Past Meeting | Keystone Symposia

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Multiple Sclerosis (2013A1)

Web Desc
Genetics, Immunology and Repair in Multiple Sclerosis Organizer(s): Wendy B. Macklin, Gavin Giovannoni and Stephen L. Hauser Date: February 15 - 20, 2011 Location: Sagebrush Inn & Suites, Taos, NM, USA Sponsored by National Multiple Sclerosis Society and Teva Pharmaceuticals Summary of Meeting: Although the specific etiology of Multiple Sclerosis (MS) remains unknown, important insights into the genetics and environmental triggers underlying the disease have been made. This conference will discuss advances in MS genetics, epigenetics and the interaction of genetics with the environment, particularly with vitamin D metabolism and Epstein Barr Virus. There will be a focus on the immunopathogenesis of MS, including pre-active MS lesions, mechanisms of lymphocyte activation, the B cell and trafficking of cells across the blood brain barrier. The application of new imaging methods and therapeutic strategies that target the immune system and promote remyelination will be discussed. The challenge of integrating emerging insights in the basic mechanisms of myelination, autoimmune demyelination, and neurodegeneration with translational science will he discussed. The goal of this meeting is to provide a broad spectrum of MS researchers with a forum to discuss recent advances, and to foster cross-disciplinary interactions and collaborations. Scholarship Deadline: October 18 2010 Discounted Abstract Deadline: October 18 2010 Abstract Deadline: November 19 2010 Discounted Registration Deadline: December 15 2010 We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Biogen Idec Zdenek Hostomsky, Zuzana Hostomsky, with matching gift from Pfizer Dusanka Skundric We gratefully acknowledge the generous grant for this conference provided by: National Institute of Neurological Disorders and Stroke (NINDS) Grant No. 1R13NS073227-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Genetics, Immunology and Repair in Multiple Sclerosis

Organizer(s): Wendy B. Macklin, Gavin Giovannoni and Stephen L. Hauser

Date: February 15 - 20, 2011
Location: Sagebrush Inn & Suites, Taos, NM, USA

Sponsored by National Multiple Sclerosis Society and Teva Pharmaceuticals

Summary of Meeting:

Although the specific etiology of Multiple Sclerosis (MS) remains unknown, important insights into the genetics and environmental triggers underlying the disease have been made. This conference will discuss advances in MS genetics, epigenetics and the interaction of genetics with the environment, particularly with vitamin D metabolism and Epstein Barr Virus. There will be a focus on the immunopathogenesis of MS, including pre-active MS lesions, mechanisms of lymphocyte activation, the B cell and trafficking of cells across the blood brain barrier. The application of new imaging methods and therapeutic strategies that target the immune system and promote remyelination will be discussed. The challenge of integrating emerging insights in the basic mechanisms of myelination, autoimmune demyelination, and neurodegeneration with translational science will he discussed. The goal of this meeting is to provide a broad spectrum of MS researchers with a forum to discuss recent advances, and to foster cross-disciplinary interactions and collaborations.

Scholarship Deadline: October 18 2010

Discounted Abstract Deadline: October 18 2010

Abstract Deadline: November 19 2010

Discounted Registration Deadline: December 15 2010

We gratefully acknowledge additional support for this conference from:

Boehringer Ingelheim Pharmaceuticals, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Biogen Idec

