Web Desc
Sirtuins in Metabolism, Aging and Disease
Organizer(s): Aleksey G. Kazantsev, Antonello Mai and Tiago Fleming Outeiro
Date: February 12 - 16, 2012
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Supported by the Directors' Fund
Summary of Meeting:
Sirtuins comprise a unique class of NAD+-dependent enzymes that modify multiple protein substrates to execute diverse biological functions. Sirtuins are key regulators of clinically important cellular and organismal processes including metabolism, cell division and aging. The desire to understand the important determinants of human health and lifespan has resulted in a firestorm of work on the seven mammalian sirtuins in the past decade. The implication of sirtuins in medically important areas such as diabetes, cancer, cardiovascular dysfunction and neurodegenerative disease has catapulted them to a prominent status as potential targets for nutritional and therapeutic development. The Keystone Symposia meeting on Sirtuins in Metabolism, Aging and Disease will address fundamental questions on the regulation, biochemical, molecular and cellular mechanisms and pathways of sirtuins. The significance of sirtuin-dependent regulation of homeostasis with respect to diverse biological organisms will be discussed. We envision that this meeting will evaluate the relevance of sirtuin biology in various human conditions, and provide a unique environment for discussing specific therapeutic strategies.
Scholarship Deadline: October 12 2011
Discounted Abstract Deadline: October 12 2011
Abstract Deadline: November 11 2011
Discounted Registration Deadline: December 12 2011
We gratefully acknowledge additional support for this conference from:
The Ellison Medical FoundationLandes Bioscience
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Sirtris, a GSK Company
We gratefully acknowledge the generous grant for this conference provided by:

National Institute on Aging (NIA)
Grant No. 1R13AG040857-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 12 | 3:00PM - 7:30PM
Registration
Room: Pre Function


Sunday, February 12 | 6:15PM - 7:15PM
Buffet Dinner
Room: Granhall


Sunday, February 12 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Mountain/Lake

Speaker 1 of 2
* Aleksey G. Kazantsev, Harvard Medical School & Massachusetts General Hospital, USA
Welcoming Remarks and Introduction

Sunday, February 12 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Mountain/Lake

Speaker 2 of 2
Leonard P. Guarente, Massachusetts Institute of Technology, USA
Sirtuins Aging and Diseases

Monday, February 13 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, February 13 | 8:00AM - 11:15AM
Sirtuin Biology
Room: Mountain/Lake

Speaker 1 of 7
* Tiago Fleming Outeiro, University Medizin Gottingen, Germany

Monday, February 13 | 8:00AM - 11:15AM
Sirtuin Biology
Room: Mountain/Lake

Speaker 2 of 7
J. Lawrence Marsh, University of California, Irvine, USA
Acetylation Homeostasis and Neurodegeneration: A Delicate Balance

Monday, February 13 | 8:00AM - 11:15AM
Sirtuin Biology
Room: Mountain/Lake

Speaker 3 of 7
Eric M. Verdin, Buck Institute for Research on Aging, USA
Mitochondrial Sirtuins

Monday, February 13 | 8:00AM - 11:15AM
Sirtuin Biology
Room: Mountain/Lake

Speaker 4 of 7
Mario F. Fraga, National Center for Biotechnology, Spain
Role of Sirtuin 1 in Stem Cell Differentiation

Monday, February 13 | 8:00AM - 11:15AM
Sirtuin Biology
Room: Mountain/Lake

Speaker 5 of 7
Katrin F. Chua, Stanford University Medical Center, USA
Chromatin Regulation and Genome Maintenance by Mammalian Sirtuins

Monday, February 13 | 8:00AM - 11:15AM
Sirtuin Biology
Room: Mountain/Lake

Speaker 6 of 7
Christian Neri, Inserm, France
Short Talk: SIRT1, FOXO and their Roles in Longevity and Neurodegenerative Disease

Monday, February 13 | 8:00AM - 11:15AM
Sirtuin Biology
Room: Mountain/Lake

Speaker 7 of 7
Wenzhen Duan, Johns Hopkins University School of Medicine, USA
Short Talk: Neuroprotective Role of Sirt1 in Mammalian Models of Huntington’s Disease through Activation of Multiple Sirt1 Targets

Monday, February 13 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Monday, February 13 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Monday, February 13 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, February 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Monday, February 13 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Monday, February 13 | 5:00PM - 7:00PM
Sirtuin Structure and Biochemistry
Room: Mountain/Lake

