Web Desc
Angiogenesis: Advances in Basic Science and Therapeutic Applications
Organizer(s): Napoleone Ferrara, Anne C. Eichmann and Kenneth Walsh
Date: January 16 - 21, 2012
Location: Snowbird Resort, Snowbird, UT, USA
Sponsored by Bayer USA Foundation and Genentech, Inc.
Summary of Meeting:
Much progress has been made in the identification of key signaling pathways regulating blood vessel development. There is also evidence that various stromal cell types participate in normal and pathological angiogenesis in a tissue- or context-specific fashion. However, many important molecular and biological questions regarding these processes remain unanswered. In addition, several angiogenesis inhibitors have been approved by the FDA as therapy for cancer or intraocular neovascular disorders. Perhaps some of the most successful applications of anti-angiogenic therapy are in age-related macular degeneration and other intraocular neovascular diseases, although such findings have been rarely presented outside specialized meetings. The Keystone Symposia meeting on Angiogenesis: Advances in Basic Science and Therapeutic Applications will critically examine the latest basic science on the regulation of angiogenesis in health and disease, discuss the lessons from clinical trials in cancer and intraocular neovascular disorders and identify novel therapeutic targets. Additional discussion will focus on a renewed interest in therapeutic angiogenesis by tissue engineering or stem cell-based approaches.
Scholarship Deadline: September 19 2011
Discounted Abstract Deadline: September 19 2011
Abstract Deadline: October 19 2011
Discounted Registration Deadline: November 16 2011
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bayer USA FoundationGenentech, Inc.
We gratefully acknowledge additional support for this conference from:
American Heart AssociationCell Signaling Technology, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.


Yukio Kato
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL110545-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, January 16 | 3:00PM - 7:30PM
Registration
Room: Ballroom Lobby


Monday, January 16 | 6:15PM - 7:15PM
Refreshments
Room: Ballroom Lobby


Monday, January 16 | 7:15PM - 9:30PM
Welcome and Keynote Session
Room: Ballroom 2-3

Speaker 1 of 2
Kari K. Alitalo, University of Helsinki, Finland
Biological Functions and Therapeutic Potential of Vascular Endothelial Growth Factors

Monday, January 16 | 7:15PM - 9:30PM
Welcome and Keynote Session
Room: Ballroom 2-3

Speaker 2 of 2
Gregg L. Semenza, Johns Hopkins University School of Medicine, USA
Vascular Responses to Ischemia Mediated by Hypoxia-Inducible Factor 1

Tuesday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Superior/Superior Lobby


Tuesday, January 17 | 8:00AM - 11:15AM
Vascular Development
Room: Ballroom 2-3

Speaker 1 of 6
* Anne C. Eichmann, Yale University School of Medicine, USA
Mechanisms of Vascular Patterning

Tuesday, January 17 | 8:00AM - 11:15AM
Vascular Development
Room: Ballroom 2-3

Speaker 2 of 6
Ralf H. Adams, Max Planck Institute for Molecular Biomedicine, Germany
Notch and Ephrin-B2 in Vascular Development

Tuesday, January 17 | 8:00AM - 11:15AM
Vascular Development
Room: Ballroom 2-3

Speaker 3 of 6
Richard A. Lang, Cincinnati Children's Hospital Medical Center, USA
Inhibitory Role of Flt-1 in Development of Retinal Vasculature

Tuesday, January 17 | 8:00AM - 11:15AM
Vascular Development
Room: Ballroom 2-3

Speaker 4 of 6
Konstantin Gaengel, Karolinska Institutet, Sweden
S1P Signaling through S1P1 Controls Vascular Stabilization by Limiting Sprouting Angiogenesis

Tuesday, January 17 | 8:00AM - 11:15AM
Vascular Development
Room: Ballroom 2-3

Speaker 5 of 6
Rong Wang, University of California, San Francisco, USA
Short Talk: Endothelial Notch Signaling Regulates Arterial Venous Programming in Health and Disease

Tuesday, January 17 | 8:00AM - 11:15AM
Vascular Development
Room: Ballroom 2-3

Speaker 6 of 6
Florian P. Limbourg, Medizinische Hochschule Hannover, Germany
Short Talk: Tip Cell Selection by Notch Ligand Delta-Like 1 Regulates Vascular Branching Morphogenesis

