Web Desc
Gene Silencing by Small RNAs
Organizer(s): Richard W. Carthew and Olivier Voinnet
Date: February 07 - 12, 2012
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Supported by the Directors' Fund
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Summary of Meeting:
The impact of small non-coding RNAs has profoundly touched the fields of development and cell biology, functional genomics, human disease and drug therapy. This mode of gene regulation is not restricted to eukaryotes; bacteria utilize small RNAs, notably those made from CRISPR loci that silence the expression of bacteriophages, transposons and plasmids. There are still many gaps in our knowledge of the mechanisms used by small RNAs, particularly newly discovered RNAs. It has become clear that this field of study needs an annual forum to enable rapid dissemination of new discoveries between researchers. Overall, the goals of this proposed meeting are: (1) to foster the scientific development of junior investigators by promoting their interaction with established investigators, and (2) to allow for mixing and sharing of ideas between biochemists, molecular biologists, geneticists and systems biologists working in the field. We hope this will synergize ideas and method breakthroughs in small RNA mechanisms.
Scholarship Deadline: October 6 2011
Discounted Abstract Deadline: October 6 2011
Abstract Deadline: November 10 2011
Discounted Registration Deadline: December 14 2011
We gratefully acknowledge additional support for this conference from:
Alnylam Pharmaceuticals, Inc.Found AnimalsIntegrated DNA TechnologiesSigma Life Science
We gratefully acknowledge the generous grant for this conference provided by:

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Grant No. 1R13HD070616-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 07 | 3:00PM - 7:30PM
Registration
Room: British Columbia Foyer


Tuesday, February 07 | 6:15PM - 7:15PM
Refreshments
Room: British Columbia Foyer


Tuesday, February 07 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: British Columbia Ballroom

Speaker 1 of 1
Susan Gottesman, NCI, National Institutes of Health, USA
Unraveling Small RNA Function in E. coli

Wednesday, February 08 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Wednesday, February 08 | 8:00AM - 11:15AM
Prokaryote and Eukaryote Models of RNA Silencing
Room: British Columbia Ballroom

Speaker 1 of 8
* Olivier Voinnet, Swiss Federal Institute of Technology, Zürich, Switzerland

Wednesday, February 08 | 8:00AM - 11:15AM
Prokaryote and Eukaryote Models of RNA Silencing
Room: British Columbia Ballroom

Speaker 2 of 8
Jörg Vogel, University of Würzburg, Germany
RNA Ping-Pong in the GcvB Regulon

Wednesday, February 08 | 8:00AM - 11:15AM
Prokaryote and Eukaryote Models of RNA Silencing
Room: British Columbia Ballroom

Speaker 3 of 8
Erik Sontheimer, University of Massachusetts Medical School, USA
CRISPRs and their Role in Limiting Horizontal Gene Transfer

Wednesday, February 08 | 8:00AM - 11:15AM
Prokaryote and Eukaryote Models of RNA Silencing
Room: British Columbia Ballroom

Speaker 4 of 8
Daan C. Swarts, Wageningen University and Researchcentre, Netherlands
Short Talk: CRISPR-Mediated Plasmid Curing in Escherichia coli

Wednesday, February 08 | 8:00AM - 11:15AM
Prokaryote and Eukaryote Models of RNA Silencing
Room: British Columbia Ballroom

Speaker 5 of 8
Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
Dicer/TRBP Interactions Influence Human Regulatory RNA Processing and Targeting

Wednesday, February 08 | 8:00AM - 11:15AM
Prokaryote and Eukaryote Models of RNA Silencing
Room: British Columbia Ballroom

Speaker 6 of 8
Annick Harel-Bellan, Commissariat à l'Energie Atomique (CEA), Saclay, France
Short Talk: Human Nuclear Argonaute Couples Chromatin-Mediated Silencing to Regulation of Alternative Splicing

Wednesday, February 08 | 8:00AM - 11:15AM
Prokaryote and Eukaryote Models of RNA Silencing
Room: British Columbia Ballroom

Speaker 7 of 8
Carl D. Novina, Dana-Farber Cancer Institute, USA
Short Talk: Reduced Expression of Ribosomal Proteins Relieves microRNA-Mediated Repression

Wednesday, February 08 | 8:00AM - 11:15AM
Prokaryote and Eukaryote Models of RNA Silencing
Room: British Columbia Ballroom

Speaker 8 of 8
Alejandro Vasquez-Rifo, University of Massachusetts Medical School, USA
Short Talk: A Vesicular Trafficking Complex Linked to the C. elegans microRNA Pathway

Wednesday, February 08 | 9:20AM - 9:40AM
Coffee Break
Room: British Columbia Foyer


