Web Desc
Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics
joint with Tuberculosis: Immunology, Cell Biology and Novel Vaccination Strategies
Organizer(s): David R. Sherman and Sabine Ehrt
Date: January 15 - 20, 2011
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation. Sponsored by GlaxoSmithKline
Summary of Meeting:
This meeting will address basic understanding, treatment, and prevention of tuberculosis, with a focus on the physiology, metabolism, and pathogenesis of M. tuberculosis. While the Mycobacteria program is primarily pathogen-focused, we have planned this meeting to run in parallel with the Keystone Symposia meeting on Tuberculosis: Immunology, Cell Biology and Novel Vaccination Strategies, a program focused on the host. In combination, these meetings are designed to attract scientists with interests in both pathogen- and host-focused disciplines, while providing joint sessions each day to encourage and facilitate interactions. For example, we will host a joint session on “Systems Biology”, an innovative and powerful approach that is just starting to be applied to TB research. Joint sessions will also address treatment and prevention of tuberculosis with sessions on drug and vaccine discovery strategies, and capacity-building for clinical trials. Other joint sessions include a focus on the host-pathogen interface. The pairing of the Mycobacteria meeting and the meeting on Tuberculosis – which will share a keynote address, 4 plenary sessions, and 2 workshops – renders this meeting unique and enhances opportunities for exchanges between researchers who do not typically interact. The Mycobacteria meeting is intended to provide a state-of-the-art overview of M. tuberculosis biology and pathogenesis; to highlight the translational implications of this work; to provide researchers with access to relevant data from diverse model systems, topics and levels of investigation; and to help define the most important questions to be addressed.
Global Health Travel Award Deadline: August 24 2010
Scholarship Deadline: September 20 2010
Discounted Abstract Deadline: September 20 2010
Abstract Deadline: October 18 2010
Discounted Registration Deadline: November 15 2010
We gratefully acknowledge additional support for this conference from:
Bill & Melinda Gates FoundationGlaxoSmithKline


Georgi Svetoslavov Slavchev
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI092857-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, January 15 | 3:00PM - 7:30PM
Registration
Room: BC Foyer


Saturday, January 15 | 6:15PM - 7:15PM
Refreshments
Room: BC Foyer


Saturday, January 15 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: British Columbia Ballroom

Speaker 1 of 2
* David R. Sherman, University of Washington, USA

Saturday, January 15 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: British Columbia Ballroom

Speaker 2 of 2
Anthony S. Fauci, NIAID, National Institutes of Health, USA
Tuberculosis in 2011: Major Challenges and Unprecedented Opportunities

Sunday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom, Vancouver Island Room


Sunday, January 16 | 8:00AM - 11:00AM
Environmental Sensing, Signaling and Stress Response
Room: Columbia Ballroom

Speaker 1 of 6
* Sabine Ehrt, Weill Cornell Medical College, USA

Sunday, January 16 | 8:00AM - 11:00AM
Environmental Sensing, Signaling and Stress Response
Room: Columbia Ballroom

Speaker 2 of 6
Sarah M. Fortune, Harvard TH Chan School of Public Health, USA
A Time for Change: The Mutation Rate of Mycobacterium tuberculosis during Latent Infection

Sunday, January 16 | 8:00AM - 11:00AM
Environmental Sensing, Signaling and Stress Response
Room: Columbia Ballroom

Speaker 3 of 6
Miriam Braunstein, University of North Carolina at Chapel Hill, USA
The Accessory SecA2 Export System of Mycobacteria

Sunday, January 16 | 8:00AM - 11:00AM
Environmental Sensing, Signaling and Stress Response
Room: Columbia Ballroom

Speaker 4 of 6
Sandhya S. Visweswariah, Indian Institute of Science, India
Cyclic AMP in Mycobacteria

Sunday, January 16 | 8:00AM - 11:00AM
Environmental Sensing, Signaling and Stress Response
Room: Columbia Ballroom

Speaker 5 of 6
Stewart H. Shuman, Memorial Sloan-Kettering Institute, USA
Mechanisms of Mycobacterial dsDNA Break Repair

Sunday, January 16 | 8:00AM - 11:00AM
Environmental Sensing, Signaling and Stress Response
Room: Columbia Ballroom

Speaker 6 of 6
Babak Javid, University of California San Francisco, USA
Short Talk: Mistranslation is a Source of Adaptive Protein Diversity in Mycobacteria

