Web Desc
New Frontiers at the Interface of Immunity and Glycobiology
Organizer(s): Brian A. Cobb, Gabriel A. Rabinovich and Yvette van Kooyk
Date: March 06 - 11, 2011
Location: Fairmont Chateau Lake Louise, Lake Louise, AB, Canada
Supported by the Directors' Fund
Summary of Meeting:
Carbohydrates are often overlooked in the study of the immune system, yet mounting data show that glycans, whether microbial or host in origin, play central roles in essentially all immune response pathways. Changes in glycosylation of host proteins can lead to autoimmunity, indicate oncogenic transformation, or even promote metastasis. Inflammation can be strongly influenced by carbohydrate binding proteins on immune cells. Selectins play critical roles in cell homing to the site of infection, while glycosylation directly influences cellular development and differentiation. Recent advances also highlight how glycan-mediated antigen recognition by dendritic cells impacts our understanding of the innate immune response, while other findings reveal that glycolipids and bacterial polysaccharides can lead to NKT and T cell activation. The goal of this meeting is to bring together the international “glycoimmunology” community to foster interactions and promote the latest insights into the role of glycans in the immune system.
Scholarship Deadline: November 15 2010
Discounted Abstract Deadline: November 15 2010
Abstract Deadline: December 9 2010
Discounted Registration Deadline: January 6 2011
We gratefully acknowledge additional support for this conference from:
Alberta Innovates - Health Solutions, Funded by the Alberta Heritage Foundation for Medical Research Endowment FundBioMarin Pharmaceutical Inc.
Genentech, Inc.
Mizutani Foundation for Glycoscience
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI094888-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 06 | 3:00PM - 7:30PM
Registration
Room: Alpine Gallery


Sunday, March 06 | 6:15PM - 7:15PM
Refreshments
Room: Heritage Hall


Sunday, March 06 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Mt Temple A/B

Speaker 1 of 1
James C. Paulson, The Scripps Research Institute, USA
Modulating Innate and Adaptive Immune Responses with Glycan Ligands of Siglecs

Monday, March 07 | 7:00AM - 8:00AM
Breakfast
Room: Tom Wilson Dining Room


Monday, March 07 | 8:00AM - 11:15AM
B and T Cell Responses and Recognition
Room: Mt Temple A/B

Speaker 1 of 6
* Brian A. Cobb, Case Western Reserve University School of Medicine, USA
MHCII-Mediated T cell Activation by Bacterial Carbohydrate Antigens

Monday, March 07 | 8:00AM - 11:15AM
B and T Cell Responses and Recognition
Room: Mt Temple A/B

Speaker 2 of 6
Michael B. Brenner, Harvard Medical School, USA
Glycan-Driven Innate Mechanisms Activate CD1d Restricted iNKT Cell Responses
to Fungi and Other Microbes


Monday, March 07 | 8:00AM - 11:15AM
B and T Cell Responses and Recognition
Room: Mt Temple A/B

Speaker 3 of 6
Mitchell Kronenberg, La Jolla Institute for Allergy and Immunology, USA
Recognition of Glycolipids from Pathogenic Microbes by Natural Killer T Cells

Monday, March 07 | 8:00AM - 11:15AM
B and T Cell Responses and Recognition
Room: Mt Temple A/B

Speaker 4 of 6
Linda G. Baum, University of California, Los Angeles, USA
CD45 and CD43 Glycosylation during T Cell Maturation, Activation and Survival

Monday, March 07 | 8:00AM - 11:15AM
B and T Cell Responses and Recognition
Room: Mt Temple A/B

Speaker 5 of 6
María Belén Prados, Universidad Nacional de Río Negro, Argentina
Short Talk: Progesterone Induces a Switch in Oligosaccharyltransferase Isoform Expression: Consequences on IgG N-Glycosylation

Monday, March 07 | 8:00AM - 11:15AM
B and T Cell Responses and Recognition
Room: Mt Temple A/B

Speaker 6 of 6
Nina Salinger, Emory University School of Medicine, USA
Short Talk: Anti-Glycan Responses in Mice to Glycan Antigens from the Parasitic Trematode Schistosoma mansoni

Monday, March 07 | 9:20AM - 9:40AM
Coffee Break
Room: Heritage Hall


Monday, March 07 | 11:15AM - 1:00PM
Poster Setup
Room: Mt Temple C


Monday, March 07 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, March 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Mt Temple C


Monday, March 07 | 4:30PM - 5:00PM
Coffee Available
Room: Heritage Hall


Monday, March 07 | 5:00PM - 7:00PM
Innate Immune Responses and Recognition
Room: Mt Temple A/B

Speaker 1 of 4
* Paul R. Crocker, University of Dundee, UK
CD33-Related Siglecs in Modulation of Inflammatory Responses

