Web Desc
Protection from HIV: Targeted Intervention Strategies
joint with HIV Evolution, Genomics and Pathogenesis
Organizer(s): Mario Roederer, Carolyn Williamson and Robin Shattock
Date: March 20 - 25, 2011
Location: Whistler Conference Centre, Whistler, BC, Canada
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation. Sponsored by Sangamo BioSciences, Inc.
For important information on the coronavirus, please click here
Summary of Meeting:
Biological efforts to prevent HIV infection center on four independent approaches: inducing adaptive immune responses through vaccination, augmenting innate responses, using peri-exposure prophylactic drug therapy, and developing microbicides and/or recombinant antiviral microbial products. While all four of these approaches have promise, they still require significant optimization and further clinical trials. Indeed, successful prevention of HIV infection will likely require a combination of these approaches. Such development efforts require a better understanding of viral and immunological events at the site of transmission. This Keystone Symposia meeting will have a focus on mucosal immunology as well as the interplay between the virus and innate and adaptive immune responses, particularly during the acute phase of the infection. Leading experts in the fields will discuss recent scientific advances in these varied approaches to preventing infection and present data from recent clinical trials testing their efficacy.
Global Health Travel Award Deadline: October 19 2010
Scholarship Deadline: November 22 2010
Discounted Abstract Deadline: November 22 2010
Abstract Deadline: December 22 2010
Discounted Registration Deadline: January 21 2011
We gratefully acknowledge additional support for this conference from:
Bill & Melinda Gates FoundationOffice of AIDS Research, NIHSangamo BioSciences, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI093270-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 20 | 3:00PM - 7:30PM
Registration
Room: Coat Check Area


Sunday, March 20 | 6:15PM - 7:15PM
Refreshments
Room: Grand Foyer/Mountainview


Sunday, March 20 | 7:15PM - 8:30PM
Welcome and Keynote Address: Viral Transmission Dynamics (Jo
int)
Room: Sea to Sky B/C

Speaker 1 of 1
Ashley T. Haase, University of Minnesota, USA
Founder Events at the Portal of Entry in Mucosal Transmission

Monday, March 21 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A/Garibaldi A/B


Monday, March 21 | 8:00AM - 11:00AM
Virus-Specific Microbicides
Room: Sea to Sky B

Speaker 1 of 6
* Robin Shattock, Imperial College London, UK

Monday, March 21 | 8:00AM - 11:00AM
Virus-Specific Microbicides
Room: Sea to Sky B

Speaker 2 of 6
Peter A. Anton, David Geffen School of Medicine at UCLA, USA
Rectal Microbicides: Mucosal Lessons in Developing New Therapies

Monday, March 21 | 8:00AM - 11:00AM
Virus-Specific Microbicides
Room: Sea to Sky B

Speaker 3 of 6
Laurel A. Lagenaur, Osel Inc., USA
“Live” Microbial Prevention Strategies

Monday, March 21 | 8:00AM - 11:00AM
Virus-Specific Microbicides
Room: Sea to Sky B

Speaker 4 of 6
Oliver Hartley, University of Geneva, Switzerland
Targeting CCR5 in HIV Prevention

Monday, March 21 | 8:00AM - 11:00AM
Virus-Specific Microbicides
Room: Sea to Sky B

Speaker 5 of 6
Walid Heneine, Centers for Disease Control and Prevention, USA
Prevention of SHIV Infection in Macaques by Oral and Topical Antiretroviral Prophylaxis

Monday, March 21 | 8:00AM - 11:00AM
Virus-Specific Microbicides
Room: Sea to Sky B

Speaker 6 of 6
Nathalie Dereuddre-Bosquet, Commissariat à l'Energie Atomique, France
Short Talk: MiniCD4 Microbicide Gel Prevents Vaginal Transmission of SHIV162P3 in Cynomolgus Macaques

Monday, March 21 | 8:00AM - 11:00AM
Lentiviral Diversity
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 1 of 6
* Michael Emerman, Fred Hutchinson Cancer Research Center, USA


Monday, March 21 | 8:00AM - 11:00AM
Lentiviral Diversity
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 2 of 6
Reuben S. Harris, University of Minnesota, USA
The Endogenous Origins of HIV G-to-A Hypermutations


Monday, March 21 | 8:00AM - 11:00AM
Lentiviral Diversity
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 3 of 6
Aris Katzourakis, University of Oxford, UK
Endogenous Retroviruses and the Evolution of the Lentiviruses


Monday, March 21 | 8:00AM - 11:00AM
Lentiviral Diversity
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 4 of 6
Michael Worobey, University of Arizona, USA
The Tempo and Mode of SIV and HIV Outbreaks


Monday, March 21 | 8:00AM - 11:00AM
Lentiviral Diversity
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 5 of 6
Frederic Bibollet-Ruche, University of Pennsylvania, USA
Short Talk: A Chimpanzee CD4 Glycosylation Site Polymorphism Governs Susceptibility to SIVcpz Infection


Monday, March 21 | 8:00AM - 11:00AM
Lentiviral Diversity
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 6 of 6
Will Fischer, Los Alamos National Laboratory, USA
Short Talk: Whole-Genome Deep-Sequencing of HIV-1 in the First Weeks, Months, and Years of Infection


Monday, March 21 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer/Mountainview


Monday, March 21 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Monday, March 21 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky A/Grand Foyer


Monday, March 21 | 11:00AM - 12:30PM
Hands-On Computer Workshop on Los Alamos Sequence Database
Room: Fitzsimmons
Maximum attendance: 60. Interested participants may sign up at the meeting on a first-come, first-serve basis.
Instructors: Brian Foley, Karina Yusim, Will Fischer.

