Web Desc
Tuberculosis: Immunology, Cell Biology and Novel Vaccination Strategies
joint with Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics
Organizer(s): Stefan H.E. Kaufmann, Gerhard Walzl and Lalita Ramakrishnan
Date: January 15 - 20, 2011
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation. Sponsored by Novartis Institutes for BioMedical Research
For important information on the coronavirus, please click here
Summary of Meeting:
The global epidemic of Tuberculosis (TB) stems from three main problems: 1) HIV/AIDS (TB is the number one cause of death for HIV-infected individuals); 2) the requirement for long-term multidrug therapy that in turn leads to noncompliance and relapse of transmissible infection; and 3) the only available vaccine BCG affords partial protection against disseminated TB in young children but not against adult pulmonary TB which is the main source of Mycobacterium tuberculosis (Mtb) transmission. Moreover, the outcomes of exposure to Mtb differ vastly even in seemingly immunocompetent individuals; differences in both innate and adaptive immunity appear to modulate outcomes. This meeting will primarily focus on immune responses underlying pathology of and protection against TB. This will pave the way towards a better understanding of basic mechanisms of host defense and also provide the basis for novel intervention strategies. Notably, it will provide information relevant for the design of novel vaccines and strategies to counteract Immune Reconstitution Inflammatory Syndrome (IRIS), which increasingly occurs in HIV/Mtb-infected individuals under antiretroviral therapy. This meeting will take place in parallel with the Keystone Symposia meeting on Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics, which emphasizes the pathogen. These meetings will share a keynote address and four plenary sessions, including a joint session on “Systems Biology”, an innovative and powerful approach that is just starting to be applied to TB research. Hence, these two Keystone Symposia meetings have a shared interest in TB but, at the same time, emphasize different aspects of this complex disease. We are convinced, therefore, that these meetings will attract all scientists and clinicians from the different areas of TB research and will therefore also facilitate the coming together of a wide variety of researchers: wet-lab researchers interested in molecular biology of the pathogen; immunologists and cell biologists focused on the host response; and clinicians developing novel intervention measures including diagnostics, vaccines and drugs.
Global Health Travel Award Deadline: August 24 2010
Scholarship Deadline: September 20 2010
Discounted Abstract Deadline: September 20 2010
Abstract Deadline: October 18 2010
Discounted Registration Deadline: November 15 2010
We gratefully acknowledge additional support for this conference from:
Bill & Melinda Gates FoundationBurroughs Wellcome FundNovartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.


PAULO ANTAS

Rahizan Issa

Ekwaro Obuku, in memory of Dr. John Brian Obuku
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI092856-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, January 15 | 3:00PM - 7:30PM
Registration
Room: BC Foyer


Saturday, January 15 | 6:15PM - 7:15PM
Refreshments
Room: BC Foyer


Saturday, January 15 | 7:15PM - 8:30PM
Welcome and Keynote Address (Joint)
Room: British Columbia Ballroom

Speaker 1 of 3
* Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany

Saturday, January 15 | 7:15PM - 8:30PM
Welcome and Keynote Address (Joint)
Room: British Columbia Ballroom

Speaker 2 of 3
* David R. Sherman, University of Washington, USA

Saturday, January 15 | 7:15PM - 8:30PM
Welcome and Keynote Address (Joint)
Room: British Columbia Ballroom

Speaker 3 of 3
Anthony S. Fauci, NIAID, National Institutes of Health, USA
Tuberculosis in 2011: Major Challenges and Unprecedented Opportunities

Sunday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom, Vancouver Island Room


Sunday, January 16 | 8:00AM - 11:00AM
Tuberculosis Immunology: Bench to Clinic
Room: British Ballroom

Speaker 1 of 5
Joyoti Basu, Bose Institute, India
MicroRNA-mediated Immune Responses in Mycobacterium tuberculosis-infected Macrophages

Sunday, January 16 | 8:00AM - 11:00AM
Tuberculosis Immunology: Bench to Clinic
Room: British Ballroom

Speaker 2 of 5
* Andrea M. Cooper, University of Leicester, UK
Cellular Responses to Mycobacterium tuberculosis in the Mouse Model

