Web Desc
Omics Meets Cell Biology
Organizer(s): Anne-Claude Gavin and Charlie M. Boone
Date: May 08 - 13, 2011
Location: Alpbach Congress Centrum, Alpbach, Austria
Supported by the Directors' Fund
Summary of Meeting:
Whole genome sequencing has become widespread and modern biologists currently access exponentially growing lists of genomes from organisms covering all three domains of life. This has fundamentally changed the way scientists address biological questions. A spectacular flourishing of technologies allows for global interrogation of gene activity and function and ever more comprehensive measurement of cellular macromolecules. These Omics approaches are still in full expansion but already increasingly contribute to the editing and annotation of systems-level networks charting physical and functional links between all cellular components. Nevertheless, an important challenge resides in the interpretation and integration of the data within the context of the whole physiology of a cell. We are for example, still learning and developing the bioinformatic tools to store and integrate different types of datasets. Emerging biochemical and chemical approaches contribute chemical tools and affinity reagents to systematically interrogate or perturb macromolecules within a cell. Live-cell imaging and quantitative microscopy have also moved large-scale allowing unprecedented phenotypic analysis. This conference will bring together the leading experts representing Omics technologies, cell biology, chemical-genetics, and bioinformatics to discuss and present these latest developments.
Scholarship Deadline: January 6 2011
Discounted Abstract Deadline: January 6 2011
Abstract Deadline: February 10 2011
Discounted Registration Deadline: March 8 2011
We gratefully acknowledge additional support for this conference from:
Boehringer Ingelheim Pharmaceuticals, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Science Foundation (NSF)
Grant No. MCB-1110372
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, May 08 | 3:00PM - 7:30PM
Registration
Room: Otto Molden Foyer


Sunday, May 08 | 6:15PM - 7:15PM
Refreshments
Room: Otto Molden Foyer


Sunday, May 08 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Erwin Schrödinger Hall

Speaker 1 of 1
Lucas Pelkmans, University of Zürich, Switzerland
Origins of Regulated Cell-to-Cell Variability

Monday, May 09 | 7:00AM - 8:00AM
Breakfast
Room: Your Lodging Location


Monday, May 09 | 8:00AM - 11:15AM
Proteome Visualization: Toward a Molecular Anatomy of the Ce
ll

Room: Erwin Schrödinger Hall

Speaker 1 of 7
* † Matthias Mann, Max Planck Institute of Biochemistry, Germany

Monday, May 09 | 8:00AM - 11:15AM
Proteome Visualization: Toward a Molecular Anatomy of the Ce
ll

Room: Erwin Schrödinger Hall

Speaker 2 of 7
Martin Beck, European Molecular Biology Laboratory, Germany
Molecular Anatomy of the Human Pathogen Leptospira interrogans

Monday, May 09 | 8:00AM - 11:15AM
Proteome Visualization: Toward a Molecular Anatomy of the Ce
ll

Room: Erwin Schrödinger Hall

Speaker 3 of 7
Robert B. Russell, University of Heidelberg, Germany
Predicting Protein-Peptide and Protein-Chemical Interactions within Biological Networks

Monday, May 09 | 8:00AM - 11:15AM
Proteome Visualization: Toward a Molecular Anatomy of the Ce
ll

Room: Erwin Schrödinger Hall

Speaker 4 of 7
Carol V. Robinson, University of Oxford, UK
Dehydrated but Unharmed? - The Mass Spectrometry of Protein Complexes

Monday, May 09 | 8:00AM - 11:15AM
Proteome Visualization: Toward a Molecular Anatomy of the Ce
ll

Room: Erwin Schrödinger Hall

Speaker 5 of 7
Frank Sobott, University of Antwerp, Belgium
Short Talk: Stoichiometry and Architecture of Protein-DNA/RNA Complexes by Native Mass Spectrometry Combined with Ion Mobility

Monday, May 09 | 8:00AM - 11:15AM
Proteome Visualization: Toward a Molecular Anatomy of the Ce
ll

Room: Erwin Schrödinger Hall

Speaker 6 of 7
Sarah Teichmann, Wellcome Sanger Institute, UK
Evolution and Assembly of Protein Complexes

Monday, May 09 | 8:00AM - 11:15AM
Proteome Visualization: Toward a Molecular Anatomy of the Ce
ll

Room: Erwin Schrödinger Hall

Speaker 7 of 7
Jennifer L. Greene, University of Pennsylvania, USA
Short Talk: Global Proteomic Approaches Reveal Structural Diversity of Cysteines Endogenously Targeted for S-Nitrosylation