Monday, March 07 | 5:00PM - 7:00PM
Innate Immune Responses and Recognition
Room: Mt Temple A/B

Speaker 2 of 4
Jamey D. Marth, Sanford-Burnham Medical Research Institute, USA
Exposure and Sensing of Dangerous Glycans in the Prevention and Pathogenesis of Disease

Monday, March 07 | 5:00PM - 7:00PM
Innate Immune Responses and Recognition
Room: Mt Temple A/B

Speaker 3 of 4
Caetano Reis e Sousa, Francis Crick Institute, UK
Syk-Coupled C-Type Lectins at the Crossroads of Innate and Adaptive Immunity

Monday, March 07 | 5:00PM - 7:00PM
Innate Immune Responses and Recognition
Room: Mt Temple A/B

Speaker 4 of 4
Smanla Tundup, University of Georgia, USA
Short Talk: Immune Regulation in Response to Schistosoma Antigen

Monday, March 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mt Temple C


Monday, March 07 | 7:30PM - 10:00PM
Poster Session 1
Room: Mt Temple C


Tuesday, March 08 | 7:00AM - 8:00AM
Breakfast
Room: Tom Wilson Dining Room


Tuesday, March 08 | 8:00AM - 11:15AM
Cell Communication, Homing and Inflammation
Room: Mt Temple A/B

Speaker 1 of 6
* Yvette van Kooyk, Vrije University Medical Center, Netherlands
Carbohydrate Recognition by Dendritic Cells and Cell Communication

Tuesday, March 08 | 8:00AM - 11:15AM
Cell Communication, Homing and Inflammation
Room: Mt Temple A/B

Speaker 2 of 6
Rodger P. McEver, Oklahoma Medical Research Foundation, USA
Selectin-Glycoconjugate Interactions in Cell Communication

Tuesday, March 08 | 8:00AM - 11:15AM
Cell Communication, Homing and Inflammation
Room: Mt Temple A/B

Speaker 3 of 6
Sachiko Sato, Laval University, Canada
Cytosolic Lectin, Galectin-3 and Innate Immune Response during Infections

Tuesday, March 08 | 8:00AM - 11:15AM
Cell Communication, Homing and Inflammation
Room: Mt Temple A/B

Speaker 4 of 6
Fu-Tong Liu, Academia Sinica, Taiwan
Galectins in Allergic Inflammation

Tuesday, March 08 | 8:00AM - 11:15AM
Cell Communication, Homing and Inflammation
Room: Mt Temple A/B

Speaker 5 of 6
Hiroto Kawashima, University of Shizuoka, Japan
Short Talk: Essential Role of Peripheral Node Addressin in Lymphocyte Homing to Nasal-Associated Lymphoid Tissues and Allergic Immune Responses

Tuesday, March 08 | 8:00AM - 11:15AM
Cell Communication, Homing and Inflammation
Room: Mt Temple A/B

Speaker 6 of 6
Jeffrey C. Nolz, University of Iowa, USA
Short Talk: Memory CD8 Tcell Recruitment through Regulation of Selectin Ligand

Tuesday, March 08 | 9:20AM - 9:40AM
Coffee Break
Room: Heritage Hall


Tuesday, March 08 | 11:15AM - 1:00PM
Poster Setup
Room: Mt Temple C


Tuesday, March 08 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, March 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Mt Temple C


Tuesday, March 08 | 4:30PM - 5:00PM
Coffee Available
Room: Heritage Hall


Tuesday, March 08 | 5:00PM - 7:00PM
Workshop and Panel: High-Throughput Screening in Glycomics o
f the Immune Response
Room: Mt Temple A/B
This workshop and panel will discuss new technologies and techniques to study glycobiology at the 'glycomic' scale. After the invited talks, the audience will join in a roundtable interactive session designed to promote glycomics to understand the immune response and to foster potential collaborations.
Speaker 1 of 3
* Anne Dell, Imperial College London, UK
High Sensitivity Mass Spectrometric Analysis of Glycosylation Patterns

Tuesday, March 08 | 5:00PM - 7:00PM
Workshop and Panel: High-Throughput Screening in Glycomics o
f the Immune Response
Room: Mt Temple A/B
This workshop and panel will discuss new technologies and techniques to study glycobiology at the 'glycomic' scale. After the invited talks, the audience will join in a roundtable interactive session designed to promote glycomics to understand the immune response and to foster potential collaborations.
Speaker 2 of 3
Michael Pierce, CCRC, USA
Application of Glycomic Technologies to Identify Potential Cellular Markers and Investigate Glycan Function

