Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
RNA-Protein Interactions (2019X1)
Protein-RNA Interactions: Scale, Mechanisms, Structure and Function of Coding and Noncoding RNPs (2017J6)
mRNA Processing and Human Disease (2017C3)

Web Desc
Protein-RNA Interactions in Biology and Disease Organizer(s): Thomas Tuschl, Mikiko C. Siomi and Gideon Dreyfuss Date: March 04 - 09, 2012 Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA Supported by the Directors' Fund Summary of Meeting: Cellular functions depend on numerous protein-coding and noncoding RNAs and the RNA-binding proteins (RBPs) associated with them, which form ribonucleoprotein complexes (RNPs). Mutations that disrupt either the RNA or protein components of RNPs or the factors required for their assembly can be deleterious. The discovery of disease-causing mutations in RNAs or their interacting RBPs not only adds to our growing understanding of RNA biology and chemistry, but also offers new therapeutic targets and contributes to ongoing efforts in developing mRNA-targeting antisense and RNAi therapeutics. This meeting focuses on a general understanding of post-transcriptional gene regulation and how perturbation of complex networks of RNA-protein and RNA-RNP interactions triggers disease. Scholarship Deadline: November 2 2011 Discounted Abstract Deadline: November 2 2011 Abstract Deadline: December 8 2011 Discounted Registration Deadline: January 5 2012 We gratefully acknowledge additional support for this conference from: We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: We gratefully acknowledge the generous grant for this conference provided by: National Institute of Neurological Disorders and Stroke (NINDS) Grant No. 1R13NS076178-01 The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Protein-RNA Interactions in Biology and Disease

Organizer(s): Thomas Tuschl, Mikiko C. Siomi and Gideon Dreyfuss

Date: March 04 - 09, 2012
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA

Supported by the Directors' Fund

Summary of Meeting:

Cellular functions depend on numerous protein-coding and noncoding RNAs and the RNA-binding proteins (RBPs) associated with them, which form ribonucleoprotein complexes (RNPs). Mutations that disrupt either the RNA or protein components of RNPs or the factors required for their assembly can be deleterious. The discovery of disease-causing mutations in RNAs or their interacting RBPs not only adds to our growing understanding of RNA biology and chemistry, but also offers new therapeutic targets and contributes to ongoing efforts in developing mRNA-targeting antisense and RNAi therapeutics. This meeting focuses on a general understanding of post-transcriptional gene regulation and how perturbation of complex networks of RNA-protein and RNA-RNP interactions triggers disease.

Scholarship Deadline: November 2 2011

Discounted Abstract Deadline: November 2 2011

Abstract Deadline: December 8 2011

Discounted Registration Deadline: January 5 2012

We gratefully acknowledge additional support for this conference from:

