Web Desc
Complex Traits: Genomics and Computational Approaches
Organizer(s): Eric Schadt, Stephen H. Friend and Iya G. Khalil
Date: February 20 - 25, 2012
Location: Beaver Run Resort, Breckenridge, CO, USA
Supported by the Directors' Fund
Summary of Meeting:
Complex traits are driven by constellations of genetic and environmental factors interacting in complex ways. Genetic and environmental perturbations do not directly lead to disease but, rather, impact molecular processes that underlie physiological states associated with disease. Therefore, in order to develop a complete understanding of complex traits like disease, biological systems must be queried in a comprehensive fashion in multiple dimensions. Different data dimensions like genotype, gene expression, proteomic and metabolomic offer complementary views that are useful individually and exceptionally valuable collectively. Without mastering the large-scale molecular data that underlies pathophysiological states, without sophisticated mathematical algorithms capable of data integration, and without an appropriate informatics infrastructure to apply these algorithms and translate the results into manageable bites of information that can be consumed by physicians and patients, efforts to realize the dream of personalized medicine will be difficult to achieve. Towards this end of realizing the promise of personalized medicine, the Keystone Symposia meeting on Complex Traits: Genomics and Computational Approaches will focus on three different areas: 1) methods for integrating diverse, large-scale, high-dimensional data with clinical phenotypes to construct predictive models (e.g., networks) of disease; 2) application of integrative biology approaches that combine large-scale molecular and clinical phenotype information to elucidate the underlying causes of disease and to prioritize drug targets and biomarkers; and 3) technological advances that will drive a dramatic explosion in data that will enable better models of disease and solutions to address the problem of how to enable others to share big data, interact with complex models and refine those models to improve our understanding of disease and associated biological processes.
Scholarship Deadline: October 20 2011
Discounted Abstract Deadline: October 20 2011
Abstract Deadline: December 1 2011
Discounted Registration Deadline: January 4 2012
We gratefully acknowledge additional support for this conference from:
Novartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Novartis Institutes for BioMedical Research

Pacific Biosciences
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
S. Karger A.G. - Human Heredity
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, February 20 | 3:00PM - 7:30PM
Registration
Room: Foyer


Monday, February 20 | 6:15PM - 7:15PM
Refreshments
Room: Foyer


Monday, February 20 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Peaks 4-5

Speaker 3 of 3
Leroy E. Hood, Institute for Systems Biology, USA
Systems Approaches to Complex Diseases and the Emergence of Proactive P4 Medicine

Monday, February 20 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Peaks 4-5

Speaker 2 of 3
* Iya G. Khalil, GNS Healthcare, USA

Monday, February 20 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Peaks 4-5

Speaker 1 of 3
* Stephen H. Friend, Sage Bionetworks, USA

Tuesday, February 21 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Tuesday, February 21 | 8:00AM - 11:00AM
The Genetics of Complex Human Diseases
Room: Peaks 4-5

Speaker 5 of 5
Manolis Kellis, Massachusetts Institute of Technology, Broad Institute, USA
Thousands of Regulatory Variants Contribute to Complex Disease in Alzheimer's and Type 1 Diabetes

Tuesday, February 21 | 8:00AM - 11:00AM
The Genetics of Complex Human Diseases
Room: Peaks 4-5

Speaker 4 of 5
Sekar Kathiresan, Verve Therapeutics, USA
A Mendelian Randomization Study for Plasma High-Density Lipoprotein Cholesterol and Risk for Myocardial Infarction

Tuesday, February 21 | 8:00AM - 11:00AM
The Genetics of Complex Human Diseases
Room: Peaks 4-5

Speaker 3 of 5
Elizabeth K. Speliotes, University of Michigan, USA
Genetic Studies of Obesity and Nonalcoholic Fatty Liver Disease

Tuesday, February 21 | 8:00AM - 11:00AM
The Genetics of Complex Human Diseases
Room: Peaks 4-5

Speaker 2 of 5
Mark I. McCarthy, University of Oxford, UK
Diamonds in the Dirt: Defining the Genetic Basis of T2D Susceptibility through Large-Scale Sequencing Studies

Tuesday, February 21 | 8:00AM - 11:00AM
The Genetics of Complex Human Diseases
Room: Peaks 4-5

Speaker 1 of 5
* Johan Lars Markus Björkegren, Icahn School of Medicine at Mount Sinai, USA

Tuesday, February 21 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, February 21 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Tuesday, February 21 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Tuesday, February 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Tuesday, February 21 | 2:30PM - 4:30PM
Workshop: Health Disparities. Supported by Novartis Institu
tes for BioMedical Research
Room: Peaks 4-5

