Web Desc
The Evolution of Protein Phosphorylation
Organizer(s): Tony Hunter and Tony Pawson
Date: January 23 - 28, 2011
Location: Keystone Resort, Keystone, CO, USA
Supported by the Directors' Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Major progress has been made in defining the basis of signaling in eukaryotic cells both with respect to the function and structure of protein modules that are involved in signaling and how these proteins are organized into pathways and networks that are used to regulate cellular responses to extracellular and intracellular stimuli. Through intensive studies over the past 40 years protein phosphorylation has become one of the best understood signaling mechanisms. Most of what has been learned has been derived from studies of a few model organisms, which have taught us that several major signal transduction pathways are conserved in evolution. The recent flood of new eukaryotic genome sequences has engendered significant interest in understanding the evolution of the protein kinases and phosphatases and other signaling proteins involved in protein phosphorylation (e.g. where did tyrosine kinases come from?). In addition, the explosion of phosphoproteomic data from multiple organisms (including prokaryotes) indicates that the majority of proteins in the cell may be phosphorylated, leading to questions such as whether all the detected phosphorylation events are functional, and how this can be addressed, especially for highly phosphorylated proteins. Our increasingly systems-based understanding of the genes involved in phosphorylation signaling and the identification of the full spectrum of proteins that are reversibly phosphorylated now makes it possible to ask to what extent phosphorylation of specific sites or regions is conserved during evolution, which may provide important functional insights. In addition to these topics, the meeting will cover the evolution of protein kinases and phosphatases and key signaling modules, such as the SH2 and SH3 domains, and the evolution of protein phosphorylation in prokaryotes and plants and how their systems differ from those in animals. A number of other topics, such as the functional conservation of orthologous proteins involved in phosphorylation, whether phosphorylation network architecture has been conserved, and the evolutionary function of conserved pseudokinases, will be discussed. Clearly for this topic it is particularly important to have as broad a representation as possible from the different areas of protein phosphorylation, we have selected speakers working on a wide range of eukaryotic and prokaryotic organisms in order to emphasize the evolution and conservation of protein phosphorylation.
Scholarship Deadline: September 27 2010
Discounted Abstract Deadline: September 27 2010
Abstract Deadline: October 28 2010
Discounted Registration Deadline: November 29 2010
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Sunday, January 23 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Sunday, January 23 | 6:30PM - 7:30PM
Refreshments
Room: Longs Peak Foyer


Sunday, January 23 | 7:30PM - 8:30PM
Welcome and Keynote Address
Room: Grays Peak

Speaker 1 of 2
Tony Hunter, The Salk Institute for Biological Sciences, USA
Why did Nature Choose Phosphate and Use it to Modify Proteins?

Sunday, January 23 | 7:30PM - 8:30PM
Welcome and Keynote Address
Room: Grays Peak

Speaker 2 of 2
Tony Pawson, Samuel Lunenfeld Research Institute, Canada
Evolution of Phosphotyrosine and Methylarginine Signaling

Monday, January 24 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Monday, January 24 | 8:00AM - 11:15AM
Bioinformatics of Protein Phosphorylation
Room: Grays Peak

Speaker 1 of 7
* Tony Hunter, The Salk Institute for Biological Sciences, USA

Monday, January 24 | 8:00AM - 11:15AM
Bioinformatics of Protein Phosphorylation
Room: Grays Peak

Speaker 2 of 7
Gerard Manning, Genentech, Inc., USA
Kinome Evolution

Monday, January 24 | 8:00AM - 11:15AM
Bioinformatics of Protein Phosphorylation
Room: Grays Peak

Speaker 3 of 7
Rune Linding, University of Copenhagen, Denmark
Evolution of Complex Regulatory Systems - Signaling Fidelity and Disease


Monday, January 24 | 8:00AM - 11:15AM
Bioinformatics of Protein Phosphorylation
Room: Grays Peak

