Web Desc
Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction
joint with Obesity
Organizer(s): Deborah M. Muoio and Rosalind A. Coleman
Date: January 12 - 17, 2011
Location: Keystone Resort, Keystone, CO, USA
Educational grant from Lilly USA, LLC, Sponsored by Hoffmann-La Roche, Inc. and Takeda Pharmaceutical Company Limited
Summary of Meeting:
Modern technology has created a favorable climate for the “perfect metabolic storm”. Triggered by lifestyle habits that promote overnutrition and inactivity, Westernized societies are confronting an epidemic surge in the incidence of obesity and its attendant co-morbidities. Foremost among these is type 2 diabetes mellitus, which is projected to reach a global incidence of 300 million cases by the year 2020. This grim epidemiological forecast has inspired intense efforts to unravel the molecular mechanisms that link increasing adiposity to glucose intolerance and metabolic failure. This Diabetes meeting will assemble international leaders and rising stars in diverse biomedical disciplines with common interests in understanding and combating cardiometabolic diseases. The program showcases recent advances in the molecular etiology of obesity-related functional impairments in the major peripheral organs that orchestrate energy flux and glycemic control: skeletal and cardiac muscle, adipose tissue, the liver and the pancreas. Thematic emphasis will center on lipid signaling and lipotoxicity, nutrient sensing, mitochondrial energetics, circadian biology and epigenetics. A major goal of the meeting is to provide a forum that encourages interactions between basic and translational scientists at all career levels to critically evaluate new developments and current controversies. Opportunities for interdisciplinary interactions will be further enhanced by the concurrent meeting on “Obesity and Adipogenesis”, which will share two Keynote Speakers and three plenary sessions with the Diabetes meeting.
Scholarship Deadline: September 17 2010
Discounted Abstract Deadline: September 17 2010
Abstract Deadline: October 15 2010
Discounted Registration Deadline: November 12 2010
We gratefully acknowledge additional support for this conference from:
ALPCO DiagnosticsChemoCentryx, Inc.CovX Research LLC (Pfizer)Educational grant from Lilly USA, LLCHoffmann-La Roche, Inc.Rigel Pharmaceuticals, Inc.Takeda Pharmaceutical Company Limited


Takeshi Kurose
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell Press
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK084688-02
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, January 12 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Wednesday, January 12 | 6:15PM - 7:15PM
Refreshments
Room: Longs Peak Foyer


Wednesday, January 12 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 1 of 4
* Deborah M. Muoio, Duke University Medical Center, USA

Wednesday, January 12 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 2 of 4
* Steven R. Smith, AdventHealth, USA

Wednesday, January 12 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 3 of 4
Stephen O'Rahilly, University of Cambridge, UK
Common Metabolic Disorders: Lessons from Human Genetics

Wednesday, January 12 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 4 of 4
David A. Sinclair, Harvard Medical School, USA
Genetic and Pharmacological Interventions to Treat Age-Related Diseases

Thursday, January 13 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Thursday, January 13 | 8:00AM - 11:00AM
Mitochondrial Bioenergetics in Health and Disease (Joint)
Room: Columbine Ballroom

Speaker 1 of 6
* P. Darrell Neufer, East Carolina University, USA

Thursday, January 13 | 8:00AM - 11:00AM
Mitochondrial Bioenergetics in Health and Disease (Joint)
Room: Columbine Ballroom

Speaker 2 of 6
Daniel P. Kelly, University of Pennsylvania, USA
Networks Controlling Muscle Mitochondrial Function

Thursday, January 13 | 8:00AM - 11:00AM
Mitochondrial Bioenergetics in Health and Disease (Joint)
Room: Columbine Ballroom

Speaker 3 of 6
Mary-Ellen Harper, University of Ottawa, Canada
Mitochondrial Uncoupling: Energy Costs and ROS Control Benefits

Thursday, January 13 | 8:00AM - 11:00AM
Mitochondrial Bioenergetics in Health and Disease (Joint)
Room: Columbine Ballroom

Speaker 4 of 6
Xianwen Yi, University of North Carolina, USA
Short Talk: Does Alpha-Lipoic Acid Retain Body Energy by Regulating Nitric Oxide and Reversing Mitochondrial Dysfunction?

