Web Desc
B Cells: New Insights into Normal versus Dysregulated Function
Organizer(s): David J. Rawlings, Frances E. Lund, Stuart G. Tangye and John G. Monroe
Date: April 12 - 17, 2011
Location: Fairmont Chateau Whistler, Whistler, BC, Canada
Sponsored by Amgen Inc.
Summary of Meeting:
B lymphocytes play crucial roles in host defense against infection via a series of highly coordinated processes that include cell homing, antigen recognition, antibody secretion, antigen presentation, and/or cytokine release. To accomplish these myriad functions, B cells must maneuver through a complex series of primary and secondary developmental, homoeostatic, and activation-triggered checkpoints. These checkpoints dictate stochastic and molecularly directed events dependent upon local micro-environments, cell-cell interactions, and interactions with pathogenic or non-pathogenic organisms. Early events in this developmental cascade promote the generation of a diverse B cell antigen receptor repertoire that is essential for both survival and entry into downstream effector populations. In parallel, this repertoire is tested for self-reactivity at multiple steps leading to either loss or expansion of specific clones. Dysregulation of these complex processes can lead, alternatively, to immunodeficiency, autoimmune, or malignant disease. The overall goal of this meeting is to highlight recent studies of normal versus abnormal B cell development and function with an emphasis whenever possible on data using human models.
Scholarship Deadline: December 13 2010
Discounted Abstract Deadline: December 13 2010
Abstract Deadline: January 18 2011
Discounted Registration Deadline: February 11 2011
We gratefully acknowledge additional support for this conference from:
Educational donation provided by Amgen
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI094881-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, April 12 | 3:00PM - 7:30PM
Registration
Room: Macdonald Foyer


Tuesday, April 12 | 6:15PM - 7:15PM
Refreshments
Room: Macdonald Foyer


Tuesday, April 12 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Macdonald D E F

Speaker 1 of 2
* David J. Rawlings, University of Washington, Seattle Children's Hospital Research Institute, USA
Introduction

Tuesday, April 12 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Macdonald D E F

Speaker 2 of 2
Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Mechanism of Actively Acquired Tolerance or Immunity: Progress and Problems 50 Years After the Burnet-Medawar Nobel Prize

Wednesday, April 13 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac A B C


Wednesday, April 13 | 8:00AM - 11:15AM
Conventional (or Adaptive) B Cell Development
Room: Macdonald D E F

Speaker 1 of 7
* John G. Monroe, Genentech, Inc., USA

Wednesday, April 13 | 8:00AM - 11:15AM
Conventional (or Adaptive) B Cell Development
Room: Macdonald D E F

Speaker 2 of 7
Barbara Lynne Kee, University of Chicago, USA
E Protein Transcription Factors and Lymphoid Specification

Wednesday, April 13 | 8:00AM - 11:15AM
Conventional (or Adaptive) B Cell Development
Room: Macdonald D E F

Speaker 3 of 7
Malay Mandal, University of Chicago, USA
Short Talk: Genetic and Epigenetic Repression of the Igkappa Intronic Enhancer by STAT5

Wednesday, April 13 | 8:00AM - 11:15AM
Conventional (or Adaptive) B Cell Development
Room: Macdonald D E F

Speaker 4 of 7
Brian M. Iritani, University of Washington, USA
Short Talk: Identification of a Novel Metabolic Regulator Controlling B Lymphocyte Development

Wednesday, April 13 | 8:00AM - 11:15AM
Conventional (or Adaptive) B Cell Development
Room: Macdonald D E F

Speaker 5 of 7
Harinder Singh, Cincinnati Children's Hospital Medical Center, USA
The Regulatory and Molecular Logic of IL-7R and pre-BCR Signaling in B Cell Development

Wednesday, April 13 | 8:00AM - 11:15AM
Conventional (or Adaptive) B Cell Development
Room: Macdonald D E F

Speaker 6 of 7
Ann J. Feeney, The Scripps Research Institute, USA
Epigenetic and 3-Dimensional Regulation of Antibody Repertoire Formation

Wednesday, April 13 | 8:00AM - 11:15AM
Conventional (or Adaptive) B Cell Development
Room: Macdonald D E F

Speaker 7 of 7
Robert C. Rickert, Pfizer Inc., USA
Elimination of Self-Reactive B Cells by Follicular Dendritic Cell-Bound Antigen

Wednesday, April 13 | 9:20AM - 9:40AM
Coffee Break
Room: Macdonald Foyer


Wednesday, April 13 | 11:15AM - 1:00PM
Poster Setup
Room: Macdonald A B C


Wednesday, April 13 | 11:15AM - 11:15AM
On Own for Lunch


Wednesday, April 13 | 12:30PM - 2:30PM
Workshop 1A: Tonic and Naive B Cell Signaling
Room: MacDonald D

Speaker 1 of 7
Anselm Enders, John Curtin School of Medical Research, Australia
ATP11c is Critical for Phosphatidylserine Internalization and B Lymphocyte Differentiation

Wednesday, April 13 | 12:30PM - 2:30PM
Workshop 1A: Tonic and Naive B Cell Signaling
Room: MacDonald D

Speaker 2 of 7
Julie Zikherman, University of California, San Francisco, USA
Titration of CD45 Expression Regulates Sequential Tolerance Checkpoints during B Cell Development

Wednesday, April 13 | 12:30PM - 2:30PM
Workshop 1A: Tonic and Naive B Cell Signaling
Room: MacDonald D

Speaker 3 of 7
* Randall S. Davis, University of Alabama, Birmingham, USA
FCRL5 has Dual Modulatory and Compartment-Specific Influence on Innate-Like B Cell Receptor Signaling

Wednesday, April 13 | 12:30PM - 2:30PM
Workshop 1A: Tonic and Naive B Cell Signaling
Room: MacDonald D

Speaker 4 of 7
Haewon Sohn, NIAID, National Institutes of Health, USA
The Potential of FcRL4 to Function as an Adaptive to Innate Molecular Switch in Exhausted Memory B Cells