Zdenek Hostomsky, Zuzana Hostomsky, with matching gift from Pfizer

Dusanka Skundric

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS073227-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Tuesday, February 15 \| 3:00PM - 7:30PM Registration Room: Chamisa Lobby
Tuesday, February 15 \| 6:15PM - 7:15PM Refreshments Room: Chamisa Ballroom 2
Tuesday, February 15 \| 7:15PM - 8:30PM Welcome and Keynote Address Room: Chamisa Ballroom 1 Speaker 1 of 1 Stephen Sawcer, University of Cambridge, UK Whole Genome Studies in MS: Past, Present and Future
Wednesday, February 16 \| 7:00AM - 8:00AM Breakfast Room: Los Vaqueros
Wednesday, February 16 \| 8:00AM - 11:00AM Genetic Susceptibility in MS Room: Chamisa Ballroom 1 Speaker 6 of 6 Pierre-Antoine Gourraud, University of California, San Francisco, USA Aggregation of Genetic Risk Variants in Multiple Sclerosis
Wednesday, February 16 \| 8:00AM - 11:00AM Genetic Susceptibility in MS Room: Chamisa Ballroom 1 Speaker 5 of 6 Justin Spanier, University of Minnesota, USA Short Talk: 1,25-Dihydroxyvitamin D3 Suppresses Fatal Progressive Experimental Autoimmune Encephalomyelitis in Interferon-gamma-Null Mice
Wednesday, February 16 \| 8:00AM - 11:00AM Genetic Susceptibility in MS Room: Chamisa Ballroom 1 Speaker 4 of 6 Linda Ottoboni, Harvard University, USA Short Talk: Pathways Convergence of Transcriptomic Signatures from Multiple Sclerosis Susceptibility Alleles
Wednesday, February 16 \| 8:00AM - 11:00AM Genetic Susceptibility in MS Room: Chamisa Ballroom 1 Speaker 3 of 6 Lars Fugger, University of Oxford, UK Humanized Animal Models for Mutiple Sclerosis
Wednesday, February 16 \| 8:00AM - 11:00AM Genetic Susceptibility in MS Room: Chamisa Ballroom 1 Speaker 2 of 6 Trevor J. Kilpatrick, University of Melbourne, Australia Approaches to Identifying and Studying Genes Relevant to Multiple Sclerosis
Wednesday, February 16 \| 8:00AM - 11:00AM Genetic Susceptibility in MS Room: Chamisa Ballroom 1 Speaker 1 of 6 * Stephen L. Hauser, University of California, San Francisco, USA
Wednesday, February 16 \| 9:20AM - 9:40AM Coffee Break Room: Chamisa Lobby
Wednesday, February 16 \| 11:00AM - 1:00PM Poster Setup Room: Chamisa Ballroom 2
Wednesday, February 16 \| 11:15AM - 11:15AM On Own for Lunch and Recreation
Wednesday, February 16 \| 1:00PM - 10:00PM Poster Viewing Room: Chamisa Ballroom 2
Wednesday, February 16 \| 4:30PM - 5:00PM Coffee Available Room: Chamisa Lobby
Wednesday, February 16 \| 5:00PM - 7:00PM Epidemiology of MS Room: Chamisa Ballroom 1 Speaker 2 of 5 Francesca Aloisi, Instituto Superior de Sanita, Italy Epstein Barr Virus Infection in MS Pathogenesis
Wednesday, February 16 \| 5:00PM - 7:00PM Epidemiology of MS Room: Chamisa Ballroom 1 Speaker 1 of 5 * Gavin Giovannoni, Barts and The London School of Medicine and Dentistry, UK
Wednesday, February 16 \| 5:00PM - 7:00PM Epidemiology of MS Room: Chamisa Ballroom 1 Speaker 3 of 5 Ute C. Meier, ICMS London, UK Short Talk: Innate Immune Responses is Innate Immune Activation as a Hallmark of the Active Multiple Sclerosis Lesion
Wednesday, February 16 \| 5:00PM - 7:00PM Epidemiology of MS Room: Chamisa Ballroom 1 Speaker 4 of 5 Anne-Louise Ponsonby, Murdoch Children's Research Institute, Australia The Hygiene Hypothesis and the Development of Multiple Sclerosis
Wednesday, February 16 \| 5:00PM - 7:00PM Epidemiology of MS Room: Chamisa Ballroom 1 Speaker 5 of 5 Bruce Hollis, Medical University of South Carolina, USA Achieving Adequate Vitamin D Status and its Role in Multiple Sclerosis
Wednesday, February 16 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Chamisa Ballroom 2
