Web Desc
Environmental Epigenomics and Disease Susceptibility
Organizer(s): Randy L. Jirtle, Moshe Szyf and Frederick L. Tyson
Date: March 27 - April 01, 2011
Location: Grove Park Inn Resort & Spa, Asheville, NC, USA
Supported by the Directors' Fund
Summary of Meeting:
There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs in cells are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this conference is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome. Epigenetic research promises to markedly improve our ability to diagnosis, prevent, and treat the pathological conditions of humans; however, it also introduces unique legal and ethical issues. These will also be discussed.
Scholarship Deadline: November 30 2010
Discounted Abstract Deadline: November 30 2010
Abstract Deadline: December 31 2010
Discounted Registration Deadline: January 28 2011
We gratefully acknowledge additional support for this conference from:
Autism SpeaksMarch of Dimes FoundationRete Mirabile Fund of Triangle Community FoundationSociety of Toxicology
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Portland Press LtdStichting iNSnet
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK084688-02

National Institute of Environmental Health Sciences (NIEHS)
Grant No. 1R13ES020113-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 27 | 3:00PM - 7:30PM
Registration
Room: Vanderbilt


Sunday, March 27 | 6:15PM - 7:15PM
Refreshments
Room: Grand Ballroom B-C


Sunday, March 27 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Grand Ballroom A

Speaker 1 of 1
Eva Jablonka, Tel Aviv University, Israel
Being Fit in Four Dimensions

Monday, March 28 | 7:30AM - 8:30AM
Breakfast
Room: Grand Ballroom B-C


Monday, March 28 | 8:30AM - 11:45AM
Fetal Origins of Adult Disease Susceptibility
Room: Grand Ballroom A

Speaker 1 of 7
* Cathrine Hoyo, Duke University, USA

Monday, March 28 | 8:30AM - 11:45AM
Fetal Origins of Adult Disease Susceptibility
Room: Grand Ballroom A

Speaker 2 of 7
Ezra S. Susser, Columbia University and New York State Psychiatric Institute, USA
Prenatal Famine, Epigenetics, and Schizophrenia

Monday, March 28 | 8:30AM - 11:45AM
Fetal Origins of Adult Disease Susceptibility
Room: Grand Ballroom A

Speaker 3 of 7
Marcus Pembrey, University College London, UK
Nature of Human Transgenerational Responses

Monday, March 28 | 8:30AM - 11:45AM
Fetal Origins of Adult Disease Susceptibility
Room: Grand Ballroom A

Speaker 4 of 7
Gudrun E. Moore, Institute of Child Health, UK
Epigenetic Dysregulation of Imprinting Influences Birth Weight and Disease Susceptibility in Humans

Monday, March 28 | 8:30AM - 11:45AM
Fetal Origins of Adult Disease Susceptibility
Room: Grand Ballroom A

Speaker 5 of 7
Claudine Junien, INRA, France
Nutritional and Metabolic Programming: Sexual Dimorphism Epigenetics

Monday, March 28 | 8:30AM - 11:45AM
Fetal Origins of Adult Disease Susceptibility
Room: Grand Ballroom A

Speaker 6 of 7
Martha Susiarjo, University of Pennsylvania, USA
Short Talk: Effects of Bisphenol A Exposure on Genomic Imprinting in the Mouse

Monday, March 28 | 8:30AM - 11:45AM
Fetal Origins of Adult Disease Susceptibility
Room: Grand Ballroom A

Speaker 7 of 7
Ruijun Han, University of Minnesota, USA
Short Talk: Prenatal Stress Up-Regulates NPY Expression and Leads to Gender-Specific Abdominal Obesity and Glucose Intolerance: Possible Role of Epigenetics

Monday, March 28 | 9:50AM - 10:10AM
Coffee Break
Room: Grand Ballroom B-C


Monday, March 28 | 11:45AM - 1:00PM
Poster Setup
Room: Grand Ballroom B-C


Monday, March 28 | 11:45AM - 11:45AM
On Own for Lunch and Recreation


Monday, March 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Grand Ballroom B-C


Monday, March 28 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Ballroom Foyer


Monday, March 28 | 5:00PM - 7:00PM
Epigenetic Mechanisms of Gene Regulation
Room: Grand Ballroom A

Speaker 1 of 5
* Douglas A. Bell, NIEHS, National Institutes of Health, USA

Monday, March 28 | 5:00PM - 7:00PM
Epigenetic Mechanisms of Gene Regulation
Room: Grand Ballroom A

Speaker 2 of 5
Ian C. Wood, University of Leeds, UK
Chromatin Crosstalk in Development and Disease

Monday, March 28 | 5:00PM - 7:00PM
Epigenetic Mechanisms of Gene Regulation
Room: Grand Ballroom A

