Web Desc
Chemical Biology and Novel Tools in Pharmacology
Organizer(s): Laura L. Kiessling, Kevan M. Shokat and Jason E. Gestwicki
Date: February 12 - 16, 2012
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA
Sponsored by Infinity Pharmaceuticals, Novartis Institutes for BioMedical Research and Onyx Pharmaceuticals, Inc.
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Summary of Meeting:
The best solutions to the most important problems in biomedical science have come from multi-disciplinary research. The discovery of new chemical probes and therapeutics requires cross-cutting expertise and the innovative application of new technologies. Scientific forums have become increasingly specialized and narrow in their scope. The specific purpose of the Keystone Symposia meeting on Chemical Biology and Novel Tools in Pharmacology is to initiate and foster active discussions between academic and industrial researchers in the broader area of pharmacological tools. Rather than focus on a specific disease, model system or technical method, this meeting will bring together a variety of experts whose primary, common trait is their innovative use of chemical and biological approaches to solve important problems in biology. From this organizing principle, the specific aims of this meeting are: (a) to assemble chemists and biologists who may not normally interact with each other; (b) to make new connections between chemists and biologists, academics and industrial scientists; and (c) to provide a forum for an open discourse of modern, cross-platform ideas. An unintended consequence of increasingly specialized forums for scientific discussion is the lack of mechanisms for dissemination of novel ideas, platforms and methodologies. The major innovation of this meeting is that it is designed to encourage and inspire researchers to explore and implement inter-disciplinary, emerging methods in chemical biology and pharmacology to their specific biological questions.
Scholarship Deadline: October 12 2011
Discounted Abstract Deadline: October 12 2011
Abstract Deadline: November 11 2011
Discounted Registration Deadline: December 12 2011
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Infinity PharmaceuticalsNovartis Institutes for BioMedical ResearchOnyx Pharmaceuticals, Inc.
We gratefully acknowledge additional support for this conference from:

ACS Chemical Biology
ActivX Biosciences


Laura L. Kiessling, Ronald T. Raines
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
ACS Chemical Biology
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM100628-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 12 | 3:00PM - 7:30PM
Registration
Room: Promenade


Sunday, February 12 | 6:15PM - 7:15PM
Refreshments
Room: Promenade


Sunday, February 12 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Mesa A-B

Speaker 1 of 1
Christopher T. Walsh, Harvard Medical School, USA
Biosynthetic Morphing of Peptide Backbones and Side Chains into Heterocyclic Scaffolds

Monday, February 13 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Monday, February 13 | 8:00AM - 11:15AM
Chemical Microbiology
Room: Mesa A-B

Speaker 1 of 7
* Ronald W. Woodard, University of Michigan, USA

Monday, February 13 | 8:00AM - 11:15AM
Chemical Microbiology
Room: Mesa A-B

Speaker 2 of 7
Nathan A. Magarvey, McMaster University, Canada
Mining Microbiomes for Genetically Encoded Bioactive Natural Products

Monday, February 13 | 8:00AM - 11:15AM
Chemical Microbiology
Room: Mesa A-B

Speaker 3 of 7
Stephen B. del Cardayre, LS9, Inc., USA
Engineering Microbial Fatty Acid Metabolism for Sustainable Fuel and Chemical Production

Monday, February 13 | 8:00AM - 11:15AM
Chemical Microbiology
Room: Mesa A-B

Speaker 4 of 7
Suzanne Walker, Harvard Medical School, USA
Cell Biology and Enzymology of Cell Wall Biosynthesis

Monday, February 13 | 8:00AM - 11:15AM
Chemical Microbiology
Room: Mesa A-B

Speaker 5 of 7
Laura L. Kiessling, Massachusetts Institute of Technology, USA
The Chemistry and Biology of Mycobacterial Polysaccharide Assembly

Monday, February 13 | 8:00AM - 11:15AM
Chemical Microbiology
Room: Mesa A-B

Speaker 6 of 7
Douglas B. Weibel, Amazon.com, Inc., USA
Short Talk: Bacteria Control Intracellular Organization by Straining Their Cytoplasmic Membrane

Monday, February 13 | 8:00AM - 11:15AM
Chemical Microbiology
Room: Mesa A-B

Speaker 7 of 7
Howard C. Hang, Rockefeller University, USA
Short Talk: Chemical Reporters for Dissecting Host-Pathogen Interactions

Monday, February 13 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Monday, February 13 | 11:15AM - 1:00PM
Poster Setup
Room: Mesa C


Monday, February 13 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, February 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Monday, February 13 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Monday, February 13 | 5:00PM - 6:25PM
Chemical Communication I
Room: Mesa A-B

