Web Desc
Protein-RNA Interactions in Biology and Disease
Organizer(s): Thomas Tuschl, Mikiko C. Siomi and Gideon Dreyfuss
Date: March 04 - 09, 2012
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA
Supported by the Directors' Fund
Summary of Meeting:
Cellular functions depend on numerous protein-coding and noncoding RNAs and the RNA-binding proteins (RBPs) associated with them, which form ribonucleoprotein complexes (RNPs). Mutations that disrupt either the RNA or protein components of RNPs or the factors required for their assembly can be deleterious. The discovery of disease-causing mutations in RNAs or their interacting RBPs not only adds to our growing understanding of RNA biology and chemistry, but also offers new therapeutic targets and contributes to ongoing efforts in developing mRNA-targeting antisense and RNAi therapeutics. This meeting focuses on a general understanding of post-transcriptional gene regulation and how perturbation of complex networks of RNA-protein and RNA-RNP interactions triggers disease.
Scholarship Deadline: November 2 2011
Discounted Abstract Deadline: November 2 2011
Abstract Deadline: December 8 2011
Discounted Registration Deadline: January 5 2012
We gratefully acknowledge additional support for this conference from:
Integrated DNA Technologies
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
EMBO (European Molecular Biology Organization)
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS076178-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 04 | 3:00PM - 7:30PM
Registration
Room: Promenade


Sunday, March 04 | 6:15PM - 7:15PM
Refreshments
Room: Promenade


Sunday, March 04 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Mesa A-B

Speaker 1 of 2
* Gideon Dreyfuss, HHMI/University of Pennsylvania School of Medicine, USA

Sunday, March 04 | 7:15PM - 8:30PM
Welcome and Keynote Address
Room: Mesa A-B

Speaker 2 of 2
Witold Filipowicz, Friedrich Miescher Institute for Biomedical Research, Switzerland
Mechanism and Regulation of microRNA Repression in Mammalian Cells

Monday, March 05 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Monday, March 05 | 8:00AM - 11:15AM
Genetic Diseases Caused by Alterations of RBP or RNA Sequenc
e: Part 1

Room: Mesa A-B

Speaker 1 of 7
* Reinhard Lührmann, Max Planck Institute for Biophysical Chemistry, Germany

Monday, March 05 | 8:00AM - 11:15AM
Genetic Diseases Caused by Alterations of RBP or RNA Sequenc
e: Part 1

Room: Mesa A-B

Speaker 2 of 7
Tom Maniatis, New York Genome Center, USA
The Role of RNA-Binding Proteins in ALS

Monday, March 05 | 8:00AM - 11:15AM
Genetic Diseases Caused by Alterations of RBP or RNA Sequenc
e: Part 1

Room: Mesa A-B

Speaker 3 of 7
Francisco E. Baralle, International Center for Genetic Engineering, Italy
New Apects of TDP 43 Self-Regulation Mechanisms and their Connection with Neurological Disease

Monday, March 05 | 8:00AM - 11:15AM
Genetic Diseases Caused by Alterations of RBP or RNA Sequenc
e: Part 1

Room: Mesa A-B

Speaker 4 of 7
Maurice S. Swanson, University of Florida, USA
RNA Toxicity in Microsatellite Expansion Disease

Monday, March 05 | 8:00AM - 11:15AM
Genetic Diseases Caused by Alterations of RBP or RNA Sequenc
e: Part 1

Room: Mesa A-B

Speaker 5 of 7
Nancy M. Bonini, University of Pennsylvania, USA
RNA Pathways and their Impact on Brain Degeneration: Insight from Drosophila

Monday, March 05 | 8:00AM - 11:15AM
Genetic Diseases Caused by Alterations of RBP or RNA Sequenc
e: Part 1

Room: Mesa A-B

Speaker 6 of 7
Susan L. Ackerman, University of California, San Diego, USA
Short Talk: Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration

Monday, March 05 | 8:00AM - 11:15AM
Genetic Diseases Caused by Alterations of RBP or RNA Sequenc
e: Part 1

Room: Mesa A-B

Speaker 7 of 7
Cara L. Lunn, Washington University School of Medicine, USA
Short Talk: U2AF1 Mutations in Myelodysplastic Syndromes

Monday, March 05 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Monday, March 05 | 11:15AM - 1:00PM
Poster Setup
Room: Mesa C


Monday, March 05 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Monday, March 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Monday, March 05 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Monday, March 05 | 5:00PM - 7:15PM
Genetic Diseases Caused by Alterations of RBP or RNA Sequenc
e: Part 2