Wednesday, April 13 | 12:30PM - 2:30PM
Workshop 1A: Tonic and Naive B Cell Signaling
Room: MacDonald D

Speaker 5 of 7
Mary Kaileh, NIH/NIA, USA
PI3K-Dependent Production of NF-kappaB2 Protein by Tonic B Cell Receptor Signaling Mediates Effective Responsiveness to BAFF

Wednesday, April 13 | 12:30PM - 2:30PM
Workshop 1A: Tonic and Naive B Cell Signaling
Room: MacDonald D

Speaker 6 of 7
Edina Andrea Schweighoffer, Francis Crick Institute - Mill Hill Laboratory, UK
BCR Tonic Signalling and B Cell Survival

Wednesday, April 13 | 12:30PM - 2:30PM
Workshop 1A: Tonic and Naive B Cell Signaling
Room: MacDonald D

Speaker 7 of 7
Emilie Jacque, National Institute for Medical Research, UK
IKK-Induced NF-kappaB1 p105 Proteolysis is Essential for Mature B Cell Function in T-Dependent and T-Independent Immune Responses

Wednesday, April 13 | 12:30PM - 2:30PM
Workshop 1B: Germinal Cell Biology
Room: MacDonald EF

Speaker 1 of 9
* Ann M. Haberman, Yale University School of Medicine, USA

Wednesday, April 13 | 12:30PM - 2:30PM
Workshop 1B: Germinal Cell Biology
Room: MacDonald EF

Speaker 2 of 9
Darran G. Cronshaw, Feinstein Institute for Medical Research, USA
Grb2 Signaling in B Cells Controls Lymphoid Follicle Organization and Germinal Center Reaction

Wednesday, April 13 | 12:30PM - 2:30PM
Workshop 1B: Germinal Cell Biology
Room: MacDonald EF

Speaker 3 of 9
* Troy D. Randall, University of Alabama at Birmingham, USA
IL-17 Controls Ectopic Lymphoid Tissue Development

Wednesday, April 13 | 12:30PM - 2:30PM
Workshop 1B: Germinal Cell Biology
Room: MacDonald EF

Speaker 4 of 9
Neda Nikbakht, Thomas Jefferson University, USA
Cell-Cell Interactions Associated with the Intrafollicular B Cell Migratory Program Required for Initiation of Germinal Centers

Wednesday, April 13 | 12:30PM - 2:30PM
Workshop 1B: Germinal Cell Biology
Room: MacDonald EF

Speaker 5 of 9
Saya Moriyama, RIKEN, Research Center for Allergy and Immunology, Japan
BCL6 Protein Expression Shapes Pre-Germinal Center B Cell Dynamics and Follicular Helper T Cell Heterogeneity

Wednesday, April 13 | 12:30PM - 2:30PM
Workshop 1B: Germinal Cell Biology
Room: MacDonald EF

Speaker 6 of 9
Natalia Sol Chaimowitz, Virginia Commonwealth University, USA
ADAM10 is Critical for Germinal Center Formation and Antibody Responses

Wednesday, April 13 | 12:30PM - 2:30PM
Workshop 1B: Germinal Cell Biology
Room: MacDonald EF

Speaker 7 of 9
Elissa K. Deenick, Garvan Institute of Medical Research, Australia
Follicular Helper T Cell Differentiation Requires Continuous Antigen Presentation but not a Unique B Cell Signal

Wednesday, April 13 | 12:30PM - 2:30PM
Workshop 1B: Germinal Cell Biology
Room: MacDonald EF

Speaker 8 of 9
Uttiya Basu, USA
Regulation of Activation Induced Deaminase DNA Deamination Activity by Non-Coding RNA Surveillance Pathway

Wednesday, April 13 | 12:30PM - 2:30PM
Workshop 1B: Germinal Cell Biology
Room: MacDonald EF

Speaker 9 of 9
Shengli Xu, Bioprocessing Technology Institute, Singapore
The RNase III Enzyme Dicer is Essential for Germinal Center B Cell Formation during T Cell-Dependent Immune Response

Wednesday, April 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Macdonald A B C


Wednesday, April 13 | 2:30PM - 4:30PM
Workshop 1C: Autoimmunity and Immunodeficiency I (Mechanisms
of Autoimmunity and Human Disease)
Room: MacDonald EF

Speaker 1 of 10
* Anne B. Satterthwaite, University of Texas Southwestern Medical Center, USA

Wednesday, April 13 | 2:30PM - 4:30PM
Workshop 1C: Autoimmunity and Immunodeficiency I (Mechanisms
of Autoimmunity and Human Disease)
Room: MacDonald EF

Speaker 2 of 10
* Shiv Pillai, Massachusetts General Hospital, USA

Wednesday, April 13 | 2:30PM - 4:30PM
Workshop 1C: Autoimmunity and Immunodeficiency I (Mechanisms
of Autoimmunity and Human Disease)
Room: MacDonald EF

Speaker 3 of 10
Anatoly V. Rubtsov, University of Colorado Health Sciences Center, USA
TLR7 Signaling Drives the Accumulation of a Novel CD11c+ B Cell Population that is Critical for the Development of Autoimmunity

Wednesday, April 13 | 2:30PM - 4:30PM
Workshop 1C: Autoimmunity and Immunodeficiency I (Mechanisms
of Autoimmunity and Human Disease)
Room: MacDonald EF

Speaker 4 of 10
Maria A. Gutierrez, University of Texas Southwestern Medical Center, USA
Role of Bruton’s Tyrosine Kinase (Btk) and IL-6 in Regulating Plasma Cell Accumulation and IgG Autoantibody Production in lyn-/- Mice

Wednesday, April 13 | 2:30PM - 4:30PM
Workshop 1C: Autoimmunity and Immunodeficiency I (Mechanisms
of Autoimmunity and Human Disease)
Room: MacDonald EF

