Web Desc
Immunological Mechanisms of Vaccination
Organizer(s): Bali Pulendran, Rino Rappuoli and Bruce A. Beutler
Date: October 27 - November 01, 2010
Location: Sheraton Seattle Hotel, Seattle, WA, USA
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
Vaccines have been described as one of the most cost effective public health tools in history. Despite their success, most vaccines have been made empirically, and we understand little about the mechanisms by which they stimulate protective immunity. Indeed, immunologists and vaccinologists have until recently, occupied parallel universes! Understanding the immunology of vaccines and infections is of paramount importance in the rational design of future vaccines against pandemics such as HIV, malaria and tuberculosis, and against emerging infections such as swine influenza and dengue. Recent advances in immunology, human genetics, and systems biology are beginning to offer a deeper understanding of the molecular and cellular mechanisms of host immunity, and the pivotal role played by the innate immune system in shaping the adaptive immune response. Such insights are enhancing our understanding of the correlates of protective immunities, of the early innate immune signatures of vaccine efficacy, and guiding the rational design of novel and safer vaccines and adjuvants. Immunological Mechanisms of Vaccination will bring together an interdisciplinary group of scientists in immunology, virology, systems biology and vaccinology, to address critical advances in these fields and their implications for vaccinology. • The importance of the innate immune system in sensing vaccines and shaping the vaccine immunity • Modulating immune memory to vaccines with innate immunity • Novel approaches to understanding host-pathogen interactions • Deconstructing the mode of action of successful vaccines, vectors adjuvants with innate immunity • Constructing new vaccines and adjuvants with innate immunity • Application of systems biology to predicting vaccine efficacy, and discovering novel immune mechanisms of protection
Global Health Travel Award Deadline: June 1 2010
Scholarship Deadline: June 28 2010
Discounted Abstract Deadline: June 28 2010
Abstract Deadline: July 30 2010
Discounted Registration Deadline: August 27 2010
We gratefully acknowledge additional support for this conference from:
Bill & Melinda Gates FoundationLandes Bioscience
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

CSL Limited

Dynavax Technologies Corporation

GlaxoSmithKline Biologicals

Novartis Vaccines and Diagnostics
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI091178-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, October 27 | 1:00PM - 5:00PM
Registration
Room: Grand Ballroom Foyer


Wednesday, October 27 | 5:00PM - 5:30PM
Coffee Available, Joint with GCGH
Room: Grand Ballroom Foyer


Wednesday, October 27 | 5:30PM - 7:00PM
Keynote Session (Joint Session with Grand Challenges in Glob
al Health)
Room: Grand Ballroom C-D

Speaker 1 of 3
* Chris Wilson, Bill & Melinda Gates Foundation, USA

Wednesday, October 27 | 5:30PM - 7:00PM
Keynote Session (Joint Session with Grand Challenges in Glob
al Health)
Room: Grand Ballroom C-D

Speaker 2 of 3
Tadataka Yamada, Mountain Field LLC, USA
Innovation in Vaccine Research for Global Health

Wednesday, October 27 | 5:30PM - 7:00PM
Keynote Session (Joint Session with Grand Challenges in Glob
al Health)
Room: Grand Ballroom C-D

Speaker 3 of 3
Anthony S. Fauci, NIAID, National Institutes of Health, USA
Challenges in Vaccinology: A Tale of Three Diseases

Wednesday, October 27 | 7:00PM - 9:00PM
Joint Reception with GCGH
Room: Sweeney F, Main Level Breakout Rooms


Thursday, October 28 | 7:30AM - 8:30AM
Breakfast
Room: Sweeney F, Main Level Breakout Rooms


Thursday, October 28 | 8:30AM - 9:00AM
Orientation
Room: Grand Ballroom C-D


Thursday, October 28 | 9:00AM - 12:45PM
Innate Sensing of Pathogens and Vaccines
Room: Grand Ballroom C/D

