Web Desc
Pathogenesis of Influenza: Virus-Host Interactions
Organizer(s): Siamon Gordon, Malik Peiris and Kanta Subbarao
Date: May 23 - 28, 2011
Location: Sheraton Hong Kong Hotel & Towers, Kowloon, Hong Kong, China
Organized in Collaboration with The University of Hong Kong as part of its Centenary Celebrations;
also made possible by an Area of Excellence in Influenza grant
funded by the University Grants Committee of Hong Kong
Summary of Meeting:
The mechanisms underlying the pathogenesis of influenza remain controversial. The direct cytopathic effects of viral replication, tissue tropism of the virus, viral-bacterial synergy, as well as innate host responses are inextricably linked and play roles to varying degrees in “seasonal,” zoonotic and pandemic influenza, examples being the pandemics of 1918 and 2009 and H5N1 avian influenza. Animal models, though indispensible, have significant limitations with regard to physiological relevance to human disease. The current symposium brings together researchers working on the virus, viral receptors and tissue tropism, innate and adaptive immunity, systems biology and clinical aspects of lung injury and host defense, to address questions on the pathogenesis of influenza. The aim will be to integrate data from animal and ex vivo / in vitro human experimental models as well as human disease to understand pathogenesis of influenza and how this may lead to effective interventions. As this symposium will take place in the aftermath of the first pandemic in 40 years, there will be a wealth of new knowledge as well as intense scientific interest in the subject. In view of the particular interest in influenza and other viral respiratory diseases generated in the Asia-Pacific region arising from the avian flu H5N1 and SARS experience, situating the meeting in Hong Kong would be particularly appropriate.
Scholarship Deadline: January 21 2011
Discounted Abstract Deadline: January 21 2011
Abstract Deadline: February 22 2011
Discounted Registration Deadline: March 22 2011
We gratefully acknowledge additional support for this conference from:
Landes Bioscience
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI094917-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, May 23 | 3:00PM - 7:30PM
Registration
Room: Ballroom A, Foyer


Monday, May 23 | 6:15PM - 7:15PM
Refreshments
Room: Ballroom A, Foyer


Monday, May 23 | 7:15PM - 10:00PM
Keynote Session
Room: Ballroom B,C

Speaker 4 of 4
Peter C. Doherty, University of Melbourne, Australia
T Cells

Monday, May 23 | 7:15PM - 10:00PM
Keynote Session
Room: Ballroom B,C

Speaker 3 of 4
Robert G. Webster, St. Jude Children's Research Hospital, USA
The Ecology of Influenza Viruses

Monday, May 23 | 7:15PM - 10:00PM
Keynote Session
Room: Ballroom B,C

Speaker 2 of 4
Sir John J. Skehel, MRC National Institute of Medical Research, UK
Structure Function of HA

Monday, May 23 | 7:15PM - 10:00PM
Keynote Session
Room: Ballroom B,C

Speaker 1 of 4
* Malik Peiris, University of Hong Kong, Hong Kong
Introduction

Tuesday, May 24 | 8:00AM - 9:00AM
Poster Setup
Room: Ballroom A


Tuesday, May 24 | 8:00AM - 9:00AM
Breakfast
Room: Celestial Court


Tuesday, May 24 | 9:00AM - 12:00PM
Virology
Room: Ballroom B-C

Speaker 6 of 6
Jim-Tong Horng, Chang Gung University, Taiwan
Short Talk: Identification of BPR3P0128 as an Inhibitor against Cap Snatching Activity of Influenza Virus

Tuesday, May 24 | 9:00AM - 12:00PM
Virology
Room: Ballroom B-C

Speaker 5 of 6
Nadia Naffakh, Institut Pasteur, France
Influenza Ribonucleoproteins - Host Cell Interactions

Tuesday, May 24 | 9:00AM - 12:00PM
Virology
Room: Ballroom B-C

Speaker 4 of 6
Yi Guan, University of Hong Kong, Hong Kong
The Emergence of the H1N1/2009 Pandemic Influenza virus