Thursday, January 13 | 8:00AM - 11:00AM
Mitochondrial Bioenergetics in Health and Disease (Joint)
Room: Columbine Ballroom

Speaker 5 of 6
Iain Scott, University of Pittsburgh, USA
Short Talk: A Prokaryote-Derived Mitochondrial Acetyltransferase Counteracts the Respiratory Effects of SIRT3

Thursday, January 13 | 8:00AM - 11:00AM
Mitochondrial Bioenergetics in Health and Disease (Joint)
Room: Columbine Ballroom

Speaker 6 of 6
Bruce M. Spiegelman, Harvard Medical School, USA
Transcriptional Regulation of Adipogenesis and Energy Homeostasis

Thursday, January 13 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, January 13 | 11:15AM - 12:00PM
NIH Sponsored Workshop: NIH Loan-Repayment Program (Joint)
Room: Columbine Ballroom

Speaker 1 of 1
Milton Hernandez, NIAID, National Institutes of Health, USA

Thursday, January 13 | 11:15AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Thursday, January 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Thursday, January 13 | 1:00PM - 1:00PM
On Own for Lunch and Recreation


Thursday, January 13 | 2:30PM - 4:30PM
Workshop 1: Hot Topics in Obesity Mechanisms
This session is from Obesity
Room: Quandry Peak

Speaker 1 of 7
* Antonio J. Vidal-Puig, University of Cambridge, UK


Thursday, January 13 | 2:30PM - 4:30PM
Workshop 1: Hot Topics in Obesity Mechanisms
This session is from Obesity
Room: Quandry Peak

Speaker 2 of 7
Parth Patwari, Brigham and Women's Hospital, USA
The Alpha-Arrestin ARRDC3 Regulates Obesity in Mice and Humans


Thursday, January 13 | 2:30PM - 4:30PM
Workshop 1: Hot Topics in Obesity Mechanisms
This session is from Obesity
Room: Quandry Peak

Speaker 3 of 7
Shwetha Ramachandrappa, Cambridge University, UK
Single Minded 1 (SIM1) in Severe Early Onset Obesity


Thursday, January 13 | 2:30PM - 4:30PM
Workshop 1: Hot Topics in Obesity Mechanisms
This session is from Obesity
Room: Quandry Peak

Speaker 4 of 7
Peter K. Jackson, Stanford University, USA
Ciliopathies and Monogenic Obesity Disorders: Bardet-Biedl Syndrome (BBS) and Tubby Family Proteins Direct GPCR Traffic to the Primary Cilium


Thursday, January 13 | 2:30PM - 4:30PM
Workshop 1: Hot Topics in Obesity Mechanisms
This session is from Obesity
Room: Quandry Peak

Speaker 5 of 7
Clemence Blouet, University of Cambridge, UK
Nutrient Sensing Hypothalamic TXNIP Links Nutrient Excess to Energy Imbalance in Mice


Thursday, January 13 | 2:30PM - 4:30PM
Workshop 1: Hot Topics in Obesity Mechanisms
This session is from Obesity
Room: Quandry Peak

Speaker 6 of 7
Nicole Ehrhardt, Cedars-Sinai Medical Center, USA
Lmf1 Deficiency Causes Lipodystrophy


Thursday, January 13 | 2:30PM - 4:30PM
Workshop 1: Hot Topics in Obesity Mechanisms
This session is from Obesity
Room: Quandry Peak

Speaker 7 of 7
Rebecca E. Mercer, University of Alberta, Canada
Leptin Resistance in the Magel2-null Mouse Model of Prader-Willi Syndrome Precedes the Development of Obesity and is Associated with Increased Melanocortin Responsiveness


Thursday, January 13 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, January 13 | 5:00PM - 7:00PM
Sirtuins, NAD Biology and Circadian Control of Metabolism
Room: Longs/Grays Peak

Speaker 1 of 5
* David A. Sinclair, Harvard Medical School, USA

Thursday, January 13 | 5:00PM - 7:00PM
Sirtuins, NAD Biology and Circadian Control of Metabolism
Room: Longs/Grays Peak

Speaker 2 of 5
Shin-ichiro Imai, Washington University School of Medicine, USA
SIRT1 and NAMPT-Mediated NAD Biosynthesis: Systemic Control of Metabolism and Aging in Mammals