Sunday, January 16 | 8:00AM - 11:00AM
Tuberculosis Immunology: Bench to Clinic
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 1 of 5
Joyoti Basu, Bose Institute, India
MicroRNA-mediated Immune Responses in Mycobacterium tuberculosis-infected Macrophages


Sunday, January 16 | 8:00AM - 11:00AM
Tuberculosis Immunology: Bench to Clinic
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 2 of 5
* Andrea M. Cooper, University of Leicester, UK
Cellular Responses to Mycobacterium tuberculosis in the Mouse Model


Sunday, January 16 | 8:00AM - 11:00AM
Tuberculosis Immunology: Bench to Clinic
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 3 of 5
Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
Human T Cell Responses to Bacteria


Sunday, January 16 | 8:00AM - 11:00AM
Tuberculosis Immunology: Bench to Clinic
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 4 of 5
Daniel L. Barber, NIAID, National Institutes of Health, USA
PD-1 Expression by CD4 T Cells is Required for Host Resistance to Mycobacterium tuberculosis


Sunday, January 16 | 8:00AM - 11:00AM
Tuberculosis Immunology: Bench to Clinic
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 5 of 5
Constance J. Martin, Scholar Rock, USA
Short Talk: Death has its Consequences: Efferocytosis and Control of Tuberculosis


Sunday, January 16 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Sunday, January 16 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Sunday, January 16 | 11:15AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Sunday, January 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Sunday, January 16 | 2:30PM - 4:30PM
Workshop: Tools for Tuberculosis Pathogenesis and Discovery
of Novel Intervention Measures
Room: British/Columbia Ballroom

Speaker 1 of 8
* David R. Sherman, University of Washington, USA

Sunday, January 16 | 2:30PM - 4:30PM
Workshop: Tools for Tuberculosis Pathogenesis and Discovery
of Novel Intervention Measures
Room: British/Columbia Ballroom

Speaker 2 of 8
Ekaterina Gelman, École Polytechnique Fédérale de Lausanne, Switzerland
Real-Time Single-Cell Analysis of Isoniazid-Mediated Death and Persistence

Sunday, January 16 | 2:30PM - 4:30PM
Workshop: Tools for Tuberculosis Pathogenesis and Discovery
of Novel Intervention Measures
Room: British/Columbia Ballroom

Speaker 3 of 8
Heather L. Torrey, Northeastern University, USA
Characterization of High-Persister Mutants of Mycobacterium tuberculosis

Sunday, January 16 | 2:30PM - 4:30PM
Workshop: Tools for Tuberculosis Pathogenesis and Discovery
of Novel Intervention Measures
Room: British/Columbia Ballroom

Speaker 4 of 8
Dany J. V. Beste, University of Surrey, UK
13C Metabolic Flux Analysis Demonstrates that Mycobacterium tuberculosis is Able to Obtain Additional Carbon by C02 Fixation

Sunday, January 16 | 2:30PM - 4:30PM
Workshop: Tools for Tuberculosis Pathogenesis and Discovery
of Novel Intervention Measures
Room: British/Columbia Ballroom

Speaker 5 of 8
Martin Gengenbacher, Max-Planck-Institute for Infection Biology, Germany
Vitamin B6 Biosynthesis is Essential for Survival and Virulence of Mycobacterium tuberculosis

Sunday, January 16 | 2:30PM - 4:30PM
Workshop: Tools for Tuberculosis Pathogenesis and Discovery
of Novel Intervention Measures
Room: British/Columbia Ballroom

Speaker 6 of 8
Anthony David Baughn, University of Minnesota, USA
Metabolomic Adaptations Underlying Anaerobic Persistence of Mycobacterium tuberculosis

Sunday, January 16 | 2:30PM - 4:30PM
Workshop: Tools for Tuberculosis Pathogenesis and Discovery
of Novel Intervention Measures
Room: British/Columbia Ballroom

Speaker 7 of 8
Helene Botella, Weill Cornell Medical College, USA
Pumping out Heavy Metals: A Strategy Evolved by Mycobacterium tuberculosis to Escape Novel Host Cell Microbicidal Mechanisms

Sunday, January 16 | 2:30PM - 4:30PM
Workshop: Tools for Tuberculosis Pathogenesis and Discovery
of Novel Intervention Measures
Room: British/Columbia Ballroom

