Web Desc
PI 3-Kinase Signaling Pathways
joint with Inositide Signaling in Pharmacology and Disease
Organizer(s): Bart Vanhaesebroeck, Sabina Cosulich and Ramon Parsons
Date: February 13 - 18, 2011
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Bayer USA Foundation and Genentech, Inc.
Summary of Meeting:
The PI 3-kinase signaling pathway controls multiple physiological processes including cell growth, cell proliferation and cell movement. Dysregulation of this pathway in cancer, inflammation and heart disease has led to the emergence of PI 3-kinase as a promising therapeutic target. One of the most exciting developments in this field is the development of new PI 3-kinase inhibitors that are currently entering the clinic. The balance between modulating PI 3-kinase activity in a pathophysiological setting, while avoiding unwanted side effects, is the subject of intense debate. In addition, as PI 3-kinase is a member of a multigene family, the rationale for inhibiting individual isoforms or multiple isoforms of PI 3-kinase is constantly changing. This meeting aims to bring together scientists and clinicians from academia and industry to discuss the opportunities and liabilities of targeting the PI 3-kinase pathway in disease, drawing on human pathophysiology and genetics, mouse models and (pre)clinical data with new PI 3-kinase inhibitors.
Scholarship Deadline: October 14 2010
Discounted Abstract Deadline: October 14 2010
Abstract Deadline: November 18 2010
Discounted Registration Deadline: December 14 2010
We gratefully acknowledge additional support for this conference from:
Bayer USA FoundationCell Signaling Technology, Inc.
Genentech, Inc.
Intellikine, Inc.Santa Cruz Biotechnology, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

AstraZeneca

Calistoga Pharmaceuticals, Inc.

Genentech, Inc.

Sanofi US
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Portland Press Ltd
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK084688-02
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 13 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Sunday, February 13 | 6:15PM - 7:15PM
Refreshments
Room: Longs Peak Foyer


Sunday, February 13 | 7:15PM - 7:30PM
Welcome Address (Joint, on behalf of both meetings)
Room: Longs/Grays Peak

Speaker 1 of 1
* Sabina C. Cosulich, AstraZeneca Oncology, UK

Sunday, February 13 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Longs/Grays Peak

Speaker 1 of 3
* Robin F. Irvine, University of Cambridge, UK

Sunday, February 13 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Longs/Grays Peak

Speaker 2 of 3
Robert H. Michell, University of Birmingham, UK
Inositol Phospholipids: Origins and Evolution of Functions

Sunday, February 13 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Longs/Grays Peak

Speaker 3 of 3
Lewis C. Cantley, Weill Cornell Medicine, USA
The Role of Phosphoinositides in Human Disease

Monday, February 14 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Monday, February 14 | 8:00AM - 11:15AM
Phosphoinositide 3-Kinase Signaling in Disease: Class 1 PI3K
s (Joint)

Room: Longs/Grays Peak

Speaker 1 of 8
* Marco Falasca, Curtin University, Australia

Monday, February 14 | 8:00AM - 11:15AM
Phosphoinositide 3-Kinase Signaling in Disease: Class 1 PI3K
s (Joint)

Room: Longs/Grays Peak

Speaker 2 of 8
* David A. Fruman, University of California, Irvine, USA

Monday, February 14 | 8:00AM - 11:15AM
Phosphoinositide 3-Kinase Signaling in Disease: Class 1 PI3K
s (Joint)

Room: Longs/Grays Peak

Speaker 3 of 8
Bart Vanhaesebroeck, University College London, Cancer Institute, UK
Direct and Indirect Actions of PI3K in Cancer

Monday, February 14 | 8:00AM - 11:15AM
Phosphoinositide 3-Kinase Signaling in Disease: Class 1 PI3K
s (Joint)

Room: Longs/Grays Peak

Speaker 4 of 8
Roger L. Williams, Medical Research Council, UK
Structural Insights into PI3K Isoform-Specific Signaling

Monday, February 14 | 8:00AM - 11:15AM
Phosphoinositide 3-Kinase Signaling in Disease: Class 1 PI3K
s (Joint)

Room: Longs/Grays Peak

Speaker 5 of 8
Len R. Stephens, Babraham Institute, UK
Mass Spectrometry based Measurement of PtdIns(3,4,5)P3 Molecular Species

Monday, February 14 | 8:00AM - 11:15AM
Phosphoinositide 3-Kinase Signaling in Disease: Class 1 PI3K
s (Joint)