Sunday, January 16 | 8:00AM - 11:00AM
Tuberculosis Immunology: Bench to Clinic
Room: British Ballroom

Speaker 3 of 5
Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
Human T Cell Responses to Bacteria

Sunday, January 16 | 8:00AM - 11:00AM
Tuberculosis Immunology: Bench to Clinic
Room: British Ballroom

Speaker 4 of 5
Daniel L. Barber, NIAID, National Institutes of Health, USA
PD-1 Expression by CD4 T Cells is Required for Host Resistance to Mycobacterium tuberculosis

Sunday, January 16 | 8:00AM - 11:00AM
Tuberculosis Immunology: Bench to Clinic
Room: British Ballroom

Speaker 5 of 5
Constance J. Martin, Scholar Rock, USA
Short Talk: Death has its Consequences: Efferocytosis and Control of Tuberculosis

Sunday, January 16 | 8:00AM - 11:00AM
Environmental Sensing, Signaling and Stress Response
This session is from Mycobacteria
Room: Columbia Ballroom

Speaker 1 of 6
* Sabine Ehrt, Weill Cornell Medical College, USA


Sunday, January 16 | 8:00AM - 11:00AM
Environmental Sensing, Signaling and Stress Response
This session is from Mycobacteria
Room: Columbia Ballroom

Speaker 2 of 6
Sarah M. Fortune, Harvard TH Chan School of Public Health, USA
A Time for Change: The Mutation Rate of Mycobacterium tuberculosis during Latent Infection


Sunday, January 16 | 8:00AM - 11:00AM
Environmental Sensing, Signaling and Stress Response
This session is from Mycobacteria
Room: Columbia Ballroom

Speaker 3 of 6
Miriam Braunstein, University of North Carolina at Chapel Hill, USA
The Accessory SecA2 Export System of Mycobacteria


Sunday, January 16 | 8:00AM - 11:00AM
Environmental Sensing, Signaling and Stress Response
This session is from Mycobacteria
Room: Columbia Ballroom

Speaker 4 of 6
Sandhya S. Visweswariah, Indian Institute of Science, India
Cyclic AMP in Mycobacteria


Sunday, January 16 | 8:00AM - 11:00AM
Environmental Sensing, Signaling and Stress Response
This session is from Mycobacteria
Room: Columbia Ballroom

Speaker 5 of 6
Stewart H. Shuman, Memorial Sloan-Kettering Institute, USA
Mechanisms of Mycobacterial dsDNA Break Repair


Sunday, January 16 | 8:00AM - 11:00AM
Environmental Sensing, Signaling and Stress Response
This session is from Mycobacteria
Room: Columbia Ballroom

Speaker 6 of 6
Babak Javid, Tsinghua University School of Medicine, China
Short Talk: Mistranslation is a Source of Adaptive Protein Diversity in Mycobacteria


Sunday, January 16 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Sunday, January 16 | 11:00AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Sunday, January 16 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Sunday, January 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Sunday, January 16 | 2:30PM - 4:30PM
Workshop: Tools for Tuberculosis Pathogenesis and Discovery
of Novel Intervention Measures
This session is from Mycobacteria
Room: British/Columbia Ballroom

Speaker 1 of 8
* David R. Sherman, University of Washington, USA


Sunday, January 16 | 2:30PM - 4:30PM
Workshop: Tools for Tuberculosis Pathogenesis and Discovery
of Novel Intervention Measures
This session is from Mycobacteria
Room: British/Columbia Ballroom

Speaker 2 of 8
Ekaterina Gelman, École Polytechnique Fédérale de Lausanne, Switzerland
Real-Time Single-Cell Analysis of Isoniazid-Mediated Death and Persistence


Sunday, January 16 | 2:30PM - 4:30PM
Workshop: Tools for Tuberculosis Pathogenesis and Discovery
of Novel Intervention Measures
This session is from Mycobacteria
Room: British/Columbia Ballroom

Speaker 3 of 8
Heather L. Torrey, Northeastern University, USA
Characterization of High-Persister Mutants of Mycobacterium tuberculosis