Speaker 8 of 8
Christina L. Stallings, Washington University School of Medicine, USA
Regulating rRNA Transcription during Mycobacterium tuberculosis Pathogenesis

Sunday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Sunday, January 16 | 5:00PM - 7:00PM
Phagocyte Defense Mechanisms and Bacterial Evasion Strategie
s (Joint)

Room: British/Columbia Ballroom

Speaker 1 of 5
* Lalita Ramakrishnan, University of Cambridge, UK

Sunday, January 16 | 5:00PM - 7:00PM
Phagocyte Defense Mechanisms and Bacterial Evasion Strategie
s (Joint)

Room: British/Columbia Ballroom

Speaker 2 of 5
Kenneth L. Rock, University of Massachusetts Medical School, USA
Endosomal Fate of Particles and Inflammasome Activation

Sunday, January 16 | 5:00PM - 7:00PM
Phagocyte Defense Mechanisms and Bacterial Evasion Strategie
s (Joint)

Room: British/Columbia Ballroom

Speaker 3 of 5
Eric J. Brown, Genentech, Inc, USA
The Role of EccA1 in Mycobacterium marinum Infection

Sunday, January 16 | 5:00PM - 7:00PM
Phagocyte Defense Mechanisms and Bacterial Evasion Strategie
s (Joint)

Room: British/Columbia Ballroom

Speaker 4 of 5
Thierry Soldati, University of Geneva, Switzerland
Interactions of Pathogenic Mycobacteria with Dictyostelium

Sunday, January 16 | 5:00PM - 7:00PM
Phagocyte Defense Mechanisms and Bacterial Evasion Strategie
s (Joint)

Room: British/Columbia Ballroom

Speaker 5 of 5
Pedro Moura-Alves, Max Planck Institute for Infection Biology, Germany
Short Talk: Systematic Identification of NLR and CARD-Domain Containing Proteins Involved in IL-1b Response to Mycobacterium tuberculosis

Sunday, January 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Sunday, January 16 | 7:30PM - 10:00PM
Poster Session 1
Room: Pacific Ballroom


Monday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom, Vancouver Island Room


Monday, January 17 | 8:00AM - 11:00AM
Molecular and Evolutionary Determinants of Tuberculosis Path
ogenicity

Room: Columbia Ballroom

Speaker 1 of 5
* Sébastien Gagneux, Swiss Tropical and Public Health Institute, Switzerland
Genetic Diversity in Mycobacterium tuberculosis: An Evolutionary Perspective

Monday, January 17 | 8:00AM - 11:00AM
Molecular and Evolutionary Determinants of Tuberculosis Path
ogenicity

Room: Columbia Ballroom

Speaker 2 of 5
Roland Brosch, Institut Pasteur, France
Virulence Traits of Tubercle bacilli: Insights from a (Patho)genomic Perspective

Monday, January 17 | 8:00AM - 11:00AM
Molecular and Evolutionary Determinants of Tuberculosis Path
ogenicity

Room: Columbia Ballroom

Speaker 3 of 5
Tim Stinear, University of Melbourne, Australia
Evolution of Mycobacterial Pathogenicity

Monday, January 17 | 8:00AM - 11:00AM
Molecular and Evolutionary Determinants of Tuberculosis Path
ogenicity

Room: Columbia Ballroom

Speaker 4 of 5
Olivier Neyrolles, IPBS, CNRS-University of Toulouse, France
Mycobacteria Interactions with Host Cells

Monday, January 17 | 8:00AM - 11:00AM
Molecular and Evolutionary Determinants of Tuberculosis Path
ogenicity

Room: Columbia Ballroom

Speaker 5 of 5
Rainer Kalscheuer, Heinrich-Heine-University Duesseldorf, Germany
Short Talk: A Trehalose-Recycling ABC Transporter is Essential for Mycobacterium tuberculosis Virulence

Monday, January 17 | 8:00AM - 11:00AM
Fundamentals of Persistence and Granuloma Formation
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 1 of 6
* Joel D. Ernst, University of California, San Francisco, USA


Monday, January 17 | 8:00AM - 11:00AM
Fundamentals of Persistence and Granuloma Formation
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 2 of 6
Anne O'Garra, Francis Crick Institute, UK
Regulation of the Immune Response in Tuberculosis: Lessons Learned from Mouse Models and Human Disease


