisms of MS Progression
Room: Chamisa Ballroom 1

Speaker 7 of 7
Ranjan Dutta, Lerner Research Institute, Cleveland Clinic, USA
Short Talk: Loss of Myelin Leads to Alteration of a Neuronal MicroRNA in Multiple Sclerosis Hippocampus

Saturday, February 19 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Saturday, February 19 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Saturday, February 19 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Saturday, February 19 | 5:00PM - 7:00PM
Regulation of Remyelination
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Robyn S. Klein, Washington University School of Medicine, USA

Saturday, February 19 | 5:00PM - 7:00PM
Regulation of Remyelination
Room: Chamisa Ballroom 1

Speaker 2 of 5
Wendy B. Macklin, University of Colorado Denver, USA
Signaling Mechanisms Regulating CNS Myelination

Saturday, February 19 | 5:00PM - 7:00PM
Regulation of Remyelination
Room: Chamisa Ballroom 1

Speaker 3 of 5
V. Wee Yong, University of Calgary, Canada
Promoting Remyelination by Reducing an Inhibitory Microenvironment

Saturday, February 19 | 5:00PM - 7:00PM
Regulation of Remyelination
Room: Chamisa Ballroom 1

Speaker 4 of 5
Steve Fancy, University of California, San Francisco, USA
A Therapeutic Target for Repair in Human Newborn Brain Injury and Multiple Sclerosis

Saturday, February 19 | 5:00PM - 7:00PM
Regulation of Remyelination
Room: Chamisa Ballroom 1

Speaker 5 of 5
Danette Nicolay, University of Colorado Denver, USA
Short Talk: Promoting Remyelination of MS Lesions: Where do Fish Fit in?

Saturday, February 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Saturday, February 19 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom 2


Saturday, February 19 | 8:00PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom 2


Sunday, February 20 | 10:25AM - 10:25AM
Departure


*Session Chair.