Sunday, January 16 | 2:30PM - 4:30PM
Workshop: Tools for Tuberculosis Pathogenesis and Discovery
of Novel Intervention Measures
This session is from Mycobacteria
Room: British/Columbia Ballroom

Speaker 4 of 8
Dany J. V. Beste, University of Surrey, UK
13C Metabolic Flux Analysis Demonstrates that Mycobacterium tuberculosis is Able to Obtain Additional Carbon by C02 Fixation


Sunday, January 16 | 2:30PM - 4:30PM
Workshop: Tools for Tuberculosis Pathogenesis and Discovery
of Novel Intervention Measures
This session is from Mycobacteria
Room: British/Columbia Ballroom

Speaker 5 of 8
Martin Gengenbacher, Max-Planck-Institute for Infection Biology, Germany
Vitamin B6 Biosynthesis is Essential for Survival and Virulence of Mycobacterium tuberculosis


Sunday, January 16 | 2:30PM - 4:30PM
Workshop: Tools for Tuberculosis Pathogenesis and Discovery
of Novel Intervention Measures
This session is from Mycobacteria
Room: British/Columbia Ballroom

Speaker 6 of 8
Anthony David Baughn, University of Minnesota, USA
Metabolomic Adaptations Underlying Anaerobic Persistence of Mycobacterium tuberculosis


Sunday, January 16 | 2:30PM - 4:30PM
Workshop: Tools for Tuberculosis Pathogenesis and Discovery
of Novel Intervention Measures
This session is from Mycobacteria
Room: British/Columbia Ballroom

Speaker 7 of 8
Helene Botella, Weill Cornell Medical College, USA
Pumping out Heavy Metals: A Strategy Evolved by Mycobacterium tuberculosis to Escape Novel Host Cell Microbicidal Mechanisms


Sunday, January 16 | 2:30PM - 4:30PM
Workshop: Tools for Tuberculosis Pathogenesis and Discovery
of Novel Intervention Measures
This session is from Mycobacteria
Room: British/Columbia Ballroom

Speaker 8 of 8
Christina L. Stallings, Washington University School of Medicine, USA
Regulating rRNA Transcription during Mycobacterium tuberculosis Pathogenesis


Sunday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Sunday, January 16 | 5:00PM - 7:00PM
Phagocyte Defense Mechanisms and Bacterial Evasion Strategie
s (Joint)

Room: British/Columbia Ballroom

Speaker 1 of 5
* Lalita Ramakrishnan, University of Cambridge, UK

Sunday, January 16 | 5:00PM - 7:00PM
Phagocyte Defense Mechanisms and Bacterial Evasion Strategie
s (Joint)

Room: British/Columbia Ballroom

Speaker 2 of 5
Kenneth L. Rock, University of Massachusetts Medical School, USA
Endosomal Fate of Particles and Inflammasome Activation

Sunday, January 16 | 5:00PM - 7:00PM
Phagocyte Defense Mechanisms and Bacterial Evasion Strategie
s (Joint)

Room: British/Columbia Ballroom

Speaker 3 of 5
Eric J. Brown, Genentech, Inc, USA
The Role of EccA1 in Mycobacterium marinum Infection

Sunday, January 16 | 5:00PM - 7:00PM
Phagocyte Defense Mechanisms and Bacterial Evasion Strategie
s (Joint)

Room: British/Columbia Ballroom

Speaker 4 of 5
Thierry Soldati, University of Geneva, Switzerland
Interactions of Pathogenic Mycobacteria with Dictyostelium

Sunday, January 16 | 5:00PM - 7:00PM
Phagocyte Defense Mechanisms and Bacterial Evasion Strategie
s (Joint)

Room: British/Columbia Ballroom

Speaker 5 of 5
Pedro Moura-Alves, Max Planck Institute for Infection Biology, Germany
Short Talk: Systematic Identification of NLR and CARD-Domain Containing Proteins Involved in IL-1b Response to Mycobacterium tuberculosis

Sunday, January 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Sunday, January 16 | 7:30PM - 10:00PM
Poster Session 1
Room: Pacific Ballroom


