Web Desc
Neurodegenerative Diseases: The Molecular and Cellular Basis for Neurodegeneration
Organizer(s): Ted M. Dawson, Virginia M.-Y. Lee and Stephen M. Strittmatter
Date: February 21 - 26, 2011
Location: Sagebrush Inn & Suites, Taos, NM, USA
Sponsored by AstraZeneca Pharmaceuticals, L.P., Genentech, Inc. and Isis Pharmaceuticals, Inc.
Summary of Meeting:
Neurodegenerative diseases are chronic age-dependent progressive disorders that are substantial and growing health problems, which exert a tremendous toll on the patient, family, health system and society as a whole. Accordingly, there is an urgent need to identify therapies that slow and/or reverse the progression of these disorders. Research in neurodegenerative disorders is providing tremendous advances in the molecular understanding of these disorders. New insights in cell biology, biochemistry, genomics and proteomics into these illnesses are leading to mechanism based therapies and new tools and biomarkers to study disease progression and therapeutic efficacy. In this meeting an emphasis will be placed on understanding new molecular and common mechanisms of disease in Alzheimer’s disease (AD), Parkinson’s disease (PD), triple repeat diseases, frontotemporal lobar dementia and others.
Scholarship Deadline: October 20 2010
Discounted Abstract Deadline: October 20 2010
Abstract Deadline: November 22 2010
Discounted Registration Deadline: December 21 2010
We gratefully acknowledge additional support for this conference from:
AlzheimerAstraZeneca Pharmaceuticals, L.P.
Genentech, Inc.
iPierian, Inc.Isis Pharmaceuticals, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

AstraZeneca R&D

Genentech, Inc.


Albert Chiang
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Neural Cell News
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 3R13NS073140-01S1
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, February 21 | 3:00PM - 7:30PM
Registration
Room: Chamisa Lobby


Monday, February 21 | 6:15PM - 7:15PM
Refreshments
Room: Chamisa Ballroom 2


Monday, February 21 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Chamisa Ballroom 1

Speaker 1 of 1
Thomas C. Südhof, Stanford School of Medicine, USA
Neurotransmitter Release and Neurodegeneration: The SNARE Connection

Tuesday, February 22 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Tuesday, February 22 | 8:00AM - 11:15AM
Cognitive and Emotional Deficits in Neurodegenerative Disord
ers: From Molecules to Phenotypes

Room: Chamisa Ballroom 1

Speaker 1 of 7
* Holly Soares, Bristol-Myers Squibb, USA

Tuesday, February 22 | 8:00AM - 11:15AM
Cognitive and Emotional Deficits in Neurodegenerative Disord
ers: From Molecules to Phenotypes

Room: Chamisa Ballroom 1

Speaker 2 of 7
Akira Sawa, Johns Hopkins University, USA
Molecular Link of Huntingtin-PDE4-DISC1: Potential Impact on Emotional and Cognitive Deficits in Huntington’s Disease

Tuesday, February 22 | 8:00AM - 11:15AM
Cognitive and Emotional Deficits in Neurodegenerative Disord
ers: From Molecules to Phenotypes

Room: Chamisa Ballroom 1

Speaker 3 of 7
Dezhi Liao, University of Minnesota, USA
Tau Mislocalization in Neurodegenerative Diseases

Tuesday, February 22 | 8:00AM - 11:15AM
Cognitive and Emotional Deficits in Neurodegenerative Disord
ers: From Molecules to Phenotypes

Room: Chamisa Ballroom 1

Speaker 4 of 7
Tracy L. Young-Pearse, Brigham and Women's Hospital and Harvard Medical School, USA
Bidirectional Signal Crosstalk between APP and DISC1 in Neurodevelopment and Aging

Tuesday, February 22 | 8:00AM - 11:15AM
Cognitive and Emotional Deficits in Neurodegenerative Disord
ers: From Molecules to Phenotypes

Room: Chamisa Ballroom 1

Speaker 5 of 7
Li-Huei Tsai, Massachusetts Institute of Technology, USA
Epigenetics in Cognitive Performance and Alzheimer’s Disease

Tuesday, February 22 | 8:00AM - 11:15AM
Cognitive and Emotional Deficits in Neurodegenerative Disord
ers: From Molecules to Phenotypes