Wednesday, February 08 | 11:15AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Wednesday, February 08 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, February 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Wednesday, February 08 | 4:30PM - 5:00PM
Coffee Available
Room: British Columbia Foyer


Wednesday, February 08 | 5:00PM - 7:00PM
Non-Coding RNA Biogenesis in Eukaryotes
Room: British Columbia Ballroom

Speaker 1 of 6
* Robert A. Martienssen, Cold Spring Harbor Laboratory, USA

Wednesday, February 08 | 5:00PM - 7:00PM
Non-Coding RNA Biogenesis in Eukaryotes
Room: British Columbia Ballroom

Speaker 2 of 6
V. Narry Kim, Institute for Basic Science, South Korea
Regulation of MicroRNA

Wednesday, February 08 | 5:00PM - 7:00PM
Non-Coding RNA Biogenesis in Eukaryotes
Room: British Columbia Ballroom

Speaker 3 of 6
Jillian S. Shapiro, Mount Sinai School of Medicine, USA
Short Talk: In vivo Cytoplasmic Processing of Primary miRNAs

Wednesday, February 08 | 5:00PM - 7:00PM
Non-Coding RNA Biogenesis in Eukaryotes
Room: British Columbia Ballroom

Speaker 4 of 6
Mikiko C. Siomi, University of Tokyo, Japan
Biogenesis of piRNAs

Wednesday, February 08 | 5:00PM - 7:00PM
Non-Coding RNA Biogenesis in Eukaryotes
Room: British Columbia Ballroom

Speaker 5 of 6
Pablo A. Manavella, Max Planck Institute for Developmental Biology, Germany
Short Talk: Identification of New miRNA Biogenesis Cofactors by Fast-Forward Genetics

Wednesday, February 08 | 5:00PM - 7:00PM
Non-Coding RNA Biogenesis in Eukaryotes
Room: British Columbia Ballroom

Speaker 6 of 6
Yi Liu, University of Texas Southwestern Medical Center, USA
Short Talk: Reconstitution of an Argonaute-Dependent Small RNA Biogenesis Pathway Reveals the Roles of Exosome and the Exonuclease QIP in Small RNA Maturation

Wednesday, February 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Wednesday, February 08 | 7:30PM - 10:00PM
Poster Session 1
Room: Pacific Ballroom


Thursday, February 09 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Thursday, February 09 | 8:00AM - 11:15AM
Chromatin and Transcriptional Regulation
Room: British Columbia Ballroom

Speaker 1 of 7
* Susan Gottesman, NCI, National Institutes of Health, USA

Thursday, February 09 | 8:00AM - 11:15AM
Chromatin and Transcriptional Regulation
Room: British Columbia Ballroom

Speaker 2 of 7
Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
S. pombe as a Model for Transcriptional Silencing


Thursday, February 09 | 8:00AM - 11:15AM
Chromatin and Transcriptional Regulation
Room: British Columbia Ballroom

Speaker 3 of 7
Jian-Kang Zhu, Purdue University and Shanghai Center for Plant Stress Biology, CAS, USA
Dynamic Regulation of DNA Methylation in Arabidopsis

Thursday, February 09 | 8:00AM - 11:15AM
Chromatin and Transcriptional Regulation
Room: British Columbia Ballroom

Speaker 4 of 7
Marc Bühler, Friedrich Miescher Institute for Biomedical Research, Switzerland
EMBO Young Investigator Short Talk: Identification of a Silencing Factor that Links Transcription within Heterochromatin to Downstream RNA Degradation

Thursday, February 09 | 8:00AM - 11:15AM
Chromatin and Transcriptional Regulation
Room: British Columbia Ballroom

Speaker 5 of 7
Scott G. Kennedy, University of Wisconsin, USA
Multi-Generational RNAi Inheritance and Germline Immortality

Thursday, February 09 | 8:00AM - 11:15AM
Chromatin and Transcriptional Regulation
Room: British Columbia Ballroom

Speaker 6 of 7
Eva-Maria Weick, Wellcome Trust/Cancer Research UK Gurdon Institute, UK
Short Talk: Transgenerational Epigenetic Inheritance in C. elegans: the Role of Small RNAs

Thursday, February 09 | 8:00AM - 11:15AM
Chromatin and Transcriptional Regulation
Room: British Columbia Ballroom

Speaker 7 of 7
Elissa P. Lei, NIDDK, National Institutes of Health, USA
Nuclear Functions for Drosophila AGO2 on Chromatin

Thursday, February 09 | 9:20AM - 9:40AM
Coffee Break
Room: British Columbia Foyer


Thursday, February 09 | 11:15AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Thursday, February 09 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Thursday, February 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Thursday, February 09 | 4:30PM - 5:00PM
Coffee Available
Room: British Columbia Foyer


