Web Desc
Metabolic Responses to Extreme Conditions
Organizer(s): John R. Speakman, Jan Nedergaard and Sandra L. Martin
Date: April 01 - 05, 2011
Location: Big Sky Resort, Big Sky, MT, USA
Supported by the Directors' Fund
Summary of Meeting:
Animals face a number of extreme stressors to which they must respond. Generally researchers have focused on responses to particular stressful situations, and hence research communities have grown up around these specialized areas. The aim of this meeting is to draw together several of these research communities in a unique interdisciplinary meeting. The aim of bringing such communities together is to allow researchers to explore parallel responses of animals to rather different ‘extremes’. We anticipate this will allow the emergence of common themes and provide an opportunity for researchers to interact with others outside their main areas of interest.
Scholarship Deadline: December 1 2010
Discounted Abstract Deadline: December 1 2010
Abstract Deadline: January 31 2011
Discounted Registration Deadline: February 18 2011
We gratefully acknowledge additional support for this conference from:
Seahorse Bioscience, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK084688-02
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, April 01 | 3:00PM - 7:30PM
Registration
Room: Lower Atrium


Friday, April 01 | 6:15PM - 7:15PM
Refreshments
Room: Lower Atrium


Friday, April 01 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Jefferson

Speaker 1 of 1
Yvon Le Maho, Université de Strasbourg and Centre National de la Recherche Scientifique, France
How Antarctic Penguins Cope with Extreme Conditions and How They May Fail Due to Climate Change

Saturday, April 02 | 7:00AM - 8:00AM
Breakfast
Room: Madison


Saturday, April 02 | 8:00AM - 11:15AM
Caloric Restriction and Starvation
Room: Jefferson
Responses of animals and humans to profound restriction over chronic time scales.
Speaker 7 of 7
Jennifer H. Stern, University of Arizona Cancer Center, USA
Short Talk: The Impact of Calorie Restriction on Whole Body Energy Metabolism in p66Shc(-/-) Mice

Saturday, April 02 | 8:00AM - 11:15AM
Caloric Restriction and Starvation
Room: Jefferson
Responses of animals and humans to profound restriction over chronic time scales.
Speaker 6 of 7
Kevork Hagopian, University of California, Davis, USA
Short Talk: The Influence of Calorie Restriction on H2O2 Production in Mitochondrial Subpopulations from Mouse Liver

Saturday, April 02 | 8:00AM - 11:15AM
Caloric Restriction and Starvation
Room: Jefferson
Responses of animals and humans to profound restriction over chronic time scales.
Speaker 5 of 7
Deborah M. Kristan, California State University San Marcos, USA
Calorie Restriction Produces a Strong Immune Response but does not Protect against Parasite Infection

Saturday, April 02 | 8:00AM - 11:15AM
Caloric Restriction and Starvation
Room: Jefferson
Responses of animals and humans to profound restriction over chronic time scales.
Speaker 4 of 7
John Speakman, Institute of Genetics and Developmental Biology, CAS, China
The Effects of Graded Caloric Restriction on Metabolomic Profiles in Mice

Saturday, April 02 | 8:00AM - 11:15AM
Caloric Restriction and Starvation
Room: Jefferson
Responses of animals and humans to profound restriction over chronic time scales.
Speaker 3 of 7
Carlos M. Isales, Georgia Regents University, USA
Bone Turnover Under Conditions of Caloric Restriction or Selective Nutrient Deprivation

Saturday, April 02 | 8:00AM - 11:15AM
Caloric Restriction and Starvation
Room: Jefferson
Responses of animals and humans to profound restriction over chronic time scales.
Speaker 2 of 7
Susan B. Racette, Washington University School of Medicine, USA
Human Responses to CR: The 'CALERIE' Project

Saturday, April 02 | 8:00AM - 11:15AM
Caloric Restriction and Starvation
Room: Jefferson
Responses of animals and humans to profound restriction over chronic time scales.
Speaker 1 of 7
* Sandra L. Martin, University of Colorado Denver, Anschutz Medical Campus, USA

Saturday, April 02 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Saturday, April 02 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Saturday, April 02 | 11:15AM - 1:00PM
Poster Setup
Room: Madison


Saturday, April 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Madison


Saturday, April 02 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Saturday, April 02 | 5:00PM - 7:00PM
Over-Nutrition
Room: Jefferson
Responses of animals and humans to prolonged excess calorie intake.
Speaker 5 of 5
Banumathi K. Cole, Eastern Virginia Medical School, USA
Short Talk: Nutritional Status Regulates Expression of the Pro-Inflammatory 12/15-Lipoxygenase in Mouse Adipose Tissue

