Web Desc
Cancer Control by Tumor Suppressors and Immune Effectors
joint with Dendritic Cells and the Initiation of Adaptive Immunity
Organizer(s): Laurence Zitvogel, Anna Karolina Palucka and Mark J. Smyth
Date: February 12 - 17, 2011
Location: Santa Fe Community Convention Center, Santa Fe, NM, USA
Sponsored by Abbott Laboratories and Genzyme Corporation
Summary of Meeting:
The changes in the cell biology of tumor cells are conditioned by epigenetic and genetic reprogramming, genomic instability being an essential feature of both oncogenesis and tumor progression despite intrinsic tumor suppressing barriers. These modifications of cancer cells can be accompanied by the emission of “danger signals” that can be perceived by the innate and cognate immune systems. Likewise, promoting tumor cell death or autophagy may enhance or probe the activation of the immune system. Therefore, unravelling the links between the intrinsic barriers against tumor progression and the extrinsic anticancer checkpoints may contribute to unravelling the key molecular sensors of the host-tumor equilibrium and create novel therapeutic targets. The major objectives will be as follows: 1) examine the molecular links between tumor intrinsic checkpoints (p53, NF-Kappa B, autophagy, DNA damage response…) and immunity or immunosuppression, 2) explore the indirect effects of anticancer therapies (conventional or targeted) on the immune system, 3) describe the rationale for and the potential benefit of novel strategies of cancer vaccines or immunotherapies exploiting this knowledge.
Scholarship Deadline: October 13 2010
Discounted Abstract Deadline: October 13 2010
Abstract Deadline: November 17 2010
Discounted Registration Deadline: December 13 2010
We gratefully acknowledge additional support for this conference from:
Abbott Laboratories
Genentech, Inc.
Genzyme CorporationSAIC
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Celldex Therapeutics, Inc.

GlaxoSmithKline Biologicals
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, February 12 | 3:00PM - 7:30PM
Registration
Room: Sweeney Ballroom Foyer


Saturday, February 12 | 6:15PM - 7:15PM
Refreshments
Room: Sweeney F, Main Level Breakout Rooms


Saturday, February 12 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 3
* Laurence Zitvogel, Institut Gustave Roussy, France

Saturday, February 12 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 3
Michael Karin, University of California, San Diego, USA
Inflammation, Immunity and Cancer

Saturday, February 12 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 3
Jean-Laurent Casanova, Rockefeller University, USA
A Genetic Dissection of Immunity to Infection in Natura

Sunday, February 13 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakout Rooms


Sunday, February 13 | 8:00AM - 11:00AM
Pathogenesis: Cancer and Inflammation
Room: Sweeney Ballroom C-E

Speaker 1 of 5
Wolf-Hervé Fridman, Cordeliers Research Centre, France
Prognostic Significance of Tumor-Invading Immune Effectors and Regulators in Human Malignancies

Sunday, February 13 | 8:00AM - 11:00AM
Pathogenesis: Cancer and Inflammation
Room: Sweeney Ballroom C-E

Speaker 2 of 5
* Robert D. Schreiber, Washington University School of Medicine, USA
Molecular Mechanisms Underlying Cancer Immunoediting

Sunday, February 13 | 8:00AM - 11:00AM
Pathogenesis: Cancer and Inflammation
Room: Sweeney Ballroom C-E

Speaker 3 of 5
Giorgio Trinchieri, NCI, National Institutes of Health, USA
Innate Resistance and Inflammation in Cancer

Sunday, February 13 | 8:00AM - 11:00AM
Pathogenesis: Cancer and Inflammation
Room: Sweeney Ballroom C-E

Speaker 4 of 5
* Drew M. Pardoll, Johns Hopkins University School of Medicine, USA
STAT3, Th17 and Cancer Progression

Sunday, February 13 | 8:00AM - 11:00AM
Pathogenesis: Cancer and Inflammation
Room: Sweeney Ballroom C-E

Speaker 5 of 5
Wael Al Zoughbi, Medical University of Graz, Austria
Short Talk: Downregulation of ATGL Enhances Malignant Tumor Growth, ATGL as a Tumor Suppressor Protein

Sunday, February 13 | 8:00AM - 11:00AM
Origins of Dendritic Cells
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 1 of 5
* Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Title to be Determined


Sunday, February 13 | 8:00AM - 11:00AM
Origins of Dendritic Cells
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 2 of 5
Boris Reizis, New York University Langone Medical Center, USA
Signaling Pathways Regulating Dendritic Cell Development


Sunday, February 13 | 8:00AM - 11:00AM
Origins of Dendritic Cells
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 3 of 5
Steffen Jung, Weizmann Institute of Science, Israel
Differential Functions of Intestinal Mononuclear Phagocytes


Sunday, February 13 | 8:00AM - 11:00AM
Origins of Dendritic Cells
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 4 of 5
Miriam Merad, Mount Sinai School of Medicine, USA
Regulation of Development and Function of Non-Lymphoid Tissue Dendritic Cells


Sunday, February 13 | 8:00AM - 11:00AM
Origins of Dendritic Cells
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 5 of 5
Dimitris Skokos, Regeneron Pharmaceuticals, USA
Short Talk: Notch Signaling in DC-Treg Cross-Talk and Autoimmunity