Room: Longs/Grays Peak

Speaker 6 of 8
Ana Clara Carrera, Centro Nacional Biotechnologia/CSIC, Spain
PI3K Isoforms Function in Inflammation and Cancer

Monday, February 14 | 8:00AM - 11:15AM
Phosphoinositide 3-Kinase Signaling in Disease: Class 1 PI3K
s (Joint)

Room: Longs/Grays Peak

Speaker 7 of 8
Katarina Ejeskär, Probion Innovation Sweden, Sweden
Short Talk: p37delta, a New Isoform of PI3K p110delta, Increases Cell Proliferation in vitro and in vivo

Monday, February 14 | 8:00AM - 11:15AM
Phosphoinositide 3-Kinase Signaling in Disease: Class 1 PI3K
s (Joint)

Room: Longs/Grays Peak

Speaker 8 of 8
Deborah H. Anderson, Saskatchewan Cancer Agency, Canada
Short Talk: Regulation of PTEN by the p85 Subunit of Phosphatidylinositol 3-Kinase (PI3K)

Monday, February 14 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, February 14 | 11:15AM - 1:00PM
Poster Setup
Room: Quandary Peak


Monday, February 14 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, February 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary Peak


Monday, February 14 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, February 14 | 5:00PM - 7:00PM
PI 3-Kinase and Signaling: Non-Class I PI3Ks
Room: Longs Peak

Speaker 1 of 6
* Bart Vanhaesebroeck, University College London, Cancer Institute, UK

Monday, February 14 | 5:00PM - 7:00PM
PI 3-Kinase and Signaling: Non-Class I PI3Ks
Room: Longs Peak

Speaker 2 of 6
Takehiko Sasaki, Tokyo Medical and Dental University, Japan
Role for 3-Phosphoinositide Metabolism in vivo

Monday, February 14 | 5:00PM - 7:00PM
PI 3-Kinase and Signaling: Non-Class I PI3Ks
Room: Longs Peak

Speaker 3 of 6
Jonathan M. Backer, Albert Einstein College of Medicine, USA
Regulation of Class I and Class III PI 3-Kinases

Monday, February 14 | 5:00PM - 7:00PM
PI 3-Kinase and Signaling: Non-Class I PI3Ks
Room: Longs Peak

Speaker 4 of 6
David Harris, Lexicon Pharmaceuticals, Inc., USA
Short Talk: Requirement for the Class II Phosphoinositide 3-Kinase C2alpha in Maintenance of Glomerular Structure and Function

Monday, February 14 | 5:00PM - 7:00PM
PI 3-Kinase and Signaling: Non-Class I PI3Ks
Room: Longs Peak

Speaker 5 of 6
Tania Maffucci, Queen Mary University of London, UK
Short Talk: Role of Class II Phosphoinositide 3-Kinase alpha in Diabetes

Monday, February 14 | 5:00PM - 7:00PM
PI 3-Kinase and Signaling: Non-Class I PI3Ks
Room: Longs Peak

Speaker 6 of 6
Frederic A. Meunier, Queensland Brain Institute, Australia
Short Talk: Fine-Tuning of Neuroexocytosis by Two Members of the PI3-Kinase Family: Type I PI3Kdelta and Type II PI3K-C2alpha

Monday, February 14 | 5:00PM - 7:00PM
Other Phosphoinositide Kinases
This session is from Inositide Signaling
Room: Grays Peak

Speaker 1 of 5
* Pietro V. De Camilli, Yale University School of Medicine, USA


Monday, February 14 | 5:00PM - 7:00PM
Other Phosphoinositide Kinases
This session is from Inositide Signaling
Room: Grays Peak

Speaker 2 of 5
Nullin Divecha, University of Southampton, UK
PIP2 Synthesis


Monday, February 14 | 5:00PM - 7:00PM
Other Phosphoinositide Kinases
This session is from Inositide Signaling
Room: Grays Peak

Speaker 3 of 5
Robin F. Irvine, University of Cambridge, UK
Inositide Kinases and their Products - A Matter of Location


Monday, February 14 | 5:00PM - 7:00PM
Other Phosphoinositide Kinases
This session is from Inositide Signaling
Room: Grays Peak

Speaker 4 of 5
Scott D. Emr, Cornell University, USA
Phosphoinositide Signaling and Membrane Traffic: Regulation of PIP
Phosphatases


Monday, February 14 | 5:00PM - 7:00PM
Other Phosphoinositide Kinases
This session is from Inositide Signaling
Room: Grays Peak

