Web Desc
Membranes in Motion
Organizer(s): Harvey T. McMahon and Jodi Nunnari
Date: January 22 - 27, 2012
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Supported by the Directors' Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Membranes allow for the compartmentalization of many different processes in the cell, thus allowing for organizational complexity. Membranes are now known to be direct players in cell physiology, including organelle structure and biogenesis, membrane transport and intracellular trafficking, as well as in dysfunctions leading to disease such as Huntington’s disease, chronic inflammation, viral infections and metastatic cell invasion. This symposium will cover emerging topics in membrane trafficking and disease. It will highlight progress in membrane fusion, fission and budding mechanisms as well as the recent expansion of endocytic pathways and their coupling to signaling. There will be an emphasis on the fundamental importance of controlling membrane curvature, beyond its role in shaping organelles looking forward to direct functions in organelle dynamics and organization. This symposium seeks to bring together those at the forefront of different disciplines to address current issues in membrane biology. The overlapping topics should stimulate discussion and cross-fertilization.
Scholarship Deadline: September 21 2011
Discounted Abstract Deadline: September 21 2011
Abstract Deadline: October 24 2011
Discounted Registration Deadline: November 21 2011
We gratefully acknowledge additional support for this conference from:
Avanti Polar Lipids, Inc.Landes Bioscience
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Sunday, January 22 | 3:00PM - 7:30PM
Registration
Room: Pre Function


Sunday, January 22 | 6:15PM - 7:15PM
Buffet Dinner
Room: Granhall


Sunday, January 22 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Mountain/Lake

Speaker 1 of 1
Tom A. Rapoport, Harvard University Medical School, USA
How the Endoplasmic Reticulum Gets into Shape

Monday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, January 23 | 8:00AM - 11:15AM
Disease States and Membrane Trafficking Mechanisms I
Room: Mountain/Lake

Speaker 1 of 7
* Joshua Zimmerberg, NICHD, National Institutes of Health, USA

Monday, January 23 | 8:00AM - 11:15AM
Disease States and Membrane Trafficking Mechanisms I
Room: Mountain/Lake

Speaker 2 of 7
Ari Helenius, ETH Zurich, Switzerland
Viruses, Caveolae, and Endosomes: Confining Caveolae to the Plasma Membrane

Monday, January 23 | 8:00AM - 11:15AM
Disease States and Membrane Trafficking Mechanisms I
Room: Mountain/Lake

Speaker 3 of 7
Chiara Zurzolo, Institut Pasteur, France
Role of Tunneling Nanotubes (TNTs) in Prion Intercellular Spreading

Monday, January 23 | 8:00AM - 11:15AM
Disease States and Membrane Trafficking Mechanisms I
Room: Mountain/Lake

Speaker 4 of 7
Jocelyn Laporte, Institute of Genetics and Molecular and Cellular Biology, France
Short Talk: Dynamin 2 in Skeletal Muscle Development and Diseases

Monday, January 23 | 8:00AM - 11:15AM
Disease States and Membrane Trafficking Mechanisms I
Room: Mountain/Lake

Speaker 5 of 7
Ron R. Kopito, Stanford University, USA
Prion-Like Intercellular Transmission of Protein Aggregates in Neurodegenerative Disease

Monday, January 23 | 8:00AM - 11:15AM
Disease States and Membrane Trafficking Mechanisms I
Room: Mountain/Lake

Speaker 6 of 7
Pascale Cossart, Institut Pasteur, France
Pathogenic Bacteria and Membrane Trafficking

Monday, January 23 | 8:00AM - 11:15AM
Disease States and Membrane Trafficking Mechanisms I
Room: Mountain/Lake

Speaker 7 of 7
Daniel Humphreys, Cambridge University, UK
Short Talk: WAVE is Activated by Cooperating Arf and Rac1 GTPases, and Targeted by Pathogen and Host GEFs during Invasion

Monday, January 23 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Monday, January 23 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Monday, January 23 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, January 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Monday, January 23 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Monday, January 23 | 5:00PM - 7:00PM
Disease States and Membrane Trafficking Mechanisms II
Room: Mountain/Lake