Wednesday, February 16 \| 7:30PM - 10:00PM Poster Session 1 Room: Chamisa Ballroom 2
Thursday, February 17 \| 7:00AM - 8:00AM Breakfast Room: Los Vaqueros
Thursday, February 17 \| 8:00AM - 11:15AM Updates on Current Therapeutics Room: Chamisa Ballroom 1 Speaker 1 of 6 * Bibi Bielekova, NIAID, National Institutes of Health, USA
Thursday, February 17 \| 8:00AM - 11:15AM Updates on Current Therapeutics Room: Chamisa Ballroom 1 Speaker 2 of 6 Gavin Giovannoni, Barts and The London School of Medicine and Dentistry, UK Emerging Therapies for Multiple Sclerosis
Thursday, February 17 \| 8:00AM - 11:15AM Updates on Current Therapeutics Room: Chamisa Ballroom 1 Speaker 3 of 6 Alasdair Coles, University of Cambridge, UK Autoimmunity - Good and Bad - After Alemtuzumab Treatment of Muliple Sclerosis
Thursday, February 17 \| 8:00AM - 11:15AM Updates on Current Therapeutics Room: Chamisa Ballroom 1 Speaker 4 of 6 Kenneth L. Tyler, University of Colorado School of Medicine, USA Association of PML with Immunomodulatory MS Therapeutics
Thursday, February 17 \| 8:00AM - 11:15AM Updates on Current Therapeutics Room: Chamisa Ballroom 1 Speaker 5 of 6 Susan Goelz, USA JC Virus Pathobiology and PML in Multiple Sclerosis Patients
Thursday, February 17 \| 8:00AM - 11:15AM Updates on Current Therapeutics Room: Chamisa Ballroom 1 Speaker 6 of 6 Sybil Rose Stacpoole, University of Cambridge, UK Short Talk: Human Oligodendrocytes from Embyronic Stem Cells – A Valuable Tool and Potential Therapy for Multiple Sclerosis
Thursday, February 17 \| 9:20AM - 9:40AM Coffee Break Room: Chamisa Lobby
Thursday, February 17 \| 11:15AM - 1:00PM Poster Setup Room: Chamisa Ballroom 2
Thursday, February 17 \| 11:15AM - 11:15AM On Own for Lunch and Recreation
Thursday, February 17 \| 1:00PM - 10:00PM Poster Viewing Room: Chamisa Ballroom 2
Thursday, February 17 \| 4:30PM - 5:00PM Coffee Available Room: Chamisa Lobby
Thursday, February 17 \| 5:00PM - 7:30PM Role of B Cells in MS Room: Chamisa Ballroom 1 Speaker 3 of 6 Peter K. Gregersen, Feinstein Institute for Medical Research, USA Linking Genotype to Phenotype: Examples from Human Autoimmunity
Thursday, February 17 \| 5:00PM - 7:30PM Role of B Cells in MS Room: Chamisa Ballroom 1 Speaker 2 of 6 Stephen L. Hauser, University of California, San Francisco, USA Multiple Sclerosis: Current B Cell Therapies in MS
Thursday, February 17 \| 5:00PM - 7:30PM Role of B Cells in MS Room: Chamisa Ballroom 1 Speaker 1 of 6 * Colleen E. Hayes, University of Wisconsin-Madison, USA
Thursday, February 17 \| 5:00PM - 7:30PM Role of B Cells in MS Room: Chamisa Ballroom 1 Speaker 4 of 6 Kevin C. O'Connor, Yale School of Medicine, USA B Cells and Antibodies in the MS CNS
Thursday, February 17 \| 5:00PM - 7:30PM Role of B Cells in MS Room: Chamisa Ballroom 1 Speaker 5 of 6 Jeffrey Bennett, University of Colorado Denver, USA The Targets of Cerebrospinal Fluid Oligoclonal Bands in Multiple Sclerosis
Thursday, February 17 \| 5:00PM - 7:30PM Role of B Cells in MS Room: Chamisa Ballroom 1 Speaker 6 of 6 Emily Pierson, University of Washington, USA Short Talk: B Cells are Important for the Expansion of T Cells in the CNS during the Induction of EAE
Thursday, February 17 \| 7:30PM - 8:30PM Social Hour with Lite Bites Room: Chamisa Ballroom 2
Thursday, February 17 \| 7:30PM - 10:00PM Poster Session 2 Room: Chamisa Ballroom 2
Friday, February 18 \| 7:00AM - 8:00AM Breakfast Room: Los Vaqueros
Friday, February 18 \| 8:00AM - 11:15AM Events at the Blood-Brain Barrier Room: Chamisa Ballroom 1 Speaker 1 of 7 * Raymond A. Sobel, Stanford University School of Medicine, USA