Speaker 5 of 5
Assia Shisheva, Wayne State University School of Medicine, USA
Short Talk: PIKfyve-ArPIKfyve-Sac3 Protein Machinery to Orchestrate Coordinated Regulation of PI(3,5)P2 Synthesis and Turnover in Mammalian Cells


Monday, February 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary Peak


Monday, February 14 | 7:30PM - 10:00PM
Poster Session 1
Room: Quandary Peak


Tuesday, February 15 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Tuesday, February 15 | 8:00AM - 11:15AM
Downstream of PI 3-Kinase: Akt, mTOR and Metabolism
Room: Longs Peak

Speaker 1 of 7
* Neal Rosen, Memorial Sloan-Kettering Cancer Center, USA

Tuesday, February 15 | 8:00AM - 11:15AM
Downstream of PI 3-Kinase: Akt, mTOR and Metabolism
Room: Longs Peak

Speaker 2 of 7
Alex Toker, Beth Israel Deaconess Medical Center, USA
Akt Isoform Specificity in Breast Cancer Cell Signaling

Tuesday, February 15 | 8:00AM - 11:15AM
Downstream of PI 3-Kinase: Akt, mTOR and Metabolism
Room: Longs Peak

Speaker 3 of 7
Brendan D. Manning, Harvard School of Public Health, USA
mTOR Controls Cellular Metabolism Downstream of PI3K

Tuesday, February 15 | 8:00AM - 11:15AM
Downstream of PI 3-Kinase: Akt, mTOR and Metabolism
Room: Longs Peak

Speaker 4 of 7
Joan S. Brugge, Harvard Medical School, USA
PI3K Pathway in Tumor Cell Metabolism and Matrix Control

Tuesday, February 15 | 8:00AM - 11:15AM
Downstream of PI 3-Kinase: Akt, mTOR and Metabolism
Room: Longs Peak

Speaker 5 of 7
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Activation of the PI3K Pathway is Essential for Cell Autonomous Nutrient Uptake

Tuesday, February 15 | 8:00AM - 11:15AM
Downstream of PI 3-Kinase: Akt, mTOR and Metabolism
Room: Longs Peak

Speaker 6 of 7
James Brugarolas, UT Southwestern Medical Center, USA
Short Talk: Regulation of V-ATPases and Endocytosis by mTORC1

Tuesday, February 15 | 8:00AM - 11:15AM
Downstream of PI 3-Kinase: Akt, mTOR and Metabolism
Room: Longs Peak

Speaker 7 of 7
David A. Fruman, University of California, Irvine, USA
Short Talk: TOR Inhibitors Promote Activity of FOXO Transcription Factors in Lymphocytes

Tuesday, February 15 | 8:00AM - 11:15AM
Phosphoinositides in Signaling and Disease
This session is from Inositide Signaling
Room: Grays Peak

Speaker 1 of 7
* Scott D. Emr, Cornell University, USA


Tuesday, February 15 | 8:00AM - 11:15AM
Phosphoinositides in Signaling and Disease
This session is from Inositide Signaling
Room: Grays Peak

Speaker 2 of 7
Vojo Deretic, University of New Mexico Health Sciences Center, USA
Autophagy: Good or Bad in Cancer


Tuesday, February 15 | 8:00AM - 11:15AM
Phosphoinositides in Signaling and Disease
This session is from Inositide Signaling
Room: Grays Peak

Speaker 3 of 7
Bernard Payrastre, INSERM, France
Phosphoinositide Signaling and Diseases: A Role for PtdIns5P


Tuesday, February 15 | 8:00AM - 11:15AM
Phosphoinositides in Signaling and Disease
This session is from Inositide Signaling
Room: Grays Peak

Speaker 4 of 7
Peter J. Cullen, University of Bristol, UK
Phosphoinositides and the Regulation of the Endo-Lysosomal Network


Tuesday, February 15 | 8:00AM - 11:15AM
Phosphoinositides in Signaling and Disease
This session is from Inositide Signaling
Room: Grays Peak

Speaker 5 of 7
Tamas Balla, NICHD, National Institutes of Health, USA
Detection and Rapid Manipulation of Phosphoinositides in Living Cells


Tuesday, February 15 | 8:00AM - 11:15AM
Phosphoinositides in Signaling and Disease
This session is from Inositide Signaling
Room: Grays Peak

Speaker 6 of 7
Amy Kiger, University of California, San Diego, USA
Short Talk: Coordinated PI3KC2/Mtm Phosphoinositide Regulation and Rab activity in Membrane Trafficking and Disease