Monday, March 21 | 11:00AM - 12:30PM
Hands On Computer Workshop on Los Alamos Sequence Database
This session is from HIV Pathogenesis
Room: Fitzsimmons
Maximum attendance: 60. Interested participants may sign up at the meeting on a first-come, first-serve basis.
Instructors: Brian Foley, Karina Yusim, Will Fischer.


Monday, March 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A/Grand Foyer


Monday, March 21 | 2:30PM - 4:30PM
Workshop 1: Vaccines & Immune Responses
Room: Sea to Sky B

Speaker 1 of 7
* Georgia D. Tomaras, Duke University Medical Center, USA

Monday, March 21 | 2:30PM - 4:30PM
Workshop 1: Vaccines & Immune Responses
Room: Sea to Sky B

Speaker 2 of 7
Shan Lu, University of Massachusetts Medical Center, USA
Identification of a Subset of Primary HIV-1 Env that can Elicit Broader Neutralizing Antibody Responses by a DNA Prime – Protein Boost Vaccination Strategy

Monday, March 21 | 2:30PM - 4:30PM
Workshop 1: Vaccines & Immune Responses
Room: Sea to Sky B

Speaker 3 of 7
David B. Weiner, Wistar Institute, USA
Enhanced DNA Vaccine +/-Protein Boost Delivered by EP Expands B and T Cell Responses and Neutralizing Phenotype in vivo

Monday, March 21 | 2:30PM - 4:30PM
Workshop 1: Vaccines & Immune Responses
Room: Sea to Sky B

Speaker 4 of 7
Penny L. Moore, University of the Witwatersrand and National Institute for Communicable Diseases, South Africa
Development of Broadly Cross-Neutralizing Antibodies is Associated with Delayed HIV Viral Escape

Monday, March 21 | 2:30PM - 4:30PM
Workshop 1: Vaccines & Immune Responses
Room: Sea to Sky B

Speaker 5 of 7
Matthew Johnson, National Institutes of Health, USA
Determinants of Poor Immunogenicity of Alternative Adenoviruses

Monday, March 21 | 2:30PM - 4:30PM
Workshop 1: Vaccines & Immune Responses
Room: Sea to Sky B

Speaker 6 of 7
Jeffrey Teigler, US Military HIV Research Program, USA
Cytokine Secretion Profiles of Adenovirus and Poxvirus Vaccine Vectors in Rhesus Macaques

Monday, March 21 | 2:30PM - 4:30PM
Workshop 1: Vaccines & Immune Responses
Room: Sea to Sky B

Speaker 7 of 7
Michael K.P. Liu, University of Oxford, UK
The Role of The First/Early T Cells In Subjects With Acute HIV-1 Infection

Monday, March 21 | 2:30PM - 4:30PM
Workshop 1: Innate Immune Sensing of Lentiviruses
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 1 of 6
* Olivier Schwartz, Institut Pasteur, France
Innate Sensing of HIV-Infected Cells


Monday, March 21 | 2:30PM - 4:30PM
Workshop 1: Innate Immune Sensing of Lentiviruses
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 2 of 6
Richard M. Dunham, ViiV Healthcare, USA
TLR-Mediated IFNalpha and IDO Production in pDC is Altered in African Green Monkeys


Monday, March 21 | 2:30PM - 4:30PM
Workshop 1: Innate Immune Sensing of Lentiviruses
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 3 of 6
Anna Aldovini, Boston Children's Hospital and Harvard Medical School, USA
HIV-1 Tat Mimics the Activity of Interferons in Primary Human Immature Dendritic Cells and Macrophages


Monday, March 21 | 2:30PM - 4:30PM
Workshop 1: Innate Immune Sensing of Lentiviruses
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 4 of 6
Susanna Marie Bächle, Karolinska Institutet, Sweden
Evolutionary Conservation of Lentiviral Interference with CD1d-Mediated Immunity


Monday, March 21 | 2:30PM - 4:30PM
Workshop 1: Innate Immune Sensing of Lentiviruses
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 5 of 6
Edward Barker, Rush University Medical Center, USA
Vpu Prevents Natural Killer Cell Destruction of HIV-Infected Cells