Room: Chamisa Ballroom 1

Speaker 6 of 7
Sreeganga S. Chandra, Yale University, USA
Short Talk: alphabetagamma-Synuclein Triple Knockout Mice Reveal Age-Dependent Neuronal Dysfunction

Tuesday, February 22 | 8:00AM - 11:15AM
Cognitive and Emotional Deficits in Neurodegenerative Disord
ers: From Molecules to Phenotypes

Room: Chamisa Ballroom 1

Speaker 7 of 7
Amantha Thathiah, Catholic University of Leuven, Belgium
Short Talk: GPR3 Modulation the gamma-secretase Complex and Abeta Generation in Alzheimer's Disease

Tuesday, February 22 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Tuesday, February 22 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Tuesday, February 22 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, February 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Tuesday, February 22 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Tuesday, February 22 | 5:00PM - 7:15PM
Monitoring Neurodegenerative Disease Progression
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Lennart Mucke, Gladstone Institutes and University of California, San Francisco, USA

Tuesday, February 22 | 5:00PM - 7:15PM
Monitoring Neurodegenerative Disease Progression
Room: Chamisa Ballroom 1

Speaker 2 of 6
David M. Holtzman, Washington University, USA
CSF Biomarkers: Correlations with Imaging and Value in Diagnosis and Prognosis

Tuesday, February 22 | 5:00PM - 7:15PM
Monitoring Neurodegenerative Disease Progression
Room: Chamisa Ballroom 1

Speaker 3 of 6
John Q. Trojanowski, University of Pennsylvania, USA
Progress in Alzheimer's Disease (AD) Biomarkers from the AD Neuroimaging Initiative (ADNI)

Tuesday, February 22 | 5:00PM - 7:15PM
Monitoring Neurodegenerative Disease Progression
Room: Chamisa Ballroom 1

Speaker 4 of 6
Holly Soares, Bristol-Myers Squibb, USA
Utility of Multiplexed Panels as Screening Tools for Early Detection of Neurodegeneration

Tuesday, February 22 | 5:00PM - 7:15PM
Monitoring Neurodegenerative Disease Progression
Room: Chamisa Ballroom 1

Speaker 5 of 6
Erik S. Musiek, Washington University, USA
Short Talk: Direct Comparison of ASL-MRI and FDG-PET in the Diagnosis of Alzheimer’s Disease

Tuesday, February 22 | 5:00PM - 7:15PM
Monitoring Neurodegenerative Disease Progression
Room: Chamisa Ballroom 1

Speaker 6 of 6
Joel C. Watts, University of California San Francisco, USA
Short Talk: Bioluminescence Imaging of Abeta Deposition in Transgenic Mouse Models of Alzheimer’s Disease

Tuesday, February 22 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Tuesday, February 22 | 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa Ballroom 2


Wednesday, February 23 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Wednesday, February 23 | 8:00AM - 11:15AM
Anatomical and Functional Basis of Dementia and Neurodegener
ation

Room: Chamisa Ballroom 1

Speaker 1 of 7
* Li-Huei Tsai, Massachusetts Institute of Technology, USA

Wednesday, February 23 | 8:00AM - 11:15AM
Anatomical and Functional Basis of Dementia and Neurodegener
ation

Room: Chamisa Ballroom 1

Speaker 2 of 7
Lennart Mucke, Gladstone Institutes and University of California, San Francisco, USA
Key Roles of Tyrosine Kinases and Tau in Abeta-Induced Neuronal Dysfunction

Wednesday, February 23 | 8:00AM - 11:15AM
Anatomical and Functional Basis of Dementia and Neurodegener
ation

Room: Chamisa Ballroom 1

Speaker 3 of 7
Brian J. Bacskai, Massachusetts General Hospital, USA
Imaging Structural and Functional Alterations in AD Models

Wednesday, February 23 | 8:00AM - 11:15AM
Anatomical and Functional Basis of Dementia and Neurodegener
ation

Room: Chamisa Ballroom 1

Speaker 4 of 7
Lynn A. Raymond, University of British Columbia, Canada
The Role of Excitotoxicity in Neurodegeneration in Huntington Disease