Thursday, January 13 | 5:00PM - 7:00PM
Sirtuins, NAD Biology and Circadian Control of Metabolism
Room: Longs/Grays Peak

Speaker 3 of 5
Matthew D. Hirschey, Duke University, USA
Short Talk: SIRT3 Deficiency Accelerates the Development of the Metabolic Syndrome

Thursday, January 13 | 5:00PM - 7:00PM
Sirtuins, NAD Biology and Circadian Control of Metabolism
Room: Longs/Grays Peak

Speaker 4 of 5
Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Epigenomic Regulation of Circadian Rhythm and Metabolism by Nuclear Receptors

Thursday, January 13 | 5:00PM - 7:00PM
Sirtuins, NAD Biology and Circadian Control of Metabolism
Room: Longs/Grays Peak

Speaker 5 of 5
Ueli Schibler, University of Geneva, Switzerland
The Synchronization of Peripheral Circadian Clocks

Thursday, January 13 | 5:00PM - 7:00PM
The Adipose-Brain Axis
This session is from Obesity
Room: Quandary Peak

Speaker 1 of 3
* Karine Clément, INSERM / Sorbonne Universite, France


Thursday, January 13 | 5:00PM - 7:00PM
The Adipose-Brain Axis
This session is from Obesity
Room: Quandary Peak

Speaker 2 of 3
Randy J. Seeley, University of Michigan, USA
A Role for CNS PPARgamma in the Regulation of Energy Balance


Thursday, January 13 | 5:00PM - 7:00PM
The Adipose-Brain Axis
This session is from Obesity
Room: Quandary Peak

Speaker 3 of 3
Steven R. Smith, AdventHealth, USA
Adipose Tissue Hypoxia in Obesity


Thursday, January 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom


Thursday, January 13 | 7:30PM - 10:00PM
Poster Session 1
Room: Colorado Rockies Ballroom


Friday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Friday, January 14 | 8:00AM - 11:15AM
Insulin Resistance, Mitochondrial Dysfunction and Lipotoxici
ty in Humans

Room: Longs/Grays Peak

Speaker 1 of 6
* Mary-Elizabeth Patti, Joslin Diabetes Center, USA

Friday, January 14 | 8:00AM - 11:15AM
Insulin Resistance, Mitochondrial Dysfunction and Lipotoxici
ty in Humans

Room: Longs/Grays Peak

Speaker 2 of 6
Christoph Handschin, University of Basel, Switzerland
Coordination of Anabolic and Catabolic Pathways in Skeletal Muscle by PGC1Ą

Friday, January 14 | 8:00AM - 11:15AM
Insulin Resistance, Mitochondrial Dysfunction and Lipotoxici
ty in Humans

Room: Longs/Grays Peak

Speaker 3 of 6
K. Sreekumaran Nair, Mayo Clinic, USA
Muscle Mitochondrial Dysfunction and Muscle Insulin Resistance in Diabetes

Friday, January 14 | 8:00AM - 11:15AM
Insulin Resistance, Mitochondrial Dysfunction and Lipotoxici
ty in Humans

Room: Longs/Grays Peak

Speaker 4 of 6
P. Darrell Neufer, East Carolina University, USA
Mitochondrial Bioenergetics, Redox Imbalance and Insulin Resistance

Friday, January 14 | 8:00AM - 11:15AM
Insulin Resistance, Mitochondrial Dysfunction and Lipotoxici
ty in Humans

Room: Longs/Grays Peak

Speaker 5 of 6
Elizabeth J. Parks, University of Missouri, USA
Alterations in Fatty Acid Partitioning during Feeding

Friday, January 14 | 8:00AM - 11:15AM
Insulin Resistance, Mitochondrial Dysfunction and Lipotoxici
ty in Humans

Room: Longs/Grays Peak

Speaker 6 of 6
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Novel Actions of Insulin in Control of Brain and Body Metabolism

Friday, January 14 | 8:00AM - 11:00AM
Gut Nutrient Sensing in the Regulation of Body Weight
This session is from Obesity
Room: Quandary Peak

Speaker 1 of 6
* Randy J. Seeley, University of Michigan, USA


Friday, January 14 | 8:00AM - 11:00AM
Gut Nutrient Sensing in the Regulation of Body Weight
This session is from Obesity
Room: Quandary Peak

Speaker 2 of 6
Elaine Holmes, Imperial College London, UK
The Gut Microbiome in Obesity


Friday, January 14 | 8:00AM - 11:00AM
Gut Nutrient Sensing in the Regulation of Body Weight
This session is from Obesity
Room: Quandary Peak

Speaker 3 of 6
Philip Schauer, Cleveland Clinic Foundation, USA
Obesity Surgery: State-of-the-Art?