Monday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom, Vancouver Island Room


Monday, January 17 | 8:00AM - 11:00AM
Fundamentals of Persistence and Granuloma Formation
Room: British Ballroom

Speaker 1 of 6
* Joel D. Ernst, University of California, San Francisco, USA

Monday, January 17 | 8:00AM - 11:00AM
Fundamentals of Persistence and Granuloma Formation
Room: British Ballroom

Speaker 2 of 6
Anne O'Garra, Francis Crick Institute, UK
Regulation of the Immune Response in Tuberculosis: Lessons Learned from Mouse Models and Human Disease

Monday, January 17 | 8:00AM - 11:00AM
Fundamentals of Persistence and Granuloma Formation
Room: British Ballroom

Speaker 3 of 6
John D. MacMicking, Yale University, USA
Native Immunity to Tuberculosis: Host Genetics of the IFN-gamma Response

Monday, January 17 | 8:00AM - 11:00AM
Fundamentals of Persistence and Granuloma Formation
Room: British Ballroom

Speaker 4 of 6
Anca Dorhoi, Friedrich-Loeffler-Institut, Germany
Orchestration of Innate Immunity of Tuberculosis

Monday, January 17 | 8:00AM - 11:00AM
Fundamentals of Persistence and Granuloma Formation
Room: British Ballroom

Speaker 5 of 6
Peter J. Peters, Netherlands Cancer Institute, Netherlands
Translocation to the Cytosol Determines Pathogenicity of Mycobacteria

Monday, January 17 | 8:00AM - 11:00AM
Fundamentals of Persistence and Granuloma Formation
Room: British Ballroom

Speaker 6 of 6
Lee Kozakiewicz, Albert Einstein College of Medicine, USA
Short Talk: The Role of B Cells in Shaping the Host Immune Response to Mycobacterium tuberculosis

Monday, January 17 | 8:00AM - 11:00AM
Molecular and Evolutionary Determinants of Tuberculosis Path
ogenicity
This session is from Mycobacteria

Room: Columbia Ballroom

Speaker 1 of 5
* Sébastien Gagneux, Swiss Tropical and Public Health Institute, Switzerland
Genetic Diversity in Mycobacterium tuberculosis: An Evolutionary Perspective


Monday, January 17 | 8:00AM - 11:00AM
Molecular and Evolutionary Determinants of Tuberculosis Path
ogenicity
This session is from Mycobacteria

Room: Columbia Ballroom

Speaker 2 of 5
Roland Brosch, Institut Pasteur, France
Virulence Traits of Tubercle bacilli: Insights from a (Patho)genomic Perspective


Monday, January 17 | 8:00AM - 11:00AM
Molecular and Evolutionary Determinants of Tuberculosis Path
ogenicity
This session is from Mycobacteria

Room: Columbia Ballroom

Speaker 3 of 5
Tim Stinear, University of Melbourne, Australia
Evolution of Mycobacterial Pathogenicity


Monday, January 17 | 8:00AM - 11:00AM
Molecular and Evolutionary Determinants of Tuberculosis Path
ogenicity
This session is from Mycobacteria

Room: Columbia Ballroom

Speaker 4 of 5
Olivier Neyrolles, IPBS, CNRS-University of Toulouse, France
Mycobacteria Interactions with Host Cells


Monday, January 17 | 8:00AM - 11:00AM
Molecular and Evolutionary Determinants of Tuberculosis Path
ogenicity
This session is from Mycobacteria

Room: Columbia Ballroom

Speaker 5 of 5
Rainer Kalscheuer, Heinrich-Heine-University Duesseldorf, Germany
Short Talk: A Trehalose-Recycling ABC Transporter is Essential for Mycobacterium tuberculosis Virulence


Monday, January 17 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Monday, January 17 | 11:00AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Monday, January 17 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Monday, January 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Monday, January 17 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Monday, January 17 | 5:00PM - 7:00PM
Capacity Building for Clinical Trials (Drugs, Vaccines and D
iagnostics) and Raising Public Awareness (Joint)