Sunday, February 13 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney F, Main Level Breakout Rooms


Sunday, February 13 | 11:00AM - 1:00PM
Poster Setup
Room: Sweeney F, Main Level Breakout Rooms


Sunday, February 13 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Sunday, February 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakout Rooms


Sunday, February 13 | 2:30PM - 4:30PM
Workshop 1
Room: Sweeney Ballroom C-E

Speaker 1 of 8
* Mark J. Smyth, QIMR Berghofer Medical Research Institute, Australia

Sunday, February 13 | 2:30PM - 4:30PM
Workshop 1
Room: Sweeney Ballroom C-E

Speaker 2 of 8
Ana Stojanovic, German Cancer Research Center, Germany
Analysis of Tumor Infiltrating Natural Killer Cells

Sunday, February 13 | 2:30PM - 4:30PM
Workshop 1
Room: Sweeney Ballroom C-E

Speaker 3 of 8
Philippe D. Pierre, Centre d'Immunologie Marseille-Luminy, CIML, France
Regulated eIF2alpha Dephosphorylation Impairs Translational Stress Responses in Poly I:C -Activated Dendritic Cells

Sunday, February 13 | 2:30PM - 4:30PM
Workshop 1
Room: Sweeney Ballroom C-E

Speaker 4 of 8
Lionel J. Apetoh, Centre Georges Francois Leclerc, France
Restoration of Anticancer Immune Responses through Selective Inhibition of Myeloid Derived Suppressor Cells

Sunday, February 13 | 2:30PM - 4:30PM
Workshop 1
Room: Sweeney Ballroom C-E

Speaker 5 of 8
Uciane Kimble Scarlett, Dartmouth College, USA
Progressive Abrogation of Early Anti-Tumor Immunity by Dendritic Cells Provides New Opportunities for Novel Diagnostic Interventions

Sunday, February 13 | 2:30PM - 4:30PM
Workshop 1
Room: Sweeney Ballroom C-E

Speaker 6 of 8
Jennifer C. Byrne, Royal College of Surgeons in Ireland, Ireland
Knock-Out of BTK May Promote a Tumor Tolerogenic State through Alteration of TLR Signalling

Sunday, February 13 | 2:30PM - 4:30PM
Workshop 1
Room: Sweeney Ballroom C-E

Speaker 7 of 8
Liat Izhak, National Cancer Institute, National Institutes of Health, USA
The Relative Role of Two Types of Regulatory T Cells in Tumor Immunity : Tregs and Type II NKT Cells

Sunday, February 13 | 2:30PM - 4:30PM
Workshop 1
Room: Sweeney Ballroom C-E

Speaker 8 of 8
George Coukos, University Hospital of Lausanne - CHUV, Switzerland
CCR10+ Regulatory T Cells are Recruited by Hypoxic Tumor Cells via
the CCL28 Chemokine to Promote Immune Tolerance and Angiogenesis in Cancer


Sunday, February 13 | 2:30PM - 4:30PM
Workshop 1: A DC by Any Other Name Would Still Smell as Swee
t
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 1 of 9
* Ken Shortman, Walter and Eliza Hall Institute of Medical Research, Australia


Sunday, February 13 | 2:30PM - 4:30PM
Workshop 1: A DC by Any Other Name Would Still Smell as Swee
t
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 2 of 9
Cheolho Cheong, Institut de Recherches Cliniques de Montreal, Canada
Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas


Sunday, February 13 | 2:30PM - 4:30PM
Workshop 1: A DC by Any Other Name Would Still Smell as Swee
t
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 3 of 9
Alicia Rodriguez-Pla, Baylor Institute for Immunology Research, USA
SLE Serum Synergizes with CD14 Signaling in Generation of CCR-7-Expressing Monocyte-Derived DCs


Sunday, February 13 | 2:30PM - 4:30PM
Workshop 1: A DC by Any Other Name Would Still Smell as Swee
t
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 4 of 9
Jay W. Heinecke, University of Washington School of Medicine, USA
The Plasma Membrane Proteome Unravels Macrophage and Myeloid Dendritic Cell Heterogeneity


Sunday, February 13 | 2:30PM - 4:30PM
Workshop 1: A DC by Any Other Name Would Still Smell as Swee
t
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 5 of 9
Florent Ginhoux, Singapore Immunology Network, Singapore
Langerhans Cells Arise from Yolk Sac Primitive Macrophages during Early Embryonic Development


Sunday, February 13 | 2:30PM - 4:30PM
Workshop 1: A DC by Any Other Name Would Still Smell as Swee
t
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 6 of 9
Sandra Bajaña, Oklahoma Medical Research Foundation, USA
Interferon Regulatory Factor 4 Regulates Tissue Dendritic Cell Migration from the Skin during Homeostasis and upon Inflammation in vivo


Sunday, February 13 | 2:30PM - 4:30PM
Workshop 1: A DC by Any Other Name Would Still Smell as Swee
t
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 7 of 9
Molly Ingersoll, Institut Pasteur, France
Analysis of Antigen-Presenting Cell Trafficking from the Bladder to Lymph Nodes


