Web Desc
Drugs from Bugs: The Anti-Inflammatory Drugs of Tomorrow
joint with Evolving Approaches to Early-Stage Drug Discovery
Organizer(s): Padraic G. Fallon, Grant McFadden and Amanda E.I. Proudfoot Fichard
Date: April 03 - 07, 2011
Location: Snowbird Resort, Snowbird, UT, USA
Supported by the Directors' Fund
For important information on the coronavirus, please click here
Summary of Meeting:
A recent global trend is that fewer novel therapeutics are progressing from the biopharmaceutical pipeline to the clinic. This has prompted the drug research and development sector to adopt less conventional approaches in broadening the search for new drugs. In this meeting we will examine the growing opportunities for discovery of novel drugs from pathogens, or the “drugs from bugs” approach. The genome of man is the product of the evolution of humans adapting to environmental factors, with infectious pathogens exerting potent selective pressure. Some of the major immune-mediated diseases of today are associated with genes that evolved to respond to pathogens. Novel therapeutic strategies and new drugs can be developed by both understanding how pathogens modulate and usurp the immune system, and also by identifying the functional molecules from pathogens. Indeed, a new generation of pathogen-derived immune modulating molecules is now in clinical trials. In this meeting leading experts will present the current status of the use of pathogens as a depository for new therapeutics. This forum will be an opportunity for industry to engage with academics for the development of novel strategies for drug discovery. This meeting will bring together cross-disciplinary scientists to exchange and share ideas, and thereby foster collaborations on the generation of new drug strategies for the future.
Scholarship Deadline: December 2 2010
Discounted Abstract Deadline: December 2 2010
Abstract Deadline: January 4 2011
Discounted Registration Deadline: February 3 2011
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Pfizer Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI094907-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, April 03 | 3:00PM - 7:30PM
Registration
Room: Ballroom Lobby


Sunday, April 03 | 6:15PM - 7:15PM
Refreshments
Room: Ballroom Lobby


Sunday, April 03 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Ballroom 3

Speaker 1 of 2
* Grant McFadden, University of Florida, USA

Sunday, April 03 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Ballroom 3

Speaker 2 of 2
Jose-Carlos Gutierrez-Ramos, Pfizer, Inc, USA
Anti-Inflammatory Drugs: The Path from Discovery to the Clinic

Monday, April 04 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Monday, April 04 | 8:00AM - 11:00AM
Immune Modulating Molecules from Pathogens
Room: Ballroom 3

Speaker 1 of 4
Antonio Alcami, Centro de Biologia Molecular Severo Ochoa, Spain
Therapeutic Exploitation of Viral Chemokine Modulators

Monday, April 04 | 8:00AM - 11:00AM
Immune Modulating Molecules from Pathogens
Room: Ballroom 3

Speaker 2 of 4
* Grant McFadden, University of Florida, USA
When the Bug is the Drug: Exploiting Poxviruses for Oncolytic Virotherapy

Monday, April 04 | 8:00AM - 11:00AM
Immune Modulating Molecules from Pathogens
Room: Ballroom 3

Speaker 3 of 4
William Harnett, Strathclyde Institute for Pharmacy and Biomedical Sciences, UK
The Path from a Pathogen Molecule to Synthetic Anti-Inflammatory Mimetics: The ES-62 Story

Monday, April 04 | 8:00AM - 11:00AM
Immune Modulating Molecules from Pathogens
Room: Ballroom 3

Speaker 4 of 4
Paola Zaccone, University of Cambridge, UK
Short Talk: The S. mansoni Glycoprotein Omega-1 Induces Foxp3 Expression in NOD Mouse CD4+ T Cells

Monday, April 04 | 8:00AM - 11:00AM
Evolving Strategies for Screening and Early Lead Identificat
ion
This session is from Early-Stage Drug Discovery

Room: Ballroom 2

Speaker 1 of 5
Timothy A. Grese, Lilly Research Laboratories, USA
PD2: New Collaborative Models for Early Stage Drug Discovery


Monday, April 04 | 8:00AM - 11:00AM
Evolving Strategies for Screening and Early Lead Identificat
ion
This session is from Early-Stage Drug Discovery