Tuesday, February 15 | 8:00AM - 11:15AM
Phosphoinositides in Signaling and Disease
This session is from Inositide Signaling
Room: Grays Peak

Speaker 7 of 7
Xinjiang Cai, Skirball Institute of Biomolecular Medicine, NYU Medical Center, USA
Short Talk: Negative Regulation of CD4 T Cell Activation by Tripartite Motif Containing Protein 27 via the Ubiquitination and Inhibition of the Class II Phosphatidylinositol 3 Kinase C2-beta


Tuesday, February 15 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, February 15 | 11:15AM - 1:00PM
Poster Setup
Room: Quandary Peak


Tuesday, February 15 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, February 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary Peak


Tuesday, February 15 | 2:30PM - 4:30PM
Workshop: Novel Experimental Approaches to Investigate Phosp
hoinositide Signalling
This session is from Inositide Signaling
Room: Grays Peak

Speaker 1 of 9
* Tamas Balla, NICHD, National Institutes of Health, USA


Tuesday, February 15 | 2:30PM - 4:30PM
Workshop: Novel Experimental Approaches to Investigate Phosp
hoinositide Signalling
This session is from Inositide Signaling
Room: Grays Peak

Speaker 2 of 9
Thomas Masters, Mechanobiology Institute, Singapore
Evidence for a Fence that Impedes the Diffusion of Phosphatidylinositol 4,5-Bisphosphate (PIP2) Out of the Forming Phagosomes of Macrophages


Tuesday, February 15 | 2:30PM - 4:30PM
Workshop: Novel Experimental Approaches to Investigate Phosp
hoinositide Signalling
This session is from Inositide Signaling
Room: Grays Peak

Speaker 3 of 9
Dominik Oliver, University of Marburg, Germany
Voltage Sensitive Phosphatases as Tools for Characterizing Phosphoinositide Sensors and Effectors


Tuesday, February 15 | 2:30PM - 4:30PM
Workshop: Novel Experimental Approaches to Investigate Phosp
hoinositide Signalling
This session is from Inositide Signaling
Room: Grays Peak

Speaker 4 of 9
Qisheng Zhang, University of North Carolina at Chapel Hill, USA
Small Molecule Reporters and Modulators for Mammalian Phospholipase C Isozymes


Tuesday, February 15 | 2:30PM - 4:30PM
Workshop: Novel Experimental Approaches to Investigate Phosp
hoinositide Signalling
This session is from Inositide Signaling
Room: Grays Peak

Speaker 5 of 9
Wonhwa Cho, University of Illinois at Chicago, USA
In Situ Quantitative Imaging of Phosphoinositides


Tuesday, February 15 | 2:30PM - 4:30PM
Workshop: Novel Experimental Approaches to Investigate Phosp
hoinositide Signalling
This session is from Inositide Signaling
Room: Grays Peak

Speaker 6 of 9
Gerry Hammond, University of Cambridge, UK
Dissecting the Roles of Plasma Membrane PtdIns4P and PtdIns(4,5)P2


Tuesday, February 15 | 2:30PM - 4:30PM
Workshop: Novel Experimental Approaches to Investigate Phosp
hoinositide Signalling
This session is from Inositide Signaling
Room: Grays Peak

Speaker 7 of 9
Lucia E. Rameh, Boston Biomedical Research Institute, USA
A New Mechanism for Regulating the PI-5-P Pathway for PI-4,5-P2 Synthesis in Response to Changes in the Extracellular Environment


Tuesday, February 15 | 2:30PM - 4:30PM
Workshop: Novel Experimental Approaches to Investigate Phosp
hoinositide Signalling
This session is from Inositide Signaling
Room: Grays Peak

Speaker 8 of 9
Jeffrey R. Peterson, Fox Chase Cancer Center, USA
Phosphoinositides are Essential Co-Activators for p21-Activated Kinase 1 (Pak1)


Tuesday, February 15 | 2:30PM - 4:30PM
Workshop: Novel Experimental Approaches to Investigate Phosp
hoinositide Signalling
This session is from Inositide Signaling
Room: Grays Peak

Speaker 9 of 9
Michael J. Schell, Uniformed Services University, USA
F-Actin Binding by Inositol Trisphosphate 3-Kinase: A Recent Evolutionary Elaboration for Localized IP3 Control and Structural Plasticity in Dendritic Spines


Tuesday, February 15 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, February 15 | 5:00PM - 7:00PM
Therapeutic Strategies in the PI 3-Kinase Pathway
Room: Longs Peak