Room: British/Columbia Ballroom

Speaker 1 of 5
* Gerhard Walzl, Stellenbosch University, South Africa

Monday, January 17 | 5:00PM - 7:00PM
Capacity Building for Clinical Trials (Drugs, Vaccines and D
iagnostics) and Raising Public Awareness (Joint)

Room: British/Columbia Ballroom

Speaker 2 of 5
Ajit Lalvani, Imperial College London, UK
Probing the Spectrum and Clinical Outcomes of Latent Tuberculosis through Immunology

Monday, January 17 | 5:00PM - 7:00PM
Capacity Building for Clinical Trials (Drugs, Vaccines and D
iagnostics) and Raising Public Awareness (Joint)

Room: British/Columbia Ballroom

Speaker 3 of 5
David Alland, Rutgers University, New Jersey Medical School, USA
The GeneXpert System for Point-of-Care Tuberculosis Diagnosis and Resistance Testing

Monday, January 17 | 5:00PM - 7:00PM
Capacity Building for Clinical Trials (Drugs, Vaccines and D
iagnostics) and Raising Public Awareness (Joint)

Room: British/Columbia Ballroom

Speaker 4 of 5
William R. Bishai, Johns Hopkins School of Medicine and K-RITH, USA
Short Talk: Tuberculosis Research Opportunities in KwaZulu Natal

Monday, January 17 | 5:00PM - 7:00PM
Capacity Building for Clinical Trials (Drugs, Vaccines and D
iagnostics) and Raising Public Awareness (Joint)

Room: British/Columbia Ballroom

Speaker 5 of 5
Mark Harrington, Treatment Action Group, USA
Global TB R&D Investments: Trends and Needs, 2005-2015

Monday, January 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Monday, January 17 | 7:30PM - 10:00PM
Poster Session 2
Room: Pacific Ballroom


Tuesday, January 18 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom, Vancouver Island Room


Tuesday, January 18 | 7:30AM - 8:00AM
Poster Setup
Room: Pacific Ballroom


Tuesday, January 18 | 8:00AM - 5:00PM
Poster Viewing
Room: Pacific Ballroom


Tuesday, January 18 | 8:00AM - 11:00AM
Diagnosis and Vaccines
Room: British Ballroom

Speaker 1 of 6
* Ajit Lalvani, Imperial College London, UK

Tuesday, January 18 | 8:00AM - 11:00AM
Diagnosis and Vaccines
Room: British Ballroom

Speaker 2 of 6
Madhukar Pai, McGill University, Canada
Tuberculosis Diagnosis in 2011: The Good, the Bad and the Ugly

Tuesday, January 18 | 8:00AM - 11:00AM
Diagnosis and Vaccines
Room: British Ballroom

Speaker 3 of 6
Gerhard Walzl, Stellenbosch University, South Africa
Biomarkers for Different Forms of Tuberculosis

Tuesday, January 18 | 8:00AM - 11:00AM
Diagnosis and Vaccines
Room: British Ballroom

Speaker 4 of 6
Anneke C. Hesseling, Desmond Tutu TB Centre, Faculty of Health Sciences, Stellenbosch University, South Africa
Childhood Tuberculosis, Pathogenesis, Diagnosis and Prevention

Tuesday, January 18 | 8:00AM - 11:00AM
Diagnosis and Vaccines
Room: British Ballroom

Speaker 5 of 6
Helen McShane, Jenner Institute, UK
Challenges in Tuberculosis Vaccine Development

Tuesday, January 18 | 8:00AM - 11:00AM
Diagnosis and Vaccines
Room: British Ballroom

Speaker 6 of 6
H. Martin Vordermeier, Animal Health & Veterinary Laboratories Agency, UK
Short Talk: Transcriptional Profiling of Disease Progression in Bovine Tuberculosis and the Identification of Diagnostic Biomarkers: Murine Microarray Studies can Predict Responses in Infected Cattle

Tuesday, January 18 | 8:00AM - 11:00AM
Persistence Strategies
This session is from Mycobacteria
Room: Columbia Ballroom