Speaker 1 of 4
* Susan L. Clugston, Cubist Pharmaceuticals, USA

Monday, February 13 | 5:00PM - 6:25PM
Chemical Communication I
Room: Mesa A-B

Speaker 2 of 4
Sean Cutler, University of California, Riverside, USA
Sidestepping Genetic Redundancy with Small Molecules

Monday, February 13 | 5:00PM - 6:25PM
Chemical Communication I
Room: Mesa A-B

Speaker 3 of 4
Cameron R. Currie, University of Wisconsin-Madison, USA
Drugs from Bugs of Bugs

Monday, February 13 | 5:00PM - 6:25PM
Chemical Communication I
Room: Mesa A-B

Speaker 4 of 4
Erin E. Carlson, Indiana University, USA
Short Talk: Chemical Probes to Explore Histidine Kinase Signaling

Monday, February 13 | 6:25PM - 7:00PM
Probing and Perturbing Cell Signaling I
Room: Mesa A-B

Speaker 1 of 1
Timothy J. Mitchison, Harvard Medical School, USA
How Does Taxol Work as a Medicine?

Monday, February 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa/Ortiz


Monday, February 13 | 7:30PM - 10:00PM
Poster Session 1
Room: Mesa C


Tuesday, February 14 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Tuesday, February 14 | 8:00AM - 11:15AM
Probing and Perturbing Cell Signaling II
Room: Mesa A-B

Speaker 1 of 7
* Sharon Xiaoning Zhao, Amgen Inc, USA

Tuesday, February 14 | 8:00AM - 11:15AM
Probing and Perturbing Cell Signaling II
Room: Mesa A-B

Speaker 2 of 7
Carsten Schultz, European Molecular Biology Laboratory Heidelberg, Germany
Tools for Visualizing Cell Biology

Tuesday, February 14 | 8:00AM - 11:15AM
Probing and Perturbing Cell Signaling II
Room: Mesa A-B

Speaker 3 of 7
Jing Huang, University of California, Los Angeles, USA
Small Molecule Regulators of Aging

Tuesday, February 14 | 8:00AM - 11:15AM
Probing and Perturbing Cell Signaling II
Room: Mesa A-B

Speaker 4 of 7
Tom W. Muir, Princeton University, USA
Protein Ligation: An Enabling Technology for Studying Protein Post-Translational Modifications

Tuesday, February 14 | 8:00AM - 11:15AM
Probing and Perturbing Cell Signaling II
Room: Mesa A-B

Speaker 5 of 7
Kevan M. Shokat, University of California, San Francisco, USA
Chemical-Genetic Investigations of Protein and Lipid Kinase Signaling

Tuesday, February 14 | 8:00AM - 11:15AM
Probing and Perturbing Cell Signaling II
Room: Mesa A-B

Speaker 6 of 7
Matthew R. Pratt, University of Southern California, USA
Short Talk: O-GlcNAc as a Link Between Metabolism and Survival in Cancer

Tuesday, February 14 | 8:00AM - 11:15AM
Probing and Perturbing Cell Signaling II
Room: Mesa A-B

Speaker 7 of 7
Morgan Huse, Memorial Sloan Kettering Cancer Center, USA
Short Talk: A Photochemical Approach to Lymphocyte Signaling Dynamics

Tuesday, February 14 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Tuesday, February 14 | 11:15AM - 1:00PM
Poster Setup
Room: Mesa C


Tuesday, February 14 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, February 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Tuesday, February 14 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Tuesday, February 14 | 5:00PM - 7:00PM
Protein Quality Control
Room: Mesa A-B

Speaker 1 of 6
* Susan Wiedner, Pacific Northwest National Laboratory, USA

Tuesday, February 14 | 5:00PM - 7:00PM
Protein Quality Control
Room: Mesa A-B

Speaker 2 of 6
Jason E. Gestwicki, University of California, San Francisco, USA
Molecular Chaperones and Protein Folding: Chemical Tools for Probing Quality Control

Tuesday, February 14 | 5:00PM - 7:00PM
Protein Quality Control
Room: Mesa A-B

Speaker 3 of 6
Julian Adams, Vedantra Pharmaceuticals, Inc., USA
Natural Product-Derived Inhibitor of the Hedgehog Pathway and Clinical Development to Treat Cancer

Tuesday, February 14 | 5:00PM - 7:00PM
Protein Quality Control
Room: Mesa A-B

Speaker 4 of 6
Raquel L. Lieberman, Georgia Institute of Technology, USA
Short Talk: Pharmacological Chaperone Development for the Glaucoma-Associated Olfactomedin Domain of Myocilin