Monday, March 21 | 2:30PM - 4:30PM
Workshop 1: Innate Immune Sensing of Lentiviruses
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 6 of 6
Mario L. Santiago, University of Colorado Denver, USA
Mechanistic Dissection of the Apobec3/Rfv3 Phenotype: Implications for Improving Retroviral Humoral Immunity


Monday, March 21 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer/Mountainview


Monday, March 21 | 5:00PM - 7:00PM
Clinical Trials Update
Room: Sea to Sky B

Speaker 1 of 4
* M. Juliana McElrath, Fred Hutchinson Cancer Research Center, USA

Monday, March 21 | 5:00PM - 7:00PM
Clinical Trials Update
Room: Sea to Sky B

Speaker 2 of 4
Myron S. Cohen, University of North Carolina at Chapel Hill, USA
Antiretroviral Therapy to Prevent HIV-1: Before and After the(F)Act(s)

Monday, March 21 | 5:00PM - 7:00PM
Clinical Trials Update
Room: Sea to Sky B

Speaker 3 of 4
Nelson L. Michael, Walter Reed Army Institute of Research, USA
Beyond RV 144: Prime Boost Approaches

Monday, March 21 | 5:00PM - 7:00PM
Clinical Trials Update
Room: Sea to Sky B

Speaker 4 of 4
Salim S. Abdool Karim, University of KwaZulu-Natal, South Africa
Update on Microbicide and Pre-exposure Prophylaxis (PrEP) Trials


Monday, March 21 | 5:00PM - 7:00PM
Non-Pathogenic Lentiviral Infections
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 1 of 5
* Anna Aldovini, Boston Children's Hospital and Harvard Medical School, USA


Monday, March 21 | 5:00PM - 7:00PM
Non-Pathogenic Lentiviral Infections
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 2 of 5
Theodora Hatziioannou, Aaron Diamond AIDS Research Center, USA
Towards an animal model for HIV/AIDS


Monday, March 21 | 5:00PM - 7:00PM
Non-Pathogenic Lentiviral Infections
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 3 of 5
Cristian Apetrei, University of Pittsburgh, USA
Pathogenesis of Cross-Species-Transmitted SIV Infection


Monday, March 21 | 5:00PM - 7:00PM
Non-Pathogenic Lentiviral Infections
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 4 of 5
Michaela Müller-Trutwin, Institut Pasteur, France
IFN-I related Responses in Non-pathogenic Versus Pathogenic SIV/HIV Infections


Monday, March 21 | 5:00PM - 7:00PM
Non-Pathogenic Lentiviral Infections
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 5 of 5
Jacob D. Estes, Oregon Health and Science University, USA
Short Talk: Reduced Lymphatic Tissue Immunopathology and Altered Myeloid Lineage Cell Recruitment in SIV-Infected Rhesus Macaques Receiving Anti-TNFalpha Treatment


Monday, March 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grand Foyer/Mountainview


Monday, March 21 | 7:30PM - 10:00PM
Poster Session 1
Room: Sea to Sky A/Grand Foyer


Tuesday, March 22 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A/Garibaldi A/B


Tuesday, March 22 | 8:00AM - 11:15AM
Correlates of Protection
Room: Sea to Sky B

Speaker 1 of 7
* † Eric Hunter, Emory University, USA

Tuesday, March 22 | 8:00AM - 11:15AM
Correlates of Protection
Room: Sea to Sky B

Speaker 2 of 7
Jo-Ann S. Passmore, University of Cape Town, South Africa
Correlates of Protection against HIV Infection in the Female Genital Tract

Tuesday, March 22 | 8:00AM - 11:15AM
Correlates of Protection
Room: Sea to Sky B

Speaker 3 of 7
Susan W. Barnett, Bill & Melinda Gates Foundation, USA
Protective Vaccine-Induced Humoral Responses

Tuesday, March 22 | 8:00AM - 11:15AM
Correlates of Protection
Room: Sea to Sky B

Speaker 4 of 7
Anuradha Ganesan, Anuradha Ganesan, USA
Early Immunologic and Virologic Correlates of Protection



Tuesday, March 22 | 8:00AM - 11:15AM
Correlates of Protection
Room: Sea to Sky B

Speaker 5 of 7
Ravi Tandon, John A. Burns School of Medicine, University of Hawai'i, USA
Short Talk: HERV Specific T Cell Responses in Vertically HIV-1 Infected Children are Inversely Correlated with HIV-1 Plasma Viral Load

Tuesday, March 22 | 8:00AM - 11:15AM
Correlates of Protection
Room: Sea to Sky B

Speaker 6 of 7
Monica Vaccari, NCI, National Institutes of Health, USA
Short Talk: Efficacy of HIV Vaccine Candidate in Macaques Dependent on the Dose of SIVmac251 Challenge Exposure

Tuesday, March 22 | 8:00AM - 11:15AM
Correlates of Protection
Room: Sea to Sky B

Speaker 7 of 7
M. Juliana McElrath, Fred Hutchinson Cancer Research Center, USA
Cellular Immune Responses Induced by HIV Vaccines