Speaker 1 of 5
* Christopher M. Sassetti, University of Massachusetts Medical School, USA
Dynamic Regulation of Mycobacterial Cell Wall Synthesis via Ser/Thr Phosphosignalling


Tuesday, January 18 | 8:00AM - 11:00AM
Persistence Strategies
This session is from Mycobacteria
Room: Columbia Ballroom

Speaker 2 of 5
Joeli Marrero, Weill Cornell Medical College, USA
Carbon Metabolism in Mycobacterium tuberculosis during Infection


Tuesday, January 18 | 8:00AM - 11:00AM
Persistence Strategies
This session is from Mycobacteria
Room: Columbia Ballroom

Speaker 3 of 5
Kyu Y. Rhee, Weill Cornell Medical College, USA
Metabolomic Adaptations of Central Carbon Metabolism in Mycobacterium tuberculosis and Implications for Pathogenesis


Tuesday, January 18 | 8:00AM - 11:00AM
Persistence Strategies
This session is from Mycobacteria
Room: Columbia Ballroom

Speaker 4 of 5
Galina V. Mukamolova, University of Leicester, UK
Short Talk: Mycobacterial Death Prevented by Antibiotics


Tuesday, January 18 | 8:00AM - 11:00AM
Persistence Strategies
This session is from Mycobacteria
Room: Columbia Ballroom

Speaker 5 of 5
Marcel A. Behr, McGill University, Canada
Mechanisms of Mycobacterial Immunogenicity


Tuesday, January 18 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Tuesday, January 18 | 11:00AM - 12:00PM
Lunch
Room: Pacific Ballroom


Tuesday, January 18 | 11:30AM - 2:30PM
Poster Session 3
Room: Pacific Ballroom


Tuesday, January 18 | 2:30PM - 4:30PM
Workshop: Bioinformatics and Systems Biology
Room: British/Columbia Ballroom

Speaker 1 of 7
* Johnjoe McFadden, University of Surrey, UK
Introduction

Tuesday, January 18 | 2:30PM - 4:30PM
Workshop: Bioinformatics and Systems Biology
Room: British/Columbia Ballroom

Speaker 2 of 7
Jeroen Maertzdorf, Max Planck Institute for Infection Biology, Germany
Network and Expression Analyses Reveal Functional Clusters of Genes Correlating to Increased FCGR1 Expression in Tuberculosis

Tuesday, January 18 | 2:30PM - 4:30PM
Workshop: Bioinformatics and Systems Biology
Room: British/Columbia Ballroom

Speaker 3 of 7
Jenny Piercy, University of Oxford, UK
Transcriptional Profiling to Predict Vaccine Success or Failure in Bovine Tuberculosis

Tuesday, January 18 | 2:30PM - 4:30PM
Workshop: Bioinformatics and Systems Biology
Room: British/Columbia Ballroom

Speaker 4 of 7
Deepak Kaushal, Tulane National Primate Research Center, USA
Transcriptomics of Primate Tuberculosis Granuloma Lesions: Markers of Latency, Reactivation and Immunity?

Tuesday, January 18 | 2:30PM - 4:30PM
Workshop: Bioinformatics and Systems Biology
Room: British/Columbia Ballroom

Speaker 5 of 7
Poonam Rath, Cornell Medical School, USA
Characterization of Immunomodulatory Genes of Mycobacterium tuberculosis

Tuesday, January 18 | 2:30PM - 4:30PM
Workshop: Bioinformatics and Systems Biology
Room: British/Columbia Ballroom

Speaker 6 of 7
Chuan Wang, Fudan University, China
Comparative Gene Expression Profiles of microRNAs in Persons with Latent and Active Tuberculosis

Tuesday, January 18 | 2:30PM - 4:30PM
Workshop: Bioinformatics and Systems Biology
Room: British/Columbia Ballroom

Speaker 7 of 7
Kathryn Winglee, Johns Hopkins University, USA
A Tool For Rapidly Identifying Strain Differences in Deep Sequencing Data

Tuesday, January 18 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Tuesday, January 18 | 5:00PM - 7:00PM
Systems Biology (Joint)
Room: British/Columbia Ballroom