Speaker 1 of 5
* Sabina C. Cosulich, AstraZeneca Oncology, UK

Tuesday, February 15 | 5:00PM - 7:00PM
Therapeutic Strategies in the PI 3-Kinase Pathway
Room: Longs Peak

Speaker 2 of 5
Christian Rommel, F. Hoffmann-La Roche Ltd, Switzerland
Targeting PI3Kalpha and TORC1/2 Alone or in Combination for the Treatment of Solid Tumor

Tuesday, February 15 | 5:00PM - 7:00PM
Therapeutic Strategies in the PI 3-Kinase Pathway
Room: Longs Peak

Speaker 3 of 5
Neal Rosen, Memorial Sloan-Kettering Cancer Center, USA
PI3K Pathways in Cancer, Mechanistic Insights

Tuesday, February 15 | 5:00PM - 7:00PM
Therapeutic Strategies in the PI 3-Kinase Pathway
Room: Longs Peak

Speaker 4 of 5
Jeffrey A. Engelman, Novartis Institutes for BioMedical Research, USA
Optimizing PI3K Targeting in Cancer, Mechanistic Insights

Tuesday, February 15 | 5:00PM - 7:00PM
Therapeutic Strategies in the PI 3-Kinase Pathway
Room: Longs Peak

Speaker 5 of 5
Kyle A. Edgar, Genentech, Inc., USA
Short Talk: PI3K Pathway Signaling Promotes an Invasive Phenotype that is Independent of Akt

Tuesday, February 15 | 5:00PM - 7:00PM
Phosphoinositide Metabolism
This session is from Inositide Signaling
Room: Grays Peak

Speaker 1 of 5
* Nullin Divecha, University of Southampton, UK


Tuesday, February 15 | 5:00PM - 7:00PM
Phosphoinositide Metabolism
This session is from Inositide Signaling
Room: Grays Peak

Speaker 2 of 5
Pietro V. De Camilli, Yale University School of Medicine, USA
Phosphoinositide Metabolism in Endocytic Membrane Traffic


Tuesday, February 15 | 5:00PM - 7:00PM
Phosphoinositide Metabolism
This session is from Inositide Signaling
Room: Grays Peak

Speaker 3 of 5
Shamshad Cockcroft, University College London, UK
Phosphatidylinositol Transfer Proteins: Is Phosphatidylinositol Transfer or Binding the Key to Function Phosphatidylinositol Transfer Proteins: Is Phosphatidylinositol Transfer Activity Required for Function?


Tuesday, February 15 | 5:00PM - 7:00PM
Phosphoinositide Metabolism
This session is from Inositide Signaling
Room: Grays Peak

Speaker 4 of 5
Lois S. Weisman, University of Michigan, USA
Roles of Phosphatidylinositol 3,5 bis Phosphate, a Lipid with Unexpected Links to Neurodegenerative Disease


Tuesday, February 15 | 5:00PM - 7:00PM
Phosphoinositide Metabolism
This session is from Inositide Signaling
Room: Grays Peak

Speaker 5 of 5
Dave Bridges, University of Michigan, USA
Short Talk: Endolysosomal Phosphatidylinositides and the Regulation of TORC1 Localization and Function


Tuesday, February 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary Peak


Tuesday, February 15 | 7:30PM - 10:00PM
Poster Session 2
Room: Quandary Peak


Wednesday, February 16 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Wednesday, February 16 | 8:00AM - 11:15AM
Phosphoinositide Phosphatases (Joint)
Room: Longs/Grays Peak

Speaker 1 of 8
* Lewis C. Cantley, Weill Cornell Medicine, USA

Wednesday, February 16 | 8:00AM - 11:15AM
Phosphoinositide Phosphatases (Joint)
Room: Longs/Grays Peak

Speaker 2 of 8
* Bernard Payrastre, INSERM, France

Wednesday, February 16 | 8:00AM - 11:15AM
Phosphoinositide Phosphatases (Joint)
Room: Longs/Grays Peak

Speaker 3 of 8
Ramon Parsons, Icahn School of Medicine at Mount Sinai, USA
The Role of PTEN Signaling Perturbations in Cancer and in Targeted Therapy

Wednesday, February 16 | 8:00AM - 11:15AM
Phosphoinositide Phosphatases (Joint)
Room: Longs/Grays Peak

Speaker 4 of 8
Jocelyn Laporte, Institute of Genetics and Molecular and Cellular Biology, France
Myotubularins and Associated Neuromuscular Diseases