Sunday, February 13 | 2:30PM - 4:30PM
Workshop 1: A DC by Any Other Name Would Still Smell as Swee
t
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 8 of 9
Kang Liu, Columbia University Medical Center, USA
The Steady State Mouse Brain Contains Dendritic Cells that are Functionally Distinct from Microglia


Sunday, February 13 | 2:30PM - 4:30PM
Workshop 1: A DC by Any Other Name Would Still Smell as Swee
t
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 9 of 9
Milena Bogunovic, University of Massachusetts Medical School, USA
Homeostasis and Function of Intestinal Muscularis Dendritic Cells


Sunday, February 13 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney F, Main Level Breakout Rooms


Sunday, February 13 | 5:00PM - 7:00PM
Innate Immunity Against Cancer
Room: Sweeney Ballroom C-E

Speaker 1 of 4
Vassili Soumelis, Institut Curie, France
Plasmacytoid DC-Tumor Interactions in Humans

Sunday, February 13 | 5:00PM - 7:00PM
Innate Immunity Against Cancer
Room: Sweeney Ballroom C-E

Speaker 2 of 4
Carl G. Figdor, Radboud University Medical Center, Netherlands
Human Plasmacytoid DC in Cancer and Cancer Immunotherapy

Sunday, February 13 | 5:00PM - 7:00PM
Innate Immunity Against Cancer
Room: Sweeney Ballroom C-E

Speaker 3 of 4
* Mark J. Smyth, QIMR Berghofer Medical Research Institute, Australia
NK/NKT Cell Receptor-Mediated Immunosurveillance

Sunday, February 13 | 5:00PM - 7:00PM
Innate Immunity Against Cancer
Room: Sweeney Ballroom C-E

Speaker 4 of 4
Stephen B. Willingham, Corvus Pharmaceuticals, USA
Short Talk: Efficacy of Anti-CD47 Antibody Therapy for Human Solid Tumors

Sunday, February 13 | 5:00PM - 7:15PM
Mechanisms of Antigen Processing by Dendritic Cells
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 1 of 4
* Ira Mellman, Genentech, Inc., USA
Endosomes and Antigen Presentation by Dendritic Cells


Sunday, February 13 | 5:00PM - 7:15PM
Mechanisms of Antigen Processing by Dendritic Cells
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 2 of 4
Hidde L. Ploegh, Boston Children's Hospital, USA
Title to be Determined


Sunday, February 13 | 5:00PM - 7:15PM
Mechanisms of Antigen Processing by Dendritic Cells
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 3 of 4
Sebastian Amigorena, Institut Curie, France
Antigen Cross Presentation in DCs


Sunday, February 13 | 5:00PM - 7:15PM
Mechanisms of Antigen Processing by Dendritic Cells
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 4 of 4
Pierre Guermonprez, Kings College London, UK
Short Talk


Sunday, February 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakout Rooms


Sunday, February 13 | 7:30PM - 10:00PM
Poster Session 1
Room: Sweeney F, Main Level Breakout Rooms


Monday, February 14 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakout Rooms


Monday, February 14 | 8:00AM - 11:15AM
Harnessing the Cell Biology of Dendritic Cells against Cance
r (Joint)

Room: Sweeney Ballroom A-E

Speaker 1 of 8
* Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland

Monday, February 14 | 8:00AM - 11:15AM
Harnessing the Cell Biology of Dendritic Cells against Cance
r (Joint)

Room: Sweeney Ballroom A-E

Speaker 2 of 8
Yong-Jun Liu, Sanofi, USA
Identification of DNA/RNA Sensors in DCs

Monday, February 14 | 8:00AM - 11:15AM
Harnessing the Cell Biology of Dendritic Cells against Cance
r (Joint)

Room: Sweeney Ballroom A-E

Speaker 3 of 8
Caetano Reis e Sousa, Francis Crick Institute, UK
Harnessing DC Biology Against Cancer

Monday, February 14 | 8:00AM - 11:15AM
Harnessing the Cell Biology of Dendritic Cells against Cance
r (Joint)

Room: Sweeney Ballroom A-E

Speaker 4 of 8
Madhav V. Dhodapkar, Yale School of Medicine, USA
Dual Face of DCs in Cancer

Monday, February 14 | 8:00AM - 11:15AM
Harnessing the Cell Biology of Dendritic Cells against Cance
r (Joint)

Room: Sweeney Ballroom A-E

Speaker 5 of 8
Kangling Xu, Baylor Institute for Immunology Research, USA
Short Talk: TSLP Driven Inflammation Fosters Breast Tumor Development

Monday, February 14 | 8:00AM - 11:15AM
Harnessing the Cell Biology of Dendritic Cells against Cance
r (Joint)

Room: Sweeney Ballroom A-E

Speaker 6 of 8
Jolanda de Vries, NCMLS, Radboud University Medical Center, Netherlands
Short Talk: Imaging Early Immune Responses in Cancer Patients after DC Vaccination

Monday, February 14 | 8:00AM - 11:15AM
Harnessing the Cell Biology of Dendritic Cells against Cance
r (Joint)

Room: Sweeney Ballroom A-E

Speaker 7 of 8
Christopher E. Rudd, University of Montreal, Canada
Short Talk: CTLA-4 Modulation of T-Cell-DC Interactions