Speaker 1 of 5
* Eric M. Verdin, Buck Institute for Research on Aging, USA

Monday, February 13 | 5:00PM - 7:00PM
Sirtuin Structure and Biochemistry
Room: Mountain/Lake

Speaker 2 of 5
John M. Denu, University of Wisconsin-Madison, USA
Chemical and Biological Functions of Sirtuins

Monday, February 13 | 5:00PM - 7:00PM
Sirtuin Structure and Biochemistry
Room: Mountain/Lake

Speaker 3 of 5
Antti Poso, University of Eastern Finland, Finland
Identification of Substrate Mimicking Regulators for Sirtuins

Monday, February 13 | 5:00PM - 7:00PM
Sirtuin Structure and Biochemistry
Room: Mountain/Lake

Speaker 4 of 5
Marcia C. Haigis, Harvard Medical School, USA
Control of Mitochondrial Metabolism by SIRT4

Monday, February 13 | 5:00PM - 7:00PM
Sirtuin Structure and Biochemistry
Room: Mountain/Lake

Speaker 5 of 5
Clemens Steegborn, University of Bayreuth, Germany
Short Talk: Identification and Characterization of Sirtuin Substrates and Modulators

Monday, February 13 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Monday, February 13 | 8:00PM - 10:00PM
Poster Session 1
Room: Bay


Monday, February 13 | 8:00PM - 9:00PM
Social Hour
Room: Bay


Tuesday, February 14 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, February 14 | 8:00AM - 11:15AM
Metabolism and Aging. Session Sponsored by The Ellison Medic
al Foundation

Room: Mountain/Lake

Speaker 1 of 7
* Ruth Luthi-Carter, University of Leicester, UK

Tuesday, February 14 | 8:00AM - 11:15AM
Metabolism and Aging. Session Sponsored by The Ellison Medic
al Foundation

Room: Mountain/Lake

Speaker 2 of 7
David A. Sinclair, Harvard Medical School, USA
New Insights into the Roles of Sirtuins in Aging and Age-Related Diseases

Tuesday, February 14 | 8:00AM - 11:15AM
Metabolism and Aging. Session Sponsored by The Ellison Medic
al Foundation

Room: Mountain/Lake

Speaker 3 of 7
Shin-ichiro Imai, Washington University School of Medicine, USA
SIRT1, the Brain, and the NAD World: The Systemic Regulatory Network for Metabolism, Aging, and Longevity in Mammals

Tuesday, February 14 | 8:00AM - 11:15AM
Metabolism and Aging. Session Sponsored by The Ellison Medic
al Foundation

Room: Mountain/Lake

Speaker 4 of 7
Emma De Fabiani, University of Milan, Italy
Energy Metabolism: Transcriptional and Epigenetic Control

Tuesday, February 14 | 8:00AM - 11:15AM
Metabolism and Aging. Session Sponsored by The Ellison Medic
al Foundation

Room: Mountain/Lake

Speaker 5 of 7
Raul Mostoslavsky, Harvard Medical School, USA
The Histone Deacetylase SIRT6, a Critical Regulator of Glycolytic Metabolism

Tuesday, February 14 | 8:00AM - 11:15AM
Metabolism and Aging. Session Sponsored by The Ellison Medic
al Foundation

Room: Mountain/Lake

Speaker 6 of 7
John E. Dominy, Dana Farber Cancer Institute, USA
Short Talk: The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses PGC-1alpha-Mediated Hepatic Gluconeogenesis

Tuesday, February 14 | 8:00AM - 11:15AM
Metabolism and Aging. Session Sponsored by The Ellison Medic
al Foundation

Room: Mountain/Lake

Speaker 7 of 7
Hening Lin, Cornell University, USA
Short Talk: The Enzymatic Activity of Sirtuins Uncovers Novel Protein Posttranslational Modifications

Tuesday, February 14 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Tuesday, February 14 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Tuesday, February 14 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, February 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Tuesday, February 14 | 2:30PM - 4:30PM
Workshop: Diversity of Sirtuin-Dependent Neuroprotective Mec
hanisms
Room: Mountain/Lake

Speaker 1 of 9
* Aleksey G. Kazantsev, Harvard Medical School & Massachusetts General Hospital, USA

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop: Diversity of Sirtuin-Dependent Neuroprotective Mec
hanisms
Room: Mountain/Lake