Friday, January 14 | 8:00AM - 11:00AM
Gut Nutrient Sensing in the Regulation of Body Weight
This session is from Obesity
Room: Quandary Peak

Speaker 4 of 6
Robert F. Margolskee, Monell Chemical Senses Center, USA
Taste Receptors in Gut Regulate Endocrine Function


Friday, January 14 | 8:00AM - 11:00AM
Gut Nutrient Sensing in the Regulation of Body Weight
This session is from Obesity
Room: Quandary Peak

Speaker 5 of 6
Vincent Aguirre, University of Texas, Southwestern Medical Center, USA
Short Talk: MC4Rs in Autonomic Neurons of the Brainstem Mediate Effects of Gastric Bypass on Diabetes but not Energy Expenditure or Body Weight


Friday, January 14 | 8:00AM - 11:00AM
Gut Nutrient Sensing in the Regulation of Body Weight
This session is from Obesity
Room: Quandary Peak

Speaker 6 of 6
Hua V. Lin, BioFront Therapeutics, China
Short Talk: Short-Chain Fatty Acids Regulate Incretin Secretion & Energy Metabolism and Protect Against Diet Induced Obesity


Friday, January 14 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Friday, January 14 | 11:15AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Friday, January 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Friday, January 14 | 1:00PM - 1:00PM
On Own for Lunch and Recreation


Friday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Friday, January 14 | 5:00PM - 7:00PM
How Adipose Tissue Causes Insulin Resistance (Joint)
Room: Columbine Ballroom

Speaker 1 of 4
Anthony W. Ferrante, Columbia University, USA
Immunology and Metabolism in Adipose Tissue

Friday, January 14 | 5:00PM - 7:00PM
How Adipose Tissue Causes Insulin Resistance (Joint)
Room: Columbine Ballroom

Speaker 2 of 4
Karine Clément, INSERM / Sorbonne Universite, France
Human Adipose Tissue Remodelling and Metabolic Complications

Friday, January 14 | 5:00PM - 7:00PM
How Adipose Tissue Causes Insulin Resistance (Joint)
Room: Columbine Ballroom

Speaker 3 of 4
Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Adipose Tissue Factors: Modulators of Insulin Sensitivity, Inflammation and Apoptosis

Friday, January 14 | 5:00PM - 7:00PM
How Adipose Tissue Causes Insulin Resistance (Joint)
Room: Columbine Ballroom

Speaker 4 of 4
Timo D. Müller, Institute for Diabetes and Obesity, Germany
Short Talk: Sequestosome 1 (P62) Deficiency in Adipose Tissue Leads to Obesity and Glucose Intolerance by Impairing BAT Function in Mice

Friday, January 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom


Friday, January 14 | 7:30PM - 10:00PM
Poster Session 2
Room: Colorado Rockies Ballroom


Saturday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Saturday, January 15 | 8:00AM - 11:00AM
Mechanisms of Metabolic Failure
Room: Longs/Grays Peak

Speaker 1 of 7
* Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA

Saturday, January 15 | 8:00AM - 11:00AM
Mechanisms of Metabolic Failure
Room: Longs/Grays Peak

Speaker 2 of 7
David A. Bernlohr, University of Minnesota, USA
Oxidative Stress and Adipocyte Mitochondrial Dysfunction

Saturday, January 15 | 8:00AM - 11:00AM
Mechanisms of Metabolic Failure
Room: Longs/Grays Peak

Speaker 3 of 7
Seung-Hoi Koo, Korea University, South Korea
Regulation of Hepatic Glucose Output by TORC2/CRTC2

Saturday, January 15 | 8:00AM - 11:00AM
Mechanisms of Metabolic Failure
Room: Longs/Grays Peak

Speaker 4 of 7
Roberta Leonardi, West Virginia University, USA
Short Talk: Gluconeogenesis is Controlled by CoA Levels and PanK1

Saturday, January 15 | 8:00AM - 11:00AM
Mechanisms of Metabolic Failure
Room: Longs/Grays Peak