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS076178-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, March 04 \| 3:00PM - 7:30PM Registration Room: Promenade
Sunday, March 04 \| 6:15PM - 7:15PM Refreshments Room: Promenade
Sunday, March 04 \| 7:15PM - 8:30PM Welcome and Keynote Address Room: Mesa A-B Speaker 1 of 2 * Gideon Dreyfuss, HHMI/University of Pennsylvania School of Medicine, USA
Sunday, March 04 \| 7:15PM - 8:30PM Welcome and Keynote Address Room: Mesa A-B Speaker 2 of 2 Witold Filipowicz, Friedrich Miescher Institute for Biomedical Research, Switzerland Mechanism and Regulation of microRNA Repression in Mammalian Cells
Monday, March 05 \| 7:00AM - 8:00AM Breakfast Room: Chamisa/Ortiz
Monday, March 05 \| 8:00AM - 11:15AM Genetic Diseases Caused by Alterations of RBP or RNA Sequenc e: Part 1 Room: Mesa A-B Speaker 1 of 7 * Reinhard Lührmann, Max Planck Institute for Biophysical Chemistry, Germany
Monday, March 05 \| 8:00AM - 11:15AM Genetic Diseases Caused by Alterations of RBP or RNA Sequenc e: Part 1 Room: Mesa A-B Speaker 2 of 7 Tom Maniatis, New York Genome Center, USA The Role of RNA-Binding Proteins in ALS
Monday, March 05 \| 8:00AM - 11:15AM Genetic Diseases Caused by Alterations of RBP or RNA Sequenc e: Part 1 Room: Mesa A-B Speaker 3 of 7 Francisco E. Baralle, International Center for Genetic Engineering, Italy New Apects of TDP 43 Self-Regulation Mechanisms and their Connection with Neurological Disease
Monday, March 05 \| 8:00AM - 11:15AM Genetic Diseases Caused by Alterations of RBP or RNA Sequenc e: Part 1 Room: Mesa A-B Speaker 4 of 7 Maurice S. Swanson, University of Florida, USA RNA Toxicity in Microsatellite Expansion Disease
Monday, March 05 \| 8:00AM - 11:15AM Genetic Diseases Caused by Alterations of RBP or RNA Sequenc e: Part 1 Room: Mesa A-B Speaker 5 of 7 Nancy M. Bonini, University of Pennsylvania, USA RNA Pathways and their Impact on Brain Degeneration: Insight from Drosophila
Monday, March 05 \| 8:00AM - 11:15AM Genetic Diseases Caused by Alterations of RBP or RNA Sequenc e: Part 1 Room: Mesa A-B Speaker 6 of 7 Susan L. Ackerman, University of California, San Diego, USA Short Talk: Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration
Monday, March 05 \| 8:00AM - 11:15AM Genetic Diseases Caused by Alterations of RBP or RNA Sequenc e: Part 1 Room: Mesa A-B Speaker 7 of 7 Cara L. Lunn, Washington University School of Medicine, USA Short Talk: U2AF1 Mutations in Myelodysplastic Syndromes
Monday, March 05 \| 9:20AM - 9:40AM Coffee Break Room: Promenade
Monday, March 05 \| 11:15AM - 1:00PM Poster Setup Room: Mesa C
Monday, March 05 \| 11:15AM - 11:15AM On Own for Lunch and Recreation
Monday, March 05 \| 1:00PM - 10:00PM Poster Viewing Room: Mesa C
Monday, March 05 \| 4:30PM - 5:00PM Coffee Available Room: Promenade
Monday, March 05 \| 5:00PM - 7:15PM Genetic Diseases Caused by Alterations of RBP or RNA Sequenc e: Part 2 Room: Mesa A-B Speaker 1 of 6 * Thomas R. Cech, HHMI/University of Colorado, USA
Monday, March 05 \| 5:00PM - 7:15PM Genetic Diseases Caused by Alterations of RBP or RNA Sequenc e: Part 2 Room: Mesa A-B Speaker 2 of 6 Randi J. Hagerman, University of California, Davis Health System, USA Fragile X Syndrome and FXTAS
Monday, March 05 \| 5:00PM - 7:15PM Genetic Diseases Caused by Alterations of RBP or RNA Sequenc e: Part 2 Room: Mesa A-B Speaker 3 of 6 Miguel Angel Moreno-Pelayo, Hospital Ramón y Cajal, Spain miR-96 and Hereditary Hearing Loss: First Example of Point Mutations in the Mature Sequence of a miRNA with an Ethiopathogenetic Role in a Human Mendelian Disease