Monday, January 17 | 8:00AM - 11:00AM
Fundamentals of Persistence and Granuloma Formation
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 3 of 6
John D. MacMicking, Yale University, USA
Native Immunity to Tuberculosis: Host Genetics of the IFN-gamma Response


Monday, January 17 | 8:00AM - 11:00AM
Fundamentals of Persistence and Granuloma Formation
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 4 of 6
Anca Dorhoi, Friedrich-Loeffler-Institut, Germany
Orchestration of Innate Immunity of Tuberculosis


Monday, January 17 | 8:00AM - 11:00AM
Fundamentals of Persistence and Granuloma Formation
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 5 of 6
Peter J. Peters, Netherlands Cancer Institute, Netherlands
Translocation to the Cytosol Determines Pathogenicity of Mycobacteria


Monday, January 17 | 8:00AM - 11:00AM
Fundamentals of Persistence and Granuloma Formation
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 6 of 6
Lee Kozakiewicz, Albert Einstein College of Medicine, USA
Short Talk: The Role of B Cells in Shaping the Host Immune Response to Mycobacterium tuberculosis


Monday, January 17 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Monday, January 17 | 11:00AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Monday, January 17 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Monday, January 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Monday, January 17 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Monday, January 17 | 5:00PM - 7:00PM
Capacity Building for Clinical Trials (Drugs, Vaccines and D
iagnostics) and Raising Public Awareness (Joint)

Room: British/Columbia Ballroom

Speaker 1 of 5
* Gerhard Walzl, Stellenbosch University, South Africa

Monday, January 17 | 5:00PM - 7:00PM
Capacity Building for Clinical Trials (Drugs, Vaccines and D
iagnostics) and Raising Public Awareness (Joint)

Room: British/Columbia Ballroom

Speaker 2 of 5
Ajit Lalvani, Imperial College London, UK
Probing the Spectrum and Clinical Outcomes of Latent Tuberculosis through Immunology

Monday, January 17 | 5:00PM - 7:00PM
Capacity Building for Clinical Trials (Drugs, Vaccines and D
iagnostics) and Raising Public Awareness (Joint)

Room: British/Columbia Ballroom

Speaker 3 of 5
David Alland, Rutgers University, New Jersey Medical School, USA
The GeneXpert System for Point-of-Care Tuberculosis Diagnosis and Resistance Testing

Monday, January 17 | 5:00PM - 7:00PM
Capacity Building for Clinical Trials (Drugs, Vaccines and D
iagnostics) and Raising Public Awareness (Joint)

Room: British/Columbia Ballroom

Speaker 4 of 5
William R. Bishai, Johns Hopkins School of Medicine and K-RITH, USA
Short Talk: Tuberculosis Research Opportunities in KwaZulu Natal

Monday, January 17 | 5:00PM - 7:00PM
Capacity Building for Clinical Trials (Drugs, Vaccines and D
iagnostics) and Raising Public Awareness (Joint)

Room: British/Columbia Ballroom

Speaker 5 of 5
Mark Harrington, Treatment Action Group, USA
Global TB R&D Investments: Trends and Needs, 2005-2015

Monday, January 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Monday, January 17 | 7:30PM - 10:00PM
Poster Session 2
Room: Pacific Ballroom


Tuesday, January 18 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom, Vancouver Island Room


Tuesday, January 18 | 7:30AM - 8:00AM
Poster Setup
Room: Pacific Ballroom


Tuesday, January 18 | 8:00AM - 5:00PM
Poster Viewing
Room: Pacific Ballroom


Tuesday, January 18 | 8:00AM - 11:00AM
Persistence Strategies
Room: Columbia Ballroom

Speaker 1 of 5
* Christopher M. Sassetti, University of Massachusetts Medical School, USA
Dynamic Regulation of Mycobacterial Cell Wall Synthesis via Ser/Thr Phosphosignalling

Tuesday, January 18 | 8:00AM - 11:00AM
Persistence Strategies
Room: Columbia Ballroom

Speaker 2 of 5
Joeli Marrero, Weill Cornell Medical College, USA
Carbon Metabolism in Mycobacterium tuberculosis during Infection

Tuesday, January 18 | 8:00AM - 11:00AM
Persistence Strategies
Room: Columbia Ballroom