Saturday, April 02 | 5:00PM - 7:00PM
Over-Nutrition
Room: Jefferson
Responses of animals and humans to prolonged excess calorie intake.
Speaker 4 of 5
Donald A. McClain, University of Utah School of Medicine, USA
Short Talk: Metabolic Consequences of Genetic Adaptation to High Altitude in Tibetans

Saturday, April 02 | 5:00PM - 7:00PM
Over-Nutrition
Room: Jefferson
Responses of animals and humans to prolonged excess calorie intake.
Speaker 3 of 5
Hongwei Gao, Brigham and Women's Hospital and Harvard Medical School, USA
Obesity, Bone Metabolism and Inflammation

Saturday, April 02 | 5:00PM - 7:00PM
Over-Nutrition
Room: Jefferson
Responses of animals and humans to prolonged excess calorie intake.
Speaker 2 of 5
Jan Nedergaard, Stockholm University, Sweden
Are we Protected Against Overnutrition?


Saturday, April 02 | 5:00PM - 7:00PM
Over-Nutrition
Room: Jefferson
Responses of animals and humans to prolonged excess calorie intake.
Speaker 1 of 5
* Susan B. Racette, Washington University School of Medicine, USA

Saturday, April 02 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Madison


Saturday, April 02 | 7:30PM - 10:00PM
Poster Session 1
Room: Madison


Sunday, April 03 | 7:00AM - 8:00AM
Breakfast
Room: Madison


Sunday, April 03 | 8:00AM - 11:15AM
Hibernation
Room: Jefferson
Responses of animals to winter that include prolonged torpor and/or body freezing.
Speaker 2 of 7
Sandra L. Martin, University of Colorado Denver, Anschutz Medical Campus, USA
Poly-Omics of Mammalian Hibernation

Sunday, April 03 | 8:00AM - 11:15AM
Hibernation
Room: Jefferson
Responses of animals to winter that include prolonged torpor and/or body freezing.
Speaker 1 of 7
* John Speakman, Institute of Genetics and Developmental Biology, CAS, China

Sunday, April 03 | 8:00AM - 11:15AM
Hibernation
Room: Jefferson
Responses of animals to winter that include prolonged torpor and/or body freezing.
Speaker 3 of 7
Seth W. Donahue, Michigan Technological University, USA
Effects of Hibernation on Bone

Sunday, April 03 | 8:00AM - 11:15AM
Hibernation
Room: Jefferson
Responses of animals to winter that include prolonged torpor and/or body freezing.
Speaker 4 of 7
Kelly L. Drew, University of Alaska, Fairbanks, USA
Seasonal Sensitization in Purinergic Signaling Permits Adenosine A1 Receptor Activation to Induce Torpor in Hibernating Arctic Ground Squirrels

Sunday, April 03 | 8:00AM - 11:15AM
Hibernation
Room: Jefferson
Responses of animals to winter that include prolonged torpor and/or body freezing.
Speaker 5 of 7
Matthew T. Andrews, University of Minnesota, USA
Molecules Regulating Hibernation in Mammals

Sunday, April 03 | 8:00AM - 11:15AM
Hibernation
Room: Jefferson
Responses of animals to winter that include prolonged torpor and/or body freezing.
Speaker 6 of 7
Hannah V. Carey, University of Wisconsin-Madison, USA
Short Talk: Immune Function in Mammalian Hibernation

Sunday, April 03 | 8:00AM - 11:15AM
Hibernation
Room: Jefferson
Responses of animals to winter that include prolonged torpor and/or body freezing.
Speaker 7 of 7
Marshall Hampton, University of Minnesota, Duluth, USA
Short Talk: Deep Sequencing the Transcriptome of the 13-Lined Ground Squirrel: An Emerging Model Organism for Mammalian Hibernation

Sunday, April 03 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Sunday, April 03 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Sunday, April 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Madison


Sunday, April 03 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Sunday, April 03 | 5:00PM - 7:00PM
Molecular Mediators of Extreme Metabolic States
Room: Jefferson

Speaker 1 of 5
* Jan Nedergaard, Stockholm University, Sweden

Sunday, April 03 | 5:00PM - 7:00PM
Molecular Mediators of Extreme Metabolic States
Room: Jefferson

Speaker 2 of 5
Thomas S. Scanlan, Oregon Health & Science University, USA
3-Iodothyronamine: A Novel Bioactive Metabolite of Thyroid Hormone

Sunday, April 03 | 5:00PM - 7:00PM
Molecular Mediators of Extreme Metabolic States
Room: Jefferson