Speaker 5 of 7
Reuben J. Shaw, The Salk Institute for Biological Studies, USA
Class IIa Histone Deacetylases are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis

Saturday, January 15 | 8:00AM - 11:00AM
Mechanisms of Metabolic Failure
Room: Longs/Grays Peak

Speaker 6 of 7
Deborah M. Muoio, Duke University Medical Center, USA
Mitochondrial Stress and Metabolic Dysfunction in Skeletal Muscle

Saturday, January 15 | 8:00AM - 11:00AM
Mechanisms of Metabolic Failure
Room: Longs/Grays Peak

Speaker 7 of 7
Romain Barres, NNF Center for Basic Metabolic Research, Denmark
Short Talk: Exercise Induces Transient DNA Hypomethylation in Human Skeletal Muscle

Saturday, January 15 | 8:00AM - 11:15AM
Adipose Tissue Architecture
This session is from Obesity
Room: Quandary Peak

Speaker 1 of 6
* Jacqueline M. Stephens, Louisiana State University, USA


Saturday, January 15 | 8:00AM - 11:15AM
Adipose Tissue Architecture
This session is from Obesity
Room: Quandary Peak

Speaker 2 of 6
James G. Granneman, Wayne State University School of Medicine, USA
Imaging the Organization and Trafficking of Lipolytic Proteins


Saturday, January 15 | 8:00AM - 11:15AM
Adipose Tissue Architecture
This session is from Obesity
Room: Quandary Peak

Speaker 3 of 6
David E. James, University of Sydney, Australia
Mapping the Insulin Signalling Network in Adipocytes


Saturday, January 15 | 8:00AM - 11:15AM
Adipose Tissue Architecture
This session is from Obesity
Room: Quandary Peak

Speaker 4 of 6
Matthew J. Brady, University of Chicago, USA
Stranger in a Strange Land: Glycogen Metabolism in Adipose Tissue


Saturday, January 15 | 8:00AM - 11:15AM
Adipose Tissue Architecture
This session is from Obesity
Room: Quandary Peak

Speaker 5 of 6
Justin J. Rochford, University of Aberdeen, UK
Short Talk: The Human Lipodystrophy Protein BSCL2/Seipin Binds the Key Lipogenic Enzyme Lipin 1


Saturday, January 15 | 8:00AM - 11:15AM
Adipose Tissue Architecture
This session is from Obesity
Room: Quandary Peak

Speaker 6 of 6
Xunshan Ding, University of Texas Southwestern Medical Center, USA
Short Talk: beta-Klotho in Adipose Tissue Is Required for the Anti-Obesity Effect of Fibroblast Growth Factor 21 in Mice


Saturday, January 15 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Saturday, January 15 | 11:15AM - 1:00PM
Poster Setup
Room: Colorado Rockies Ballroom


Saturday, January 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Saturday, January 15 | 1:00PM - 1:00PM
On Own for Lunch and Recreation


Saturday, January 15 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Obesity Therapy
This session is from Obesity
Room: Quandary Peak

Speaker 1 of 8
Chenguang Ouyang, Indiana University, USA
Discovery of Peptides Balanced In Glucagon Receptor Antagonism and GLP-1 Agonism. A Search for the Molecular Basis in the Inversion of Activity at Homologous Receptors


Saturday, January 15 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Obesity Therapy
This session is from Obesity
Room: Quandary Peak

Speaker 2 of 8
* Thomas E. Hughes, Zafgen, Inc, USA
Methionine Aminopeptidase 2 (MetAP2) Inhibition Improves Metabolic Control and Causes Loss of Excess Body Weight in Mice, Dogs, and Humans


Saturday, January 15 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Obesity Therapy
This session is from Obesity
Room: Quandary Peak

Speaker 3 of 8
Shirly Pinto, Kallyope, USA
Pharmacological Inhibition of Diacylglycerol Acyltransferase 1 Leads to Weight Loss and Prolongation of GLP-1 Release


Saturday, January 15 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Obesity Therapy
This session is from Obesity
Room: Quandary Peak

Speaker 4 of 8
* Claire M. Steppan, Pfizer, USA
Pharmacological Inhibition to Examine the Role of DGAT1 in Dietary Lipid Absorption in Mice and Man


