Web Desc
Lipid Biology and Lipotoxicity
Organizer(s): Scott A. Summers and Rudolf Zechner
Date: May 15 - 20, 2011
Location: INEC Killarney Convention Centre, Killarney, Co. Kerry, Ireland
Organized in Collaboration with Science Foundation Ireland
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Summary of Meeting:
The accumulation of fat in tissues not suited for lipid storage has deleterious consequences on organ function, leading to cellular damage that underlies diabetes, heart disease, and hypertension. Illustrating the relationship is the fact that numerous effective therapeutics ameliorate metabolic disease symptoms by limiting the inappropriate deposition of fat in peripheral tissues (e.g. thiazolidinediones, metformin, or statins). Recent advances in genomics and lipidomics offer researchers an opportunity to make a substantial leap in the understanding and treatment of pathogenic conditions resulting from the excessive production and/or underutilization of fat. This meeting reviews these areas, placing specific emphasis on the following: (a) relationships between ectopic lipid deposition and metabolic disease; (b) mechanisms through which lipid excess alter tissue function; (c) regulatory processes that control lipid storage and metabolism; and (d) technological advances in the area of lipid analysis (i.e. lipidomics).
Scholarship Deadline: January 13 2011
Discounted Abstract Deadline: January 13 2011
Abstract Deadline: February 15 2011
Discounted Registration Deadline: March 15 2011
We gratefully acknowledge additional support for this conference from:
Avanti Polar Lipids, Inc.Fáilte Ireland
Journal of Lipid Research
Science Foundation Ireland
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL108500-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, May 15 | 3:00PM - 7:30PM
Registration
Room: INEC Conference Centre Foyer


Sunday, May 15 | 6:15PM - 7:15PM
Refreshments
Room: INEC Conference Centre Foyer


Sunday, May 15 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: INEC Main Auditorium

Speaker 1 of 2
* Scott A. Summers, University of Utah, USA

Sunday, May 15 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: INEC Main Auditorium

Speaker 2 of 2
Roger H. Unger, University of Texas Southwestern Medical Center, USA
Origins of the Lipotoxicity Hypothesis: Implications for Human Disease

Monday, May 16 | 8:00AM - 9:00AM
Breakfast
Room: INEC Conference Centre Foyer


Monday, May 16 | 9:00AM - 12:00PM
Ectopic Lipid Accumulation and Disease
Room: INEC Main Auditorium

Speaker 1 of 6
* Gregory J. Cooney, University of Sydney, Australia

Monday, May 16 | 9:00AM - 12:00PM
Ectopic Lipid Accumulation and Disease
Room: INEC Main Auditorium

Speaker 2 of 6
Antonio J. Vidal-Puig, University of Cambridge, UK
Adipose tissue expandability, lipotoxicity and the Metabolic syndrome

Monday, May 16 | 9:00AM - 12:00PM
Ectopic Lipid Accumulation and Disease
Room: INEC Main Auditorium

Speaker 3 of 6
Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA
Tissue-Specific Deficiencies of Acyl-CoA Synthetase-1 in Mice

Monday, May 16 | 9:00AM - 12:00PM
Ectopic Lipid Accumulation and Disease
Room: INEC Main Auditorium

Speaker 4 of 6
Matej Orešic, Steno Diabetes Center, Denmark
Lipidomic Analysis of Metabolic Disease

Monday, May 16 | 9:00AM - 12:00PM
Ectopic Lipid Accumulation and Disease
Room: INEC Main Auditorium

Speaker 5 of 6
Jens C. Brüning, Max Planck Institute for Metabolism Research, Germany
Role of FTO in Obesity

Monday, May 16 | 9:00AM - 12:00PM
Ectopic Lipid Accumulation and Disease
Room: INEC Main Auditorium

Speaker 6 of 6
Gos Micklem, University of Cambridge, UK
Short Talk: metabolicMine: An Integrated Web Resource of Data & Tools to Support the Common Metabolic Disease Research Community