Wednesday, February 23 | 8:00AM - 11:15AM
Anatomical and Functional Basis of Dementia and Neurodegener
ation

Room: Chamisa Ballroom 1

Speaker 5 of 7
Dalton James Surmeier, Northwestern University, USA
Phenotypic Determinants of Neuronal Vulnerability in Parkinson's Disease

Wednesday, February 23 | 8:00AM - 11:15AM
Anatomical and Functional Basis of Dementia and Neurodegener
ation

Room: Chamisa Ballroom 1

Speaker 6 of 7
Joshua M. Shulman, Baylor College of Medicine, USA
Short Talk: Enhancing Power for Gene Discovery in Alzheimer’s Disease: Intermediate Phenotypes and Functional Validation in Drosophila

Wednesday, February 23 | 8:00AM - 11:15AM
Anatomical and Functional Basis of Dementia and Neurodegener
ation

Room: Chamisa Ballroom 1

Speaker 7 of 7
Todd J. Cohen, University of Pennsylvania, USA
Short Talk: Tau Acetylation Inhibits Function and Promotes Tau Pathology in Alzheimer’s Disease

Wednesday, February 23 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Wednesday, February 23 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Wednesday, February 23 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Wednesday, February 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Wednesday, February 23 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Wednesday, February 23 | 5:00PM - 7:15PM
Mitochondria and Protein Quality Control Dysfunction in Neur
odegeneration

Room: Chamisa Ballroom 1

Speaker 1 of 6
* Ted M. Dawson, Johns Hopkins University School of Medicine, USA

Wednesday, February 23 | 5:00PM - 7:15PM
Mitochondria and Protein Quality Control Dysfunction in Neur
odegeneration

Room: Chamisa Ballroom 1

Speaker 2 of 6
Ming Guo, University of California, Los Angeles, USA
Mitochondrial Fission and Fusion in Parkinson's Disease

Wednesday, February 23 | 5:00PM - 7:15PM
Mitochondria and Protein Quality Control Dysfunction in Neur
odegeneration

Room: Chamisa Ballroom 1

Speaker 3 of 6
Richard J. Youle, NINDS, National Institutes of Health, USA
Damage Control - How the Pink1/Parkin Pathway can Regulate Removal of Impaired Mitochondria by Autophagy

Wednesday, February 23 | 5:00PM - 7:15PM
Mitochondria and Protein Quality Control Dysfunction in Neur
odegeneration

Room: Chamisa Ballroom 1

Speaker 4 of 6
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Selective Autophagy in Neurodegeneration

Wednesday, February 23 | 5:00PM - 7:15PM
Mitochondria and Protein Quality Control Dysfunction in Neur
odegeneration

Room: Chamisa Ballroom 1

Speaker 5 of 6
Jin-Mi Heo, Harvard Medical School, USA
Short Talk: Identification of Vms1 as a Novel Mitochondrial Stress Responsive Protein Involved in Mitochondrial Protein Quality Control

Wednesday, February 23 | 5:00PM - 7:15PM
Mitochondria and Protein Quality Control Dysfunction in Neur
odegeneration

Room: Chamisa Ballroom 1

Speaker 6 of 6
Thomas M. Durcan, Montreal Neurological Institute, Canada
Short Talk: The Machado-Joseph Disease Associated Mutant Form of Ataxin-3 Promotes Clearance of Parkin Through the Autophagy Pathway

Wednesday, February 23 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Wednesday, February 23 | 7:30PM - 10:00PM
Poster Session 2
Room: Chamisa Ballroom 2


Thursday, February 24 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Thursday, February 24 | 8:00AM - 11:15AM
Neurodegeneration Due to RNA and DNA Regulatory Proteins
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Stephen M. Strittmatter, Yale University, USA

Thursday, February 24 | 8:00AM - 11:15AM
Neurodegeneration Due to RNA and DNA Regulatory Proteins
Room: Chamisa Ballroom 1

Speaker 2 of 7
Virginia M. Y. Lee, University of Pennsylvania School of Medicine, USA
TDP-43 Proteinopathies

Thursday, February 24 | 8:00AM - 11:15AM
Neurodegeneration Due to RNA and DNA Regulatory Proteins
Room: Chamisa Ballroom 1

Speaker 3 of 7
Don W. Cleveland, University of California, San Diego, USA
Rethinking ALS: What's All the FUS?