Speaker 1 of 5
* Thomas Langer, CECAD Research Center, Germany

Monday, January 23 | 5:00PM - 7:00PM
Disease States and Membrane Trafficking Mechanisms II
Room: Mountain/Lake

Speaker 2 of 5
Thomas J. Jentsch, Max-Delbrück-Center for Molecular Medicine (MDC), Germany
The Need for H+-Driven Vesicular Cl- Accumulation: Insights from Human Disease, Mice and Biophysics

Monday, January 23 | 5:00PM - 7:00PM
Disease States and Membrane Trafficking Mechanisms II
Room: Mountain/Lake

Speaker 3 of 5
Ira Mellman, Genentech, Inc., USA
Cancer and Membrane Trafficking

Monday, January 23 | 5:00PM - 7:00PM
Disease States and Membrane Trafficking Mechanisms II
Room: Mountain/Lake

Speaker 4 of 5
Emmanuel Boucrot, MRC Laboratory of Molecular Biology, UK
Short Talk:

Monday, January 23 | 5:00PM - 7:00PM
Disease States and Membrane Trafficking Mechanisms II
Room: Mountain/Lake

Speaker 5 of 5
Miguel A. del Pozo, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain
Short Talk: Caveolin-1 in Membrane Trafficking and Biomechanical Remodeling of the Tumor Microenvironment

Monday, January 23 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Monday, January 23 | 8:00PM - 10:00PM
Poster Session 1
Room: Bay


Monday, January 23 | 8:00PM - 9:00PM
Social Hour
Room: Bay


Tuesday, January 24 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, January 24 | 8:00AM - 11:15AM
Clathrin-Dependent Endocytosis
Room: Mountain/Lake

Speaker 1 of 7
* Satyajit Mayor, National Centre for Biological Sciences, India

Tuesday, January 24 | 8:00AM - 11:15AM
Clathrin-Dependent Endocytosis
Room: Mountain/Lake

Speaker 2 of 7
Tom Kirchhausen, Harvard Medical School, USA
Dynamics of Endocytosis

Tuesday, January 24 | 8:00AM - 11:15AM
Clathrin-Dependent Endocytosis
Room: Mountain/Lake

Speaker 3 of 7
Pietro V. De Camilli, Yale University School of Medicine, USA
BAR Proteins and Vesicle Budding

Tuesday, January 24 | 8:00AM - 11:15AM
Clathrin-Dependent Endocytosis
Room: Mountain/Lake

Speaker 4 of 7
Vadim A. Frolov, University of the Basque Country, Spain
Short Talk: Catalytic Pathway of Membrane Remodeling by a Minimal Dynamin Complex

Tuesday, January 24 | 8:00AM - 11:15AM
Clathrin-Dependent Endocytosis
Room: Mountain/Lake

Speaker 5 of 7
Oliver Daumke, Max-Delbrück-Center for Molecular Medicine (MDC), Germany
Structure, Function and Mechanism of Dynamin Superfamily Proteins

Tuesday, January 24 | 8:00AM - 11:15AM
Clathrin-Dependent Endocytosis
Room: Mountain/Lake

Speaker 6 of 7
Joshua S. Chappie, NIDDK/National Institutes of Health, USA
Short Talk: A Pseudo-Atomic Model of the Dynamin Polymer Identifies a Hydrolysis-Dependent Powerstroke

Tuesday, January 24 | 8:00AM - 11:15AM
Clathrin-Dependent Endocytosis
Room: Mountain/Lake

Speaker 7 of 7
Hiroyuki Kamiguchi, RIKEN Brain Science Institute, Japan
Growth Cone Membrane Trafficking for Axon Guidance

Tuesday, January 24 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Tuesday, January 24 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Tuesday, January 24 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, January 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Tuesday, January 24 | 2:30PM - 4:30PM
Workshop: Vesicle Biogenesis and Secretion
Room: Mountain/Lake

Speaker 1 of 8
* Ira Mellman, Genentech, Inc., USA

Tuesday, January 24 | 2:30PM - 4:30PM
Workshop: Vesicle Biogenesis and Secretion
Room: Mountain/Lake

