Web Desc
Rheumatoid Arthritis: Molecular and Clinical Insights
Organizer(s): David M. Lee, Gary S. Firestein and Ellen M. Gravallese
Date: January 19 - 24, 2012
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Organized with the support of the American College of Rheumatology Research and Education Foundation
Summary of Meeting:
Recent advances in genetic, cellular and molecular methodologies provide both new insights into disease pathogenesis and opportunities for therapeutic advances. Despite broad interest in rheumatoid arthritis (RA) within the immunology and clinical communities, there exists no focused venue for investigators with an interest in this disease to interact with each other, sharing ideas and developing productive collaborations. The Keystone Symposia format will fill this burgeoning need. This meeting will provide a venue for discussion of cutting-edge research topics in basic science and clinical science areas relevant to RA research. By fostering interactions between basic, translational and clinical investigators, we anticipate that this meeting will lead to new studies – as well as new approaches to studying – the pathogenesis and treatment of RA. The meeting will also serve to promote scientific development of early-career investigators, including those in training; their work will be among the selected presentations, creating an opportunity for interaction between junior investigators and outstanding senior scientists and mentors.
Scholarship Deadline: September 21 2011
Discounted Abstract Deadline: September 21 2011
Abstract Deadline: October 24 2011
Discounted Registration Deadline: November 21 2011
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
American College of Rheumatology Research and Education Foundation
We gratefully acknowledge additional support for this conference from:
Rigel Pharmaceuticals, Inc.Takeda California
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.

Novartis Pharma AG
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
The Journal of Rheumatology
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Grant No. 1R13AR061874-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, January 19 | 3:00PM - 7:30PM
Registration
Room: Zia Concourse


Thursday, January 19 | 6:15PM - 7:15PM
Refreshments
Room: Zia Concourse


Thursday, January 19 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Anasazi Ballroom

Speaker 1 of 4
David M. Lee, Janssen Pharmaceutical Companies of Johnson & Johnson, USA
Introductory Remarks

Thursday, January 19 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Anasazi Ballroom

Speaker 2 of 4
Gary S. Firestein, University of California, San Diego, USA
Moving the Field Forward: RA Research and Impact on Disease

Thursday, January 19 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Anasazi Ballroom

Speaker 3 of 4
* Ellen M. Gravallese, University of Massachusetts Medical School, USA
Introduction of Keynote Speaker

Thursday, January 19 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Anasazi Ballroom

Speaker 4 of 4
William P. Arend, University of Colorado School of Medicine, USA
Disease Mechanisms and Treatments: A Historic Benchtop to Bedside Perspective

Friday, January 20 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Friday, January 20 | 8:00AM - 11:00AM
Integrated Biology of the Joint in Rheumatoid Arthritis
Room: Anasazi Ballroom

Speaker 1 of 6
* Alisa Koch, University of Michigan, USA

Friday, January 20 | 8:00AM - 11:00AM
Integrated Biology of the Joint in Rheumatoid Arthritis
Room: Anasazi Ballroom

Speaker 2 of 6
* William F. Rigby, Dartmouth Medical School, USA

Friday, January 20 | 8:00AM - 11:00AM
Integrated Biology of the Joint in Rheumatoid Arthritis
Room: Anasazi Ballroom

Speaker 3 of 6
Michael B. Brenner, Harvard Medical School, USA
Cadherin-11 Modulates Synovial Fibroblast Inflammation and Degradation

Friday, January 20 | 8:00AM - 11:00AM
Integrated Biology of the Joint in Rheumatoid Arthritis
Room: Anasazi Ballroom

Speaker 4 of 6
Gary S. Firestein, University of California, San Diego, USA
Signaling Mechanisms in Synovial Inflammation

Friday, January 20 | 8:00AM - 11:00AM
Integrated Biology of the Joint in Rheumatoid Arthritis
Room: Anasazi Ballroom

Speaker 5 of 6
Ellen M. Gravallese, University of Massachusetts Medical School, USA
Osteoclasts and Osteoblasts in Rheumatoid Arthritis

Friday, January 20 | 8:00AM - 11:00AM
Integrated Biology of the Joint in Rheumatoid Arthritis
Room: Anasazi Ballroom

Speaker 6 of 6
Georg Schett, University of Erlangen-Nuremberg, Germany
Osteoimmunology: Cells and Factors that Impact Bone

Friday, January 20 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Friday, January 20 | 11:00AM - 1:00PM
Poster Setup
Room: Sunset Room


Friday, January 20 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Friday, January 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room