Speaker 5 of 10
Isis Ludwig-Portugall, Institute of Experimental Immunology, Germany
Autoantibody Production, Expansion and Survival of Autoreactive B Cells against Non Lymphoid Tissue Ag is Controlled by Ag Specific Treg

Wednesday, April 13 | 2:30PM - 4:30PM
Workshop 1C: Autoimmunity and Immunodeficiency I (Mechanisms
of Autoimmunity and Human Disease)
Room: MacDonald EF

Speaker 6 of 10
Allison L. Sang, Morphic Therapeutic, USA
Antigen Specific and Non-Specific Activation of Rheumatoid Factor B-Cells in the Triple Congenic Mouse Model of Lupus

Wednesday, April 13 | 2:30PM - 4:30PM
Workshop 1C: Autoimmunity and Immunodeficiency I (Mechanisms
of Autoimmunity and Human Disease)
Room: MacDonald EF

Speaker 7 of 10
Edgar D. Charles, Rockefeller University, USA
Somatic Hypermutations Confer Rheumatoid Factor Activity in Hepatitis C Virus-Associated Mixed Cryoglobulinemia

Wednesday, April 13 | 2:30PM - 4:30PM
Workshop 1C: Autoimmunity and Immunodeficiency I (Mechanisms
of Autoimmunity and Human Disease)
Room: MacDonald EF

Speaker 8 of 10
Nathalie Bonnefoy-Berard, INSERM U851, France
Role of IL-17 and BAFF in B Cell Biology and Systemic Lupus Erythematosus (SLE) Pathophysiology

Wednesday, April 13 | 2:30PM - 4:30PM
Workshop 1C: Autoimmunity and Immunodeficiency I (Mechanisms
of Autoimmunity and Human Disease)
Room: MacDonald EF

Speaker 9 of 10
Yuri Fedoriw, University of North Carolina, USA
Decreased TdT+ Bone Marrow B Cell Precursors after Allogeneic Stem Cell Transplantation is Associated with Development of Human Chronic Graft versus Host Disease (cGVHD)

Wednesday, April 13 | 2:30PM - 4:30PM
Workshop 1C: Autoimmunity and Immunodeficiency I (Mechanisms
of Autoimmunity and Human Disease)
Room: MacDonald EF

Speaker 10 of 10
Kendra N. Taylor, Massachusetts General Hospital, USA
Utilizing the Surface 9-O-Acetylation State of B-Cells to Classify SLE Patients

Wednesday, April 13 | 4:30PM - 5:00PM
Coffee Available
Room: Macdonald Foyer


Wednesday, April 13 | 5:00PM - 7:00PM
B Cell Activation and Co-Receptor Signaling
Room: Macdonald D E F

Speaker 1 of 5
* David J. Rawlings, University of Washington, Seattle Children's Hospital Research Institute, USA

Wednesday, April 13 | 5:00PM - 7:00PM
B Cell Activation and Co-Receptor Signaling
Room: Macdonald D E F

Speaker 2 of 5
Tomohiro Kurosaki, Osaka University, Japan
Function of Store-Operated Calcium Entry in B Lymphocytes

Wednesday, April 13 | 5:00PM - 7:00PM
B Cell Activation and Co-Receptor Signaling
Room: Macdonald D E F

Speaker 3 of 5
Facundo D. Batista, Massachusetts Institute of Technology and Harvard University, USA
Early Events in B Cell Activation: From Single Molecules to Living Tissue

Wednesday, April 13 | 5:00PM - 7:00PM
B Cell Activation and Co-Receptor Signaling
Room: Macdonald D E F

Speaker 4 of 5
Jürgen Wienands, Georg August University of Goettingen, Germany
Activation Signals for Naïve and Class-switched Memory B Cells

Wednesday, April 13 | 5:00PM - 7:00PM
B Cell Activation and Co-Receptor Signaling
Room: Macdonald D E F

Speaker 5 of 5
Wanli Liu, Tsinghua University, China
Short Talk: The Tale of a Tail: The Role of Disk Large Homolog 1 (Dlg1) in Isotype-Switched IgG-BCR Signaling

Wednesday, April 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Macdonald A B C


Wednesday, April 13 | 7:30PM - 10:00PM
Poster Session 1
Room: Macdonald A B C


Thursday, April 14 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac A B C


Thursday, April 14 | 8:00AM - 11:15AM
Innate B Cells
Room: Macdonald D E F

Speaker 1 of 7
* John F. Kearney, University of Alabama, Birmingham, USA

Thursday, April 14 | 8:00AM - 11:15AM
Innate B Cells
Room: Macdonald D E F

Speaker 2 of 7
Kenneth A. Dorshkind, University of California, Los Angeles, USA
B Cell Developmental Programs from Embryogenesis through Senescence

Thursday, April 14 | 8:00AM - 11:15AM
Innate B Cells
Room: Macdonald D E F

Speaker 3 of 7
Nicole Baumgarth, University of California, Davis, USA
Innate Regulation of B-1 Cell Responses to Influenza Infection

Thursday, April 14 | 8:00AM - 11:15AM
Innate B Cells
Room: Macdonald D E F

Speaker 4 of 7
Thomas L. Rothstein, Western Michigan University, USA
Short Talk: Human B1 Cells Express the Novel Phenotype: CD20+CD27+CD43+CD70-

Thursday, April 14 | 8:00AM - 11:15AM
Innate B Cells
Room: Macdonald D E F

Speaker 5 of 7
Andrea Cerutti, Mount Sinai School of Medicine, USA
Innate Signaling Networks in Memory B Cell Responses

Thursday, April 14 | 8:00AM - 11:15AM
Innate B Cells
Room: Macdonald D E F

Speaker 6 of 7
Ralf Küppers, University of Duisburg-Essen, Medical School, Germany
Human B Cell Subsets and the Cellular Origin of Chronic Lymphocytic Leukemia

Thursday, April 14 | 8:00AM - 11:15AM
Innate B Cells
Room: Macdonald D E F

Speaker 7 of 7
Yi Hao, Huazhong University of Science & Technology, China
Short Talk: An Innate-Like B Cell Subset Expands with Age