Thursday, February 24 | 8:00AM - 11:15AM
Neurodegeneration Due to RNA and DNA Regulatory Proteins
Room: Chamisa Ballroom 1

Speaker 4 of 7
Aaron D. Gitler, Stanford University School of Medicine, USA
Novel RNA Binding Proteins in ALS

Thursday, February 24 | 8:00AM - 11:15AM
Neurodegeneration Due to RNA and DNA Regulatory Proteins
Room: Chamisa Ballroom 1

Speaker 5 of 7
Ted M. Dawson, Johns Hopkins University School of Medicine, USA
Parkin, Paris and PGC-1alpha: A Novel Neurodegenerative Pathway in Parkinson's Disease

Thursday, February 24 | 8:00AM - 11:15AM
Neurodegeneration Due to RNA and DNA Regulatory Proteins
Room: Chamisa Ballroom 1

Speaker 6 of 7
Miriam E. Bucheli, Harvard University, Harvard Medical School, USA
Short Talk: A Combinatorial Approach to Identify Common Regulatory Targets for FUS/TLS, TDP-43 and SETX

Thursday, February 24 | 8:00AM - 11:15AM
Neurodegeneration Due to RNA and DNA Regulatory Proteins
Room: Chamisa Ballroom 1

Speaker 7 of 7
Thomas L. Kukar, Emory University, USA
Short Talk: Somatic Brain Transgenic FUS Mice

Thursday, February 24 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Thursday, February 24 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Thursday, February 24 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Thursday, February 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Thursday, February 24 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Thursday, February 24 | 5:00PM - 7:15PM
Bridging Biology to Therapeutics in Neurodegenerative Disord
ers

Room: Chamisa Ballroom 1

Speaker 1 of 7
* John Q. Trojanowski, University of Pennsylvania, USA

Thursday, February 24 | 5:00PM - 7:15PM
Bridging Biology to Therapeutics in Neurodegenerative Disord
ers

Room: Chamisa Ballroom 1

Speaker 2 of 7
Per I. Arvidsson, AstraZeneca R&D, Sweden
Beyond Abeta Based Therapies: Developing Novel Modulators of Synaptic Transmission

Thursday, February 24 | 5:00PM - 7:15PM
Bridging Biology to Therapeutics in Neurodegenerative Disord
ers

Room: Chamisa Ballroom 1

Speaker 3 of 7
Valina L. Dawson, Johns Hopkins University School of Medicine, USA
Inhibitors of LRRK2 Kinase: Mechanism-Based Therapy for Parkinson's Disease

Thursday, February 24 | 5:00PM - 7:15PM
Bridging Biology to Therapeutics in Neurodegenerative Disord
ers

Room: Chamisa Ballroom 1

Speaker 4 of 7
Anatoly Nikolaev, Genentech, USA
Short Talk: APP-Death Receptor Signaling Pathway as a Drug Target in Neurodegenerative Disease

Thursday, February 24 | 5:00PM - 7:15PM
Bridging Biology to Therapeutics in Neurodegenerative Disord
ers

Room: Chamisa Ballroom 1

Speaker 5 of 7
Giovanna R. Mallucci, University of Leicester, UK
Short Talk: Mechanisms of Neurotoxicity in Prion Disease

Thursday, February 24 | 5:00PM - 7:15PM
Bridging Biology to Therapeutics in Neurodegenerative Disord
ers

Room: Chamisa Ballroom 1

Speaker 6 of 7
Harald Neumann, University Bonn, Germany
Short Talk: Human Induced Pluripotent Stem Cell-Derived Microglia (iPSdM) as Tool to Study Neurodegenerative Diseases

Thursday, February 24 | 5:00PM - 7:15PM
Bridging Biology to Therapeutics in Neurodegenerative Disord
ers

Room: Chamisa Ballroom 1

Speaker 7 of 7
Lindsay N. Hayes, Johns Hopkins University, USA
Short Talk: The Timing of Sonic Hedgehog and Gli1 Expression Segregates Midbrain Dopamine Neurons