Speaker 1 of 6
Bruce A. Beutler, University of Texas Southwestern Medical Center, USA
Dissecting Innate Sensing with Forward Genetics

Thursday, October 28 | 9:00AM - 12:45PM
Innate Sensing of Pathogens and Vaccines
Room: Grand Ballroom C/D

Speaker 2 of 6
* Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Mechanisms Underlying the Sensing of Microbial DNA

Thursday, October 28 | 9:00AM - 12:45PM
Innate Sensing of Pathogens and Vaccines
Room: Grand Ballroom C/D

Speaker 3 of 6
Dana Philpott, University of Toronto, Canada
Innate Sensing of Microbes by NOD Proteins

Thursday, October 28 | 9:00AM - 12:45PM
Innate Sensing of Pathogens and Vaccines
Room: Grand Ballroom C/D

Speaker 4 of 6
Philippa C. Marrack, HHMI/National Jewish Health, USA
The Adjuvant and Other Activities of Alum

Thursday, October 28 | 9:00AM - 12:45PM
Innate Sensing of Pathogens and Vaccines
Room: Grand Ballroom C/D

Speaker 5 of 6
Stephanie C. Eisenbarth, Yale University, USA
Short Talk: The Nlrp3 Inflammasome Regulates Th17 but not Th2 Differentiation Following Immunization

Thursday, October 28 | 9:00AM - 12:45PM
Innate Sensing of Pathogens and Vaccines
Room: Grand Ballroom C/D

Speaker 6 of 6
* Ken J. Ishii, National Institute of Biomedical Innovation, Health and Nutrition, Japan
Short Talk: Innate Immune Signaling Pathways Essential for DNA and Viral Vaccines

Thursday, October 28 | 9:40AM - 10:00AM
Coffee Break
Room: Grand Ballroom Foyer


Thursday, October 28 | 12:45PM - 1:00PM
Poster Setup
Room: Sweeney F, Main Level Breakout Rooms


Thursday, October 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakout Rooms


Thursday, October 28 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Thursday, October 28 | 5:00PM - 7:00PM
Understanding T and B Cell Memory to Vaccines
Room: Grand Ballroom C/D

Speaker 1 of 5
* Ronald N. Germain, NIAID, National Institutes of Health, USA

Thursday, October 28 | 5:00PM - 7:00PM
Understanding T and B Cell Memory to Vaccines
Room: Grand Ballroom C/D

Speaker 2 of 5
Rafi Ahmed, Emory University School of Medicine, USA
Vaccination and Immune Memory

Thursday, October 28 | 5:00PM - 7:00PM
Understanding T and B Cell Memory to Vaccines
Room: Grand Ballroom C/D

Speaker 3 of 5
Shane Crotty, La Jolla Institute for Immunology, USA
Essential Roles of Follicular Helper CD4 T Cells (Tfh) in Antibody Responses to Vaccination

Thursday, October 28 | 5:00PM - 7:00PM
Understanding T and B Cell Memory to Vaccines
Room: Grand Ballroom C/D

Speaker 4 of 5
Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Dissecting the Human T and B Cell Response to Pathogens

Thursday, October 28 | 5:00PM - 7:00PM
Understanding T and B Cell Memory to Vaccines
Room: Grand Ballroom C/D

Speaker 5 of 5
Hana Golding, US Food and Drug Administration, USA
Short Talk: Shift in Antibody Repertoire and Greater Focus on Protective Epitopes in Hemagglutinin after Vaccination with Oil-in-water Adjuvanted Pandemic Influenza Vaccines

Thursday, October 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakout Rooms


Thursday, October 28 | 7:30PM - 10:00PM
Poster Session 1
Room: Sweeney F, Main Level Breakout Rooms


Friday, October 29 | 7:30AM - 8:30AM
Breakfast
Room: Sweeney F, Main Level Breakout Rooms


Friday, October 29 | 8:30AM - 11:45AM
Systems Biological Approaches to Vaccination and Infections
Room: Grand Ballroom C/D