Tuesday, March 22 | 8:00AM - 11:00AM
Evolution of Pathogenicity
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 1 of 5
* Cristian Apetrei, University of Pittsburgh, USA


Tuesday, March 22 | 8:00AM - 11:00AM
Evolution of Pathogenicity
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 2 of 5
Guido Silvestri, Emory University School of Medicine, USA
Protection of Central Memory CD4+ T Cell Homeostasis in Natural SIV Hosts


Tuesday, March 22 | 8:00AM - 11:00AM
Evolution of Pathogenicity
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 3 of 5
Michael Emerman, Fred Hutchinson Cancer Research Center, USA
Paleovirology and the Evolution of Primate Antiviral Defenses


Tuesday, March 22 | 8:00AM - 11:00AM
Evolution of Pathogenicity
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 4 of 5
Sebastian L. Bonhoeffer, ETH-Zentrum, Switzerland
Tracing Epidemiological Patterns in Sequence Data: Transmission Structure, Basic Reproductive Rate, and Heritability of Virus Load


Tuesday, March 22 | 8:00AM - 11:00AM
Evolution of Pathogenicity
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 5 of 5
Nichole R. Klatt, University of Miami, USA
Short Talk: Mechanisms Underlying Damage to the Mucosal Barrier and Immune Activation after Pathogenic SIV Infection of Rhesus Macaques


Tuesday, March 22 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer/Mountainview


Tuesday, March 22 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Tuesday, March 22 | 11:15AM - 1:00PM
Poster Setup
Room: Sea to Sky A/Grand Foyer


Tuesday, March 22 | 11:15AM - 12:30PM
Hands On Computer Workshop on Los Los Alamos Sequence Databa
se
Room: Fitzsimmons
Maximum attendance: 60. Interested participants may sign up at the meeting on a first-come, first-serve basis.
Instructors: Brian Foley, Karina Yusim, Will Fischer.

Tuesday, March 22 | 11:15AM - 12:30PM
Hands On Computer Workshop on Los Alamos Sequence Database
This session is from HIV Pathogenesis
Room: Fitzsimmons
Maximum attendance: 60. Interested participants may sign up at the meeting on a first-come, first-serve basis.
Instructors: Brian Foley, Karina Yusim, Will Fischer.


Tuesday, March 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A/Grand Foyer


Tuesday, March 22 | 2:30PM - 4:30PM
Workshop 2: Mucosal Immunology and Microbicides
Room: Sea to Sky B

Speaker 1 of 7
* Jo-Ann S. Passmore, University of Cape Town, South Africa

Tuesday, March 22 | 2:30PM - 4:30PM
Workshop 2: Mucosal Immunology and Microbicides
Room: Sea to Sky B

Speaker 2 of 7
Carolina Herrera, Imperial College, UK
Combinations of Maraviroc and Reverse Transcriptase Inhibitors as Potential Microbicides

Tuesday, March 22 | 2:30PM - 4:30PM
Workshop 2: Mucosal Immunology and Microbicides
Room: Sea to Sky B

Speaker 3 of 7
Peter D. Katsikis, Drexel University College of Medicine, USA
Anti-Viral and Anti-Inflammatory Dual Acting Microbicide for HIV-1 Infection

Tuesday, March 22 | 2:30PM - 4:30PM
Workshop 2: Mucosal Immunology and Microbicides
Room: Sea to Sky B

Speaker 4 of 7
Ramesh K. Akkina, Colorado State University, USA
Oral Pre-Exposure Prophylaxis by Anti-Retrovirals Raltegravir and Maraviroc Protects against HIV-1 Vaginal Transmission in a Humanized Mouse Model

Tuesday, March 22 | 2:30PM - 4:30PM
Workshop 2: Mucosal Immunology and Microbicides
Room: Sea to Sky B

Speaker 5 of 7
Jean-Charles J. B. Grivel, Sidra Medical and Research Center, Qatar
Infection of Cervical Tissue Explants with Transmitted/Founder HIV-1 Viruses

Tuesday, March 22 | 2:30PM - 4:30PM
Workshop 2: Mucosal Immunology and Microbicides
Room: Sea to Sky B

Speaker 6 of 7
Steven L. Zeichner, University of Virginia, USA
HIV Human Vaginal Microbicide Effects on the Vaginal Microbial Community

Tuesday, March 22 | 2:30PM - 4:30PM
Workshop 2: Mucosal Immunology and Microbicides
Room: Sea to Sky B

Speaker 7 of 7
Natasa Strbo, School of Medicine, University of Miami, USA
Profound Mucosal CD8+ T Cell Immunity Elicited by Intraperitoneal Immunization with Secreted Heat Shock Protein gp96-Ig

Tuesday, March 22 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer/Mountainview


Tuesday, March 22 | 5:00PM - 7:00PM
Viral Variation from Transmission to Populations (Joint)
Room: Sea to Sky B/C