Thursday, April 14 | 9:20AM - 9:40AM
Coffee Break
Room: Macdonald Foyer


Thursday, April 14 | 11:15AM - 1:00PM
Poster Setup
Room: Macdonald A B C


Thursday, April 14 | 11:15AM - 11:15AM
On Own for Lunch


Thursday, April 14 | 12:30PM - 2:30PM
Workshop 2A: Autoimmunity and Immunodeficiency II (Tolerance
Checkpoints and Novel Therapies)
Room: Macdonald EF

Speaker 1 of 9
* Nina Luning Prak, University of Pennsylvania, USA

Thursday, April 14 | 12:30PM - 2:30PM
Workshop 2A: Autoimmunity and Immunodeficiency II (Tolerance
Checkpoints and Novel Therapies)
Room: Macdonald EF

Speaker 2 of 9
Wenzhao Meng, University of Pennsylvania, USA
VH Gene Selection at the Pro-B to Pre-B Cell Transition in C57BL6/J Mice

Thursday, April 14 | 12:30PM - 2:30PM
Workshop 2A: Autoimmunity and Immunodeficiency II (Tolerance
Checkpoints and Novel Therapies)
Room: Macdonald EF

Speaker 3 of 9
Sarah F. Andrews, National Institutes of Health, USA
B Cell Receptor Light Chain Specificity Strongly Influences Mechanisms of B Cell Tolerance

Thursday, April 14 | 12:30PM - 2:30PM
Workshop 2A: Autoimmunity and Immunodeficiency II (Tolerance
Checkpoints and Novel Therapies)
Room: Macdonald EF

Speaker 4 of 9
Lisa M. Russell, NIA, National Institutes of Health, USA
The Transcription Factor Ets-1 is Required for Peripheral B Cell Tolerance to Self-Antigens

Thursday, April 14 | 12:30PM - 2:30PM
Workshop 2A: Autoimmunity and Immunodeficiency II (Tolerance
Checkpoints and Novel Therapies)
Room: Macdonald EF

Speaker 5 of 9
Xuezhi Dai, Seattle Childrens' Research Institute, USA
Developmentally Regulated Control of MEF2C Limits Early Transitional B Cell Response to BCR Crosslinking

Thursday, April 14 | 12:30PM - 2:30PM
Workshop 2A: Autoimmunity and Immunodeficiency II (Tolerance
Checkpoints and Novel Therapies)
Room: Macdonald EF

Speaker 6 of 9
* Roberta Pelanda, University of Colorado Denver, USA
Human B Cell Development and Selection in Hematopoietic Humanized Mice

Thursday, April 14 | 12:30PM - 2:30PM
Workshop 2A: Autoimmunity and Immunodeficiency II (Tolerance
Checkpoints and Novel Therapies)
Room: Macdonald EF

Speaker 7 of 9
Ian R. Hardy, TCR2 Therapeutics, USA
Therapeutic Benefit of anti-CD79b Antibodies

Thursday, April 14 | 12:30PM - 2:30PM
Workshop 2A: Autoimmunity and Immunodeficiency II (Tolerance
Checkpoints and Novel Therapies)
Room: Macdonald EF

Speaker 8 of 9
Charlotte M. Starke, University Erlangen-Nuremberg, Germany
Autoreactive Short- and Long-Lived Plasma Cells within Nephritic Kidneys of Lupus Mice are Susceptible to Bortezomib

Thursday, April 14 | 12:30PM - 2:30PM
Workshop 2A: Autoimmunity and Immunodeficiency II (Tolerance
Checkpoints and Novel Therapies)
Room: Macdonald EF

Speaker 9 of 9
Rachel H. Bonami, Vanderbilt University, USA
Autoantigen-Targeted Therapy Removes Anti-Insulin B Lymphocytes that Escape Immune Tolerance Checkpoints in Type 1 Diabetes-Prone NOD Mice

Thursday, April 14 | 12:30PM - 2:30PM
Workshop 2B: Regulatory and Innate B Cells
Room: MacDonald D

Speaker 1 of 9
* Thomas L. Rothstein, Western Michigan University, USA

Thursday, April 14 | 12:30PM - 2:30PM
Workshop 2B: Regulatory and Innate B Cells
Room: MacDonald D

Speaker 2 of 9
* Elizabeth A. Leadbetter, University of Texas Long School of Medicine, USA
IL-21-Producing iNKT Cells Direct a Novel B Cell Response to a Cognate Lipid Antigen

Thursday, April 14 | 12:30PM - 2:30PM
Workshop 2B: Regulatory and Innate B Cells
Room: MacDonald D

Speaker 3 of 9
Sara M. Lind Enoksson, Karolinska Institutet, Sweden
IL-18 Induces Natural Antibody Responses Regulated by NKT Cells

Thursday, April 14 | 12:30PM - 2:30PM
Workshop 2B: Regulatory and Innate B Cells
Room: MacDonald D

Speaker 4 of 9
Jelle de Wit, Sanquin Research, Netherlands
B Cells Phagocytosing Bacteria Solicit Aid for Antibody Production by Induction of IL-21 in a Novel IFN-gamma+/IL-21+ Th1 Subset Suppressing Detrimental IL-4 Expression

Thursday, April 14 | 12:30PM - 2:30PM
Workshop 2B: Regulatory and Innate B Cells
Room: MacDonald D

Speaker 5 of 9
Luciën E.P.M van der Vlugt, Leiden University Medical Center, Netherlands
IL-10 Producing Splenic B Cells are Involved in Schistosome-Induced Protection against Allergic Airway Inflammation

Thursday, April 14 | 12:30PM - 2:30PM
Workshop 2B: Regulatory and Innate B Cells
Room: MacDonald D

Speaker 6 of 9
Sylvie Amu, Trinity College Dublin, Ireland
Helminth-Induced B Effector and B Regulatory Cells have Differential Effects in Experimental Autoimmune Encephalomyelitis