Monday, February 14 | 8:00AM - 11:15AM
Harnessing the Cell Biology of Dendritic Cells against Cance
r (Joint)

Room: Sweeney Ballroom A-E

Speaker 8 of 8
Hideki Ueno, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Generation of T Follicular Helper Cells by DCs in Humans

Monday, February 14 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney F, Main Level Breakout Rooms


Monday, February 14 | 11:15AM - 1:00PM
Poster Setup
Room: Sweeney F, Main Level Breakout Rooms


Monday, February 14 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, February 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakout Rooms


Monday, February 14 | 2:30PM - 4:30PM
Workshop 2: Immune Status Response at Different Stages of Tu
mor Development and Progression
Room: Sweeney Ballroom C-E

Speaker 1 of 7
* A. Karolina Palucka, The Jackson Laboratory for Genomic Medicine, USA

Monday, February 14 | 2:30PM - 4:30PM
Workshop 2: Immune Status Response at Different Stages of Tu
mor Development and Progression
Room: Sweeney Ballroom C-E

Speaker 2 of 7
Kenneth Nally, University College Cork, Ireland
Regulation of a Putative Tumor Suppressor Gene BCL-G by Pro Inflammatory Cytokines in Intestinal Epithelial Cells

Monday, February 14 | 2:30PM - 4:30PM
Workshop 2: Immune Status Response at Different Stages of Tu
mor Development and Progression
Room: Sweeney Ballroom C-E

Speaker 3 of 7
Stefanie Regine Dannenmann, University Hospital Zürich, Switzerland
Immunoregulation of Tumor-Specific T Cell Responses in Clear Cell Renal Cell Carcinoma (ccRCC)

Monday, February 14 | 2:30PM - 4:30PM
Workshop 2: Immune Status Response at Different Stages of Tu
mor Development and Progression
Room: Sweeney Ballroom C-E

Speaker 4 of 7
Joseph Edward Qualls, Cincinnati Children's Hospital Medical Center, USA
Tumor Infiltrating Macrophages Acquire Similar Traits Independent of Tumor Type and Location

Monday, February 14 | 2:30PM - 4:30PM
Workshop 2: Immune Status Response at Different Stages of Tu
mor Development and Progression
Room: Sweeney Ballroom C-E

Speaker 5 of 7
Dinesh Chandra, Albert Einstein College of Medicine, USA
Listeria Takes Control Over MDSC in the Tumor Microenvironment and Improves Anti-Tumor Immunity

Monday, February 14 | 2:30PM - 4:30PM
Workshop 2: Immune Status Response at Different Stages of Tu
mor Development and Progression
Room: Sweeney Ballroom C-E

Speaker 6 of 7
Brent A. Hanks, Duke University Medical Center, USA
Loss of the Type III TGF-beta Receptor Tumor Suppressor during Breast Cancer Progression Generates an Immunotolerant Tumor Microenvironment

Monday, February 14 | 2:30PM - 4:30PM
Workshop 2: Immune Status Response at Different Stages of Tu
mor Development and Progression
Room: Sweeney Ballroom C-E

Speaker 7 of 7
Eric R. Lutz, Johns Hopkins University, USA
Higher Avidity Mesothelin-Specific CD8+ T Cell Repertoires are Associated with Longer Disease-Free Survival and Tumor-Trafficking in Patients Treated with a GM-CSF-Secreting Pancreatic Tumor Vaccine

Monday, February 14 | 2:30PM - 4:30PM
Workshop 2: Antigen Processing and Presentation
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 1 of 10
* Jose A. Villadangos, University of Melbourne, Australia


Monday, February 14 | 2:30PM - 4:30PM
Workshop 2: Antigen Processing and Presentation
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 2 of 10
* Philippe D. Pierre, Centre d'Immunologie Marseille-Luminy, CIML, France


Monday, February 14 | 2:30PM - 4:30PM
Workshop 2: Antigen Processing and Presentation
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 3 of 10
Amanda L. Blasius, Novo Nordisk Research Center, USA
Slc15a4, AP-3 and Hermansky-Pudlak Syndrome Proteins are Required for TLR Signaling in Plasmacytoid Dendritic Cells


Monday, February 14 | 2:30PM - 4:30PM
Workshop 2: Antigen Processing and Presentation
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 4 of 10
Misako Matsumoto, Hokkaido University Graduate School of Medicine, Japan
Raftlin is Essential for Poly(I:C) Cellular Uptake in Human Myeloid Dendritic Cells


Monday, February 14 | 2:30PM - 4:30PM
Workshop 2: Antigen Processing and Presentation
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 5 of 10
Diana Matheoud, Université de Montréal, Canada
Dendritic Cells Acquire Antigens Through a New Mechanism of Endocytosis Involving Gap Junctions


Monday, February 14 | 2:30PM - 4:30PM
Workshop 2: Antigen Processing and Presentation
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 6 of 10
Adriana R. Mantegazza, Children's Hospital of Philadelphia, USA
Adaptor Protein 3 (AP-3) Regulates Processing of Phagocytosed Antigen for Presentation by MHC Class II Molecules