Monday, May 09 | 9:20AM - 9:40AM
Coffee Break
Room: Otto Molden Foyer


Monday, May 09 | 11:15AM - 1:00PM
Poster Setup
Room: Otto Molden Foyer


Monday, May 09 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, May 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Otto Molden Foyer


Monday, May 09 | 2:30PM - 4:30PM
Workshop 1: Available Bioinformatic Resources for Cell Biolo
gists
Room: Erwin Schrödinger Hall

Speaker 1 of 7
* Lydie Lane, Swiss Institute of Bioinformatics, Switzerland
neXtProt, a Novel Human Protein Knowledge Platform in the Era of Omics Techologies

Monday, May 09 | 2:30PM - 4:30PM
Workshop 1: Available Bioinformatic Resources for Cell Biolo
gists
Room: Erwin Schrödinger Hall

Speaker 2 of 7
Mikhail Savitski, European Molecular Biology Laboratory, Germany
C-score, a Confidence Score for Reliable Protein Complex Determination from Orthogonal, High-Precision Quantitative Mass Spectrometry Experiments

Monday, May 09 | 2:30PM - 4:30PM
Workshop 1: Available Bioinformatic Resources for Cell Biolo
gists
Room: Erwin Schrödinger Hall

Speaker 3 of 7
Jean M. Peccoud, Virginia Tech, USA
Cyber-Infrastructures for Genetic Design Automation

Monday, May 09 | 2:30PM - 4:30PM
Workshop 1: Available Bioinformatic Resources for Cell Biolo
gists
Room: Erwin Schrödinger Hall

Speaker 4 of 7
Paul A. Jensen, University of Virginia, USA
Automatic Thresholding of Expression Data Captures Functional Responses in Genome-Scale Metabolic Models

Monday, May 09 | 2:30PM - 4:30PM
Workshop 1: Available Bioinformatic Resources for Cell Biolo
gists
Room: Erwin Schrödinger Hall

Speaker 5 of 7
Noor Jailkhani, International Centre for Genetic Engineering and Biotechnology, India
Delineating Points of Vulnerability in Mitogen Activated Signaling Networks

Monday, May 09 | 2:30PM - 4:30PM
Workshop 1: Available Bioinformatic Resources for Cell Biolo
gists
Room: Erwin Schrödinger Hall

Speaker 6 of 7
Olga Vitek, Northeastern University, USA
Statistical Methods and Tools for Protein Quantification in Mass Spectrometry-Based Proteomics

Monday, May 09 | 2:30PM - 4:30PM
Workshop 1: Available Bioinformatic Resources for Cell Biolo
gists
Room: Erwin Schrödinger Hall

Speaker 7 of 7
Benoît Robisson, INSERM PACA, France
Detection of Multifunctional Proteins in Protein-Protein Interaction Networks

Monday, May 09 | 4:30PM - 5:00PM
Coffee Available
Room: Otto Molden Foyer


Monday, May 09 | 5:00PM - 7:00PM
Omics of Complex Systems
Room: Erwin Schrödinger Hall

Speaker 1 of 5
* Brenda J. Andrews, University of Toronto, Canada

Monday, May 09 | 5:00PM - 7:00PM
Omics of Complex Systems
Room: Erwin Schrödinger Hall

Speaker 2 of 5
Jeff Hasty, University of California, San Diego, USA
Genetic Clocks from Engineered Oscillators

Monday, May 09 | 5:00PM - 7:00PM
Omics of Complex Systems
Room: Erwin Schrödinger Hall

Speaker 3 of 5
Norbert Perrimon, Harvard Medical School, USA
Large-Scale Analyses of Signaling Networks

Monday, May 09 | 5:00PM - 7:00PM
Omics of Complex Systems
Room: Erwin Schrödinger Hall

Speaker 4 of 5
Mikko Taipale, Whitehead Institute, USA
Short Talk: High-Throughput in vivo Profiling of Kinase/HSP90 Interactions and Kinase Inhibitor Specificities

Monday, May 09 | 5:00PM - 7:00PM
Omics of Complex Systems
Room: Erwin Schrödinger Hall

Speaker 5 of 5
Joachim Wittbrodt, Heidelberg University, Germany
Seeing is Believing: From the Digital Embryo to Refined Stem Cells (and more)

Monday, May 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Otto Molden Foyer


Monday, May 09 | 7:30PM - 10:00PM
Poster Session 1
Room: Otto Molden Foyer


Tuesday, May 10 | 7:00AM - 8:00AM
Breakfast
Room: Your Lodging Location


Tuesday, May 10 | 8:00AM - 11:00AM
Omics and Signaling
Room: Erwin Schrödinger Hall