Speaker 2 of 8
Cédric Asensio, University of California, San Franciso, USA
Adaptor Protein AP-3 and VPS41 are Required for the Biogenesis of the Regulated Secretory Pathway

Tuesday, January 24 | 2:30PM - 4:30PM
Workshop: Vesicle Biogenesis and Secretion
Room: Mountain/Lake

Speaker 3 of 8
Daniel Kümmel, Yale School of Medicine, USA
Structural Basis for Clamping of Membrane Fusion by Complexin

Tuesday, January 24 | 2:30PM - 4:30PM
Workshop: Vesicle Biogenesis and Secretion
Room: Mountain/Lake

Speaker 4 of 8
Roberto Weigert, NIDCR-National Institutes of Health, USA
Role for the Acto-Myosin Complex in Regulated Exocytosis Revealed by Intravital Microscopy

Tuesday, January 24 | 2:30PM - 4:30PM
Workshop: Vesicle Biogenesis and Secretion
Room: Mountain/Lake

Speaker 5 of 8
Christian Ungermann, University of Osnabrück, Germany
Molecular Architecture and Function of the HOPS Tethering Complex

Tuesday, January 24 | 2:30PM - 4:30PM
Workshop: Vesicle Biogenesis and Secretion
Room: Mountain/Lake

Speaker 6 of 8
Evzen Boura, Institute of Organic Chemistry and Biochemistry, Czech Republic
Solution Structure and Mechanism of the ESCRT-I and –II Membrane Budding Assembly

Tuesday, January 24 | 2:30PM - 4:30PM
Workshop: Vesicle Biogenesis and Secretion
Room: Mountain/Lake

Speaker 7 of 8
Aaron T. Cheng, University of California, Berkeley, USA
Genome Editing in Embryonic Stem Cells for Live-Cell Analysis of Clathrin-Mediated Endocytosis



Tuesday, January 24 | 2:30PM - 4:30PM
Workshop: Vesicle Biogenesis and Secretion
Room: Mountain/Lake

Speaker 8 of 8
Junjie Hu, Nankai University, China
Structural Insight into Golgi Membrane Stacking by GRASP55 and GRASP65

Tuesday, January 24 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Tuesday, January 24 | 5:00PM - 7:00PM
Clathrin-Independent Endocytosis
Room: Mountain/Lake

Speaker 1 of 5
* Richard Lundmark, Umeå University, Sweden

Tuesday, January 24 | 5:00PM - 7:00PM
Clathrin-Independent Endocytosis
Room: Mountain/Lake

Speaker 2 of 5
Satyajit Mayor, National Centre for Biological Sciences, India
Regulated Organization of Cell Surface Molecules Templated by Dynamic Cortical Actin

Tuesday, January 24 | 5:00PM - 7:00PM
Clathrin-Independent Endocytosis
Room: Mountain/Lake

Speaker 3 of 5
Robert G. Parton, University of Queensland, Australia
New Insights into the Formation and Function of Caveolae

Tuesday, January 24 | 5:00PM - 7:00PM
Clathrin-Independent Endocytosis
Room: Mountain/Lake

Speaker 4 of 5
Julie G. Donaldson, NHLBI, National Institutes of Health, USA
Clathrin-Independent Endocytosis: Sorting of Cargo Proteins after Entry

Tuesday, January 24 | 5:00PM - 7:00PM
Clathrin-Independent Endocytosis
Room: Mountain/Lake

Speaker 5 of 5
Derek C. Prosser, Johns Hopkins University, USA
Short Talk: Existence of a Novel Clathrin-Independent Endocytic Pathway in Yeast that Depends on Rho1 and the Formin Bni1

Tuesday, January 24 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Tuesday, January 24 | 8:00PM - 10:00PM
Poster Session 2
Room: Bay


Tuesday, January 24 | 8:00PM - 9:00PM
Social Hour
Room: Bay


Wednesday, January 25 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, January 25 | 8:00AM - 11:15AM
Membrane Dynamics I: Cell Fusion Mechanisms
Room: Mountain/Lake