Friday, January 20 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Friday, January 20 | 5:00PM - 7:15PM
Innate Immunity in Rheumatoid Arthritis
Room: Anasazi Ballroom

Speaker 1 of 5
* Maripat P. Corr, University of California, San Diego, USA

Friday, January 20 | 5:00PM - 7:15PM
Innate Immunity in Rheumatoid Arthritis
Room: Anasazi Ballroom

Speaker 2 of 5
Nina Bhardwaj, Icahn School of Medicine at Mount Sinai, USA
Dendritic Cell-Mediated Modulation of Treg Function

Friday, January 20 | 5:00PM - 7:15PM
Innate Immunity in Rheumatoid Arthritis
Room: Anasazi Ballroom

Speaker 3 of 5
Peter A. Nigrovic, Brigham and Women's Hospital, USA
Mast Cells in Arthritis: If, When and How

Friday, January 20 | 5:00PM - 7:15PM
Innate Immunity in Rheumatoid Arthritis
Room: Anasazi Ballroom

Speaker 4 of 5
David M. Lee, Janssen Pharmaceutical Companies of Johnson & Johnson, USA
Platelets, Microvesicles and Inflammatory Synovitis

Friday, January 20 | 5:00PM - 7:15PM
Innate Immunity in Rheumatoid Arthritis
Room: Anasazi Ballroom

Speaker 5 of 5
Steffen Gay, University Hospital Zürich, Switzerland
Epigenetics, microRNA and Innate Immunity

Friday, January 20 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Friday, January 20 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunset Room


Saturday, January 21 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Saturday, January 21 | 8:00AM - 11:15AM
Autoimmunity I
Room: Anasazi Ballroom

Speaker 1 of 8
* S. Louis Bridges, Jr., University of Alabama, Birmingham, USA

Saturday, January 21 | 8:00AM - 11:15AM
Autoimmunity I
Room: Anasazi Ballroom

Speaker 2 of 8
* Robert H. Carter, NIAMS, National Institutes of Health, USA

Saturday, January 21 | 8:00AM - 11:15AM
Autoimmunity I
Room: Anasazi Ballroom

Speaker 3 of 8
Jennifer H. Anolik, University of Rochester, USA
Autoantibody Dependent vs. Independent Roles for B Cells in RA

Saturday, January 21 | 8:00AM - 11:15AM
Autoimmunity I
Room: Anasazi Ballroom

Speaker 4 of 8
Gregg J. Silverman, New York University Langone Medical Center, USA
Pathogenic and Protective Autoantibodies in Inflammatory Synovitis

Saturday, January 21 | 8:00AM - 11:15AM
Autoimmunity I
Room: Anasazi Ballroom

Speaker 5 of 8
Andrew C. Chan, Genentech, Inc., USA
Redefining Human Disease to Meet the Challenges of Drug Discovery and Clinical Practice

Saturday, January 21 | 8:00AM - 11:15AM
Autoimmunity I
Room: Anasazi Ballroom

Speaker 6 of 8
David G. Winkler, Infinity Pharmaceuticals, Inc., USA
Taking PI3Kdelta and PI3Kgamma for the Treatment of Immune-Mediated Inflammatory Diseases

Saturday, January 21 | 8:00AM - 11:15AM
Autoimmunity I
Room: Anasazi Ballroom

Speaker 7 of 8
Narendiran Rajasekaran, Stanford University, USA
Short Talk: Host-Derived CD4+ T Cells Protect Lethally Irradiated B6.g7 Mice from Stem Cell Mediated Transfer of Autoimmunity

Saturday, January 21 | 8:00AM - 11:15AM
Autoimmunity I
Room: Anasazi Ballroom

Speaker 8 of 8
Safiehkhatoon Moshkani, University of Rochester, USA
Short Talk: CD23+CD21High B Cells in Inflamed Lymph Nodes of TNF-Transgenic Mice Are a Locally Differentiated Population with Increased Antigen Capture and Activation Potential

Saturday, January 21 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Saturday, January 21 | 11:15AM - 1:00PM
Poster Setup
Room: Sunset Room


Saturday, January 21 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Saturday, January 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room


Saturday, January 21 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Saturday, January 21 | 5:00PM - 7:00PM
Systemic Disease in Rheumatoid Arthritis
Room: Anasazi Ballroom

Speaker 1 of 4
* William P. Arend, University of Colorado School of Medicine, USA

Saturday, January 21 | 5:00PM - 7:00PM
Systemic Disease in Rheumatoid Arthritis
Room: Anasazi Ballroom