Tuesday, May 24 | 9:00AM - 12:00PM
Virology
Room: Ballroom B-C

Speaker 3 of 6
Yoshihiro Kawaoka, University of Wisconsin / University of Tokyo, USA
Influenza Pathogenesis

Tuesday, May 24 | 9:00AM - 12:00PM
Virology
Room: Ballroom B-C

Speaker 2 of 6
Ron A.M. Fouchier, Erasmus Medical Center Rotterdam, Netherlands
Viral Virulence

Tuesday, May 24 | 9:00AM - 12:00PM
Virology
Room: Ballroom B-C

Speaker 1 of 6
* Andrew S. Pekosz, Johns Hopkins University, USA

Tuesday, May 24 | 10:20AM - 10:40AM
Coffee Break
Room: Ballroom A, Foyer


Tuesday, May 24 | 12:00PM - 2:30PM
Poster Session 1
Room: Ballroom A


Tuesday, May 24 | 12:00PM - 5:00PM
Poster Viewing
Room: Ballroom A


Tuesday, May 24 | 12:00PM - 1:00PM
Lunch
Room: Ballroom A, Tang Rooms


Tuesday, May 24 | 2:00PM - 2:30PM
Coffee Available
Room: Ballroom A, Foyer


Tuesday, May 24 | 2:30PM - 5:00PM
Virus Receptors/Glycans/Structure
Room: Ballroom B-C

Speaker 5 of 6
Patrick C. Reading, University of Melbourne, Australia
Short Talk: Specific Sites of N-linked Glycosylation on the Hemagglutinin of H1N1 Subtype Influenza A Virus Determine Sensitivity to C-Type Lectins of the Innate Immune System

Tuesday, May 24 | 2:30PM - 5:00PM
Virus Receptors/Glycans/Structure
Room: Ballroom B-C

Speaker 4 of 6
Ian A. Wilson, The Scripps Research Institute, USA
New Insights into Broad Neutralization of Influenza Virus and Implications for a Universal Flu Vaccine

Tuesday, May 24 | 2:30PM - 5:00PM
Virus Receptors/Glycans/Structure
Room: Ballroom B-C

Speaker 3 of 6
Ram Sasisekharan, Massachusetts Institute of Technology, USA
Glycans and HA

Tuesday, May 24 | 2:30PM - 5:00PM
Virus Receptors/Glycans/Structure
Room: Ballroom B-C

Speaker 2 of 6
John Nicholls, University of Hong Kong, China
Receptors in the Human Respiratory Tract - Making and Breaking the links

Tuesday, May 24 | 2:30PM - 5:00PM
Virus Receptors/Glycans/Structure
Room: Ballroom B-C

Speaker 1 of 6
* Sir John J. Skehel, MRC National Institute of Medical Research, UK

Tuesday, May 24 | 2:30PM - 5:00PM
Virus Receptors/Glycans/Structure
Room: Ballroom B-C

Speaker 6 of 6
Gillian M. Air, University of Oklahoma Health Sciences Center, USA
Binding and Cleavage of Sialylated Glycans by H3N2 and H1N1 Influenza Viruses

Wednesday, May 25 | 8:00AM - 9:00AM
Breakfast
Room: Celestial Court


Wednesday, May 25 | 9:00AM - 12:00PM
Human Disease, Lung Injury and Human-Cell Experimental Model
s

Room: Ballroom B-C

Speaker 1 of 6
* Yoshihiro Kawaoka, University of Wisconsin / University of Tokyo, USA

Wednesday, May 25 | 9:00AM - 12:00PM
Human Disease, Lung Injury and Human-Cell Experimental Model
s

Room: Ballroom B-C

Speaker 2 of 6
Sherif R. Zaki, Centers for Disease Control and Prevention, USA
Influenza Pathogenesis in Humans: Revisited