Thursday, February 09 | 5:00PM - 7:00PM
Evolution of Small RNAs
Room: British Columbia Ballroom

Speaker 1 of 5
* Phillip D. Zamore, University of Massachusetts Medical School, USA

Thursday, February 09 | 5:00PM - 7:00PM
Evolution of Small RNAs
Room: British Columbia Ballroom

Speaker 2 of 5
David P. Bartel, Massachusetts Institute of Technology and Whitehead Institute, USA
Systems Approaches to miRNAs

Thursday, February 09 | 5:00PM - 7:00PM
Evolution of Small RNAs
Room: British Columbia Ballroom

Speaker 3 of 5
Emily Knouf, Fred Hutchinson Cancer Research Center, USA
Short Talk: Nucleotidyl Transferase Enzymes Regulate the Complexity and Expression of the microRNA Transcriptome

Thursday, February 09 | 5:00PM - 7:00PM
Evolution of Small RNAs
Room: British Columbia Ballroom

Speaker 4 of 5
James C. Carrington, Donald Danforth Plant Science Center, USA
Evolutionary Biology of Small RNAs in Plants

Thursday, February 09 | 5:00PM - 7:00PM
Evolution of Small RNAs
Room: British Columbia Ballroom

Speaker 5 of 5
Eric Meyer, Institut de Biologie de l'Ecole Normale Superieure, France
The scnRNA Pathway: A Highly Flexible Mechanism for Non-Mendelian Inheritance of Mating Types in the Ciliate Paramecium aurelia

Thursday, February 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Thursday, February 09 | 7:30PM - 10:00PM
Poster Session 2
Room: Pacific Ballroom


Friday, February 10 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Friday, February 10 | 8:00AM - 11:15AM
Mechanistic Nature of miRNAs
Room: British Columbia Ballroom

Speaker 1 of 7
* Jennifer A. Doudna, HHMI/University of California, Berkeley, USA

Friday, February 10 | 8:00AM - 11:15AM
Mechanistic Nature of miRNAs
Room: British Columbia Ballroom

Speaker 2 of 7
Juan Guillermo Betancur, University of Tokyo, Japan
Short Talk: Dicer is Dispensable for Asymmetric RISC Loading in Mammals

Friday, February 10 | 8:00AM - 11:15AM
Mechanistic Nature of miRNAs
Room: British Columbia Ballroom

Speaker 3 of 7
Thomas F. Duchaine, McGill University, Canada
Mechanisms and Regulation of mRNA Deadenylation by RNAi Pathways

Friday, February 10 | 8:00AM - 11:15AM
Mechanistic Nature of miRNAs
Room: British Columbia Ballroom

Speaker 4 of 7
Qinghua Liu, University of Texas Southwestern Medical Center, USA
Short Talk: Autoantigen La Promotes Efficient RNAi, Antiviral Response, and Transposon Silencing by Facilitating Multiple-Turnover RISC Catalysis

Friday, February 10 | 8:00AM - 11:15AM
Mechanistic Nature of miRNAs
Room: British Columbia Ballroom

Speaker 5 of 7
Helge Großhans, Friedrich Miescher Institute - FMI, Switzerland
MicroRNA Turnover

Friday, February 10 | 8:00AM - 11:15AM
Mechanistic Nature of miRNAs
Room: British Columbia Ballroom

Speaker 6 of 7
Antonio J. Giraldez, Yale University School of Medicine, USA
Dynamic Analysis of mRNA Decay, Deadenylation and Ribosome Occupancy in vivo during miRNA Mediated Repression

Friday, February 10 | 8:00AM - 11:15AM
Mechanistic Nature of miRNAs
Room: British Columbia Ballroom

Speaker 7 of 7
Richard W. Carthew, Northwestern University, USA
Genetic Robustness and MicroRNAs

Friday, February 10 | 9:20AM - 9:40AM
Coffee Break
Room: British Columbia Foyer


Friday, February 10 | 11:15AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Friday, February 10 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Friday, February 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Friday, February 10 | 4:30PM - 5:00PM
Coffee Available
Room: British Columbia Foyer


Friday, February 10 | 5:00PM - 7:00PM
Small RNA Effector Proteins
Room: British Columbia Ballroom

Speaker 1 of 5
* James C. Carrington, Donald Danforth Plant Science Center, USA

Friday, February 10 | 5:00PM - 7:00PM
Small RNA Effector Proteins
Room: British Columbia Ballroom

Speaker 2 of 5
Craig C. Mello, University of Massachusetts Medical School, USA
Argonautes in C. elegans


Friday, February 10 | 5:00PM - 7:00PM
Small RNA Effector Proteins
Room: British Columbia Ballroom