Wednesday, February 16 | 8:00AM - 11:15AM
Phosphoinositide Phosphatases (Joint)
Room: Longs/Grays Peak

Speaker 5 of 8
Stéphane Schurmans, Universite de Liège, Belgium
Functional Characterization of PI 5-Phosphatases and IP 3-Kinases in Mice

Wednesday, February 16 | 8:00AM - 11:15AM
Phosphoinositide Phosphatases (Joint)
Room: Longs/Grays Peak

Speaker 6 of 8
Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
The Unanticipated Role of an Extended miRNA Proto-Oncogenic Network in the Modulation of PTEN-PI3K Signalling Output

Wednesday, February 16 | 8:00AM - 11:15AM
Phosphoinositide Phosphatases (Joint)
Room: Longs/Grays Peak

Speaker 7 of 8
Christina Anne Mitchell, Monash University, Australia
Short Talk: INPP4B – a Putative Tumour Suppressor in Human Breast Cancer

Wednesday, February 16 | 8:00AM - 11:15AM
Phosphoinositide Phosphatases (Joint)
Room: Longs/Grays Peak

Speaker 8 of 8
Wayne Bowden, Florida International University College of Medicine, USA
Short Talk: Inositol Polyphosphate 4-Phosphatase Type II, INPP4B, is an Androgen Induced Tumor Suppressor in Prostate Cancer

Wednesday, February 16 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 16 | 11:15AM - 1:00PM
Poster Setup
Room: Quandary Peak


Wednesday, February 16 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, February 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Quandary Peak


Wednesday, February 16 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 16 | 5:00PM - 7:00PM
Mouse Models of Class I PI3K in Disease
Room: Longs Peak

Speaker 1 of 4
* Len R. Stephens, Babraham Institute, UK

Wednesday, February 16 | 5:00PM - 7:00PM
Mouse Models of Class I PI3K in Disease
Room: Longs Peak

Speaker 2 of 4
Klaus Okkenhaug, University of Cambridge, UK
PI3K p110delta in T Cell Immunity and Inflammation

Wednesday, February 16 | 5:00PM - 7:00PM
Mouse Models of Class I PI3K in Disease
Room: Longs Peak

Speaker 3 of 4
Emilio Hirsch, Fondazione per la Ricerca Biomedica – ONLUS, Italy
p110gamma in Immunity, Inflammation and Cardiac Context

Wednesday, February 16 | 5:00PM - 7:00PM
Mouse Models of Class I PI3K in Disease
Room: Longs Peak

Speaker 4 of 4
Jean J. Zhao, Dana-Farber Cancer Institute, USA
Targeting PI3K in Cancer, Mechanistic Insights from Genetic Mouse Models

Wednesday, February 16 | 5:00PM - 7:00PM
Inositol Phosphates Signaling
This session is from Inositide Signaling
Room: Grays Peak

Speaker 1 of 5
* John D. York, Vanderbilt University, USA


Wednesday, February 16 | 5:00PM - 7:00PM
Inositol Phosphates Signaling
This session is from Inositide Signaling
Room: Grays Peak

Speaker 2 of 5
Lucio Cocco, University of Bologna, Italy
Nuclear Inositide Signaling (PI-PLCbeta1: from Bench to Clinics)


Wednesday, February 16 | 5:00PM - 7:00PM
Inositol Phosphates Signaling
This session is from Inositide Signaling
Room: Grays Peak

Speaker 3 of 5
Marco Falasca, Curtin University, Australia
Role of Phospholipase C in Cell Metastasis


Wednesday, February 16 | 5:00PM - 7:00PM
Inositol Phosphates Signaling
This session is from Inositide Signaling
Room: Grays Peak

Speaker 4 of 5
John Condeelis, Albert Einstein College of Medicine, USA
Phosphoinositol Regulation of Breast Tumor Cell Chemotaxis and Metastasis


Wednesday, February 16 | 5:00PM - 7:00PM
Inositol Phosphates Signaling
This session is from Inositide Signaling
Room: Grays Peak

Speaker 5 of 5
Chris Noakes, University of Manchester, UK
Short Talk: The PH Domain Proteins IPIP27A and B (Ses1/2) Link OCRL1 to Receptor Recycling in the Endocytic Pathway


Wednesday, February 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary Peak


Wednesday, February 16 | 7:30PM - 10:00PM
Poster Session 3
Room: Quandary Peak


Thursday, February 17 | 7:00AM - 8:00AM
Breakfast
Room: Quandary Peak


Thursday, February 17 | 8:00AM - 11:00AM
PI 3-Kinase Pathway Inhibitors - Preclinical and Clinical St
udies I