Speaker 1 of 7
* Norbert Perrimon, Harvard Medical School, USA

Tuesday, May 10 | 8:00AM - 11:00AM
Omics and Signaling
Room: Erwin Schrödinger Hall

Speaker 2 of 7
Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zürich, Switzerland
Mass Spectrometric Collection of Proteomic and Phosphoproteomic Data for Systems Biology

Tuesday, May 10 | 8:00AM - 11:00AM
Omics and Signaling
Room: Erwin Schrödinger Hall

Speaker 3 of 7
Rochelle C. J. D'Souza, Max Planck Institute of Biochemistry, Germany
Short Talk: Studying TGF-beta Signaling using a High Resolution, Quantitative Mass Spectrometric Approach

Tuesday, May 10 | 8:00AM - 11:00AM
Omics and Signaling
Room: Erwin Schrödinger Hall

Speaker 4 of 7
Andrew Fraser, University of Toronto, Canada
Short Talk: Measuring Fitness in an Animal Model

Tuesday, May 10 | 8:00AM - 11:00AM
Omics and Signaling
Room: Erwin Schrödinger Hall

Speaker 5 of 7
Matthias Mann, Max Planck Institute of Biochemistry, Germany
Technologies for Comprehensive Proteome Quantification

Tuesday, May 10 | 8:00AM - 11:00AM
Omics and Signaling
Room: Erwin Schrödinger Hall

Speaker 6 of 7
Anne-Claude Gavin, European Molecular Biology Laboratory, Germany
Molecular Networks from Proteins to Metabolites

Tuesday, May 10 | 8:00AM - 11:00AM
Omics and Signaling
Room: Erwin Schrödinger Hall

Speaker 7 of 7
Julian Mintseris, Harvard Medical School, USA
Short Talk: The Drosophila Melanogaster Protein Interaction Map

Tuesday, May 10 | 9:20AM - 9:40AM
Coffee Break
Room: Otto Molden Foyer


Tuesday, May 10 | 11:15AM - 1:00PM
Poster Setup
Room: Otto Molden Foyer


Tuesday, May 10 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, May 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Otto Molden Foyer


Tuesday, May 10 | 4:30PM - 5:00PM
Coffee Available
Room: Otto Molden Foyer


Tuesday, May 10 | 5:00PM - 7:00PM
Omics of Metabolic Networks
Room: Erwin Schrödinger Hall

Speaker 1 of 5
* Lucas Pelkmans, University of Zürich, Switzerland

Tuesday, May 10 | 5:00PM - 7:00PM
Omics of Metabolic Networks
Room: Erwin Schrödinger Hall

Speaker 2 of 5
Nick M. Luscombe, EMBL-European Bioinformatics Institute, UK
Models to Predict Gene Regulation in Three Dimensions

Tuesday, May 10 | 5:00PM - 7:00PM
Omics of Metabolic Networks
Room: Erwin Schrödinger Hall

Speaker 3 of 5
Uwe Sauer, Institute of Molecular Systems Biology, ETH Zurich, Switzerland
Unraveling Active Metabolic Regulation Networks by Omics Methods

Tuesday, May 10 | 5:00PM - 7:00PM
Omics of Metabolic Networks
Room: Erwin Schrödinger Hall

Speaker 4 of 5
Igor Stagljar, University of Toronto, Canada
Protein Interaction Networks Regulating Cell Signaling in Human Health and Disease

Tuesday, May 10 | 5:00PM - 7:00PM
Omics of Metabolic Networks
Room: Erwin Schrödinger Hall

Speaker 5 of 5
Nicola Zamboni, Institute of Molecular Systems Biology, Switzerland
Short Talk: Metabotyping of Breast Cancer by High throughput Metabolomics

Tuesday, May 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Otto Molden Foyer


Tuesday, May 10 | 7:30PM - 10:00PM
Poster Session 2
Room: Otto Molden Foyer


Wednesday, May 11 | 7:00AM - 8:00AM
Breakfast
Room: Your Lodging Location


Wednesday, May 11 | 8:00AM - 11:15AM
From Omics to Phenomes I
Room: Erwin Schrödinger Hall

Speaker 1 of 8
* Yoshikazu Ohya, University of Tokyo, Japan

Wednesday, May 11 | 8:00AM - 11:15AM
From Omics to Phenomes I
Room: Erwin Schrödinger Hall

Speaker 2 of 8
Brenda J. Andrews, University of Toronto, Canada
Global Protein Abundance and Localization Maps Define Subcellular Flux Networks in Yeast

Wednesday, May 11 | 8:00AM - 11:15AM
From Omics to Phenomes I
Room: Erwin Schrödinger Hall