Thursday, April 14 | 12:30PM - 2:30PM
Workshop 2B: Regulatory and Innate B Cells
Room: MacDonald D

Speaker 7 of 9
Marc Seifert, University of Duisburg-Essen, Germany
Molecular Analysis of Human Peripheral Blood CD5+ B Cells: The Existence of CD5+ Post-Germinal Center Memory B Cells

Thursday, April 14 | 12:30PM - 2:30PM
Workshop 2B: Regulatory and Innate B Cells
Room: MacDonald D

Speaker 8 of 9
Eliver Eid Bou Ghosn, Emory University, USA
Distinct Progenitors for B-1 and B-2 Cells are Present in Adult Mouse Spleen

Thursday, April 14 | 12:30PM - 2:30PM
Workshop 2B: Regulatory and Innate B Cells
Room: MacDonald D

Speaker 9 of 9
Daniel O. Griffin, Feinstein Institute, USA
Human B1 Cell Immunoglobulin Specificity: When Less is More

Thursday, April 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Macdonald A B C


Thursday, April 14 | 2:30PM - 4:30PM
Workshop 2C: Plasma Cells and Antibody Response/Repertoire
Room: MacDonald EF

Speaker 1 of 9
* David M. Allman, University of Pennsylvania, USA

Thursday, April 14 | 2:30PM - 4:30PM
Workshop 2C: Plasma Cells and Antibody Response/Repertoire
Room: MacDonald EF

Speaker 2 of 9
* John F. Kearney, University of Alabama, Birmingham, USA
Modulation of Type 1 Diabetes by Anti-N-acetyl-D-glucosamine Antibodies

Thursday, April 14 | 2:30PM - 4:30PM
Workshop 2C: Plasma Cells and Antibody Response/Repertoire
Room: MacDonald EF

Speaker 3 of 9
David R. Fooksman, Albert Einstein College of Medicine, USA
Development and Migration of Pre-Plasma Cells in the Mouse Lymph Node

Thursday, April 14 | 2:30PM - 4:30PM
Workshop 2C: Plasma Cells and Antibody Response/Repertoire
Room: MacDonald EF

Speaker 4 of 9
Bertrand Huard, Centre Medical Universitaire, Switzerland
Myeloid Precursor Cells Promote Plasma-Cell Survival by Constitutively Secreting APRIL in the Bone Marrow

Thursday, April 14 | 2:30PM - 4:30PM
Workshop 2C: Plasma Cells and Antibody Response/Repertoire
Room: MacDonald EF

Speaker 5 of 9
Nicholas A. Barnes, Leeds Institute of Molecular Medicine, UK
BLIMP-1 Represses miR-21 During Plasma Cell Differentiation

Thursday, April 14 | 2:30PM - 4:30PM
Workshop 2C: Plasma Cells and Antibody Response/Repertoire
Room: MacDonald EF

Speaker 6 of 9
Henrik E. Mei, German Rheumatism Research Center, Germany
Chronic Differentiation of Human Mucosal IgA-Secreting Cells during B Cell Depletion Therapy with Rituximab

Thursday, April 14 | 2:30PM - 4:30PM
Workshop 2C: Plasma Cells and Antibody Response/Repertoire
Room: MacDonald EF

Speaker 7 of 9
Huizhong Xiong, Genentech, Inc., USA
High Affinity IgE Antibody Generation Requires an IgG Germinal Center Phase

Thursday, April 14 | 2:30PM - 4:30PM
Workshop 2C: Plasma Cells and Antibody Response/Repertoire
Room: MacDonald EF

Speaker 8 of 9
David M. Allman, University of Pennsylvania, USA
Long-Lived CD19+ Plasma Cells Induced with a T Cell Independent Antigen

Thursday, April 14 | 2:30PM - 4:30PM
Workshop 2C: Plasma Cells and Antibody Response/Repertoire
Room: MacDonald EF

Speaker 9 of 9
Zhiyong Yang, University of California, San Francisco, USA
A Novel Fluorescent Reporter for Tracking IgE+ B Cells in vivo

Thursday, April 14 | 4:30PM - 5:00PM
Coffee Available
Room: Macdonald Foyer


Thursday, April 14 | 5:00PM - 7:00PM
Effector and Regulatory B Cell Function
Room: Macdonald D E F

Speaker 1 of 5
* Anthony L. DeFranco, University of California, San Francisco, USA

Thursday, April 14 | 5:00PM - 7:00PM
Effector and Regulatory B Cell Function
Room: Macdonald D E F

Speaker 2 of 5
Frances E. Lund, University of Alabama at Birmingham, USA
Impairment of Dendritic Cell, CD4 T Cell and CD8 T Cell Mediated Immune Responses following B Cell Depletion

Thursday, April 14 | 5:00PM - 7:00PM
Effector and Regulatory B Cell Function
Room: Macdonald D E F

Speaker 3 of 5
David Gray, University of Edinburgh, UK
Programming and Regulation of T Cells by B Cells

Thursday, April 14 | 5:00PM - 7:00PM
Effector and Regulatory B Cell Function
Room: Macdonald D E F

Speaker 4 of 5
Claudia Mauri, University College London, UK
Regulatory B Cell in Health and Disease

Thursday, April 14 | 5:00PM - 7:00PM
Effector and Regulatory B Cell Function
Room: Macdonald D E F

Speaker 5 of 5
Wei Xu, Roche Innovation Center Zurich, Switzerland
Short Talk: Macrophages Induce Terminal Differentiation of Plasma Cells through CXCL10/IP-10

Thursday, April 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Macdonald A B C


Thursday, April 14 | 7:30PM - 10:00PM
Poster Session 2
Room: Macdonald A B C


Friday, April 15 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac A B C


Friday, April 15 | 8:00AM - 11:15AM
GC Reaction and B Cell Memory
Room: Macdonald D E F

Speaker 1 of 8
* Stuart G. Tangye, Garvan Institute of Medical Research, Australia