Speaker 1 of 5
* Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany

Tuesday, January 18 | 5:00PM - 7:00PM
Systems Biology (Joint)
Room: British/Columbia Ballroom

Speaker 2 of 5
D. Branch Moody, Brigham and Women's Hospital, USA
Scanning the Mycobacterium Tuberculosis Lipidome for New Virulence Pathways

Tuesday, January 18 | 5:00PM - 7:00PM
Systems Biology (Joint)
Room: British/Columbia Ballroom

Speaker 3 of 5
Luis Serrano, Centre for Genomic Regulation, Spain
Systems Biology Analysis of a Small Prokaryote Reveals Unexpected Complexity in Prokaryotes

Tuesday, January 18 | 5:00PM - 7:00PM
Systems Biology (Joint)
Room: British/Columbia Ballroom

Speaker 4 of 5
James Galagan, Broad Institute of Massachusetts Institute of Technology and Harvard, USA
The Tuberculosis Systems Biology Consortium

Tuesday, January 18 | 5:00PM - 7:00PM
Systems Biology (Joint)
Room: British/Columbia Ballroom

Speaker 5 of 5
January Weiner, Max Planck Institute of Infection Biology, Germany
Short Talk: Metabolic Network Analysis Helps to Unveil the Biology of Tuberculosis Infection

Tuesday, January 18 | 7:00PM - 7:00PM
On Own for Dinner


Wednesday, January 19 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom, Vancouver Island Room


Wednesday, January 19 | 7:30AM - 8:00AM
Poster Setup
Room: Pacific Ballroom


Wednesday, January 19 | 8:00AM - 5:00PM
Poster Viewing
Room: Pacific Ballroom


Wednesday, January 19 | 8:00AM - 11:30AM
Cellular and Genetic Mechanisms of Host Responses
Room: British Ballroom

Speaker 1 of 7
* Anne O'Garra, Francis Crick Institute, UK

Wednesday, January 19 | 8:00AM - 11:30AM
Cellular and Genetic Mechanisms of Host Responses
Room: British Ballroom

Speaker 2 of 7
Philippe Gros, McGill University, Canada
Forward Genetic Dissection of Early Innate Responses to Pathogens in Mice: IRF8 and Beyond

Wednesday, January 19 | 8:00AM - 11:30AM
Cellular and Genetic Mechanisms of Host Responses
Room: British Ballroom

Speaker 3 of 7
David M. Tobin, Duke University School of Medicine, USA
Eicosanoid Balance Controls Susceptibility to Tuberculosis

Wednesday, January 19 | 8:00AM - 11:30AM
Cellular and Genetic Mechanisms of Host Responses
Room: British Ballroom

Speaker 4 of 7
Robert J. Wilkinson, University of Cape Town, South Africa
Do Hypoxia-Inducible Mycobacterium tuberculosis Genes Encode Useful Antigens?

Wednesday, January 19 | 8:00AM - 11:30AM
Cellular and Genetic Mechanisms of Host Responses
Room: British Ballroom

Speaker 5 of 7
David M. Lewinsohn, Oregon Health & Science University, USA
Immune Recognition of Intracellular Infection with Mycobacterium tuberculosis

Wednesday, January 19 | 8:00AM - 11:30AM
Cellular and Genetic Mechanisms of Host Responses
Room: British Ballroom

Speaker 6 of 7
Ronald N. Germain, NIAID, National Institutes of Health, USA
Dynamic in situ Visualization of Immune System Interactions with Pathogens Using Intravital 2-Photon Microscopy

Wednesday, January 19 | 8:00AM - 11:30AM
Cellular and Genetic Mechanisms of Host Responses
Room: British Ballroom

Speaker 7 of 7
Alissa C. Rothchild, Seattle Children's Research Institute, USA
Short Talk: Antimicrobial Effector Functions of iNKT Cells Activated by Mycobacterium tuberculosis-Infected Macrophages

Wednesday, January 19 | 8:00AM - 11:00AM
Physiology and Intervention
This session is from Mycobacteria
Room: Columbia Ballroom