Saturday, January 15 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Obesity Therapy
This session is from Obesity
Room: Quandary Peak

Speaker 5 of 8
Jennifer L. Lachey, Ember Therapeutics, USA
Characterization of the Thermogenic Program Induced in White Adipose Tissue of HFD-Fed Mice Treated with a Soluble ActRIIB


Saturday, January 15 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Obesity Therapy
This session is from Obesity
Room: Quandary Peak

Speaker 6 of 8
Yong Qi, Sirtris, A GlaxoSmithKline Company, USA
Activation of Sirtuin1 (SIRT1) by the Novel Small Molecule SRT2104 Protects against Diet-Induced Obesity and Improves Glucose Homeostasis by Increasing Fatty Acid and Carbohydrate Oxidation in Mice


Saturday, January 15 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Obesity Therapy
This session is from Obesity
Room: Quandary Peak

Speaker 7 of 8
Andrea R. Nawrocki, Janssen Pharmaceutical, USA
The Metabotropic Glutamate Receptor mGluR8 Modulates Energy Metabolism and Amphetamine Induced Hyperactivity in Mice


Saturday, January 15 | 2:30PM - 4:30PM
Workshop 2: Hot Topics in Obesity Therapy
This session is from Obesity
Room: Quandary Peak

Speaker 8 of 8
Matthias H. Tschöp, Helmholtz Zentrum München and Technische Universität München, Germany
Enhanced Metabolic Benefits of Single Peptides with Nuclear Hormone Pharmacology


Saturday, January 15 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Saturday, January 15 | 5:00PM - 7:00PM
Lipid Trafficking and Signaling
Room: Longs/Grays Peak

Speaker 1 of 5
* David A. Bernlohr, University of Minnesota, USA

Saturday, January 15 | 5:00PM - 7:00PM
Lipid Trafficking and Signaling
Room: Longs/Grays Peak

Speaker 2 of 5
Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA
ACSL1 and Lipid Partitioning

Saturday, January 15 | 5:00PM - 7:00PM
Lipid Trafficking and Signaling
Room: Longs/Grays Peak

Speaker 3 of 5
Rudolf Zechner, University of Graz, Austria
Lipolysis and the Lipid Droplet Signaling to the PPARs/PGC1á

Saturday, January 15 | 5:00PM - 7:00PM
Lipid Trafficking and Signaling
Room: Longs/Grays Peak

Speaker 4 of 5
Hei Sook Sul, University of California, Berkeley, USA
Regulation of Adipocyte Lipolysis

Saturday, January 15 | 5:00PM - 7:00PM
Lipid Trafficking and Signaling
Room: Longs/Grays Peak

Speaker 5 of 5
Saswata Talukdar, Merck Sharp & Dohme, USA
Short Talk: GPR120 is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-Inflammatory and Insulin Sensitizing Effects

Saturday, January 15 | 5:00PM - 7:00PM
JAK-STAT Signaling in Obesity
This session is from Obesity
Room: Quandary Peak

Speaker 1 of 5
* Stephen R. Farmer, Boston University School of Medicine, USA


Saturday, January 15 | 5:00PM - 7:00PM
JAK-STAT Signaling in Obesity
This session is from Obesity
Room: Quandary Peak

Speaker 2 of 5
Jacqueline M. Stephens, Louisiana State University, USA
STATs in Adipocyte Development and Function


Saturday, January 15 | 5:00PM - 7:00PM
JAK-STAT Signaling in Obesity
This session is from Obesity
Room: Quandary Peak

Speaker 3 of 5
Martin G. Myers, Jr., University of Michigan, USA
Molecular and Neural Mechanisms of Leptin Action


Saturday, January 15 | 5:00PM - 7:00PM
JAK-STAT Signaling in Obesity
This session is from Obesity
Room: Quandary Peak

Speaker 4 of 5
Allison W. Xu, University of California, San Francisco, USA
Regulation of Energy Balance and Hepatic Lipid Metabolism by Central Stat3 and PI3K Signaling


Saturday, January 15 | 5:00PM - 7:00PM
JAK-STAT Signaling in Obesity
This session is from Obesity
Room: Quandary Peak

Speaker 5 of 5
Tamara L. Allen, Baker IDI Heart and Diabetes Institute, Australia
Short Talk: Modified IC7, a Designer gp130 Receptor Ligand that improves obesity, Improves High Fat Diet-Induced Insulin Resistance