Room: Mesa A-B

Speaker 1 of 6
* Thomas R. Cech, HHMI/University of Colorado, USA

Monday, March 05 | 5:00PM - 7:15PM
Genetic Diseases Caused by Alterations of RBP or RNA Sequenc
e: Part 2

Room: Mesa A-B

Speaker 2 of 6
Randi J. Hagerman, University of California, Davis Health System, USA
Fragile X Syndrome and FXTAS

Monday, March 05 | 5:00PM - 7:15PM
Genetic Diseases Caused by Alterations of RBP or RNA Sequenc
e: Part 2

Room: Mesa A-B

Speaker 3 of 6
Miguel Angel Moreno-Pelayo, Hospital Ramón y Cajal, Spain
miR-96 and Hereditary Hearing Loss: First Example of Point Mutations in the Mature Sequence of a miRNA with an Ethiopathogenetic Role in a Human Mendelian Disease

Monday, March 05 | 5:00PM - 7:15PM
Genetic Diseases Caused by Alterations of RBP or RNA Sequenc
e: Part 2

Room: Mesa A-B

Speaker 4 of 6
Gideon Dreyfuss, HHMI/University of Pennsylvania School of Medicine, USA
Function and Mechanism of the SMN Complex: Insights into snRNP Biogenesis, mRNA Regulation and SMA Pathogenesis

Monday, March 05 | 5:00PM - 7:15PM
Genetic Diseases Caused by Alterations of RBP or RNA Sequenc
e: Part 2

Room: Mesa A-B

Speaker 5 of 6
Shuo-Chien Ling, National University of Singapore, Singapore
Short Talk: Progressive Lower Motor Neuron Defects in Mice Expressing Wild Type or ALS-Linked Mutants of FUS/TLS

Monday, March 05 | 5:00PM - 7:15PM
Genetic Diseases Caused by Alterations of RBP or RNA Sequenc
e: Part 2

Room: Mesa A-B

Speaker 6 of 6
J. Paul Taylor, St. Jude Children's Research Hospital, USA
Short Talk: Mutations in Prion-Like Domains Found in hnRNPA2B1 and hnRNPA1 Cause Multisystem Proteinopathy

Monday, March 05 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Chamisa/Ortiz


Monday, March 05 | 7:30PM - 10:00PM
Poster Session 1
Room: Mesa C


Tuesday, March 06 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Tuesday, March 06 | 8:00AM - 11:15AM
Defining the Elements and Interactions of Post-Transcription
al Networks

Room: Mesa A-B

Speaker 1 of 6
* James L. Manley, Columbia University, USA

Tuesday, March 06 | 8:00AM - 11:15AM
Defining the Elements and Interactions of Post-Transcription
al Networks

Room: Mesa A-B

Speaker 2 of 6
Chris B. Burge, Massachusetts Institute of Technology, USA
Regulation of Splicing and Localization of mRNAs by Muscleblind Proteins

Tuesday, March 06 | 8:00AM - 11:15AM
Defining the Elements and Interactions of Post-Transcription
al Networks

Room: Mesa A-B

Speaker 3 of 6
Thomas Tuschl, HHMI/Rockefeller University, USA
Defining Post-Transcriptional Regulatory Networks

Tuesday, March 06 | 8:00AM - 11:15AM
Defining the Elements and Interactions of Post-Transcription
al Networks

Room: Mesa A-B

Speaker 4 of 6
Falk Butter, Max Planck Institute for Biochemistry, Germany
Mass Spectrometry for Complete Proteome Identification and Post-Transcriptional Regulation

Tuesday, March 06 | 8:00AM - 11:15AM
Defining the Elements and Interactions of Post-Transcription
al Networks

Room: Mesa A-B

Speaker 5 of 6
Stephanie C. Huelga, University of California, San Diego, USA
Short Talk: Integrative Genome-Wide Analysis Reveals Cooperative Regulation of Alternative Splicing by hnRNP Proteins

Tuesday, March 06 | 8:00AM - 11:15AM
Defining the Elements and Interactions of Post-Transcription
al Networks

Room: Mesa A-B

Speaker 6 of 6
Andreas R. Gruber, University of Basel, Switzerland
Short Talk: Global Maps of Pre-mRNA 3’ End Processing Factor Binding and Polyadenylation Sites

Tuesday, March 06 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Tuesday, March 06 | 11:15AM - 1:00PM
Poster Setup
Room: Mesa C