Speaker 2 of 4
Camilla I. Svensson, Karolinska Institutet, Sweden
How Inflammatory Synovitis Produces Persistent Pain

Saturday, January 21 | 5:00PM - 7:00PM
Systemic Disease in Rheumatoid Arthritis
Room: Anasazi Ballroom

Speaker 3 of 4
Kevin L. Winthrop, Oregon Health & Science University, USA
Anti-TNF Therapy and Beyond: Serious Infections and Mechanisms of Suppressed Host Defense in RA

Saturday, January 21 | 5:00PM - 7:00PM
Systemic Disease in Rheumatoid Arthritis
Room: Anasazi Ballroom

Speaker 4 of 4
Joan M. Bathon, Columbia University, USA
Accelerated Atherosclerosis and Cardiovascular Disease

Saturday, January 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Saturday, January 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Sunset Room


Sunday, January 22 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Sunday, January 22 | 8:00AM - 11:15AM
Autoimmunity II
Room: Anasazi Ballroom

Speaker 1 of 8
* Hani El-Gabalawy, University of Manitoba, Canada

Sunday, January 22 | 8:00AM - 11:15AM
Autoimmunity II
Room: Anasazi Ballroom

Speaker 2 of 8
* Soumya Raychaudhuri, Brigham and Women's Hospital, Harvard Medical School, USA

Sunday, January 22 | 8:00AM - 11:15AM
Autoimmunity II
Room: Anasazi Ballroom

Speaker 3 of 8
Dhavalkumar D. Patel, UCB S.A., Belgium
Role of IL-17A in Rheumatoid Arthritis and Other Autoimmune Diseases.

Sunday, January 22 | 8:00AM - 11:15AM
Autoimmunity II
Room: Anasazi Ballroom

Speaker 4 of 8
V. Michael Holers, University of Colorado Denver, USA
When Does RA Begin: Inflammatory and Autoimmune Signatures Precede Clinical Onset

Sunday, January 22 | 8:00AM - 11:15AM
Autoimmunity II
Room: Anasazi Ballroom

Speaker 5 of 8
David A. Fox, University of Michigan Medical School, USA
Pathogenic and Protective T Cell Subsets in Rheumatoid Arthritis

Sunday, January 22 | 8:00AM - 11:15AM
Autoimmunity II
Room: Anasazi Ballroom

Speaker 6 of 8
William H. Robinson, Stanford University School of Medicine, USA
Citrullination of Fibrinogen: Generation of Neoepitopes and Enhancement of Immunostimulatory Properties

Sunday, January 22 | 8:00AM - 11:15AM
Autoimmunity II
Room: Anasazi Ballroom

Speaker 7 of 8
Eric Boilard, CRCHUQ, Universite Laval, Canada
Short Talk: Novel Platelet Function during Inflammatory Arthritis

Sunday, January 22 | 8:00AM - 11:15AM
Autoimmunity II
Room: Anasazi Ballroom

Speaker 8 of 8
Khaled Amara, Karolinska Institutet, Sweden
Short Talk: Generation and Characterization of Monoclonal Antibodies from Single RA Synovial B Cells

Sunday, January 22 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Sunday, January 22 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Sunday, January 22 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Sunday, January 22 | 5:00PM - 7:00PM
Imaging and Biomarkers
Room: Anasazi Ballroom

Speaker 1 of 4
* Ingrid E. Lundberg, Karolinska Institutet, Sweden

Sunday, January 22 | 5:00PM - 7:00PM
Imaging and Biomarkers
Room: Anasazi Ballroom

Speaker 2 of 4
Dennis McGonagle, University of Leeds, St. James’s University Hospital, UK
From Pathogenesis to Disease Remission-How MRI and Ultrasound Have Transformed the Understanding of RA

Sunday, January 22 | 5:00PM - 7:00PM
Imaging and Biomarkers
Room: Anasazi Ballroom

Speaker 3 of 4
Michael L. Dustin, University of Oxford, UK
In vivo Tracking of Regulatory T Cell Dynamics in Models of Autoimmune Disease

Sunday, January 22 | 5:00PM - 7:00PM
Imaging and Biomarkers
Room: Anasazi Ballroom

Speaker 4 of 4
Michael Centola, Oklahoma Medical Research Foundation, USA
Utilizing Biomarkers of RA Disease Activity to Identify Patients at Risk of Joint Damage