Speaker 1 of 5
* Michael Worobey, University of Arizona, USA

Tuesday, March 22 | 5:00PM - 7:00PM
Viral Variation from Transmission to Populations (Joint)
Room: Sea to Sky B/C

Speaker 2 of 5
Andrew Leigh-Brown, University of Edinburgh, Scotland
HIV Transmission Dynamics

Tuesday, March 22 | 5:00PM - 7:00PM
Viral Variation from Transmission to Populations (Joint)
Room: Sea to Sky B/C

Speaker 3 of 5
Carolyn Williamson, University of Cape Town, South Africa
Early Viral Evolution and Escape in Subtype C Infected Individuals with Single- and Super-Infection

Tuesday, March 22 | 5:00PM - 7:00PM
Viral Variation from Transmission to Populations (Joint)
Room: Sea to Sky B/C

Speaker 4 of 5
Jessica L. Prince, Emory University, USA
Short Talk: The Role of Transmitted HLA Associated Gag Polymorphisms in Defining HIV-1 Set-Point Viral Load and in vitro Replicative Fitness

Tuesday, March 22 | 5:00PM - 7:00PM
Viral Variation from Transmission to Populations (Joint)
Room: Sea to Sky B/C

Speaker 5 of 5
Brandon F. Keele, Frederick National Laboratory, USA
Modeling HIV Transmission and Early Evolution in Nonhuman Primates

Tuesday, March 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grand Foyer/Mountainview


Tuesday, March 22 | 7:30PM - 10:00PM
Poster Session 2
Room: Sea to Sky A/Grand Foyer


Wednesday, March 23 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A/Garibaldi A/B


Wednesday, March 23 | 8:00AM - 11:15AM
Humoral Responses
Room: Sea to Sky B

Speaker 1 of 6
* Nancy L. Haigwood, Oregon Health & Science University, USA

Wednesday, March 23 | 8:00AM - 11:15AM
Humoral Responses
Room: Sea to Sky B

Speaker 2 of 6
Peter D. Kwong, NIAID, National Institutes of Health, USA
Prospects for Generating VRC01-like Antibodies Revealed by Crystal Structures and 454 Pyrosequencing

Wednesday, March 23 | 8:00AM - 11:15AM
Humoral Responses
Room: Sea to Sky B

Speaker 3 of 6
John R. Mascola, NIAID, National Institutes of Health, USA
Isolation and Characterization of Broadly Neutralizing Monoclonal Antibodies to HIV-1

Wednesday, March 23 | 8:00AM - 11:15AM
Humoral Responses
Room: Sea to Sky B

Speaker 4 of 6
Nancy L. Haigwood, Oregon Health & Science University, USA
Short Talk: Passive Transfer of Physiologic Levels of Neutralizing IgG Results in Profound Control of Plasma Virus in Newborn Rhesus Macaques Orally Exposed to SHIV-SF162P3 and Protects B Cells in vivo

Wednesday, March 23 | 8:00AM - 11:15AM
Humoral Responses
Room: Sea to Sky B

Speaker 5 of 6
Shannon A. Allen, Northwestern University Feinberg School of Medicine, USA
Short Talk: Neutralizing and Non-Neutralizing HIV-Specific Antibodies Hinder the Movement of Virus in Fresh Human Cervical Mucus

Wednesday, March 23 | 8:00AM - 11:15AM
Humoral Responses
Room: Sea to Sky B

Speaker 6 of 6
Lynn Morris, National Institute for Communicable Diseases, South Africa
Interplay between Autologous and Broadly Cross-Reactive Neutralizing Antibodies in HIV-1 Infection

Wednesday, March 23 | 8:00AM - 11:00AM
Host Genome I: The Variable Human Genome
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 1 of 5
* Frederic D. Bushman, University of Pennsylvania, USA


Wednesday, March 23 | 8:00AM - 11:00AM
Host Genome I: The Variable Human Genome
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 2 of 5
David B. Goldstein, Duke University, USA
Whole Genome Sequencing and the Host Genetics of HIV-1 Acquisition and Viral Control


Wednesday, March 23 | 8:00AM - 11:00AM
Host Genome I: The Variable Human Genome
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 3 of 5
Manolis Emmanouil T. Dermitzakis, University of Geneva Medical School, Switzerland
Human Cellular Quantitative Genetics


Wednesday, March 23 | 8:00AM - 11:00AM
Host Genome I: The Variable Human Genome
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 4 of 5
Monsef Benkirane, Institut de Genetique Humaine, France
Identification of an HIV Restriction Fsctor in DCs


Wednesday, March 23 | 8:00AM - 11:00AM
Host Genome I: The Variable Human Genome
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 5 of 5
Amalio Telenti, Centre Hospitalier Universitaire Vaudois, Switzerland
Host and Pathogen Evolution at Genome Scale


Wednesday, March 23 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer/Mountainview


Wednesday, March 23 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Wednesday, March 23 | 11:15AM - 1:00PM
Poster Setup
Room: Sea to Sky A/Grand Foyer


Wednesday, March 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A/Grand Foyer