Friday, April 15 | 8:00AM - 11:15AM
GC Reaction and B Cell Memory
Room: Macdonald D E F

Speaker 2 of 8
David M. Tarlinton, Monash University, Australia
Memory B Cell and Plasma Cell Differentiation

Friday, April 15 | 8:00AM - 11:15AM
GC Reaction and B Cell Memory
Room: Macdonald D E F

Speaker 3 of 8
Jesse Green, University of California, San Francisco, USA
Short Talk: S1P-Receptor 2 Regulation of Germinal Center B Cell Growth

Friday, April 15 | 8:00AM - 11:15AM
GC Reaction and B Cell Memory
Room: Macdonald D E F

Speaker 4 of 8
Claudia Berek, Deutsches Rheuma Forschungszentrum, Germany
Short Talk: Eosinophils are Required for the Long-Term Survival of Plasma Cells in the Bone Marrow

Friday, April 15 | 8:00AM - 11:15AM
GC Reaction and B Cell Memory
Room: Macdonald D E F

Speaker 5 of 8
Anthony L. DeFranco, University of California, San Francisco, USA
Selective Utilization of TLR/MyD88 Signaling in B Cells for Enhancement of the Anti-Viral Germinal Center Response

Friday, April 15 | 8:00AM - 11:15AM
GC Reaction and B Cell Memory
Room: Macdonald D E F

Speaker 6 of 8
Carola G. Vinuesa, Australian National University, Australia
Tfh Cells and Memory B Cell Selection

Friday, April 15 | 8:00AM - 11:15AM
GC Reaction and B Cell Memory
Room: Macdonald D E F

Speaker 7 of 8
Ann M. Haberman, Yale University School of Medicine, USA
Short Talk: Inter-Follicular Germinal Center B Cell and T Follicular Helper Cell Development Precedes Follicular Tfh Maintenance

Friday, April 15 | 8:00AM - 11:15AM
GC Reaction and B Cell Memory
Room: Macdonald D E F

Speaker 8 of 8
Kathryn A. Pape, University of Minnesota, USA
Short Talk: Different B Cell Populations Mediate Early and Late Memory during an Endogenous Immune Response

Friday, April 15 | 9:20AM - 9:40AM
Coffee Break
Room: Macdonald Foyer


Friday, April 15 | 11:15AM - 1:00PM
Poster Setup
Room: Macdonald A B C


Friday, April 15 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Friday, April 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Macdonald A B C


Friday, April 15 | 4:30PM - 5:00PM
Coffee Available
Room: Macdonald Foyer


Friday, April 15 | 5:00PM - 7:00PM
GC Transcriptional Programs and Alterations in B Lymphoma
Room: Macdonald D E F

Speaker 1 of 5
* Ralf Küppers, University of Duisburg-Essen, Medical School, Germany

Friday, April 15 | 5:00PM - 7:00PM
GC Transcriptional Programs and Alterations in B Lymphoma
Room: Macdonald D E F

Speaker 2 of 5
Ari M. Melnick, Weill Cornell Medical College, USA
Transcriptional Programming in Normal and Malignant Germinal Center B Cells

Friday, April 15 | 5:00PM - 7:00PM
GC Transcriptional Programs and Alterations in B Lymphoma
Room: Macdonald D E F

Speaker 3 of 5
Rafael Casellas, NIAMS-NCI, National Institutes of Health, USA
Seq-ing AID in B Cell Tumor Development

Friday, April 15 | 5:00PM - 7:00PM
GC Transcriptional Programs and Alterations in B Lymphoma
Room: Macdonald D E F

Speaker 4 of 5
Louis M. Staudt, NCI, National Institutes of Health, USA
Converging on the Achilles Heel of Lymphoma through Functional and Structural Genomics

Friday, April 15 | 5:00PM - 7:00PM
GC Transcriptional Programs and Alterations in B Lymphoma
Room: Macdonald D E F

Speaker 5 of 5
Soungchul Cha, MD Anderson Cancer Center, USA
Short Talk: Nonstereotypic Follicular Lymphoma B-Cell Receptors Recognize Vimentin as a Shared Autoantigen

Friday, April 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Macdonald A B C


Friday, April 15 | 7:30PM - 10:00PM
Poster Session 3
Room: Macdonald A B C


Saturday, April 16 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac A B C


Saturday, April 16 | 8:00AM - 11:15AM
B Cell Genetic Alterations Linked to Cell Intrinsic Autoimmu
nity and/or Immunodeficiency

Room: Macdonald D E F

Speaker 1 of 7
* Christopher C. Goodnow, Garvan Institute of Medical Research, Australia

Saturday, April 16 | 8:00AM - 11:15AM
B Cell Genetic Alterations Linked to Cell Intrinsic Autoimmu
nity and/or Immunodeficiency

Room: Macdonald D E F

Speaker 2 of 7
Edward K. Wakeland, University of Texas Southwestern Medical Center, USA
B Cell Function in Murine Models of SLE

Saturday, April 16 | 8:00AM - 11:15AM
B Cell Genetic Alterations Linked to Cell Intrinsic Autoimmu
nity and/or Immunodeficiency

Room: Macdonald D E F

Speaker 3 of 7
Jane H. Buckner, Benaroya Research Institute at Virginia Mason, USA
PTPN22 Modulates B Cell Tolerance in Human Autoimmunity

Saturday, April 16 | 8:00AM - 11:15AM
B Cell Genetic Alterations Linked to Cell Intrinsic Autoimmu
nity and/or Immunodeficiency

Room: Macdonald D E F

Speaker 4 of 7
David J. Rawlings, University of Washington, Seattle Children's Hospital Research Institute, USA
WASp-/- B Cells Promote Humoral Autoimmunity

Saturday, April 16 | 8:00AM - 11:15AM
B Cell Genetic Alterations Linked to Cell Intrinsic Autoimmu
nity and/or Immunodeficiency