Monday, February 14 | 2:30PM - 4:30PM
Workshop 2: Antigen Processing and Presentation
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 7 of 10
Berta Bosch, National Cancer Institute, National Institutes of Health, USA
Clustering Enhances the Quality of MHC-II-Peptide Complex-Stimulation of CD4 T Lymphocytes by Dendritic Cells


Monday, February 14 | 2:30PM - 4:30PM
Workshop 2: Antigen Processing and Presentation
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 8 of 10
Erika Darrah, Johns Hopkins University, USA
Cleavage of Peptidyl Arginine Deiminase IV by Granzyme B Induces Discrete Structural Changes and Influences Epitope Selection


Monday, February 14 | 2:30PM - 4:30PM
Workshop 2: Antigen Processing and Presentation
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 9 of 10
Guenther Baravalle, University of California, San Francisco, USA
MARCH1-Mediated Ubiquitination Regulates CD86 Expression in Dendritic Cells in the Steady and Inflammatory States


Monday, February 14 | 2:30PM - 4:30PM
Workshop 2: Antigen Processing and Presentation
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 10 of 10
Jessica Ma, Genentech, USA
Ubiquitination Regulates MHC-II Transport in Antigen Presenting Cells


Monday, February 14 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney F, Main Level Breakout Rooms


Monday, February 14 | 5:00PM - 7:00PM
Adaptive Immunity against Cancer?
Room: Sweeney Ballroom C-E

Speaker 1 of 4
Richard A. Flavell, HHMI/Yale University School of Medicine, USA
The Role of Inflammasome in Cancer

Monday, February 14 | 5:00PM - 7:00PM
Adaptive Immunity against Cancer?
Room: Sweeney Ballroom C-E

Speaker 2 of 4
* Glenn Dranoff, Novartis Institutes for BioMedical Research, USA
Mechanisms of Protective Tumor Immunity

Monday, February 14 | 5:00PM - 7:00PM
Adaptive Immunity against Cancer?
Room: Sweeney Ballroom C-E

Speaker 3 of 4
Nicholas P. Restifo, Lyell, USA
Adoptive Transfer of “Stem Cell-Like” Anti-Tumor T Cells can Eradicate Tumors

Monday, February 14 | 5:00PM - 7:00PM
Adaptive Immunity against Cancer?
Room: Sweeney Ballroom C-E

Speaker 4 of 4
Li Wang, Medical College of Wisconsin, USA
Short Talk: VISTA, a Novel Ig-Superfamily Ligand that Negatively Regulates T Cell Responses

Monday, February 14 | 5:00PM - 7:00PM
Mechanisms and Consequences of Antigen Presentation by Dendr
itic Cells
This session is from Dendritic Cells

Room: Sweeney Ballroom A-B

Speaker 1 of 5
* Michel C. Nussenzweig, HHMI/Rockefeller University, USA


Monday, February 14 | 5:00PM - 7:00PM
Mechanisms and Consequences of Antigen Presentation by Dendr
itic Cells
This session is from Dendritic Cells

Room: Sweeney Ballroom A-B

Speaker 2 of 5
Gillian Griffiths, Cambridge Institute for Medical Research, UK
Innate to Adaptive: How to Deliver the Lethal Hit


Monday, February 14 | 5:00PM - 7:00PM
Mechanisms and Consequences of Antigen Presentation by Dendr
itic Cells
This session is from Dendritic Cells

Room: Sweeney Ballroom A-B

Speaker 3 of 5
Bali Pulendran, Stanford University School of Medicine, USA
Learning Immunology from Successful Vaccines


Monday, February 14 | 5:00PM - 7:00PM
Mechanisms and Consequences of Antigen Presentation by Dendr
itic Cells
This session is from Dendritic Cells

Room: Sweeney Ballroom A-B

Speaker 4 of 5
Anna Smed Sörensen, Karolinska Institutet, Sweden
Short Talk: Influenza A Virus Infection of Human Primary Dendritic Cells Impairs their Ability to Cross-Present Antigen to CD8 T Cells


Monday, February 14 | 5:00PM - 7:00PM
Mechanisms and Consequences of Antigen Presentation by Dendr
itic Cells
This session is from Dendritic Cells

Room: Sweeney Ballroom A-B

Speaker 5 of 5
Gerben Bouma, Institute of Child Health, UK
Short Talk: Cytoskeletal Remodelling Mediated by WASp in DC is Required for Formation and Function of the Immunological Synapse


Monday, February 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakout Rooms


Monday, February 14 | 7:30PM - 10:00PM
Poster Session 2
Room: Sweeney F, Main Level Breakout Rooms


Tuesday, February 15 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakout Rooms


Tuesday, February 15 | 8:00AM - 11:00AM
Clearance of Dying Cells
Room: Sweeney Ballroom C-E

Speaker 1 of 5
Kodi S. Ravichandran, University of Virginia, USA
Signaling to Engulfment: The Beginnings of a Good Apoptotic Meal

Tuesday, February 15 | 8:00AM - 11:00AM
Clearance of Dying Cells
Room: Sweeney Ballroom C-E

Speaker 2 of 5
Shigekazu Nagata, IFReC, Osaka University, Japan
Apoptosis and Autoimmunity

Tuesday, February 15 | 8:00AM - 11:00AM
Clearance of Dying Cells
Room: Sweeney Ballroom C-E