Room: Ballroom 2

Speaker 2 of 5
Robert J. Gould, Fulcrum Therapeutics, USA
Protein Methyl Transferase Inhibitors: Targeted Therapeutics for Targeted Patients


Monday, April 04 | 8:00AM - 11:00AM
Evolving Strategies for Screening and Early Lead Identificat
ion
This session is from Early-Stage Drug Discovery

Room: Ballroom 2

Speaker 3 of 5
Miles Congreve, Heptares Therapeutics Ltd, UK
Fragment-Based Screening Approaches to GPCR Targets


Monday, April 04 | 8:00AM - 11:00AM
Evolving Strategies for Screening and Early Lead Identificat
ion
This session is from Early-Stage Drug Discovery

Room: Ballroom 2

Speaker 4 of 5
Linda Brady, NIMH, National Institutes of Health, USA
Probe Development within the Molecular Libraries Probe Production Centers Network (MLPCN): Leads for Drug Development from Previously Intractable Targets


Monday, April 04 | 8:00AM - 11:00AM
Evolving Strategies for Screening and Early Lead Identificat
ion
This session is from Early-Stage Drug Discovery

Room: Ballroom 2

Speaker 5 of 5
Peter L. Toogood, Lycera Corporation, USA
Short Talk: Autoimmune Disease Modification through Mitochondrial Bioenergetics


Monday, April 04 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Monday, April 04 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch/Maybird


Monday, April 04 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Monday, April 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch/Maybird


Monday, April 04 | 2:30PM - 4:30PM
Workshop 1: Recent Advances in Drug Discovery from Pathogens
Room: Ballroom 3

Speaker 1 of 7
* Alexandra R. Lucas, Arizona State University, USA

Monday, April 04 | 2:30PM - 4:30PM
Workshop 1: Recent Advances in Drug Discovery from Pathogens
Room: Ballroom 3

Speaker 2 of 7
Mattias Collin, Lund University, Sweden
Bacterial Enzymes Hydrolyzing Antibody Glycans as a Novel Anti-Inflammatory Therapeutic Principle

Monday, April 04 | 2:30PM - 4:30PM
Workshop 1: Recent Advances in Drug Discovery from Pathogens
Room: Ballroom 3

Speaker 3 of 7
Christian Rueter, Universität Münster, Germany
’From Saulus to Paulus ’: A Pathogen-Derived Cell-Penetrating Immune Modulator for the Treatment of Inflammatory Bowel Diseases

Monday, April 04 | 2:30PM - 4:30PM
Workshop 1: Recent Advances in Drug Discovery from Pathogens
Room: Ballroom 3

Speaker 4 of 7
Miguel A. Pineda, Institute of Infection Immunity and Inflammation, UK
Investigation of Whether the Filarial Nematode Product ES-62 Ameliorates Collagen-Induced Arthritis by Targeting the IL-17 Inflammatory Axis

Monday, April 04 | 2:30PM - 4:30PM
Workshop 1: Recent Advances in Drug Discovery from Pathogens
Room: Ballroom 3

Speaker 5 of 7
Lothar Steidler, ActoBio Therapeutics, Belgium
Prevention of Experimental Oral Mucositis in Hamsters by a Mouth Rinse Formulation with Human Trefoil Factor 1-Secreting Lactococcus lactis

Monday, April 04 | 2:30PM - 4:30PM
Workshop 1: Recent Advances in Drug Discovery from Pathogens
Room: Ballroom 3

Speaker 6 of 7
Mordechay Gerlic, Sackler Faculty of Medicine, Tel Aviv University, Israel
Vaccinia Virus F1L Protein Inhibits NLRP1 Inflammasome Activation and Promotes Virulence

Monday, April 04 | 2:30PM - 4:30PM
Workshop 1: Recent Advances in Drug Discovery from Pathogens
Room: Ballroom 3

Speaker 7 of 7
Maria L. Higuchi, São Paulo University School of Medicine, Brazil
Trans-Sialidase from Trypanosoma Cruzi : An Anti-Atherosclerotic Drug

Monday, April 04 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Monday, April 04 | 5:00PM - 7:15PM
Pathogen Modulators of Immune-Mediated Diseases
Room: Ballroom 3

Speaker 1 of 4
* Anne Cooke, University of Cambridge, UK
Modulation of Autoimmunity by Pathogen Derived Molecules