Tuesday, March 06 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Tuesday, March 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Tuesday, March 06 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Tuesday, March 06 | 5:00PM - 7:00PM
RNAi Mechanism and miRNAs
Room: Mesa A-B

Speaker 1 of 5
* Elena Conti, Max Planck Institute of Biochemistry, Germany

Tuesday, March 06 | 5:00PM - 7:00PM
RNAi Mechanism and miRNAs
Room: Mesa A-B

Speaker 2 of 5
Mikiko C. Siomi, University of Tokyo, Japan
Biogenesis of PIWI-Interacting Small RNAs in Drosophila

Tuesday, March 06 | 5:00PM - 7:00PM
RNAi Mechanism and miRNAs
Room: Mesa A-B

Speaker 3 of 5
V. Narry Kim, Institute for Basic Science, South Korea
Regulation of MicroRNA via Monouridylation of Pre-miRNA

Tuesday, March 06 | 5:00PM - 7:00PM
RNAi Mechanism and miRNAs
Room: Mesa A-B

Speaker 4 of 5
Bryan R. Cullen, Duke University Medical Center, USA
Viruses and microRNAs

Tuesday, March 06 | 5:00PM - 7:00PM
RNAi Mechanism and miRNAs
Room: Mesa A-B

Speaker 5 of 5
Doron Betel, Weill Cornell Medical College, USA
Short Talk: Genome Wide Identification of miRNA Target Sites by CLIP-Based Methods

Tuesday, March 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa/Ortiz


Tuesday, March 06 | 7:30PM - 10:00PM
Poster Session 2
Room: Mesa C


Wednesday, March 07 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Wednesday, March 07 | 8:00AM - 11:15AM
RNPs and RNA Processing: Part 1
Room: Mesa A-B

Speaker 1 of 7
* V. Narry Kim, Institute for Basic Science, South Korea

Wednesday, March 07 | 8:00AM - 11:15AM
RNPs and RNA Processing: Part 1
Room: Mesa A-B

Speaker 2 of 7
Alberto R. Kornblihtt, Universidad de Buenos Aires, Argentina
Chromatin, Epigenetics and Alternative Splicing

Wednesday, March 07 | 8:00AM - 11:15AM
RNPs and RNA Processing: Part 1
Room: Mesa A-B

Speaker 3 of 7
James L. Manley, Columbia University, USA
Processing of mRNA Precursors and Links to Human Disease

Wednesday, March 07 | 8:00AM - 11:15AM
RNPs and RNA Processing: Part 1
Room: Mesa A-B

Speaker 4 of 7
Joan A. Steitz, Yale University, USA
Probing Viral Noncoding RNAs to Illuminate Novel microRNA Processing Pathways, Mechanisms of RNA Stability and microRNA Function

Wednesday, March 07 | 8:00AM - 11:15AM
RNPs and RNA Processing: Part 1
Room: Mesa A-B

Speaker 5 of 7
Ashley T. Neff, Colorado State University, USA
Short Talk: Global Analysis Reveals Pathways of Unique Regulation of mRNA Decay in Human Induced Pluripotent Stem Cells

Wednesday, March 07 | 8:00AM - 11:15AM
RNPs and RNA Processing: Part 1
Room: Mesa A-B

Speaker 6 of 7
Thomas R. Cech, HHMI/University of Colorado, USA
Two Noncoding RNPs, Telomerase and FUS/TLS

Wednesday, March 07 | 8:00AM - 11:15AM
RNPs and RNA Processing: Part 1
Room: Mesa A-B

Speaker 7 of 7
Mauro Costa-Mattioli, Baylor College of Medicine, USA
Short Talk: Suppression of PKR Promotes Network Hypersynchrony and Enhanced Cognition by Interferon-gamma Mediated Disinhibition

Wednesday, March 07 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Wednesday, March 07 | 11:15AM - 1:00PM
Poster Setup
Room: Mesa C


Wednesday, March 07 | 11:15AM - 11:15AM
On Own for Lunch and Recreation


Wednesday, March 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Wednesday, March 07 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Wednesday, March 07 | 5:00PM - 7:00PM
RNPs and RNA Processing: Part 2
Room: Mesa A-B

Speaker 1 of 5
* Nancy M. Bonini, University of Pennsylvania, USA

Wednesday, March 07 | 5:00PM - 7:00PM
RNPs and RNA Processing: Part 2
Room: Mesa A-B

Speaker 2 of 5
Nahum Sonenberg, McGill University, Canada
Cap-Binding Proteins and their Role in Translation Initiation