Room: Longs Peak

Speaker 1 of 7
* Christian Rommel, F. Hoffmann-La Roche Ltd, Switzerland

Thursday, February 17 | 8:00AM - 11:00AM
PI 3-Kinase Pathway Inhibitors - Preclinical and Clinical St
udies I

Room: Longs Peak

Speaker 2 of 7
Kevan M. Shokat, University of California, San Francisco, USA
Chemical Genetic Investigations of Protein and Lipid Kinase Signaling

Thursday, February 17 | 8:00AM - 11:00AM
PI 3-Kinase Pathway Inhibitors - Preclinical and Clinical St
udies I

Room: Longs Peak

Speaker 3 of 7
Neill A. Giese, USA
Targeting PI3K Delta: A New Paradigm for the Treatment of B Cell Malignancies that Involves the Tumor Cell and it’s Microenvironment

Thursday, February 17 | 8:00AM - 11:00AM
PI 3-Kinase Pathway Inhibitors - Preclinical and Clinical St
udies I

Room: Longs Peak

Speaker 4 of 7
David Finlay, School of Life Sciences, University of Dundee, UK
Akt is dispensable for a T Cell Nutrient Uptake and Metabolism

Thursday, February 17 | 8:00AM - 11:00AM
PI 3-Kinase Pathway Inhibitors - Preclinical and Clinical St
udies I

Room: Longs Peak

Speaker 5 of 7
Gordon B. Mills, University of Texas MD Anderson Cancer Center, USA
A Systems Biology Approach to Monitor the PI3K Pathway

Thursday, February 17 | 8:00AM - 11:00AM
PI 3-Kinase Pathway Inhibitors - Preclinical and Clinical St
udies I

Room: Longs Peak

Speaker 6 of 7
Jordi Rodon, Vall d'hebron University Hospital, Spain
Short Talk: Strategies for Selecting Patients with Tumors Harboring Alterations in the pI3K Pathway in Early Development of PI3K/akt/mTOR Inhibitors

Thursday, February 17 | 8:00AM - 11:00AM
PI 3-Kinase Pathway Inhibitors - Preclinical and Clinical St
udies I

Room: Longs Peak

Speaker 7 of 7
Augustin Amour, GlaxoSmithKline, UK
Short Talk: PI3Kdelta Inhibition: A Future Paradigm for the Inhaled Therapy of Asthma?

Thursday, February 17 | 8:00AM - 11:00AM
Inositides and Ion Channels
This session is from Inositide Signaling
Room: Grays Peak

Speaker 1 of 7
* Shamshad Cockcroft, University College London, UK


Thursday, February 17 | 8:00AM - 11:00AM
Inositides and Ion Channels
This session is from Inositide Signaling
Room: Grays Peak

Speaker 2 of 7
Bertil Hille, University of Washington, USA
PIP2 is a Necessary Cofactor for Ion Channel Function: Biophysical Studies of Phosphoinositides in Living Cells


Thursday, February 17 | 8:00AM - 11:00AM
Inositides and Ion Channels
This session is from Inositide Signaling
Room: Grays Peak

Speaker 3 of 7
Victoria M. Bolotina, Boston Medical Center, USA
Store-Operated Channels: What Makes Them Tick?


Thursday, February 17 | 8:00AM - 11:00AM
Inositides and Ion Channels
This session is from Inositide Signaling
Room: Grays Peak

Speaker 4 of 7
James W. Putney, Jr., NIEHS, National Institutes of Health, USA
Regulation and Physiological Function of Store-Operated Calcium Entry


Thursday, February 17 | 8:00AM - 11:00AM
Inositides and Ion Channels
This session is from Inositide Signaling
Room: Grays Peak

Speaker 5 of 7
Ivan F. Gonzalez, University of Washington, USA
Short Talk: Phosphoinositide Regulation of TRPV1 Sensitization during Inflammatory Hyperalgesia


Thursday, February 17 | 8:00AM - 11:00AM
Inositides and Ion Channels
This session is from Inositide Signaling
Room: Grays Peak

Speaker 6 of 7
Yuxin Mao, Cornell University, USA
Short Talk: Crystal Structure of the Yeast Sac1: Implications for Its Phosphoinositide Phosphatase Function


Thursday, February 17 | 8:00AM - 11:00AM
Inositides and Ion Channels
This session is from Inositide Signaling
Room: Grays Peak