Monday, April 04 | 5:00PM - 7:15PM
Pathogen Modulators of Immune-Mediated Diseases
Room: Ballroom 3

Speaker 2 of 4
Cathryn R. Nagler, University of Chicago, USA
The Commensal Microbiota and the Regulation of Allergic Disease

Monday, April 04 | 5:00PM - 7:15PM
Pathogen Modulators of Immune-Mediated Diseases
Room: Ballroom 3

Speaker 3 of 4
Sarkis K. Mazmanian, California Institute of Technology, USA
Exploiting Commensal Immune Modulation for New Drugs

Monday, April 04 | 5:00PM - 7:15PM
Pathogen Modulators of Immune-Mediated Diseases
Room: Ballroom 3

Speaker 4 of 4
Padraic Fallon, Trinity College Dublin, Ireland
Who Needs Anti-Inflammatory Drugs when a Bug will Do?

Monday, April 04 | 5:00PM - 7:00PM
Novel Approaches and Technology for Early Stage Drug Discove
ry
This session is from Early-Stage Drug Discovery

Room: Ballroom 2

Speaker 1 of 3
Bryan Roth, University of North Carolina at Chapel Hill, USA
Identifying New Molecular Targets for Known Drugs


Monday, April 04 | 5:00PM - 7:00PM
Novel Approaches and Technology for Early Stage Drug Discove
ry
This session is from Early-Stage Drug Discovery

Room: Ballroom 2

Speaker 2 of 3
Daniel A. Engel, University of Virginia, USA
A General Approach to Novel Drug Target Identification using Budding Yeast


Monday, April 04 | 5:00PM - 7:00PM
Novel Approaches and Technology for Early Stage Drug Discove
ry
This session is from Early-Stage Drug Discovery

Room: Ballroom 2

Speaker 3 of 3
Jolanta Ewa Grembecka, University of Michigan, USA
Short Talk: A Strategy to Develop Potent Inhibitors of Protein-Protein Interaction: Targeting Menin-MLL Interaction in Leukemia


Monday, April 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch/Maybird


Monday, April 04 | 7:30PM - 10:00PM
Poster Session 1
Room: Superior/Superior Lobby/Wasatch/Maybird


Tuesday, April 05 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Tuesday, April 05 | 8:00AM - 11:00AM
Clinical Perspective/Development
Room: Ballroom 3

Speaker 1 of 3
Alexandra R. Lucas, Arizona State University, USA
Viral Bugs Make Great Drugs

Tuesday, April 05 | 8:00AM - 11:00AM
Clinical Perspective/Development
Room: Ballroom 3

Speaker 2 of 3
* Amanda E.I. Proudfoot Fichard, Merck Serono Geneva Research Centre, Switzerland
Parasite Derived Anti-Inflammatory Drugs

Tuesday, April 05 | 8:00AM - 11:00AM
Clinical Perspective/Development
Room: Ballroom 3

Speaker 3 of 3
Wynne Weston-Davies, Varleigh Immuno Pharmaceuticals Ltd., UK, UK
Clinical Trials of Arthropod-Derived Proteins

Tuesday, April 05 | 8:00AM - 11:00AM
Drug Discovery in Academia
This session is from Early-Stage Drug Discovery
Room: Ballroom 2

Speaker 1 of 5
Dennis C. Liotta, Emory University, USA
The Role of CXCR4 Modulators in Controlling HIV Entry, Inflammation and Certain Types of Cancer


Tuesday, April 05 | 8:00AM - 11:00AM
Drug Discovery in Academia
This session is from Early-Stage Drug Discovery
Room: Ballroom 2

Speaker 2 of 5
Jeffrey Jeffrey Conn, Vanderbilt University, USA
Partnering with Big Pharma to Develop mGluR Allosteric Modulators for CNS Disorders: From HTS to Clinical Candidates


Tuesday, April 05 | 8:00AM - 11:00AM
Drug Discovery in Academia
This session is from Early-Stage Drug Discovery
Room: Ballroom 2

Speaker 3 of 5
Julian Blagg, Institute of Cancer Research, UK
Novel Cancer Therapeutics Developed through Academic-Industrial Partnerships