Wednesday, May 25 | 9:00AM - 12:00PM
Human Disease, Lung Injury and Human-Cell Experimental Model
s

Room: Ballroom B-C

Speaker 3 of 6
Arthur Slutsky, University of Toronto, Canada
Lung Injury and ARDS

Wednesday, May 25 | 9:00AM - 12:00PM
Human Disease, Lung Injury and Human-Cell Experimental Model
s

Room: Ballroom B-C

Speaker 4 of 6
Paul G. Thomas, St. Jude Children's Research Hospital, USA
Short Talk: Elucidating Early Site-of-Infection Immune Responses to Influenza A in Young Children

Wednesday, May 25 | 9:00AM - 12:00PM
Human Disease, Lung Injury and Human-Cell Experimental Model
s

Room: Ballroom B-C

Speaker 5 of 6
Sagi Shapira, Broad Institute, USA
Host-Influenza Interactions

Wednesday, May 25 | 9:00AM - 12:00PM
Human Disease, Lung Injury and Human-Cell Experimental Model
s

Room: Ballroom B-C

Speaker 6 of 6
Malik Peiris, University of Hong Kong, Hong Kong
Human ex-vivo and in-vitro Experimental Models for Studying Influenza Pathogenesis

Wednesday, May 25 | 10:20AM - 10:40AM
Coffee Break
Room: Ballroom A, Foyer


Wednesday, May 25 | 12:00PM - 1:00PM
Lunch
Room: Ballroom A, Tang Rooms


Wednesday, May 25 | 1:00PM - 2:30PM
Workshop 1: Pathogen-Host Interaction
Room: Ballroom B-C

Speaker 1 of 6
* Nadia Naffakh, Institut Pasteur, France

Wednesday, May 25 | 1:00PM - 2:30PM
Workshop 1: Pathogen-Host Interaction
Room: Ballroom B-C

Speaker 2 of 6
Marciela DeGrace, Harvard University, USA
Dissecting the Role of Trafficking Machinery in the Influenza a Life Cycle Reveals Novel Restriction Factors

Wednesday, May 25 | 1:00PM - 2:30PM
Workshop 1: Pathogen-Host Interaction
Room: Ballroom B-C

Speaker 3 of 6
Gregory A. Boivin, McGill University, Canada
Combining Clinical and Expression QTLs in the Context of Infection: New Insights into Susceptibility to Influenza

Wednesday, May 25 | 1:00PM - 2:30PM
Workshop 1: Pathogen-Host Interaction
Room: Ballroom B-C

Speaker 4 of 6
Michael C.W. Chan, University of Hong Kong, Hong Kong
Impaired Alveolar Edema Fluid Clearance in Human Alveolar Epithelial Cells Injured by Severe Influenza A Virus Infection

Wednesday, May 25 | 1:00PM - 2:30PM
Workshop 1: Pathogen-Host Interaction
Room: Ballroom B-C

Speaker 5 of 6
Rafael A. Medina, Pontificia Universidad Catolica de Chile, Chile
Effects of Glycosylations in the Globular Head of the 2009 H1N1 Influenza Virus Hemagglutinin: Modulation of Virulence and Antigenicity

Wednesday, May 25 | 1:00PM - 2:30PM
Workshop 1: Pathogen-Host Interaction
Room: Ballroom B-C

Speaker 6 of 6
Iris K. Pang, Chinese University of Hong Kong, Hong Kong
Mechanism of IL-1- Dependent Protective Immunity Against Influenza Virus

Wednesday, May 25 | 2:00PM - 2:30PM
Coffee Available
Room: Ballroom A, Foyer


Wednesday, May 25 | 2:30PM - 4:45PM
Experimental Models
Room: Ballroom B-C

Speaker 1 of 4
* Adolfo García-Sastre, Mount Sinai School of Medicine, USA

Wednesday, May 25 | 2:30PM - 4:45PM
Experimental Models
Room: Ballroom B-C

Speaker 2 of 4
Andrew S. Pekosz, Johns Hopkins University, USA
Influenza A Virus Infection of Primary, Differentiated Respiratory Epithelial Cell Cultures