Speaker 1 of 7
* Harvey T. McMahon, MRC Laboratory of Molecular Biology, UK

Wednesday, January 25 | 8:00AM - 11:15AM
Membrane Dynamics I: Cell Fusion Mechanisms
Room: Mountain/Lake

Speaker 2 of 7
Benjamin Podbilewicz, Technion, Israel
The Role of EFF and AFF Proteins in Cell-Cell Fusion both in vivo and in vitro

Wednesday, January 25 | 8:00AM - 11:15AM
Membrane Dynamics I: Cell Fusion Mechanisms
Room: Mountain/Lake

Speaker 3 of 7
Roy Duncan, Dalhousie University, Canada
The Reovirus FAST Proteins: Virus-Encoded Cellular Fusogens

Wednesday, January 25 | 8:00AM - 11:15AM
Membrane Dynamics I: Cell Fusion Mechanisms
Room: Mountain/Lake

Speaker 4 of 7
Renjith Mathew, EMBL, Germany
Short Talk: Membrane Dynamics during Polarized Growth of Tracheal Terminal Cells in Drosophila

Wednesday, January 25 | 8:00AM - 11:15AM
Membrane Dynamics I: Cell Fusion Mechanisms
Room: Mountain/Lake

Speaker 5 of 7
Masaru Okabe, Osaka University, Japan
The Dynamic Movement of IZUMO1 and CD9 during Fertilization Process in Mouse

Wednesday, January 25 | 8:00AM - 11:15AM
Membrane Dynamics I: Cell Fusion Mechanisms
Room: Mountain/Lake

Speaker 6 of 7
Gavin J. Wright, Wellcome Trust Sanger Institute, UK
Jamb and Jamc are Essential for Vertebrate Myocyte Fusion

Wednesday, January 25 | 8:00AM - 11:15AM
Membrane Dynamics I: Cell Fusion Mechanisms
Room: Mountain/Lake

Speaker 7 of 7
Pablo S. Aguilar, Institut Pasteur de Montevideo, Uruguay
Short Talk: Yeast Mating, Cell Fusion and Lysis

Wednesday, January 25 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Wednesday, January 25 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Wednesday, January 25 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, January 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Wednesday, January 25 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Wednesday, January 25 | 5:00PM - 7:00PM
Membrane Curvature as a Biological Effector
Room: Mountain/Lake

Speaker 1 of 5
* Christian Ungermann, University of Osnabrück, Germany

Wednesday, January 25 | 5:00PM - 7:00PM
Membrane Curvature as a Biological Effector
Room: Mountain/Lake

Speaker 2 of 5
Darryl Y. Sasaki, Sandia National Laboratories, USA
Model Systems for Understanding Membrane Budding and Tubulation

Wednesday, January 25 | 5:00PM - 7:00PM
Membrane Curvature as a Biological Effector
Room: Mountain/Lake

Speaker 3 of 5
Sascha Martens, University of Vienna, Austria
Molecular Mechanisms of Autophagosome Formation

Wednesday, January 25 | 5:00PM - 7:00PM
Membrane Curvature as a Biological Effector
Room: Mountain/Lake

Speaker 4 of 5
Bruno Antonny, Institut de Pharmacologie Moleculaire et Cellulaire, France
Curvature Sensing and Golgi Trafficking

Wednesday, January 25 | 5:00PM - 7:00PM
Membrane Curvature as a Biological Effector
Room: Mountain/Lake

Speaker 5 of 5
Ralf Langen, University of Southern California, USA
Short Talk: Relation between Protein Structure and Different Types of Membrane Curvature

Wednesday, January 25 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Wednesday, January 25 | 8:00PM - 10:00PM
Poster Session 3
Room: Bay


Wednesday, January 25 | 8:00PM - 9:00PM
Social Hour
Room: Bay


Thursday, January 26 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Thursday, January 26 | 8:00AM - 11:30AM
Membrane Dynamics II: Organelle Fission and Fusion Mechanism
s

Room: Mountain/Lake

Speaker 1 of 8
* Junjie Hu, Nankai University, China

Thursday, January 26 | 8:00AM - 11:30AM
Membrane Dynamics II: Organelle Fission and Fusion Mechanism
s