Monday, May 16 | 10:20AM - 10:40AM
Coffee Break
Room: INEC Confenece Centre Foyer


Monday, May 16 | 12:00PM - 1:00PM
Poster Setup
Room: INEC Conference Centre Foyer


Monday, May 16 | 12:00PM - 12:00PM
On Own for Lunch and Recreation


Monday, May 16 | 1:00PM - 10:00PM
Poster Viewing
Room: INEC Conference Centre Foyer


Monday, May 16 | 4:30PM - 5:00PM
Coffee Available
Room: INEC Conference Centre Foyer


Monday, May 16 | 5:00PM - 7:15PM
Fatty Liver/NASH
Room: INEC Main Auditorium

Speaker 1 of 6
* Michael Trauner, Medical University of Vienna, Austria

Monday, May 16 | 5:00PM - 7:15PM
Fatty Liver/NASH
Room: INEC Main Auditorium

Speaker 2 of 6
Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Adipokines, Mitochondrial Function and Fatty Liver

Monday, May 16 | 5:00PM - 7:15PM
Fatty Liver/NASH
Room: INEC Main Auditorium

Speaker 3 of 6
Catherine Postic, INSERM, Institut Cochin, France
The Transcription Factor ChREBP and Hepatic Steatosis

Monday, May 16 | 5:00PM - 7:15PM
Fatty Liver/NASH
Room: INEC Main Auditorium

Speaker 4 of 6
Anil K. Agarwal, University of Texas Southwestern Medical Center, USA
Lipodystrophy and Hepatic Steatosis Due to Agpat2 Deficiency

Monday, May 16 | 5:00PM - 7:15PM
Fatty Liver/NASH
Room: INEC Main Auditorium

Speaker 5 of 6
Jared Rutter, University of Utah, USA
Short Talk: Signal Integration to Control Lipid Metabolism

Monday, May 16 | 5:00PM - 7:15PM
Fatty Liver/NASH
Room: INEC Main Auditorium

Speaker 6 of 6
Patricia C. Chui, Beth Israel Deaconess Medical Center, USA
Short Talk: Fibroblast Growth Factor 21 Plays a Critical and Protective Role in the Development of Steatohepatitis

Monday, May 16 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: INEC Conference Centre Foyer


Monday, May 16 | 7:30PM - 10:00PM
Poster Session 1
Room: INEC Conference Centre Foyer


Tuesday, May 17 | 8:00AM - 9:00AM
Breakfast
Room: INEC Conference Centre Foyer


Tuesday, May 17 | 9:00AM - 12:00PM
Lipid-Induced Insulin Resistance
Room: INEC Main Auditorium

Speaker 1 of 6
* Carsten Schmitz-Peiffer, Garvan Institute of Medical Research, Australia

Tuesday, May 17 | 9:00AM - 12:00PM
Lipid-Induced Insulin Resistance
Room: INEC Main Auditorium

Speaker 2 of 6
Deborah M. Muoio, Duke University Medical Center, USA
Incomplete Lipid Oxidation and Insulin Resistance in Skeletal Muscle

Tuesday, May 17 | 9:00AM - 12:00PM
Lipid-Induced Insulin Resistance
Room: INEC Main Auditorium

Speaker 3 of 6
Mark A. Febbraio, Monash Institute of Pharmaceutical Sciences, Australia
Regulation of Lipid-Induced Inflammation in Macrophages: Role in Obesity-Induced Insulin Resistance

Tuesday, May 17 | 9:00AM - 12:00PM
Lipid-Induced Insulin Resistance
Room: INEC Main Auditorium

Speaker 4 of 6
Karen Reue, University of California, Los Angeles, USA
Lipin-1 and Protection from Muscle Lipotoxicity

Tuesday, May 17 | 9:00AM - 12:00PM
Lipid-Induced Insulin Resistance
Room: INEC Main Auditorium