Tuesday, March 08 | 5:00PM - 7:00PM
Workshop and Panel: High-Throughput Screening in Glycomics o
f the Immune Response
Room: Mt Temple A/B
This workshop and panel will discuss new technologies and techniques to study glycobiology at the 'glycomic' scale. After the invited talks, the audience will join in a roundtable interactive session designed to promote glycomics to understand the immune response and to foster potential collaborations.
Speaker 3 of 3
Ten Feizi, Imperial College London, UK
Ligand Discovery for Carbohydrate Recognition Systems

Tuesday, March 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mt Temple C


Tuesday, March 08 | 7:30PM - 10:00PM
Poster Session 2
Room: Mt Temple C


Wednesday, March 09 | 7:00AM - 8:00AM
Breakfast
Room: Tom Wilson Dining Room


Wednesday, March 09 | 8:00AM - 11:15AM
Host-Pathogen Interactions
Room: Mt Temple A/B

Speaker 1 of 6
* Richard Cummings, Emory University, USA
O- and N-Glycosylation Pathways in Host-Pathogen Interactions

Wednesday, March 09 | 8:00AM - 11:15AM
Host-Pathogen Interactions
Room: Mt Temple A/B

Speaker 2 of 6
Stephen M. Beverley, Washington University School of Medicine, USA
The Role of Glycoconjugates in Infectivity and Immune Reponses Against the Protozoan Parasite Leishmania major

Wednesday, March 09 | 8:00AM - 11:15AM
Host-Pathogen Interactions
Room: Mt Temple A/B

Speaker 3 of 6
Gerardo R. Vasta, University of Maryland School of Medicine, USA
C- and F-Type Lectins, and Galectins in Host-Pathogen Interactions

Wednesday, March 09 | 8:00AM - 11:15AM
Host-Pathogen Interactions
Room: Mt Temple A/B

Speaker 4 of 6
Teunis B.H. Geijtenbeek, University of Amsterdam, Netherlands
C-type lectin signaling in immunity and infection

Wednesday, March 09 | 8:00AM - 11:15AM
Host-Pathogen Interactions
Room: Mt Temple A/B

Speaker 5 of 6
Bronwyn M. Gunn, Massachusetts General Hospital, USA
Short Talk: Alphavirus N-Linked Glycan Activation of the Host Complement System Contributes to Virus-Induced Inflammatory Disease

Wednesday, March 09 | 8:00AM - 11:15AM
Host-Pathogen Interactions
Room: Mt Temple A/B

Speaker 6 of 6
Hans Chun-Hung Lin, Academia Sinica, Taiwan
Short Talk: Role for alpha-L-Fucosidase in the Control of
Helicobacter pylori-Infected Gastric Cancer Cells


Wednesday, March 09 | 9:20AM - 9:40AM
Coffee Break
Room: Heritage Hall


Wednesday, March 09 | 11:15AM - 12:00PM
Lunch


Wednesday, March 09 | 12:00PM - 2:00PM
Workshop: Glycobiology and Its Implications for HIV-1 Vaccin
e Design
Room: Mt Temple A/B

Speaker 1 of 4
James Arthos, NIAID, National Institutes of Health, USA
N-Linked Glycosylation Patterns in the gp120 Envelope Protein Impact HIV-1 Transmission

Wednesday, March 09 | 12:00PM - 2:00PM
Workshop: Glycobiology and Its Implications for HIV-1 Vaccin
e Design
Room: Mt Temple A/B

Speaker 2 of 4
Heather Desaire, University of Kansas, USA
Comparative Analysis of Recombinant gp140's, using a Glycosylation Site Specific Approach

Wednesday, March 09 | 12:00PM - 2:00PM
Workshop: Glycobiology and Its Implications for HIV-1 Vaccin
e Design
Room: Mt Temple A/B

Speaker 3 of 4
Chris N. Scanlan, University of Oxford, UK
Antibody Recognition of HIV Carbohydrates as a Template for Vaccine Design

Wednesday, March 09 | 12:00PM - 2:00PM
Workshop: Glycobiology and Its Implications for HIV-1 Vaccin
e Design
Room: Mt Temple A/B

Speaker 4 of 4
Galit Alter, MIT and Harvard University, USA
Differential Antibody Glycosylation as a Mechanism for Longterm Control of HIV

Wednesday, March 09 | 2:00PM - 2:30PM
Coffee Available
Room: Heritage Hall


Wednesday, March 09 | 3:00PM - 5:00PM
Hematopoiesis and Lymphocyte Development
Room: Mt Temple A/B

Speaker 1 of 4
* Pamela Stanley, Albert Einstein College of Medicine, USA
O-Fucose Glycans in Notch Signaling and T Cell Development

Wednesday, March 09 | 3:00PM - 5:00PM
Hematopoiesis and Lymphocyte Development
Room: Mt Temple A/B