Wednesday, May 25 | 2:30PM - 4:45PM
Experimental Models
Room: Ballroom B-C

Speaker 3 of 4
Jacqueline M. Katz, Centers for Disease Control and Prevention, USA
Small Animal Models for the Study of Influenza Virus Pathogenesis

Wednesday, May 25 | 2:30PM - 4:45PM
Experimental Models
Room: Ballroom B-C

Speaker 4 of 4
Kanta Subbarao, WHO Collaborating Centre for Reference and Research on Influenza, Australia
Replication of Influenza Viruses in Non-Human Primates

Wednesday, May 25 | 4:45PM - 5:00PM
European Research Activities on Influenza
Room: Ballroom B-C

Speaker 1 of 1
Christian Desaintes, European Commission, Belgium
Short Talk: Research Activities Supported by the European Commission on Influenza

Thursday, May 26 | 8:00AM - 9:00AM
Breakfast
Room: Celestial Court


Thursday, May 26 | 8:00AM - 9:00AM
Poster Setup
Room: Ballroom A


Thursday, May 26 | 9:00AM - 12:00PM
Immunity
Room: Ballroom B-C

Speaker 1 of 7
* Jacqueline M. Katz, Centers for Disease Control and Prevention, USA

Thursday, May 26 | 9:00AM - 12:00PM
Immunity
Room: Ballroom B-C

Speaker 2 of 7
Gunther Hartmann, Universitätsklinikum Bonn, Germany
Mechanisms of RNA Recognition through RIG-I and TLR7

Thursday, May 26 | 9:00AM - 12:00PM
Immunity
Room: Ballroom B-C

Speaker 3 of 7
Hui-Ling Yen, University of Hong Kong, Hong Kong
Short Talk: Gene Constellation Determines the Transmissibility of the 2009 Pandemic H1N1 Influenza Viruses in a Ferret Model

Thursday, May 26 | 9:00AM - 12:00PM
Immunity
Room: Ballroom B-C

Speaker 4 of 7
Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
NLRs and Viral Infection

Thursday, May 26 | 9:00AM - 12:00PM
Immunity
Room: Ballroom B-C

Speaker 5 of 7
Seema Lakdawala, University of Pittsburgh School of Medicine, USA
Short Talk: Aerosol Transmission of the Pandemic H1N1 Influenza Virus

Thursday, May 26 | 9:00AM - 12:00PM
Immunity
Room: Ballroom B-C

Speaker 6 of 7
Toshihiro Ito, Okayama University, Japan
Short Talk: The Critical Role of Notch Ligand Delta-like 1 in Influenza A Virus Infection

Thursday, May 26 | 9:00AM - 12:00PM
Immunity
Room: Ballroom B-C

Speaker 7 of 7
Ken J. Ishii, National Institute of Biomedical Innovation, Health and Nutrition, Japan
Endo- and Exogenous Adjuvant for Influenza Vaccination

Thursday, May 26 | 10:20AM - 10:40AM
Coffee Break
Room: Ballroom A, Foyer


Thursday, May 26 | 12:00PM - 1:00PM
Lunch
Room: Ballroom A, Tang Rooms


Thursday, May 26 | 12:00PM - 5:00PM
Poster Viewing
Room: Ballroom A


Thursday, May 26 | 12:00PM - 2:30PM
Poster Session 2
Room: Ballroom A


Thursday, May 26 | 2:00PM - 2:30PM
Coffee Available
Room: Ballroom A, Foyer


Thursday, May 26 | 2:30PM - 5:00PM
Immunity, Systems Biology, Gender and Susceptibility
Room: Ballroom B-C