Saturday, January 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom


Saturday, January 15 | 7:30PM - 10:00PM
Poster Session 3
Room: Colorado Rockies Ballroom


Sunday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Colorado Rockies Ballroom


Sunday, January 16 | 7:30AM - 8:00AM
Poster Setup
Room: Colorado Rockies Ballroom


Sunday, January 16 | 8:00AM - 5:00PM
Poster Viewing
Room: Colorado Rockies Ballroom


Sunday, January 16 | 8:00AM - 11:15AM
Insulin Signaling, Action and Secretion
Room: Longs/Grays Peak

Speaker 1 of 8
* Elizabeth J. Parks, University of Missouri, USA

Sunday, January 16 | 8:00AM - 11:15AM
Insulin Signaling, Action and Secretion
Room: Longs/Grays Peak

Speaker 2 of 8
Laurie J. Goodyear, Joslin Diabetes Center, Harvard Medical School, USA
Exercise-Induced Enhancement of Insulin Action

Sunday, January 16 | 8:00AM - 11:15AM
Insulin Signaling, Action and Secretion
Room: Longs/Grays Peak

Speaker 3 of 8
Jorge L. Ruas, Karolinska Institutet, Sweden
Short Talk: Hypertrophic Effects of the PGC1a4 Isoform on Skeletal Muscle

Sunday, January 16 | 8:00AM - 11:15AM
Insulin Signaling, Action and Secretion
Room: Longs/Grays Peak

Speaker 4 of 8
* Christopher B. Newgard, Duke University Medical Center, USA
In Search of Targets for Restoring beta-Cell Function in Diabetes

Sunday, January 16 | 8:00AM - 11:15AM
Insulin Signaling, Action and Secretion
Room: Longs/Grays Peak

Speaker 5 of 8
Angela M. Hall, Washington University School of Medicine, USA
Short Talk: Suppression of Monoacylglycerol Acyltransferase-1 (Mogat1) Improves Glucose Tolerance in Diet-Induced Obese Mice

Sunday, January 16 | 8:00AM - 11:15AM
Insulin Signaling, Action and Secretion
Room: Longs/Grays Peak

Speaker 6 of 8
Andrew Butler, St. Louis University, USA
Short Talk: Adropin-Deficient Mice Exhibit a Pre-Diabetic Condition and Increased Metabolic Distress with Diet-Induced Obesity

Sunday, January 16 | 8:00AM - 11:15AM
Insulin Signaling, Action and Secretion
Room: Longs/Grays Peak

Speaker 7 of 8
Vijay K. Yechoor, University of Pittsburgh, USA
Short Talk: Bmal1 and beta-Cell Clock are Required for Mitochondrial Function and GSIS

Sunday, January 16 | 8:00AM - 11:15AM
Insulin Signaling, Action and Secretion
Room: Longs/Grays Peak

Speaker 8 of 8
Markus Stoffel, ETH Zürich, Switzerland
MicroRNAs and Regulation of Glucose and Lipid Metabolism

Sunday, January 16 | 8:00AM - 11:15AM
New Players in the Old Game - Adipogenesis
This session is from Obesity
Room: Quandary Peak

Speaker 1 of 7
* Matthew J. Brady, University of Chicago, USA


Sunday, January 16 | 8:00AM - 11:15AM
New Players in the Old Game - Adipogenesis
This session is from Obesity
Room: Quandary Peak

Speaker 2 of 7
Antonio J. Vidal-Puig, University of Cambridge, UK
Allostatic Load and Over-Load in the Context of PPARgamma Ablation


Sunday, January 16 | 8:00AM - 11:15AM
New Players in the Old Game - Adipogenesis
This session is from Obesity
Room: Quandary Peak

Speaker 3 of 7
Evan D. Rosen, Harvard University, USA
Comparative Epigenomic Analysis of Human and Murine Adipogenesis


Sunday, January 16 | 8:00AM - 11:15AM
New Players in the Old Game - Adipogenesis
This session is from Obesity
Room: Quandary Peak

Speaker 4 of 7
Stephen R. Farmer, Boston University School of Medicine, USA
Repression of Gene Programs during the Conversion of Mesenchymal Stem Cells to Adipocytes