Speaker 2 of 4
John B. Lowe, Genentech, Inc., USA
Fucosylation-Dependent Control of Leukocyte Biology

Wednesday, March 09 | 3:00PM - 5:00PM
Hematopoiesis and Lymphocyte Development
Room: Mt Temple A/B

Speaker 3 of 4
Siew Cheng Wong, Singapore Immunology Network, Singapore
Short Talk: Gene Expression Profiling Reveals Differential Expression of Carbohydrate Binding Receptor Proteins by the Three Human Monocyte Subsets

Wednesday, March 09 | 3:00PM - 5:00PM
Hematopoiesis and Lymphocyte Development
Room: Mt Temple A/B

Speaker 4 of 4
Martin K. Wild, Max Planck Institute of Molecular Biomedicine, Germany
Short Talk: A Human Defect in alpha2,3-Sialylation Causing Thrombocytopenia and Reduced Selectin Binding

Wednesday, March 09 | 5:00PM - 5:00PM
On Own for Dinner


Wednesday, March 09 | 5:30PM - 5:30PM
Evening Out in Banff
Optional bus trip for those interested in dining and shopping in the town of Banff. Approximate departure time from Banff is 9:00 PM.

Thursday, March 10 | 7:00AM - 8:00AM
Breakfast
Room: Tom Wilson Dining Room


Thursday, March 10 | 8:00AM - 11:00AM
Autoimmunity and Chronic Inflammation
Room: Mt Temple A/B

Speaker 1 of 5
* Gabriel A. Rabinovich, Instituto de Biologia y Medicina Experimental, Argentina
Tolerogenic Circuits Mediated by Galectin-Glycan Interactions in the Resolution of Autoimmune Inflammation

Thursday, March 10 | 8:00AM - 11:00AM
Autoimmunity and Chronic Inflammation
Room: Mt Temple A/B

Speaker 2 of 5
Rikard Holmdahl, Karolinska Institutet, Sweden
Glycosylation Alterations of Autoantigens in Arthritis

Thursday, March 10 | 8:00AM - 11:00AM
Autoimmunity and Chronic Inflammation
Room: Mt Temple A/B

Speaker 3 of 5
Michael Demetriou, University of California, Irvine, USA
N-Glycan Branching, T Cells and Autoimmunity

Thursday, March 10 | 8:00AM - 11:00AM
Autoimmunity and Chronic Inflammation
Room: Mt Temple A/B

Speaker 4 of 5
Hugh J. Willison, University of Glasgow, UK
Antibody-Glycan Interactions in Neuronal Autoimmunity

Thursday, March 10 | 8:00AM - 11:00AM
Autoimmunity and Chronic Inflammation
Room: Mt Temple A/B

Speaker 5 of 5
George Buchlis, University of Pennsylvania and Children's Hospital of Philadelphia, USA
Short Talk: Intrinsically Hyperactive and Hyperproliferative T Cells in Cmah-/- Mice

Thursday, March 10 | 9:20AM - 9:40AM
Coffee Break
Room: Heritage Hall


Thursday, March 10 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Thursday, March 10 | 4:30PM - 5:00PM
Coffee Available
Room: Heritage Hall


Thursday, March 10 | 5:00PM - 7:00PM
Tumor Immunity
Room: Mt Temple A/B

Speaker 1 of 4
* Minoru Fukuda, Sanford-Burnham Medical Research Institute, USA
Endothelial Heparan Sulfate Controls Chemokine Presentation in the Recruitment of Lymphocytes and Dendritic Cells to Lymph Nodes and Inflammatory Tissues


Thursday, March 10 | 5:00PM - 7:00PM
Tumor Immunity
Room: Mt Temple A/B

Speaker 2 of 4
Olivera J. Finn, University of Pittsburgh School of Medicine, USA
Differential Glycosylation of Self and Abnormal Self Antigens for Immunosurveillance of Premalignant and Malignant Lesions


Thursday, March 10 | 5:00PM - 7:00PM
Tumor Immunity
Room: Mt Temple A/B

Speaker 3 of 4
James W. Dennis, Mount Sinai Hospital, Canada
N-glycan, Metabolism and Tumor Progression

Thursday, March 10 | 5:00PM - 7:00PM
Tumor Immunity
Room: Mt Temple A/B

Speaker 4 of 4
Pierre van der Bruggen, Ludwig Institute for Cancer Research, Belgium
Short Talk: Is it Possible to Correct the Impaired Function of Human Infiltrating Lymphocytes?

Thursday, March 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Victoria


Thursday, March 10 | 8:00PM - 11:00PM
Entertainment
Room: Victoria


Thursday, March 10 | 8:00PM - 11:00PM
Cash Bar
Room: Victoria


Friday, March 11 | 10:25AM - 10:25AM
Departure


*Session Chair.