Speaker 1 of 7
* Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany

Friday, October 29 | 8:30AM - 11:45AM
Systems Biological Approaches to Vaccination and Infections
Room: Grand Ballroom C/D

Speaker 2 of 7
Bali Pulendran, Stanford University School of Medicine, USA
Learning Immunology from Successful Vaccines: Innate Immunity to Systems Vaccinology

Friday, October 29 | 8:30AM - 11:45AM
Systems Biological Approaches to Vaccination and Infections
Room: Grand Ballroom C/D

Speaker 3 of 7
Ronald N. Germain, NIAID, National Institutes of Health, USA
A Systems Approach to Immunology

Friday, October 29 | 8:30AM - 11:45AM
Systems Biological Approaches to Vaccination and Infections
Room: Grand Ballroom C/D

Speaker 4 of 7
Alan Aderem, Center for Infectious Disease Research, USA
Systems Vaccinology: Using the Tools of Systems Biology to Enable Rational Vaccine Design

Friday, October 29 | 8:30AM - 11:45AM
Systems Biological Approaches to Vaccination and Infections
Room: Grand Ballroom C/D

Speaker 5 of 7
Rafick Sekaly, Emory University, USA
Systems Biology Approaches to Dissecting Protective Immune Responses

Friday, October 29 | 8:30AM - 11:45AM
Systems Biological Approaches to Vaccination and Infections
Room: Grand Ballroom C/D

Speaker 6 of 7
I-Ming Wang, Merck Research Lab, USA
Short Talk: Blood Profiling of Vaccines and Adjuvants in Non-Human Primates to Study Mode of Action, Immunogenicity and Predict Adverse Events

Friday, October 29 | 8:30AM - 11:45AM
Systems Biological Approaches to Vaccination and Infections
Room: Grand Ballroom C/D

Speaker 7 of 7
Surojit Sarkar, University of Washington School of Medicine, USA
Short Talk: Functional and Genomic Profiling of CD8 T Cell Memory Responses Elicited by Adenovirus 5 Vectored Immunogens

Friday, October 29 | 9:40AM - 10:00AM
Coffee Break
Room: Grand Ballroom Foyer


Friday, October 29 | 11:45AM - 1:00PM
Poster Setup
Room: Sweeney F, Main Level Breakout Rooms


Friday, October 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakout Rooms


Friday, October 29 | 2:30PM - 4:30PM
Workshop 1: Tuning the Immune Response
Room: Grand Ballroom C-D

Speaker 1 of 9
* Shane Crotty, La Jolla Institute for Immunology, USA

Friday, October 29 | 2:30PM - 4:30PM
Workshop 1: Tuning the Immune Response
Room: Grand Ballroom C-D

Speaker 2 of 9
Michael W. Munks, Oregon Health & Science University, USA
Aluminum Adjuvants Induce Fibrin-Dependent Extracellular Traps In Vivo

Friday, October 29 | 2:30PM - 4:30PM
Workshop 1: Tuning the Immune Response
Room: Grand Ballroom C-D

Speaker 3 of 9
Santhakumar Manicassamy, Emory University, USA
Activation of beta-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

Friday, October 29 | 2:30PM - 4:30PM
Workshop 1: Tuning the Immune Response
Room: Grand Ballroom C-D

Speaker 4 of 9
Carrie N. Arnold, Janssen, USA
Forward Genetic Analysis of the Humoral Immune Response

Friday, October 29 | 2:30PM - 4:30PM
Workshop 1: Tuning the Immune Response
Room: Grand Ballroom C-D

Speaker 5 of 9
Claudia Giesecke, Charité University Medicine Berlin, Germany
Secondary Immunization Generates Clonally Related Antigen-Specific Plasma Cells and Memory B Cells

Friday, October 29 | 2:30PM - 4:30PM
Workshop 1: Tuning the Immune Response
Room: Grand Ballroom C-D