Sunday, January 16 | 8:00AM - 11:15AM
New Players in the Old Game - Adipogenesis
This session is from Obesity
Room: Quandary Peak

Speaker 5 of 7
Merlin Crossley, University of New South Wales, Australia
The Transcriptional Regulators: KLF3, C-Terminal Binding Protein Co-Repressor (Ctbp), and Friend of Gata in the Regulation of Adipogenesis


Sunday, January 16 | 8:00AM - 11:15AM
New Players in the Old Game - Adipogenesis
This session is from Obesity
Room: Quandary Peak

Speaker 6 of 7
Kai Ge, NIDDK, National Institutes of Health, USA
Short Talk: Epigenetic Regulation of Adipogenesis by Histone Methylation


Sunday, January 16 | 8:00AM - 11:15AM
New Players in the Old Game - Adipogenesis
This session is from Obesity
Room: Quandary Peak

Speaker 7 of 7
Juliane G. Bogner-Strauss, Graz University of Technology, Austria
Short Talk: Adipocyte Plasma Membrane-Associated Protein (APMAP): A Transmembrane Protein Required for Adipogenesis and Targeted by PPARgamma


Sunday, January 16 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Sunday, January 16 | 11:15AM - 12:00PM
Lunch
Room: Shavano/Red Cloud/Crestone


Sunday, January 16 | 12:00PM - 2:30PM
Poster Session 4
Room: Colorado Rockies Ballroom


Sunday, January 16 | 2:30PM - 4:30PM
Panel: Mechanisms of Insulin Resistance: Recent Advances and
Current Controversies (Joint)
Room: Columbine Ballroom

Speaker 1 of 5
* Christopher B. Newgard, Duke University Medical Center, USA

Sunday, January 16 | 2:30PM - 4:30PM
Panel: Mechanisms of Insulin Resistance: Recent Advances and
Current Controversies (Joint)
Room: Columbine Ballroom

Speaker 2 of 5
Deborah M. Muoio, Duke University Medical Center, USA

Sunday, January 16 | 2:30PM - 4:30PM
Panel: Mechanisms of Insulin Resistance: Recent Advances and
Current Controversies (Joint)
Room: Columbine Ballroom

Speaker 3 of 5
Philipp E. Scherer, University of Texas Southwestern Medical Center, USA

Sunday, January 16 | 2:30PM - 4:30PM
Panel: Mechanisms of Insulin Resistance: Recent Advances and
Current Controversies (Joint)
Room: Columbine Ballroom

Speaker 4 of 5
Laurie J. Goodyear, Joslin Diabetes Center, Harvard Medical School, USA

Sunday, January 16 | 2:30PM - 4:30PM
Panel: Mechanisms of Insulin Resistance: Recent Advances and
Current Controversies (Joint)
Room: Columbine Ballroom

Speaker 5 of 5
Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA

Sunday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Sunday, January 16 | 5:00PM - 7:00PM
Epigenetic Control of Metabolism (Joint)
Room: Columbine Ballroom

Speaker 1 of 4
* Steven R. Smith, AdventHealth, USA

Sunday, January 16 | 5:00PM - 7:00PM
Epigenetic Control of Metabolism (Joint)
Room: Columbine Ballroom

Speaker 2 of 4
Mary-Elizabeth Patti, Joslin Diabetes Center, USA
Developmental Origins of Obesity and Type 2 Diabetes

Sunday, January 16 | 5:00PM - 7:00PM
Epigenetic Control of Metabolism (Joint)
Room: Columbine Ballroom

Speaker 3 of 4
Kevin L. Grove, Novo Nordisk, USA
Programming Metabolic Disease: Effects of Maternal Obesity and Diet

Sunday, January 16 | 5:00PM - 7:00PM
Epigenetic Control of Metabolism (Joint)
Room: Columbine Ballroom

Speaker 4 of 4
Andrew P. Feinberg, Johns Hopkins University School of Medicine, USA
The Epigenetic Basis of Common Human Disease

Sunday, January 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Colorado Rockies Ballroom


Sunday, January 16 | 8:00PM - 11:00PM
Entertainment
Room: Colorado Rockies Ballroom


Sunday, January 16 | 8:00PM - 11:00PM
Cash Bar
Room: Colorado Rockies Ballroom


Monday, January 17 | 10:25AM - 10:25AM
Departure


*Session Chair.