Speaker 7 of 7
Peter Mayinger, Oregon Health and Science University, USA
Short Talk: Metabolic Control of Phosphoinositide Phosphatase Sac1 via the HOG MAP Kinase Pathway and Calcineurin


Thursday, February 17 | 9:00AM - 9:20AM
Coffee Break
Room: Longs Peak Foyer


Thursday, February 17 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Thursday, February 17 | 2:30PM - 4:30PM
Workshop: Experience with PI 3-Kinase Inhibitors in the Clin
ic
Room: Longs Peak
Details to be Announced
Speaker 1 of 1
* José Baselga, Memorial Sloan-Kettering Cancer Center, USA

Thursday, February 17 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, February 17 | 5:00PM - 7:00PM
PI 3-Kinase Pathway Inhibitors - Clinical Studies II
Room: Longs Peak

Speaker 1 of 5
* Lori Friedman, ORIC Pharmaceuticals, USA

Thursday, February 17 | 5:00PM - 7:00PM
PI 3-Kinase Pathway Inhibitors - Clinical Studies II
Room: Longs Peak

Speaker 2 of 5
Langdon Miller, Calistoga Pharmaceuticals Inc, USA
CAL-101 Inhibition of PI3K-delta Demonstrates Clinical and Pharmacodynamic Activity as a New Therapeutic Approach to Lymphoid Malignancies

Thursday, February 17 | 5:00PM - 7:00PM
PI 3-Kinase Pathway Inhibitors - Clinical Studies II
Room: Longs Peak

Speaker 3 of 5
José Baselga, Memorial Sloan-Kettering Cancer Center, USA
Ongoing Clinical Studies with PI3K Inhibitors in Cancer Patients

Thursday, February 17 | 5:00PM - 7:00PM
PI 3-Kinase Pathway Inhibitors - Clinical Studies II
Room: Longs Peak

Speaker 4 of 5
Mika Derynck, Genentech, Inc., USA
Clinical Development Strategies of PI3K/mTOR Inhibitors

Thursday, February 17 | 5:00PM - 7:00PM
PI 3-Kinase Pathway Inhibitors - Clinical Studies II
Room: Longs Peak

Speaker 5 of 5
Jeffrey J. Wallin, Genentech, Inc., USA
Short Talk: Mutant PIK3CA Increases Microtubule Levels and Promotes Resistance to Anti-Mitotic Chemotherapy Drugs

Thursday, February 17 | 5:00PM - 7:00PM
Inositol Polyphosphates Signaling
This session is from Inositide Signaling
Room: Grays Peak

Speaker 1 of 5
* Lucio Cocco, University of Bologna, Italy


Thursday, February 17 | 5:00PM - 7:00PM
Inositol Polyphosphates Signaling
This session is from Inositide Signaling
Room: Grays Peak

Speaker 2 of 5
Adolfo Saiardi, University College London, UK
Are Inositol Pyrophosphates Signaling Molecules?


Thursday, February 17 | 5:00PM - 7:00PM
Inositol Polyphosphates Signaling
This session is from Inositide Signaling
Room: Grays Peak

Speaker 3 of 5
John D. York, Vanderbilt University, USA
Inositol Polyphosphates Kinases


Thursday, February 17 | 5:00PM - 7:00PM
Inositol Polyphosphates Signaling
This session is from Inositide Signaling
Room: Grays Peak

Speaker 4 of 5
Susan R. Wente, Vanderbilt University Medical Center, USA
Little Things that do a lot: Inositol Polyphosphates in DNA Repair


Thursday, February 17 | 5:00PM - 7:00PM
Inositol Polyphosphates Signaling
This session is from Inositide Signaling
Room: Grays Peak

Speaker 5 of 5
Les A. Hanakahi, University of Illinois at Chicago, Rockford Campus, USA
Short Talk: Inositol Polyphosphates: Effect on PI3K-Related Protein Kinase Substrate Selection


Thursday, February 17 | 7:00PM - 7:15PM
Concluding Remarks
Room: Longs Peak

Speaker 1 of 1
* Ramon Parsons, Icahn School of Medicine at Mount Sinai, USA

Thursday, February 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Quandary Peak


Thursday, February 17 | 8:00PM - 11:00PM
Entertainment
Room: Quandary Peak


Thursday, February 17 | 8:00PM - 11:00PM
Cash Bar
Room: Quandary Peak


Friday, February 18 | 10:25AM - 10:25AM
Departure


*Session Chair.