Speaker 6 of 9
Yang Zhang, University of Birmingham, UK
Manipulating Affinity Maturation in the Germinal Centre

Friday, October 29 | 2:30PM - 4:30PM
Workshop 1: Tuning the Immune Response
Room: Grand Ballroom C-D

Speaker 7 of 9
Stefan Riebel, Max Planck Institute for Infection Biology, Germany
Single Cell Analysis of a Polyclonal Germinal Center Reaction

Friday, October 29 | 2:30PM - 4:30PM
Workshop 1: Tuning the Immune Response
Room: Grand Ballroom C-D

Speaker 8 of 9
Wendy G. H. Tan, Emory University, USA
Rapamycin Treatment Improves The Quality And Quantity Of Ad5 Vaccine Induced CD8 T Cell Responses

Friday, October 29 | 2:30PM - 4:30PM
Workshop 1: Tuning the Immune Response
Room: Grand Ballroom C-D

Speaker 9 of 9
Francis M. Ndungu, KEMRI, Wellcome Research Collaborative Programme, Kenya
Maintenance of Antibody and B Cell Memory to Plasmodium falciparum Antigens (in children) in the Absence of Persistent Exposure to Parasites

Friday, October 29 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Friday, October 29 | 5:00PM - 7:00PM
Novel Approaches to Understanding Host-Microbe Interactions
Room: Grand Ballroom C/D

Speaker 1 of 6
* Rafick Sekaly, Emory University, USA

Friday, October 29 | 5:00PM - 7:00PM
Novel Approaches to Understanding Host-Microbe Interactions
Room: Grand Ballroom C/D

Speaker 2 of 6
Lalita Ramakrishnan, University of Cambridge, UK
The Goldilocks Principle: Modulating Inflammation to Prevent and Treat Tuberculosis

Friday, October 29 | 5:00PM - 7:00PM
Novel Approaches to Understanding Host-Microbe Interactions
Room: Grand Ballroom C/D

Speaker 3 of 6
Daniel A. Portnoy, University of California, Berkeley, USA
Forward Microbial Genetics and the Discovery of cyclic-di-AMP: An Essential and Conserved Bacterial Signaling Molecule that Triggers the Type 1 Interferon Response

Friday, October 29 | 5:00PM - 7:00PM
Novel Approaches to Understanding Host-Microbe Interactions
Room: Grand Ballroom C/D

Speaker 4 of 6
Harlan Robins, Adaptive Biotechnologies, USA
Short Talk: Overlap and Effective Size of the Human CD8+ T-Cell Receptor Repertoir

Friday, October 29 | 5:00PM - 7:00PM
Novel Approaches to Understanding Host-Microbe Interactions
Room: Grand Ballroom C/D

Speaker 5 of 6
Eva Harris, Division of Infectious Diseases and Vaccinology, School of Public Health, USA
Short Talk: Investigating the Human Antibody and B Cell Repertoire in Dengue Virus Infection

Friday, October 29 | 5:00PM - 7:00PM
Novel Approaches to Understanding Host-Microbe Interactions
Room: Grand Ballroom C/D

Speaker 6 of 6
Sarah E. Henrickson, Children's Hospital of Philadelphia, USA
Short Talk: Low Dose, Short Duration Antigenic Constellation Fosters CD8+ T Cell Effector Function without Stable Contacts with DCs, Yielding Immunological Amnesia

Friday, October 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakout Rooms


Friday, October 29 | 7:30PM - 10:00PM
Poster Session 2
Room: Sweeney F, Main Level Breakout Rooms


Saturday, October 30 | 7:30AM - 8:30AM
Breakfast
Room: Sweeney F, Main Level Breakout Rooms


Saturday, October 30 | 8:30AM - 11:45AM
Translating Immunity to Vaccines
Room: Grand Ballroom C/D

Speaker 1 of 6
Ralph M. Steinman, Rockefeller University, USA
Dendritic Cell-Based Protein Vaccines Against AIDS