Room: Macdonald D E F

Speaker 5 of 7
Kerstin Nündel, University of Massachusetts Medical School, USA
Short Talk: Self-Ligand Dependent Selection of Rheumatoid Factor B Cells into the Marginal Zone Compartment

Saturday, April 16 | 8:00AM - 11:15AM
B Cell Genetic Alterations Linked to Cell Intrinsic Autoimmu
nity and/or Immunodeficiency

Room: Macdonald D E F

Speaker 6 of 7
Tyani D. Chan, Garvan Institute of Medical Research, Australia
Short Talk: Molecular Mimicry and the Production of Autoantibody via the Germinal Centre Reaction

Saturday, April 16 | 8:00AM - 11:15AM
B Cell Genetic Alterations Linked to Cell Intrinsic Autoimmu
nity and/or Immunodeficiency

Room: Macdonald D E F

Speaker 7 of 7
Stuart G. Tangye, Garvan Institute of Medical Research, Australia
Consequences of Loss-of Function Mutations in Primary Immunodeficiencies on Human B Cell Differentiation and Long-Lived Humoral Immunity

Saturday, April 16 | 9:00AM - 9:20AM
Coffee Break
Room: Macdonald Foyer


Saturday, April 16 | 11:15AM - 11:15AM
On Own for Lunch


Saturday, April 16 | 12:30PM - 2:30PM
Workshop 3A: B Cell Lymphoma and Leukemia
Room: Macdonald D

Speaker 1 of 8
* Micah A. Luftig, Duke University Medical Center, USA
An ATM/Chk2 DNA Damage Response Suppresses EBV Mediated B Cell Transformation

Saturday, April 16 | 12:30PM - 2:30PM
Workshop 3A: B Cell Lymphoma and Leukemia
Room: Macdonald D

Speaker 2 of 8
Elizabeth Rose Walsh, NIAID, National Institutes of Health, USA
Requirements for B-T Cell Interactions in the Development of a TLR7 Transgenic Model of Systemic Autoimmune Disease

Saturday, April 16 | 12:30PM - 2:30PM
Workshop 3A: B Cell Lymphoma and Leukemia
Room: Macdonald D

Speaker 3 of 8
Casey D. Katerndahl, University of Minnesota, USA
A Pre-BCR/NF-kappaB Pathway Suppresses STAT5-dependent Pre-B Cell Leukemia

Saturday, April 16 | 12:30PM - 2:30PM
Workshop 3A: B Cell Lymphoma and Leukemia
Room: Macdonald D

Speaker 4 of 8
Joseph D. Dekker, University of Texas at Austin, USA
Investigating the Role of the Bcl11a Transcription Factor in Hematopoietic Development and Diffuse Large B Cell Lymphomas

Saturday, April 16 | 12:30PM - 2:30PM
Workshop 3A: B Cell Lymphoma and Leukemia
Room: Macdonald D

Speaker 5 of 8
* Arthur L. Shaffer III, NCI, National Institutes of Health, USA
The IRF4-SPIB Interface as a Therapeutic Target in Diffuse Large B-Cell Lymphoma

Saturday, April 16 | 12:30PM - 2:30PM
Workshop 3A: B Cell Lymphoma and Leukemia
Room: Macdonald D

Speaker 6 of 8
Nathalie Faumont, CNRS UMR 7276, France
Differential Weight and Function of RelA and RelB NF-kappaB Complexes in Both EBV-Transformed B-Cells and Activated B-Cell-Like Diffuse Large B-Cell Lymphomas

Saturday, April 16 | 12:30PM - 2:30PM
Workshop 3A: B Cell Lymphoma and Leukemia
Room: Macdonald D

Speaker 7 of 8
Michele Ceribelli, NCI, National Institutes of Health, USA
TCF4 Addiction in Activated B-Cell Like Diffuse Large B-Cell Lymphomas

Saturday, April 16 | 12:30PM - 2:30PM
Workshop 3A: B Cell Lymphoma and Leukemia
Room: Macdonald D

Speaker 8 of 8
Albert Gutierrez, Mayo Clinic College of Medicine, USA
CLL Lymph Node Proliferation Centers: A Role for BCR Signaling

Saturday, April 16 | 12:30PM - 2:30PM
Workshop 3B: B Cell Activation and Homeostasis
Room: MacDonald EF

Speaker 1 of 9
* Aaron J. Marshall, University of Manitoba, Canada

Saturday, April 16 | 12:30PM - 2:30PM
Workshop 3B: B Cell Activation and Homeostasis
Room: MacDonald EF

Speaker 2 of 9
* Lars Nitschke, University of Erlangen, Germany
Regulation of B Cell Activation by Inhibitory Receptors and the Adaptor Protein Grb2

Saturday, April 16 | 12:30PM - 2:30PM
Workshop 3B: B Cell Activation and Homeostasis
Room: MacDonald EF

Speaker 3 of 9
Marion Lösing, University of Goettingen, Germany
The Dok-3/Grb2 Module Accentuates Negative Regulatory Functions of Lyn in Antigen-Activated B Cells

Saturday, April 16 | 12:30PM - 2:30PM
Workshop 3B: B Cell Activation and Homeostasis
Room: MacDonald EF

Speaker 4 of 9
Berit Jungnickel, Friedrich Schiller University Jena, Germany
A Critical Role for p53 in the Germinal Center Reaction

Saturday, April 16 | 12:30PM - 2:30PM
Workshop 3B: B Cell Activation and Homeostasis
Room: MacDonald EF

Speaker 5 of 9
Ivan P. Landego, University of Manitoba, Canada
Role of TAPP-PI(3,4)P2 Interactions in B Cell Activation and Differentiation

Saturday, April 16 | 12:30PM - 2:30PM
Workshop 3B: B Cell Activation and Homeostasis
Room: MacDonald EF

Speaker 6 of 9
Vivian M. Turner, Garvan Institute, Australia
The Role of TRAF2, TRAF3, cIAP1 and cIAP2 during Early and Late Antigen-Specific B Cell Responses