Tuesday, April 05 | 8:00AM - 11:00AM
Drug Discovery in Academia
This session is from Early-Stage Drug Discovery
Room: Ballroom 2

Speaker 4 of 5
Craig W. Lindsley, Vanderbilt University, USA
Allosteric Modulation of Muscarinic Receptors for Treatment of Schizophrenia and Alzheimer's Disease


Tuesday, April 05 | 8:00AM - 11:00AM
Drug Discovery in Academia
This session is from Early-Stage Drug Discovery
Room: Ballroom 2

Speaker 5 of 5
Soumya S. Ray, Schrödinger, USA
Short Talk: Screening and Identification of Small Molecules Against Targets Related to Neurodegenerative Diseases


Tuesday, April 05 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Tuesday, April 05 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Tuesday, April 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch/Maybird


Tuesday, April 05 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Tuesday, April 05 | 5:00PM - 7:00PM
Structure-Function Analysis of Therapeutic Pathogen Molecule
s

Room: Ballroom 3

Speaker 1 of 4
Jos van Strijp, University Medical Center Utrecht, Netherlands
Anti-Inflammatory Drugs from Staphylococcus aureus

Tuesday, April 05 | 5:00PM - 7:00PM
Structure-Function Analysis of Therapeutic Pathogen Molecule
s

Room: Ballroom 3

Speaker 2 of 4
Leah A. Couture, University of Maryland School of Medicine, USA
Short Talk: Identification of Protein-Protein Interfaces Involved in TLR2 and TLR4 Signaling using Cell-Penetrating TIRAP Decoy Peptides

Tuesday, April 05 | 5:00PM - 7:00PM
Structure-Function Analysis of Therapeutic Pathogen Molecule
s

Room: Ballroom 3

Speaker 3 of 4
Tracy M. Handel, University of California, San Diego, USA
Chemokin Structure-Function Mimicy/Exploratory by Virus


Tuesday, April 05 | 5:00PM - 7:00PM
Structure-Function Analysis of Therapeutic Pathogen Molecule
s

Room: Ballroom 3

Speaker 4 of 4
* Daved Fremont, Washington University School of Medicine, USA
Structural Mechanisms of Viral Immune Evasion

Tuesday, April 05 | 5:00PM - 7:00PM
Imaging and Biomarkers in Early Stage Discovery
This session is from Early-Stage Drug Discovery
Room: Ballroom 2

Speaker 1 of 4
Cyrille Sur, Merck Research Laboratories, USA
Small Molecule Biomarkers in Drug Discovery: Optical and PET Imaging
Approaches


Tuesday, April 05 | 5:00PM - 7:00PM
Imaging and Biomarkers in Early Stage Discovery
This session is from Early-Stage Drug Discovery
Room: Ballroom 2

Speaker 2 of 4
Jacob M. Hooker, Harvard Medical School, USA
Advances in Radiotracer Chemistry for Use in Positron Emission Tomography


Tuesday, April 05 | 5:00PM - 7:00PM
Imaging and Biomarkers in Early Stage Discovery
This session is from Early-Stage Drug Discovery
Room: Ballroom 2

Speaker 3 of 4
Javier Sanz, Mount Sinai School of Medicine, USA
New Approaches for Imaging of Atherosclerotic Cardiovascular Disease


Tuesday, April 05 | 5:00PM - 7:00PM
Imaging and Biomarkers in Early Stage Discovery
This session is from Early-Stage Drug Discovery
Room: Ballroom 2

Speaker 4 of 4
Nicholas A. Malmquist, Institut Pasteur, France
Short Talk: Targeting Epigenetic Regulation in the Treatment of Malaria


Tuesday, April 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch/Maybird


Tuesday, April 05 | 7:30PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch/Maybird


Wednesday, April 06 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Wednesday, April 06 | 8:00AM - 11:00AM
Pathogen Modulation of Inflammatory Signaling
Room: Ballroom 3

Speaker 1 of 4
Victor Nizet, University of California, San Diego School of Medicine, USA
Probing Bacterial-Phagocyte Interactions for Novel Infectious Disease (and Anti-Inflammatory?) Therapeutics

Wednesday, April 06 | 8:00AM - 11:00AM
Pathogen Modulation of Inflammatory Signaling
Room: Ballroom 3