Speaker 3 of 5
* Douglas R. Green, St. Jude Children's Research Hospital, USA
How Caspase-8 Keeps Cells and Mice Alive

Tuesday, February 15 | 8:00AM - 11:00AM
Clearance of Dying Cells
Room: Sweeney Ballroom C-E

Speaker 4 of 5
Dean Walton Felsher, Stanford University, USA
Essential Role for CD4+ T-Cells in Oncogene Addiction

Tuesday, February 15 | 8:00AM - 11:00AM
Clearance of Dying Cells
Room: Sweeney Ballroom C-E

Speaker 5 of 5
Yi Feng, University of Bristol, UK
Short Talk: Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Initiation of a “Trophic” Inflammatory Response

Tuesday, February 15 | 8:00AM - 11:15AM
Dendritic Cells in Tolerance, Inflammation and Autoimmunity
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 1 of 5
* Virginia Pascual, Cornell University, USA
Neutrophil-Induced pDC Activation in SLE


Tuesday, February 15 | 8:00AM - 11:15AM
Dendritic Cells in Tolerance, Inflammation and Autoimmunity
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 2 of 5
Fiona M. Powrie, University of Oxford, UK
Gut Reactions: Dendritic Cells in the Intestine in Health and Disease


Tuesday, February 15 | 8:00AM - 11:15AM
Dendritic Cells in Tolerance, Inflammation and Autoimmunity
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 3 of 5
Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
Monocytes as Antigen Presenting Cells for Induction of T Cell Response to Microbes


Tuesday, February 15 | 8:00AM - 11:15AM
Dendritic Cells in Tolerance, Inflammation and Autoimmunity
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 4 of 5
Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA
Infection and Apoptosis as a Combined Inflammatory Trigger


Tuesday, February 15 | 8:00AM - 11:15AM
Dendritic Cells in Tolerance, Inflammation and Autoimmunity
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 5 of 5
Mirjam Kool, Erasmus MC, Netherlands
Short Talk: The Ubiquitin Modifying Enzyme A20 is Essential for Suppressing Dendritic Cell Activation and Systemic Autoimmunity


Tuesday, February 15 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney F, Main Level Breakout Rooms


Tuesday, February 15 | 11:00AM - 1:00PM
Poster Setup
Room: Sweeney F, Main Level Breakout Rooms


Tuesday, February 15 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Tuesday, February 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakout Rooms


Tuesday, February 15 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney F, Main Level Breakout Rooms


Tuesday, February 15 | 5:00PM - 7:15PM
Immunosuppressive Components
Room: Sweeney Ballroom C-E

Speaker 1 of 5
Laurence Zitvogel, Institut Gustave Roussy, France
Unraveling the Key-Lock Paradigm of the Immunogenicity of Cell Death

Tuesday, February 15 | 5:00PM - 7:15PM
Immunosuppressive Components
Room: Sweeney Ballroom C-E

Speaker 2 of 5
Mario P. Colombo, Fondazione IRCCS Istituto Nazionale Tumori, Italy
Cells and Matricellular Proteins Accomplices in Tumor Development

Tuesday, February 15 | 5:00PM - 7:15PM
Immunosuppressive Components
Room: Sweeney Ballroom C-E

Speaker 3 of 5
Ursula Grohmann, University of Perugia, Italy
Spotlight on IDO: Tryptophan Catabolism and Beyond

Tuesday, February 15 | 5:00PM - 7:15PM
Immunosuppressive Components
Room: Sweeney Ballroom C-E

Speaker 4 of 5
John Stagg, University of Montréal, Canada
Short Talk: Host-Derived and Tumor-Derived CD73 Promotes Immune Escape and Metastasis

Tuesday, February 15 | 5:00PM - 7:15PM
Immunosuppressive Components
Room: Sweeney Ballroom C-E

Speaker 5 of 5
Lionel J. Apetoh, Centre Georges Francois Leclerc, France
Short Talk: CD39 and CD73 Expression on Th17 Cells Suppress Antitumor Immunity

Tuesday, February 15 | 5:00PM - 7:00PM
Sensing Innate Signals by Dendritic Cells and Other Cells
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 1 of 6
* Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland


Tuesday, February 15 | 5:00PM - 7:00PM
Sensing Innate Signals by Dendritic Cells and Other Cells
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 2 of 6
Matthew Collin, Newcastle University, UK
Dendritic Cell Immunodeficiency in Humans


Tuesday, February 15 | 5:00PM - 7:00PM
Sensing Innate Signals by Dendritic Cells and Other Cells
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 3 of 6
Jürg Tschopp, University of Lausanne, Switzerland
Inflammasomes


Tuesday, February 15 | 5:00PM - 7:00PM
Sensing Innate Signals by Dendritic Cells and Other Cells
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 4 of 6
Christian Münz, University of Zurich, Switzerland
Short Talk: Macroautophagy in Antigen Processing for MHC Presentation


Tuesday, February 15 | 5:00PM - 7:00PM
Sensing Innate Signals by Dendritic Cells and Other Cells
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 5 of 6
Kenya Honda, Keio University School of Medicine, Japan
Short Talk: Commensal Bacteria-Mediated Treg Induction