Tuesday, January 17 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Tuesday, January 17 | 11:15AM - 1:00PM
Poster Setup
Room: Ballroom 1


Tuesday, January 17 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, January 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom 1


Tuesday, January 17 | 2:30PM - 4:15PM
Workshop 1: Novel Mechanisms / Pathways in Developmental Ang
iogenesis
Room: Ballroom 2-3

Speaker 1 of 8
* Luisa Iruela-Arispe, University of California, Los Angeles, USA

Tuesday, January 17 | 2:30PM - 4:15PM
Workshop 1: Novel Mechanisms / Pathways in Developmental Ang
iogenesis
Room: Ballroom 2-3

Speaker 2 of 8
Karin Albrecht Schgoer, Medical University Hospital Innsbruck, Austria
The Angiogenic Factor Secretoneurin Activates VEGF-Receptors in Coronary Endothelial Cells by Operating as Endogenous Stimulator of VEGF Binding to Heparansulfate Proteoglycans

Tuesday, January 17 | 2:30PM - 4:15PM
Workshop 1: Novel Mechanisms / Pathways in Developmental Ang
iogenesis
Room: Ballroom 2-3

Speaker 3 of 8
Maria Georgiadou, Vesalius Research Center, K.U.Leuven, Belgium
Dll4/Notch Induces Endothelial Cell Quiescence through p53-Mediated Metabolic Reprogramming

Tuesday, January 17 | 2:30PM - 4:15PM
Workshop 1: Novel Mechanisms / Pathways in Developmental Ang
iogenesis
Room: Ballroom 2-3

Speaker 4 of 8
Sophie Paquet-Fifield, Peter MacCallum Cancer Centre, Australia
VEGF-D Modulates Cutaneous Blood Vessels and Lymphatics during Skin Development and Wound Healing

Tuesday, January 17 | 2:30PM - 4:15PM
Workshop 1: Novel Mechanisms / Pathways in Developmental Ang
iogenesis
Room: Ballroom 2-3

Speaker 5 of 8
Ivan B. Lobov, Regeneron Pharmaceuticals, Inc., USA
Effects of Selective or Combined Inhibition of PlGF and VEGF-A on Pathological Neovascularization and Retinal Revascularization in the Murine Model of Oxygen Induced Ischemic Retinopathy (OIR)

Tuesday, January 17 | 2:30PM - 4:15PM
Workshop 1: Novel Mechanisms / Pathways in Developmental Ang
iogenesis
Room: Ballroom 2-3

Speaker 6 of 8
Akiyoshi Uemura, Nagoya City University, Japan
RhoJ Mediates Sema3E-Induced Contraction of Endothelial Cells

Tuesday, January 17 | 2:30PM - 4:15PM
Workshop 1: Novel Mechanisms / Pathways in Developmental Ang
iogenesis
Room: Ballroom 2-3

Speaker 7 of 8
Travis I. Moore, Seoul National University, South Korea
Angiogenesis on a Chip: Microfluidic Platform for Studies in Vessel Morphogenesis, Trans-Endothelium Regulation and High-Throughput Drug Screening

Tuesday, January 17 | 2:30PM - 4:15PM
Workshop 1: Novel Mechanisms / Pathways in Developmental Ang
iogenesis
Room: Ballroom 2-3

Speaker 8 of 8
Jianrong Lu, University of Florida College of Medicine, USA
Restraint of Angiogenesis by CTCF-Mediated Chromatin Insulation

Tuesday, January 17 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Tuesday, January 17 | 5:00PM - 6:50PM
VEGF and VEGF Receptors
Room: Ballroom 2-3

Speaker 1 of 4
* Masabumi Shibuya, University of Tokyo, Japan
Dual Role of VEGFR-1 in Angiogenesis: Its Positive Function in Carcinogenesis

Tuesday, January 17 | 5:00PM - 6:50PM
VEGF and VEGF Receptors
Room: Ballroom 2-3

Speaker 2 of 4
Luisa Iruela-Arispe, University of California, Los Angeles, USA
Ins and Outs of VEGFR2

Tuesday, January 17 | 5:00PM - 6:50PM
VEGF and VEGF Receptors
Room: Ballroom 2-3

Speaker 3 of 4
Eli Keshet, Hebrew University, Israel
'Non-Traditional' Functions of VEGF and the Vasculature