Speaker 4 of 7
Alex N. Nguyen Ba, University of Toronto, Canada
Short Talk: Evolution of Characterized Phosphorylation Sites in Budding Yeast

Monday, January 24 | 8:00AM - 11:15AM
Bioinformatics of Protein Phosphorylation
Room: Grays Peak

Speaker 5 of 7
James E. Ferrell Jr., Stanford University, USA
A Mechanism for the Evolution of Phosohrylation Sites

Monday, January 24 | 8:00AM - 11:15AM
Bioinformatics of Protein Phosphorylation
Room: Grays Peak

Speaker 6 of 7
Matthew P. Jacobson, University of California, San Francisco, USA
Short Talk: Computational Studies of Protein Regulation by Post-Translational Phosphorylation

Monday, January 24 | 8:00AM - 11:15AM
Bioinformatics of Protein Phosphorylation
Room: Grays Peak

Speaker 7 of 7
Nicholas K. Tonks, Cold Spring Harbor Laboratory, USA
Signal Transduction from a Protein Tyrosine Phosphatase Perspective

Monday, January 24 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, January 24 | 11:15AM - 1:00PM
Poster Setup
Room: Longs Peak


Monday, January 24 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, January 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Monday, January 24 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, January 24 | 5:00PM - 7:15PM
Phosphoproteomics
Room: Grays Peak

Speaker 1 of 6
* Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute, Canada

Monday, January 24 | 5:00PM - 7:15PM
Phosphoproteomics
Room: Grays Peak

Speaker 2 of 6
Steven P. Gygi, Harvard Medical School, USA
A Comprehensive Strategy to Study Phosphorylation Dynamics Shows Partial Redundancy between MAPK Pathways in Yeast

Monday, January 24 | 5:00PM - 7:15PM
Phosphoproteomics
Room: Grays Peak

Speaker 3 of 6
Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zürich, Switzerland
Kinase-Substrate Networks

Monday, January 24 | 5:00PM - 7:15PM
Phosphoproteomics
Room: Grays Peak

Speaker 4 of 6
Judit Villen, University of Washington, USA
Short Talk: Evolution of Phosphoregulation in the Cell Cycle

Monday, January 24 | 5:00PM - 7:15PM
Phosphoproteomics
Room: Grays Peak

Speaker 5 of 6
Anton Iliuk, Tymora Analytical, USA
Short Talk: Developing Novel Technologies for Phosphoproteomic Analyses

Monday, January 24 | 5:00PM - 7:15PM
Phosphoproteomics
Room: Grays Peak

Speaker 6 of 6
Philip A. Cole, Johns Hopkins University School of Medicine, USA
Chemical Approaches to Sorting out Protein Signaling Pathways

Monday, January 24 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Longs Peak


Monday, January 24 | 7:30PM - 10:00PM
Poster Session 1
Room: Longs Peak


Tuesday, January 25 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Tuesday, January 25 | 8:00AM - 11:15AM
Phosphorylation Networks
Room: Grays Peak

Speaker 1 of 7
* Wendell A. Lim, University of California, San Francisco, USA

Tuesday, January 25 | 8:00AM - 11:15AM
Phosphorylation Networks
Room: Grays Peak

Speaker 2 of 7
Nevan J. Krogan, University of California, San Francisco, USA
Evolutionary Dynamics of Phosphorylation

Tuesday, January 25 | 8:00AM - 11:15AM
Phosphorylation Networks
Room: Grays Peak

Speaker 3 of 7
Stephen W. Michnick, Université de Montréal, Canada
Causality and Contingency in Protein Interaction (Signaling) Networks

Tuesday, January 25 | 8:00AM - 11:15AM
Phosphorylation Networks
Room: Grays Peak

Speaker 4 of 7
Michael Tyers, Canada
Kinase/Phosphatase Interaction Networks

Tuesday, January 25 | 8:00AM - 11:15AM
Phosphorylation Networks
Room: Grays Peak

Speaker 5 of 7
Brenda J. Andrews, University of Toronto, Canada
Short Talk: Phosphorylation Networks: A Comprehensive Genetic Interaction Map of a Eukaryotic Kinase