Saturday, October 30 | 8:30AM - 11:45AM
Translating Immunity to Vaccines
Room: Grand Ballroom C/D

Speaker 2 of 6
Christine Trumpfheller, Roche Glycart, Switzerland
Immunization of Rhesus Macaques with HIV Proteins and Adjuvant Followed by Recombinant NYVAC

Saturday, October 30 | 8:30AM - 11:45AM
Translating Immunity to Vaccines
Room: Grand Ballroom C/D

Speaker 3 of 6
* Robert L. Coffman, Dynavax Technologies, USA
Harnessing TLR9 Ligands for Immune Modulation

Saturday, October 30 | 8:30AM - 11:45AM
Translating Immunity to Vaccines
Room: Grand Ballroom C/D

Speaker 4 of 6
Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany
Immunology of TB: Impact on Vaccine Development

Saturday, October 30 | 8:30AM - 11:45AM
Translating Immunity to Vaccines
Room: Grand Ballroom C/D

Speaker 5 of 6
Sudhir Pai Kasturi, Emory University, USA
Short Talk: Programming the Quality and Persistence of Antibody Responses with Innate Immunity

Saturday, October 30 | 8:30AM - 11:45AM
Translating Immunity to Vaccines
Room: Grand Ballroom C/D

Speaker 6 of 6
Ofer Levy, Boston Children's Hospital, USA
Short Talk: Accounting for Innate Immune Ontogeny in Pre-Clinical Development of Pediatric Vaccines: Imidazoquinoline TLR8 Agonists Trigger Adenosine- & cAMP-Refractory Pathways for Robust Activation of Newborn and Infant Antigen-Presenting Cells

Saturday, October 30 | 9:40AM - 10:00AM
Coffee Break
Room: Grand Ballroom Foyer


Saturday, October 30 | 11:45AM - 1:00PM
Poster Setup
Room: Sweeney F, Main Level Breakout Rooms


Saturday, October 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakout Rooms


Saturday, October 30 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Saturday, October 30 | 5:00PM - 7:15PM
Immunity and Vaccines Against Pandemics and Emerging Pathoge
ns I

Room: Grand Ballroom C/D

Speaker 1 of 5
* Kanta Subbarao, WHO Collaborating Centre for Reference and Research on Influenza, Australia

Saturday, October 30 | 5:00PM - 7:15PM
Immunity and Vaccines Against Pandemics and Emerging Pathoge
ns I

Room: Grand Ballroom C/D

Speaker 2 of 5
Rino Rappuoli, GlaxoSmithKline Vaccines, Italy
Reverse Vaccinology

Saturday, October 30 | 5:00PM - 7:15PM
Immunity and Vaccines Against Pandemics and Emerging Pathoge
ns I

Room: Grand Ballroom C/D

Speaker 3 of 5
Joe D. Cohen, GlaxoSmithKline Biologicals, Belgium
The RTS/S Malaria Vaccine: Lessons Learned

Saturday, October 30 | 5:00PM - 7:15PM
Immunity and Vaccines Against Pandemics and Emerging Pathoge
ns I

Room: Grand Ballroom C/D

Speaker 4 of 5
M. Juliana McElrath, Fred Hutchinson Cancer Research Center, USA
Innate and Adaptive Immunity Against HIV Vaccines

Saturday, October 30 | 5:00PM - 7:15PM
Immunity and Vaccines Against Pandemics and Emerging Pathoge
ns I

Room: Grand Ballroom C/D

Speaker 5 of 5
Pia Dosenovic, Karolinska Institutet, Sweden
Short Talk: Manipulation of the Naïve B Cell Repertoire by Transient BLyS Treatment as a Means to Alter Vaccine-Elicited Ab Responses to HIV-1 Env

Saturday, October 30 | 7:15PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakout Rooms


Saturday, October 30 | 7:30PM - 10:00PM
Poster Session 3
Room: Sweeney F, Main Level Breakout Rooms