Speaker 3 of 3
Elad Ziv, University of California, San Francisco, USA
Leveraging Genetic Ancestry to Map Complex Traits: Applications to Cancer Susceptibility

Tuesday, February 21 | 2:30PM - 4:30PM
Workshop: Health Disparities. Supported by Novartis Institu
tes for BioMedical Research
Room: Peaks 4-5

Speaker 2 of 3
* M. Eileen Dolan, University of Chicago, USA
Pharmacogenomics of Anticancer Agents in Different World Populations

Tuesday, February 21 | 2:30PM - 4:30PM
Workshop: Health Disparities. Supported by Novartis Institu
tes for BioMedical Research
Room: Peaks 4-5

Speaker 1 of 3
Joshua M. Akey, University of Washington, USA
Personal and Population Genomics of Protein-Coding and Regulatory Variation in Humans

Tuesday, February 21 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, February 21 | 5:00PM - 7:00PM
Network and Pathway-Based Genome-Wide Association Studies
Room: Peaks 4-5

Speaker 5 of 5
Sarah A. Pendergrass, Pennsylvania State University, USA
Short Talk: A Phenome-Wide Exploration of Genotype-Phenotype Associations and Pleiotropy Using MetaboChip in the PAGE Study

Tuesday, February 21 | 5:00PM - 7:00PM
Network and Pathway-Based Genome-Wide Association Studies
Room: Peaks 4-5

Speaker 4 of 5
Andrew G. Clark, Cornell University, USA
Attributes of Metabolic Regulatory Networks Inferred from Natural Polymorphisms in a Reference Panel of Lines of Drosophila melanogaster

Tuesday, February 21 | 5:00PM - 7:00PM
Network and Pathway-Based Genome-Wide Association Studies
Room: Peaks 4-5

Speaker 3 of 5
Judy Zhong, New York University Medical School, USA
Networks of Expression Associated SNPs in Liver and Adipose

Tuesday, February 21 | 5:00PM - 7:00PM
Network and Pathway-Based Genome-Wide Association Studies
Room: Peaks 4-5

Speaker 2 of 5
Barbara E. Stranger, USA
Cis-Regulatory Regions Influencing Immune-Mediated Disease Are a Target of Recent Positive Selection in Humans

Tuesday, February 21 | 5:00PM - 7:00PM
Network and Pathway-Based Genome-Wide Association Studies
Room: Peaks 4-5

Speaker 1 of 5
* Stephen H. Friend, Sage Bionetworks, USA

Tuesday, February 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3


Tuesday, February 21 | 7:30PM - 10:00PM
Poster Session 1
Room: Peaks 1-3


Wednesday, February 22 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Wednesday, February 22 | 8:00AM - 11:00AM
Integrative Genomics Methods for Elucidating the Complexity
of Living Systems

Room: Peaks 4-5

Speaker 1 of 6
* Iya G. Khalil, GNS Healthcare, USA

Wednesday, February 22 | 8:00AM - 11:00AM
Integrative Genomics Methods for Elucidating the Complexity
of Living Systems

Room: Peaks 4-5

Speaker 2 of 6
Atul J. Butte, University of California, San Francisco, USA
Integrating Genome-Wide and Environmental-Wide Association Studies for Data-Driven Personalized Medicine

Wednesday, February 22 | 8:00AM - 11:00AM
Integrative Genomics Methods for Elucidating the Complexity
of Living Systems

Room: Peaks 4-5

Speaker 3 of 6
Eric Schadt, Mount Sinai School of Medicine, USA
Reverse Engineering Biological Systems to Construct Disease Networks

Wednesday, February 22 | 8:00AM - 11:00AM
Integrative Genomics Methods for Elucidating the Complexity
of Living Systems

Room: Peaks 4-5

Speaker 4 of 6
Leonid Kruglyak, Princeton University, USA
Genetic Dissection of Complex Traits in Simple Model Organisms

Wednesday, February 22 | 8:00AM - 11:00AM
Integrative Genomics Methods for Elucidating the Complexity
of Living Systems

Room: Peaks 4-5

Speaker 5 of 6
Dana Pe'er, Memorial Sloan Kettering Cancer Center, USA
On the Road to Personalized Therapy, a Systems Approach

Wednesday, February 22 | 8:00AM - 11:00AM
Integrative Genomics Methods for Elucidating the Complexity
of Living Systems