Speaker 3 of 5
Joseph R. Ecker, The Salk Institute for Biological Studies, USA
Sequencing the Epigenomes of Plants and People

Monday, March 28 | 5:00PM - 7:00PM
Epigenetic Mechanisms of Gene Regulation
Room: Grand Ballroom A

Speaker 4 of 5
Victor V. Lobanenkov, NIAID, National Institutes of Health, USA
CTCF Dysfunction, Epigenetic Deregulation, and Cancer Susceptibility

Monday, March 28 | 5:00PM - 7:00PM
Epigenetic Mechanisms of Gene Regulation
Room: Grand Ballroom A

Speaker 5 of 5
Sonja J. Prohaska, University of Leipzig, Germany
Short Talk: Analytical Analysis and Modeling of the Dynamic Epigenome

Monday, March 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grand Ballroom B-C


Monday, March 28 | 7:30PM - 10:00PM
Poster Session 1
Room: Grand Ballroom B-C


Tuesday, March 29 | 7:30AM - 8:30AM
Breakfast
Room: Grand Ballroom B-C


Tuesday, March 29 | 8:30AM - 11:45AM
In vitro Fertilization, Cloning and Stem Cells
Room: Grand Ballroom A

Speaker 1 of 6
* J. Richard Chaillet, University of Pittsburgh, USA

Tuesday, March 29 | 8:30AM - 11:45AM
In vitro Fertilization, Cloning and Stem Cells
Room: Grand Ballroom A

Speaker 2 of 6
James A. Thomson, Morgridge Institute for Research, University of Wisconsin, USA
Epigenetic State and Genetic Stability of Human iPS Cells

Tuesday, March 29 | 8:30AM - 11:45AM
In vitro Fertilization, Cloning and Stem Cells
Room: Grand Ballroom A

Speaker 3 of 6
Louise Laurent, University of California, San Diego, USA
The Epigenomics of Human Pluripotent Stem Cells

Tuesday, March 29 | 8:30AM - 11:45AM
In vitro Fertilization, Cloning and Stem Cells
Room: Grand Ballroom A

Speaker 4 of 6
Wolf Reik, Babraham Institute, UK
Mechanisms and Functions of Epigenetic Reprogramming in Mammalian Development

Tuesday, March 29 | 8:30AM - 11:45AM
In vitro Fertilization, Cloning and Stem Cells
Room: Grand Ballroom A

Speaker 5 of 6
Rosanna Weksberg, Hospital for Sick Children, Canada
Short Talk: Increased Frequency of Multilocus Loss of Methylation in Beckwith Wiedemann Syndrome Cases Conceived using Assisted Reproductive Technologies

Tuesday, March 29 | 8:30AM - 11:45AM
In vitro Fertilization, Cloning and Stem Cells
Room: Grand Ballroom A

Speaker 6 of 6
Toshi Shioda, Massachusetts General Hospital, USA
Short Talk: Specific Erasure of the Abnormal Biallelic Hypermethylation at the Gtl2/Meg3 Intragenic DMR in Mouse Induced Pluripotent Stem Cells (iPSCs) during In Vitro Derivation of Germline Cells

Tuesday, March 29 | 9:50AM - 10:10AM
Coffee Break
Room: Grand Ballroom B-C


Tuesday, March 29 | 11:45AM - 1:00PM
Poster Setup
Room: Grand Ballroom B-C


Tuesday, March 29 | 11:45AM - 11:45AM
On Own for Lunch and Recreation


Tuesday, March 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Grand Ballroom B-C


Tuesday, March 29 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Ballroom Foyer


Tuesday, March 29 | 5:00PM - 7:15PM
Postnatal Epigenetic Programming of the Brain
Room: Grand Ballroom A

Speaker 1 of 6
* Ian C.G. Weaver, Centre for Addiction and Mental Health, Canada

Tuesday, March 29 | 5:00PM - 7:15PM
Postnatal Epigenetic Programming of the Brain
Room: Grand Ballroom A

Speaker 2 of 6
Moshe Szyf, McGill University, Canada
Early Life Environment and the Epigenome

Tuesday, March 29 | 5:00PM - 7:15PM
Postnatal Epigenetic Programming of the Brain
Room: Grand Ballroom A

Speaker 3 of 6
Barry Keverne, University of Cambridge, UK
Epigenetics, Maternal Brain Evolution and Behavior

Tuesday, March 29 | 5:00PM - 7:15PM
Postnatal Epigenetic Programming of the Brain
Room: Grand Ballroom A

Speaker 4 of 6
J. David Sweatt, University of Alabama at Birmingham, USA
Epigenetic Mechanisms in Memory Formation

Tuesday, March 29 | 5:00PM - 7:15PM
Postnatal Epigenetic Programming of the Brain
Room: Grand Ballroom A