Tuesday, January 25 | 8:00AM - 11:15AM
Phosphorylation Networks
Room: Grays Peak

Speaker 6 of 7
Luca Freschi, Institut de Biologie Intégrative et des Systèmes, Canada
Short Talk: Regulatory Network Rewiring by Gene Duplication

Tuesday, January 25 | 8:00AM - 11:15AM
Phosphorylation Networks
Room: Grays Peak

Speaker 7 of 7
Michael B. Yaffe, Massachusetts Institute of Technology, USA
Integration of Mitotic Kinases, MAP Kinases and DNA Damage Signaling Networks

Tuesday, January 25 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, January 25 | 11:15AM - 1:00PM
Poster Setup
Room: Longs Peak


Tuesday, January 25 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, January 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Tuesday, January 25 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, January 25 | 5:00PM - 7:00PM
Evolution of Tyrosine Phosphorylation
Room: Grays Peak

Speaker 1 of 6
* Tony Hunter, The Salk Institute for Biological Sciences, USA

Tuesday, January 25 | 5:00PM - 7:00PM
Evolution of Tyrosine Phosphorylation
Room: Grays Peak

Speaker 2 of 6
Wendell A. Lim, University of California, San Francisco, USA
Evolution of the Phosphor-Tyrosine Signaling Toolkit

Tuesday, January 25 | 5:00PM - 7:00PM
Evolution of Tyrosine Phosphorylation
Room: Grays Peak

Speaker 3 of 6
Piers Nash, University of Chicago, USA
Short Talk: SH2 Domain Linguistics and the Evolution of Selective Interactions

Tuesday, January 25 | 5:00PM - 7:00PM
Evolution of Tyrosine Phosphorylation
Room: Grays Peak

Speaker 4 of 6
Shohei Koide, New York University Langone Health, USA
Short Talk: Dissecting and Controlling SH2-Mediated Regulation with Designer Binding Proteins

Tuesday, January 25 | 5:00PM - 7:00PM
Evolution of Tyrosine Phosphorylation
Room: Grays Peak

Speaker 5 of 6
Bruce J. Mayer, University of Connecticut Health Center, USA
Profiling Global Tyrosine Phosphorylation Patterns: Implications for the Evolution and Design of Tyrosine Kinase Signaling Networks

Tuesday, January 25 | 5:00PM - 7:00PM
Evolution of Tyrosine Phosphorylation
Room: Grays Peak

Speaker 6 of 6
Joel P. Wagner, Massachusetts Institute of Technology, USA
Short Talk: Confronting Complexity: Analysis of Six Evolutionary Diverse RTK Networks

Tuesday, January 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs Peak


Tuesday, January 25 | 7:30PM - 10:00PM
Poster Session 2
Room: Longs Peak


Wednesday, January 26 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Wednesday, January 26 | 8:00AM - 11:00AM
Evolution of Prokaryotic Protein Kinases
Room: Grays Peak

Speaker 1 of 7
* Susan S. Taylor, University of California, San Diego, USA

Wednesday, January 26 | 8:00AM - 11:00AM
Evolution of Prokaryotic Protein Kinases
Room: Grays Peak

Speaker 2 of 7
Tom Alber, University of California, Berkeley, USA
Ser/Thr Phosphosignaling in Tuberculosis

Wednesday, January 26 | 8:00AM - 11:00AM
Evolution of Prokaryotic Protein Kinases
Room: Grays Peak

Speaker 3 of 7
Christophe Grangeasse, CNRS - University of Lyon, France
Short Talk: Bacterial Tyrosine-Kinases

Wednesday, January 26 | 8:00AM - 11:00AM
Evolution of Prokaryotic Protein Kinases
Room: Grays Peak