Tuesday, February 15 | 5:00PM - 7:00PM
Sensing Innate Signals by Dendritic Cells and Other Cells
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 6 of 6
Nicolas Chevrier, Harvard University, USA
Short Talk: Systematic Discovery of Signaling Components Identifies New Branches in Mammalian Viral-Sensing Pathways


Tuesday, February 15 | 7:15PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakout Rooms


Tuesday, February 15 | 7:30PM - 10:00PM
Poster Session 3
Room: Sweeney F, Main Level Breakout Rooms


Wednesday, February 16 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakout Rooms


Wednesday, February 16 | 8:00AM - 11:15AM
Cancer Vaccines: Prophylaxy or Therapy
Room: Sweeney Ballroom C-E

Speaker 1 of 6
* A. Karolina Palucka, The Jackson Laboratory for Genomic Medicine, USA
DC Vaccine Update

Wednesday, February 16 | 8:00AM - 11:15AM
Cancer Vaccines: Prophylaxy or Therapy
Room: Sweeney Ballroom C-E

Speaker 2 of 6
Giorgio Parmiani, Fondazione Centro San Raffaele Del MonteTabor, Italy
Peptide-Based Vaccine Update

Wednesday, February 16 | 8:00AM - 11:15AM
Cancer Vaccines: Prophylaxy or Therapy
Room: Sweeney Ballroom C-E

Speaker 3 of 6
Vincent G. Brichard, GlaxoSmithKline Biologicals, Belgium
Development of the MAGE-A3 ASCI: From Tumor Specificity to Predictive Biomarkers

Wednesday, February 16 | 8:00AM - 11:15AM
Cancer Vaccines: Prophylaxy or Therapy
Room: Sweeney Ballroom C-E

Speaker 4 of 6
Tibor P. Keler, Celldex Therapeutics, Inc., USA
DC Targeting in Humans

Wednesday, February 16 | 8:00AM - 11:15AM
Cancer Vaccines: Prophylaxy or Therapy
Room: Sweeney Ballroom C-E

Speaker 5 of 6
Asís Palazón, CIMA, Spain
Short Talk: Agonist Anti-CD137 mAb Act on Tumor Endothelial Cells to Enhance Recruitment of Activated T Lymphocytes

Wednesday, February 16 | 8:00AM - 11:15AM
Cancer Vaccines: Prophylaxy or Therapy
Room: Sweeney Ballroom C-E

Speaker 6 of 6
Lotte Pyfferoen, Ghent University, Belgium
Short Talk: Multilevel Immunomodulation in an Orthotopic Mouse Model of Lung Cancer with Emphasis on Dendritic Cells

Wednesday, February 16 | 8:00AM - 11:15AM
Dendritic Cells in situ: Function and Biology
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 1 of 7
* Ira Mellman, Genentech, Inc., USA


Wednesday, February 16 | 8:00AM - 11:15AM
Dendritic Cells in situ: Function and Biology
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 2 of 7
Maria Rescigno, Humanitas University, Italy
DCs in Intestinal Disease and in Cancer Immunotherapy


Wednesday, February 16 | 8:00AM - 11:15AM
Dendritic Cells in situ: Function and Biology
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 3 of 7
Bart N. Lambrecht, VIB, Ghent University, Belgium
Airway Dendritic Cell Biology


Wednesday, February 16 | 8:00AM - 11:15AM
Dendritic Cells in situ: Function and Biology
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 4 of 7
Hiroshi Ohno, RIKEN Research Center for Allergy and Immunology, Japan
Short Talk: M Cells and Antigen Delivery to DCs in the Gut


Wednesday, February 16 | 8:00AM - 11:15AM
Dendritic Cells in situ: Function and Biology
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 5 of 7
Frederic Geissmann, Memorial Sloan Kettering Cancer Center, USA
Diseases of DCs in Humans


Wednesday, February 16 | 8:00AM - 11:15AM
Dendritic Cells in situ: Function and Biology
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 6 of 7
Shannon J. Turley, Genentech, Inc., USA
Regulation of DC Motility by Podoplanin Activation of Clec2


Wednesday, February 16 | 8:00AM - 11:15AM
Dendritic Cells in situ: Function and Biology
This session is from Dendritic Cells
Room: Sweeney Ballroom A-B

Speaker 7 of 7
Jun Lu, Brigham and Women's Hospital, USA
Short Talk: Dynamic Regulation of E-Cadherin on Myeloid DC Induces Ras and Potent T Cell Activation


Wednesday, February 16 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney F, Main Level Breakout Rooms


Wednesday, February 16 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, February 16 | 2:30PM - 4:30PM
Workshop 3: Perspectives on Breaking Tolerance in Cancer Imm
unotherapy
Room: Sweeney Ballroom C-E

Speaker 1 of 9
* Laurence Zitvogel, Institut Gustave Roussy, France

Wednesday, February 16 | 2:30PM - 4:30PM
Workshop 3: Perspectives on Breaking Tolerance in Cancer Imm
unotherapy
Room: Sweeney Ballroom C-E

Speaker 2 of 9
Alison Clare West, Peter MacCallum Cancer Centre, Australia
Anti-Cancer Therapy Mediated by a Histone Deacytelase Inhibitor Engages the Immune System