Speaker 3 of 5
William Theurkauf, University of Massachusetts Medical Center, USA
Building a Transposon Silencing Compartment

Friday, February 10 | 5:00PM - 7:00PM
Small RNA Effector Proteins
Room: British Columbia Ballroom

Speaker 4 of 5
Amit Anand, Temasek Life Sciences Laboratory, National University of Singapore, Singapore
Short Talk: A Tudor Domain Protein Qin/Kumo is Required for Transposon Repression and HP1 Post Translational Modification, with other piRNA Pathway Components

Friday, February 10 | 5:00PM - 7:00PM
Small RNA Effector Proteins
Room: British Columbia Ballroom

Speaker 5 of 5
Phillip D. Zamore, University of Massachusetts Medical School, USA
Pachytene piRNA Production in Mouse Spermatogenesis

Friday, February 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Friday, February 10 | 7:30PM - 10:00PM
Poster Session 3
Room: Pacific Ballroom


Saturday, February 11 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Saturday, February 11 | 8:00AM - 11:15AM
More Surprises from RNA
Room: British Columbia Ballroom

Speaker 1 of 7
* Mikiko C. Siomi, University of Tokyo, Japan

Saturday, February 11 | 8:00AM - 11:15AM
More Surprises from RNA
Room: British Columbia Ballroom

Speaker 2 of 7
Andrew Fire, Stanford University, USA
A Few Things We Already Know (Or Do We?) about Small RNA Biogenesis and Function

Saturday, February 11 | 8:00AM - 11:15AM
More Surprises from RNA
Room: British Columbia Ballroom

Speaker 3 of 7
Fedor V. Karginov, Cold Spring Harbor Laboratories, USA
Short Talk: Global Changes of Ago2-mRNA Interactions in Stress Response

Saturday, February 11 | 8:00AM - 11:15AM
More Surprises from RNA
Room: British Columbia Ballroom

Speaker 4 of 7
Olivier Voinnet, Swiss Federal Institute of Technology, Zürich, Switzerland
“Caught in the Act” – The Awakening and Demise of a Plant Retrotransposon: When, Where, How?

Saturday, February 11 | 8:00AM - 11:15AM
More Surprises from RNA
Room: British Columbia Ballroom

Speaker 5 of 7
David C. Baulcombe, University of Cambridge, UK
Evolution of RNA Silencing loci in Plants

Saturday, February 11 | 8:00AM - 11:15AM
More Surprises from RNA
Room: British Columbia Ballroom

Speaker 6 of 7
Yijun Qi, Tsinghua University, China
Short Talk: A Role for Small RNAs in DNA Double-Strand Break Repair

Saturday, February 11 | 8:00AM - 11:15AM
More Surprises from RNA
Room: British Columbia Ballroom

Speaker 7 of 7
Christina D. Smolke, Stanford University, USA
Design of Small RNAs for Synthetic Biology

Saturday, February 11 | 9:00AM - 9:20AM
Coffee Break
Room: British Columbia Foyer


Saturday, February 11 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Saturday, February 11 | 4:30PM - 5:00PM
Coffee Available
Room: British Columbia Foyer


Saturday, February 11 | 5:00PM - 7:00PM
Small RNAs in Defense
Room: British Columbia Ballroom

Speaker 1 of 5
* Richard W. Carthew, Northwestern University, USA

Saturday, February 11 | 5:00PM - 7:00PM
Small RNAs in Defense
Room: British Columbia Ballroom

Speaker 2 of 5
Raul Andino, University of California, San Francisco, USA
Antiviral Immunity in Drosophila: Systemic RNAi and Viral Suppressores

Saturday, February 11 | 5:00PM - 7:00PM
Small RNAs in Defense
Room: British Columbia Ballroom

Speaker 3 of 5
Ramesh S. Pillai, University of Geneva, Switzerland
piRNA Biogenesis and Functions of Piwi Protein Complexes

Saturday, February 11 | 5:00PM - 7:00PM
Small RNAs in Defense
Room: British Columbia Ballroom

Speaker 4 of 5
Alexei A. Aravin, California Institute of Technology, USA
piRNA Pathway in Flies and Mice

Saturday, February 11 | 5:00PM - 7:00PM
Small RNAs in Defense
Room: British Columbia Ballroom

Speaker 5 of 5
Séverine Chambeyron, Institute of Human Genetics, France
Short Talk: piRNA-Mediated Transgenerational Inheritance of an Acquired Trait

Saturday, February 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Saturday, February 11 | 8:00PM - 11:00PM
Entertainment
Room: Pacific Ballroom


Saturday, February 11 | 8:00PM - 11:00PM
Cash Bar
Room: Pacific Ballroom


Sunday, February 12 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.