Speaker 2 of 4
Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Sensing from Within: Cytosolic Sensing of Microbial Pathogens

Wednesday, April 06 | 8:00AM - 11:00AM
Pathogen Modulation of Inflammatory Signaling
Room: Ballroom 3

Speaker 3 of 4
* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Therapeutic Targeting of Toll-Like Receptors

Wednesday, April 06 | 8:00AM - 11:00AM
Pathogen Modulation of Inflammatory Signaling
Room: Ballroom 3

Speaker 4 of 4
Maria Elena de Lima, Federal University of Minas Gerais, Brazil
Possible Novel Drugs from Arthropod Venoms

Wednesday, April 06 | 8:00AM - 11:00AM
Emerging Targets and Approaches in Drug Discovery
This session is from Early-Stage Drug Discovery
Room: Ballroom 2

Speaker 1 of 4
H. Alex Brown, Vanderbilt University, USA
Phospholipase D: Discovery and Development of Isoform Selective PLD Inhibitors for the Treatment of Cancer


Wednesday, April 06 | 8:00AM - 11:00AM
Emerging Targets and Approaches in Drug Discovery
This session is from Early-Stage Drug Discovery
Room: Ballroom 2

Speaker 2 of 4
Dinah Sah, Voyager Therapeutics, USA
siRNA Therapeutics: Overview and Clinical Trial Update


Wednesday, April 06 | 8:00AM - 11:00AM
Emerging Targets and Approaches in Drug Discovery
This session is from Early-Stage Drug Discovery
Room: Ballroom 2

Speaker 3 of 4
Mark Layton, Merck Research Laboratories, USA
Discovery of Oral Allosteric Akt Kinase Inhibitors for the Treatment of Cancer: MK-2206 and Beyond


Wednesday, April 06 | 8:00AM - 11:00AM
Emerging Targets and Approaches in Drug Discovery
This session is from Early-Stage Drug Discovery
Room: Ballroom 2

Speaker 4 of 4
James A. Wells, University of California, San Francisco, USA
Site-Directed Drug Discovery for Challenging Targets


Wednesday, April 06 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Wednesday, April 06 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Wednesday, April 06 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Wednesday, April 06 | 5:00PM - 7:00PM
Screening Strategies/Technologies- Recent Advances
Room: Ballroom 3

Speaker 1 of 4
* Antonio Alcami, Centro de Biologia Molecular Severo Ochoa, Spain

Wednesday, April 06 | 5:00PM - 7:00PM
Screening Strategies/Technologies- Recent Advances
Room: Ballroom 3

Speaker 2 of 4
Colin Macaulay, Viron Therapeutics Inc., Canada
From Pathogen Immunomodulators to Novel Drugs

Wednesday, April 06 | 5:00PM - 7:00PM
Screening Strategies/Technologies- Recent Advances
Room: Ballroom 3

Speaker 3 of 4
Megan Hogan, U. S. Army Medical Research, USA
Short Talk: Toward the Development of Orthopoxvirus Phosphatase Inhibitors

Wednesday, April 06 | 5:00PM - 7:00PM
Screening Strategies/Technologies- Recent Advances
Room: Ballroom 3

Speaker 4 of 4
Reto Stöcklin, Atheris Laboratories, Switzerland
Venomics: Targeted Drug Discovery and Lead Optimisation using Animal Venoms

Wednesday, April 06 | 5:00PM - 7:00PM
Evolving Role of Big Pharma and Biotech
This session is from Early-Stage Drug Discovery
Room: Ballroom 2

Speaker 1 of 2
Juswinder Singh, Celgene Corporation, USA
Bruton’s Tyrosine Kinase from Bench to Bedside: Covalently Silencing B Cells with AVL-292


Wednesday, April 06 | 5:00PM - 7:00PM
Evolving Role of Big Pharma and Biotech
This session is from Early-Stage Drug Discovery
Room: Ballroom 2

Speaker 2 of 2
Dimitri E. Grigoriadis, Neurocrine Biosciences, Inc., USA
Innovation and the Future of Novel Drug Discovery in Biotech


Wednesday, April 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 1


Wednesday, April 06 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 1


Thursday, April 07 | 10:22AM - 10:22AM
Departure


*Session Chair
†Invited, not yet responded.