Speaker 4 of 7
Sylvie Nessler, Laboratoire d'Enzymologie et Biochimie Structurales, France
Short Talk: Structure Function Analysis of Bacterial P-Loop Protein Kinases Characterized by a Walker A Motif BY Kinase and HPrK/P

Wednesday, January 26 | 8:00AM - 11:00AM
Evolution of Prokaryotic Protein Kinases
Room: Grays Peak

Speaker 5 of 7
Ann M. Stock, University of Medicine and Dentistry of New Jersey, USA
Mechanistic Diversity in Bacterial Two-Component Signaling Systems

Wednesday, January 26 | 8:00AM - 11:00AM
Evolution of Prokaryotic Protein Kinases
Room: Grays Peak

Speaker 6 of 7
Michael T. Laub, Massachusetts Institute of Technology, USA
Specificity and Evolution of Two-Component Signaling Pathways

Wednesday, January 26 | 8:00AM - 11:00AM
Evolution of Prokaryotic Protein Kinases
Room: Grays Peak

Speaker 7 of 7
Andrew Xiao, Yale University, USA
Short Talk: The Function of WSTF in DNA Damage Response and Development

Wednesday, January 26 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, January 26 | 11:00AM - 1:00PM
Poster Setup
Room: Longs Peak


Wednesday, January 26 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Wednesday, January 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs Peak


Wednesday, January 26 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, January 26 | 5:00PM - 7:15PM
Protein Kinase Medley
Room: Grays Peak

Speaker 1 of 6
* Bruce J. Mayer, University of Connecticut Health Center, USA

Wednesday, January 26 | 5:00PM - 7:15PM
Protein Kinase Medley
Room: Grays Peak

Speaker 2 of 6
Shin-Han Shiu, Michigan State University, USA
Why Does this Thing has >1000 Receptor-like Kinases?

Wednesday, January 26 | 5:00PM - 7:15PM
Protein Kinase Medley
Room: Grays Peak

Speaker 3 of 6
Christian Doerig, Monash University, Australia
The Plasmodium Kinome: An Untapped Source of Potential Targets for Antimalarial Drug Discovery

Wednesday, January 26 | 5:00PM - 7:15PM
Protein Kinase Medley
Room: Grays Peak

Speaker 4 of 6
Edward Y. Skolnik, New York University Medical Center, USA
Short Talk: Regulation of the Potassium Channel KCa3.1

Wednesday, January 26 | 5:00PM - 7:15PM
Protein Kinase Medley
Room: Grays Peak

Speaker 5 of 6
Nicole LaRonde-LeBlanc, University of Maryland, USA
Short Talk: The RIO Kinases: An Ancient Protein Kinase Family with Influence in Cellular Proliferation and Motility

Wednesday, January 26 | 5:00PM - 7:15PM
Protein Kinase Medley
Room: Grays Peak

Speaker 6 of 6
Natalie G. Ahn, University of Colorado, USA
A New Role to Cell Polarity by Wnt5a Signaling

Wednesday, January 26 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Longs Peak


Wednesday, January 26 | 7:30PM - 10:00PM
Poster Session 3
Room: Longs Peak


Thursday, January 27 | 7:00AM - 8:00AM
Breakfast
Room: Longs Peak


Thursday, January 27 | 8:00AM - 11:15AM
Evolution of Protein Structures Used in Phosphorylation
Room: Grays Peak

Speaker 1 of 8
* Ann M. Stock, University of Medicine and Dentistry of New Jersey, USA

Thursday, January 27 | 8:00AM - 11:15AM
Evolution of Protein Structures Used in Phosphorylation
Room: Grays Peak

Speaker 2 of 8
Susan S. Taylor, University of California, San Diego, USA
PKA: Evolution of a Dynamic Allosteric Macromolecular Signaling Complex