Speaker 3 of 5
Kyu Y. Rhee, Weill Cornell Medical College, USA
Metabolomic Adaptations of Central Carbon Metabolism in Mycobacterium tuberculosis and Implications for Pathogenesis

Tuesday, January 18 | 8:00AM - 11:00AM
Persistence Strategies
Room: Columbia Ballroom

Speaker 4 of 5
Galina V. Mukamolova, University of Leicester, UK
Short Talk: Mycobacterial Death Prevented by Antibiotics

Tuesday, January 18 | 8:00AM - 11:00AM
Persistence Strategies
Room: Columbia Ballroom

Speaker 5 of 5
Marcel A. Behr, McGill University, Canada
Mechanisms of Mycobacterial Immunogenicity

Tuesday, January 18 | 8:00AM - 11:00AM
Diagnosis and Vaccines
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 1 of 6
* Ajit Lalvani, Imperial College London, UK


Tuesday, January 18 | 8:00AM - 11:00AM
Diagnosis and Vaccines
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 2 of 6
Madhukar Pai, McGill University, Canada
Tuberculosis Diagnosis in 2011: The Good, the Bad and the Ugly


Tuesday, January 18 | 8:00AM - 11:00AM
Diagnosis and Vaccines
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 3 of 6
Gerhard Walzl, Stellenbosch University, South Africa
Biomarkers for Different Forms of Tuberculosis


Tuesday, January 18 | 8:00AM - 11:00AM
Diagnosis and Vaccines
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 4 of 6
Anneke C. Hesseling, Desmond Tutu TB Centre, Faculty of Health Sciences, Stellenbosch University, South Africa
Childhood Tuberculosis, Pathogenesis, Diagnosis and Prevention


Tuesday, January 18 | 8:00AM - 11:00AM
Diagnosis and Vaccines
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 5 of 6
Helen McShane, Jenner Institute, UK
Challenges in Tuberculosis Vaccine Development


Tuesday, January 18 | 8:00AM - 11:00AM
Diagnosis and Vaccines
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 6 of 6
H. Martin Vordermeier, Animal Health & Veterinary Laboratories Agency, UK
Short Talk: Transcriptional Profiling of Disease Progression in Bovine Tuberculosis and the Identification of Diagnostic Biomarkers: Murine Microarray Studies can Predict Responses in Infected Cattle


Tuesday, January 18 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Tuesday, January 18 | 11:00AM - 12:00PM
Lunch
Room: Pacific Ballroom


Tuesday, January 18 | 11:30AM - 2:30PM
Poster Session 3
Room: Pacific Ballroom


Tuesday, January 18 | 2:30PM - 4:30PM
Workshop: Bioinformatics and Systems Biology
This session is from TB Immunology & Vaccine Design
Room: British/Columbia Ballroom

Speaker 1 of 7
* Johnjoe McFadden, University of Surrey, UK
Introduction


Tuesday, January 18 | 2:30PM - 4:30PM
Workshop: Bioinformatics and Systems Biology
This session is from TB Immunology & Vaccine Design
Room: British/Columbia Ballroom

Speaker 2 of 7
Jeroen Maertzdorf, Max Planck Institute for Infection Biology, Germany
Network and Expression Analyses Reveal Functional Clusters of Genes Correlating to Increased FCGR1 Expression in Tuberculosis


Tuesday, January 18 | 2:30PM - 4:30PM
Workshop: Bioinformatics and Systems Biology
This session is from TB Immunology & Vaccine Design
Room: British/Columbia Ballroom

Speaker 3 of 7
Jenny Piercy, University of Oxford, UK
Transcriptional Profiling to Predict Vaccine Success or Failure in Bovine Tuberculosis


Tuesday, January 18 | 2:30PM - 4:30PM
Workshop: Bioinformatics and Systems Biology
This session is from TB Immunology & Vaccine Design
Room: British/Columbia Ballroom

Speaker 4 of 7
Deepak Kaushal, Texas Biomedical Research Institute, USA
Transcriptomics of Primate Tuberculosis Granuloma Lesions: Markers of Latency, Reactivation and Immunity?