Wednesday, March 23 | 2:30PM - 4:30PM
Workshop 2: HIV/Host Interactions
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 1 of 7
* Vicente Planelles, University of Utah, USA
Homeostatic Proliferation of Central Memory T Cells and the Latent HIV-1 Reservoir


Wednesday, March 23 | 2:30PM - 4:30PM
Workshop 2: HIV/Host Interactions
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 2 of 7
Mathias Lichterfeld, Brigham and Women's Hospital, USA
An Intrinsic Inhibitor of CDK9-Mediated Transcriptional Elongation of HIV-1 in CD4 T Cells from Elite Controllers


Wednesday, March 23 | 2:30PM - 4:30PM
Workshop 2: HIV/Host Interactions
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 3 of 7
Vincent Piguet, Cardiff University, UK
Quantitative Multicolour Super-Resolution Microscopy Reveals Tetherin HIV-1 Interaction


Wednesday, March 23 | 2:30PM - 4:30PM
Workshop 2: HIV/Host Interactions
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 4 of 7
Suzanne Willey, Kings College London, UK
Analysis of Tetherin Antagonism by HIV-1 Vpu and HIV-2 Env Alleles Isolated from Infected Individuals


Wednesday, March 23 | 2:30PM - 4:30PM
Workshop 2: HIV/Host Interactions
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 5 of 7
Rogier W. Sanders, University of Amsterdam and Weill Cornell Medical College, Netherlands
HIV-1 N-Glycan Composition Governs a Balance between Dendritic Cell-Mediated Viral Transmission and Degradation


Wednesday, March 23 | 2:30PM - 4:30PM
Workshop 2: HIV/Host Interactions
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 6 of 7
David R. Graham, Johns Hopkins School of Medicine, USA
An Update on HIV Proteomics: Comparisons between Macrophage and T Cell Derived HIV-1


Wednesday, March 23 | 2:30PM - 4:30PM
Workshop 2: HIV/Host Interactions
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 7 of 7
Nuria Izquierdo-Useros, AIDS Research Institute Irsicaixa, Spain
Live Cell Imaging of Cell-Associated Viral Capture by Mature Dendritic Cells


Wednesday, March 23 | 2:30PM - 4:30PM
Workshop: Data Sharing: A Priority of the Enterprise 2010 Sc
ientific Strategic Plan
Room: Fitzsimmons

Speaker 1 of 3
* Yegor Voronin, Worcester HIV Vaccine, USA

Wednesday, March 23 | 2:30PM - 4:30PM
Workshop: Data Sharing: A Priority of the Enterprise 2010 Sc
ientific Strategic Plan
Room: Fitzsimmons

Speaker 2 of 3
* Lynn Morris, National Institute for Communicable Diseases, South Africa

Wednesday, March 23 | 2:30PM - 4:30PM
Workshop: Data Sharing: A Priority of the Enterprise 2010 Sc
ientific Strategic Plan
Room: Fitzsimmons

Speaker 3 of 3
* Douglas D. Richman, University of California, San Diego, USA

Wednesday, March 23 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer/Mountainview


Wednesday, March 23 | 5:00PM - 7:00PM
The Earliest Responses and Host Genetics
Room: Sea to Sky B

Speaker 1 of 5
* Thomas J. Hope, Northwestern University, USA

Wednesday, March 23 | 5:00PM - 7:00PM
The Earliest Responses and Host Genetics
Room: Sea to Sky B

Speaker 2 of 5
Galit Alter, MIT and Harvard University, USA
Innate Recognition: NK Cells

Wednesday, March 23 | 5:00PM - 7:00PM
The Earliest Responses and Host Genetics
Room: Sea to Sky B

Speaker 3 of 5
Christian L. Boutwell, General Hospital Corporation, USA
Short Talk: Ultra-Deep Whole Genome HIV Sequencing Reveals the Impact of Viral Adaptation on Immune Control During Acute Infection

Wednesday, March 23 | 5:00PM - 7:00PM
The Earliest Responses and Host Genetics
Room: Sea to Sky B

Speaker 4 of 5
Georgia D. Tomaras, Duke University Medical Center, USA
Analysis of the Envelope B Cell Repertoire in the Thai RV144 Efficacy Trial

Wednesday, March 23 | 5:00PM - 7:00PM
The Earliest Responses and Host Genetics
Room: Sea to Sky B

Speaker 5 of 5
Andrew J. McMichael, Oxford University, UK
T Cell Responses, HLA B*57 and Control of Viremia in Acute HIV-1 Infection

Wednesday, March 23 | 5:00PM - 7:00PM
Host Genome II: Host Genome and Retroviral Infection
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 1 of 5
* Amalio Telenti, Centre Hospitalier Universitaire Vaudois, Switzerland


Wednesday, March 23 | 5:00PM - 7:00PM
Host Genome II: Host Genome and Retroviral Infection
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 2 of 5
Frederic D. Bushman, University of Pennsylvania, USA
HIV DNA Integration and RNA Splicing Studied using Deep Sequencing