Speaker 5 of 6
Scott A. Summers, University of Utah, USA
A Role for Ceramides at the Nexus of Inflammation and Metabolic Diseases

Tuesday, May 17 | 9:00AM - 12:00PM
Lipid-Induced Insulin Resistance
Room: INEC Main Auditorium

Speaker 6 of 6
Caleb Lord, University of Texas Southwestern Medical Center, USA
Short Talk: CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action

Tuesday, May 17 | 10:20AM - 10:40AM
Coffee Break
Room: INEC Confenece Centre Foyer


Tuesday, May 17 | 12:00PM - 1:00PM
Poster Setup
Room: INEC Conference Centre Foyer


Tuesday, May 17 | 12:00PM - 12:00PM
On Own for Lunch and Recreation


Tuesday, May 17 | 1:00PM - 10:00PM
Poster Viewing
Room: INEC Conference Centre Foyer


Tuesday, May 17 | 4:30PM - 5:00PM
Coffee Available
Room: INEC Conference Centre Foyer


Tuesday, May 17 | 5:00PM - 7:15PM
Lipid Hydrolysis and Oxidation
Room: INEC Main Auditorium

Speaker 1 of 6
* Richard Lehner, University of Alberta, Canada

Tuesday, May 17 | 5:00PM - 7:15PM
Lipid Hydrolysis and Oxidation
Room: INEC Main Auditorium

Speaker 2 of 6
Rudolf Zechner, University of Graz, Austria
ATGL (PNPLA2) and Adiponutrin (PNPLA3): Closely Related Enzymes with Different Functions

Tuesday, May 17 | 5:00PM - 7:15PM
Lipid Hydrolysis and Oxidation
Room: INEC Main Auditorium

Speaker 3 of 6
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Autophagy and Lipid Catabolism

Tuesday, May 17 | 5:00PM - 7:15PM
Lipid Hydrolysis and Oxidation
Room: INEC Main Auditorium

Speaker 4 of 6
Richard Roy, McGill University, Canada
Genes that Affect Lipid Storage and Hydrolysis in Response to Energy/Environmental Stress

Tuesday, May 17 | 5:00PM - 7:15PM
Lipid Hydrolysis and Oxidation
Room: INEC Main Auditorium

Speaker 5 of 6
Thomas Scherer, Mount Sinai School of Medicine, USA
Short Talk: Short–Term Overfeeding Disrupts Brain Insulin Control of Liver and Adipose Tissue Function

Tuesday, May 17 | 5:00PM - 7:15PM
Lipid Hydrolysis and Oxidation
Room: INEC Main Auditorium

Speaker 6 of 6
Takashi Osumi, University of Hyogo, Japan
Short Talk: Physiological Significance of Micro-Lipid Droplets and Intracellular Traffic of Lipid Droplet-Associated Proteins in Adipocyte Lipolysis

Tuesday, May 17 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: INEC Conference Centre Foyer


Tuesday, May 17 | 7:30PM - 10:00PM
Poster Session 2
Room: INEC Conference Centre Foyer


Wednesday, May 18 | 8:00AM - 9:00AM
Breakfast
Room: INEC Conference Centre Foyer


Wednesday, May 18 | 9:00AM - 12:00PM
Physiology of Lipid Droplet Formation
Room: INEC Main Auditorium

Speaker 1 of 6
* David B. Savage, University of Cambridge, UK

Wednesday, May 18 | 9:00AM - 12:00PM
Physiology of Lipid Droplet Formation
Room: INEC Main Auditorium

Speaker 2 of 6
Dawn L. Brasaemle, Rutgers University, USA
Perilipin Control of Lipolysis

Wednesday, May 18 | 9:00AM - 12:00PM
Physiology of Lipid Droplet Formation
Room: INEC Main Auditorium

Speaker 3 of 6
Robert G. Parton, University of Queensland, Australia
Cav-/- Mice are Resistant to Diet-induced Obesity

Wednesday, May 18 | 9:00AM - 12:00PM
Physiology of Lipid Droplet Formation
Room: INEC Main Auditorium