Tuesday, January 18 | 2:30PM - 4:30PM
Workshop: Bioinformatics and Systems Biology
This session is from TB Immunology & Vaccine Design
Room: British/Columbia Ballroom

Speaker 5 of 7
Poonam Rath, Cornell Medical School, USA
Characterization of Immunomodulatory Genes of Mycobacterium tuberculosis


Tuesday, January 18 | 2:30PM - 4:30PM
Workshop: Bioinformatics and Systems Biology
This session is from TB Immunology & Vaccine Design
Room: British/Columbia Ballroom

Speaker 6 of 7
Chuan Wang, Fudan University, China
Comparative Gene Expression Profiles of microRNAs in Persons with Latent and Active Tuberculosis


Tuesday, January 18 | 2:30PM - 4:30PM
Workshop: Bioinformatics and Systems Biology
This session is from TB Immunology & Vaccine Design
Room: British/Columbia Ballroom

Speaker 7 of 7
Kathryn Winglee, Johns Hopkins University, USA
A Tool For Rapidly Identifying Strain Differences in Deep Sequencing Data


Tuesday, January 18 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Tuesday, January 18 | 5:00PM - 7:00PM
Systems Biology (Joint)
Room: British/Columbia Ballroom

Speaker 1 of 5
* Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany

Tuesday, January 18 | 5:00PM - 7:00PM
Systems Biology (Joint)
Room: British/Columbia Ballroom

Speaker 2 of 5
D. Branch Moody, Brigham and Women's Hospital, USA
Scanning the Mycobacterium Tuberculosis Lipidome for New Virulence Pathways

Tuesday, January 18 | 5:00PM - 7:00PM
Systems Biology (Joint)
Room: British/Columbia Ballroom

Speaker 3 of 5
Luis Serrano, Centre for Genomic Regulation, Spain
Systems Biology Analysis of a Small Prokaryote Reveals Unexpected Complexity in Prokaryotes

Tuesday, January 18 | 5:00PM - 7:00PM
Systems Biology (Joint)
Room: British/Columbia Ballroom

Speaker 4 of 5
James Galagan, Broad Institute of Massachusetts Institute of Technology and Harvard, USA
The Tuberculosis Systems Biology Consortium

Tuesday, January 18 | 5:00PM - 7:00PM
Systems Biology (Joint)
Room: British/Columbia Ballroom

Speaker 5 of 5
January Weiner, Max Planck Institute of Infection Biology, Germany
Short Talk: Metabolic Network Analysis Helps to Unveil the Biology of Tuberculosis Infection

Tuesday, January 18 | 7:00PM - 7:00PM
On Own for Dinner


Wednesday, January 19 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom, Vancouver Island Room


Wednesday, January 19 | 7:30AM - 8:00AM
Poster Setup
Room: Pacific Ballroom


Wednesday, January 19 | 8:00AM - 5:00PM
Poster Viewing
Room: Pacific Ballroom


Wednesday, January 19 | 8:00AM - 11:00AM
Physiology and Intervention
Room: Columbia Ballroom

Speaker 1 of 5
David L. Pompliano, Lodo Therapeutics, USA
The Challenges of Antibacterial Discovery

Wednesday, January 19 | 8:00AM - 11:00AM
Physiology and Intervention
Room: Columbia Ballroom

Speaker 2 of 5
* Stewart T. Cole, Institut Pasteur, France
New Medicines for Tuberculosis (NM4TB): Benzothiazinones

Wednesday, January 19 | 8:00AM - 11:00AM
Physiology and Intervention
Room: Columbia Ballroom

Speaker 3 of 5
John S. Blanchard, Albert Einstein College of Medicine, USA
Structure and Mechanism of Mtb Cyclodityrosine Synthetase

Wednesday, January 19 | 8:00AM - 11:00AM
Physiology and Intervention
Room: Columbia Ballroom

Speaker 4 of 5
Gyanu Lamichhane, Johns Hopkins University, USA
Cross-Linking of the Peptidoglycan: Effect on Physiology of Mycobacterium Tuberculosis

Wednesday, January 19 | 8:00AM - 11:00AM
Physiology and Intervention
Room: Columbia Ballroom

Speaker 5 of 5
Christine Cosma, Cell Press, USA
Short Talk: A Zebrafish Larval Platform for Antitubercular Drug Discovery and Characterization in the Context of Dynamic Granulomatous Infection

Wednesday, January 19 | 8:00AM - 11:30AM
Cellular and Genetic Mechanisms of Host Responses
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 1 of 7
* Anne O'Garra, Francis Crick Institute, UK