Speaker 2 of 9
* Tiago Fleming Outeiro, University Medizin Gottingen, Germany

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop: Diversity of Sirtuin-Dependent Neuroprotective Mec
hanisms
Room: Mountain/Lake

Speaker 3 of 9
Danica Chen, University of California, Berkeley, USA
Stem Cell Aging and Rejuvenation: the Plasticity of Mitochondrial Homeostasis

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop: Diversity of Sirtuin-Dependent Neuroprotective Mec
hanisms
Room: Mountain/Lake

Speaker 4 of 9
Li Gan, Weill Cornell Medicine, USA
SIRT1 in Aging and Neurodegeneration

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop: Diversity of Sirtuin-Dependent Neuroprotective Mec
hanisms
Room: Mountain/Lake

Speaker 5 of 9
Daniel Kaganovich, Hebrew University of Jerusalem, Israel
The IPOD Compartment Modulates Protein Aggregation during Stress and Aging

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop: Diversity of Sirtuin-Dependent Neuroprotective Mec
hanisms
Room: Mountain/Lake

Speaker 6 of 9
Heather Weir, Harvard T. H. Chan School of Public Health, USA
SIRT3 Expression in Alzheimer's Disease Pathology

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop: Diversity of Sirtuin-Dependent Neuroprotective Mec
hanisms
Room: Mountain/Lake

Speaker 7 of 9
Anne H. H. Tseng, Academia Sinica and National Yang Ming University, Taiwan
SIRT3 Crosstalks with FOXO3 Acetylation-Phosphorylation-Ubiquitination to Promote Mitochondrial Homeostasis

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop: Diversity of Sirtuin-Dependent Neuroprotective Mec
hanisms
Room: Mountain/Lake

Speaker 8 of 9
Rita Machado de Oliveira, Instituto de Medicina Molecular, Portugal
Sirt2: Crossing the Bridge between Aging and Neurodegeneration

Tuesday, February 14 | 2:30PM - 4:30PM
Workshop: Diversity of Sirtuin-Dependent Neuroprotective Mec
hanisms
Room: Mountain/Lake

Speaker 9 of 9
Gizem Donmez, Tufts University School of Medicine, USA
SIRT1 Protects against a-Synuclein Aggregation by Activating Molecular Chaperones

Tuesday, February 14 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Tuesday, February 14 | 5:00PM - 7:00PM
Sirtuins in Human Diseases
Room: Mountain/Lake

Speaker 1 of 5
* Antonello Mai, Università degli Studi di Roma La Sapienza, Italy

Tuesday, February 14 | 5:00PM - 7:00PM
Sirtuins in Human Diseases
Room: Mountain/Lake

Speaker 2 of 5
Vittorio Sartorelli, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, USA
Skeletal Muscle Specific Deletion of SirT1 Impairs the Adaptive Metabolic Response to High Fat Feeding

Tuesday, February 14 | 5:00PM - 7:00PM
Sirtuins in Human Diseases
Room: Mountain/Lake

Speaker 3 of 5
Stefanie Dimmeler, University of Frankfurt, Germany
SIRT1-Regulating microRNAs in Cardiovascular Disease and Aging

Tuesday, February 14 | 5:00PM - 7:00PM
Sirtuins in Human Diseases
Room: Mountain/Lake

Speaker 4 of 5
Lucia Altucci, Università degli Studi della Campania Vanvitelli, Italy
Sirtuins as Targets of Anticancer Therapeutic Strategies

Tuesday, February 14 | 5:00PM - 7:00PM
Sirtuins in Human Diseases
Room: Mountain/Lake

Speaker 5 of 5
Alejandro Vaquero, Josep Carreras Leukaemia Research Institute (IJC), Spain
Short Talk: SIRT2 is a Tumor Suppressor that Regulates DNA Replication through the Control of H4K16Ac Levels

Tuesday, February 14 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Tuesday, February 14 | 8:00PM - 10:00PM
Poster Session 2
Room: Bay


Tuesday, February 14 | 8:00PM - 9:00PM
Social Hour
Room: Bay


Wednesday, February 15 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, February 15 | 8:00AM - 11:15AM
Developing Sirtuin-Based Therapies
Room: Mountain/Lake

Speaker 1 of 8
* John M. Denu, University of Wisconsin-Madison, USA

Wednesday, February 15 | 8:00AM - 11:15AM
Developing Sirtuin-Based Therapies
Room: Mountain/Lake