Speaker 4 of 6
Michael P. Czech, University of Massachusetts Medical School, USA
Lipid Droplet Proteins in the Control of Peripheral Insulin Sensitivity

Wednesday, May 18 | 9:00AM - 12:00PM
Physiology of Lipid Droplet Formation
Room: INEC Main Auditorium

Speaker 5 of 6
Ronald P. Kühnlein, Max-Planck-Institut für Biophysikalische Chemie, Germany
Lipid Droplet Proteins and Fat Storage in Flies

Wednesday, May 18 | 9:00AM - 12:00PM
Physiology of Lipid Droplet Formation
Room: INEC Main Auditorium

Speaker 6 of 6
Sheetal Gandotra, University of Cambridge, UK
Short Talk: Human Perilipin Deficiency is Associated with Partial Lipodystrophy, Hypertriglyceridaemia and Insulin Resistant Diabetes

Wednesday, May 18 | 10:20AM - 10:40AM
Coffee Break
Room: INEC Confenece Centre Foyer


Wednesday, May 18 | 12:00PM - 1:00PM
Poster Setup
Room: INEC Conference Centre Foyer


Wednesday, May 18 | 12:00PM - 12:00PM
On Own for Lunch and Recreation


Wednesday, May 18 | 1:00PM - 10:00PM
Poster Viewing
Room: INEC Conference Centre Foyer


Wednesday, May 18 | 4:30PM - 5:00PM
Coffee Available
Room: INEC Conference Centre Foyer


Wednesday, May 18 | 5:00PM - 7:30PM
Lipid Synthesis and Storage
Room: INEC Main Auditorium

Speaker 1 of 7
* Jacqueline M. Stephens, Louisiana State University, USA

Wednesday, May 18 | 5:00PM - 7:30PM
Lipid Synthesis and Storage
Room: INEC Main Auditorium

Speaker 2 of 7
Ira J. Goldberg, New York University, USA
Introduction to the Journal of Lipid Research Lectureship

Wednesday, May 18 | 5:00PM - 7:30PM
Lipid Synthesis and Storage
Room: INEC Main Auditorium

Speaker 3 of 7
Robert V. Farese Jr., Harvard School of Public Health, USA
Journal of Lipid Research Lecture: How Cells Fatten Up: Fat Synthesis and Lipid Droplets

Wednesday, May 18 | 5:00PM - 7:30PM
Lipid Synthesis and Storage
Room: INEC Main Auditorium

Speaker 4 of 7
Juleen R. Zierath, Karolinska Institutet, Sweden
Role of Diacylglycerol Kinase delta in Insulin Sensitivity and Energy

Wednesday, May 18 | 5:00PM - 7:30PM
Lipid Synthesis and Storage
Room: INEC Main Auditorium

Speaker 5 of 7
Morris J. Birnbaum, Pfizer Inc., USA
The Regulation of Hepatic Lipid Metabolism by Insulin

Wednesday, May 18 | 5:00PM - 7:30PM
Lipid Synthesis and Storage
Room: INEC Main Auditorium

Speaker 6 of 7
Ajay Chawla, Merck and University of California, San Francisco, USA
Short Talk: Macrophages and Brown Fat Metabolism

Wednesday, May 18 | 5:00PM - 7:30PM
Lipid Synthesis and Storage
Room: INEC Main Auditorium

Speaker 7 of 7
Joerg Heeren, University Medical Center Hamburg-Eppendorf, Germany
Short Talk: Activation of Brown Adipose Tissue is a Master Regulator of Systemic Triglyceride Metabolism

Wednesday, May 18 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: INEC Conference Centre Foyer


Wednesday, May 18 | 7:30PM - 10:00PM
Poster Session 3
Room: INEC Conference Centre Foyer


Thursday, May 19 | 8:00AM - 9:00AM
Breakfast
Room: INEC Conference Centre Foyer


Thursday, May 19 | 9:00AM - 12:00PM
Cardiovascular Complications of Lipotoxicity
Room: INEC Main Auditorium