Speaker 1 of 6
* Peter C. Doherty, University of Melbourne, Australia

Thursday, May 26 | 2:30PM - 5:00PM
Immunity, Systems Biology, Gender and Susceptibility
Room: Ballroom B-C

Speaker 2 of 6
Tao Dong, University of Oxford, UK
Antigen Specific T Cells in Human Influenza A Virus Infection

Thursday, May 26 | 2:30PM - 5:00PM
Immunity, Systems Biology, Gender and Susceptibility
Room: Ballroom B-C

Speaker 3 of 6
Jack R. Bennink, NIAID, National Institutes of Health, USA
Antigenic Drift: Mechanisms of Influenza A Virus Hemagglutinin Immune Escape

Thursday, May 26 | 2:30PM - 5:00PM
Immunity, Systems Biology, Gender and Susceptibility
Room: Ballroom B-C

Speaker 4 of 6
Thomas C. Friedrich, University of Wisconsin, USA
Short Talk: Cross-Reactive T Cells are Involved in Rapid Clearance of 2009 Pandemic H1N1 Influenza Virus Infection by Nonhuman Primates

Thursday, May 26 | 2:30PM - 5:00PM
Immunity, Systems Biology, Gender and Susceptibility
Room: Ballroom B-C

Speaker 5 of 6
Ronald N. Germain, NIAID, National Institutes of Health, USA
A Systems Approach to Influenza Infection and Vaccine Responses

Thursday, May 26 | 2:30PM - 5:00PM
Immunity, Systems Biology, Gender and Susceptibility
Room: Ballroom B-C

Speaker 6 of 6
Sabra L. Klein, Johns Hopkins University, USA
Sex Differences in Response to Influenza Virus Infection and Vaccination

Friday, May 27 | 8:00AM - 9:00AM
Breakfast
Room: Celestial Court


Friday, May 27 | 9:00AM - 12:00PM
Pathogenesis and Transmission
Room: Ballroom B-C

Speaker 1 of 6
* Ron A.M. Fouchier, Erasmus Medical Center Rotterdam, Netherlands

Friday, May 27 | 9:00AM - 12:00PM
Pathogenesis and Transmission
Room: Ballroom B-C

Speaker 2 of 6
Adolfo García-Sastre, Mount Sinai School of Medicine, USA
In vivo Dynamics of Influenza Virus Infection

Friday, May 27 | 9:00AM - 12:00PM
Pathogenesis and Transmission
Room: Ballroom B-C

Speaker 3 of 6
Connie Y.H. Leung, University of Hong Kong, Hong Kong
Short Talk: Toll-like Receptor (TLR)3 Signaling Contributes to Enhanced Disease Severity in H5N1 but not Pandemic H1N1 Infection in Mice

Friday, May 27 | 9:00AM - 12:00PM
Pathogenesis and Transmission
Room: Ballroom B-C

Speaker 4 of 6
Christopher J. O'Donnell, NHLBI, National Institutes of Health, USA
Short Talk: Antibody Pressure by a Human Monoclonal Antibody (hMAb) Targeting the Sa Region of 2009 Pandemic H1N1 Virus Hemagglutinin can Drive the Development of a More Virulent Virus

Friday, May 27 | 9:00AM - 12:00PM
Pathogenesis and Transmission
Room: Ballroom B-C

Speaker 5 of 6
Alexandra Godlee, Imperial College London, UK
Influenza-Induced Immunological Alterations in the Respiratory Tract

Friday, May 27 | 9:00AM - 12:00PM
Pathogenesis and Transmission
Room: Ballroom B-C

Speaker 6 of 6
Daniel R. Perez, University of Maryland, USA
Challenges in Understanding Influenza Transmission

Friday, May 27 | 10:20AM - 10:40AM
Coffee Break
Room: Ballroom A, Foyer


Friday, May 27 | 12:00PM - 1:00PM
Lunch
Room: Ballroom A, Tang Rooms


Friday, May 27 | 1:00PM - 2:30PM
Workshop 2: Modulation of Infection
Room: Ballroom B-C