Monday, March 05 \| 5:00PM - 7:15PM Genetic Diseases Caused by Alterations of RBP or RNA Sequenc e: Part 2 Room: Mesa A-B Speaker 4 of 6 Gideon Dreyfuss, HHMI/University of Pennsylvania School of Medicine, USA Function and Mechanism of the SMN Complex: Insights into snRNP Biogenesis, mRNA Regulation and SMA Pathogenesis
Monday, March 05 \| 5:00PM - 7:15PM Genetic Diseases Caused by Alterations of RBP or RNA Sequenc e: Part 2 Room: Mesa A-B Speaker 5 of 6 Shuo-Chien Ling, National University of Singapore, Singapore Short Talk: Progressive Lower Motor Neuron Defects in Mice Expressing Wild Type or ALS-Linked Mutants of FUS/TLS
Monday, March 05 \| 5:00PM - 7:15PM Genetic Diseases Caused by Alterations of RBP or RNA Sequenc e: Part 2 Room: Mesa A-B Speaker 6 of 6 J. Paul Taylor, St. Jude Children's Research Hospital, USA Short Talk: Mutations in Prion-Like Domains Found in hnRNPA2B1 and hnRNPA1 Cause Multisystem Proteinopathy
Monday, March 05 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Chamisa/Ortiz
Monday, March 05 \| 7:30PM - 10:00PM Poster Session 1 Room: Mesa C
Tuesday, March 06 \| 7:00AM - 8:00AM Breakfast Room: Chamisa/Ortiz
Tuesday, March 06 \| 8:00AM - 11:15AM Defining the Elements and Interactions of Post-Transcription al Networks Room: Mesa A-B Speaker 1 of 6 * James L. Manley, Columbia University, USA
Tuesday, March 06 \| 8:00AM - 11:15AM Defining the Elements and Interactions of Post-Transcription al Networks Room: Mesa A-B Speaker 2 of 6 Chris B. Burge, Massachusetts Institute of Technology, USA Regulation of Splicing and Localization of mRNAs by Muscleblind Proteins
Tuesday, March 06 \| 8:00AM - 11:15AM Defining the Elements and Interactions of Post-Transcription al Networks Room: Mesa A-B Speaker 3 of 6 Thomas Tuschl, HHMI/Rockefeller University, USA Defining Post-Transcriptional Regulatory Networks
Tuesday, March 06 \| 8:00AM - 11:15AM Defining the Elements and Interactions of Post-Transcription al Networks Room: Mesa A-B Speaker 4 of 6 Falk Butter, Max Planck Institute for Biochemistry, Germany Mass Spectrometry for Complete Proteome Identification and Post-Transcriptional Regulation
Tuesday, March 06 \| 8:00AM - 11:15AM Defining the Elements and Interactions of Post-Transcription al Networks Room: Mesa A-B Speaker 5 of 6 Stephanie C. Huelga, University of California, San Diego, USA Short Talk: Integrative Genome-Wide Analysis Reveals Cooperative Regulation of Alternative Splicing by hnRNP Proteins
Tuesday, March 06 \| 8:00AM - 11:15AM Defining the Elements and Interactions of Post-Transcription al Networks Room: Mesa A-B Speaker 6 of 6 Andreas R. Gruber, University of Basel, Switzerland Short Talk: Global Maps of Pre-mRNA 3’ End Processing Factor Binding and Polyadenylation Sites
Tuesday, March 06 \| 9:20AM - 9:40AM Coffee Break Room: Promenade
Tuesday, March 06 \| 11:15AM - 1:00PM Poster Setup Room: Mesa C
Tuesday, March 06 \| 11:15AM - 11:15AM On Own for Lunch and Recreation
Tuesday, March 06 \| 1:00PM - 10:00PM Poster Viewing Room: Mesa C
Tuesday, March 06 \| 4:30PM - 5:00PM Coffee Available Room: Promenade
Tuesday, March 06 \| 5:00PM - 7:00PM RNAi Mechanism and miRNAs Room: Mesa A-B Speaker 1 of 5 * Elena Conti, Max Planck Institute of Biochemistry, Germany