Speaker 1 of 5
David L. Pompliano, Lodo Therapeutics, USA
The Challenges of Antibacterial Discovery


Wednesday, January 19 | 8:00AM - 11:00AM
Physiology and Intervention
This session is from Mycobacteria
Room: Columbia Ballroom

Speaker 2 of 5
* Stewart T. Cole, Institut Pasteur, France
New Medicines for Tuberculosis (NM4TB): Benzothiazinones


Wednesday, January 19 | 8:00AM - 11:00AM
Physiology and Intervention
This session is from Mycobacteria
Room: Columbia Ballroom

Speaker 3 of 5
John S. Blanchard, Albert Einstein College of Medicine, USA
Structure and Mechanism of Mtb Cyclodityrosine Synthetase


Wednesday, January 19 | 8:00AM - 11:00AM
Physiology and Intervention
This session is from Mycobacteria
Room: Columbia Ballroom

Speaker 4 of 5
Gyanu Lamichhane, Johns Hopkins University, USA
Cross-Linking of the Peptidoglycan: Effect on Physiology of Mycobacterium Tuberculosis


Wednesday, January 19 | 8:00AM - 11:00AM
Physiology and Intervention
This session is from Mycobacteria
Room: Columbia Ballroom

Speaker 5 of 5
Christine Cosma, Cell Press, USA
Short Talk: A Zebrafish Larval Platform for Antitubercular Drug Discovery and Characterization in the Context of Dynamic Granulomatous Infection


Wednesday, January 19 | 9:50AM - 10:10AM
Coffee Break
Room: BC Foyer


Wednesday, January 19 | 11:00AM - 12:30PM
Lunch
Room: Pacific Ballroom


Wednesday, January 19 | 11:30AM - 3:00PM
Poster Session 4
Room: Pacific Ballroom


Wednesday, January 19 | 3:00PM - 3:30PM
Coffee Available
Room: BC Foyer


Wednesday, January 19 | 3:30PM - 6:00PM
The Host-Pathogen Interface (Joint)
Room: British/Columbia Ballroom

Speaker 1 of 6
* John D. MacMicking, Yale University, USA

Wednesday, January 19 | 3:30PM - 6:00PM
The Host-Pathogen Interface (Joint)
Room: British/Columbia Ballroom

Speaker 2 of 6
John R. Chan, Albert Einstein College of Medicine, USA
The Role of B Cells in Shaping the Immune Response to Mycobacterium tuberculosis

Wednesday, January 19 | 3:30PM - 6:00PM
The Host-Pathogen Interface (Joint)
Room: British/Columbia Ballroom

Speaker 3 of 6
Joel D. Ernst, University of California, San Francisco, USA
Limitations and Consequences of Adaptive Immunity in Tuberculosis

Wednesday, January 19 | 3:30PM - 6:00PM
The Host-Pathogen Interface (Joint)
Room: British/Columbia Ballroom

Speaker 4 of 6
Kevin B. Urdahl, Seattle Children's Research Institute, USA
Pathogen-Specific Regulatory T Cells and the Slow-Motion T Cell Response to Mycobacterium tuberculosis Infection

Wednesday, January 19 | 3:30PM - 6:00PM
The Host-Pathogen Interface (Joint)
Room: British/Columbia Ballroom

Speaker 5 of 6
Marc K. Jenkins, University of Minnesota Medical School, USA
How CD4+ T Cells Remember Infections

Wednesday, January 19 | 3:30PM - 6:00PM
The Host-Pathogen Interface (Joint)
Room: British/Columbia Ballroom

Speaker 6 of 6
Paolo Manzanillo, University of California San Francisco, USA
Short Talk: Mycobacterial ESX-1 Secretion System Activates a Host Transcription Factor to Promote Pathogenesis

Wednesday, January 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Wednesday, January 19 | 8:00PM - 11:00PM
Entertainment
Room: Pacific Ballroom


Wednesday, January 19 | 8:00PM - 11:00PM
Cash Bar
Room: Pacific Ballroom


Thursday, January 20 | 10:22AM - 10:22AM
Departure


*Session Chair
†Invited, not yet responded.