Speaker 3 of 5
Steven J. Swoap, Williams College, USA
AMP vs. Adenosine as a Mediator of Fasting Induced Torpor

Sunday, April 03 | 5:00PM - 7:00PM
Molecular Mediators of Extreme Metabolic States
Room: Jefferson

Speaker 4 of 5
Mark B. Roth, Fred Hutchinson Cancer Research Center, USA
Physiologic Response to Hydrogen Sulfide

Sunday, April 03 | 5:00PM - 7:00PM
Molecular Mediators of Extreme Metabolic States
Room: Jefferson

Speaker 5 of 5
Kevin J. Phillips, Methodist Hospital Research Institute, USA
Short Talk: The Thyroid Hormone Analogue GC-1 Restores Cold Tolerance in Obese (ob/ob) Mice by Rescuing Defects in Adaptive Thermogenesis

Sunday, April 03 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Madison


Sunday, April 03 | 7:30PM - 10:00PM
Poster Session 2
Room: Madison


Monday, April 04 | 7:00AM - 8:00AM
Breakfast
Room: Madison


Monday, April 04 | 8:00AM - 11:15AM
Space
Room: Jefferson
Responses to space flight and microgravity simulation.
Speaker 1 of 7
* Seth W. Donahue, Michigan Technological University, USA

Monday, April 04 | 8:00AM - 11:15AM
Space
Room: Jefferson
Responses to space flight and microgravity simulation.
Speaker 2 of 7
Michael J. Pecaut, Loma Linda University, USA
Impact of the Spaceflight Environment on the Immune System

Monday, April 04 | 8:00AM - 11:15AM
Space
Room: Jefferson
Responses to space flight and microgravity simulation.
Speaker 3 of 7
Maria-Teresa Giardi, National Council of Research-CNR, Italy
Radiation Pressure on D1 Protein Evolution: Space Research and in silico Studies on Chlamydomonas reinhardtii

Monday, April 04 | 8:00AM - 11:15AM
Space
Room: Jefferson
Responses to space flight and microgravity simulation.
Speaker 4 of 7
Adrian LeBlanc, USA
The Effects of Microgravity on Bone

Monday, April 04 | 8:00AM - 11:15AM
Space
Room: Jefferson
Responses to space flight and microgravity simulation.
Speaker 5 of 7
Marco V. Narici, Manchester Metropolitan University, UK
Muscle Loss in Space

Monday, April 04 | 8:00AM - 11:15AM
Space
Room: Jefferson
Responses to space flight and microgravity simulation.
Speaker 6 of 7
Tulasi R. Jinka, University of Alaska Fairbanks, USA
Short Talk: Inhibition of NMDA Type Glutamate Receptors Induces Arousal from Torpor in Hibernating Arctic Ground Squirrels

Monday, April 04 | 8:00AM - 11:15AM
Space
Room: Jefferson
Responses to space flight and microgravity simulation.
Speaker 7 of 7
Scott T. Cooper, University of Wisconsin, La Crosse, USA
Short Talk: Effects of Hibernation on Hemostasis and Fibrinolysis in 13-Lined Ground Squirrels Why Blood Clotting in Hibernators is Cool

Monday, April 04 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Monday, April 04 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, April 04 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Monday, April 04 | 5:00PM - 7:00PM
Hypoxia
Room: Jefferson

Speaker 1 of 5
* Kelly L. Drew, University of Alaska, Fairbanks, USA

Monday, April 04 | 5:00PM - 7:00PM
Hypoxia
Room: Jefferson

Speaker 2 of 5
Vincent Pialoux, Université Claude Bernard Lyon 1, France
Hypoxia and Oxidative Stress in Humans: From Physiology to Pathology

Monday, April 04 | 5:00PM - 7:00PM
Hypoxia
Room: Jefferson

Speaker 3 of 5
Robert S. Mazzeo, University of Colorado, USA
Altitude and Immune Function

Monday, April 04 | 5:00PM - 7:00PM
Hypoxia
Room: Jefferson

Speaker 4 of 5
Zachary A. Cheviron, University of Nebraska, USA
Ecological Genomics of High-Altitude Adaptation

Monday, April 04 | 5:00PM - 7:00PM
Hypoxia
Room: Jefferson

Speaker 5 of 5
Dana L. Miller, University of Washington, USA
Short Talk: Hydrogen Sulfide Protects Against Hypoxia in C. elegans

Monday, April 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Madison


Monday, April 04 | 8:00PM - 11:00PM
Entertainment
Room: Madison


Monday, April 04 | 8:00PM - 11:00PM
Cash Bar
Room: Madison


Tuesday, April 05 | 10:25AM - 10:25AM
Departure


*Session Chair.