Room: Peaks 4-5

Speaker 6 of 6
Jennifer Listgarten, Microsoft Research, USA
Short Talk: FaST Linear Mixed Models for Genome-Wide Association Studies

Wednesday, February 22 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, February 22 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Wednesday, February 22 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Wednesday, February 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Wednesday, February 22 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, February 22 | 5:00PM - 7:00PM
Applications of Integrative Genomics Strategies to Match Pat
ients to Treatments of Disease

Room: Peaks 4-5

Speaker 1 of 5
* Stephen H. Friend, Sage Bionetworks, USA

Wednesday, February 22 | 5:00PM - 7:00PM
Applications of Integrative Genomics Strategies to Match Pat
ients to Treatments of Disease

Room: Peaks 4-5

Speaker 2 of 5
Joseph Lehár, Novartis Institutes for BioMedical Research, USA
Approaching Selective Cancer Therapy via a Genomic, Phenotypic and Combination Campaign

Wednesday, February 22 | 5:00PM - 7:00PM
Applications of Integrative Genomics Strategies to Match Pat
ients to Treatments of Disease

Room: Peaks 4-5

Speaker 3 of 5
Andrea Califano, Columbia University, USA
Using Predictive Regulatory Models to Identify Genes That Integrate the Aberrant Signal Spectrum of a Cancer Subtype

Wednesday, February 22 | 5:00PM - 7:00PM
Applications of Integrative Genomics Strategies to Match Pat
ients to Treatments of Disease

Room: Peaks 4-5

Speaker 4 of 5
Euan A. Ashley, Stanford University, USA
Genome Interpretation to Identify Actionable Events That Will Impact Disease Diagnosis and Treatment Strategy

Wednesday, February 22 | 5:00PM - 7:00PM
Applications of Integrative Genomics Strategies to Match Pat
ients to Treatments of Disease

Room: Peaks 4-5

Speaker 5 of 5
Laura Saba, University of Colorado Denver, USA
Short Talk: A “Modular” Approach to Elucidating Genetic Susceptibility to Ventricular Malfunction

Wednesday, February 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3


Wednesday, February 22 | 7:30PM - 10:00PM
Poster Session 2
Room: Peaks 1-3


Thursday, February 23 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Thursday, February 23 | 8:00AM - 11:40AM
Technological Innovation Driving More Highly Accurate Models
of Disease

Room: Peaks 4-5

Speaker 1 of 7
* Johan Lars Markus Björkegren, Icahn School of Medicine at Mount Sinai, USA

Thursday, February 23 | 8:00AM - 11:40AM
Technological Innovation Driving More Highly Accurate Models
of Disease

Room: Peaks 4-5

Speaker 2 of 7
Stephen W. Turner, Pacific Biosciences, USA
Single-Molecule Real-Time Biology

Thursday, February 23 | 8:00AM - 11:40AM
Technological Innovation Driving More Highly Accurate Models
of Disease

Room: Peaks 4-5

Speaker 3 of 7
Garry P. Nolan, Stanford University, USA
Mass Flow Cytometry to Construct Cellular Networks That Predict Disease Outcome

Thursday, February 23 | 8:00AM - 11:40AM
Technological Innovation Driving More Highly Accurate Models
of Disease

Room: Peaks 4-5

Speaker 4 of 7
Jeff Hammerbacher, Medical University of South Carolina, USA
Experiences Evolving an Analytical Platform, with Applications to Health Care and the Life Sciences

Thursday, February 23 | 8:00AM - 11:40AM
Technological Innovation Driving More Highly Accurate Models
of Disease

Room: Peaks 4-5

Speaker 5 of 7
Joel Dudley, Icahn School of Medicine at Mount Sinai, USA
Systems Based Approaches for Connecting Therapeutic Mechanisms to the Molecular Pathophysiology of Disease

Thursday, February 23 | 8:00AM - 11:40AM
Technological Innovation Driving More Highly Accurate Models
of Disease

Room: Peaks 4-5

Speaker 6 of 7
Maya M. Kasowski, Howard Hughes Medical Institute, USA
Short Talk: Variation in Transcription Factor Binding Among Humans

Thursday, February 23 | 8:00AM - 11:40AM
Technological Innovation Driving More Highly Accurate Models
of Disease

Room: Peaks 4-5

Speaker 7 of 7
Trey Ideker, University of California, San Diego, USA
From Networks to Predicting Response to Cancer Treatments

Thursday, February 23 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, February 23 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Thursday, February 23 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, February 23 | 5:00PM - 7:00PM
Data Sharing, Representing Models of Disease and Enabling Co
mmunities of Researchers to Interact