Sunday, October 31 | 7:30AM - 8:30AM
Breakfast
Room: Sweeney F, Main Level Breakout Rooms


Sunday, October 31 | 8:30AM - 11:45AM
Immunity and Vaccines Against Pandemics and Emerging Pathoge
ns II

Room: Grand Ballroom C/D

Speaker 1 of 7
* Patrick E. Duffy, NIAID, National Institutes for Health, USA

Sunday, October 31 | 8:30AM - 11:45AM
Immunity and Vaccines Against Pandemics and Emerging Pathoge
ns II

Room: Grand Ballroom C/D

Speaker 2 of 7
Stephen L. Hoffman, Sanaria, USA
Development of an Attenuated Sporozoite Vaccine to Prevent and Eliminate Plasmodium falciparum Malaria

Sunday, October 31 | 8:30AM - 11:45AM
Immunity and Vaccines Against Pandemics and Emerging Pathoge
ns II

Room: Grand Ballroom C/D

Speaker 3 of 7
Supachai Rerks-Ngarm, Prime-Boost HIV Vaccine Trial Phase III, Thailand
Phase III, Efficacy Trial of HIV Prime-Boost Vaccine Combination in Thailand: Immunological Studies and Future Plan

Sunday, October 31 | 8:30AM - 11:45AM
Immunity and Vaccines Against Pandemics and Emerging Pathoge
ns II

Room: Grand Ballroom C/D

Speaker 4 of 7
Kanta Subbarao, WHO Collaborating Centre for Reference and Research on Influenza, Australia
Scientific Obstacles to Developing Vaccines Against Pandemic Influenza

Sunday, October 31 | 8:30AM - 11:45AM
Immunity and Vaccines Against Pandemics and Emerging Pathoge
ns II

Room: Grand Ballroom C/D

Speaker 5 of 7
Firdausi Qadri, International Centre for Diarrhoeal Disease Research, Bangladesh
Immunity to Vibrio cholerae and Other Enteric Pathogens: Studies in Patients and Vaccines



Sunday, October 31 | 8:30AM - 11:45AM
Immunity and Vaccines Against Pandemics and Emerging Pathoge
ns II

Room: Grand Ballroom C/D

Speaker 6 of 7
Junbao Yang, Benaroya Research Institute, USA
Short Talk: The Dynamics of CD4+ T Cell Mediated Immunity to 2009 H1N1/Influenza A Virus

Sunday, October 31 | 8:30AM - 11:45AM
Immunity and Vaccines Against Pandemics and Emerging Pathoge
ns II

Room: Grand Ballroom C/D

Speaker 7 of 7
Bonnie B. Blomberg, University of Miami School of Medicine, USA
Short Talk: Intrinsic Defects in B Cell Response to both Seasonal Influenza and H1N1 Vaccination in Elderly Humans

Sunday, October 31 | 9:40AM - 10:00AM
Coffee Break
Room: Grand Ballroom Foyer


Sunday, October 31 | 1:30PM - 3:30PM
Workshop 2: Innate Control of Vaccine Immunity
Room: Grand Ballroom C-D

Speaker 1 of 8
* Cevayir Coban, Immunology Frontier Research Center, Osaka University, Japan

Sunday, October 31 | 1:30PM - 3:30PM
Workshop 2: Innate Control of Vaccine Immunity
Room: Grand Ballroom C-D

Speaker 2 of 8
Kevin Shenderov, NIAID, National Institutes of Health, USA
Inflammasome-dependent IL-1beta Production is Critical for Complete Freund’s Adjuvant-induced Helper T Cell Polarization

Sunday, October 31 | 1:30PM - 3:30PM
Workshop 2: Innate Control of Vaccine Immunity
Room: Grand Ballroom C-D

Speaker 3 of 8
Meghan E. Turnis, St. Jude Children's Research Hospital, USA
IRAK-M Removal Counteracts DC Vaccine Deficits in Migration and Longevity