Tuesday, February 14 | 5:00PM - 7:00PM
Protein Quality Control
Room: Mesa A-B

Speaker 5 of 6
Eric R. Strieter, University of Wisconsin, USA
Short Talk: Non-Enzymatic Synthesis of Polyubiquitin Chains

Tuesday, February 14 | 5:00PM - 7:00PM
Protein Quality Control
Room: Mesa A-B

Speaker 6 of 6
Kurt Dwaine Deshayes, Genentech, Inc., USA
Short Talk: Peptide Sensors of Angiogenesis

Tuesday, February 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa/Ortiz


Tuesday, February 14 | 8:00PM - 10:00PM
Poster Session 2
Room: Mesa C


Wednesday, February 15 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Wednesday, February 15 | 8:00AM - 10:25AM
Probing and Perturbing Cell Signaling III
Room: Mesa A-B

Speaker 1 of 5
* Alison N. Hulme, University of Edinburgh, UK

Wednesday, February 15 | 8:00AM - 10:25AM
Probing and Perturbing Cell Signaling III
Room: Mesa A-B

Speaker 2 of 5
Ulrike S. Eggert, King's College London, UK
A Chemical Approach to Understanding Cell Division

Wednesday, February 15 | 8:00AM - 10:25AM
Probing and Perturbing Cell Signaling III
Room: Mesa A-B

Speaker 3 of 5
Rebecca W. Heald, University of California, Berkeley, USA
Importazole, a Small Molecule Inhibitor of the Transport Receptor Importin-beta

Wednesday, February 15 | 8:00AM - 10:25AM
Probing and Perturbing Cell Signaling III
Room: Mesa A-B

Speaker 4 of 5
Luke D. Lavis, HHMI/Janelia Farm Research Campus, USA
Short Talk: Targeting Small Molecules with Cellular Specificity using Enzyme–Substrate Pairs

Wednesday, February 15 | 8:00AM - 10:25AM
Probing and Perturbing Cell Signaling III
Room: Mesa A-B

Speaker 5 of 5
E. James Petersson, University of Pennsylvania, USA
Short Talk: Thioamides: Minimalist Chromophores for Monitoring Protein Dynamics In Vitro and In Vivo

Wednesday, February 15 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Wednesday, February 15 | 10:25AM - 11:00AM
Chemical Communication II

Speaker 1 of 1
John W. Kozarich, ActivX Biosciences, Inc., USA
Toward a Functional, Chemoproteomic Interrogation of Kinome and Nucleotide Binding Space

Wednesday, February 15 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Wednesday, February 15 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Wednesday, February 15 | 5:00PM - 7:15PM
Chemical Biology in Model Organisms
Room: Mesa A-B

Speaker 1 of 5
* Jeffrey P. Henderson, Center for Women's Infectious Diseases Research, Washington University, USA

Wednesday, February 15 | 5:00PM - 7:15PM
Chemical Biology in Model Organisms
Room: Mesa A-B

Speaker 2 of 5
Charlie M. Boone, University of Toronto, Canada
Linking Bioactive Compounds to Cellular Targets by High-Throughput Chemical-Genetic Profiling in Yeast

Wednesday, February 15 | 5:00PM - 7:15PM
Chemical Biology in Model Organisms
Room: Mesa A-B

Speaker 3 of 5
Frank C. Schroeder, Boyce Thompson Institute at Cornell University, USA
C. elegans Ascarosides, a Modular Library of Small Molecule Signals

Wednesday, February 15 | 5:00PM - 7:15PM
Chemical Biology in Model Organisms
Room: Mesa A-B

Speaker 4 of 5
Carolyn R. Bertozzi, Stanford University, USA
Bioorthogonal Chemistry for Glycoprofiling and Beyond

Wednesday, February 15 | 5:00PM - 7:15PM
Chemical Biology in Model Organisms
Room: Mesa A-B

Speaker 5 of 5
Jeffery W. Kelly, The Scripps Research Institute, USA
Adapting Proteostasis to Ameliorate Aggregation-Associated Gain-of-Toxic Function Diseases and Developing Folding and Aggregation Sensors of these Maladies

Wednesday, February 15 | 8:15PM - 9:15PM
Social Hour with Lite Bites
Room: Mesa Ballroom


Wednesday, February 15 | 8:15PM - 11:00PM
Entertainment
Room: Mesa Ballroom


Wednesday, February 15 | 9:15PM - 11:00PM
Cash Bar
Room: Mesa Ballroom


Thursday, February 16 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.