Thursday, January 27 | 8:00AM - 11:15AM
Evolution of Protein Structures Used in Phosphorylation
Room: Grays Peak

Speaker 3 of 8
Louise N. Johnson, University of Oxford, UK
The Structural Basis for Control by Phosphorylation and Protein Kinase Inhibitors

Thursday, January 27 | 8:00AM - 11:15AM
Evolution of Protein Structures Used in Phosphorylation
Room: Grays Peak

Speaker 4 of 8
Natarajan Kannan, University of Georgia, USA
Short Talk: Delineating Protein Kinase Design Principles using Sequence Data

Thursday, January 27 | 8:00AM - 11:15AM
Evolution of Protein Structures Used in Phosphorylation
Room: Grays Peak

Speaker 5 of 8
Zongchao Jia, Queen's University, Canada
Short Talk: Structures of E. coli Bifunctional Isocitrate Dehydrogenase Kinase/ Phosphatase and its Complex with Isocitrate Dehydrogenase

Thursday, January 27 | 8:00AM - 11:15AM
Evolution of Protein Structures Used in Phosphorylation
Room: Grays Peak

Speaker 6 of 8
Andrei V. Karginov, University of Illinois at Chicago, USA
Short Talk: Engineered Allosteric Regulation of Kinases in Living Cells

Thursday, January 27 | 8:00AM - 11:15AM
Evolution of Protein Structures Used in Phosphorylation
Room: Grays Peak

Speaker 7 of 8
Fernando Correa, University of Texas Southwestern Medical Center, USA
Short Talk: Light-Dependent Two-Component Signaling Systems: Enzymatic and Functional Characterization of a LOV-Histidine Kinase

Thursday, January 27 | 8:00AM - 11:15AM
Evolution of Protein Structures Used in Phosphorylation
Room: Grays Peak

Speaker 8 of 8
Stefan Knapp, University of Oxford, UK
Lessons Learned from Wide-Scale Protein Kinase Structure Determination

Thursday, January 27 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, January 27 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Thursday, January 27 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, January 27 | 5:00PM - 7:15PM
Phosphatase Evolution
Room: Grays Peak

Speaker 1 of 6
* Tony Hunter, The Salk Institute for Biological Sciences, USA

Thursday, January 27 | 5:00PM - 7:15PM
Phosphatase Evolution
Room: Grays Peak

Speaker 2 of 6
Tricia Cohen, University of Dundee, UK
Structural and Functional Evolution of Protein Phosphatases in PPP Family

Thursday, January 27 | 5:00PM - 7:15PM
Phosphatase Evolution
Room: Grays Peak

Speaker 3 of 6
Daniel L. Fisher, Institute of Molecular Genetics of Montpellier, France
Short Talk: PP2A Sharpens the Cell Cycle Oscillator

Thursday, January 27 | 5:00PM - 7:15PM
Phosphatase Evolution
Room: Grays Peak

Speaker 4 of 6
Carolyn A. Worby, University of California, San Diego, USA
Highly Conserved Phosphatases: Studies on Laforin and PTPMT1

Thursday, January 27 | 5:00PM - 7:15PM
Phosphatase Evolution
Room: Grays Peak

Speaker 5 of 6
Mark Chen, Genentech, USA
Short Talk: Evolution of Protein Phosphatases from Yeast to Human

Thursday, January 27 | 5:00PM - 7:15PM
Phosphatase Evolution
Room: Grays Peak

Speaker 6 of 6
Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute, Canada
Networking Kinases and Phosphatases: A High Density Interaction Network Reveals a Link between PP2A, Ste20 Kinases and Angioma

Thursday, January 27 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Longs Peak


Thursday, January 27 | 8:00PM - 11:00PM
Entertainment
Room: Longs Peak


Thursday, January 27 | 8:00PM - 11:00PM
Cash Bar
Room: Longs Peak


Friday, January 28 | 10:22AM - 10:22AM
Departure


*Session Chair
†Invited, not yet responded.