Tuesday, January 17 | 5:00PM - 6:50PM
VEGF and VEGF Receptors
Room: Ballroom 2-3

Speaker 4 of 4
Michael E. Boulton, University of Florida, USA
Short Talk: Secretase-Dependent Cleavage of VEGFR1 Regulates VEGF-Induced Angiogenesis

Tuesday, January 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 1


Tuesday, January 17 | 7:30PM - 10:00PM
Poster Session 1
Room: Ballroom 1


Wednesday, January 18 | 7:00AM - 8:00AM
Breakfast
Room: Superior/Superior Lobby


Wednesday, January 18 | 8:00AM - 11:05AM
Role of Inflammation in Tumor Angiogenesis/Lymphangiogenesis
Room: Ballroom 2-3

Speaker 1 of 5
* Amato J. Giaccia, Stanford University, USA
Hypoxia and Cancer

Wednesday, January 18 | 8:00AM - 11:05AM
Role of Inflammation in Tumor Angiogenesis/Lymphangiogenesis
Room: Ballroom 2-3

Speaker 2 of 5
Tatiana V. Byzova, Cleveland Clinic Foundation, USA
TLR2 and Angiogenesis

Wednesday, January 18 | 8:00AM - 11:05AM
Role of Inflammation in Tumor Angiogenesis/Lymphangiogenesis
Room: Ballroom 2-3

Speaker 3 of 5
Roberta Mazzieri, San Raffaele Telethon Institute for, Italy
Macrophage Regulation of Tumor Angiogenesis

Wednesday, January 18 | 8:00AM - 11:05AM
Role of Inflammation in Tumor Angiogenesis/Lymphangiogenesis
Room: Ballroom 2-3

Speaker 4 of 5
Viviane Tabar, Memorial Sloan Kettering Cancer Center, USA
Cancer Stem Cells and Angiogenesis

Wednesday, January 18 | 8:00AM - 11:05AM
Role of Inflammation in Tumor Angiogenesis/Lymphangiogenesis
Room: Ballroom 2-3

Speaker 5 of 5
Lee M. Ellis, University of Texas MD Anderson Cancer Center, USA
Angiocrine Signaling and Induction of the Cancer Stem Cell Phenotype

Wednesday, January 18 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Wednesday, January 18 | 11:15AM - 1:00PM
Poster Setup
Room: Ballroom 1


Wednesday, January 18 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, January 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom 1


Wednesday, January 18 | 2:30PM - 4:30PM
Workshop 2: New Mechanisms and Therapeutic Targets for Tumor
Angiogenesis
Room: Ballroom 2-3

Speaker 1 of 7
* Robert S. Kerbel, Sunnybrook Research Institute, Canada

Wednesday, January 18 | 2:30PM - 4:30PM
Workshop 2: New Mechanisms and Therapeutic Targets for Tumor
Angiogenesis
Room: Ballroom 2-3

Speaker 2 of 7
Christian Kupatt, Technical University Munich, Germany
Angiopoietin-2-Induced Pericyte Loss Partially Mediates Systemic Inflammatory Response Syndrome (SIRS)

Wednesday, January 18 | 2:30PM - 4:30PM
Workshop 2: New Mechanisms and Therapeutic Targets for Tumor
Angiogenesis
Room: Ballroom 2-3

Speaker 3 of 7
David O. Bates, Queen's Medical Centre, UK
SRPK1 Is a Novel Angiogenesis Target through Alteration of VEGF Splicing

Wednesday, January 18 | 2:30PM - 4:30PM
Workshop 2: New Mechanisms and Therapeutic Targets for Tumor
Angiogenesis
Room: Ballroom 2-3

Speaker 4 of 7
Mikhail G. Kolonin, University of Texas Health Sciences Center, USA
Pro-Angiogenic Adipocyte Progenitors Contribute to Obesity-Associated Cancer Progression

Wednesday, January 18 | 2:30PM - 4:30PM
Workshop 2: New Mechanisms and Therapeutic Targets for Tumor
Angiogenesis
Room: Ballroom 2-3

Speaker 5 of 7
Anja C. Runge, German Cancer Research Center, Germany
Hepatocellular Carcinoma Angiogenesis Utilizing a Novel Conditional Model of Multi-Stage Liver Tumor Progression

Wednesday, January 18 | 2:30PM - 4:30PM
Workshop 2: New Mechanisms and Therapeutic Targets for Tumor
Angiogenesis
Room: Ballroom 2-3