Speaker 5 of 6
Syed Wasem Bihaqi, University of Rhode Island, USA
Short Talk: Alzheimer’s Disease: Epigenetic Intermediates and Exposure to Pb in an in-vitro Model

Tuesday, March 29 | 5:00PM - 7:15PM
Postnatal Epigenetic Programming of the Brain
Room: Grand Ballroom A

Speaker 6 of 6
Eunah Kim, University of Texas MD Anderson Cancer Center, USA
Short Talk: Altered Chromatin Structure Induced by Hyperexpanded GAA Repeats in Friedreich’s Ataxia

Tuesday, March 29 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Grand Ballroom B-C


Tuesday, March 29 | 7:30PM - 10:00PM
Poster Session 2
Room: Grand Ballroom B-C


Wednesday, March 30 | 7:30AM - 8:30AM
Breakfast
Room: Grand Ballroom B-C


Wednesday, March 30 | 8:30AM - 11:15AM
Epigenetics and Complex Diseases
Room: Grand Ballroom A

Speaker 1 of 7
* Janos Zempleni, University of Nebraska, Lincoln, USA

Wednesday, March 30 | 8:30AM - 11:15AM
Epigenetics and Complex Diseases
Room: Grand Ballroom A

Speaker 2 of 7
Maria Berdasco, IDIBELL, Spain
Human Cancer Epigenetics

Wednesday, March 30 | 8:30AM - 11:15AM
Epigenetics and Complex Diseases
Room: Grand Ballroom A

Speaker 3 of 7
Frederica P. Perera, Columbia University, USA
Prenatal Environmental Exposures to Common Hydrocarbons PAH and BPA

Wednesday, March 30 | 8:30AM - 11:15AM
Epigenetics and Complex Diseases
Room: Grand Ballroom A

Speaker 4 of 7
Dana C. Dolinoy, University of Michigan School of Public Health, USA
Complex Diseases: Epigenetic Manifestation of Environmental Exposures

Wednesday, March 30 | 8:30AM - 11:15AM
Epigenetics and Complex Diseases
Room: Grand Ballroom A

Speaker 5 of 7
Cheryl L. Walker, Baylor College of Medicine, USA
Fetal and Early Postnatal Environmental Exposures and Female Reproductive Health Effects

Wednesday, March 30 | 8:30AM - 11:15AM
Epigenetics and Complex Diseases
Room: Grand Ballroom A

Speaker 6 of 7
Robert Lyle, Oslo University Hospital, Norway
Short Talk: DNA Methylation and Gene Expression in Monozygotic Twins Discordant for Psoriasis

Wednesday, March 30 | 8:30AM - 11:15AM
Epigenetics and Complex Diseases
Room: Grand Ballroom A

Speaker 7 of 7
Carrie V. Breton, University of Southern California, USA
Short Talk: Air Pollution is Associated with DNA Methylation in Inducible Nitric Oxide Synthase

Wednesday, March 30 | 9:50AM - 10:10AM
Coffee Break
Room: Grand Ballroom B-C


Wednesday, March 30 | 11:45AM - 1:00PM
Poster Setup
Room: Grand Ballroom B-C


Wednesday, March 30 | 11:45AM - 11:45AM
On Own for Lunch and Recreation


Wednesday, March 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Grand Ballroom B-C


Wednesday, March 30 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Ballroom Foyer


Wednesday, March 30 | 5:00PM - 7:15PM
Epigenetic Transgenerational Inheritance
Room: Grand Ballroom A

Speaker 1 of 6
* Patrick O. McGowan, University of Toronto, Canada

Wednesday, March 30 | 5:00PM - 7:15PM
Epigenetic Transgenerational Inheritance
Room: Grand Ballroom A

Speaker 2 of 6
Emma Whitelaw, Queensland Institute of Medical Research, Australia
Transgenerational Epigenetic Inheritance

Wednesday, March 30 | 5:00PM - 7:15PM
Epigenetic Transgenerational Inheritance
Room: Grand Ballroom A

Speaker 3 of 6
Michael K. Skinner, Washington State University, USA
Epigenetic Transgenerational Inheritance Following Exposure to Endocrine Disruptors

Wednesday, March 30 | 5:00PM - 7:15PM
Epigenetic Transgenerational Inheritance
Room: Grand Ballroom A

Speaker 4 of 6
Douglas Ruden, Wayne State University, USA
Transgenerational Epigenetic Inheritance in Drosophila

Wednesday, March 30 | 5:00PM - 7:15PM
Epigenetic Transgenerational Inheritance
Room: Grand Ballroom A

Speaker 5 of 6
Yoav Soen, Weizmann Institute of Science, Israel
Short Talk: Heritable Epigenesis is beyond the Developmental Program

Wednesday, March 30 | 5:00PM - 7:15PM
Epigenetic Transgenerational Inheritance
Room: Grand Ballroom A