Sunday, October 31 | 1:30PM - 3:30PM
Workshop 2: Innate Control of Vaccine Immunity
Room: Grand Ballroom C-D

Speaker 4 of 8
Ali H. Ellebedy, Washington University School of Medicine, USA
Critical Role for ASC in the Adjuvant Effect of MF59

Sunday, October 31 | 1:30PM - 3:30PM
Workshop 2: Innate Control of Vaccine Immunity
Room: Grand Ballroom C-D

Speaker 5 of 8
Arnaud Didierlaurent, University of Geneva, Switzerland
Link between Innate Responses and the Enhanced Adaptive Response: Insights into AS04 and AS03 Mechanism of Action

Sunday, October 31 | 1:30PM - 3:30PM
Workshop 2: Innate Control of Vaccine Immunity
Room: Grand Ballroom C-D

Speaker 6 of 8
Anke Huckriede, Netherlands
Vaccine-Triggered Innate Reactions of Dendritic Cells Correlate with the Immune Response Evoked by Vaccination

Sunday, October 31 | 1:30PM - 3:30PM
Workshop 2: Innate Control of Vaccine Immunity
Room: Grand Ballroom C-D

Speaker 7 of 8
Elena Caproni, Novartis Vaccines & Diagnostics, Italy
Distinctive Innate Immune Signatures at Injection Site Boost the Adaptive Response to Flu Subunit Vaccine

Sunday, October 31 | 1:30PM - 3:30PM
Workshop 2: Innate Control of Vaccine Immunity
Room: Grand Ballroom C-D

Speaker 8 of 8
Susanna R. Brauner, Karolinska Institutet, Sweden
Vaccination of Patients with the Autoimmune Disease Sjögren’s Syndrome Induces IL-7 and Skewed B Cell Maturation with Increased Levels of Plasmablasts Resulting in Higher Titers of Vaccine-Specific IgG Antibodies

Sunday, October 31 | 3:30PM - 4:00PM
Coffee Available
Room: Grand Foyer


Sunday, October 31 | 4:00PM - 6:00PM
Immunology of Adjuvants
Room: Grand Ballroom C/D

Speaker 1 of 5
* Hana Golding, US Food and Drug Administration, USA

Sunday, October 31 | 4:00PM - 6:00PM
Immunology of Adjuvants
Room: Grand Ballroom C/D

Speaker 2 of 5
Ennio De Gregorio, GlaxoSmithKline Vaccines, Italy
Molecular and Cellular Signatures of Vaccine Adjuvants

Sunday, October 31 | 4:00PM - 6:00PM
Immunology of Adjuvants
Room: Grand Ballroom C/D

Speaker 3 of 5
Steven Reed, Infectious Disease Research Institute, USA
Rational Design of New Adjuvants

Sunday, October 31 | 4:00PM - 6:00PM
Immunology of Adjuvants
Room: Grand Ballroom C/D

Speaker 4 of 5
Eugene Maraskovsky, CSL Limited, Australia
Short Talk: Mechanisms of Action of ISCOMATRIX® adjuvant

Sunday, October 31 | 4:00PM - 6:00PM
Immunology of Adjuvants
Room: Grand Ballroom C/D

Speaker 5 of 5
Norman Baylor, Biologics Consulting Group, Inc., USA
Adjuvant Development: The View from the FDA

Sunday, October 31 | 6:00PM - 7:00PM
Concluding Remarks
Room: Grand Ballroom C-D

Speaker 1 of 1
Peter C. Doherty, University of Melbourne, Australia

Sunday, October 31 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakout Rooms


Sunday, October 31 | 8:00PM - 11:00PM
Cash Bar
Room: Sweeney F, Main Level Breakout Rooms


Sunday, October 31 | 8:00PM - 11:00PM
Entertainment
Room: Sweeney F, Main Level Breakout Rooms


Monday, November 01 | 10:25AM - 10:25AM
Departure


*Session Chair.