Speaker 3 of 8
Fabio Piano, New York University, USA
Toward a Comprehensive Molecular Description of Early Embryogenesis in C. elegans

Wednesday, May 11 | 8:00AM - 11:15AM
From Omics to Phenomes I
Room: Erwin Schrödinger Hall

Speaker 4 of 8
Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute, Canada
Protein Phosphatase Networks

Wednesday, May 11 | 8:00AM - 11:15AM
From Omics to Phenomes I
Room: Erwin Schrödinger Hall

Speaker 5 of 8
Susann Lehmann, University of Nottingham, UK
Short Talk: Identification of Kinases and Phosphatases Regulating Muscle Protein Degradation and Dystrophies in C. elegans by a Genome-Wide RNAi Screen

Wednesday, May 11 | 8:00AM - 11:15AM
From Omics to Phenomes I
Room: Erwin Schrödinger Hall

Speaker 6 of 8
Lorey K. Smith, Peter MacCallum Cancer Centre, Australia
Short Talk: A Large Scale RNAi Screen Identifies an Extensive Network of Mammalian Cell Polarity Regulators as Key Modifiers of the Oncogenic Properties of Sustained RAS-MAPK Signaling

Wednesday, May 11 | 8:00AM - 11:15AM
From Omics to Phenomes I
Room: Erwin Schrödinger Hall

Speaker 7 of 8
Nils Johnsson, Ulm University, Germany
Short Talk: Constructing and Exploiting Constraint Interaction Networks for Understanding Cellular Processes

Wednesday, May 11 | 8:00AM - 11:15AM
From Omics to Phenomes I
Room: Erwin Schrödinger Hall

Speaker 8 of 8
Thomas Kislinger, University of Toronto, Canada
Short Talk: Identification of Cell-Surface Proteins Enables Isolation of
Viable Lineage-Specific Cells from Blastocysts by Flow Cytometry


Wednesday, May 11 | 9:20AM - 9:40AM
Coffee Break
Room: Otto Molden Foyer


Wednesday, May 11 | 11:15AM - 1:00PM
Poster Setup
Room: Otto Molden Foyer


Wednesday, May 11 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, May 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Otto Molden Foyer


Wednesday, May 11 | 4:30PM - 5:00PM
Coffee Available
Room: Otto Molden Foyer


Wednesday, May 11 | 5:00PM - 7:15PM
From Omics to Phenomes II
Room: Erwin Schrödinger Hall

Speaker 1 of 6
* Joseph Lehár, Novartis Institutes for BioMedical Research, USA

Wednesday, May 11 | 5:00PM - 7:15PM
From Omics to Phenomes II
Room: Erwin Schrödinger Hall

Speaker 2 of 6
Yoshikazu Ohya, University of Tokyo, Japan
Hi-Content and Quantitative Morphological Screening for the Drug Targets in Yeast

Wednesday, May 11 | 5:00PM - 7:15PM
From Omics to Phenomes II
Room: Erwin Schrödinger Hall

Speaker 3 of 6
A.J. Marian Walhout, University of Massachusetts Medical School, USA
Gene-Centered Regulatory Networks

Wednesday, May 11 | 5:00PM - 7:15PM
From Omics to Phenomes II
Room: Erwin Schrödinger Hall

Speaker 4 of 6
Jan Ellenberg, European Molecular Biology Laboratory, Germany
Automating Fluorescence Microscopy for Systems Biology: From Genome-Wide Profiling to the Analysis of Protein Complexes

Wednesday, May 11 | 5:00PM - 7:15PM
From Omics to Phenomes II
Room: Erwin Schrödinger Hall

Speaker 5 of 6
Alexander S. Mikheyev, Okinawa Institute of Science and Technology, Japan
Short Talk: Evolutionary Fate of Alien Genes in Bdelloid Rotifers

Wednesday, May 11 | 5:00PM - 7:15PM
From Omics to Phenomes II
Room: Erwin Schrödinger Hall

Speaker 6 of 6
Rekha G. Panchal, U.S. Army Medical Research Institute of Infectious Diseases, USA
Short Talk: Systems Cell Biology to Profile Cellular and Pathogen Responses to Bioactive Probes based on High Content Screening

Wednesday, May 11 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Otto Molden Foyer


Wednesday, May 11 | 7:30PM - 10:00PM
Poster Session 3
Room: Otto Molden Foyer


Thursday, May 12 | 7:00AM - 8:00AM
Breakfast
Room: Your Lodging Location


Thursday, May 12 | 8:00AM - 11:15AM
Omics Meets Chemistry and Drug Discovery
Room: Erwin Schrödinger Hall