Sunday, January 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Monday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Monday, January 23 | 8:00AM - 11:15AM
Omics and Informatics
Room: Anasazi Ballroom

Speaker 1 of 7
* David R. Karp, University of Texas Southwestern Medical Center, USA

Monday, January 23 | 8:00AM - 11:15AM
Omics and Informatics
Room: Anasazi Ballroom

Speaker 2 of 7
* Erik J. Peterson, University of Minnesota, USA

Monday, January 23 | 8:00AM - 11:15AM
Omics and Informatics
Room: Anasazi Ballroom

Speaker 3 of 7
Iain B. McInnes, University of Glasgow, UK
Therapeutic Opportunities in Innate Immunity in Inflammatory Arthritis

Monday, January 23 | 8:00AM - 11:15AM
Omics and Informatics
Room: Anasazi Ballroom

Speaker 4 of 7
Soumya Raychaudhuri, Brigham and Women's Hospital, Harvard Medical School, USA
Translating Rheumatoid Arthritis Genetic Loci into Pathogenic Processes

Monday, January 23 | 8:00AM - 11:15AM
Omics and Informatics
Room: Anasazi Ballroom

Speaker 5 of 7
Lars Klareskog, Karolinska Institutet, Sweden
Susceptibility Is More Than Our Genes: Roles of Environment and Genes in Triggering Disease-Related Autoimmunity

Monday, January 23 | 8:00AM - 11:15AM
Omics and Informatics
Room: Anasazi Ballroom

Speaker 6 of 7
Robert M. Plenge, Celgene, USA
'The Cycle' of Discovery Research in Rheumatoid Arthritis: Integrating Next-Generation Genomics with Next-Generation Clinical Data from Electronic Health Records

Monday, January 23 | 8:00AM - 11:15AM
Omics and Informatics
Room: Anasazi Ballroom

Speaker 7 of 7
Ronald N. Germain, NIAID, National Institutes of Health, USA
A New Omics: System-Wide Analysis of the Human Immune System in Health and Disease

Monday, January 23 | 9:00AM - 9:20AM
Coffee Break
Room: Zia Concourse


Monday, January 23 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Monday, January 23 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Monday, January 23 | 5:00PM - 7:00PM
Clinical Developments in Rheumatoid Arthritis
Room: Anasazi Ballroom

Speaker 1 of 4
Michael J. Townsend, Genentech, Inc, USA
Short Talk: Rheumatoid Arthritis Patients Possess Distinct Molecular and Cellular Synovial Phenotypes that Impact Clinical Outcome

Monday, January 23 | 5:00PM - 7:00PM
Clinical Developments in Rheumatoid Arthritis
Room: Anasazi Ballroom

Speaker 2 of 4
Cécile T. J. Holweg, Genentech, Inc., USA
Short Talk: Pretreatment Synovial Transcriptional Profile Correlates with Early and Late Clinical Response in Rheumatoid Arthritis Patients Treated with Rituximab

Monday, January 23 | 5:00PM - 7:00PM
Clinical Developments in Rheumatoid Arthritis
Room: Anasazi Ballroom

Speaker 3 of 4
Eric M. Ruderman, Northwestern University, USA
Placebos, Active Comparators and Creative Trial Design in RA

Monday, January 23 | 5:00PM - 7:00PM
Clinical Developments in Rheumatoid Arthritis
Room: Anasazi Ballroom

Speaker 4 of 4
* E. William St. Clair, Duke University Medical Center, USA
Therapeutic Targeting of Adaptive Immunity in Rheumatoid Arthritis: Successes and Limitations

Monday, January 23 | 7:00PM - 7:05PM
Closing Remarks
Room: Anasazi Ballroom

Speaker 1 of 3
David M. Lee, Janssen Pharmaceutical Companies of Johnson & Johnson, USA

Monday, January 23 | 7:00PM - 7:05PM
Closing Remarks
Room: Anasazi Ballroom

Speaker 2 of 3
Gary S. Firestein, University of California, San Diego, USA

Monday, January 23 | 7:00PM - 7:05PM
Closing Remarks
Room: Anasazi Ballroom

Speaker 3 of 3
Ellen M. Gravallese, University of Massachusetts Medical School, USA

Monday, January 23 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Monday, January 23 | 8:00PM - 11:00PM
Entertainment
Room: Eldorado Court/Sunset Room


Monday, January 23 | 8:00PM - 11:00PM
Cash Bar
Room: Eldorado Court/Sunset Room


Tuesday, January 24 | 10:25AM - 10:25AM
Departure


*Session Chair.