Room: Peaks 4-5

Speaker 1 of 5
* Iya G. Khalil, GNS Healthcare, USA

Thursday, February 23 | 5:00PM - 7:00PM
Data Sharing, Representing Models of Disease and Enabling Co
mmunities of Researchers to Interact

Room: Peaks 4-5

Speaker 2 of 5
Stephen H. Friend, Sage Bionetworks, USA
Use of Bionetworks to Build Maps of Diseases - Moving Beyond the Linear

Thursday, February 23 | 5:00PM - 7:00PM
Data Sharing, Representing Models of Disease and Enabling Co
mmunities of Researchers to Interact

Room: Peaks 4-5

Speaker 3 of 5
Jason Bobe, PersonalGenomes.org, USA
Open Consent Framework for Public Genomics

Thursday, February 23 | 5:00PM - 7:00PM
Data Sharing, Representing Models of Disease and Enabling Co
mmunities of Researchers to Interact

Room: Peaks 4-5

Speaker 4 of 5
Vicki L. Seyfert-Margolis, Food and Drug Administration, USA
Facilitating Data Sharing to Enhance Drug Effectiveness and Safety

Thursday, February 23 | 5:00PM - 7:00PM
Data Sharing, Representing Models of Disease and Enabling Co
mmunities of Researchers to Interact

Room: Peaks 4-5

Speaker 5 of 5
Joel P. Wagner, Massachusetts Institute of Technology, USA
Short Talk: Network Simulation versus Network Inference: Contrasting ‘Omics Modeling Approaches

Thursday, February 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3


Friday, February 24 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Friday, February 24 | 8:00AM - 11:00AM
Reconstructing Biological Networks
Room: Peaks 4-5

Speaker 1 of 5
Alexis Battle, Johns Hopkins University, USA
Using Prior Knowledge to Unravel the Genetic Factors Underlying Complex Traits

Friday, February 24 | 8:00AM - 11:00AM
Reconstructing Biological Networks
Room: Peaks 4-5

Speaker 2 of 5
Iya G. Khalil, GNS Healthcare, USA
Constructing Ensembles of Networks to Predict Disease Phenotype

Friday, February 24 | 8:00AM - 11:00AM
Reconstructing Biological Networks
Room: Peaks 4-5

Speaker 3 of 5
Jun Zhu, Mount Sinai School of Medicine, USA
An Integrative Bayesian Network Approach to Construct Disease Models

Friday, February 24 | 8:00AM - 11:00AM
Reconstructing Biological Networks
Room: Peaks 4-5

Speaker 4 of 5
Marylyn D. Ritchie, Pennsylvania State University, USA
Meta-Dimensional Analysis of Phenotypes to Dissect the Architecture of Complex Traits

Friday, February 24 | 8:00AM - 11:00AM
Reconstructing Biological Networks
Room: Peaks 4-5

Speaker 5 of 5
Jonathan R. Karr, Icahn School of Medicine at Mount Sinai, USA
Short Talk: A Whole Cell Model of Mycoplasma genitalium Elucidates Mechanisms of Bacterial Growth and Replication

Friday, February 24 | 9:00AM - 9:20AM
Coffee Break
Room: Foyer


Friday, February 24 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Friday, February 24 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Friday, February 24 | 5:00PM - 7:00PM
Application of Predictive Gene Networks to Identify the Driv
ers of Disease

Room: Peaks 4-5

Speaker 1 of 3
* Eric Schadt, Mount Sinai School of Medicine, USA

Friday, February 24 | 5:00PM - 7:00PM
Application of Predictive Gene Networks to Identify the Driv
ers of Disease

Room: Peaks 4-5

Speaker 2 of 3
Johan Lars Markus Björkegren, Icahn School of Medicine at Mount Sinai, USA
Construction and Mining of Cross-Tissue and Tissue Networks in Coronary Artery Disease

Friday, February 24 | 5:00PM - 7:00PM
Application of Predictive Gene Networks to Identify the Driv
ers of Disease

Room: Peaks 4-5

Speaker 3 of 3
Alan D. Attie, University of Wisconsin-Madison, USA
Genetic Deconstruction of Type 2 Diabetes

Friday, February 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3


Friday, February 24 | 8:00PM - 11:00PM
Entertainment
Room: Peaks 1-3


Friday, February 24 | 8:00PM - 11:00PM
Cash Bar
Room: Peaks 1-3


Saturday, February 25 | 10:25AM - 10:25AM
Departure


*Session Chair.