Speaker 1 of 6
* Sander Kersten, Wageningen University, Netherlands

Thursday, May 19 | 9:00AM - 12:00PM
Cardiovascular Complications of Lipotoxicity
Room: INEC Main Auditorium

Speaker 2 of 6
E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Lipid-Induced Mitochondrial Dysfunction in the Heart

Thursday, May 19 | 9:00AM - 12:00PM
Cardiovascular Complications of Lipotoxicity
Room: INEC Main Auditorium

Speaker 3 of 6
Ira J. Goldberg, New York University, USA
Lipotoxicity in the Heart

Thursday, May 19 | 9:00AM - 12:00PM
Cardiovascular Complications of Lipotoxicity
Room: INEC Main Auditorium

Speaker 4 of 6
Jean E. Schaffer, Harvard University, USA
Unexpected Regulators of Metabolic Stress

Thursday, May 19 | 9:00AM - 12:00PM
Cardiovascular Complications of Lipotoxicity
Room: INEC Main Auditorium

Speaker 5 of 6
Gary D. Lopaschuk, University of Alberta, Canada
Contribution of Fatty Acid Oxidation to Lipotoxicity in the Heart

Thursday, May 19 | 9:00AM - 12:00PM
Cardiovascular Complications of Lipotoxicity
Room: INEC Main Auditorium

Speaker 6 of 6
Ebru Erbay, Bilkent University, Turkey
Short Talk: Nutritional Modification of Lipotoxic Endoplasmic Reticulum Stress and Inflammation by a Bioactive Lipokine Prevents Atherosclerosis

Thursday, May 19 | 10:20AM - 10:40AM
Coffee Break
Room: INEC Confenece Centre Foyer


Thursday, May 19 | 12:00PM - 12:00PM
On Own for Lunch and Recreation


Thursday, May 19 | 4:30PM - 5:00PM
Coffee Available
Room: INEC Conference Centre Foyer


Thursday, May 19 | 5:00PM - 7:00PM
Lipid Handling of Beta Cells
Room: INEC Main Auditorium

Speaker 1 of 5
* Kyle Hoehn, University of New South Wales, Australia

Thursday, May 19 | 5:00PM - 7:00PM
Lipid Handling of Beta Cells
Room: INEC Main Auditorium

Speaker 2 of 5
Marc Prentki, Montreal Diabetes Research Center, Canada
Glycerolipid/Fatty Acid Cycling and beta-Cell Signal Transduction in Health and Diabetes

Thursday, May 19 | 5:00PM - 7:00PM
Lipid Handling of Beta Cells
Room: INEC Main Auditorium

Speaker 3 of 5
Vincent Poitout, Montreal Diabetes Research Center, Canada
Glucolipodysfunction of the Pancreatic Beta Cell

Thursday, May 19 | 5:00PM - 7:00PM
Lipid Handling of Beta Cells
Room: INEC Main Auditorium

Speaker 4 of 5
Ernesto Bernal-Mizrachi, University of Miami Miller School of Medicine, USA
Nutrient Regulation of beta-Cell Mass

Thursday, May 19 | 5:00PM - 7:00PM
Lipid Handling of Beta Cells
Room: INEC Main Auditorium

Speaker 5 of 5
Trevor J. Biden, Garvan Institute of Medical Research, Australia
Short Talk: A Lipidomic Screen Links Ceramide with ER Stress in Pancreatic beta-Cell Lipotoxicity

Thursday, May 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: INEC Conference Centre Foyer


Thursday, May 19 | 8:00PM - 11:00PM
Entertainment
Room: INEC Conference Centre Foyer


Thursday, May 19 | 8:00PM - 11:00PM
Cash Bar
Room: INEC Conference Centre Foyer


Friday, May 20 | 10:22AM - 10:22AM
Departure


*Session Chair
†Invited, not yet responded.