Friday, February 18 \| 8:00AM - 11:15AM Events at the Blood-Brain Barrier Room: Chamisa Ballroom 1 Speaker 2 of 7 Richard Daneman, University of California, San Diego, USA Cellular and Molecular Regulation of Blood-Brain Barrier Regulation during Health and Disease
Friday, February 18 \| 8:00AM - 11:15AM Events at the Blood-Brain Barrier Room: Chamisa Ballroom 1 Speaker 3 of 7 Britta Engelhardt, Theodor Kocher Institute/Universitat Bern, Switzerland T Cell Migration into the CNS during Health and Disease: Different Molecular Keys Allow Access to Different CNS Compartments
Friday, February 18 \| 8:00AM - 11:15AM Events at the Blood-Brain Barrier Room: Chamisa Ballroom 1 Speaker 4 of 7 Piet Stinissen, Hasselt University, Belgium Short Talk: CX3CR1 Drives CD4+CD28null Cytotoxic T Cells into the Central Nervous System of Patients with MS
Friday, February 18 \| 8:00AM - 11:15AM Events at the Blood-Brain Barrier Room: Chamisa Ballroom 1 Speaker 5 of 7 Ann M. Ranger, Biogen Idec, USA Short Talk: The Level of CXCL13 Correlates with a B Cell and Plasma Cell Transcriptionl Signature in the Cerebrospinal Fluid of Secondary Progressive Multiple Sclerosis Patients
Friday, February 18 \| 8:00AM - 11:15AM Events at the Blood-Brain Barrier Room: Chamisa Ballroom 1 Speaker 6 of 7 Stephen McQuaid, Queen's University Belfast, UK Tight Junction Abnormalities at Blood Brain Barrier in Multiple Sclerosis
Friday, February 18 \| 8:00AM - 11:15AM Events at the Blood-Brain Barrier Room: Chamisa Ballroom 1 Speaker 7 of 7 Paula Dore-Duffy, Wayne State University, USA Microvascular Pericytes: A Source of Adult Stem Cells
Friday, February 18 \| 9:20AM - 9:40AM Coffee Break Room: Chamisa Lobby
Friday, February 18 \| 11:15AM - 1:00PM Poster Setup Room: Chamisa Ballroom 2
Friday, February 18 \| 11:15AM - 11:15AM On Own for Lunch and Recreation
Friday, February 18 \| 1:00PM - 10:00PM Poster Viewing Room: Chamisa Ballroom 2
Friday, February 18 \| 2:30PM - 4:30PM Workshop: MS Research: Prospects for Funding and Training Speaker 1 of 3 Stephen L. Hauser, University of California, San Francisco, USA
Friday, February 18 \| 2:30PM - 4:30PM Workshop: MS Research: Prospects for Funding and Training Speaker 2 of 3 Richard A. Rudick, Cleveland Clinic Foundation, USA
Friday, February 18 \| 2:30PM - 4:30PM Workshop: MS Research: Prospects for Funding and Training Speaker 3 of 3 Henry McFarland, NINDS, National Institutes of Health, USA
Friday, February 18 \| 4:30PM - 5:00PM Coffee Available Room: Chamisa Lobby
Friday, February 18 \| 5:00PM - 7:00PM Imaging in MS Diagnosis and Therapeutics Room: Chamisa Ballroom 1 Speaker 1 of 5 * Henry McFarland, NINDS, National Institutes of Health, USA
Friday, February 18 \| 5:00PM - 7:00PM Imaging in MS Diagnosis and Therapeutics Room: Chamisa Ballroom 1 Speaker 2 of 5 Sergio E. Baranzini, University of California, San Francisco, USA Linking Voxel-Based Morphometry with Genetic Variation in MS
Friday, February 18 \| 5:00PM - 7:00PM Imaging in MS Diagnosis and Therapeutics Room: Chamisa Ballroom 1 Speaker 3 of 5 Elizabeth Fisher, Cleveland Clinic, USA Short Talk: A Four-Year Longitudinal Study of Cortical Thickness in Multiple Sclerosis
Friday, February 18 \| 5:00PM - 7:00PM Imaging in MS Diagnosis and Therapeutics Room: Chamisa Ballroom 1 Speaker 4 of 5 Douglas Arnold, Montreal Neurological Hospital and Institute, Canada Magnetization Transfer Ratio as a Marker of Demyelination and Remyelination in MS
Friday, February 18 \| 5:00PM - 7:00PM Imaging in MS Diagnosis and Therapeutics Room: Chamisa Ballroom 1 Speaker 5 of 5 Laura J. Balcer, University of Pennsylvania, USA Optical Coherence Tomography as a Measure of Axonal and Neuronal Loss in MS