Wednesday, January 19 | 8:00AM - 11:30AM
Cellular and Genetic Mechanisms of Host Responses
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 2 of 7
Philippe Gros, McGill University, Canada
Forward Genetic Dissection of Early Innate Responses to Pathogens in Mice: IRF8 and Beyond


Wednesday, January 19 | 8:00AM - 11:30AM
Cellular and Genetic Mechanisms of Host Responses
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 3 of 7
David M. Tobin, Duke University School of Medicine, USA
Eicosanoid Balance Controls Susceptibility to Tuberculosis


Wednesday, January 19 | 8:00AM - 11:30AM
Cellular and Genetic Mechanisms of Host Responses
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 4 of 7
Robert J. Wilkinson, University of Cape Town, South Africa
Do Hypoxia-Inducible Mycobacterium tuberculosis Genes Encode Useful Antigens?


Wednesday, January 19 | 8:00AM - 11:30AM
Cellular and Genetic Mechanisms of Host Responses
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 5 of 7
David M. Lewinsohn, Oregon Health & Science University, USA
Immune Recognition of Intracellular Infection with Mycobacterium tuberculosis


Wednesday, January 19 | 8:00AM - 11:30AM
Cellular and Genetic Mechanisms of Host Responses
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 6 of 7
Ronald N. Germain, NIAID, National Institutes of Health, USA
Dynamic in situ Visualization of Immune System Interactions with Pathogens Using Intravital 2-Photon Microscopy


Wednesday, January 19 | 8:00AM - 11:30AM
Cellular and Genetic Mechanisms of Host Responses
This session is from TB Immunology & Vaccine Design
Room: British Ballroom

Speaker 7 of 7
Alissa C. Rothchild, University of Massachusetts Amherst, USA
Short Talk: Antimicrobial Effector Functions of iNKT Cells Activated by Mycobacterium tuberculosis-Infected Macrophages


Wednesday, January 19 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Wednesday, January 19 | 11:00AM - 12:30PM
Lunch
Room: Pacific Ballroom


Wednesday, January 19 | 11:30AM - 3:00PM
Poster Session 4
Room: Pacific Ballroom


Wednesday, January 19 | 3:00PM - 3:30PM
Coffee Available
Room: BC Foyer


Wednesday, January 19 | 3:30PM - 6:00PM
The Host-Pathogen Interfaction (Joint)
Room: British/Columbia Ballroom

Speaker 1 of 6
* John D. MacMicking, Yale University, USA

Wednesday, January 19 | 3:30PM - 6:00PM
The Host-Pathogen Interfaction (Joint)
Room: British/Columbia Ballroom

Speaker 2 of 6
John R. Chan, Albert Einstein College of Medicine, USA
The Role of B Cells in Shaping the Immune Response to Mycobacterium tuberculosis

Wednesday, January 19 | 3:30PM - 6:00PM
The Host-Pathogen Interfaction (Joint)
Room: British/Columbia Ballroom

Speaker 3 of 6
Joel D. Ernst, University of California, San Francisco, USA
Limitations and Consequences of Adaptive Immunity in Tuberculosis

Wednesday, January 19 | 3:30PM - 6:00PM
The Host-Pathogen Interfaction (Joint)
Room: British/Columbia Ballroom

Speaker 4 of 6
Kevin B. Urdahl, Seattle Children's Research Institute, USA
Pathogen-Specific Regulatory T Cells and the Slow-Motion T Cell Response to Mycobacterium tuberculosis Infection

Wednesday, January 19 | 3:30PM - 6:00PM
The Host-Pathogen Interfaction (Joint)
Room: British/Columbia Ballroom

Speaker 5 of 6
Marc K. Jenkins, University of Minnesota Medical School, USA
How CD4+ T Cells Remember Infections

Wednesday, January 19 | 3:30PM - 6:00PM
The Host-Pathogen Interfaction (Joint)
Room: British/Columbia Ballroom

Speaker 6 of 6
Paolo Manzanillo, University of California San Francisco, USA
Short Talk: Mycobacterial ESX-1 Secretion System Activates a Host Transcription Factor to Promote Pathogenesis

Wednesday, January 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Wednesday, January 19 | 8:00PM - 11:00PM
Entertainment
Room: Pacific Ballroom


Wednesday, January 19 | 8:00PM - 11:00PM
Cash Bar
Room: Pacific Ballroom


Thursday, January 20 | 10:25AM - 10:25AM
Departure


*Session Chair.