Room: Mountain/Lake

Speaker 2 of 8
Jodi Nunnari, University of California, Davis, USA
Mitochondrial Dynamics

Thursday, January 26 | 8:00AM - 11:30AM
Membrane Dynamics II: Organelle Fission and Fusion Mechanism
s

Room: Mountain/Lake

Speaker 3 of 8
Ruth N. Collins, Cornell University, USA

Thursday, January 26 | 8:00AM - 11:30AM
Membrane Dynamics II: Organelle Fission and Fusion Mechanism
s

Room: Mountain/Lake

Speaker 4 of 8
Peter Novick, University of California, San Diego, USA
Short Talk: ER Network Structure Requires a Balance between the Dynamin-like GTPase Sey1p and a Novel Member of a Conserved Protein Family

Thursday, January 26 | 8:00AM - 11:30AM
Membrane Dynamics II: Organelle Fission and Fusion Mechanism
s

Room: Mountain/Lake

Speaker 5 of 8
Qing Zhong, University of California at Berkeley, USA
The Class III PI-3Kinase in Autophagosome Formation and Maturation

Thursday, January 26 | 8:00AM - 11:30AM
Membrane Dynamics II: Organelle Fission and Fusion Mechanism
s

Room: Mountain/Lake

Speaker 6 of 8
Thomas Wollert, Institut Pasteur Paris, France
Coatless: Membrane Budding and Scission by the ESCRT-Complexes

Thursday, January 26 | 8:00AM - 11:30AM
Membrane Dynamics II: Organelle Fission and Fusion Mechanism
s

Room: Mountain/Lake

Speaker 7 of 8
Holger Sondermann, Cornell University, USA
Short Talk: Structural Insights into the Molecular Mechanism of the G Protein Atlastin

Thursday, January 26 | 8:00AM - 11:30AM
Membrane Dynamics II: Organelle Fission and Fusion Mechanism
s

Room: Mountain/Lake

Speaker 8 of 8
Caroline Bruns, Center for Genomic Regulation, CRG, Spain
Short Talk: Biogenesis of a Novel Compartment for Autophagosome-Mediated Unconventional Protein Secretion

Thursday, January 26 | 9:00AM - 9:20AM
Coffee Break
Room: Pre Function


Thursday, January 26 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Thursday, January 26 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Thursday, January 26 | 5:00PM - 7:00PM
Membrane Quality Control Pathways
Room: Mountain/Lake

Speaker 1 of 6
* Jodi Nunnari, University of California, Davis, USA

Thursday, January 26 | 5:00PM - 7:00PM
Membrane Quality Control Pathways
Room: Mountain/Lake

Speaker 2 of 6
Richard J. Youle, NINDS, National Institutes of Health, USA
Damage Control - How the Pink1/Parkin Pathway can Regulate Removal of Impaired Mitochondria by Autophagy

Thursday, January 26 | 5:00PM - 7:00PM
Membrane Quality Control Pathways
Room: Mountain/Lake

Speaker 3 of 6
Suresh Subramani, University of California, San Diego, USA
Common Principles in Selective Autophagy from Studies on Pexophagy

Thursday, January 26 | 5:00PM - 7:00PM
Membrane Quality Control Pathways
Room: Mountain/Lake

Speaker 4 of 6
Thomas Langer, CECAD Research Center, Germany
Prohibitins and Mitochondrial Membrane Dynamics

Thursday, January 26 | 5:00PM - 7:00PM
Membrane Quality Control Pathways
Room: Mountain/Lake

Speaker 5 of 6
Brooke M. Gardner, University of California, San Francisco, USA
Short Talk: Unfolded Proteins are Ire1-Activating Ligands that Directly Induce the Unfolded Protein Response

Thursday, January 26 | 5:00PM - 7:00PM
Membrane Quality Control Pathways
Room: Mountain/Lake

Speaker 6 of 6
Marijn Gerard Johannesburg Ford, UC Davis, USA
Short Talk:

Thursday, January 26 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Thursday, January 26 | 8:00PM - 11:00PM
Entertainment
Room: Granhall


Thursday, January 26 | 8:00PM - 11:00PM
Cash Bar
Room: Granhall


Friday, January 27 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.