Speaker 6 of 7
Mark Thomas Uhlik, Eli Lilly and Company, USA
Discovering a Novel Anti-Angiogenesis Inhibitor, from 'Phenotypic' to 'Mechanistic'

Wednesday, January 18 | 2:30PM - 4:30PM
Workshop 2: New Mechanisms and Therapeutic Targets for Tumor
Angiogenesis
Room: Ballroom 2-3

Speaker 7 of 7
Tsuyoshi Osawa, University of Tokyo, Japan
Inhibition of Histone Demethylase JHDM2A Expressed under Hypoxia and Nutrient Starvation Suppresses Tumor Growth and Enhances Anti-Angiogenic Therapy

Wednesday, January 18 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Wednesday, January 18 | 5:00PM - 7:00PM
Tumor Angiogenesis and Translational Studies
Room: Ballroom 2-3

Speaker 1 of 4
* David A. Cheresh, University of California, San Diego, USA
A MEK-Independent Role for CRAF in Mitosis, Angiogenesis and Tumor Progression

Wednesday, January 18 | 5:00PM - 7:00PM
Tumor Angiogenesis and Translational Studies
Room: Ballroom 2-3

Speaker 2 of 4
Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA
Cancer Cell Autonomous Changes Cooperate with Stromal Changes to Facilitate Cancer Progression and Metastasis

Wednesday, January 18 | 5:00PM - 7:00PM
Tumor Angiogenesis and Translational Studies
Room: Ballroom 2-3

Speaker 3 of 4
Gou Young Koh, Institute of Basic Science, South Korea
Targeting Angiopoietin-2 and VEGF-A for Anti-Angiogenesis and Anti-Vascular Leakage

Wednesday, January 18 | 5:00PM - 7:00PM
Tumor Angiogenesis and Translational Studies
Room: Ballroom 2-3

Speaker 4 of 4
Mallika Singh, REVOLUTION Medicines, USA
Short Talk: Anti-VEGF Monoclonal Antibody Therapy in Genetically Engineered Mouse Tumor Models: Efficacy, Survival and Metastasis

Wednesday, January 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 1


Wednesday, January 18 | 7:30PM - 10:00PM
Poster Session 2
Room: Ballroom 1


Thursday, January 19 | 7:00AM - 8:00AM
Breakfast
Room: Superior/Superior Lobby


Thursday, January 19 | 8:00AM - 11:00AM
Metabolism, Hypoxia and Angiogenesis
Room: Ballroom 2-3

Speaker 1 of 4
* M. Celeste Simon, University of Pennsylvania, USA
Hypoxia and Angiogenesis

Thursday, January 19 | 8:00AM - 11:00AM
Metabolism, Hypoxia and Angiogenesis
Room: Ballroom 2-3

Speaker 2 of 4
Peter F. Carmeliet, University of Leuven, VIB, Belgium
Metabolism: A Target in Angiogenesis

Thursday, January 19 | 8:00AM - 11:00AM
Metabolism, Hypoxia and Angiogenesis
Room: Ballroom 2-3

Speaker 3 of 4
Ulf P.E. Eriksson, Karolinska Institutet, Sweden
Role of VEGF-B in Lipid and Glucose Metabolism

Thursday, January 19 | 8:00AM - 11:00AM
Metabolism, Hypoxia and Angiogenesis
Room: Ballroom 2-3

Speaker 4 of 4
Masataka Majima, Kitasato University School of Medicine, Japan
Roles of Prostaglandins in Enhancement of Angiogenesis and Lymphangiogenesis in Pathological Conditions

Thursday, January 19 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Thursday, January 19 | 11:00AM - 1:00PM
Poster Setup
Room: Ballroom 1


Thursday, January 19 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Thursday, January 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom 1


Thursday, January 19 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Thursday, January 19 | 5:00PM - 7:00PM
Ocular Angiogenesis
Room: Ballroom 2-3

Speaker 1 of 5
* Michael E. Boulton, University of Florida, USA

Thursday, January 19 | 5:00PM - 7:00PM
Ocular Angiogenesis
Room: Ballroom 2-3

Speaker 2 of 5
Jayakrishna Ambati, University of Kentucky College of Medicine, USA
CCR3 in Choroidal Neovascularization