Speaker 1 of 6
* Paul G. Thomas, St. Jude Children's Research Hospital, USA

Friday, May 27 | 1:00PM - 2:30PM
Workshop 2: Modulation of Infection
Room: Ballroom B-C

Speaker 2 of 6
Kobporn Boonnak, Mahidol University, Thailand
Treatment of Influenza Virus Infection with Viral Peptides Linked to Dendritic Cells

Friday, May 27 | 1:00PM - 2:30PM
Workshop 2: Modulation of Infection
Room: Ballroom B-C

Speaker 3 of 6
Huailiang Ma, Emory University, USA
Human Annexin A6 Interacts with the Influenza A Virus M2 Protein and Negatively Modulates Infection

Friday, May 27 | 1:00PM - 2:30PM
Workshop 2: Modulation of Infection
Room: Ballroom B-C

Speaker 4 of 6
Wenwei Tu, University of Hong Kong, China
Pamidronate Boosts gammadelta-T-Cell Immunity and Controls Influenza A Infection: A Novel Therapeutic Option for Influenza

Friday, May 27 | 1:00PM - 2:30PM
Workshop 2: Modulation of Infection
Room: Ballroom B-C

Speaker 5 of 6
Susanne Herold, University of Giessen Lung Center, Germany
Alveolar Epithelial Cells Shape Pulmonary Dendritic Cell Antiviral Responses in Severe Influenza Virus Pneumonia by Expression of GM-CSF

Friday, May 27 | 1:00PM - 2:30PM
Workshop 2: Modulation of Infection
Room: Ballroom B-C

Speaker 6 of 6
Michael Schotsaert, Icahn School of Medicine at Mount Sinai, USA
M2e-Based Universal Vaccine Protects against Influenza A Virus Challenge and Enhances Heterosubtypic Immunity during Subsequent Infections

Friday, May 27 | 2:00PM - 2:30PM
Coffee Available
Room: Ballroom A, Foyer


Friday, May 27 | 2:30PM - 5:00PM
Interventions
Room: Ballroom B-C

Speaker 1 of 5
* Kanta Subbarao, WHO Collaborating Centre for Reference and Research on Influenza, Australia

Friday, May 27 | 2:30PM - 5:00PM
Interventions
Room: Ballroom B-C

Speaker 2 of 5
Philip Dormitzer, Pfizer Vaccine Research and Development, USA
Advances in Vaccines Against Seasonal and Pandemic Influenza

Friday, May 27 | 2:30PM - 5:00PM
Interventions
Room: Ballroom B-C

Speaker 3 of 5
YanChun Peng, University of Oxford, UK
Short Talk: Influenza Specific T Cell Responses after Influenza Virus Challenge in Individuals Vaccinated with NP and M1 Containing MVA Vaccine

Friday, May 27 | 2:30PM - 5:00PM
Interventions
Room: Ballroom B-C

Speaker 4 of 5
Chi-Huey Wong, Academia Sinica, Taiwan
Toward the Design of Universal Glycoprotein Vaccines against
Influenza and other Viral Diseases


Friday, May 27 | 2:30PM - 5:00PM
Interventions
Room: Ballroom B-C

Speaker 5 of 5
Stephan Ludwig, University of Münster, Germany
Intracellular Signal Transduction and Influenza Virus Infection – Identifying Novel Targets for Antiviral Therapy

Friday, May 27 | 5:30PM - 5:35PM
Depart hotel lobby and transfer to cruise


Friday, May 27 | 8:00PM - 9:15PM
Dragon Pearl Cruise with dinner


Friday, May 27 | 9:00PM - 9:15PM
Disembark Dragon Pearl Cruise and transfer back to hotel


Saturday, May 28 | 10:25AM - 10:25AM
Departure


*Session Chair.