Saturday, April 16 | 12:30PM - 2:30PM
Workshop 3B: B Cell Activation and Homeostasis
Room: MacDonald EF

Speaker 7 of 9
Yuanyuan Chu, Max Planck Institute of Biochemistry, Germany
B Cells Lacking the Tumor Suppressor TNFAIP3/A20 Display Impaired Differentiation, Hyperactivation and Cause Inflammation and Autoimmunity in Aged Mice

Saturday, April 16 | 12:30PM - 2:30PM
Workshop 3B: B Cell Activation and Homeostasis
Room: MacDonald EF

Speaker 8 of 9
Rebecca Winkelmann, Nikolaus-Fiebiger Center for Molecular Medicine, Germany
B Cell Homeostasis and Plasma Cell Homing Controlled by Krüppel-Like Factor 2

Saturday, April 16 | 12:30PM - 2:30PM
Workshop 3B: B Cell Activation and Homeostasis
Room: MacDonald EF

Speaker 9 of 9
Kristen L. Hoek, Vanderbilt University, USA
Follicular B Cell Trafficking Within the Spleen Actively Restricts Humoral Immune Responses

Saturday, April 16 | 2:30PM - 4:30PM
Workshop 3C: Memory B Cells and Modeling B Cell Responses
Room: MacDonald EF

Speaker 1 of 9
* Menno C. van Zelm, Monash University, Australia

Saturday, April 16 | 2:30PM - 4:30PM
Workshop 3C: Memory B Cells and Modeling B Cell Responses
Room: MacDonald EF

Speaker 2 of 9
* Leonore A. Herzenberg, Stanford University, USA
Antigen-Specific Memory in B-1a: A New Take on the Sources of Natural Antibody Production

Saturday, April 16 | 2:30PM - 4:30PM
Workshop 3C: Memory B Cells and Modeling B Cell Responses
Room: MacDonald EF

Speaker 3 of 9
Andrew L. Rankin, FivePrime, USA
IL-21R is Necessary for Normal Development of the Memory B Cell Response

Saturday, April 16 | 2:30PM - 4:30PM
Workshop 3C: Memory B Cells and Modeling B Cell Responses
Room: MacDonald EF

Speaker 4 of 9
Sandra Weller, Faculte de Medecine Necker-Enfants Malades, France
IgM+IgD+CD27+ B Cells Development and/or Homeostasis Requires IRAK4-Myd88 Dependent but TLR9-Independent Signals in Humans

Saturday, April 16 | 2:30PM - 4:30PM
Workshop 3C: Memory B Cells and Modeling B Cell Responses
Room: MacDonald EF

Speaker 5 of 9
Magdalena A. Berkowska, Leiden University Medical Center, Netherlands
Novel Insights into Germinal Center-Dependent and
–Independent Maturation Pathways by Molecular Analysis of Human Memory B-Cell Subsets


Saturday, April 16 | 2:30PM - 4:30PM
Workshop 3C: Memory B Cells and Modeling B Cell Responses
Room: MacDonald EF

Speaker 6 of 9
* Deborah Dunn-Walters, University of Surrey, UK
High Throughput Immunoglobulin Repertoire Analysis Distinguishes between Human IgM Memory and Switched Memory B Cell Populations

Saturday, April 16 | 2:30PM - 4:30PM
Workshop 3C: Memory B Cells and Modeling B Cell Responses
Room: MacDonald EF

Speaker 7 of 9
George Georgiou, University of Texas at Austin, USA
System-Level Organization and Dynamics of B cell Responses as Revealed by NextGen Sequencing of V Repertoires from B Lymphocytes Subpopulations in Healthy and Diseased Individuals

Saturday, April 16 | 2:30PM - 4:30PM
Workshop 3C: Memory B Cells and Modeling B Cell Responses
Room: MacDonald EF

Speaker 8 of 9
Justin J. Taylor, Fred Hutchinson Cancer Research Center, USA
Prolonged G1-Arrest Precedes Quiescence during Memory B Cell Differentiation

Saturday, April 16 | 2:30PM - 4:30PM
Workshop 3C: Memory B Cells and Modeling B Cell Responses
Room: MacDonald EF

Speaker 9 of 9
Jamie L. Duke, Yale University, USA
Computational Analysis of Genome-Wide Somatic Hypermutation

Saturday, April 16 | 4:30PM - 5:00PM
Coffee Available
Room: Macdonald Foyer


Saturday, April 16 | 5:00PM - 7:00PM
Manipulation of B Cells in Human Disease
Room: Macdonald D E F

Speaker 1 of 5
* Frances E. Lund, University of Alabama at Birmingham, USA

Saturday, April 16 | 5:00PM - 7:00PM
Manipulation of B Cells in Human Disease
Room: Macdonald D E F

Speaker 2 of 5
Anne Davidson, Feinstein Institute for Medical Research, USA
BAFF Inhibition in SLE

Saturday, April 16 | 5:00PM - 7:00PM
Manipulation of B Cells in Human Disease
Room: Macdonald D E F

Speaker 3 of 5
Susan Moir, NIAID, National Institutes of Health, USA
Immunopathogenesis of B Cells in HIV Infection

Saturday, April 16 | 5:00PM - 7:00PM
Manipulation of B Cells in Human Disease
Room: Macdonald D E F

Speaker 4 of 5
Jason Ho, NIAID, National Institutes of Health, USA
Short Talk:

Saturday, April 16 | 5:00PM - 7:00PM
Manipulation of B Cells in Human Disease
Room: Macdonald D E F

Speaker 5 of 5
Patrick C. Wilson, University of Chicago, USA
The Human B Cell Response to Annual and H1N1 Influenza Virus

Saturday, April 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Macdonald A B C


Saturday, April 16 | 8:00PM - 11:00PM
Entertainment
Room: Macdonald A B C


Saturday, April 16 | 8:00PM - 11:00PM
Cash Bar
Room: Macdonald A B C


Sunday, April 17 | 10:25AM - 10:25AM
Departure


*Session Chair.