Thursday, January 19 | 5:00PM - 7:00PM
Ocular Angiogenesis
Room: Ballroom 2-3

Speaker 3 of 5
Eric Ng, University College London, UK
Model Systems for Studying Vascular Growth and Barrier Function

Thursday, January 19 | 5:00PM - 7:00PM
Ocular Angiogenesis
Room: Ballroom 2-3

Speaker 4 of 5
Weilan Ye, Genentech, Inc., USA
Subtype Specification and Patterning of the Retinal Vasculature

Thursday, January 19 | 5:00PM - 7:00PM
Ocular Angiogenesis
Room: Ballroom 2-3

Speaker 5 of 5
Chatarina A. Löfqvist, Harvard Medical School, USA
Short Talk: Adiponectin May Play a Role in Retinopathy of Prematurity

Thursday, January 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 1


Thursday, January 19 | 7:30PM - 10:00PM
Poster Session 3
Room: Ballroom 1


Friday, January 20 | 7:00AM - 8:00AM
Breakfast
Room: Superior/Superior Lobby


Friday, January 20 | 8:00AM - 11:00AM
Anti-Angiogenesis: Insights from Clinical Trials
Room: Ballroom 2-3

Speaker 1 of 5
* Napoleone Ferrara, University of California, San Diego, USA
Tumor Microenvironment and VEGF-Independent Angiogenesis

Friday, January 20 | 8:00AM - 11:00AM
Anti-Angiogenesis: Insights from Clinical Trials
Room: Ballroom 2-3

Speaker 2 of 5
Robert S. Kerbel, Sunnybrook Research Institute, Canada
Preclinical Translational Approach to Improving the Predictive Potential of Anti-Angiogenic Treatments for Early or Late Stage Metastatic Disease

Friday, January 20 | 8:00AM - 11:00AM
Anti-Angiogenesis: Insights from Clinical Trials
Room: Ballroom 2-3

Speaker 3 of 5
Brian I. Rini, Cleveland Clinc, USA
Anti-Angiogenic Therapy in the Clinic: Where We are, Where We Are Going and How We Will Get There

Friday, January 20 | 8:00AM - 11:00AM
Anti-Angiogenesis: Insights from Clinical Trials
Room: Ballroom 2-3

Speaker 4 of 5
Aarif Y. Khakoo, Amgen, USA
Short Talk: Exploration of Cardiotoxicity due to Sunitinib Reveals a Novel Role for Microvascular Pericytes in the Heart

Friday, January 20 | 8:00AM - 11:00AM
Anti-Angiogenesis: Insights from Clinical Trials
Room: Ballroom 2-3

Speaker 5 of 5
Anna I. Dimberg, Uppsala University Hospital, Sweden
Short Talk: Distinct Gene Expression Signature of Vessels in Human Glioblastoma

Friday, January 20 | 9:00AM - 9:20AM
Coffee Break
Room: Ballroom Lobby


Friday, January 20 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Friday, January 20 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Friday, January 20 | 5:00PM - 7:00PM
Therapeutic Angiogenesis
Room: Ballroom 2-3

Speaker 1 of 4
* Kenneth Walsh, University of Virginia School of Medicine, USA
Mechanisms That Coordinate Angiogenesis with Physiological Tissue Growth

Friday, January 20 | 5:00PM - 7:00PM
Therapeutic Angiogenesis
Room: Ballroom 2-3

Speaker 2 of 4
Shahin Rafii, Weill Cornell Medical College, USA
Vascular Niche-Derived Angiocrine Factors Initiate and Sustain Organ Regeneration

Friday, January 20 | 5:00PM - 7:00PM
Therapeutic Angiogenesis
Room: Ballroom 2-3

Speaker 3 of 4
William C. Sessa, Yale University School of Medicine, USA
MicroRNA/Therapeutic Angiogenesis

Friday, January 20 | 5:00PM - 7:00PM
Therapeutic Angiogenesis
Room: Ballroom 2-3

Speaker 4 of 4
Puneet Opal, Northwestern University, USA
Short Talk: VEGF Ameliorates the Ataxic Phenotype in Spinocerebellar Ataxia Type 1 (SCA1) Mice

Friday, January 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 1-2


Friday, January 20 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 1-2


Friday, January 20 | 8:00PM - 11:00PM
Cash Bar
Room: Ballroom 1-2


Saturday, January 21 | 10:25AM - 10:25AM
Departure


*Session Chair.