Friday, February 18 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Chamisa Ballroom 2
Friday, February 18 \| 7:30PM - 10:00PM Poster Session 3 Room: Chamisa Ballroom 2
Saturday, February 19 \| 7:00AM - 8:00AM Breakfast Room: Los Vaqueros
Saturday, February 19 \| 8:00AM - 11:15AM Mechanisms of MS Progression Room: Chamisa Ballroom 1 Speaker 1 of 7 * Richard A. Rudick, Cleveland Clinic Foundation, USA
Saturday, February 19 \| 8:00AM - 11:15AM Mechanisms of MS Progression Room: Chamisa Ballroom 1 Speaker 2 of 7 Amit Bar-Or, University of Pennsylvania, USA Pediatric-Onset MS: A Window into the MS Spectrum
Saturday, February 19 \| 8:00AM - 11:15AM Mechanisms of MS Progression Room: Chamisa Ballroom 1 Speaker 3 of 7 Selva Baltan, University of Washington, USA Excitotoxicity and Mitochondrial Dysfunction Lead to Axonal Degeneration
Saturday, February 19 \| 8:00AM - 11:15AM Mechanisms of MS Progression Room: Chamisa Ballroom 1 Speaker 4 of 7 Bruce D. Trapp, Cleveland Clinic Foundation, Lerner Research Institute, USA Cortical Remyelination in Multiple Sclerosis: Environment, Not Age, Modulates Cell Replacement in Human Brain
Saturday, February 19 \| 8:00AM - 11:15AM Mechanisms of MS Progression Room: Chamisa Ballroom 1 Speaker 5 of 7 David Baker, Blizard Institute, Queen Mary University of London, UK Control of Spasticity using Central Nervous System-Excluded Cannabinoid Receptor Agonists
Saturday, February 19 \| 8:00AM - 11:15AM Mechanisms of MS Progression Room: Chamisa Ballroom 1 Speaker 6 of 7 Nicole Schaeren-Wiemers, University Hospital Basel, Switzerland Short Talk: Remyelinated Lesions Express a Distinct Pattern of Genes Involved in Oligodendrocyte Proliferation and Differentiation
Saturday, February 19 \| 8:00AM - 11:15AM Mechanisms of MS Progression Room: Chamisa Ballroom 1 Speaker 7 of 7 Ranjan Dutta, Lerner Research Institute, Cleveland Clinic, USA Short Talk: Loss of Myelin Leads to Alteration of a Neuronal MicroRNA in Multiple Sclerosis Hippocampus
Saturday, February 19 \| 9:20AM - 9:40AM Coffee Break Room: Chamisa Lobby
Saturday, February 19 \| 11:15AM - 11:15AM On Own for Lunch and Recreation
Saturday, February 19 \| 4:30PM - 5:00PM Coffee Available Room: Chamisa Lobby
Saturday, February 19 \| 5:00PM - 7:00PM Regulation of Remyelination Room: Chamisa Ballroom 1 Speaker 1 of 5 * Robyn S. Klein, Washington University School of Medicine, USA
Saturday, February 19 \| 5:00PM - 7:00PM Regulation of Remyelination Room: Chamisa Ballroom 1 Speaker 2 of 5 Wendy B. Macklin, University of Colorado Denver, USA Signaling Mechanisms Regulating CNS Myelination
Saturday, February 19 \| 5:00PM - 7:00PM Regulation of Remyelination Room: Chamisa Ballroom 1 Speaker 3 of 5 V. Wee Yong, University of Calgary, Canada Promoting Remyelination by Reducing an Inhibitory Microenvironment
Saturday, February 19 \| 5:00PM - 7:00PM Regulation of Remyelination Room: Chamisa Ballroom 1 Speaker 4 of 5 Steve Fancy, University of California, San Francisco, USA A Therapeutic Target for Repair in Human Newborn Brain Injury and Multiple Sclerosis
Saturday, February 19 \| 5:00PM - 7:00PM Regulation of Remyelination Room: Chamisa Ballroom 1 Speaker 5 of 5 Danette Nicolay, University of Colorado Denver, USA Short Talk: Promoting Remyelination of MS Lesions: Where do Fish Fit in?
Saturday, February 19 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Chamisa Ballroom 2
Saturday, February 19 \| 8:00PM - 11:00PM Entertainment Room: Chamisa Ballroom 2
Saturday, February 19 \| 8:00PM - 11:00PM Cash Bar Room: Chamisa Ballroom 2
Sunday, February 20 \| 10:25AM - 10:25AM Departure *Session Chair.