Tuesday, March 06 \| 5:00PM - 7:00PM RNAi Mechanism and miRNAs Room: Mesa A-B Speaker 2 of 5 Mikiko C. Siomi, University of Tokyo, Japan Biogenesis of PIWI-Interacting Small RNAs in Drosophila
Tuesday, March 06 \| 5:00PM - 7:00PM RNAi Mechanism and miRNAs Room: Mesa A-B Speaker 3 of 5 V. Narry Kim, Institute for Basic Science, South Korea Regulation of MicroRNA via Monouridylation of Pre-miRNA
Tuesday, March 06 \| 5:00PM - 7:00PM RNAi Mechanism and miRNAs Room: Mesa A-B Speaker 4 of 5 Bryan R. Cullen, Duke University Medical Center, USA Viruses and microRNAs
Tuesday, March 06 \| 5:00PM - 7:00PM RNAi Mechanism and miRNAs Room: Mesa A-B Speaker 5 of 5 Doron Betel, Weill Cornell Medical College, USA Short Talk: Genome Wide Identification of miRNA Target Sites by CLIP-Based Methods
Tuesday, March 06 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Chamisa/Ortiz
Tuesday, March 06 \| 7:30PM - 10:00PM Poster Session 2 Room: Mesa C
Wednesday, March 07 \| 7:00AM - 8:00AM Breakfast Room: Chamisa/Ortiz
Wednesday, March 07 \| 8:00AM - 11:15AM RNPs and RNA Processing: Part 1 Room: Mesa A-B Speaker 1 of 7 * V. Narry Kim, Institute for Basic Science, South Korea
Wednesday, March 07 \| 8:00AM - 11:15AM RNPs and RNA Processing: Part 1 Room: Mesa A-B Speaker 2 of 7 Alberto R. Kornblihtt, Universidad de Buenos Aires, Argentina Chromatin, Epigenetics and Alternative Splicing
Wednesday, March 07 \| 8:00AM - 11:15AM RNPs and RNA Processing: Part 1 Room: Mesa A-B Speaker 3 of 7 James L. Manley, Columbia University, USA Processing of mRNA Precursors and Links to Human Disease
Wednesday, March 07 \| 8:00AM - 11:15AM RNPs and RNA Processing: Part 1 Room: Mesa A-B Speaker 4 of 7 Joan A. Steitz, Yale University, USA Probing Viral Noncoding RNAs to Illuminate Novel microRNA Processing Pathways, Mechanisms of RNA Stability and microRNA Function
Wednesday, March 07 \| 8:00AM - 11:15AM RNPs and RNA Processing: Part 1 Room: Mesa A-B Speaker 5 of 7 Ashley T. Neff, Colorado State University, USA Short Talk: Global Analysis Reveals Pathways of Unique Regulation of mRNA Decay in Human Induced Pluripotent Stem Cells
Wednesday, March 07 \| 8:00AM - 11:15AM RNPs and RNA Processing: Part 1 Room: Mesa A-B Speaker 6 of 7 Thomas R. Cech, HHMI/University of Colorado, USA Two Noncoding RNPs, Telomerase and FUS/TLS
Wednesday, March 07 \| 8:00AM - 11:15AM RNPs and RNA Processing: Part 1 Room: Mesa A-B Speaker 7 of 7 Mauro Costa-Mattioli, Baylor College of Medicine, USA Short Talk: Suppression of PKR Promotes Network Hypersynchrony and Enhanced Cognition by Interferon-gamma Mediated Disinhibition
Wednesday, March 07 \| 9:20AM - 9:40AM Coffee Break Room: Promenade
Wednesday, March 07 \| 11:15AM - 1:00PM Poster Setup Room: Mesa C
Wednesday, March 07 \| 11:15AM - 11:15AM On Own for Lunch and Recreation
Wednesday, March 07 \| 1:00PM - 10:00PM Poster Viewing Room: Mesa C
Wednesday, March 07 \| 4:30PM - 5:00PM Coffee Available Room: Promenade
Wednesday, March 07 \| 5:00PM - 7:00PM RNPs and RNA Processing: Part 2 Room: Mesa A-B Speaker 1 of 5 * Nancy M. Bonini, University of Pennsylvania, USA
Wednesday, March 07 \| 5:00PM - 7:00PM RNPs and RNA Processing: Part 2 Room: Mesa A-B Speaker 2 of 5 Nahum Sonenberg, McGill University, Canada Cap-Binding Proteins and their Role in Translation Initiation
Wednesday, March 07 \| 5:00PM - 7:00PM RNPs and RNA Processing: Part 2 Room: Mesa A-B Speaker 3 of 5 Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets
Wednesday, March 07 \| 5:00PM - 7:00PM RNPs and RNA Processing: Part 2 Room: Mesa A-B Speaker 4 of 5 Benjamin J. Blencowe, University of Toronto, Canada Systematic Analysis of the Function and Regulation of Alternative Exon Networks
Wednesday, March 07 \| 5:00PM - 7:00PM RNPs and RNA Processing: Part 2 Room: Mesa A-B Speaker 5 of 5 Ram Kannan, Stowers Institute For Medical Research, USA Short Talk: Telomerase RNA Biogenesis: Splicing versus Spliceosomal Cleavage
Wednesday, March 07 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Chamisa/Ortiz
Wednesday, March 07 \| 7:30PM - 10:00PM Poster Session 3 Room: Mesa C
Thursday, March 08 \| 7:00AM - 8:00AM Breakfast Room: Chamisa/Ortiz
Thursday, March 08 \| 8:00AM - 11:00AM RNA Localization and Transport Room: Mesa A-B Speaker 1 of 7 * Maurice S. Swanson, University of Florida, USA
Thursday, March 08 \| 8:00AM - 11:00AM RNA Localization and Transport Room: Mesa A-B Speaker 2 of 7 Robert H. Singer, Albert Einstein College of Medicine, USA Imaging the Life Cycle of a Single mRNA Molecule
Thursday, March 08 \| 8:00AM - 11:00AM RNA Localization and Transport Room: Mesa A-B Speaker 3 of 7 Anne Ephrussi, European Molecular Biology Laboratory, Germany Nuclear Events Critical for Oskar mRNA Transport in the Oocyte
Thursday, March 08 \| 8:00AM - 11:00AM RNA Localization and Transport Room: Mesa A-B Speaker 4 of 7 David S. Booth, University of California San Francisco, USA Short Talk: Reconstitution of the HIV1 Nuclear Export Particle
Thursday, March 08 \| 8:00AM - 11:00AM RNA Localization and Transport Room: Mesa A-B Speaker 5 of 7 Thomas Gonatopoulos-Pournatzis, University of Dundee, UK Short Talk: RAM: A Novel and Essential Component of the Human mRNA Cap Methyltransferase
Thursday, March 08 \| 8:00AM - 11:00AM RNA Localization and Transport Room: Mesa A-B Speaker 6 of 7 Takeshi Chujo, Hokkaido University, Japan Short Talk: Molecular Mechanism to Regulate mRNA Metabolism in Human Mitochondria
Thursday, March 08 \| 8:00AM - 11:00AM RNA Localization and Transport Room: Mesa A-B Speaker 7 of 7 Pooja M. Desai, Emory University School of Medicine, USA Short Talk: Molecular Mechanisms of Substrate Recognition by m1A1408 Aminoglycoside-Resistance rRNA Methyltranserases
Thursday, March 08 \| 9:20AM - 9:40AM Coffee Break Room: Promenade
Thursday, March 08 \| 11:00AM - 11:00AM On Own for Lunch and Recreation
Thursday, March 08 \| 4:30PM - 5:00PM Coffee Available Room: Promenade
Thursday, March 08 \| 5:00PM - 7:00PM Structural Biology of RBPs and RNPs Room: Mesa A-B Speaker 1 of 4 * Joan A. Steitz, Yale University, USA
Thursday, March 08 \| 5:00PM - 7:00PM Structural Biology of RBPs and RNPs Room: Mesa A-B Speaker 2 of 4 Kiyoshi Nagai, Medical Research Council, UK Structural Studies of the Spliceosomal snRNPs
Thursday, March 08 \| 5:00PM - 7:00PM Structural Biology of RBPs and RNPs Room: Mesa A-B Speaker 3 of 4 Reinhard Lührmann, Max Planck Institute for Biophysical Chemistry, Germany Structure and Mechanism of the Spliceosome
Thursday, March 08 \| 5:00PM - 7:00PM Structural Biology of RBPs and RNPs Room: Mesa A-B Speaker 4 of 4 Elena Conti, Max Planck Institute of Biochemistry, Germany Structural Insights into the Functions of the Exon-Junction Complex
Thursday, March 08 \| 8:00PM - 9:00PM Social Hour with Lite Bites Room: Mesa Ballroom
Thursday, March 08 \| 8:00PM - 11:00PM Entertainment Room: Mesa Ballroom
Thursday, March 08 \| 9:00PM - 11:00PM Cash Bar Room: Mesa Ballroom
Friday, March 09 \| 10:25AM - 10:25AM Departure *Session Chair.