Wednesday, February 16 | 2:30PM - 4:30PM
Workshop 3: Perspectives on Breaking Tolerance in Cancer Imm
unotherapy
Room: Sweeney Ballroom C-E

Speaker 3 of 9
Saskia J.A.M. Santegoets, VU University Medical Center, Netherlands
The Induction of Autoantibodies to PSMA, PNPO and NRP2 Correlates with Clinical Outcome in Patients Treated with Prostate GVAX/Anti-CTLA-4 Immunotherapy

Wednesday, February 16 | 2:30PM - 4:30PM
Workshop 3: Perspectives on Breaking Tolerance in Cancer Imm
unotherapy
Room: Sweeney Ballroom C-E

Speaker 4 of 9
Anita Stam, VU University Medical Center, Netherlands
Increased Type-2/Th17 T Cell Rates are Associated with Favorable Clinical Outcome in Prostate Cancer Patients Treated with Prostate GVAX/anti-CTLA-4 Immunotherapy

Wednesday, February 16 | 2:30PM - 4:30PM
Workshop 3: Perspectives on Breaking Tolerance in Cancer Imm
unotherapy
Room: Sweeney Ballroom C-E

Speaker 5 of 9
Jose A. Villadangos, University of Melbourne, Australia
Antigen Presentation by Tumor Cells, not by DC nor GR1+CD11b+ Cells, Rapidly Impairs Adoptive Anti-Lymphoma CTL Therapy

Wednesday, February 16 | 2:30PM - 4:30PM
Workshop 3: Perspectives on Breaking Tolerance in Cancer Imm
unotherapy
Room: Sweeney Ballroom C-E

Speaker 6 of 9
Rikke Sick Andersen, University of Southern Denmark, Denmark
T-Cell Specificities of Tumor-Infiltrating Lymphocytes from Patients with Malignant Melanoma

Wednesday, February 16 | 2:30PM - 4:30PM
Workshop 3: Perspectives on Breaking Tolerance in Cancer Imm
unotherapy
Room: Sweeney Ballroom C-E

Speaker 7 of 9
Alexandre Johannsen, CHUV, Switzerland
Definition of Key Variables for the Induction of Optimal NY-ESO-1-Specific T Cells in HLA Transgene Mice

Wednesday, February 16 | 2:30PM - 4:30PM
Workshop 3: Perspectives on Breaking Tolerance in Cancer Imm
unotherapy
Room: Sweeney Ballroom C-E

Speaker 8 of 9
Toby Lawrence, INSERM, France
IkappaB Kinase (IKK)beta Activation in Macrophages Maintains Tumor-Induced Immune Tolerance

Wednesday, February 16 | 2:30PM - 4:30PM
Workshop 3: Perspectives on Breaking Tolerance in Cancer Imm
unotherapy
Room: Sweeney Ballroom C-E

Speaker 9 of 9
Monique H. M. Melis, Netherlands Cancer Institute, Netherlands
Development of a Doxycycline-Dependent Caspase 3 Death Switch Model to Assess the Host Immune Response to Rapid and Synchronous Tumor Cell Apoptosis in vivo

Wednesday, February 16 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney F, Main Level Breakout Rooms


Wednesday, February 16 | 5:00PM - 7:00PM
Translating Immune Responses Toward and Into the Clinic (Joi
nt)

Room: Sweeney Ballroom A-E

Speaker 1 of 4
* Virginia Pascual, Cornell University, USA

Wednesday, February 16 | 5:00PM - 7:00PM
Translating Immune Responses Toward and Into the Clinic (Joi
nt)

Room: Sweeney Ballroom A-E

Speaker 2 of 4
Robert A. Seder, NIAID, National Institutes of Health, USA
TLRs in Vaccine Development

Wednesday, February 16 | 5:00PM - 7:00PM
Translating Immune Responses Toward and Into the Clinic (Joi
nt)

Room: Sweeney Ballroom A-E

Speaker 3 of 4
Gerold Schuler, University Hospital of Erlangen, Germany
Monocyte-Derived Dendritic Cells in Cancer Immunotherapy

Wednesday, February 16 | 5:00PM - 7:00PM
Translating Immune Responses Toward and Into the Clinic (Joi
nt)

Room: Sweeney Ballroom A-E

Speaker 4 of 4
Lei Zheng, Johns Hopkins University School of Medicine, USA
Regulatory T Cells and their Role in the Tumor Micro-Environment

Wednesday, February 16 | 7:00PM - 8:00PM
Closing Keynote Address (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 2
* Ira Mellman, Genentech, Inc., USA

Wednesday, February 16 | 7:00PM - 8:00PM
Closing Keynote Address (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 2
Ralph M. Steinman, Rockefeller University, USA
In vivo Veritas in Humans

Wednesday, February 16 | 8:00PM - 9:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakout Rooms


Wednesday, February 16 | 8:00PM - 11:00PM
Entertainment
Room: Sweeney F, Main Level Breakout Rooms


Wednesday, February 16 | 8:00PM - 11:00PM
Cash Bar
Room: Sweeney F, Main Level Breakout Rooms


Thursday, February 17 | 10:25AM - 10:25AM
Departure


*Session Chair.