Speaker 1 of 7
* Marie Evangelista, Genentech, Inc., USA

Thursday, May 12 | 8:00AM - 11:15AM
Omics Meets Chemistry and Drug Discovery
Room: Erwin Schrödinger Hall

Speaker 2 of 7
Gitte Neubauer, Cellzome AG, Germany
Interrogating Drugs, their Targets and their Complexes: Chemical Proteomics in Drug Discovery

Thursday, May 12 | 8:00AM - 11:15AM
Omics Meets Chemistry and Drug Discovery
Room: Erwin Schrödinger Hall

Speaker 3 of 7
Minoru Yoshida, RIKEN, Japan
Reverse Proteomics Approaches for Discovery and Target Identification of Novel Bioactive Compounds

Thursday, May 12 | 8:00AM - 11:15AM
Omics Meets Chemistry and Drug Discovery
Room: Erwin Schrödinger Hall

Speaker 4 of 7
Joseph Lehár, Novartis Institutes for BioMedical Research, USA
Approaching Cancer Therapy via a Genomic, Phenotypic and Combination Campaign

Thursday, May 12 | 8:00AM - 11:15AM
Omics Meets Chemistry and Drug Discovery
Room: Erwin Schrödinger Hall

Speaker 5 of 7
Denis V. Yashin, Institute of Gene Biology RAS, Russia
Short Talk: Interplay of Three Proteins (PGRP S, Hsp70, and S100A4) in Host vs. Cancer Combat

Thursday, May 12 | 8:00AM - 11:15AM
Omics Meets Chemistry and Drug Discovery
Room: Erwin Schrödinger Hall

Speaker 6 of 7
Herbert Waldmann, Max Planck Institute for Molecular Physiology, Germany
From Molecular to Dynamic Biological Systems

Thursday, May 12 | 8:00AM - 11:15AM
Omics Meets Chemistry and Drug Discovery
Room: Erwin Schrödinger Hall

Speaker 7 of 7
Christoph Schaab, Kinaxo Biotechnologies, Germany
Short Talk: Comprehensive Phosphoproteomic Mode of Action Analysis in Cultured Cell Lines and Xenograft Models

Thursday, May 12 | 9:20AM - 9:40AM
Coffee Break
Room: Otto Molden Foyer


Thursday, May 12 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Thursday, May 12 | 4:30PM - 5:00PM
Coffee Available
Room: Otto Molden Foyer


Thursday, May 12 | 5:00PM - 7:15PM
Omics Meets Genetics and Gene Expression
Room: Erwin Schrödinger Hall

Speaker 1 of 6
* A.J. Marian Walhout, University of Massachusetts Medical School, USA

Thursday, May 12 | 5:00PM - 7:15PM
Omics Meets Genetics and Gene Expression
Room: Erwin Schrödinger Hall

Speaker 2 of 6
Charlie M. Boone, University of Toronto, Canada
The Genetic Landscape of a Cell

Thursday, May 12 | 5:00PM - 7:15PM
Omics Meets Genetics and Gene Expression
Room: Erwin Schrödinger Hall

Speaker 3 of 6
Martin Fussenegger, ETH Zürich, Switzerland
Engineering Synthetic Mammalian Gene Networks: From Tools to Therapies

Thursday, May 12 | 5:00PM - 7:15PM
Omics Meets Genetics and Gene Expression
Room: Erwin Schrödinger Hall

Speaker 4 of 6
Marie Evangelista, Genentech, Inc., USA
Integration of Genomic Strategies to Predict Combination Benefit in the Clinic

Thursday, May 12 | 5:00PM - 7:15PM
Omics Meets Genetics and Gene Expression
Room: Erwin Schrödinger Hall

Speaker 5 of 6
Christian Feller, ETH Zurich, Switzerland
Short Talk: MOF Associated Cofactors Confer Different Modes of Transcriptional Activation

Thursday, May 12 | 5:00PM - 7:15PM
Omics Meets Genetics and Gene Expression
Room: Erwin Schrödinger Hall

Speaker 6 of 6
Florian Grebien, CeMM - Research Center for Molecular Medicine, Austria
Short Talk: Genomic and Proteomic Characterization of Normal and Oncogenic CEBPA Variants in Myeloid Cells

Thursday, May 12 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Otto Molden Foyer


Thursday, May 12 | 8:00PM - 11:00PM
Entertainment
Room: Otto Molden Foyer


Thursday, May 12 | 8:00PM - 11:00PM
Cash Bar
Room: Otto Molden Foyer


Friday, May 13 | 10:25AM - 10:25AM
Departure


*Session Chair.