Wednesday, March 23 | 5:00PM - 7:00PM
Host Genome II: Host Genome and Retroviral Infection
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 3 of 5
Angela Ciuffi, Institute of Microbiology - CHUV/UNIL, Switzerland
Host Transcriptional Reprogramming during the HIV Life Cycle


Wednesday, March 23 | 5:00PM - 7:00PM
Host Genome II: Host Genome and Retroviral Infection
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 4 of 5
Paul de Bakker, Vertex Pharmaceuticals, USA
Unravelling the Genetic Contributions of MHC Variation to Durable Host Control of HIV-1


Wednesday, March 23 | 5:00PM - 7:00PM
Host Genome II: Host Genome and Retroviral Infection
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 5 of 5
Nick Schopman, University of Amsterdam, Netherlands
Short Talk: Deep Sequencing of Small RNAs from HIV-1 Infected Cells Reveals Possible HIV-Encoded miRNAs


Wednesday, March 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grand Foyer/Mountainview


Wednesday, March 23 | 7:30PM - 10:00PM
Poster Session 3
Room: Sea to Sky A/Grand Foyer


Thursday, March 24 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A/Garibaldi A/B


Thursday, March 24 | 7:30AM - 8:00AM
Poster Setup
Room: Sea to Sky A/Grand Foyer


Thursday, March 24 | 8:00AM - 5:00PM
Poster Viewing
Room: Sea to Sky A/Grand Foyer


Thursday, March 24 | 8:00AM - 11:15AM
Cellular Vaccines
Room: Sea to Sky B

Speaker 1 of 7
* † Richard A. Koup, NIAID, National Institutes of Health, USA

Thursday, March 24 | 8:00AM - 11:15AM
Cellular Vaccines
Room: Sea to Sky B

Speaker 2 of 7
R. Paul Johnson, Harvard Medical School, USA
Maturation of Protective Immunity Induced by Live Attenuated SIV

Thursday, March 24 | 8:00AM - 11:15AM
Cellular Vaccines
Room: Sea to Sky B

Speaker 3 of 7
Willem A. Hanekom, Bill & Melinda Gates Foundation, USA
Correlates of Protection following Vaccination against TB

Thursday, March 24 | 8:00AM - 11:15AM
Cellular Vaccines
Room: Sea to Sky B

Speaker 4 of 7
Norman L. Letvin, Beth Israel Deaconess Medical Center, USA
Genetic Determinants of Vaccine Protection in Rhesus Monkeys

Thursday, March 24 | 8:00AM - 11:15AM
Cellular Vaccines
Room: Sea to Sky B

Speaker 5 of 7
Neil Almond, National Institute Biology Standards, UK
Short Talk: Conditional Live Attenuated SIVrtTA Protects Against Heterologous SIVsmE660

Thursday, March 24 | 8:00AM - 11:15AM
Cellular Vaccines
Room: Sea to Sky B

Speaker 6 of 7
Maria H. Foley, Massachusetts Institute of Technology, USA
Short Talk: Time-Lapse Video Microscopy of HIV-Specific CTL: The Effects of Cell Motility and TCR Avidity on Target Engagement and Killing

Thursday, March 24 | 8:00AM - 11:15AM
Cellular Vaccines
Room: Sea to Sky B

Speaker 7 of 7
Louis J. Picker, Oregon Health & Science University, USA
Live Vectors - CMV

Thursday, March 24 | 8:00AM - 11:00AM
HIV Host Interactions
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 1 of 6
* Theodora Hatziioannou, Aaron Diamond AIDS Research Center, USA


Thursday, March 24 | 8:00AM - 11:00AM
HIV Host Interactions
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 2 of 6
Vineet N. KewalRamani, NCI, National Institutes of Health, USA
Genetics of HIV Entry into the Nucleus


Thursday, March 24 | 8:00AM - 11:00AM
HIV Host Interactions
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 3 of 6
Jeremy Luban, University of Massachusetts Medical School, USA
TRIM5 is an Innate Immune Sensor for the Capsid of HIV-1 and Other Retroviruses


Thursday, March 24 | 8:00AM - 11:00AM
HIV Host Interactions
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 4 of 6
Li Wu, Ohio State University, USA
HIV Interactions with Dendritic Cells


Thursday, March 24 | 8:00AM - 11:00AM
HIV Host Interactions
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 5 of 6
Thomas J. Hope, Northwestern University, USA
Short Talk: Reverse Transcription Facilitates HIV Uncoating


Thursday, March 24 | 8:00AM - 11:00AM
HIV Host Interactions
This session is from HIV Pathogenesis
Room: Sea to Sky C

Speaker 6 of 6
Benjamin K. Chen, Mount Sinai School of Medicine, USA
Short Talk: Neutralization Resistance of HIV-1 Virological Synapse-Mediated Infection is Regulated by Env Cytoplasmic Tail