Thursday, February 24 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Thursday, February 24 | 7:30PM - 10:00PM
Poster Session 3
Room: Chamisa Ballroom 2


Friday, February 25 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Friday, February 25 | 8:00AM - 11:15AM
Prion and Prion-Like Contributions to Neurodegeneration
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Virginia M. Y. Lee, University of Pennsylvania School of Medicine, USA

Friday, February 25 | 8:00AM - 11:15AM
Prion and Prion-Like Contributions to Neurodegeneration
Room: Chamisa Ballroom 1

Speaker 2 of 7
Lary C. Walker, Emory University, USA
Prion-Like Seeding of Cerebral Abeta Deposition in Transgenic Models of Alzheimer-Type Proteopathy

Friday, February 25 | 8:00AM - 11:15AM
Prion and Prion-Like Contributions to Neurodegeneration
Room: Chamisa Ballroom 1

Speaker 3 of 7
Markus Tolnay, Basel University Hospital, Switzerland
Transmission and Spreading of Tauopathy in Transgenic Mouse Brain

Friday, February 25 | 8:00AM - 11:15AM
Prion and Prion-Like Contributions to Neurodegeneration
Room: Chamisa Ballroom 1

Speaker 4 of 7
Eliezer Masliah, University of California, San Diego, USA
Prion-Like Protein Propagation in Synucleonopathies: Prospects for Therapeutical Interventions

Friday, February 25 | 8:00AM - 11:15AM
Prion and Prion-Like Contributions to Neurodegeneration
Room: Chamisa Ballroom 1

Speaker 5 of 7
Stephen M. Strittmatter, Yale University, USA
Abeta Oligomer Initiate Alzheimer’s Disease Process by Binding to Neuronal Surface

Friday, February 25 | 8:00AM - 11:15AM
Prion and Prion-Like Contributions to Neurodegeneration
Room: Chamisa Ballroom 1

Speaker 6 of 7
Jeppe Pedersen Falsig, IRBM Promidis, Italy
Short Talk: Microglia - A Crucial Regulator of Prion Turnover and Neurotoxicity

Friday, February 25 | 8:00AM - 11:15AM
Prion and Prion-Like Contributions to Neurodegeneration
Room: Chamisa Ballroom 1

Speaker 7 of 7
Jorg Tatzelt, Ruhr University Bochum, Germany
Short Talk: The Cellular Prion Protein Mediates Neurotoxic Signaling of beta-Sheet-Rich Conformers Independent of Prion Replication

Friday, February 25 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Friday, February 25 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Friday, February 25 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Friday, February 25 | 5:00PM - 6:45PM
Inducible Pluripotent Stem Cells to Model and Treat Neurodeg
enerative Disorders

Room: Chamisa Ballroom 1

Speaker 1 of 3
* Valina L. Dawson, Johns Hopkins University School of Medicine, USA

Friday, February 25 | 5:00PM - 6:45PM
Inducible Pluripotent Stem Cells to Model and Treat Neurodeg
enerative Disorders

Room: Chamisa Ballroom 1

Speaker 2 of 3
Guo-li Ming, University of Pennsylvania, USA
Modeling Neurodegenerative and Neurodevelopment Disorders with iPS Cells

Friday, February 25 | 5:00PM - 6:45PM
Inducible Pluripotent Stem Cells to Model and Treat Neurodeg
enerative Disorders

Room: Chamisa Ballroom 1

Speaker 3 of 3
Lorenz Studer, Memorial Sloan Kettering Cancer Center, USA
Modeling Pathogenesis and Treatment of Familial Dysautonomic Using Patient-Specific iPSCs

Friday, February 25 | 6:45PM - 7:45PM
Closing Keynote Address
Room: Chamisa Ballroom 1

Speaker 1 of 1
Leroy E. Hood, Institute for Systems Biology, USA
Systems Medicine and Emerging Technology: From Reactive to Proactive (P4) Medicine

Friday, February 25 | 8:00PM - 9:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Friday, February 25 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom 2


Friday, February 25 | 9:00PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom 2


Saturday, February 26 | 10:25AM - 10:25AM
Departure


*Session Chair.