Speaker 6 of 6
Jennifer T. Wolstenholme, University of Virginia, USA
Short Talk: Bisphenol A Alters the Epigenome and Social Behavior over Multiple Generations

Wednesday, March 30 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Grand Ballroom B-C


Wednesday, March 30 | 7:30PM - 10:00PM
Poster Session 3
Room: Grand Ballroom B-C


Thursday, March 31 | 7:30AM - 8:30AM
Breakfast
Room: Grand Ballroom B-C


Thursday, March 31 | 8:30AM - 11:30AM
Epigenetics and Neurological Disorders
Room: Grand Ballroom A

Speaker 1 of 7
* Simon G. Gregory, Duke University, USA

Thursday, March 31 | 8:30AM - 11:30AM
Epigenetics and Neurological Disorders
Room: Grand Ballroom A

Speaker 2 of 7
Art Petronis, University of Toronto, Canada
Epigenomics and Complex Psychiatric Disease

Thursday, March 31 | 8:30AM - 11:30AM
Epigenetics and Neurological Disorders
Room: Grand Ballroom A

Speaker 3 of 7
Janine M. LaSalle, University of California, Davis, USA
Epigenetics at the Interface of Genetic and Environmental Risk Factors for Autism Spectrum Disorders

Thursday, March 31 | 8:30AM - 11:30AM
Epigenetics and Neurological Disorders
Room: Grand Ballroom A

Speaker 4 of 7
Farah D. Lubin, University of Alabama at Birmingham, USA
Histone Methylation in Memory Formation and Aging

Thursday, March 31 | 8:30AM - 11:30AM
Epigenetics and Neurological Disorders
Room: Grand Ballroom A

Speaker 5 of 7
Lorraine Young, University of Nottingham, UK
Modelling Nutritional Programming of the Human Preimplantation Embryo using Embryonic Stem Cells

Thursday, March 31 | 8:30AM - 11:30AM
Epigenetics and Neurological Disorders
Room: Grand Ballroom A

Speaker 6 of 7
Fatemeh G. Haghighi, Columbia University, USA
Short Talk: Role of DNA Methylation in Brain Aging and Depression

Thursday, March 31 | 8:30AM - 11:30AM
Epigenetics and Neurological Disorders
Room: Grand Ballroom A

Speaker 7 of 7
Nagamohan Kommu, BITS Pilani Hyderabad Campus, India
Short Talk: Identification of Candidate Epimutations in One Autism and One Schizophrenia Brain Sample

Thursday, March 31 | 9:50AM - 10:10AM
Coffee Break
Room: Grand Ballroom B-C


Thursday, March 31 | 11:30AM - 11:30AM
On Own for Lunch and Recreation


Thursday, March 31 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Ballroom Foyer


Thursday, March 31 | 5:00PM - 7:00PM
Mammalian Evolution and Disease Susceptibility
Room: Grand Ballroom A

Speaker 1 of 5
* Catherine (Kay) M. Nolan, University College Dublin, Ireland

Thursday, March 31 | 5:00PM - 7:00PM
Mammalian Evolution and Disease Susceptibility
Room: Grand Ballroom A

Speaker 2 of 5
David Haig, Harvard University, USA
Transfers and Transitions: The Evolution of Human Life History

Thursday, March 31 | 5:00PM - 7:00PM
Mammalian Evolution and Disease Susceptibility
Room: Grand Ballroom A

Speaker 3 of 5
Christopher Badcock, London School of Economics and Political Science, UK
The Imprinted Brain Theory: How Genes Set the Balance between Autism and Psychosis

Thursday, March 31 | 5:00PM - 7:00PM
Mammalian Evolution and Disease Susceptibility
Room: Grand Ballroom A

Speaker 4 of 5
Randy L. Jirtle, University of Wisconsin-Madison, USA
Biological Consequences of the Divergent Evolution of IGF2R Imprinting

Thursday, March 31 | 5:00PM - 7:00PM
Mammalian Evolution and Disease Susceptibility
Room: Grand Ballroom A

Speaker 5 of 5
Jan Engelhardt, University of Leipzig, Germany
Short Talk: Evolution of the HOTAIR ncRNA in Vertebrates: Structural and Functional Flexibility of a Scaffold

Thursday, March 31 | 7:00PM - 7:55PM
Closing Remarks
Room: Grand Ballroom A

Speaker 1 of 1
Mark Rothstein, University of Louisville School of Medicine, USA
Legal and Ethical Implications of Epigenetics

Thursday, March 31 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Grand Ballroom B-C


Thursday, March 31 | 8:30PM - 11:30PM
Entertainment
Room: Grand Ballroom B-C


Thursday, March 31 | 8:30PM - 11:30PM
Cash Bar
Room: Grand Ballroom B-C


Friday, April 01 | 10:25AM - 10:25AM
Departure


*Session Chair.