Speaker 2 of 8
Manfred Jung, University of Freiburg, Germany
Targeting the NADinome: Developing Inhibitors of NAD+-Dependent Histone Deacetylases and Related Enzymes

Wednesday, February 15 | 8:00AM - 11:15AM
Developing Sirtuin-Based Therapies
Room: Mountain/Lake

Speaker 3 of 8
Antonello Mai, Università degli Studi di Roma La Sapienza, Italy
Assessing Sirtuins as Drug Targets in Human Illnesses

Wednesday, February 15 | 8:00AM - 11:15AM
Developing Sirtuin-Based Therapies
Room: Mountain/Lake

Speaker 4 of 8
George P. Vlasuk, Navitor Pharmaceuticals, USA
Small Molecule SIRT1 Activation: Mechanism, Pharmacology and Experimental Medicine

Wednesday, February 15 | 8:00AM - 11:15AM
Developing Sirtuin-Based Therapies
Room: Mountain/Lake

Speaker 5 of 8
Yana Cen, University of Texas Medical Branch, USA
Short Talk: Transition States of ADP-ribosylation Catalyzed by Plasmodium falciparum and Archaeoglobus fulgidus Sirtuins

Wednesday, February 15 | 8:00AM - 11:15AM
Developing Sirtuin-Based Therapies
Room: Mountain/Lake

Speaker 6 of 8
Jay H. Chung, NHLBI, National Institutes of Health, USA
Short Talk: Demystifying the Mechanism of Action of Resveratrol and SRT1720 in vivo

Wednesday, February 15 | 8:00AM - 11:15AM
Developing Sirtuin-Based Therapies
Room: Mountain/Lake

Speaker 7 of 8
Beatriz E. Bolivar, University at Albany, SUNY, USA
Short Talk: The Unanticipated Inhibition of Human SIRT6 by the Antituberculous Drug Pyrazinamide and Analogs of Pyrazinamide

Wednesday, February 15 | 8:00AM - 11:15AM
Developing Sirtuin-Based Therapies
Room: Mountain/Lake

Speaker 8 of 8
Lindsey B. Gano, University of Colorado, Anschutz Medical Campus, USA
Short Talk: SRT1720 Ameliorates Age-Related Endothelial Dysfunction: Relation to Regulators of Mitochondrial Function and Antioxidant Enzymes

Wednesday, February 15 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Wednesday, February 15 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, February 15 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Wednesday, February 15 | 5:00PM - 7:00PM
Breaking News and Future Directions
Room: Mountain/Lake

Speaker 1 of 6
* David A. Sinclair, Harvard Medical School, USA

Wednesday, February 15 | 5:00PM - 7:00PM
Breaking News and Future Directions
Room: Mountain/Lake

Speaker 2 of 6
Andrew G. Dillin, University of California, Berkeley, USA
Humoral Control of Mitochondrial Form and Function

Wednesday, February 15 | 5:00PM - 7:00PM
Breaking News and Future Directions
Room: Mountain/Lake

Speaker 3 of 6
Ruth Luthi-Carter, University of Leicester, UK
SIRT2 Inhibition and Cholesterol Biosynthesis

Wednesday, February 15 | 5:00PM - 7:00PM
Breaking News and Future Directions
Room: Mountain/Lake

Speaker 4 of 6
Sergiy Libert, Massachusetts Institute of Technology, USA
Short Talk: SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive

Wednesday, February 15 | 5:00PM - 7:00PM
Breaking News and Future Directions
Room: Mountain/Lake

Speaker 5 of 6
Haim Cohen, Faculty of Life Science, Israel
Late Breaking Short Talk: SIRT 6 Extends the Life of Male Mice

Wednesday, February 15 | 5:00PM - 7:00PM
Breaking News and Future Directions
Room: Mountain/Lake

Speaker 6 of 6
Rafael de Cabo, NIA, National Institutes of Health, USA
Future Perspectives on Targeting Sirtuins for Healthy Aging and Age-Related Diseases

Wednesday, February 15 | 7:15PM - 8:15PM
Dinner
Room: Granhall


Wednesday, February 15 | 8:00PM - 11:00PM
Entertainment
Room: Granhall


Wednesday, February 15 | 8:00PM - 11:00PM
Cash Bar
Room: Granhall


Thursday, February 16 | 10:25AM - 10:25AM
Departure


*Session Chair.