Thursday, March 24 | 9:00AM - 9:20AM
Coffee Break
Room: Grand Foyer/Mountainview


Thursday, March 24 | 11:15AM - 12:15PM
Lunch
Room: Sea to Sky A/Garibaldi A/B


Thursday, March 24 | 12:15PM - 2:30PM
Poster Session 4
Room: Sea to Sky A/Grand Foyer


Thursday, March 24 | 2:30PM - 4:30PM
Workshop 3: The NHP Model - Limitations and Lessons
Room: Sea to Sky B/C

Speaker 1 of 7
* Brandon F. Keele, Frederick National Laboratory, USA

Thursday, March 24 | 2:30PM - 4:30PM
Workshop 3: The NHP Model - Limitations and Lessons
Room: Sea to Sky B/C

Speaker 2 of 7
Thomas Lehner, Guy's, King's & St. Thomas' Hospital Medical and Dental School, UK
A Protective Allo-Immune Strategy Utilising Serum and Mucosal Antibodies and APOBEC3G

Thursday, March 24 | 2:30PM - 4:30PM
Workshop 3: The NHP Model - Limitations and Lessons
Room: Sea to Sky B/C

Speaker 3 of 7
Matthew R. Reynolds, University of Wisconsin-Madison, USA
Testing the Efficacy of the STEP Trial Recombinant Ad5 gag/pol/nef Vaccine Regimen in Rhesus Macaques using a Limiting Dose Heterologous SIV Challenge

Thursday, March 24 | 2:30PM - 4:30PM
Workshop 3: The NHP Model - Limitations and Lessons
Room: Sea to Sky B/C

Speaker 4 of 7
Barbara K. Felber, NCI, National Institutes of Health, USA
SIVmac239 DNA and Virus Particle Vaccination Confers Protection Upon Mucosal Challenge With Heterologous SIVsmE660

Thursday, March 24 | 2:30PM - 4:30PM
Workshop 3: The NHP Model - Limitations and Lessons
Room: Sea to Sky B/C

Speaker 5 of 7
Jorge Ramos de Almeida, NIAID, National Institutes of Health, USA
CD8+ T Cell Public Clonotype Usage in a Single Epitope-Specific Response in Acute SIV Infection of Mamu-B*08 Positive Rhesus Macaques may Determine Control of Viral Replication

Thursday, March 24 | 2:30PM - 4:30PM
Workshop 3: The NHP Model - Limitations and Lessons
Room: Sea to Sky B/C

Speaker 6 of 7
Philip Mudd, University of Wisconsin - Madison, USA
Reduction of CD4+ T Cells in vivo does not affect Virus Load in Macaque Elite Controllers

Thursday, March 24 | 2:30PM - 4:30PM
Workshop 3: The NHP Model - Limitations and Lessons
Room: Sea to Sky B/C

Speaker 7 of 7
Pamela J. Skinner, University of Minnesota, USA
Location, Abundance, and Activation/Proliferation Status of SIV-Specific CD8 T Cells in situ in SIVdeltanef Immunized SIVmac251 Challenged Rhesus Macaques

Thursday, March 24 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer/Mountainview


Thursday, March 24 | 5:00PM - 7:00PM
Targeting Mucosal and T Cell Immunity (Joint)
Room: Sea to Sky B/C

Speaker 1 of 5
* Peter A. Anton, David Geffen School of Medicine at UCLA, USA

Thursday, March 24 | 5:00PM - 7:00PM
Targeting Mucosal and T Cell Immunity (Joint)
Room: Sea to Sky B/C

Speaker 2 of 5
Elena Martinelli, Population Council, USA
Virus-Cell Interplay and Modulation of Immune Function

Thursday, March 24 | 5:00PM - 7:00PM
Targeting Mucosal and T Cell Immunity (Joint)
Room: Sea to Sky B/C

Speaker 3 of 5
James B. Whitney, Beth Israel Deaconess Medical Center, Harvard University, USA
Short Talk: Reduction of Founder/Transmitted Virus in Vaccinated Monkeys after Mucosal SIV Challenge

Thursday, March 24 | 5:00PM - 7:00PM
Targeting Mucosal and T Cell Immunity (Joint)
Room: Sea to Sky B/C

Speaker 4 of 5
Robin Shattock, Imperial College London, UK
Combining Prevention Technologies: Vaccines and Microbicides

Thursday, March 24 | 5:00PM - 7:00PM
Targeting Mucosal and T Cell Immunity (Joint)
Room: Sea to Sky B/C

Speaker 5 of 5
Mario Roederer, NIAID, National Institutes of Health, USA
Identification and Characterization of T Memory Stem Cells in Humans and NHP: Implication for Vaccine Design

Thursday, March 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grand Foyer/Mountainview


Thursday, March 24 | 8:00PM - 11:00PM
Entertainment
Room: Sea to Sky A


Thursday, March 24 | 8:00PM - 11:00PM
Cash Bar
Room: Sea to Sky A


Friday, March 25 | 10:22AM - 10:22AM
Departure


*Session Chair
†Invited, not yet responded.