Wednesday, March 07 | 5:00PM - 7:00PM
RNPs and RNA Processing: Part 2
Room: Mesa A-B

Speaker 3 of 5
Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany
GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets

Wednesday, March 07 | 5:00PM - 7:00PM
RNPs and RNA Processing: Part 2
Room: Mesa A-B

Speaker 4 of 5
Benjamin J. Blencowe, University of Toronto, Canada
Systematic Analysis of the Function and Regulation of Alternative Exon Networks

Wednesday, March 07 | 5:00PM - 7:00PM
RNPs and RNA Processing: Part 2
Room: Mesa A-B

Speaker 5 of 5
Ram Kannan, Stowers Institute For Medical Research, USA
Short Talk: Telomerase RNA Biogenesis: Splicing versus Spliceosomal Cleavage

Wednesday, March 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa/Ortiz


Wednesday, March 07 | 7:30PM - 10:00PM
Poster Session 3
Room: Mesa C


Thursday, March 08 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Thursday, March 08 | 8:00AM - 11:00AM
RNA Localization and Transport
Room: Mesa A-B

Speaker 1 of 7
* Maurice S. Swanson, University of Florida, USA

Thursday, March 08 | 8:00AM - 11:00AM
RNA Localization and Transport
Room: Mesa A-B

Speaker 2 of 7
Robert H. Singer, Albert Einstein College of Medicine, USA
Imaging the Life Cycle of a Single mRNA Molecule

Thursday, March 08 | 8:00AM - 11:00AM
RNA Localization and Transport
Room: Mesa A-B

Speaker 3 of 7
Anne Ephrussi, European Molecular Biology Laboratory, Germany
Nuclear Events Critical for Oskar mRNA Transport in the Oocyte

Thursday, March 08 | 8:00AM - 11:00AM
RNA Localization and Transport
Room: Mesa A-B

Speaker 4 of 7
David S. Booth, University of California San Francisco, USA
Short Talk: Reconstitution of the HIV1 Nuclear Export Particle

Thursday, March 08 | 8:00AM - 11:00AM
RNA Localization and Transport
Room: Mesa A-B

Speaker 5 of 7
Thomas Gonatopoulos-Pournatzis, University of Dundee, UK
Short Talk: RAM: A Novel and Essential Component of the Human mRNA Cap Methyltransferase

Thursday, March 08 | 8:00AM - 11:00AM
RNA Localization and Transport
Room: Mesa A-B

Speaker 6 of 7
Takeshi Chujo, Hokkaido University, Japan
Short Talk: Molecular Mechanism to Regulate mRNA Metabolism in Human Mitochondria

Thursday, March 08 | 8:00AM - 11:00AM
RNA Localization and Transport
Room: Mesa A-B

Speaker 7 of 7
Pooja M. Desai, Emory University School of Medicine, USA
Short Talk: Molecular Mechanisms of Substrate Recognition by m1A1408 Aminoglycoside-Resistance rRNA Methyltranserases

Thursday, March 08 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Thursday, March 08 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Thursday, March 08 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Thursday, March 08 | 5:00PM - 7:00PM
Structural Biology of RBPs and RNPs
Room: Mesa A-B

Speaker 1 of 4
* Joan A. Steitz, Yale University, USA

Thursday, March 08 | 5:00PM - 7:00PM
Structural Biology of RBPs and RNPs
Room: Mesa A-B

Speaker 2 of 4
Kiyoshi Nagai, Medical Research Council, UK
Structural Studies of the Spliceosomal snRNPs

Thursday, March 08 | 5:00PM - 7:00PM
Structural Biology of RBPs and RNPs
Room: Mesa A-B

Speaker 3 of 4
Reinhard Lührmann, Max Planck Institute for Biophysical Chemistry, Germany
Structure and Mechanism of the Spliceosome

Thursday, March 08 | 5:00PM - 7:00PM
Structural Biology of RBPs and RNPs
Room: Mesa A-B

Speaker 4 of 4
Elena Conti, Max Planck Institute of Biochemistry, Germany
Structural Insights into the Functions of the Exon-Junction Complex

Thursday, March 08 | 8:00PM - 9:00PM
Social Hour with Lite Bites
Room: Mesa Ballroom


Thursday, March 08 | 8:00PM - 11:00PM
Entertainment
Room: Mesa Ballroom


Thursday, March 08 | 9:00PM - 11:00PM
Cash Bar
Room: Mesa Ballroom


Friday, March 09 | 10:25AM - 10:25AM
Departure


*Session Chair.